Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 19/04/2021
• Auteurs : Marie Armani-TourretZhicheng ZhouRomain GasserIsabelle StaropoliVincent Cantaloube-FerrieuYann BenureauJavier Garcia-PerezMayte Pérez-OlmedaValérie LorinBénédicte Puissant-LubranoLambert AssoumouConstance DelaugerreJean-Daniel LelièvreYves LévyHugo MouquetGuillaume Martin-BlondelJose AlcamiFernando Arenzana-SeisdedosJacques IzopetPhilippe ColinBernard Lagane
• Organismes : Institut Toulousain des Maladies Infectieuses et Inflammatoires Pathogénie Virale - Viral Pathogenesis Institut Toulousain des Maladies Infectieuses et Inflammatoires Pathogénie Virale - Viral Pathogenesis Institut Toulousain des Maladies Infectieuses et Inflammatoires Pathogénie Virale - Viral Pathogenesis Instituto de Salud Carlos III [Madrid] Instituto de Salud Carlos III [Madrid] Immunologie humorale - Humoral Immunology Institut Toulousain des Maladies Infectieuses et Inflammatoires Institut Pierre Louis d'Epidémiologie et de Santé Publique Génomes, biologie cellulaire et thérapeutiques CHU Henri Mondor [Créteil] CHU Henri Mondor [Créteil] Immunologie humorale - Humoral Immunology Institut Toulousain des Maladies Infectieuses et Inflammatoires Service Maladies infectieuses et tropicales [CHU Toulouse] Instituto de Salud Carlos III [Madrid] Pathogénie Virale - Viral Pathogenesis Institut Toulousain des Maladies Infectieuses et Inflammatoires Laboratoire Virologie [CHU Toulouse] Institut Toulousain des Maladies Infectieuses et Inflammatoires Institut Toulousain des Maladies Infectieuses et Inflammatoires
• Publié dans PLoS Pathogens le 27/10/2020

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Résumé : HIV-1 infects CD4 T lymphocytes (CD4TL) through binding the chemokine receptors CCR5 or CXCR4. CXCR4-using viruses are considered more pathogenic, linked to accelerated depletion of CD4TL and progression to AIDS. However, counterexamples to this paradigm are common, suggesting heterogeneity in the virulence of CXCR4-using viruses. Here, we investigated the role of the CXCR4 chemokine CXCL12 as a driving force behind virus virulence. In vitro, CXCL12 prevents HIV-1 from binding CXCR4 and entering CD4TL, but its role in HIV-1 transmission and propagation remains speculative. Through analysis of thirty envelope glycoproteins (Envs) from patients at different stages of infection, mostly treatment-naïve, we first interrogated whether sensitivity of viruses to inhibition by CXCL12 varies over time in infection. Results show that Envs resistant (RES) to CXCL12 are frequent in patients experiencing low CD4TL levels, most often late in infection, only rarely at the time of primary infection. Sensitivity assays to soluble CD4 or broadly neutralizing antibodies further showed that RES Envs adopt a more closed conformation with distinct antigenicity, compared to CXCL12-sensitive (SENS) Envs. At the level of the host cell, our results suggest that resistance is not due to improved fusion or binding to CD4, but owes to viruses using particular CXCR4 molecules weakly accessible to CXCL12. We finally asked whether the low CD4TL levels in patients are related to increased pathogenicity of RES viruses. Resistance actually provides viruses with an enhanced capacity to enter naive CD4TL when surrounded by CXCL12, which mirrors their situation in lymphoid organs, and to deplete bystander activated effector memory cells. Therefore, RES viruses seem more likely to deregulate CD4TL homeostasis. This work improves our understanding of the pathophysiology and the transmission of HIV-1 and suggests that RES viruses' receptors could represent new therapeutic targets to help prevent CD4TL depletion in HIV+ patients on cART.

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Fichiers liés : journal.ppat.1009526.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/04/2021
• Auteurs : Christophe LucchesiDilek CakirogluJean-Philippe PerezThierry TaliercioEric TourniéPierre-Olivier ChapuisRodolphe Vaillon
• Organismes : Centre d'Energétique et de Thermique de Lyon Composants à Nanostructure pour le moyen infrarouge Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Institut d’Electronique et des Systèmes Centre d'Energétique et de Thermique de Lyon Micro électronique, Composants, Systèmes, Efficacité Energétique Institut d’Electronique et des Systèmes

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• Type de publi. : Article dans une revue
• Date de publi. : 16/04/2021
• Auteurs : Jeremy CheradameJulien PiscioneChristopher CarlingJean-Pierre GuinoiseauBernard DufourHelene Jacqmin-GaddaPhilippe Decq
• Organismes : Bordeaux population health
• Publié dans The American Journal of Sports Medicine le 29/10/2020

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Résumé : BACKGROUND: Concussions are a source of major concern in rugby, and a limited number of studies have attempted to identify risk factors for these injuries. PURPOSE: To investigate the incidence of match concussion and associated risk factors, including individual workload, anthropometric variables, playing position, and season phase, in elite rugby union players. STUDY DESIGN: Case-control study; Level of evidence 3. METHODS: All concussions and explanatory variables were collected for every match over 5 consecutive seasons (2014-2018) in 1334 professional players participating in the French Top 14 championship. Concussion risk was estimated using mixed effects Poisson regression. RESULTS: Mean match concussion incidence equated to 10.4 (95% CI, 9.3-11.5) concussions for 1000 hours of game exposure. A peak was reached in the 2016-2017 season (13.7; 95% CI, 11.0-16.5). A greater risk was observed in the playoffs as compared with the first phase of the season (incidence rate ratio, 3.96; 95% CI, 2.10-7.35). In comparison with other positions, half-backs incurred the highest rate of concussion events (incidence, 16.1; 95% CI, 11.8-20.3). Irrespective of playing position, those with greater height and lower body mass reported a higher risk of concussions (P = .02), especially during tackling actions for lighter players (P = .01) and during other match events for taller players (P = .03). When adjusted for season phase, players who had accumulated a higher amount of playing time since the beginning of the season demonstrated a lower risk of concussion (P = .005). CONCLUSION: Inter- and intraseasonal variations in concussion rates were observed. Within positional groups, lighter and taller players were more at risk, with the highest incidence generally observed in half-backs. Workload was measured by the number of matches played before a concussion event, and it appeared to have a protective rather than deleterious effect on concussion risk.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2021
• Auteurs : Philippe MassicotteRainer AmonDavid AntoinePhilippe ArchambaultSergio BalzanoSimon BélangerRonald BennerDominique BoeufAnnick BricaudFlavienne BruyantGwénaëlle ChaillouMalik ChamiBruno CharrièreJianfang ChenHervé ClaustrePierre Vincent CoupelNicole DelsautDavid DoxaranJens EhnCédric FichotMarie-Hélène ForgetPingqing FuJonathan GagnonNicole GarciaBeat GasserJean-François GhiglioneGabriel GorskyMichel GosselinPriscillia GourvilYves GrattonPascal GuillotHermann J. HeipieperSerge HeussnerStanford B. HookerYannick HuotChristian JeanthonWade JeffreyFabien JouxKimitaka KawamuraBruno LansardEdouard LeymarieHeike LinkConnie LovejoyClaudie MarecDominique MarieJohannie MartinJacobo MartinGuillaume MasséAtsushi MatsuokaVanessa MckagueAlexandre MignotWilliam L. MillerJuan-Carlos MiquelAlfonso MucciKaori OnoEva Ortega-RetuertaChristos PanagiotopoulosTimothy PapakyriakouMarc PicheralDieter PiepenburgLouis PrieurPatrick RaimbaultJ. RasRick A. ReynoldsAndré RochonJean-Francois RontaniCatherine SchmechtigSabine SchmidtRichard SempereYuan ShenGuisheng SongDariusz StramskiEri TachibanaAlexandre ThirouardImma TolosaJean-Éric TremblayMickaël VaïtilingomDaniel VaulotFrederic VaultierJohn K. VolkmanJorien E. VonkHuixiang XieGuangming ZhengMarcel Babin
• Organismes : Takuvik Joint International Laboratory ULAVAL-CNRS Department of Marine and Coastal Environmental Science [Galveston] Department of Oceanography [College Station] School of Earth and Planetary Sciences [Perth] Laboratoire d'océanographie de Villefranche Takuvik Joint International Laboratory ULAVAL-CNRS Station biologique de Roscoff = Roscoff Marine Station Royal Netherlands Institute for Sea Research Stazione Zoologica Anton Dohrn Departement de Biologie, Chimie et Géographie School of the Earth, Ocean and Environment [Columbia] Department of Biological Sciences [Columbia] Station biologique de Roscoff = Roscoff Marine Station Laboratoire d'océanographie de Villefranche Takuvik Joint International Laboratory ULAVAL-CNRS Institut des Sciences de la MER de Rimouski TROPO - LATMOS Centre de Formation et de Recherche sur les Environnements Méditérranéens State key Laboratory of Environmental Geochemistry [Guiyang] Laboratoire d'océanographie de Villefranche Takuvik Joint International Laboratory ULAVAL-CNRS Centre de Formation et de Recherche sur les Environnements Méditérranéens Laboratoire d'océanographie de Villefranche Centre for Earth Observation Science [Winnipeg] Department of Earth and Environment [Boston] Takuvik Joint International Laboratory ULAVAL-CNRS Institute of Surface-Earth System Science of Tianjin University Takuvik Joint International Laboratory ULAVAL-CNRS Institut méditerranéen d'océanologie International Atomic Energy Agency - Environment Laboratories Monaco Laboratoire d'Océanographie Microbienne Laboratoire d'océanographie de Villefranche Institut des Sciences de la MER de Rimouski Station biologique de Roscoff = Roscoff Marine Station Fédération de recherche de Roscoff Centre Eau Terre Environnement [Québec] Institut des Sciences de la MER de Rimouski Department of Environmental Biotechnology [UFZ Leipzig] Centre de Formation et de Recherche sur les Environnements Méditérranéens GSFC Ocean Ecology Laborator Département de géomatique appliquée [Sherbrooke] Station biologique de Roscoff = Roscoff Marine Station Center for Environmental Diagnostics and Bioremediation [Pensacola] Laboratoire d'Océanographie Microbienne Chubu Institute for Advanced Studies Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Océan et Interfaces Laboratoire d'océanographie de Villefranche Department of Maritime Systems [Rostock] Takuvik Joint International Laboratory ULAVAL-CNRS Takuvik Joint International Laboratory ULAVAL-CNRS Institut Universitaire Européen de la Mer Station biologique de Roscoff = Roscoff Marine Station Takuvik Joint International Laboratory ULAVAL-CNRS Centro Austral de Investigaciones Científicas [Ushuaia] Instituto de Ciencias Polares, Ambiente y Recursos Naturales Station de Biologie Marine de Concarneau Variabilité de l'Océan et de la Glace de mer Takuvik Joint International Laboratory ULAVAL-CNRS Center for Marine and Environmental Studies Laboratoire d'océanographie de Villefranche Mercator Océan Department of Marine Sciences [Athens] International Atomic Energy Agency - Environment Laboratories Monaco Centre de recherche sur la dynamique du système Terre Department of Earth and Planetary Sciences [Montréal] Institute of Low Temperature Science [Sapporo] Laboratoire d'Océanographie Microbienne Institut méditerranéen d'océanologie Centre for Earth Observation Science [Winnipeg] Laboratoire d'océanographie de Villefranche Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung = Alfred Wegener Institute for Polar and Marine Research = Institut Alfred-Wegener pour la recherche polaire et marine Helmholtz Institute for Functional Marine Biodiversity at the University of Oldenburg Laboratoire d'océanographie de Villefranche Institut méditerranéen d'océanologie Laboratoire d'océanographie de Villefranche Marine Physical Laboratory Institut des Sciences de la MER de Rimouski Institut méditerranéen d'océanologie Observatoire des sciences de l'univers Ecce Terra [Paris] Environnements et Paléoenvironnements OCéaniques Institut méditerranéen d'océanologie School of the Earth, Ocean and Environment [Columbia] State Key Laboratory of Marine Environmental Science Institut des Sciences de la MER de Rimouski School of Marine Science and Technology [Tianjin] Marine Physical Laboratory Institute of Low Temperature Science [Sapporo] Laboratoire d'océanographie de Villefranche International Atomic Energy Agency - Environment Laboratories Monaco Takuvik Joint International Laboratory ULAVAL-CNRS Laboratoire de Recherche en Géosciences et Energies [UR2_1] Station biologique de Roscoff = Roscoff Marine Station Asian School of the Environment Institut méditerranéen d'océanologie CSIRO Marine and Atmospheric Research CSIRO Wealth from Oceans National Research Flagship Department of Earth Sciences [Amsterdam] Institut des Sciences de la MER de Rimouski Marine Physical Laboratory NOAA Center for Satellite Applications and Research Earth Science System Interdisciplinary Center [College Park] Stazione Zoologica Anton Dohrn Takuvik Joint International Laboratory ULAVAL-CNRS
• Publié dans Earth System Science Data le 23/10/2020

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Résumé : The MALINA oceanographic campaign was conducted during summer 2009 to investigate the carbon stocks and the processes controlling the carbon fluxes in the Mackenzie River estuary and the Beaufort Sea. Dur- ing the campaign, an extensive suite of physical, chemical and biological variables was measured across seven shelf–basin transects (south-north) to capture the meridional gradient between the estuary and the open ocean.Key variables such as temperature, absolute salinity, radiance, irradiance, nutrient concentrations, chlorophyll-a concentration, bacteria, phytoplankton and zooplankton abundance and taxonomy, and carbon stocks and fluxes were routinely measured onboard the Canadian research icebreaker CCGS Amundsen and from a barge in shallow coastal areas or for sampling within broken ice fields. Here, we present the results of a joint effort to tidy and standardize the collected data sets that will facilitate their reuse in further studies of the changing Arctic Ocean.

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Fichiers liés : essd-13-1561-2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2021
• Auteurs : Philippe CorciaWilliam CamuCeline BrulardSylviane MarouillatPhilippe CouratierJean-Philippe CamdessanchéPascal CintasAnnie VerschuerenMarie-Helene SorianiClaude DesnuelleMarie-Céline FleuryNathalie GuyJulien CassereauFausto ViaderSophie Pittion-VouyovitchVeronique DanelIvan KolevGwendal Le MassonStephane BeltranFrancois SalachasEmilien BernardPierre-François PradatHélène BlascoDébora LanznasterRudolph HergesheimerFrederic LaumonnierChristian R. AndresVincent MeiningerPatrick Vourc’h
• Organismes : Service de Neurologie, CHU Tours Imaging, Brain & Neuropsychiatry Université de Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Département Neurologie [CHU Toulouse] centre de références des maladies neuromusculaires Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Nice Service de Neurologie [CHU Strasbourg] Centre de compétence de la Sclérose Latérale Amyotrophique [CHU Clermont-Ferrand] Unité de Neurologie, Département de Neurologie, CHU d’Angers, Angers, France Neuropsychologie et imagerie de la mémoire humaine Centre Hospitalier Universitaire de Nancy Département de Pharmacologie Médicale [Lille] Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] Service de neurologie [Bordeaux] Université de Tours CHU Pitié-Salpêtrière [AP-HP] Hopital universitaire de Lyon CHU Pitié-Salpêtrière [AP-HP] Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Imaging, Brain & Neuropsychiatry Service de Médecine Nucléaire [Tours] Service de Médecine Nucléaire [Tours] Université de Tours
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

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Résumé : Objectives To determine whether the familial clustering of amyotrophic lateral sclerosis (ALS) cases and the phenotype of the disease may help identify the pathogenic genes involved. Methods We conducted a targeted next-generation sequencing analysis on 235 French familial ALS (FALS), unrelated probands to identify mutations in 30 genes linked to the disease. The genealogy, that is, number of cases and generations with ALS, gender, age, site of onset and the duration of the disease were analysed. Results Regarding the number of generations, 49 pedigrees had only one affected generation, 152 had two affected generations and 34 had at least three affected generations. Among the 149 pedigrees (63.4%) for which a deleterious variant was found, an abnormal G4C2 expansion in C9orf72 was found in 98 cases as well as SOD1 , TARBP or FUS mutations in 30, 9 and 7 cases, respectively. Considering pedigrees from the number of generations, abnormal G4C2 expansion in C9orf72 was more frequent in pedigrees with pairs of affected ALS cases, which represented 65.2% of our cohort. SOD1 mutation involved all types of pedigrees. No TARDBP nor FUS mutation was present in monogenerational pedigrees. TARDBP mutation predominated in bigenerational pedigrees with at least three cases and FUS mutation in multigenerational pedigrees with more than seven cases, on average, and with an age of onset younger than 45 years. Conclusion Our results suggest that familial clustering, phenotypes and genotypes are interconnected in FALS, and thus it might be possible to target the genetic screening from the familial architecture and the phenotype of ALS cases.

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• Type de publi. : Article dans une revue
• Date de publi. : 14/04/2021
• Auteurs : Hanspeter NaegeliJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiFernando ÁlvarezMichele ArdizzoneGiacomo de SanctisYann DevosAntonio Fernandez DumontSilvia FedericiAndrea GennaroJose Ángel Gómez RuizAnna LanzoniFranco Maria NeriNikoletta PapadopoulouKonstantinos ParaskevopoulosTommaso Raffaello
• Organismes : Institute of Pharmacology and Toxicology [Zurich] Earlham Institute [Norwich] Department of Dermatology Division of Immunology, Allergy and Infectious Diseases Medical University of Vienna = Medizinische Universität Wien University of Leeds Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Estonian University of Life Sciences Centre for Water Research Instituto de Fisica "Gleb Wataghin" GMO Unit, European Food Safety Authority European Food Safety Authority
• Publié dans EFSA Journal le 01/11/2020

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Résumé : The European Commission mandated EFSA to complement its original scientific opinion on soybean MON 87769 3 MON 89788 (EFSA-GMO-NL-2010-85) considering additional information on the human nutritional assessment of refined bleached deodorised oil produced from the two-event stack soybean (RBD GM-oil). The assessment was mainly based on a replacement scenario with a list of target foods where RBD GM-oil is intended to be added. Intake estimations for several fatty acids present in the RBD GM-oil, in particular c-linolenic acid (GLA), stearidonic acid (SDA) and linoleic acid (LA) were based on the consumption of the corresponding foods that are likely to be displaced. The assessment of LA considered the established adequate intake of 4% of total energy intake (E%) and that LA deficiency has not been observed with intakes > 1 E%. The assessment of GLA and SDA was conducted using maximum doses without adverse effects from intervention human studies as reference (4.2 grams/day for SDA and 2.8 grams/day for GLA) since no tolerable upper intake levels are set for these fatty acids. The decrease observed in the levels of LA in RBD GM-oil as compared to oil from conventional soybean does not represent a nutritional concern as intakes were in all cases above 1 E%. For GLA, all intake estimations were below the reference dose indicating no safety concern. SDA intake estimations do not pose any safety concerns based on the overly conservative nature of the estimates, the absence of toxicological hazards and the rapid metabolism of SDA in humans. The GMO Panel concluded that the consumption of soybean MON 87769 3 MON 89788 and their derived products, in particular its RBD oil, does not represent a nutritional concern in humans. A post-market monitoring plan is recommended to confirm the predicted consumption and the application of conditions of uses considered during the pre-market risk assessment.

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Fichiers liés : j.efsa.2021.6589SOYBEAN+85.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/04/2021
• Auteurs : Antoine MoussonMarlène LegrandTania SteffanRomain VauchellesPhilippe CarlJean-Pierre GiesMaxime LehmannGuy ZuberJan de MeyDenis DujardinE. SickPhilippe Rondé
• Organismes : Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Biotechnologie et signalisation cellulaire Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies Laboratoire de Biophotonique et Pharmacologie - UMR 7213 Laboratoire de Bioimagerie et Pathologies
• Publié dans Cancers le 21/10/2020

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Résumé : The nonreceptor tyrosine kinase FAK is a promising target for solid tumor treatment because it promotes invasion, tumor progression, and drug resistance when overexpressed. In-vestigating the role of FAK in human melanoma cells, we found that both in situ and metastatic melanoma cells strongly express FAK, where it controls tumor cells’ invasiveness by regulating focal adhesion-mediated cell motility. Inhibiting FAK in human metastatic melanoma cells with either siRNA or a small inhibitor targeting the kinase domain impaired migration but led to increased invadopodia formation and extracellular matrix degradation. Using FAK mutated at Y397, we found that this unexpected increase in invadopodia activity is due to the lack of phosphorylation at this residue. To preserve FAK–Src interaction while inhibiting pro-migratory functions of FAK, we found that altering FAK–paxillin interaction, with either FAK mutation in the focal adhesion targeting (FAT) domain or a competitive inhibitor peptide mimicking paxillin LD domains drastically reduces cell migration and matrix degradation by preserving FAK activity in the cytoplasm. In conclusion, our data show that targeting FAK–paxillin interactions could be a potential therapeutic strategy to prevent metastasis formation, and molecules targeting this interface could be alternative to inhibitors of FAK kinase activity which display unexpected effects.

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Fichiers liés : islandora_121050.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/04/2021
• Auteurs : Antoine MoussonMarlène LegrandTania SteffanRomain VauchellesPhilippe CarlJean-Pierre GiesMaxime LehmannGuy ZuberJan de MeyDenis DujardinE. SickPhilippe Rondé
• Organismes : Centre National de la Recherche Scientifique
• Publié dans Cancers le 21/10/2020

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Résumé : The nonreceptor tyrosine kinase FAK is a promising target for solid tumor treatment because it promotes invasion, tumor progression, and drug resistance when overexpressed. Investigating the role of FAK in human melanoma cells, we found that both in situ and metastatic melanoma cells strongly express FAK, where it controls tumor cells’ invasiveness by regulating focal adhesion-mediated cell motility. Inhibiting FAK in human metastatic melanoma cells with either siRNA or a small inhibitor targeting the kinase domain impaired migration but led to increased invadopodia formation and extracellular matrix degradation. Using FAK mutated at Y397, we found that this unexpected increase in invadopodia activity is due to the lack of phosphorylation at this residue. To preserve FAK–Src interaction while inhibiting pro-migratory functions of FAK, we found that altering FAK–paxillin interaction, with either FAK mutation in the focal adhesion targeting (FAT) domain or a competitive inhibitor peptide mimicking paxillin LD domains drastically reduces cell migration and matrix degradation by preserving FAK activity in the cytoplasm. In conclusion, our data show that targeting FAK–paxillin interactions could be a potential therapeutic strategy to prevent metastasis formation, and molecules targeting this interface could be alternative to inhibitors of FAK kinase activity which display unexpected effects.

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• Type de publi. : Article dans une revue
• Date de publi. : 09/04/2021
• Auteurs : Coralie RaadAbdelkader BehdennaChristine FuhrmannCécile ConterDaniela CuzzubboJean-Philippe RasigadeYves BertrandCarine Domenech
• Organismes : Institute of Paediatric Haematology and Oncology, Hospices Civils de Lyon, Lyon Adaptation aux milieux extrêmes Centre Léon Bérard [Lyon] UNICANCER Hospices Civils de Lyon Hospices Civils de Lyon Center for Interdisciplinary Research and Innovation Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hospices Civils de Lyon Hospices Civils de Lyon Centre de Recherche en Cancérologie de Lyon
• Publié dans European Journal of Pediatrics le 22/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 08/04/2021
• Auteurs : Mustapha MeftahThomas BoutéraonChristophe DufourAlain HauchecornePhilippe KeckhutAdrien FinanceSlimane BekkiSadok AbbakiEmmanuel BertranLuc DaméJean-Luc EnglerPatrick H. M. GalopeauPierre GilbertLaurent LapauwAlain SarkissianAndré-Jean VieauPatrick LacroixNicolas CaignardXavier ArrateigOdile Hembise Fanton d’AndonAntoine ManginJean-Paul CartaFabrice BoustMichel MahéChristophe Mercier
• Organismes : STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales Analytic and Computational Research, Inc. - Earth Sciences STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales HELIOS - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales HELIOS - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales HELIOS - LATMOS Analytic and Computational Research, Inc. - Earth Sciences Analytic and Computational Research, Inc. - Earth Sciences Carta-Rouxel DEMR, ONERA, Université Paris Saclay [Palaiseau] Radio-club de Saint-Quentin-en-Yvelines F6KRK AMSAT-Francophone
• Publié dans Remote Sensing le 28/10/2020

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Résumé : UltraViolet & infrared Sensors at high Quantum efficiency onboard a small SATellite (UVSQ- SAT) is a small satellite at the CubeSat standard, whose development began as one of the missions in the International Satellite Program in Research and Education (INSPIRE) consortium in 2017. UVSQ- SAT is an educational, technological and scientific pathfinder CubeSat mission dedicated to the observation of the Earth and the Sun. It was imagined, designed, produced and tested by LATMOS in collaboration with its academic and industrial partners, and the French-speaking radioamateur community. About the size of a Rubik’s Cube and weighing about 2 kg, this satellite was put in orbit in January 2021 by the SpaceX Falcon 9 launch vehicle. After briefly introducing the UVSQ-SAT mission, this paper will present the importance of measuring the Earth’s radiation budget and its energy imbalance and the scientific objectives related to its various components. Finally, the first in-orbit observations will be shown (maps of the solar radiation reflected by the Earth and of the outgoing longwave radiation at the top of the atmosphere during February 2021). UVSQ-SAT is one of the few CubeSats worldwide with a scientific goal related to climate studies. It represents a research in remote sensing technologies for Climate observation and monitoring.

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Fichiers liés : remotesensing-13-01449.pdf

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