Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/03/2021
• Auteurs : Cyril BourouhFrédérik OgerXavier GromadaMaeva MorenoCharlène CarneyEmilie CourtyNabil RabhiEmmanuelle DurandSouhila AmanzougareneLionel BerberianMehdi DerhourhiLaure RollandSarah Anissa HannouPierre-Damien DenechaudZohra BenfoddaPatrick MeffreLluis FajasJulie Kerr-ConteFrançois PattouPhillippe FroguelAmelie BonnefondJean-Sébastien Annicotte
• Organismes : Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Center for Integrative Genomics - Institute of Bioinformatics, Génopode Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Center for Integrative Genomics - Institute of Bioinformatics, Génopode Recherche translationnelle sur le diabète - U 1190 Recherche translationnelle sur le diabète - U 1190 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283

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Résumé : Introduction (100 mots max) : 87 mots Le diabète de type 2 se caractérise par une perte de fonction des cellules  pancréatiques reliée à une perte d'identité. Alors que les conséquences physiopathologiques de ces altérations sont bien caractérisées, les mécanismes moléculaires en sous-tendant l'émergence restent imparfaitement caractérisées. Sur la base de nos travaux décrivant la fonction du facteur de transcription E2f1 dans contrôle de la prolifération et de la fonction de la cellule  pancréatique, l'objectif de cette étude est de définir son rôle dans le maintien de l’identité de la cellule . Méthodes (60 mots max) : 60 mots Le phénotypage métabolique et l’analyse morphométrique des ilots de Langerhans ont été réalisés à partir de souris C57bl6/J déficientes pour E2f1 spécifiquement dans la cellule  (E2f1-/-). Le transcriptome des ilots de Langerhans isolés de ces souris a été caractérisé par RNA-seq. Les données de génomique fonctionnelle ont été générées par ChIP-seq ou recueillies dans les bases de données publiques. Résultats (120 mots max) : 118 mots Les souris E2f1-/- présentent une intolérance au glucose, une diminution de la sécrétion d’insuline et une augmentation du nombre de cellules glucagon-positives. De manière intéressante, l'analyse transcriptomique des ilots isolés de ces souris révèle une altération de l'identité de la cellule  caractérisée par une diminution de l'expression de gènes spécifiques des cellules  et la mise en place d'un programme transcriptionnel alternatif. Afin d'en préciser la nature, nos analyses de génomique fonctionnelle ont montré que E2f1 joue un rôle dans la répression transcriptionnelle par un mécanisme dépendant des enzymes histone HDAC. D'un point de vue mécanistique, une analyse de protéomique associée a permis de mettre en évidence une interaction entre E2f1 et HDAC1/HDAC6 dans la cellule . Discussion - Conclusion : L’ensemble de ces résultats montrent que le facteur de transcription E2f1 joue un rôle important dans le maintien de l’identité transcriptomique et fonctionnelle des cellules β-pancréatiques.

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• Type de publi. : Article dans une revue
• Date de publi. : 22/03/2021
• Auteurs : Mélody PhilipponJean-Jacques CornéePhilippe MunchDouwe van HinsbergenMarcelle Boudagher-FadelLydie GaillerLydian BoschmanFrédéric QuillévéréLeny MontheilAurelien GayJean-Frédéric LebrunSerge LallemandLaurent MarivauxPierre-Olivier Antoine
• Organismes : Université des Antilles Géosciences Montpellier Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement
• Publié dans PLoS ONE le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 22/03/2021
• Auteurs : Mélody PhilipponJean-Jacques CornéePhilippe MunchDouwe van HinsbergenMarcelle Boudagher-FadelLydie GaillerLydian BoschmanFrédéric QuillévéréLeny MontheilAurelien GayJean-Frédéric LebrunSerge LallemandLaurent MarivauxPierre-Olivier Antoine
• Organismes : Université des Antilles
• Publié dans PLoS ONE le 25/10/2020

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• Type de publi. : Rapport
• Date de publi. : 20/03/2021
• Auteurs : Simon PageaudNicolas PonthusRomain GauchonCatherine PothierChristophe RigottiAnne Eyraud-LoiselJean-Pierre BertoglioAlexis BienvenüeFrançois GueyffierPhilippe VanhemsNicolas LeboisneJean IwazStéphane LoiselPascal Roy
• Organismes : Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Laboratoire de Tribologie et Dynamique des Systèmes Université Claude Bernard Lyon 1 Extraction de Caractéristiques et Identification Data Mining and Machine Learning Artificial Evolution and Computational Biology Laboratoire d'InfoRmatique en Image et Systèmes d'information Université Claude Bernard Lyon 1 Laboratoire de Mecanique des Fluides et d'Acoustique Université Claude Bernard Lyon 1 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Hospices Civils de Lyon Centre International de Recherche en Infectiologie Université Claude Bernard Lyon 1 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Université Claude Bernard Lyon 1 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon

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Résumé : The outbreak of SARS-CoV-2 virus has caused a major international health crisis with serious consequences in terms of public health and economy. In France, two lockdown periods were decided in 2020 to avoid the saturation of intensive care units (ICU) and an increase in mortality. The rapid dissemination of variant SARS-CoV-2 VOC 202012/01 has strongly influenced the course of the epidemic. Vaccines have been rapidly developed. Their efficacy against the severe forms of the disease has been established, and their efficacy against disease transmission is under evaluation. The aim of this paper is to compare the efficacy of several vaccination strategies in the presence of variants in controlling the COVID-19 epidemic through population immunity. An agent-based model was designed to simulate with different scenarios the evolution of COVID-19 pandemic in France over 2021 and 2022. The simulations were carried out ignoring the occurrence of variants then taking into account their diffusion over time. The expected effects of three Non-Pharmaceutical Interventions (Relaxed-NPI, Intensive-NPI, and Extended-NPI) to limit the epidemic extension were compared. The expected efficacy of vaccines were the values recently estimated in preventing severe forms of the disease (75% and 94%) for the current used vaccines in France (Pfizer-BioNTech and Moderna since January 11, 2021, and AstraZeneca since February 2, 2021). All vaccination campaigns reproduced an advanced age-based priority advised by the Haute Autorité de Santé. Putative reductions of virus transmission were fixed at 0, 50, 75 and 90%. The effects of four vaccination campaign durations (6-month, 12-month, 18-month and 24-month) were compared. In the absence of vaccination, the presence of variants led to reject the Relaxed-NPI because of a high expected number of deaths (170 to 210 thousands) and the significant overload of ICUs from which 35 thousand patients would be deprived. In comparison with the situation without vaccination, the number of deaths was divided by 7 without ICU saturation with a 6-month vaccination campaign. A 12-month campaign would divide the number of death by 3 with Intensive-NPI and by 6 with Extended-NPI (the latter being necessary to avoid ICU saturation). With 18-month and 24-month vaccination campaigns without Extended-NPI, the number of deaths and ICU admissions would explode. Among the four compared strategies the 6-month vaccination campaign seems to be the best response to changes in the dynamics of the epidemic due to the variants. The race against the COVID-19 epidemic is a race of vaccination strategy. Any further vaccination delay would increase the need of strengthened measures such as Extended-NPI to limit the number of deaths and avoid ICU saturation.

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Fichiers liés : Adapting French COVID-19 vaccination campaign v1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/03/2021
• Auteurs : Podjanee JittamalaWuelton MonteiroMenno R SmitBelen PedriqueSabine SpechtCarlos J ChaccourCéline DardPascal del GiudiceVirak KhieuA MaruaniVirgilio E Failoc-RojasMarimar Sáez-De-OcarizAntoni Soriano-ArandesJaime Piquero-CasalsAnne FaisantMarie-Pierre Brenier-PinchartDavid WimmersbergerJean T CoulibalyJennifer KeiserFranck BoraleviOliver SokanaMichael MarksDaniel EngelmanLucia RomaniAndrew C SteerLorenz von SeidleinNicholas J WhiteEli HarrissKasia StepniewskaGeorgina S HumphreysKalynn KennonPhilippe J GuerinKevin C Kobylinski
• Organismes : Centre Hospitalier de Basse-Terre [Guadeloupe] Centre Hospitalier Intercommunal Fréjus - St Raphaël methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire de Bordeaux
• Publié dans PLoS Neglected Tropical Diseases le 23/10/2020

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Résumé : Background Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg. Methodology/Principal findings A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for IPD guidelines by searching MEDLINE via PubMed, Web of Science, Ovid Embase, LILACS, Cochrane Database of Systematic Reviews, TOXLINE for all clinical trials, case series, case reports, and database entries for reports on the use of ivermectin in children weighing less than 15 kg that were published between 1 January 1980 to 25 October 2019. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017056515. A total of 3,730 publications were identified, 97 were selected for potential inclusion, but only 17 sources describing 15 studies met the minimum criteria which consisted of known weights of children less than 15 kg linked to possible adverse events, and provided comprehensive IPD. A total of 1,088 children weighing less than 15 kg were administered oral ivermectin for one of the following indications: scabies, mass drug administration for scabies control, crusted scabies, cutaneous larva migrans, myiasis, pthiriasis, strongyloidiasis, trichuriasis, and parasitic disease of unknown origin. Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported. Conclusions/Significance Existing limited data suggest that oral ivermectin in children weighing less than 15 kilograms is safe. Data from well-designed clinical trials are needed to provide further assurance.

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Fichiers liés : A systematic review and an individual.pdf

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• Type de publi. : Rapport
• Date de publi. : 16/03/2021
• Auteurs : Emilie GovalEmmanuelle AllartPierre AntoinePatrick AugusteJean-Jacques BahainPaule CoudretSylvie CoutardRudy DebiakPascal DepaepeLaurent DeschodtJean-Pierre FagnartPhilippe FerayCaroline FontDavid HérissonMarina PagliJessica LacarrièreJean‑luc LochtBertrand MassonOlivier MoineClément ParisNoémie SévêqueLuc Vallin
• Organismes : Histoire naturelle de l'Homme préhistorique Ministère de la Culture et de la Communication Ministère de la Culture et de la Communication Laboratoire de géographie physique : Environnements Quaternaires et Actuels Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 Histoire naturelle de l'Homme préhistorique Muséum national d'Histoire naturelle Institut national de recherches archéologiques préventives Laboratoire de géographie physique : Environnements Quaternaires et Actuels Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Histoire naturelle de l'Homme préhistorique Institut national de recherches archéologiques préventives Laboratoire de géographie physique : Environnements Quaternaires et Actuels Conseil général de la Somme - Centre archéologique départemental Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Centre National de la Recherche Scientifique Archéologies et Sciences de l'Antiquité Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène Ministère de la Culture et de la Communication Archéologies et Sciences de l'Antiquité Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène Archéologies et Sciences de l'Antiquité Institut national de recherches archéologiques préventives Laboratoire de géographie physique : Environnements Quaternaires et Actuels Ministère de la Culture et de la Communication Laboratoire de géographie physique : Environnements Quaternaires et Actuels Institut national de recherches archéologiques préventives Archéologies et Sciences de l'Antiquité Archéologies et Sciences de l'Antiquité Ministère de la Culture et de la Communication

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Résumé : Ce rapport de décompose en deux sections, la première rassemble la documentation administrative, la seconde rappelle la problématique générale du projet et présente les résultats obtenus lors de l’année en cours et le bilan. Sauf mention contraire en tête de chapitre les textes et la mise en page sont réalisés par Emilie Goval.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/03/2021
• Auteurs : Martin Pernot-BorràsJoel BergéPhilippe BraxJean-Philippe UzanGilles MetrisManuel Jorge RodriguesPierre Touboul
• Organismes : DPHY, ONERA, Université Paris Saclay [Châtillon] Institut d'Astrophysique de Paris DPHY, ONERA, Université Paris Saclay [Châtillon] Institut de Physique Théorique - UMR CNRS 3681 Institut d'Astrophysique de Paris Institut Lagrange de Paris Géoazur DPHY, ONERA, Université Paris Saclay [Châtillon] DPHY, ONERA, Université Paris Saclay [Châtillon]
• Publié dans Physical Review D le 02/11/2020

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Résumé : This article is dedicated to the use the MICROSCOPE mission’s data to test chameleon theory of gravity. We take advantage of the technical sessions aimed to characterize the electrostatic stiffness of MICROSCOPE’s instrument intrinsic to its capacitive measurement system. Any discrepancy between the expected and measured stiffness may result from unaccounted-for contributors, i.e., extra forces. This work considers the case of chameleon gravity as a possible contributor. It was previously shown that, in situations similar to these measurement sessions, a chameleon fifth force appears and acts as a stiffness for small displacements. The magnitude of this new component of the stiffness is computed over the chameleon’s parameter space. It allows us to derive constraints by excluding any force inconsistent with the MICROSCOPE data. As expected—since MICROSCOPE was not designed for the purpose of such an analysis—these new bounds are not competitive with state-of-the-art constraints, but they could be improved by a better estimation of all effects at play in these sessions. Hence, our work illustrates this novel technique as a new way of constraining fifth forces.

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Fichiers liés : 10.1103PhysRevD.103.064070.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/03/2021
• Auteurs : Inès Yoro-ZohounDismand Stephan HouinatoPhilippe NubukpoPascal MbelessoBébène Ndamba-BandzouziJean-Charles LambertJean-Pierre ClémentJean-François DartiguesPierre-Marie PreuxMaëlenn Guerchet
• Organismes : Epidémiologie des Maladies Chroniques en zone tropicale Neuroépidémiologie Tropicale Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Neuroépidémiologie Tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Neuroépidémiologie Tropicale et Comparée
• Publié dans International Psychogeriatrics le 31/10/2020

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Résumé : Objectives: To evaluate the association between neuropsychiatric symptoms and apolipoprotein E (APOE) ϵ4 allele among older people in Central African Republic (CAR) and the Republic of Congo (ROC). Design: Multicenter population-based study following a two-phase design. Setting: From 2011 to 2012, rural and urban areas of CAR and ROC. Participants: People aged 65 and over. Measurements: Following screening using the Community Screening Interview for Dementia, participants with low cognitive scores (CSI-D ≤ 24.5) underwent clinical assessment. Dementia diagnosis followed the DSM-IV criteria and Peterson's criteria were considered for Mild Cognitive Impairment (MCI). Neuropsychiatric symptoms were evaluated through the brief version of the Neuropsychiatric Inventory (NPI-Q). Blood samples were taken from all consenting participants before APOE genotyping was performed by polymerase chain reaction (PCR). Logistic regression models were used to evaluate the association between the APOE ϵ4 allele and neuropsychiatric symptoms. Results: Overall, 322 participants had complete information on both neuropsychiatric symptoms and APOE status. Median age was 75.0 years and 81.1% were female. Neuropsychiatric symptoms were reported by 192 participants (59.8%) and at least 1 APOE ϵ4 allele was present in 135 (41.9%). APOE ϵ4 allele was not significantly associated with neuropsychiatric symptoms but showed a trend toward a protective effect in some models. Conclusion: This study is the first one investigating the association between APOE ϵ4 and neuropsychiatric symptoms among older people in sub-Saharan Africa (SSA). Preliminary findings indicate that the APOE ϵ4 allele was not associated with neuropsychiatric symptoms. Further research seems, however, needed to investigate the protective trend found in this study.

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Fichiers liés : div-class-title-apolipoprotein-e-4-allele-and-neuropsychiatric-symptoms-among-older-adults-in-central-africa-epidemca-study-div.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/03/2021
• Auteurs : Elisa Le BoiteuxFranck CourtPierre‐Olivier GuichetCatherine Vaurs-BarrièreIsabelle VaillantE. ChautardPierre VerrelleBruno M CostaLucie Karayan-TaponAnne FogliPhilippe P. Arnaud
• Organismes : Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de neurosciences expérimentales et cliniques [U 1084] Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Laboratoire de neurosciences expérimentales et cliniques [U 1084] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Génétique, Reproduction et Développement
• Publié dans Molecular Oncology le 23/10/2020

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Fichiers liés : leboiteux 2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/03/2021
• Auteurs : Inès Yoro-ZohounDismand Stephan HouinatoPhilippe NubukpoPascal MbelessoBébène Ndamba-BandzouziJean-Charles LambertJean-Pierre ClémentJean-François DartiguesPierre-Marie PreuxMaëlenn Guerchet
• Organismes : Neuroépidémiologie Tropicale Laboratory of Chronic and Neurological Diseases Epidemiology Neuroépidémiologie Tropicale Laboratory of Chronic and Neurological Diseases Epidemiology Neuroépidémiologie Tropicale Pôle Universitaire d’Addictologie en Limousin Neuroépidémiologie Tropicale Neuroépidémiologie Tropicale Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Service de Psychiatrie [CHU Limoges] Neuroépidémiologie Tropicale Bordeaux population health Neuroépidémiologie Tropicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale Neuroépidémiologie Tropicale
• Publié dans International Psychogeriatrics le 31/10/2020

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Résumé : Objectives: To evaluate the association between neuropsychiatric symptoms and apolipoprotein E (APOE) ϵ4 allele among older people in Central African Republic (CAR) and the Republic of Congo (ROC). Design: Multicenter population-based study following a two-phase design. Setting: From 2011 to 2012, rural and urban areas of CAR and ROC. Participants: People aged 65 and over. Measurements: Following screening using the Community Screening Interview for Dementia, participants with low cognitive scores (CSI-D ≤ 24.5) underwent clinical assessment. Dementia diagnosis followed the DSM-IV criteria and Peterson's criteria were considered for Mild Cognitive Impairment (MCI). Neuropsychiatric symptoms were evaluated through the brief version of the Neuropsychiatric Inventory (NPI-Q). Blood samples were taken from all consenting participants before APOE genotyping was performed by polymerase chain reaction (PCR). Logistic regression models were used to evaluate the association between the APOE ϵ4 allele and neuropsychiatric symptoms. Results: Overall, 322 participants had complete information on both neuropsychiatric symptoms and APOE status. Median age was 75.0 years and 81.1% were female. Neuropsychiatric symptoms were reported by 192 participants (59.8%) and at least 1 APOE ϵ4 allele was present in 135 (41.9%). APOE ϵ4 allele was not significantly associated with neuropsychiatric symptoms but showed a trend toward a protective effect in some models. Conclusion: This study is the first one investigating the association between APOE ϵ4 and neuropsychiatric symptoms among older people in sub-Saharan Africa (SSA). Preliminary findings indicate that the APOE ϵ4 allele was not associated with neuropsychiatric symptoms. Further research seems, however, needed to investigate the protective trend found in this study.

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