Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Benoît BatailleJade de SellePierre-Etienne MoussotPhilippe MartyStein SilvaPierre Cocquet
• Organismes : Centre Hospitalier de Narbonne Centre Hospitalier de Narbonne Centre Hospitalier de Narbonne Clinique Médipôle Garonne Toulouse NeuroImaging Center Pôle Anesthésie Réanimation [CHU de Toulouse] Centre Hospitalier de Narbonne
• Publié dans British Journal of Anaesthesia le 28/10/2020

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Résumé : Background: Passive leg raising (PLR) predicts fluid responsiveness in critical illness, although restrictions in mobilising patients often preclude this haemodynamic challenge being used. We investigated whether machine learning applied on transthoracic echocardiography (TTE) data might be used as a tool for predicting fluid responsiveness in critically ill patients. Methods: We studied, 100 critically ill patients (mean age: 62 yr [standard deviation: 14]) with severe sepsis or septic shock prospectively over 24 months. Transthoracic echocardiography measurements were performed at baseline, after PLR, and before and after a standardised fluid challenge in learning and test populations (n=50 patients each). A 15% increase in stroke volume defined fluid responsiveness. The machine learning methods used were classification and regression tree (CART), partial least-squares regression (PLS), neural network (NNET), and linear discriminant analysis (LDA). Each method was applied offline to determine whether fluid responsiveness may be predicted from left and right cardiac ventricular physiological changes detected by cardiac ultrasound. Predictive values for fluid responsiveness were compared by receiver operating characteristics (area under the curve [AUC]; mean [95% confidence intervals]). Results: In the learning sample, the AUC values were PLR 0.76 (0.62-0.89), CART 0.83 (0.73-0.94), PLS 0.97 (0.93-1), NNET 0.93 (0.85-1), and LDA 0.90 (0.81-0.98). In the test sample, the AUC values were PLR 0.77 (0.64-0.91), CART 0.68 (0.54-0.81), PLS 0.83 (0.71-0.96), NNET 0.83 (0.71-0.94), and LDA 0.85 (0.74-0.96) respectively. The PLS model identified inferior vena cava collapsibility, velocity-time integral, S-wave, E/Ea ratio, and E-wave as key echocardiographic parameters. Conclusions: Machine learning generated several models for predicting fluid responsiveness that were comparable with the haemodynamic response to PLR.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Arthur BergerFederico RavaioliOana FarcauDavide FestiHoria StefanescuFrançois BuissonNathalie Ganne-CarrièAnnalisa BerzigottiSalvatore PettaSylvie Sacher HuvelinDominique VallaChristophe BureauAnne OlivierFrédéric ObertiJérôme BoursierJean Paul GalmicheJean Pierre VinelClotilde DuburqueAlain AttarIsabelle ArchambeaudR. BenamouzigMarianne GaudricDominique LuetPatrice CouzigouLucie PlancheEmmanuel CoronJean-Baptiste HiriartFaiza ChermakMaude CharbonnierPierre NahonPatrick MarcellinDominique GuyaderStanislas PolHélène FontaineDominique LarreyVictor de LedinghenDenis OuzanFabien ZoulimDominique RoulotAlbert TranJean-Pierre BronowickiJean-Pierre ZarskiVincent LeroyGhassan RiachiPaul CalèsJean-Marie PéronLaurent AlricMarc BourlièrePhilippe MathurinSebastien DharancyJean-Frédéric BlancArmand AbergelLawrence SerfatyAriane MallatJean-Didier GrangéPierre AttaliYannick BacqClaire WartelleThông DaoYves BenhamouChristophe PiletteChristine SilvainChristos ChristidisDominique CapronGérard ThiefinSophie HillaireVincent Di Martino
• Organismes : Centre Hospitalier Universitaire d'Angers Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Alma Mater Studiorum Università di Bologna = University of Bologna Regional Institute of Gastroenterology and Hepatology [Cluj-Napoca] Alma Mater Studiorum Università di Bologna = University of Bologna Regional Institute of Gastroenterology and Hepatology [Cluj-Napoca] Centre Hospitalier Universitaire d'Angers Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Hôpital Jean Verdier [AP-HP] Centre de Recherche des Cordeliers Université Paris 13 Hôpital Cochin [AP-HP] UFR Médecine [Santé] - Université Paris Cité
• Publié dans Clinical Gastroenterology and Hepatology le 30/10/2020

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Résumé : Background & aims: Based on platelets and liver stiffness measurements, the Baveno VI criteria (B6C), the expanded B6C (EB6C), and the ANTICIPATE score can be used to rule out varices needing treatment (VNT) in patients with compensated chronic liver disease. We aimed to improve these tests by including data on the ratio of platelets to liver stiffness.Methods: In a retrospective analysis of data from 10 study populations, collected from 2004 through 2018, we randomly assigned data from 2368 patients with chronic liver disease of different etiologies to a derivation population (n = 1579; 15.1% with VNT, 50.2% with viral hepatitis, 28.9% with nonalcoholic fatty liver disease, 20.8% with alcohol-associated liver disease, with model for end-stage liver disease scores of 9.5 ± 3.0, and 93.0% with liver stiffness measurements ≥10 kPa) or a validation population (n = 789). Test results were compared with results from a sequential algorithm (VariScreen). VariScreen incorporated data on platelets or liver stiffness measurements and then the ratio of platelets to liver stiffness measurement, adjusted for etiology, patient sex, and international normalized ratio.Results: In the derivation population, endoscopies were spared for 23.9% of patients using the B6C (VNT missed in 2.9%), 24.3% of patients using the ANTICIPATE score (VNT missed in 4.6%), 34.5% of patients using VariScreen (VNT missed in 2.9%), and 41.9% of patients using the EB6C (VNT missed in 10.9%). Differences in spared endoscopy rates were significant (P ≤ .001), except for B6C vs ANTICIPATE and in missed VNT only for EB6C vs the others (P ≤ .009). VariScreen was the only safe test regardless of sex or etiology (missed VNT ≤5%). Moreover, VariScreen secured screening without missed VNT in patients with model for end-stage liver disease scores higher than 10. This overall strategy performed better than a selective strategy restricted to patients with compensated liver disease. Test performance and safety did not differ significantly among populations.Conclusions: In a retrospective study of data from 2368 patients with chronic liver disease, we found that the B6C are safe whereas the EB6C are unsafe, based on missed VNT. The VariScreen algorithm performed well in patients with chronic liver disease of any etiology or severity. It is the only test that safely rules out VNT and can be used in clinical practice.

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Fichiers liés : S1542356520308338.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Yohan SantinSébastien LopezIsabelle AderSandrine AndrieuNicolas BlanchardAudrey CarrièreLouis CasteillaBéatrice CousinNoélie DavezacPhilipe Barreto de SoutoCedric DrayNicolas FazilleauDaniel Gonzalez-DuniaPierre GourdySophie Gillette-GuyonnetNabila Jabrane-FerratOksana KunduzovaFrank Lezoualc’hRoland S LiblauLaurent O MartinezCédric MoroPierre PayouxLuc PénicaudValérie Planat-BénardClaire RamponYves RollandJoost-Peter SchanstraFelipe SierraPhilippe P. ValetAudrey VarinNathalie VergnolleBruno VellasJosé ViñaBruno GuiardAngelo Parini
• Organismes : Institut des Maladies Métaboliques et Casdiovasculaires Centre de Recherches sur la Cognition Animale - UMR5169 Centre de Biologie Intégrative STROMALab Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Institut du Vieillissement Centre de Physiopathologie Toulouse Purpan STROMALab STROMALab STROMALab Centre de Recherches sur la Cognition Animale - UMR5169 Centre de Biologie Intégrative Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Institut du Vieillissement Institut des Maladies Métaboliques et Casdiovasculaires Centre de Physiopathologie Toulouse Purpan Centre de Physiopathologie Toulouse Purpan Institut des Maladies Métaboliques et Casdiovasculaires Institut du Vieillissement Gérontopôle Centre de Physiopathologie Toulouse Purpan Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Centre de Physiopathologie Toulouse Purpan Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Toulouse NeuroImaging Center STROMALab STROMALab Centre de Recherches sur la Cognition Animale - UMR5169 Centre de Biologie Intégrative Institut du Vieillissement Gérontopôle Institut des Maladies Métaboliques et Casdiovasculaires National Institute on Aging [Bethesda, USA] Institut des Maladies Métaboliques et Casdiovasculaires STROMALab Institut de Recherche en Santé Digestive Gérontopôle Epidémiologie et Analyses en Santé Publique : risques, maladies chroniques et handicap Universitat de València = University of Valencia = Universidade de Valencia Centre de Recherches sur la Cognition Animale - UMR5169 Centre de Biologie Intégrative Institut des Maladies Métaboliques et Casdiovasculaires
• Publié dans The Journal of Frailty & Aging le 24/10/2020

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Résumé : Aging is the major risk factor for the development of chronic diseases. After decades of research focused on extending lifespan, current efforts seek primarily to promote healthy aging. Recent advances suggest that biological processes linked to aging are more reliable than chronological age to account for an individual's functional status, i.e. frail or robust. It is becoming increasingly apparent that biological aging may be detectable as a progressive loss of resilience much earlier than the appearance of clinical signs of frailty. In this context, the INSPIRE program was built to identify the mechanisms of accelerated aging and the early biological signs predicting frailty and pathological aging. To address this issue, we designed a cohort of outbred SWISS mice (1576 male and female mice) in which we will continuously monitor spontaneous and voluntary physical activity from 6 to 24 months of age under either normal or high fat/high sucrose diet. At different age points (6, 12, 18, 24 months), multiorgan functional phenotyping will be carried out to identify early signs of organ dysfunction and generate a large biological fluids/feces/organs biobank (100,000 samples). A comprehensive correlation between functional and biological phenotypes will be assessed to determine: 1) the early signs of biological aging and their relationship with chronological age; 2) the role of dietary and exercise interventions on accelerating or decelerating the rate of biological aging; and 3) novel targets for the promotion of healthy aging. All the functional and omics data, as well as the biobank generated in the framework of the INSPIRE cohort will be available to the aging scientific community. The present article describes the scientific background and the strategies employed for the design of the INSPIRE Mouse cohort.

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Fichiers liés : INSPIRE Mouse cohort.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Pilar AldaManon LounnasAntonio VazquezRolando AyaquiManuel CalvopiñaMaritza Celi-ErazoRobert T DillonLuisa Carolina González RamírezEric LokerJenny Muzzio-ArocaAlberto Orlando NárvaezOscar NoyaAndrés Esteban PereiraLuiggi Martini RoblesRichar Rodríguez-HidalgoNelson UribePatrice DavidPhilippe JarneJean-Pierre PointierSylvie Hurtrez-Boussès
• Organismes : Universidad Nacional del Sur [Argentina] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Pedro Kouri Institute of Tropical Medicine Universidad La Salle [Arequipa, Perú] Universidad de Las Américas [Ecuador] Universidad Central del Ecuador Auteur indépendant Universidad Nacional de Chimborazo The University of New Mexico [Albuquerque] Instituto Nacional de Investigación en Salud Pública [Guayaquil, Ecuador] Instituto Nacional de Investigación en Salud Pública [Guayaquil, Ecuador] Universidad Agraria del Ecuador Universidad Central de Venezuela Universidad Industrial de Santander [Bucaramanga] Auteur indépendant Universidad Central del Ecuador Universidad Industrial de Santander [Bucaramanga] Centre d’Ecologie Fonctionnelle et Evolutive Centre d’Ecologie Fonctionnelle et Evolutive Centre de recherches insulaires et observatoire de l'environnement Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
• Publié dans Molecular Phylogenetics and Evolution le 31/10/2020

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Résumé : Cryptic species can present a significant challenge to the application of systematic and biogeographic principles, especially if they are invasive or transmit parasites or pathogens. Detecting cryptic species requires a pluralistic approach in which molecular markers facilitate the detection of coherent taxonomic units that can then be analyzed using various traits (e.g., internal morphology) and crosses. In asexual or self-fertilizing species, the latter criteria are of limited use. We studied a group of cryptic freshwater snails (genus Galba) from the family Lymnaeidae that have invaded almost all continents, reproducing mainly by self-fertilization and transmitting liver flukes to humans and livestock. We aim to clarify the systematics, distribution, and phylogeny of these species with an integrative approach that includes morphology, molecular markers, wide-scale sampling across America, and data retrieved from GenBank (to include Old World samples). Our phylogenetic analysis suggests that the genus Galba originated ca. 22 Myr ago and today comprises six species or species complexes. Four of them show an elongated-shell cryptic phenotype and exhibit wide variation in their genetic diversity, geographic distribution, and invasiveness. The remaining two species have more geographically restricted distributions and exhibit a globose-shell cryptic phenotype, most likely phylogenetically derived from the elongated one. We emphasize that no Galba species should be identified without molecular markers. We also discuss several hypotheses that can explain the origin of cryptic species in Galba, such as convergence and morphological stasis.

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Fichiers liés : Alda et al_Last version_2020_MPE.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/04/2021
• Auteurs : Giovanna TinettiPaul EcclestonCarole HaswellPierre-Olivier LagageJérémy LeconteTheresa LüftingerGiusi MicelaMichel MinGöran PilbrattLudovic PuigMark SwainLeonardo TestiDiego TurriniBart VandenbusscheMaria Rosa Zapatero OsorioAnna AretJean-Philippe BeaulieuLars BuchhaveMartin FerusMatt GriffinManuel GüdelPaul HartoghPedro MachadoGiuseppe MalagutiEnric PalléMirek RatajTom RayIgnasi RibasRobert SzabóJonathan TanStephanie WernerFrancesco RattiCarsten ScharmbergJean-Christophe SalvignolNathalie BoudinJean-Philippe HalainMartin HaagPierre-Elie CrouzetRalf KohleyKate SymondsFlorian RenkAndrew CaldwellManuel AbreuGustavo AlonsoJerome AmiauxMichel BerthéGeorgia BishopNeil BowlesDeirdre CoffeyJosep ColoméMartin CrookLucile DésjonqueresJosé J. DíazRachel DrummondMauro FocardiJose M. GómezWarren HolmesMatthijs KrijgerZsolt KovacsTom HuntRichardo MachadoGianluca MorganteMarc OllivierRoland OttensamerEmanuele PaceTeresa PaganoEnzo PascaleChris PearsonSøren Møller PedersenMoshe PnielStéphane RooseGiorgio SaviniRichard StamperPeter SziroviczaJanos SzokeIan ToshFrancesc VilardellJoanna BarstowLuca BorsatoSarah CasewellBenjamin CharnaySvatopluk CivišVincent Coudé Du ForestoAthena CoustenisNicolas CowanCamilla DanielskiO. DemangeonPierre DrossartBilly N. EdwardsGabriella GilliTherese EncrenazCsaba KissAnastasia KokoriMasahiro IkomaJuan Carlos MoralesJoão MendonçaAndrea MonetiLorenzo MugnaiAntonio García MuñozRavit HelledMihkel KamaYamila MiguelNikos NikolaouIsabella PaganoOlja PanicMiriam RengelHans RickmanMarco RocchettoSubhajit SarkarJascha SchewtschenkoJ. TennysonAngelos TsiarasOlivia VenotKrisztián VidaIngo P. WaldmannSergey YurchenkoGyula SzabóRob ZellemAhmed Al-RefaieJavier Perez AlvarezLara AnismanAxel ArhancetJaume AtecaRobin BaeyensJohn R. BarnesTaylor BellSerena BenattiKatia BiazzoMaria BłęckaAldo Stefano BonomoJosé BoschDiego BossiniJérémy BourgalaisDaniele BrienzaAnna BrucalassiGiovanni BrunoHamish CainesSimon CalcuttTiago CampanteRodolfo CanestrariNick CannGiada CasaliAlbert CasasGiuseppe CassoneChristophe CaraManuel CarmonaLudmila CaroneNathalie CarrascoQuentin ChangeatPaolo ChioettoFausto CortecchiaMarkus CzupallaKaty L. ChubbAngela CiaravellaAntonio ClaretRiccardo ClaudiClaudio CodellaMaya Garcia ComasGianluca CracchioloPatricio CubillosVania da PeppoLeen DecinClemence DejabrunElisa Delgado-MenaAnna Di GiorgioEmiliano DiolaitiCaroline DornVanessa DoublierEric DoumayrouGeorgina DransfieldLuc DumayeEmma DunfordAntonio Jimenez EscobarVincent van EylenMaria FarinaDavide FedeleAlejandro FernándezBenjamin FleurySergio FonteJean FontignieLuca FossatiBernd FunkeCamille GalyZoltán GaraiAndrés GarcíaAlberto García-RigoAntonio GarufiGiuseppe Germano SaccoPaolo GiacobbeAlejandro GómezArturo GonzalezFrancisco Gonzalez-GalindoDavide GrassiCaitlin GriffithMario Giuseppe GuarcelloAudrey GoujonAmélie GressierAleksandra GrzegorczykTristan GuillotGloria GuilluyPeter HargraveMarie-Laure HellinEnrique HerreroMatt HillsBenoit HoreauYuichi ItoNiels Christian JessenPetr KabathSzilárd KálmánYui KawashimaTadahiro KimuraAntonín KnížekLaura KreidbergRonald KruidDiederik J. M. KruijssenPetr KubelíkLuisa LaraSébastien LebonnoisDavid LeeMaxence LefèvreTim LichtenbergDaniele LocciMatteo LombiniAlejandro Sanchez LopezAndrea LorenzaniRyan MacdonaldLaura MagriniJesus MaldonadoEmmanuel MarcqAlessandra MiglioriniDarius Modirrousta-GalianKaran MolaverdikhaniSergio MolinariPaul MollièreVincent MoreauGiuseppe MorelloGilles MorinaudMario MorvanJulianne I. MosesSalima MouzaliNariman NakhjiriLuca NaponielloNorio NaritaValerio NascimbeniAthanasia NikolaouVladimiro NoceFabrizio OlivaPietro PalladinoAndreas PapageorgiouVivien ParmentierGiovanni PeresJavier PérezSantiago Perez-HoyosManuel PergerCesare Cecchi PestelliniAntonino PetraliaAnne PhilipponArianna PiccialliMarco PignatariGiampaolo PiottoLinda PodioGianluca PolentaGiampaolo PretiTheodor PribullaManuel Lopez PuertasMonica RainerJean-Michel ReessPaul RimmerSéverine RobertAlbert RosichLoïc RossiDuncan RustAyman SalehNicoletta SannaEugenio SchisanoLaura SchreiberVictor SchwartzAntonio ScippaBálint SeliSho ShibataCaroline SimpsonOliver ShorttleNour SkafKonrad SkupMateusz SobieckiSergio SousaAlessandro SozzettiJudit ŠponerLukas SteigerPaolo TangaPaul TackleyJake TaylorMatthias TeczaLuca TerenziPascal TremblinAndrea TozziAmaury TriaudLoïc TrompetShang-Min TsaiMaria TsantakiDiana ValenciaAnn Carine VandaeleMathieu van Der SwaelmenAdibekyan VardanGautam VasishtAllona VazanCiro del VecchioDave WalthamPiotr WawerThomas WidemannPaulina WolkenbergGordon Hou YipYuk YungMantas ZilinskasTiziano ZingalesPaola Zuppella
• Organismes : University College London [UCL] Space Science and Technology Department [Didcot] Université de Bordeaux Agence Spatiale Européenne = European Space Agency SRON Netherlands Institute for Space Research Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Jet Propulsion Laboratory Istituto di Astrofisica e Planetologia Spaziali - INAF Catholic University of Leuven = Katholieke Universiteit Leuven Institut d'Astrophysique de Paris INAF - Osservatorio Astronomico di Bologna Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Agence Spatiale Européenne = European Space Agency Space Science and Technology Department [Didcot] Commissariat à l'énergie atomique et aux énergies alternatives Commissariat à l'énergie atomique et aux énergies alternatives Space Science and Technology Department [Didcot] Space Science and Technology Department [Didcot] Space Science and Technology Department [Didcot] Jet Propulsion Laboratory SRON Netherlands Institute for Space Research INAF - Osservatorio Astronomico di Bologna Institut d'astrophysique spatiale Space Science and Technology Department [Didcot] Jet Propulsion Laboratory University College London [UCL] Space Science and Technology Department [Didcot] Space Science and Technology Department [Didcot] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Institut d'Astrophysique de Paris University College London [UCL] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Institut d'Astrophysique de Paris University College London [UCL] SRON Netherlands Institute for Space Research University College London [UCL] Université de Bordeaux University College London [UCL] University College London [UCL] Laboratoire Interuniversitaire des Systèmes Atmosphériques University College London [UCL] University College London [UCL] Jet Propulsion Laboratory University College London [UCL] University College London [UCL] Catholic University of Leuven = Katholieke Universiteit Leuven PLANETO - LATMOS Istituto di Astrofisica e Planetologia Spaziali - INAF University College London [UCL] Space Science and Technology Department [Didcot] Commissariat à l'énergie atomique et aux énergies alternatives PLANETO - LATMOS University College London [UCL] INAF - Osservatorio Astronomico di Bologna SRON Netherlands Institute for Space Research Catholic University of Leuven = Katholieke Universiteit Leuven INAF - Osservatorio Astronomico di Bologna University College London [UCL] Istituto di Astrofisica e Planetologia Spaziali - INAF Jet Propulsion Laboratory Istituto di Astrofisica e Planetologia Spaziali - INAF Istituto di Astrofisica e Planetologia Spaziali - INAF University College London [UCL] SRON Netherlands Institute for Space Research Jet Propulsion Laboratory Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics INAF - Osservatorio Astronomico di Bologna PLANETO - LATMOS Istituto di Astrofisica e Planetologia Spaziali - INAF Istituto di Astrofisica e Planetologia Spaziali - INAF University College London [UCL] Istituto di Astrofisica e Planetologia Spaziali - INAF Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics PLANETO - LATMOS University College London [UCL] Istituto di Astrofisica e Planetologia Spaziali - INAF INAF - Osservatorio Astronomico di Bologna Space Science and Technology Department [Didcot] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics INAF - Osservatorio Astronomico di Bologna Jet Propulsion Laboratory Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Istituto di Astrofisica e Planetologia Spaziali - INAF University College London [UCL]

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Résumé : Ariel, the Atmospheric Remote-sensing Infrared Exoplanet Large-survey, was adopted as the fourth medium-class mission in ESA's Cosmic Vision programme to be launched in 2029. During its 4-year mission, Ariel will study what exoplanets are made of, how they formed and how they evolve, by surveying a diverse sample of about 1000 extrasolar planets, simultaneously in visible and infrared wavelengths. It is the first mission dedicated to measuring the chemical composition and thermal structures of hundreds of transiting exoplanets, enabling planetary science far beyond the boundaries of the Solar System. The payload consists of an off-axis Cassegrain telescope (primary mirror 1100 mm x 730 mm ellipse) and two separate instruments (FGS and AIRS) covering simultaneously 0.5-7.8 micron spectral range. The satellite is best placed into an L2 orbit to maximise the thermal stability and the field of regard. The payload module is passively cooled via a series of V-Groove radiators; the detectors for the AIRS are the only items that require active cooling via an active Ne JT cooler. The Ariel payload is developed by a consortium of more than 50 institutes from 16 ESA countries, which include the UK, France, Italy, Belgium, Poland, Spain, Austria, Denmark, Ireland, Portugal, Czech Republic, Hungary, the Netherlands, Sweden, Norway, Estonia, and a NASA contribution.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Pierre JourdainBenoit BrillandOuassim MedhioubJeanne CaronClément SamoreauAssia DjemaRenaud GanseyJean-Philippe CoindreMaud CousinAnne Sophie GarnierNicolas HenrySamuel WacrenierJeremy RiouGiorgina Barbara PiccoliJf Augusto
• Organismes : Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Innate Immunity and Immunotherapy Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Micro et Nanomédecines Translationnelles Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Service de Néphrologie [CH Cholet] Service de néphrologie [CH Laval] Centre Hospitalier Le Mans (CH Le Mans) Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Service de néphrologie [CH Laval] Département de Néphrologie-Dialyse-Transplantation [CHU Angers] Centre Hospitalier Le Mans (CH Le Mans) Innate Immunity and Immunotherapy Centre Hospitalier Universitaire d'Angers Service de néphrologie [CH Laval] Dipartimento di Scienze cliniche e biologiche [Torino, Italy] Innate Immunity and Immunotherapy Département de Néphrologie-Dialyse-Transplantation [CHU Angers]
• Publié dans Kidney International Reports le 26/10/2020

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Résumé : No abstract available

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Fichiers liés : 1-s2.0-S2468024920318714-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Jean-Jacques CorneePhilippe MunchMélody PhilipponMarcelle Boudagher-FadelFrédéric QuillévéréMihaela Melinte-DobrinescuJean-Frédéric LebrunAurélien GaySolène MeyerLeny MontheilSerge LallemandB. MarcaillouMuriel LaurencinLucie LegendreClément GarrocqMilton BoucardMarie-Odile BeslierMireille LaigleLaure ScheniniPierre-Henri FabrePierre-Olivier AntoineLaurent Marivaux
• Organismes : Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Géosciences Montpellier Université des Antilles Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Cardiac Unit, Institute of Child Health Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement National Institute of Marine Geology and Geoecology (Romania) Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Géosciences Montpellier Université des Antilles Géosciences Montpellier Géoazur Université des Antilles Géosciences Montpellier Université des Antilles Géosciences Montpellier Université des Antilles Géoazur Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Géosciences Montpellier Université des Antilles (Pôle Guadeloupe) Géosciences Montpellier Université des Antilles Géosciences Montpellier Université des Antilles Géoazur Géoazur Géoazur Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier
• Publié dans Earth-Science Reviews le 22/10/2020

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Résumé : Our study aims to reconstruct the palaeogeography of the northern part of the Lesser Antilles in order to analyse whether emerged areas might have existed during the Cenozoic, favouring terrestrial faunal dispersals between South America and the Greater Antilles along the present-day Lesser Antilles arc. The stratigraphy and depositional environments of the islands of Anguilla, St Martin, Tintamarre, St Barthélemy, Barbuda and Antigua are reviewed in association with multichannel reflection seismic data acquired offshore since the 80's in the Saba, Anguilla and Antigua Banks and in the Kalinago Basin, including the most recent academic and industrial surveys. Seven seismic megasequences and seven regional unconformities are defined, and calibrated from deep wells on the Saba Bank and various dredges performed during marine cruises since the 70's in the vicinity of the islands. Onshore and offshore correlations allow us to depict an updated and detailed sedimentary organisation of the northern part of the Lesser Antilles from the late Eocene to the late Pleistocene. Paleogeographic reconstructions reveal sequences of uplift and emergence across hundredswide areas during the late Eocene, the late Oligocene, the early middle-Miocene and the latest Miocene-earliest Pliocene, interspersed by drowning episodes. The ∼200 km-long and ∼20 km-wide Kalinago Basin opened as an intra-arc basin during the late Eocene-early Oligocene. These periods of emergence may have favoured the existence of episodic mega-islands and transient

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Fichiers liés : The northern Lesser Antilles hal.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Pauline Lasserre-ZuberMarianne ChavéeMarlène FaureSylvie RocheOlivier SoudièreJérôme MuttererJean-Philippe MaignelEmilien PoussetPatricia LemMartin LerembourePierre P. DevauxFrédérique SerreValerie CadotCyrille Saintenac
• Organismes : Génétique Diversité et Ecophysiologie des Céréales Génétique Diversité et Ecophysiologie des Céréales Groupe d'Etude et de contrôle des Variétés Et des Semences Unité Expérimentale PHénotypage Au Champ des Céréales (UE1375) Unité Expérimentale PHénotypage Au Champ des Céréales (UE1375) Institut de Biologie Moléculaire des Plantes Groupe d'Etude et de contrôle des Variétés Et des Semences BioGEVES BioGEVES Institut de Chimie de Clermont-Ferrand Florimond Desprez Unité Expérimentale PHénotypage Au Champ des Céréales (UE1375) Groupe d'Etude et de contrôle des Variétés Et des Semences Génétique Diversité et Ecophysiologie des Céréales
• Publié dans Innovations Agronomiques le 24/10/2020

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Résumé : La contamination des grains par les mycotoxines et notamment le deoxynivalenol (DON) est un problème sanitaire majeur chez les céréales. Cette étude a permis de comparer un ensemble exhaustif de méthodologies pour évaluer le taux de grains symptomatiques suite à une attaque de Fusarium graminearum et la contamination des farines par le DON pour permettre une évaluation en routine de ces caractères dans les programmes de sélection. Grace à ces nouvelles méthodologies, le projet a également mis en avant sept régions du génome de blé impliquées dans la résistance aux DON ainsi que des marqueurs moléculaires utilisables en sélection pour construire des variétés plus résistantes, un enjeu prioritaire pour la filière céréalière

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Fichiers liés : 2021_Lassere-Zuber_InnovAgro_Vol84.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Alexis CourtyPierre MedrelTibault ReveyrandPhilippe BouysseJean-Michel NebusGeoffroy Soubercaze-Pun
• Organismes : Ampleon Systèmes RF XLIM Systèmes RF Systèmes RF Centre National d'Études Spatiales [Toulouse]
• Publié dans International Journal of Microwave and Wireless Technologies le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2021
• Auteurs : Viet-Thi TranMatthieu MahévasFirouze Bani-SadrOlivier RobineauThomas PerpointElodie PerrodeauLaure GallayPhilippe H. RavaudFrançois GoehringerFrançois-Xavier LescureSophie IsmaëlCédric LaouénanJennifer SoulierOriane PuéchalEric D’ortenzioYazdan YazdanpanahLaurence MaulinStéphanie MartinezDiane SanderinkPascale FialaireSéverine AnsartLucas PerezAnne DestremChloé MoulinPascal GicquelFrédéric RivièreMartin MartinotMahsa Mohseni ZadehTomasz ChroboczekThibaut Challan BelvalLionel PirothThibault SixtFlorian MorettoAndré CabiéJérémie PasquierOrnella CabrasMarine MorrierJean ReuterThomas HeninPierre BraquetHelene Desmurs-ClavelArnaud HotBoris BienvenuBelkacem AsselateNicolas VignierSteve NgualaSylvain DiamantisGuillemette FrémontPierre Louis NivoseMathilde ThiébautBenjamin LefevreHélène AugePaul Le TurnierNaila BenkalfateOlivier GrossiSamuel PineauElisa DemonchyJulie MerindolClaire DurandNathalie TieuliéViviane QueyrelDidier LaureillardPaul LoubetSégolène GreffeNathalie DournonYoussouf Mohamed KassimCyrille GourjaultAlexandre LahensPaul LegendreCaroline MorbieuGiovanna MelicaJean-Daniel LevièvreFrédéric SchlemmerSimone TunesiClaire LeblancAnne Bourgarit-DurandAlexandre BleibtreuGianpiero TebanoJérôme PacanowskiJean-Benoit ZabbeMathilde DevauxLaurent BellecMarine Gosset-WoimantCéleste LambertMaxime HentzienAmélie ServettazKévin AlexandreManuel EtienneRomain LéguillonMarion DollatRémi LefrancoisAnne PouvaretYvon RuchYannick DieudonnéGuillaume Martin-BlondelXavier BoumazaMargaux LafaurieMacha TetartAdrien LemaignenNicole Ferreira-MaldentAmélie DuréaultMarie GousseffClaire ChantepieFrancesca BisioFanny PommeretEmeline Colomba BlambleClaire Ara Somohano
• Organismes : Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Hôpital Henri Mondor Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Tourcoing Hospices Civils de Lyon Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Hôpital Edouard Herriot [CHU - HCL] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Service des Maladies Infectieuses et Tropicales [CHRU Nancy] Services de Maladies Infectieuses et Tropicales [CHU Bichat] Pathogenesis and Control of Chronic and Emerging Infections Fort de France, Centre Hospitalo-Universitaire Martinique, Service des Maladies Infectieuses et Tropicales, France Pathogenesis and Control of Chronic and Emerging Infections Fort de France, Centre Hospitalo-Universitaire Martinique, Service des Maladies Infectieuses et Tropicales, France Institut Toulousain des Maladies Infectieuses et Inflammatoires Service Maladies infectieuses et tropicales [CHU Toulouse] Service Maladies infectieuses et tropicales [CHU Toulouse] Centre d'investigation clinique de Toulouse Service Pharmacologie Clinique [CHU Toulouse]
• Publié dans Clinical Microbiology and Infection le 30/10/2020

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Résumé : Objective: To assess the effectiveness of corticosteroids on outcomes of patients with coronavirus disease 2019 (COVID-19) pneumonia requiring oxygen without mechanical ventilation. Methods: We used routine care data from 51 hospitals in France and Luxembourg to assess the effectiveness of corticosteroids at 0.8 mg/kg/day eq. prednisone (CTC group) versus standard of care (no-CTC group) among adults 18-80 years old with confirmed COVID-19 pneumonia requiring oxygen without mechanical ventilation. The primary outcome was intubation or death by day 28. In our main analysis, characteristics of patients at baseline (i.e. time when patients met all inclusion criteria) were balanced by using propensity-score inverse probability of treatment weighting. Results: Among the 891 patients included in the analysis, 203 were assigned to the CTC group. Use of corticosteroids was not significantly associated with risk of intubation or death by day 28 (weighted hazard ratio (wHR) 0.92, 95%CI 0.61-1.39) nor cumulative death rate (wHR 1.03, 95%CI 0.54-1.98). However, use of corticosteroids was associated with reduced risk of intubation or death by day 28 in the prespecified subgroups of patients requiring oxygen >3 L/min (wHR 0.50, 95%CI 0.30-0.85) or C-reactive protein level >100 mg/L (wHR 0.44, 95%CI 0.23-0.85). The number of hyperglycaemia events was higher for patients with corticosteroids than for those without, but the number of infections was similar. Conclusions: We found no association between the use of corticosteroids and intubation or death in the broad population of patients 18-80 years old, with COVID-19, hospitalized in settings non intensive care units. However, the treatment was associated with a reduced risk of intubation or death for patients with >3 L/min oxygen or C-reactive protein level >100 mg/L at baseline. Further research is needed to confirm the right timing for corticosteroids in patients with COVID-19 requiring oxygen only.

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Fichiers liés : S1198743X2030731X.pdf

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