Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Pierre PayouxJean‐philippe Ranjeva
• Organismes : Toulouse NeuroImaging Center Centre Hospitalier Universitaire de Toulouse Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM]
• Publié dans Thérapie le 29/10/2020

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Résumé : This manuscript reviews the contributions of the neuroimaging methods including PET, conventional and advanced MRI methods to monitor the effect of new disease modifying drugs in neurodegenerative diseases. It now seems obvious that in many pathologies these two techniques are more and more complementary.

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Fichiers liés : S0040595720302250.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Christelle EliasAbel SekriPierre LeblancMichel CucheratPhilippe Vanhems
• Organismes : Centre International de Recherche en Infectiologie Université Claude Bernard Lyon 1 Fondation Mérieux Hôpital de la Croix-Rousse [CHU - HCL] Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hospices Civils de Lyon Research on Healthcare Performance Evaluation et modélisation des effets thérapeutiques [LBBE] Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI]
• Publié dans International Journal of Infectious Diseases le 31/10/2020

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Fichiers liés : S1201971221000813.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Pierre-Louis TharauxGilles PialouxArthur PavotXavier MarietteOlivier HermineMatthieu Resche-RigonRaphaël PorcherPhilippe H. RavaudSerge BureauMaxime DougadosAnnick TibiÉlie AzoulayJacques CadranelJoseph EmmerichMuriel FartoukhBertrand GuidetGiovanna MarazziKarine LacombeMatthieu MahevasFrédéric PeneValérie Pourchet-MartinezFrédéric SchlemmerYazdan YazdanpanahGabriel BaronElodie PerrodeauDamien VanhoyeCécile KedziaLauren DemervilleAnne Gysembergh-HoualAlexandre BourgoinSarah DalibeyNabil RakedLakhdar MameriStéphanie AlarySamir HamiriaThinhinane BarizHala SemriDhiaa Meriem HaiMoustafa BenaflaMohamed BelloulPernelle VauboinSaskia FlamandClaire PachecoAnouk Walter-PetrichEmilia StanSouad BenarabCorine NyanouClaire MontlahucLucie BiardRobin CharreteurCeline DupréKévin CardetBlandine LehmannKamyl BaghliClaire MadelaineEric d'OrtenzioOriane PuéchalCaroline SemailleLaurent SavaleAnatole HarroisSamy FigueiredoJacques DuranteauNadia AnguelXavier MonnetChristian RichardJean-Louis TeboulP. DurandPierre TissieresMitja JevnikarDavid MontaniSophie BulifonXavier JaïsOlivier SitbonStéphan PavyNicolas NoelOlivier LambotteLelia EscautStéphane JauréguiberryElodie BaudryChristiane VernyMathilde NoaillonEdouard LefèvreMohamad ZaidanClotilde Le Tiec Le TiecCéline Verstuyft VerstuyftAnne-Marie RoquesLamiae GrimaldiDomitille MolinariGaël LeprunAlain FourreauLaurent CyllyMyriam VirlouvetRamdane MeftaliSolène FabreMarion LicoisAsmaa MamouneYacine BoudaliSophie Georgin-LaviallePatricia SenetA. SoriaAntoine ParrotHélène FrançoisNathalie RozensztajnEmmanuelle BlinPascaline ChoinierJuliette CamusetJean-Simon RechAntony CanellasCamille Rolland-DebordNadège LemariéNicolas BelaubeMarine NadalMartin SiguierCamille Petit-HoangJulie ChasElodie DrouetMatthieu LemoineAudrey PhibelLucie AunayEliane BertrandSylviane RavatoMarie VayssettesAnne AddaCeline WilpottePélagie ThibautJulie FillonIsabelle DebrixSoraya FellahiJean-Philippe BastardGuillaume LefèvreVincent FalletJacques-Eric GottenbergYves HansmannEmmanuel AndrèsSophie BayerGuillaume BeckerFrédéric BlancStéphane BrinVincent CastelainEmmanuel ChatelusEva ChatronOlivier CollangeFrançois DanionFrédéric de BlayEric DemonsantPierre DiemunschSophie DiemunschRenaud FeltenBernard GoichotValentin GreigertAurélien GuffroyBob HegerAnne HuttCharlotte KaeufferLoic KassegneAnne Sophie KorganowPierrick Le BorgneNicolas LefebvreTristan MartinPaul Michel MertesCatherine MetzgerNicolas MeyerGabriel NisandEric NollMathieu OberlinSophie Ohlmann-CaillardVincent PoindronJulien PottecherYvon RuchCédric SublonHakim TayebiFrançois WeillArsène MékinianDorothée ChopinOlivier FainMarc GarnierJessica Krause Le GarrecMarjolaine MorgandJerome PacanowskiTomas UrbinaChloe McavoyMaria PereiraGladys AratusLaurence BerardTabassome SimonAnne Daguenel-NguyenMarie AntignacCéline LeplayJean-Benoit ArletJean-Luc DiehlFlorence BellenfantAnne BlanchardAlexandre BuffetBernard CholleyAntoine FayolEdouard FlamarionAnne GodierThomas GorgetSophie-Rym HamadaCaroline Hauw-BerlemontJean-Sébastien HulotDavid LebeauxMarine LivrozetAdrien MichonArthur NeuschwanderMarie-Aude PenetBenjamin PlanquetteBrigitte RanqueOlivier SanchezGeoffroy VolleSandrine BrioisMathias CornicVirginie EliseeDenis, JesuthasanJuliette Djadi-PratPauline JouanyRamon JunqueraMickael HenriquesAmina KebirIsabelle LehirJeanne MeunierFlorence PatinValérie PaquetAnne TréhanVéronique VignaBrigitte SabatierDamien BergerotCharléne JouveCamille KnospOlivia LenoirNassim MahtalLéa ResminiF-Xavier LescureJade GhosnAntoine BachelardTimothee BironneRaphaël BorieAgathe BounhiolCatherine BoussardJeanne ChauffierSolaya ChalalLynda ChalalMalikhone ChansombatPaul CrespinBruno CrestaniOlivia DaconceicaoLaurene DeconinckPhilippe DieudeAntoine DossierMarie DubertGreggory DucrocqAxelle FuentesAnne GervaisMarie GilbertValentina IserniaSophie IsmaelVeronique JolyZelie JuliaSylvie LarivenSylvie Le GacDiane Le PluartFrancoise LouniAwa NdiayeThomas PapoMarion PariseyBao PhungAnnabelle PourbaixAnne RachlineChristophe RiouxAurelie SautereauPhilippe Gabriel StegHassan TarhiniSimon ValayerDorothee ValloisPaul VermesThomas VolpeYann NguyenVasco HonselEmmanuel WeissAnaïs CodorniuVirginie ZarroukVictoire de LastoursMatthieu UzzanOlivier OlivierGeoffrey RossiNaura GamanyRoza RahliZeina LouisDavid BoutboulLionel GalicierYaël AmaraGabrielle ArcherAmira BenattiaAnne BergeronLouise BondeelleNathalie de CastroMelissa ClémentMichaël DarmontBlandine DenisClairelyne DupinElsa FeredjDelphine FeyeuxAdrien JosephEtienne LenglinéPierre Le GuenGeoffroy LiégeonGwenaël LorillonAsmaa MabroukiEric MariotteGrégoire Martin de FrémontAdrien MirouseJean-Michel MolinaRégis Peffault de LatourÉric OksenhendlerJulien SaussereauAbdellatif TaziJean-Jacques TudesqLara ZafraniIsabelle BrindeleEmmanuelle BugnetKarine Celli LebrasJulien ChabertLalia DjaghoutCatherine FauvauxAnne Lise JeguEwa KozaliewiczMartine MeunierMarie-Thérèse TremorinClaire DavoineIsabelle MadeleineSophie Caillat-ZucmanConstance DelaugerreFlorence MorinDamien SèneRuxandra BurlacuBenjamin ChoustermanBruno MégarbaneP. RichetteJean-Pierre RivelineAline FrazierÉric VicautLaure BertonTassadit HadjamMiguel Alejandro Vasquez-IbarraClément JourdaineAude JacobJulie SmatiStéphane RenaudPhilippe ManivetClaire PerninLydia SuarezLuca SemeranoSébastien AbadRuben BenainousCoralie Bloch QueyratNicolas BonnetSabrina BrahmiJohann CailholYves CohenCeline ComparonHugues CordelRobin DhoteNathalie DournonBoris DuchemannNathan EbsteinBenedicte Giroux-LeprieurJeanne Goupil de BouilleAnne JacolotHilario NunesJohanna OzielVanessa RathouinMarthe RigalDominique RoulotClaire TantetYurdagül UzunhanNathalie Costedoat-ChalumeauZakaria Ait HamouSarah BenghanemPhilippe BlancheEtienne CanouiNicolas CarlierBenjamin ChaigneAdrien ContejeanBertrand DunoguePierre DuplandAurélie Durel - MaurisseRémy GauzitPaul JaubertHassan JoumaaMathieu JozwiakSolen KernéisMarie LachatreHélène LafoestePaul LegendreLiem Binh Luong NguyenJonathan MareyCaroline MorbieuLuc MouthonLee NguyenLola-Jade PalmieriAlexis RégentTali-Anne SzwebelBenjamin TerrierCorinne GuerinJérémie ZerbitKahina CherefKamil ChitourMamadou Salif CisseAda ClarkeGaelle ClavereIsabelle DusanterCaroline GaudefroyMoez JallouliSami KoltaCatherine Le BourloutNathalie MarinNathalie MenageAlexandre MooresIsabelle PeigneyCédric PierronSamira Saleh-MghirMathilde ValletMarc MichelGiovanna MelicaJean-Daniel LelievreElena FoisPascal LimMarie MatignonConstance GuillaudAlaki ThiemeleDavid SchmitzMarion BouhrisSyllia BelazouzLaetitia LanguilleArmand Mekontso-DessapsThiziri SadaouiJulien MayauxPatrice CacoubJean-Christophe CorvolCéline LouapreSara SambinLouise-Laure MarianiKirsten Müller-VahlFlorence TubachCandice EstellatLinda GimenoKarine MartinAïcha BahVixra KeoSabrine OuamriYasmine MessaoudiNessima YellesPierre FayeSébastien CavelotCecile LarchevequeLaurence AnnonayJaouad BenhidaAida Zahrate-GhoulSoumeya HammalRidha BelilitaMarie LecronierAlexandra BeurtonLuc HaudebourgRobin DelerisJulien Le MarecSara VirolleSafaa NemlaghiCôme BureauPierre MoraMartin de SarcusOlivier ClovetBaptiste DuceauPaul Henri GrisotMarie Hélène PariJérémy ArzoineUlrich ClaracMorgane FaureJulie DelemazureMaxence DecaveleElise MorawiecAlexandre DemouleMartin DresMathieu VautierYves AllenbachOlivier BenvenisteGaelle LerouxAude RigoletPerrine Guillaume-JugnotFanny DomontAnne Claire DesboisCloé ComarmondNicolas ChamptiauxSegolene ToquetAmine GhembazaMatheus VieiraGeorgina MaaloufGonçalo BoletoYasmina FerfarFanny CharbonnierClaire AguilarFanny Alby-LaurentMarie-Alexandra AlyanakianPrissile BakouboulaChristine BroissandCarole BurgerClara Campos-VegaNathalie ChavarotLaure ChoupeauxBenjamin FournierSophie GranvilleElodie IssoratClaire RouzaudDamien VimpereGuillaume GeriNawal DerridjNaima SguiouarHakim MeddahMourad DjadelHelene Chambrin-LauvrayJean-Charles Duclos-ValléeFaouzi SalibaSophie-Caroline SacleuxIlias KoumisJean-Marie MichotAnnabelle StoclinEmeline ColombaFanny PommeretChistophe WillekensMadona SakkalRosa da SilvaValérie DejeanYasmina MekidInes Ben-MabroukCaroline PradonLaurence DrouardValérie Camara-ClayetteAlexandre MorelGilles GarciaAbolfazl MohebbiFérial BerbourMélanie DehaisAnne-Lise PouliquenAlison KlasenLoren Soyez-HerkertJonathan LondonYounes KeroumiEmmanuelle GuillotGuillaume GraillesYounes El AmineFanny DefrancqHanane FodilChaouki BourasDominique DautelNicolas GambierThierno DieyeAnaïs RazurelBoris BienvenuVictor LanconLaurence LecomteKristina BeziriganyanBelkacem AsselateLaure AllanicElena KiourisMarie-Hélène LegrosChristine LemagnerPascal MartelVincent ProvitoloFélix AckermannMathilde Le MarchandAurélie Clan Hew WaiDimitri FremontElisabeth CoupezMireille AddaFrédéric DuéeLise BernardAntoine GrosEstelle HenryClaire CourtinAnne PattynPierre-Grégoire GuinotMarc BardouAgnes MaurerJulie JambonAmélie Cransac-MietCorinne PernotBruno MourvillierAmélie ServettazGaetan DesléeAlain WynckelPhilippe BenoitEric MarquisDamien RouxCoralie GernezCécile YelnikJulien PoissyMandy NizardFanette DeniesHélène GrosJean-Jacques MouradEmmanuelle SaccoSophie Renet
• Organismes : Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Assistance publique - Hôpitaux de Paris (AP-HP) Université Paris Cité Optimisation thérapeutique en Neuropsychopharmacologie Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière] Centre de recherche en Myologie – U974 SU-INSERM Centre de recherche en Myologie – U974 SU-INSERM
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Résumé : Background: Patients with COVID-19 pneumonia have an excess of inflammation and increased concentrations of cytokines including interleukin-1 (IL-1). We aimed to determine whether anakinra, a recombinant human IL-1 receptor antagonist, could improve outcomes in patients in hospital with mild-to-moderate COVID-19 pneumonia. Methods: In this multicentre, open-label, Bayesian randomised clinical trial (CORIMUNO-ANA-1), nested within the CORIMUNO-19 cohort, we recruited patients from 16 University hospitals in France with mild-to-moderate COVID-19 pneumonia, severe acute respiratory syndrome coronavirus 2 infection confirmed by real-time RT-PCR, requiring at least 3 L/min of oxygen by mask or nasal cannula but without ventilation assistance, a score of 5 on the WHO Clinical Progression Scale (WHO-CPS), and a C-reactive protein serum concentration of more than 25 mg/L not requiring admission to the intensive care unit at admission to hospital. Eligible patients were randomly assigned (1:1) using a web-based secure centralised system, stratified by centre and blocked with varying block sizes (randomly of size two or four), to either usual care plus anakinra (200 mg twice a day on days 1-3, 100 mg twice on day 4, 100 mg once on day 5) or usual care alone. Usual care was provided at the discretion of the site clinicians. The two coprimary outcomes were the proportion of patients who had died or needed non-invasive or mechanical ventilation by day 4 (ie, a score of >5 on the WHO-CPS) and survival without need for mechanical or non-invasive ventilation (including high-flow oxygen) at day 14. All analyses were done on an intention-to-treat basis. The trial is registered with ClinicalTrials.gov, NCT04341584, and is now closed to accrual. Findings: Between April 8 and April 26, 2020, we screened 153 patients. The study was stopped early following the recommendation of the data and safety monitoring board, after the recruitment of 116 patients: 59 were assigned to the anakinra group, and 57 were assigned to the usual care group. Two patients in the usual care group withdrew consent and were not analysed. In the analysable population, the median age was 66 years (IQR 59 to 76) and 80 (70%) participants were men. In the anakinra group, 21 (36%) of 59 patients had a WHO-CPS score of more than 5 at day 4 versus 21 (38%) of 55 in the usual care group (median posterior absolute risk difference [ARD] -2·5%, 90% credible interval [CrI] -17·1 to 12·0), with a posterior probability of ARD of less than 0 (ie, anakinra better than usual care) of 61·2%. At day 14, 28 (47%; 95% CI 33 to 59) patients in the anakinra group and 28 (51%; 95% CI 36 to 62) in the usual care group needed ventilation or died, with a posterior probability of any efficacy of anakinra (hazard ratio [HR] being less than 1) of 54·5% (median posterior HR 0·97; 90% CrI 0·62 to 1·52). At day 90, 16 (27%) patients in the anakinra group and 15 (27%) in the usual care group had died. Serious adverse events occurred in 27 (46%) patients in the anakinra group and 21 (38%) in the usual care group (p=0·45). Interpretation: Anakinra did not improve outcomes in patients with mild-to-moderate COVID-19 pneumonia. Further studies are needed to assess the efficacy of anakinra in other selected groups of patients with more severe COVID-19. Funding: The Ministry of Health, Programme Hospitalier de Recherche Clinique, Foundation for Medical Research, and AP-HP Foundation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Thomas SanniéPhilippe de MoerlooseBrigitte AlbertLudovic AnaniClaire ArcéTatiana Priscilla BagloCheikh BahaydeMohamed Abdallahi BollahiJean‐michel BouchezSabine CastetIrene ChamiBernard DavietAbdou Ramane DialloMaimouna DialloMaryse DienSaliou DiopAlexis Elira DokekiasGaetan DuportJean‐françois DuportGini EhunguAloys FashahoMohamhed Wenne FeilNorbert FerréChristian FondanescheNicolas GiraudYves GruelJean‐christophe GrisErwan GuillouAssad HaffarEleonore KafandoAimable KanyamunhungaGuelor KatendiDorothée KindeGueth KundabiMichel Du Laurent de La BarreAlain Marques Marques‐verdierSalomé MekhuzlaMaguy MichaudSylvestre MulindabyumaJames NdahayoYacouba NébiéJean‐paul NgoukoulouFabrice PilorgéClaire PouplardNicolas de PoursacOlivat Alson RakotoAnne RymanOlivia Romero‐luxFrançois SauvêtreGhislaine SawadogoJean‐françois SchvedEmmanuel SerombaBouna SowDiariatou Sy‐bahBrigitte Tardy-PoncetCatherine TernisienPierre ToulonMarc TrossaertDavid VirenqueAlain WeillEkhtel Benina ZeinAlban ZohounAristide ZongoAugustin Zoungrana
• Organismes : Université de Genève = University of Geneva
• Publié dans Haemophilia le 25/10/2020

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Résumé : Introduction: There is a lack of joint recommendations by healthcare professionals (HCP) and patient organizations when a partnership between high and low-income countries in the field of haemophilia is planned. Aim: To draft recommendations to clarify the methodology when a partnership between low- and high-income countries is planned with the objective of a long-term implication. This methodology is to be implemented for fulfilling both medical and associative aims. Methods: Based on the available literature, a first document was written, then diffused to AFATH (Alliance Franco-Africaine pour le Traitement de l'Hémophilie) members, and after a one-day meeting and further amendments, a second draft was approved by all members before submission for publication. Results: Based on 6 years experience, several recommendations regarding the joint and separate roles of patient association and HCP for a first mission in French-speaking sub-Saharan African countries have been established. The proposed methodology for establishing preliminary contacts, the first visit and the key points for diagnostic action, medical follow-up, patient education and advocacy strategy outlines a model of partnership between patients and HCP. Conclusion: This paper written jointly by patients and physicians underlines the importance of reciprocal expert guidance and a partnership based on complementary inputs.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Tim HarrisonPascal ChanezFrancesco MenzellaGiorgio Walter CanonicaRenaud LouisBorja CosioNjira LugogoArjun MohanAnnie BurdenLawrence McdermottEsther Garcia GilJames ZangrilliWolfgang PohlRobert VovesMaud DeschampheleireRenaud LouisJean-Benoit MartinotRudi PechéKenneth ChapmanAmarjit CheemaDelbert DorscheidJ. Mark FitzgeraldRemi GagnonWilliam Patrick KillornRonald OlivensteinGeorge PhilteosClare RamseyJ. Douglass RolfBrandie WalkerOle HilbergTina SkjoldIngrid TitlestadAuli HakulinenMaritta KilpeläinenMichèle Ben HayounPhilippe BonniaudArnaud BourdinPascal ChanezFrédéric De BlayGaëtan DesleeGilles DevouassouxAlain DidierYoucef DouadiStéphanie FryGilles GarciaPierre-Olivier GirodetChristophe LeroyerAntoine MagnanGuillaume MahayCécilia NocentChristophe PisonPauline-Marie RouxCamille TailléJuliana-Angelica TiotiuEkkehard BeckMargret JandlChristian KaehlerFrank KässnerFrank KoestersJuliane KronsbeinThomas SchaumChristian SchulzDirk SkowaschChristian TaubeTobias WelteAndrés de RouxBianca BeghéFrancesco BlasiGiorgio Walter CanonicaGiovanna CarpagnanoCristiano CarusoAngelo Guido CorsicoElio ConstantinoNunzio CrimiPiero MaestrelliFrancesco MenzellaManlio MilaneseAlberto PapiGirolamo PelaiaLaura PiniPierachille SantusEleonora SaviNicola ScichiloneGianenrico SennaGiuseppe SpadaroAdriano VaghiSteven GansJurgen HöltersB. LangeveldWillem PietersG.H.A. StaaksIlonka van VeenJ.W.K. van den BergGunnar EinvikSverre LehmannIsmael Ali GarcíaCarlos AlmonacidIrina BoboleaPaloma Campo MozoGustavo de LuizChristian Domingo RibasJosé María Echave-Sustaeta María-ToméJuan Luis García RiveroBorja García-Cosío PiquerasAna Gómez-Bastero FernándezRuperto González PérezAythamy Henríquez SantaCarlos Martínez RiveraXavier Muñoz GallJacinto RamosJose Gregorio Soto CamposCarmen Vidal PanNikolai StenforsAlf TunsäterInes VingeRekha ChaudhuriTimothy HarrisonAdel MansurShuaib NasserMonica NordstromPaul PfefferDinesh SaralayaPhilip ShortArun AdlakhaOral AlpanFrancis AverillAnil BadhwarJose BardelasBarbara BaxterGeorge BenschWilliam BergerJonathan BernsteinTracy BridgesRyan BrimeyerWilliam CalhounEdward CampbellWilliam Brett CherryGeoffrey ChuppLee CloreJohn CohnJeremy ColeJohn CondemiJames CuryBenjamin DavisSamuel DeleonLuis DelacruzJoseph DiazDavid ErbEmeka EziriFaisal FakihDouglas FiedlerDavid FostStephen FritzErika GonzalezBrad GoodmanPeter GottliebGregory GottschlichRichard GowerRizan HajalJames HarrisHengameh Heidarian-RaissyAlbrecht HeyderDavid HillFernando HolguinIftikhar HussainJonathan IllowiteJoshua JacobsMikell JarrattHarold KaiserNeil KaoRavindra KashyapDavid KaufmanEdward KentKenneth KimRyan KleinMonica KraftRitsu KonoShahrukh KureishyJeffrey LefleinMila LeongHuamin LiRobert LinNjira LugogoMichael MarcusDiego Jose Maselli CaceresVinay MehtaCurtis MelloMark MillardAaron MilstoneArjun MohanWendy MooreMark MossNayla MumnehThomas O'BrienDavid OstranskyMichael PalumboPurvi ParikhSudhir ParikhAmit PatelGuido PerezWarren PleskowBruce PrennerDileep PuppalaJohn RameyJoan ReibmanRamon ReyesEmory RobinetteIleana RodicioStephen RyanSudhir SekhsariaBarry SigalVinay SikandWeily SoongSelwyn SpangenthalRoy St. JohnGary StevenVijay SubramaniamKaharu SuminoEric SztejmanRicardo TanTonny TanusCharles ThompsonCarl ThornbladeManuel VillarealSally WenzelHeidi ZafraTomasz Ziedalski
• Organismes : Virologie et Immunologie Moléculaires Service de pneumologie [Hôpital Foch] Université de Versailles Saint-Quentin-en-Yvelines
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Sophie CaillardNathalie ChavarotHélène FrancoisMarie MatignonClarisse GrezeNassim KamarPhilippe GataultOlivier ThaunatTristan LegrisLuc FrimatPierre-François WesteelValentin GoutaudierMariam JdidouRenaud SnanoudjCharlotte ColosioAntoine SicardDominique BertrandChristiane MoussonJamal BamoulidChristophe MassetAntoine ThierryLionel CouziJonathan Maurice M ChemounyAgnes DuveauValerie MoalGilles BlanchoPhilippe GrimbertAntoine DurrbachBruno MoulinDany AnglicheauYvon RuchCharlotte KaeufferIlies BenotmaneMorgane SolisYannick LemeurMarc HazzanFrancois Danion
• Organismes : Centre Hospitalier Universitaire [Strasbourg] Immuno-Rhumatologie Moléculaire Institut Necker Enfants-Malades CHU Tenon [AP-HP] Institut Mondor de Recherche Biomédicale CHU Henri Mondor [Créteil] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Hospitalier Universitaire de Toulouse Université de Tours Hôpital Edouard Herriot [CHU - HCL] Centre International de Recherche en Infectiologie Cellules B normales et pathogéniques - Normal and pathogenic B cell responses [CIRI] Université Claude Bernard Lyon 1 Service de Transplantation, Néphrologie et Immunologie Clinique [Lyon] Aix Marseille Université Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy Service de Néphrologie [CHRU Nancy] CHU Amiens-Picardie CHU Montpellier = Montpellier University Hospital Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hôpital universitaire Robert Debré [Reims] Unité de Recherche Clinique Côte d’Azur Hôpital Pasteur [Nice] Université de Rouen Normandie Université de Bourgogne Université de Franche-Comté Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Université de Poitiers = University of Poitiers Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle CHU de Bordeaux Pellegrin [Bordeaux] Centre d'Investigation Clinique [Rennes] Institut de recherche en santé, environnement et travail Université d'Angers Aix Marseille Université Hôpital de la Conception [CHU - APHM] Microbes Evolution Phylogénie et Infections Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut Mondor de Recherche Biomédicale CHU Henri Mondor [Créteil] Institut Mondor de Recherche Biomédicale CHU Henri Mondor [Créteil] Immuno-Rhumatologie Moléculaire Centre Hospitalier Universitaire [Strasbourg] Institut Necker Enfants-Malades Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire [Strasbourg] Immuno-Rhumatologie Moléculaire Centre Hospitalier Universitaire [Strasbourg] Immuno-Rhumatologie Moléculaire Lymphocytes B, Autoimmunité et Immunothérapies CHRU Brest - Service de Nephrologie LabEX IGO Immunothérapie Grand Ouest Université de Lille Centre Hospitalier Universitaire [Strasbourg]
• Publié dans American Journal of Transplantation le 26/10/2020

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Résumé : There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients and nontransplant patients. We enrolled two groups of patients hospitalized for COVID-19, that is, kidney transplant recipients (KTR) from the French Registry of Solid Organ Transplant (n = 306) and a single-center cohort of nontransplant patients (n = 795). An analysis was performed among subgroups matched for age and risk factors for severe COVID-19 or mortality. Severe COVID-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death. Transplant recipients were younger and had more comorbidities compared to nontransplant patients. They presented with higher creatinine levels and developed more episodes of acute kidney injury. After matching, the 30-day cumulative incidence of severe COVID-19 did not differ between KTR and nontransplant patients; however, 30-day COVID-19-related mortality was significantly higher in KTR (17.9% vs 11.4%, respectively, p = .038). Age >60 years, cardiovascular disease, dyspnea, fever, lymphopenia, and C-reactive protein (CRP) were associated with severe COVID-19 in univariate analysis, whereas transplant status and serum creatinine levels were not. Age >60 years, hypertension, cardiovascular disease, diabetes, CRP >60 mg/L, lymphopenia, kidney transplant status (HR = 1.55), and creatinine level >115 µmol/L (HR = 2.32) were associated with COVID-19-related mortality in univariate analysis. In multivariable analysis, cardiovascular disease, dyspnea, and fever were associated with severe disease, whereas age >60 years, cardiovascular disease, dyspnea, fever, and creatinine level>115 µmol/L retained their independent associations with mortality. KTR had a higher COVID-19-related mortality compared to nontransplant hospitalized patients

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Fichiers liés : Caillard et al- 2020 - Is Covid-19 infection more severe in kidney transplant recipients.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Pascal PujolMassimo BarberisPhilp BeerEitan FriedmanJosep M PiulatsEttore D CapoluongoJesus Garcia FoncillasIsabelle Ray-CoquardFrédérique Penault-LlorcaWilliam FoulkesClare TurnbullHelen HansonSteven NarodBanu K ArunMatti S AaproJean-Louis MandelNicola NormannoDiether LambrechtsIgnace VergoteMichèle AnahoryBernard BaertschiKaren BaudryYves-Jean BignonMarc BolletCarole CorsiniOlivier CussenotThibault de La Motte RougeMarie Duboys de LabarreFlorence DuchampClarisse DuriezKarim FizaziVirginie GalibertLaurence GladieffJoseph GligorovPascal HammelMarion Imbert-BouteilleWilliam JacotTatiana Kogut-KubiakPierre-Jean LamyDaphné LehalleYann NeuzilletSylviane OlschwangXavier RébillardJean-Marc ReyChloé RideauJean-Philippe SpanoFrédéric ThomasIsabelle TreilleuxMarion VandrommeJulie VendrellMichèle VintraudDaniel ZarcaKevin S HughesMichèle VintraudJose E Alés Martínez
• Organismes : Centre de Recherches Ecologiques et Evolutives sur le Cancer European Institute of Oncology [Milan] The Wellcome Trust Sanger Institute [Cambridge] Chaim Sheba Medical Center Tel Aviv University CEINGE Biotecnologie Avanzate s.c.a.r.l. Health Service and Performance Research Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Department of Human Genetics [Montréal] McGill University = Université McGill [Montréal, Canada] The Institute of Cancer Research Queen Mary University of London The Royal Marsden NHS Foundation Trust [London] The Institute of Cancer Research University of Toronto The University of Texas M.D. Anderson Cancer Center [Houston] Institut de Génétique et de Biologie Moléculaire et Cellulaire VIB-KU Leuven Center for Cancer Biology Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Comité d'éthique de l'Inserm = The Inserm Ethics Committee Université de Genève = University of Geneva Centre Hospitalier Régional Universitaire [Montpellier] Centre Jean Perrin [Clermont-Ferrand] Imagerie Moléculaire et Stratégies Théranostiques Institut Rafaël Centre Hospitalier Régional Universitaire [Montpellier] Groupe de Recherche Clinique Onco-Urologie Prédictive Centre de Recherche pour les Pathologies Prostatiques [Paris] University of Oxford Chemistry, Oncogenesis, Stress and Signaling CRLCC Eugène Marquis Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut Gustave Roussy Oncologie génito-urinaire [Gustave Roussy] Centre Hospitalier Régional Universitaire [Montpellier] Oncopole Claudius Regaud Pôle IUCT [CHU Toulouse] CHU Tenon [AP-HP] Institut Universitaire de Cancérologie [Sorbonne Université] Hôpital Beaujon [AP-HP] Centre Hospitalier Régional Universitaire [Montpellier] Institut régional de Cancérologie de Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Clinique Beau Soleil [Montpellier] Lipides - Nutrition - Cancer [Dijon - U1231] Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon) UFR Sciences de la santé Simone Veil Marseille medical genetics - Centre de génétique médicale de Marseille Clinique Beau Soleil [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Epidémiologie, Systèmes d'Information, Modélisation CHU Pitié-Salpêtrière [AP-HP] Centre de Recherches Ecologiques et Evolutives sur le Cancer Centre Léon Bérard [Lyon] Institut de Recherche en Cancérologie de Montpellier Harvard Medical School [Boston]
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé : BRCA1 and BRCA2 gene pathogenic variants account for most hereditary breast cancer and are increasingly used to determine eligibility for PARP inhibitor (PARPi) therapy of BRCA-related cancer. Because issues of BRCA testing in clinical practice now overlap with both preventive and therapeutic management, updated and comprehensive practice guidelines for BRCA genotyping are needed. The integrative recommendations for BRCA testing presented here aim to (1) identify individuals who may benefit from genetic counselling and risk-reducing strategies; (2) update germline and tumour-testing indications for PARPi-approved therapies; (3) provide testing recommendations for personalised management of early and metastatic breast cancer; and (4) address the issues of rapid process and tumour analysis. An international group of experts, including geneticists, medical and surgical oncologists, pathologists, ethicists and patient representatives, was commissioned by the French Society of Predictive and Personalised Medicine (SFMPP). The group followed a methodology based on specific formal guidelines development, including (1) evaluating the likelihood of BRCAm from a combined systematic review of the literature, risk assessment models and expert quotations, and (2) therapeutic values of BRCAm status for PARPi therapy in BRCA-related cancer and for management of early and advanced breast cancer. These international guidelines may help clinicians comprehensively update and standardise BRCA testing practices.

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Fichiers liés : Pujol-2021-Clinical practice guidelines for BRCA1 and BRCA2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Sophie GarnierMagdalena HarakalovaStefan WeissMichal MokryVera Regitz-ZagrosekChristian HengstenbergThomas CappolaRichard IsnardEloisa ArbustiniStuart CookJessica van SettenJorg CalisHakon HakonarsonMichael MorleyKlaus StarkSanjay PrasadJin LiDeclan O'ReganMaurizia GrassoMartina Müller-NurasyidThomas MeitingerJean‐philippe EmpanaKonstantin StrauchMelanie WaldenbergerKenneth MarguilesChristine SeidmanGeorgios KararigasBenjamin MederJan HaasPierre BoutouyriePatrick LacolleyXavier JouvenJeanette ErdmannStefan BlankenbergThomas WichterVolker RuppertLuigi TavazziOlivier DubourgGérard RoizesRichard DorentPascal de GrooteLaurent FauchierJean-Noël TrochuJean-François AupetitZofia BilinskaMarine GermainUwe VölkerDaiane HemerichIbticem RajiDelphine Bacq-DaianCarole ProustPaloma RemiorManuel Gomez-BuenoKristin LehnertRenee MaasRobert OlasoGanapathi Varma SaripellaStephan FelixSteven McginnLaëtitia Duboscq-BidotAlain van MilCéline BesseVincent FontaineHélène BlanchéFlavie AderBrendan KeatingAngélique CurjolAnne BolandMichel KomajdaFrançois CambienJean‐françois DeleuzeMarcus DörrFolkert W AsselbergsEric VillardDavid-Alexandre TrégouëtPhilippe CharronCarl SemaanArthur CharbonnierJeremy PascoWalid DarwicheChristophe Saint EtienneXavier BailleulThierry BourguignonDenis AngoulvantFabrice IvanesThibaud Genet
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases University Medical Center [Utrecht] Universität Greifswald = University of Greifswald German Center for Cardiovascular Research University Medical Center [Utrecht] Charité - UniversitätsMedizin = Berlin University Medicine German Center for Cardiovascular Research University of Pennsylvania [Philadelphia] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Istituti di Ricovero e Cura a Carattere Scientifico National Heart Centre Singapore University Medical Center [Utrecht] University Medical Center [Utrecht] Children’s Hospital of Philadelphia University of Pennsylvania [Philadelphia] Universität Regensburg = University of Regensburg = Université de Ratisbonne [Allemagne] Royal Brompton Hospital [London, United Kingdom] Children’s Hospital of Philadelphia Imperial College London Istituti Clinici Scientifici Maugeri [Pavia] Helmholtz Zentrum München = German Research Center for Environmental Health Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University CHU Trousseau [Tours] Éducation Éthique Santé Centre Hospitalier Régional Universitaire de Tours CHU Trousseau [Tours] Université de Tours CHU Trousseau [Tours] CHU Trousseau [Tours] Centre Hospitalier Régional Universitaire de Tours Transplantation, Immunologie, Inflammation [Tours] Transplantation, Immunologie, Inflammation [Tours] CHU Trousseau [Tours]
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : Although many risk models have been tested in patients implanted by veno-arterial extracorporeal membrane oxygenation (VA-ECMO), few scores assessed patients’ prognosis in the setting of ST-segment elevation myocardial infarction (STEMI) with refractory cardiogenic shock. We aimed at assessing the performance of risk scores, notably the prEdictioN of Cardiogenic shock OUtcome foR AMI patients salvaGed by VA-ECMO (ENCOURAGE) score, for predicting mortality in this particular population. This retrospective observational study included patients admitted to Tours University Hospital for STEMI with cardiogenic shock and requiring hemodynamic support by VA-ECMO. Among the fifty-one patients, the 30-day and 6-month survival rates were 63% and 56% respectively. Thirty days after VA-ECMO therapy, probabilities of mortality were 12, 17, 33, 66, 80% according to the ENCOURAGE score classes 0–12, 13–18, 19–22, 23–27, and ≥28, respectively. The ENCOURAGE score (AUC of the Receiving Operating Characteristic curve = 0.83) was significantly better compared to other risk scores. The hazard ratio for survival at 30 days for each point of the ENCOURAGE score was 1.10 (CI 95% (1.06, 1.15); p < 0.001). Decision curve analysis indicated that the ENCOURAGE score had the best clinical usefulness of the tested risk scores and the Hosmer–Lemeshow test suggested an accurate calibration. Our data suggest that the ENCOURAGE score is valid and the most relevant score to predict 30-day mortality after VA-ECMO therapy in STEMI patients with refractory cardiogenic shock. It may help decision-making teams to better select STEMI patients with shock for VA-ECMO therapy.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Alexandre MilmanStéphanie VenteoJean-Louis BossuPierre FontanaudArnaud MonteilPhilippe LoryNathalie C. Guérineau
• Organismes : Institut de Génomique Fonctionnelle Institut des Neurosciences de Montpellier Institut des Neurosciences Cellulaires et Intégratives Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle
• Publié dans The Journal of Physiology le 29/10/2020

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Résumé : Chromaffin cells (CCs) are the master neuroendocrine units for the secretory function of the adrenal medulla and a finely-tuned regulation of their electrical activity is required for appropriate catecholamine secretion in response to the organismal demand. Here, we aim at deciphering how the spiking pattern of mouse CCs is regulated by the ion conductances operating near the resting membrane potential (RMP). At RMP, mouse CCs display a composite firing pattern, alternating between active periods composed of action potentials spiking with a regular or a bursting mode, and silent periods. RMP is sensitive to changes in extracellular sodium concentration, and a low Na+ -containing saline hyperpolarizes the membrane, regardless of the discharge pattern. This RMP drive reflects the contribution of a depolarizing conductance, which is (i) not blocked by tetrodotoxin or caesium, (ii) displays a linear I-V relationship between -110 and -40 mV, and (iii) is carried by cations with a conductance sequence gNa > gK > gCs . These biophysical attributes, together with the expression of the sodium-leak channel Nalcn transcript in CCs, state credible the contribution of NALCN. This inaugural report opens new research routes in the field of CC stimulus-secretion coupling, and extends the inventory of tissues in which NALCN is expressed to neuroendocrine glands.

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Fichiers liés : Milman et al. J Physiol 2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Philippe ColsonAnthony LevasseurPhilippe GautretFlorence FenollarVan Thuan HoangJeremy DelerceIdir BitamRachid SaileMossaab MaaloumAbdou PadaneMarielle BedottoLudivine BrechardVincent BossiMariem Ben KhedherHervé ChaudetMatthieu MillionHervé Tissot-DupontJean-Christophe LagierSouleymane MboupPierre-Edouard FournierDidier Raoult
• Organismes : Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Ecole Nationale Supérieure en Sciences de L'Aliment et des Industries Agroalimentaire Faculty of Sciences Ben M’sik Faculty of Sciences Ben M’sik Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation - Institute of Health Research, Epidemiological Surveillance and Training [Dakar, Sénégal] Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Vecteurs - Infections tropicales et méditerranéennes Centre d'épidémiologie et de santé publique des armées [Marseille] Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation - Institute of Health Research, Epidemiological Surveillance and Training [Dakar, Sénégal] Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans Travel Medicine and Infectious Disease le 25/10/2020

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Fichiers liés : S1477893921000211.pdf

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