Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Tiphaine GoulenokClaire VascoDorothée FailleNadine AjzenbergEmmanuelle de RaucourtAnnabelle DupontCorinne FrereChloé JamesElodie RabutLucia RugeriNicolas SchleinitzKarim SacréThomas PapoVirginie BarbayPierre BecarMarie Laure BigelFrançoise BoehlenLuc DarnigeEmmanuelle de RaucourtPhilippe DuboisGerard Dumas de la RoqueClaire FlaujacJean‐robert HarléChloé JamesNoémie JourdeSabrina KhelefYves LacombeMichel LangloisAurelien LebretonLéna LeflemPatrick MamouDenis MassignonRoland MeleyMarc MichelPierre MutuonFabienne Pineau VincentAntoine ReignerYohann RepesseBenoit RossignolAnne RymanNathalie TieulieMarc VasseSophie Voisin
• Organismes : Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Centre de recherche sur l'Inflammation Centre de recherche sur l'Inflammation
• Publié dans British Journal of Haematology le 29/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Roberto LorussoAlain CombesValeria Lo CocoMaria Elena de PieroJan BelohlavekThijs DelnoijIwan van der HorstDinis Reis MirandaMarcel van der LindenJ. van der HeijdenErik ScholtenNicole van Belle-van HarenWim LagrandSytse de JongDario CanduraJacinta MaasM. van den BergMaximilian MalfertheinerEsther DreierThomas MuellerUdo BoekenPayam AkhyariArtur LichtenbergDiyar SaeedHolger ThieleMatthias BaumgaertelJan SchmittoSilvia MarianiMatthias ThielmannThorsten BrennerCristoph BenkMartin CzernyJohannes KalbhennSven MaierDavid SchibilskyDawid StaudacherPhilipp HennTorje IuliuRalf MuellenbachChristian ReyherCaroline RolfesKai ZacharowskiGösta LotzMichael SonntagbauerAlexander KerstenChristian KaragiannidisSimone SchaferJulia FichteHans-Bernd HopfRobertas SamalaviciusLuca LoriniDavide GhittiLorenzo GrazioliAntonio LoforteMassimo BaiocchiErika Dal CheccoDavide PaciniPaolo MeaniAntioco CappaiClaudio Francesco RussoMaurizio BottiroliMichele MondinoMarco RanucciDario FinaAndrea BallottaAnna Mara ScandroglioAlberto ZangrilloMarina PieriPasquale NardelliEvgeny FominskiyGiovanni LandoniVito FanelliLuca BrazziGiorgia MontrucchioGabriele SalesUmberto SimonettiRosario UrbinoSergio LivigniAntonella DeganiGiuseppe RaffaMichele PilatoGennaro MartucciAntonio ArcadipaneGiovanni ChiariniNicola LatronicoSergio CattaneoCarmine PugliaGianfranco ReinaSandro SpongaUgolino LiviGiuseppe FotiMarco GianiRoberto RonaLeonello AvalliMichela BombinoMaria Cristina CostaRoberto CarozzaAbele DonatiMarco PicichèAlessandro FavaroLoris SalvadorVinicio DanziAnita ZaninIgnazio CondelloFlavio FioreMarco MoscarelliGiuseppe NassoGiuseppe SpezialeLuca SandrelliAndrea MontaltoFrancesco MusumeciAlessandro CircelliEmiliano GamberiniEmanuele RussoMarco BenniVanni AgnolettiRuggero RociolaAldo MilanoSalvatore GrassoAntonio CivitaFrancesco MurgoloEmanuele PilatoGiuseppe ComentaleAndrea MontisciFrancesco AlessandriAntonella TosiFrancesco PuglieseSimone CarelliDomenico Luca GriecoMassimo AntonelliEnrico RamoniMatteo Di NardoFrancesco MaisanoDominique BettexAlberto WeberJurg GrunenfelderJolanda ConsiglioJenni HansjoergMatthias HaenggiGianluca AgusThomas DoebleUrs ZenklusenXavier BechtoldBernard StockmanDaniel de BackerSimone GiglioliBart MeynsLeen VercaemstGreet HermanPhilippe MeerssemanChristophe VandenbrieleDieter DauweDirk VlasselaersMatthias RaesGerdy DebeuckelaereInez RodrigusPatrick BistonMichael PiagnerelliHarlinde PeperstraeteOlivier GermayKorneel VandewieleDimitri VandewegheIne WittersSven HavrinMarc BourgeoisFabio Silvio TacconeLeda NobileOlivier LheureuxAlexandre BrasseurJacques CreteurJean-Olivier DefraigneBenoît MissetRomain CourcellePhilippe TimmermansJeroen LehaenBonte FrederikJordi RieraMiguel Ángel CastroElisabet GallartMaría Martínez-MartínezEduard ArgudoMarina García-De-AciluRaul de Pablo SanchezAaron Blandino OrtizMari-Paz Fuset CabanesKarina Osorio HigaAlbert Miralles CassinaDaniel Ortiz BerbelJose Carlos Sánchez-SaladoBlasco-Lucas ArnauPablo Ruiz de GopeguiPilar RicartElena SandovalJavier VeganzonesPablo MillánPérez de la SotaPatricia Santa TeresaSara AlcantaraJorge Duerto AlvarezÁnxela Vidal GonzálezMarta LopezAntonio GordilloJosè Naranjo-IzurietaRicardo Gimeno CostaCarlos Albacete MorenoJosé Ángel de AyalaPablo Blanco-SchweizerNicolás Hidalgo AndrésVictoria BoadoJosé María Núñez MartínezVanesa Gómez CasalEsperanza Fernández GarcíaLuis Martin-VillenJoaquín Colomina ClimentLuis PintoPascal LeprinceGuillaume LebretonCharles JuvinMatthieu SchmidtMarc PinetonThierry FolliguetGabriel SaiydounPhilippe GaudardPascal ColsonJean-Francois ObadiaMatteo PozziJean Luc FellahiHodane YonisJean Christophe RichardAlessandro ParasidoJean-Philippe VerhoyeErwan FlecherLucrezia AjrhourhNicolas NesselerAlexandre MansourPierre-Grégoire GuinotJonathan ZarkaPatricia BesserveMaged MakhoulGil BolotinYigal KassifDimitros SouflerisPeter SchellongowskiNikolaos BonarosChristoph KrapfKathrin EbertPeter MairFlorian KothleutnerMariusz KowalewskySteffen ChristensenFinn Møller PedersenMartin BalíkJan BláhaMichal LipšMichal OtáhalLuigi CamporotaKathleen DalyNicola AgnewJulian BarkerLaura HeadMiguel GarciaStephane LedotVerna AquinoRebecca LewisJennifer WorthyHamza NoorIan ScottSerena O’brienIan Conrick-MartinEdmund CartonStuart GillonIan ScottLucy FlemmingLars Mikael BromanEdgars GrinsMichail KetskaloSergey TsarenkoKonstantin PopugaevSergei MininIgor KornilovAlexander SkopetsRoman KornelyukAlexandr TurchaninovVojka GorjupDaniil ShelukhinYoussef El DsoukiMurat SarginMehmet Ali KayginShestakova LianaSeverin PussGro SoerensenRosén MagnusMikael KanetoftPia WatsonBengt RedforsNiklas KrennerM. Velia AntoniniNicholas BarrettMirko BelliatoMark DavidsonMatteo Di NardoSimon FinneyJo-Anne FowlesMaximilian HalbeFelix HennigTim JonesThomas MuellerLuis PintoJonathan SmithJordi RieraPeter RoeleveldJustyna SwolLeen Vercaemst
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Intensive Care Medicine le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Jean BousquetJosep AntoWienczyslawa CzarlewskiTari HaahtelaSusana FonsecaGuido IaccarinoHubert BlainAlain VidalAziz SheikhCezmi A AkdisTorsten ZuberbierAmir Hamzah Abdul LatiffBaharudin AbdullahWerner AbererNancy AbusadaIan M AdcockAlejandro AfaniIoana AgacheXenofon AggelidisJenifer AgustinMübeccel AkdisMona Al‐ahmadAbou Al‐zahab BassamHussam AlburdanOscar Aldrey‐palaciosEmilio Alvarez CuestaHiba Alwan SalmanAshraf AlzaabiSalma AmadeGene AmbrocioRosana AnglesIsabella Annesi‐maesanoIgnacio Javier Ansotegui-ZubeldiaPaula Ara BardajoStefania ArasiHasan ArshadMaria Cristina ArtesaniEstrella AsayagFrancesca AvolioKhuzama AzhariClaus BachertDiego BagnascoIlaria BaiardiniNissera BajrovićPetros BakakosSergio Bakeyala MongonoChristine Balotro‐torresSergio BarbaCristina BarbaraElsa BarbosaBruno BarretoJoan BartraEric BatemanLkhagvaa BatturAnna BedbrookMartín Bedolla BarajasBianca BeghéAntra BekereElizabeth BelAli Ben KhederMikael BensonEmilia Camelia BergheaKarl‐christian BergmannRoberto BernardiniDavid BernsteinMike BewickSlawomir BialekArtur BiałoszewskiThomas BieberNils BilloMaria Beatrice BiloCarsten Bindslev‐jensenLeif BjermerIrina BoboleaMalgorzata Bochenska MarciniakChristine BondAttilio BonerMatteo BoniniSergio BoniniSinthia Bosnic‐anticevichIsabelle BosseSofia BotskariovaJacques BouchardLouis‐philippe BouletRodolphe BourretPhilippe BousquetFulvio BraidoAndrew BriggsChristopher BrightlingJan BrozekLuisa BrussinoRoland BuhlRoxana BumbaceaRosalva BuquicchioMaría‐teresa Burguete CabañasAndrew BushWilliam BusseJeroen ButersFernan Caballero‐fonsecaMoïses CalderonMario CalvoPaulo CamargosThierry CamuzatF.R. CanevariAntonio CanoG Walter CanonicaArnaldo Capriles‐hulettLuis CaraballoVicky CardonaKai‐hakon CarlsenJonas Carmon PirezJorge CaroWarner CarrPedro Carreiro‐martinsFredelita Carreon‐asuncionAna‐maria CarriazoT. Bruce CasaleMary‐ann CastorElizabeth CastroA.G. CavigliaLorenzo CecchiAlfonso Cepeda SarabiaRamanathan ChandrasekharanYoon‐seok ChangVictoria Chato‐andezaLida ChatziChristina ChatzidakiNiels ChavannesClaudia Chaves LoureiroMarta ChelninskaYuzhi ChenLei ChengSharon ChinthrajahTomás ChivatoEkaterine ChkhartishviliGeorge ChristoffHenry ChrystynDerek ChuAntonio ChuaAlexander ChuchalinKian Fan ChungAlberto CiceránCemal CingiGiorgio CiprandiIeva CiruleAna Carla CoelhoEnrico CompalatiJannis ConstantinidisJaime Correia de SousaElisio Manuel CostaDavid J. CostaMaría del Carmen Costa DomínguezAndré CosteM. CottiniLinda CoxCarlos CrisciMaria Angiola CrivellaroAlvaro A. CruzJohn CullenAdnan CustovicBiljana CvetkovskiGennaro d'AmatoJane SilvaRonald DahlSven‐erik DahlenVasilis DaniilidisLouei DarjazininahhasUlf DarsowJanet DaviesFrédéric BlayGiulia de FeoEloisa de GuiaChato Los SantosEsteban de Manuel KeenoyGovert de VriesDiana DeleanuPascal DemolyJudah DenburgPhilippe DevillierAlain DidierSanja Dimic JanjicMaria DimouAnh Tuan Dinh‐xuanRatko DjukanovicMaria Do Ceu TexeiraDejan DokicMargarita Gabriela Dominguez SilvaHabib DouaguiNikolaos DouladirisMaria DoulaptsiGérard DrayRuta DubakieneEve DupasStephen DurhamMarzia DuseMark DykewiczDidier EboNatalija EdelbaherThomas EiweggerPatrik EklundYehia El‐gamalZeinab El‐sayedShereen El‐sayedMagda El‐seifyRegina EmuzyteLourdes EnecillaMarina ErholaHeidilita EspinozaJesús Guillermo Espinoza ContrerasJohn FarrellLenora FernandezAntje Fink WagnerAlessandro Giovanni FiocchiWytske J. FokkensFolletti LeniaJoão Almeida FonsecaJean‐françois FontaineFrancesco ForastiereJose Miguel Fuentes PèrezEmily Gaerlan–resureccionMina GagaJosé Luis Gálvez RomeroAmiran GamkrelidzeAlexis GarciaCecilia Yvonne García CobasMaría de La Luz Hortensia García CruzJacques GayraudMatteo GelardiBilun GemiciogluDimitra GennimataSonya GenovaJosé GeredaRoy Gerth van WijkAntonio GiulianoMaximiliano GomezSandra González DiazMaia GotuaChristos GrigoreasIneta GrisleLeo GualteiroMarta GuidacciNick GuldemondZdenek GutterAntonieta GuzmánRamsa HalloumDavid HalpinEckard HamelmannSuleiman HammadiRichard HarveyEnrico HefflerJoachim HeinrichAdnan HejjaouiBirthe Hellquist‐dahlLuiana Hernández VelázquezMark HewElham HossnyPeter HowarthMartin HrubiškoYunuen Rocío Huerta VillalobosGiovanna MarazziHusain SalinaMichael HylandMoustafa IbrahimNataliya IlinaMaddalena IllarioCristoforo IncorvaiaAntonio InfantinoCarla IraniZhanat IspayevaJuan‐carlos IvancevichEdgardo E.J. JaresDeborah JarvisEwa JassemKlemen JenkoRubén Darío Jiméneracruz UscangaSebastian JohnstonGuy JoosMaja JoštKaja JulgeKi‐suck JungJocelyne JustMarek JutelIgor KaidashevOmer KalayciFuat KalyoncuJeni KapsaliPrzemyslaw KardasJussi KarjalainenCarmela KasalaMichael KatotomichelakisLoreta KavaliukaiteBennoor KaziThomas KeilPaul KeithMusa KhaitovNikolai KhaltaevYou‐Young KimBruce KirengaJorg Kleine‐tebbeLudger KlimekBernard Koffi N’goranEvangelia KompotiPeter KopačGerard KoppelmanAnja KorenjevericaSeppo KoskinenMitja KošnikKosta KostovMarek KowalskiTanya KralimarkovaKarmen Kramer VrščajHelga KraxnerSamo KreftVicky KritikosDmitry KudlayMikael KuitunenInger KullP. KunaMaciej KupczykVioleta KvedarieneMarialena KyriakakouNika LalekMassimo LandiStephen LaneDésiree Larenas‐linnemannSusanne LauDaniel LauneJorge LavrutLan LeMartina LenzenhuberMarcus LessaMichael LevinJing LiPhilip LiebermanGiuseppe LiottaBrian LipworthXuandao LiuRommel LoboKarin Lodrup CarlsenCarlo LombardiRenaud LouisStelios LoukidisOlga M. LourençoJorge Luna PechBojan MadjarEnrico MaggiAntoine MagnanBassam MahboubAlpana MairYassin MaisAnke‐hilse Maitland van Der ZeeMika MakelaMichael MakrisHans‐jorgen MallingMariana MandajievaPatrick ManningManolis ManousakisPavlos MaragoudakisGianluigi MarsegliaGailen MarshallMohammad Reza MasjediJorge MásperoJuan José Matta CamposMarcus MaurerSandra Mavale‐manuelCem MeçoErik MelénGiovanni MelioliElisabete Melo‐gomesEli MeltzerEnrica MendittoAndrew Menzies‐gowHans MerkJean‐pierre MichelYann MicheliNeven MiculinicLuís MidãoFlorin MihaltanNikolaos MikosManlio MilaneseBranislava MilenkovicDimitrios MitsiasBassem MoallaGiuliana ModaMaría Dolores Mogica MartínezYousser MohammadMostafa MoinMathieu MolimardIsabelle MomasMonique MommersAlessandro MonacoSteve MontefortDory MoraMário Morais‐almeidaRalph MösgesBadreldin MostafaJ. MullolLars MünterAntonella MuraroRuth MurrayAntonio MusarraTihomir MustakovRobert NaclerioKari C NadeauNadif RAlla NakonechnaLeyla Namazova‐baranovaGretchen Navarro‐locsinHugo NeffenKristof NekamAngelos NeouEustachio NettisDaniel NeubergerLaurent NicodStefania NicolaVerena Niederberger‐leppinMarek NiedoszytkoAntonio NietoEttore NovellinoElizabete NunesDieudonné NyembueRobyn E. O’hehirCvetanka OdjakovaKen OhtaYoshitaka OkamotoKimi OkuboBrian OliverGabrielle OnoratoMaria Pia OrruSolange OuédraogoKampadilemba OuobaPier Luigi PaggiaroAris PagkalosGiovanni PajnoGianni PalaS.P. PalaniappanIsabella Pali‐schöllSusanna PalkonenStephen PalmerCarmen Panaitescu BunuPetr PanznerNikolaos G. PapadopoulosVasilis PapanikolaouAlberto PapiBojidar ParalchevGiannis ParaskevopoulosHae‐sim ParkGiovanni PassalacquaVincenzo PatellaIan PavordRuby PawankarSoren PedersenSusete PeleveSimona PelleginoAna PereiraTamara PérezAndrea PernaDiego PeroniOliver PfaarNhân Pham‐thiBernard PigeariasIsabelle PinKonstantina PiskouConstantinos PitsiosDavor PlavecDagmar PoethigWolfgang PohlAntonija Poplas SusicTodor PopovFabienne PortejoiePaul PotterLars PoulsenAlexandra Prados‐torresFotis PrarrosDavid PriceEmmanuel ProkopakisFrancesca PuggioniElisa Puig‐domenechRobert PuyKlaus RabeFilip RaciborskiJosephine RamosMarysia RectoShereen RedaFrederico RegateiroNorbert ReiderSietze ReitsmaSusana Repka‐ramirezErminia RidoloJanet RimmerDaniela Rivero YeverinoJosé Angelo RizzoCarlos Robalo‐cordeiroGraham RobertsNicolas RocheMónica Rodríguez GonzálezEréndira Rodríguez ZagalGiovanni RollaChristine RollandRegina Roller‐wirnsbergerMiguel Roman RodriguezAntonino RomanoJan RomantowskiPhilippe RombauxJoel RomualdezJose Rosado‐pintoNelson RosarioLanny RosenwasserOliviero RossiMenachem RottemPhilip W. RouadiNikoleta RovinaIrma Rozman SinurMauricio RuizLucy Tania Ruiz SeguraDermot RyanHironori SagaraDaiki SakaiDaiju SakuraiWafaa SalehJohanna SalimakiKonstantinos SamitasBoleslaw SamolinskiMaría Guadalupe Sánchez CoronelMario Sanchez‐borgesJaime Sanchez‐lopezCodrut SarafoleanuFaradiba Sarquis SerpaJoaquin Sastre‐dominguezEleonora SaviBisher SawafGlenis ScaddingSophie ScheirePeter Schmid‐grendelmeierJuan Francisco SchuhlHolger SchunemannMaria SchvalbováJorgen SchwarzeNicola ScichiloneGianenrico SennaCecilia SepúlvedaElie SerranoMike ShieldsVasil ShishkovNikos SiafakasAlexander SimeonovEstelle Fer SimonsJuan Carlos SisulBrigita SitkauskieneIngelbjorg SkrindoTanja SokličkošakDirceu SoléTalant SooronbaevManuel Soto‐martinezManuel Soto‐quirosBarnaro Sousa PintoMilan SovaMichael SoykaKrzysztof SpecjalskiOtto SprangerSofia StamatakiLina StefanakiCristiana StellatoRafael StelmachTimo StrandbergPetra StuteAbirami SubramaniamCharlotte Suppli UlrikMichael SutherlandSilvia SylvestreAikaterini SyrigouLuis Taborda BarataNadejda TakovskaRachel TanFrances TanVincent TanIng Ping TangMasami TaniguchiLine TannertPongsakorn TantilipikornJessica TattersallFilippo TesiCarel ThijsMike ThomasTeresa ToAna‐maria Todo‐bomAlkis TogiasPeter‐valentin TomazicVesna Tomic‐spiricSanna Katriina Toppila-SalmiElina ToskalaMassimo TriggianiNadja TrillerKatja TrillerIoanna TsiligianniM. UbertiRuxandra UlmeanuJure UrbancicMarilyn Urrutia PereiraMartina VachovaFelipe ValdésRudolf ValentaMarylin Valentin RostanAntonio ValeroArunas ValiulisMina VallianatouErkka ValovirtaMichiel van EerdEric van GanseMarianne HageOlivier VandenplasTuula VasankariDafina VassilevaCesar Velasco MunozMaria Teresa VenturaCécilia Vera‐munozDilyana VichevaPakit VichyanondPetra VidgrenGiovanni ViegiClaus VogelmeierLeena von HertzenTheodoros VontetsianosDimitris VourdasVu Tran Thien QuanMartin WagenmannSamantha WalkerDana WallaceD. WangSusan WasermanMagnus WickmanSian WilliamsDennis WilliamsNicola WilsonGary WongKent WooJohn WrightPiotr WroczynskiParaskevi XepapadakiPlamen YakovlievMasao YamaguchiKwok YanYoke Yeow YapBarbara YawnPanayiotis YiallourosArzu YorganciogluShigemi YoshiharaIan YoungOsman YusufAsghar ZaidiFares ZaitounHeather ZarM.T. ZeddaMario ZernottiLuo ZhangNanshan ZhongMihaela ZidarnCelia Zubrinich
• Organismes : Charité - UniversitätsMedizin = Berlin University Medicine Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Berlin Institute of Health Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon Centre Hospitalier Régional Universitaire [Montpellier] Instituto de Salud Global - Institute For Global Health [Barcelona] IMIM-Hospital del Mar Universitat Pompeu Fabra [Barcelona] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health Helsinki University Hospital [Finland] Universidade do Porto = University of Porto University of Naples Federico II = Università degli studi di Napoli Federico II Centre Hospitalier Régional Universitaire [Montpellier] EuroMov - Digital Health in Motion AgroParisTech Usher Institute of Population Health Sciences and Informatics [Edinburgh, U.K.] Universität Zürich [Zürich] = University of Zurich Charité - UniversitätsMedizin = Berlin University Medicine Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Berlin Institute of Health Institut Desbrest d'Epidémiologie et de Santé Publique EuroMov - Digital Health in Motion
• Publié dans Allergy le 26/10/2020

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Résumé : Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1 R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1 R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.

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Fichiers liés : bousquet-all-cabb.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Laura Grau-MercierAdrien ChetiouiLaurent MullerClaire RogerRomain Genre GrandpierreJean Emmanuel de La CoussayePhilippe CuvillonPierre-Géraud ClaretXavier BobbiaLaura Grau‐mercierJean Emmanuel CoussayePierre‐géraud Claret
• Organismes : Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Centre Hospitalier Régional Universitaire [Montpellier] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes] Unité de réanimation médicale [CHU de Carémeau, Nîmes]
• Publié dans Journal of Clinical Ultrasound le 01/11/2020

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Résumé : Ultrasound-guidance of radial artery catheter insertion improves the first attempt success and reduces the occurrence of hematomas. Needle-tracking devices optimize needle-ultrasound beam alignment by displaying in real-time the needle tip position. We compared the median time need by experienced physicians to achieve radial artery puncture using either a conventional ultrasonography device (CUD) or a magnetic needle-tracking ultrasound device (MUD) in a simulation training arm model. Methods: Fifty experienced residents and physicians performed two punctures in randomized order with the CUD and the MUD. The primary outcome was puncture duration; the secondary outcomes were puncture success, rate of accidental vein puncture, and practitioner's comfort (subjective scale 0-10). Results: The median [lower-upper quartile] puncture time was 10 [6-14] seconds when using CUD and 4 [3-7] seconds when using MUD (P < .01). In the multivariate analysis, MUD use was associated with decreased puncture duration whatever the puncture order (OR 1.13 [1.07-1.20], P < .01). The participants performed 99 (99%) successful punctures: 50 with the MUD (100%) and 49 with the CUD (98%). There was no accidental venous puncture. The practitioner's comfort level was 6.5 [6, 7] with the CUD and 8 [7-9] with the MUD (P < .01). Conclusion: MUD reduced radial artery puncture time and improved physician comfort in a simulation training arm model.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : George NtaiosMenno HuismanHans-Christoph DienerJonathan HalperinChristine TeutschSabrina MarlerVenkatesh GurusamyMilla ThompsonDavid FitzmauriceBrian OlshanskyDavid FitzmauriceDzifa Wosornu AbbanNasser AbdulAtilio Marcelo AbudFran AdamsSrinivas AddalaPedro AdragãoWalter AgenoRajesh AggarwalSergio AgostiPiergiuseppe AgostoniFrancisco AguilarJulio Aguilar LinaresLuis AguinagaJameel AhmedAllessandro AielloPaul AinsworthJorge Roberto AiubRaed Al-DallowLisa AldersonJorge Antonio Aldrete VelascoDimitrios AlexopoulosFernando Alfonso ManterolaPareed AliyarDavid AlonsoFernando Augusto Alves da CostaJosé AmadoWalid AmaraMathieu AmelotNima AmjadiFabrizio AmmiratiMarianna AndradeNabil AndrawisGiorgio AnnoniGerardo AnsaloneM.Kevin ArianiJuan Carlos AriasSébastien ArmeroChander AroraMuhammad Shakil AslamM. AsselmanPhilippe AudouinCharles AugenbraunS. AydinIvaneta AyryanovaEmad AzizLuciano Marcelo BackesE. BadingsErmentina BagniSeth BakerRichard BalaAntonio BaldiShigenobu BandoSubhash BanerjeeAlan BankGonzalo Barón EsquiviasCraig BarrMaria BartlettVanja Basic KesGiovanni BaulaSteffen BehrensAlan BellRaffaella BenedettiJuan Benezet MazuecosBouziane BenhalimaJutta Bergler-KleinJean-Baptiste BerneauRichard BernsteinPercy BerrospiSergio BertiAndrea BerzElizabeth BestPaulo BettencourtRobert BetzuRavi BhagwatLuna BhattaFrancesco BiscioneGiovanni BisignaniToby BlackMichael BlochStephen BloomEdwin BlumbergMario BoEllen BøhmerAndreas BollmannMaria Grazia BongiorniGiuseppe BorianiD.J. BoswijkJochen BottEdo BottacchiMarica Bracic KalanDrew BradmanDonald BrautigamNicolas BretonP.J.A.M. BrouwersKevin BrowneJordi Bruguera CortadaA. BruniClaude BrunschwigHervé BuathierAurélie BuhlJohn BullingaJose Walter CabreraAlberto CaccavoShanglang CaiSarah CaineLeonardo CalòValeria CalviMauricio Camarillo SánchezRui CandeiasVincenzo CapuanoAlessandro CapucciRonald CaputoTatiana Cárdenas RizoFrancisco CardonaFrancisco Carlos da Costa DarrieuxYan Carlos Duarte VeraAntonio CaroleiSusana CarreñoPaula CarvalhoSusanna CaryGavino CasuClaudio CavalliniGuillaume CaylaAldo CelentanoTae-Joon ChaKwang Soo ChaJei Keon ChaeKathrine ChalamidasKrishnan ChallappaSunil Prakash ChandHarinath ChandrashekarLudovic ChartierKausik ChatterjeeCarlos Antero Chavez AyalaAamir CheemaAmjad CheemaLin ChenShih-Ann ChenJyh Hong ChenFu-Tien ChiangFrancesco ChiarellaLin Chih-ChanYong Keun ChoJong-Il ChoiDong Ju ChoiGuy ChouinardDanny Hoi-Fan ChowDimitrios ChrysosGalina ChumakovaEduardo Julián José Roberto Chuquiure ValenzuelaNicoleta Cindea NicaDavid CislowskiAnthony ClayPiers CliffordAndrew CohenMichael CohenSerge CohenFurio ColivicchiRonan CollinsPaolo ColonnaSteve ComptonDerek ConnollyAlberto ContiGabriel Contreras BuenostroGregg CoodleyMartin CooperJulian CoronelGiovanni CorsoJuan Cosín SalesYves CottinJohn CovaleskyAurel CracanFilippo CreaPeter CreanJames CrenshawTina CullenHarald DariusPatrick DaryOlivier DascotteIra DauberVicente DavalosRuth DaviesGershan DavisJean-Marc DavyMark DayerMarzia de BiasioSilvana de BonisRaffaele de CaterinaTeresiano de FranceschiJ.R. de GrootJosé de HortaAxel de La BriolleGilberto de La Pena TopeteAngelo Amato Vicenzo de PaolaWeimar de SouzaA. de VeerLuc de WolfEric DecoulxSasalu DeepakPascal DefayeFreddy Del-Carpio MunozDiana Delic BrkljacicN. Joseph DeumiteSilvia Di LeggeIgor DiembergerDenise DietzPedro DionísioQiang DongFabio Rossi dos SantosElena DotchevaRami DoukkyAnthony d'SouzaSimon DubreyXavier DucrocqDmitry DupljakovMauricio DuqueDipankar DuttaNathalie DuvillaA. DuygunRainer DziewasCharles EatonWilliam EavesL.A. Ebels-TuinbeekClifford EhrlichSabine Eichinger-HasenauerSteven EisenbergAdnan El JabaliMahfouz El ShahawyMauro Esteves HernandesAna Etxeberria IzalRudolph EvonichOksana EvseevaAndrey EzhovRaed FahmyQuan FangRamin FarsadLaurent FauchierStefano FavaleMaxime FayardJose Luis FedeleFrancesco FedeleOlga FedorishinaSteven FeraLuis Gustavo Gomes FerreiraJorge FerreiraClaudio FerriAnna FerrierHugo FerroAlexandra FinsenBrian FirstStuart FischerCatarina FonsecaLuísa Fonseca AlmeidaSteven FormanBrad FrandsenWilliam FrenchKeith FriedmanAthena FrieseAna Gabriela FruntelataShigeru FujiiStefano FumagalliMarta FundamenskiYutaka FurukawaMatthias GabelmannNashwa GabraNiels GadsbøllMichel GalinierAnders GammelgaardPriya GaneshkumarChristopher GansAntonio Garcia QuintanaOlivier GartenlaubAchille GaspardoneConrad GenzFrédéric GeorgerJean-Louis GeorgesSteven GeorgesonEvaldas GiedrimasMariusz GierbaIgnacio Gil OrtegaEve GillespieAlberto GinigerMichael GiudiciAlexandros GkotsisTaya GlotzerJoachim GmehlingJacek GniotPeter GoethalsSeth GoldbargRonald GoldbergBritta GoldmannSergey GolitsynSilvia GómezJuan Gomez MesaVicente Bertomeu GonzalezJesus Antonio Gonzalez HermosilloVíctor Manuel González LópezHervé GorkaCharles GornickDiana GorogVenkat GottipatyPascal GoubeIoannis GoudevenosBrett GrahamG. Stephen GreerUwe GremmlerPaul GrenaMartin GrondEdoardo GrondaGerian GrönefeldXiang GuIvett Guadalupe Torres TorresGabriele GuardigliCarolina GuevaraAlexandre GuignierMichele GuliziaMichael GumbleyAlbrecht GüntherAndrew HaGeorgios HahalisJoseph HakasChristian HallBing HanSeongwook HanJoe HargroveDavid HargrovesKenneth HarrisTetsuya HarunaEmil HayekJeff HealeySteven HearneMichael HeffernanGeir HeggelundJ.A. HeijmeriksMaarten HemelsI. HendriksSam HeneinSung-Ho HerPaul HermanyJorge Eduardo Hernández del RíoYorihiko HigashinoMichael HillTetsuo HisadomeEiji HishidaEtienne HofferMatthew HoghtonKui HongSuk Keun HongStevie HorbachMasataka HoriuchiYinglong HouJeff HsingChi-Hung HuangDavid HuckinsKathy HughesA. HuizingaE.L. HulsmanKuo-Chun HungGyo-Seung HwangMargaret IkpohDavide ImbertiHüseyin InceCiro IndolfiShujiro InoueDidier IrlesHarukazu IsekiC. Noah IsraelBruce IteldVenkat IyerEwart Jackson-VoyzeyNaseem JaffraniFrank JägerMartin JamesSung-Won JangNicolas JaramilloNabil JarmukliRobert JeanfreauRonald JenkinsCarlos Jerjes SánchezJavier JimenezRobert JobeTomas Joen-JakobsenNicholas JonesJose Carlos Moura JorgeBernard JouveByung Chun JungKyung Tae JungWerner JungMikhail KachkovskiyKrystallenia KafkalaLarisa KalininaBernd KallmünzerFarzan KamaliTakehiro KamoPriit KampusHisham KashouAndreas KastrupApostolos KatsivasElizabeth KaufmanKazuya KawaiKenji KawajiriJohn KazmierskiP. KeelingJosé Francisco Kerr SaraivaGalina KetovaAjit Singh KhairaAleksey KhripunDoo-Il KimYoung Hoon KimNam Ho KimDae Kyeong KimJeong Su KimJune Soo KimKi Seok KimJin Bae KimElena KinovaAlexander KleinJames KmetzoG. Larsen KnellerAleksandar KnezevicSu Mei Angela KohShunichi KoideAnastasios KolliasJ.A. KooistraJay KoonsMartin KoschutnikWilliam KostisDragan KovacicJacek KowalczykNatalya KoziolovaPeter P. KraftJohannes KragtenMori KrantzLars KrauseB.J. KrenningF. KrikkeZ. KromhoutWaldemar KrysiakPriya KumarThomas KümlerMalte KunissJen-Yuan KuoAchim KüppersKarla KurrelmeyerChoong Hwan KwakBénédicte LaboulleArthur LabovitzWen Ter LaiAndy LamYat Yin LamFernando Lanas ZanettiCharles LandauGiancarlo LandiniEstêvão Lanna FigueiredoTorben LarsenKarine LavandierJessica LeblancMoon Hyoung LeeChang-Hoon LeeJohn LehmanAna LeitãoNicolas LelloucheMalgorzata LelonekRadoslaw LenarczykT. LenderinkSalvador León GonzálezPeter Leong-SitMatthias LeschkeNicolas LeyZhanquan LiXiaodong LiWeihua LiXiaoming LiChristhoh LichyIra LieberRamon Horacio Limon RodriguezHailong LinFeng LiuHengliang LiuGuillermo Llamas EsperonNassip Llerena NavarroEric LoSergiy LokshynAmador LópezJosé Luís López-SendónAdalberto Menezes Lorga FilhoRichard LorraineCarlos Alberto LuengasRobert LukeMing LuoSteven LupovitchPhilippe LyrerChangsheng MaGenshan MaIrene MadariagaKoji MaenoDominique MagninGustavo MaidSumeet MainigiKonstantinos MakaritsisRohit MalhotraRickey ManningAthanasios ManolisHelard Andres Manrique HurtadoIoannis MantasFernando Manzur JattinVicky MaquedaNiccolo MarchionniFrancisco Marin OrtunoAntonio Martín SantanaJorge MartinezPetra MaskovaNorberto Matadamas HernandezKatsuhiro MatsudaTillmann MaurerCiro MauroErik MayNolan MayerJohn McclureTerry MccormackWilliam McgarityHugh McintyreBrent MclaurinFeliz Alvaro Medina PalominoFrancesco MelandriHiroshi MenoDhananjai MenziesMarco MercaderChristian MeyerBeat MeyerJacek MiarkaFrank MibachDominik MichalskiPatrik MichelRami Mihail ChreihGhiath MikdadiMilan MikusDavor MilicicConstantin MilitaruSedi MinaieBogdan MinescuIveta MintaleTristan MiraultMichael MirroDinesh MistryNicoleta Violeta MiuNaomasa MiyamotoTiziano MoccettiAkber MohammedAzlisham Mohd NorMichael MollerusGiulio MolonSergio MondilloPatrícia MonizLluis MontVicente MontagudOscar MontañaCristina MontiLuciano MorettiKiyoo MoriAndrew MoriartyJacek MorkaLuigi MoschiniNikitas MoschosAndreas MüggeThomas MulhearnCarmen MuresanMichela MuriagoWlodzimierz MusialCarl MusserFrancesco MusumeciThuraia NagehHidemitsu NakagawaYuichiro NakamuraToru NakayamaGi-Byoung NamMichele NannaIndira NatarajanHemal NayakStefan NaydenovJurica NazliAlexandru Cristian NechitaLibor NechvatalSandra Adela NegronJames NeimanFernando Carvalho NeuenschwanderDavid NevesAnna NeykovaRicardo Nicolás MiguelGeorge NijmehAlexey NizovRodrigo Noronha CamposJanko NossanTatiana NovikovaEwa Nowalany-KozielskaEmmanuel NsahJuan Carlos Nunez FragosoSvetlana NurgalievaDieter NuyensOle NyvadManuel Odin de Los Rios IbarraPhilip O'DonnellMartin O'DonnellSeil OhYong Seog OhDongjin OhGilles O'HaraKostas OikonomouClaudia OlivaresRichard OliverRafael Olvera RuizChristoforos OlympiosAnna Omaszuk-KazberukJoaquín Osca AsensiEena Padayattil JoseFrancisco Gerardo Padilla PadillaVictoria Padilla RiosGiuseppe PajesA. Shekhar PandeyGaetano PaparellaF. ParisHyung Wook ParkJong Sung ParkFragkiskos ParthenakisEnrico PassamontiRajesh PatelJaydutt PatelMehool PatelJanice PatrickRicardo Pavón JimenezAnalía PazVittorio PengoWilliam PentzBeatriz PérezAlma Minerva Pérez RíosAlejandro Pérez-CabezasRichard PerlmanViktor PersicFrancesco PerticoneTerri PetersSanjiv PetkarLuis Felipe PezoChristian PflückeDavid PhamRoland PhillipsStephen PhlaumDenis PietersJulien PineauArnold PinterFausto PintoR. PistersNediljko PivacDarko PocanicCristian PodoleanuAlessandro PolitanoZdravka PoljakovicStewart PollockJose Polo GarcéaHolger PoppertMaurizio PorcuAntonio Pose ReinoNeeraj PrasadDalton Bertolim PrécomaAlessandro PrelleJohn ProdafikasKonstantin ProtassovMaurice PyeZhaohui QiuJean-Michel QuedillacDimitar RaevCarlos Antonio Raffo GradoSidiqullah RahimiArturo RaisaroBhola RamaRicardo RamosMaria RanieriNuno RaposoEric RashbaUrsula Rauch-KroehnertRamakota ReddyGiulia RendaShabbir RezaLuigi RiaDimitrios RichterHans RickliWerner RiekerTomas Ripolil VeraLuiz Eduardo RittDouglas RobertsIgnacio Rodriguez BrionesAldo Edwin Rodriguez EscuderoCarlos Rodríguez PascualMark RomanFrancesco RomeoE. RonnerJean-Francois RouxNadezda RozkovaMiroslav RubacekFrank RubalcavaAndrea RussoMatthieu Pierre RutgersKarin RybakSamir SaidTamotsu SakamotoAbraham SalacataAdrien SalemRafael Salguero BodesMarco SaltzmanAlessandro SalvioniGregorio Sanchez VallejoMarcelo Sanmartín FernándezWladmir Faustino SaporitoKesari SarikondaTaishi SasaokaHamdi SatiIrina SavelievaPierre-Jean ScalaPeter SchellingerCarlos ScherrLisa SchmitzKarl-Heinz SchmitzBettina SchmitzTeresa SchnabelSteffen SchnuppPeter SchoenigerNorbert SchönPeter SchwimmbeckClare SeamarkGreg SearlesKarl-Heinz SeidlBarry SeidmanJaroslaw SekLakshmanan SekaranCarlo SerratiNeerav ShahVinay ShahAnil ShahShujahat ShahVijay Kumar SharmaLouise ShawKhalid SheikhNaruhito ShimizuHideki ShimomuraDong-Gu ShinEun-Seok ShinJunya ShiteGerolamo SibilioFrank SilverIveta SimeTim SimmersNarendra SinghPeter SiostrzonekDidier SmadjaDavid SmithMarcelo SnitmanDario Sobral FilhoHassan SodaCarl SofleyAdam SokalYannie Soo Oi YanRodolfo SotolongoOlga Ferreira de SouzaJon Arne SparbyJindrich SpinarDavid SprigingsAlex SpyropoulosDimitrios StakosClemens SteinwenderGeorge StergiouIan StiellMarcus StoddardAnastas StoikovWitold StrebIoannis StyliadisGuohai SuXi SuWanda SudnikKai SuklesXiaofei SunH. SwartJanko Szavits-NossanJens TaggeselleYuichiro TakagiAmrit Pal Singh TakharAngelika TammKatsumi TanakaTanyanan TanawuttiwatSherman TangAylmer TangGiovanni TarsiTiziana TassinariAshis TayalMuzahir TayebjeeJ.M. Ten BergDan TesloianuSalem H.K. TheDierk ThomasSerge TimsitTetsuya TobaruAndrzej TomasikMikhail TorosoffEmmanuel TouzeElina TrendafilovaW. Kevin TsaiHung Fat TseHiroshi TsutsuiTian Ming TuYpe TuiningaMinang TurakhiaSamir TurkWayne TcurnerArnljot TveitRichard TytusC. ValadãoP.F.M.M. van BergenPhilippe van de BorneB.J. van den BergC. van Der ZwaanM. van EckPeter VanackerDimo VasilevVasileios VasilikosMaxim VasilyevSrikar VeerareddyMario Vega MiñoAsok VenkataramanPaolo VerdecchiaFrancesco VersaciErnst Günter VesterHubert VialJason VictoryAlejandro VillamilMarc VincentAnthony VlastarisJürgen Vom DahlKishor VoraRobert VranianPaul WakefieldNingfu WangMingsheng WangXinhua WangIacopo VivarelliTian WangAlberta WarnerKouki WatanabeJeanne WeiChristian WeimarStanislav WeinerRenate WeinrichMing-Shien WenMarcus WiemerPreben WiggersAndreas WilkeDavid WilliamsMarcus WilliamsBernhard WitzenbichlerBrian WongKa Sing Lawrence WongBeata Wozakowska-KaplonShulin WuRichard WuSilke WunderlichNell WyattJohn (jack) WylieTaslima AnwarXiangdong XuHiroki YamanoueTakeshi YamashitaPing Yen Bryan YanTianlun YangJing YaoKuo-Ho YehWei Hsian YinYoto YotovRalf Zahn
• Organismes : Leiden University Medical Center [Leiden] Universität Duisburg-Essen = University of Duisburg-Essen [Essen] Icahn School of Medicine at Mount Sinai [New York] University of Liverpool University of Iowa [Iowa City]
• Publié dans The Hellenic Journal of Cardiology le 30/10/2020

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Résumé : Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Aurélien DinhJacques RopersClara DuranBenjamin DavidoLaurène DeconinckMorgan MattOlivia SenardAurore LagrangeSabrina MakhloufiGuillaume MellonVictoire de LastoursFrédérique BouchandEmmanuel MathieuJean-Emmanuel KahnElisabeth RouveixJulie GrenetJennifer DumoulinThierry ChinetMarion PépinVéronique DelceySylvain DiamantisDaniel BenhamouVirginie VitratMarie-Christine DombretBertrand RenaudChristian PerronneYann-Eric ClaessensJosé LabarèreJean-Pierre BedosPhilippe AegerterAnne-Claude Crémieux
• Organismes : Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Centre Hospitalier Universitaire [CHU Grenoble]
• Publié dans The Lancet le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : Antoine YrondiGuillaume VaivaMichel WalterThierry A. d'AmatoFrank BellivierDjamila BennabiThierry BougerolVincent CamusOlivier DoumyJean-Baptiste GentyEmmanuel HaffenJérôme HoltzmannMathilde HornChristophe LançonMarion LeboyerPierre-Michel LlorcaJulia MaruaniRémi MoirandFanny MolièreJean PetrucciRaphaelle RichieriLudovic SamalinL. SchmittFlorian StephanPhilippe CourtetWissam El-HageBruno AouizerateV. BarteauS. BensalemH. LaouamriKarmene SouryisL. MalletL. YonD. PierreM. SarrailI. RyffE. BeuchetG. TioC. CappeE. ClercM. GarnierR.M. HonciucE. AllauzeO. BlancN. AllailiI. NietoJ. MeheustY. SunthavyM. PolosanP. CourvoisierB. FredembachS. Foubert-AndreaniFrédéric HaesebaertC. DubienM. LefebvreA. MeznadJérôme BrunelinP. PeriM. FaugereC. Faget-AgiusJ.P. BoulengerC. Mesmeur
• Organismes : Fondation FondaMental [Créteil] Centre Hospitalier Universitaire de Toulouse Toulouse NeuroImaging Center Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [CHU Lille] Fondation FondaMental [Créteil] Hopital de Bohars - CHRU Brest Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Fondation FondaMental [Créteil] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Fondation FondaMental [Créteil] Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire [CHU Grenoble] Fondation FondaMental [Créteil] Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire [CHU Grenoble] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [CHU Lille] Fondation FondaMental [Créteil] Hôpital de la Conception [CHU - APHM] Fondation FondaMental [Créteil] CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil] CHU Clermont-Ferrand Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux Fondation FondaMental [Créteil] Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Neuropsychiatrie : recherche épidémiologique et clinique Fondation FondaMental [Créteil] CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil] Hôpital de la Conception [CHU - APHM] Fondation FondaMental [Créteil] CHU Clermont-Ferrand Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux Fondation FondaMental [Créteil] Centre Hospitalier Universitaire de Toulouse Toulouse NeuroImaging Center Fondation FondaMental [Créteil] Hopital de Bohars - CHRU Brest Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Neuropsychiatrie : recherche épidémiologique et clinique Fondation FondaMental [Créteil] Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée
• Publié dans Journal of Psychiatric Research le 26/10/2020

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Résumé : Objective: In addition to heredity, exposure to early-life adversity is an important predisposing risk factor of suicidal behaviour. Although the association between Childhood Trauma (CT) and suicide risk is well documented, interactions between CT and suicidal behaviour in Treatment-Resistant Depression (TRD) populations have received little coverage. This study aimed to evaluate i) association between CT and suicidal behaviour in a TRD population, and ii) the role of personality traits and impulsiveness as potential factors of mediation in these associations. Methods: Patients were recruited from a cohort of the French network of TRD expert centers. Depressive symptom severity, CT, suicidal behaviour, personality traits, and impulsiveness were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Childhood Trauma Questionnaire (CTQ), the Columbia Suicide Severity Rating Scale (CSSRS), the Structured Clinical Interview for DSM-IV, the Big Five Inventory, and the Barratt Impulsivness Scale (BIS) respectively. Results: Among the 256 patients with a baseline CTQ, in relation to suicide risk for the current depressive episode, we found an association with the total CTQ scores mediated by the intensity of the current episode in a model adjusted for age and sex (total effect: β = 0.171; p = 0.011, direct effect: β = 0.135; p = 0.043; indirect effect: β = 0.036; p = 0.048). Focusing on CT subtypes, we detected an association between suicide risk and physical neglect in a model adjusted for age and sex (β = 0.301; p = 0.002), without any mediation by the intensity of the current episode. There was no mediation effect from personality traits nor impulsiveness. With regards to CSSRS to assess suicidal ideation, we did not find any association with the total CTQ score and CT subtype scores. Conclusion: We report a strong association between suicidal behaviour and CT (in particular childhood physical neglect) in a TRD population.

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Fichiers liés : S0022395620311638.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/02/2021
• Auteurs : Loic BethencourtWalid DabachineVincent DejouyZakaria LalmicheKarl NeubergerIssam IbnouhseinSandrine ChereauCarole MathelinNicolas SavyPhilippe Saint-PierreNicolas Bousquet
• Organismes : Laboratoire de Probabilités, Statistique et Modélisation Quantmetry [Paris] Quantmetry [Paris] Quantmetry [Paris] Quantmetry [Paris] Quantmetry [Paris] Hôpitaux Universitaires de Strasbourg Hôpitaux Universitaires de Strasbourg Institut de Mathématiques de Toulouse UMR5219 Institut de Mathématiques de Toulouse UMR5219 Institut Universitaire de Technologie - Paul Sabatier Laboratoire de Probabilités, Statistique et Modélisation Quantmetry [Paris] EDF R&D
• Publié dans IEEE Access le 25/10/2020

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Résumé : This article describes the preparation of a clinical study on a connected medical device dedicated to facilitate the prevention of lymphedema for patients treated for breast cancer after axillary lymph node dissection (ALND), and to alert them of any manifestation or resurgence in order to prevent its aggravation. A simulator of the entire physical process called digital twin has been developed for this purpose, in a hardware-in-the-loop framework. Statistical calibration of its input parameters, by stochastic inversion and using sensitivity studies, led to establish one or more measurement protocols allowing to capture the signal on a mobile device (phone or tablet) and to detect signal breaks that are physically signicant. The measured signal makes it possible to report quickly on the worsening of the patient's condition and to warn the therapists within a very reasonable period of time. The general methodology of this work seems to us to be easily reproducible in the preparation of clinical studies of other types for connected devices, which aim to develop measurement protocols limiting the often signicant cost of such studies. One of the immediate prospects of this work is the initiation of a clinical study on different patients who have been treated by surgery for breast cancer, after improving the robustness of the design of the prototype to take into account the uncertainties affecting the measurements.

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Fichiers liés : Article-final-IEEE-Access.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/02/2021
• Auteurs : Virginie BarrusseMagali BessonePierre BoninPierre BrunetLoïc CadietPhilippe ComteMarie-Dominique CouzinetSégolène DébarreAlain DuplouyAram MardirossianJoseph MorselNathalie SigotGuillaume SimiandMyriam TsikounasJean-Philippe Garric
• Organismes : Centre de recherches de l'Institut de Démographie de l'Université Paris 1 Institut des sciences juridique et philosophique de la Sorbonne - UMR 8103 Institut de Recherche juridique de la Sorbonne André Tunc Institut de Recherche juridique de la Sorbonne André Tunc Université Paris 1 Panthéon-Sorbonne Université Paris 1 Panthéon-Sorbonne Institut des sciences juridique et philosophique de la Sorbonne - UMR 8103 Géographie-cités Trajectoires - UMR 8215 Université Paris 1 Panthéon-Sorbonne Centre d'Histoire et d'Anthropologie du Droit Laboratoire de Médiévistique Occidentale de Paris Université Paris 1 Panthéon-Sorbonne Philosophie, Histoire et Analyse des Représentations Économiques Université Paris 1 Panthéon-Sorbonne Université Paris 1 Panthéon-Sorbonne Centre d'histoire du XIXe siècle Histoire culturelle et sociale de l'art
• Publié dans Journal of interdisciplinary history of ideas le 25/10/2020

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Résumé : Quand sommes-nous des " historiens " ? Quand faisons-nous de l'histoire ? Faut-il être le premier, pour faire la seconde ? Sous la présidence d'un historien, une quinzaine de représentants des sciences humaines et sociales pratiquées à l'Université Paris 1 Panthéon-Sorbonne ont librement débattu de leurs usages scientifiques, de la manière dont ils se définissent institutionnellement, de la place de l'histoire et du rapport au passé dans leurs domaines respectifs, ainsi que dans leurs cursus et leurs carrières. En développant conjointement ces questions, ils ont cherché à faire bouger les lignes, à échapper aux différentes configurations de l'actuel " conflit des facultés " et des hiérarchies disciplinaires (histoire vs sciences auxiliaires). Loin de toute épistémologie essentialiste, l'intention de cette conversation était de réfléchir sur les méthodes, mais aussi sur les conditions, les possibilités et les limites du dialogue actuel entre les disciplines.

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Fichiers liés : 5624-Article Text-17275-1-10-20210226.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/02/2021
• Auteurs : Kartasheva-Ebertz DariaGaston JesinthaLoriane Lair-MehiriPierre-Philippe MassaultOlivier ScattonJean-Christophe VaillantVladimir Alexei MorozovStanislas PolSylvie Lagaye
• Organismes : Immunobiologie des Cellules dendritiques Immunobiologie des Cellules dendritiques Immunobiologie des Cellules dendritiques Hôpital Cochin [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Robert Koch Institute [Berlin] Hôpital Cochin [AP-HP] Immunobiologie des Cellules Dendritiques
• Publié dans World journal of hepatology le 14/02/2020

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Résumé : BACKGROUND Liver fibrosis can result in end-stage liver failure and death. AIM To examine human liver fibrogenesis and anti-fibrotic therapies, we evaluated the three dimensional ex vivo liver slice (LS) model. METHODS Fibrotic liver samples (F0 to F4 fibrosis stage according to the METAVIR score) were collected from patients after liver resection. Human liver slices (HLS) were cultivated for up to 21 days. Hepatitis C virus (HCV) infection, alcohol (ethanol stimulation) and steatosis (palmitate stimulation) were examined in fibrotic (F2 to F4) liver slices infected (or not) with HCV. F0-F1 HLS were used as controls. At day 0, either ursodeoxycholic acid (choleretic and hepatoprotective properties) and/or α-tocopherol (antioxidant properties) were added to standard of care on HLS and fibrotic liver slices, infected (or not) with HCV. Expression of the biomarkers of fibrosis and the triglyceride production were checked by quantitative reverse transcription polymerase chain reaction and/or enzyme-linked immunosorbent assay. RESULTS The cultures were viable in vitro for 21 days allowing to study fibrosis inducers and to estimate the effect of anti-fibrotic drugs. Expression of the biomarkers of fibrosis and the progression to steatosis (estimated by triglycerides production) was increased with the addition of HCV and /or ethanol or palmitate. From day 15 of the follow-up studies, a significant decrease of both transforming growth factor β-1 and Procol1A1 expression and triglycerides production was observed when a combined anti-fibrotic treatment was applied on HCV infected F2-F4 LS cultures. CONCLUSION These results show that the human three dimensional ex vivo model effectively reflects the in vivo processes in damaged human liver (viral, alcoholic, nonalcoholic steatohepatitis liver diseases) and provides the proof of concept that the LS examined model permits a rapid evaluation of new anti-fibrotic therapies when used alone or in combination

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Fichiers liés : WJH-13-187.pdf

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