Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 27/02/2021
• Auteurs : Daria Kartasheva-EbertzJesintha GastonLoriane Lair-MehiriPierre-Philippe MassaultOlivier ScattonJean-Christophe VaillantVladimir Alexei MorozovStanislas PolSylvie Lagaye
• Organismes : Immunobiologie des Cellules dendritiques Immunobiologie des Cellules dendritiques Immunobiologie des Cellules dendritiques Chirurgie digestive, hépato-biliaire et endocrinienne [CHU Cochin] CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université - Faculté de Médecine CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université - Faculté de Médecine Robert Koch Institute [Berlin] Immunobiologie des Cellules dendritiques Immunobiologie des Cellules dendritiques
• Publié dans World journal of hepatology le 14/02/2020

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Résumé : Background: Liver fibrosis can result in end-stage liver failure and death.Aim: To examine human liver fibrogenesis and anti-fibrotic therapies, we evaluated the three dimensional ex vivo liver slice (LS) model.Methods: Fibrotic liver samples (F0 to F4 fibrosis stage according to the METAVIR score) were collected from patients after liver resection. Human liver slices (HLS) were cultivated for up to 21 days. Hepatitis C virus (HCV) infection, alcohol (ethanol stimulation) and steatosis (palmitate stimulation) were examined in fibrotic (F2 to F4) liver slices infected (or not) with HCV. F0-F1 HLS were used as controls. At day 0, either ursodeoxycholic acid (choleretic and hepatoprotective properties) and/or α-tocopherol (antioxidant properties) were added to standard of care on HLS and fibrotic liver slices, infected (or not) with HCV. Expression of the biomarkers of fibrosis and the triglyceride production were checked by quantitative reverse transcription polymerase chain reaction and/or enzyme-linked immunosorbent assay.Results: The cultures were viable in vitro for 21 days allowing to study fibrosis inducers and to estimate the effect of anti-fibrotic drugs. Expression of the biomarkers of fibrosis and the progression to steatosis (estimated by triglycerides production) was increased with the addition of HCV and /or ethanol or palmitate. From day 15 of the follow-up studies, a significant decrease of both transforming growth factor β-1 and Procol1A1 expression and triglycerides production was observed when a combined anti-fibrotic treatment was applied on HCV infected F2-F4 LS cultures.Conclusion: These results show that the human three dimensional ex vivo model effectively reflects the in vivo processes in damaged human liver (viral, alcoholic, nonalcoholic steatohepatitis liver diseases) and provides the proof of concept that the LS examined model permits a rapid evaluation of new anti-fibrotic therapies when used alone or in combination.

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Fichiers liés : WJH-13-187.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/02/2021
• Auteurs : Coline ArnouldVincent RocherAnne-Laure FinouxThomas ClouaireKevin LiFelix ZhouPierre CaronPhilippe-Emmanuel MangeotEmiliano P. RicciRaphaël MouradJames HaberDaan NoordermeerGaëlle Legube
• Organismes : Unité de biologie Moléculaire, Cellulaire et du Développement Unité de biologie Moléculaire, Cellulaire et du Développement Unité de biologie Moléculaire, Cellulaire et du Développement Unité de biologie Moléculaire, Cellulaire et du Développement Brandeis University Brandeis University Unité de biologie Moléculaire, Cellulaire et du Développement Centre International de Recherche en Infectiologie Laboratoire de biologie et modélisation de la cellule Unité de biologie Moléculaire, Cellulaire et du Développement Brandeis University Institut de Biologie Intégrative de la Cellule Unité de biologie Moléculaire, Cellulaire et du Développement
• Publié dans Nature le 29/10/2020

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Résumé : The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX (γH2AX), which act as seeds for the formation of DNA-damage response foci1. It is unclear how these foci are rapidly assembled to establish a 'repair-prone' environment within the nucleus. Topologically associating domains are a key feature of 3D genome organization that compartmentalize transcription and replication, but little is known about their contribution to DNA repair processes2,3. Here we show that topologically associating domains are functional units of the DNA damage response, and are instrumental for the correct establishment of γH2AX-53BP1 chromatin domains in a manner that involves one-sided cohesin-mediated loop extrusion on both sides of the DSB. We propose a model in which H2AX-containing nucleosomes are rapidly phosphorylated as they actively pass by DSB-anchored cohesin. Our work highlights the importance of chromosome conformation in the maintenance of genome integrity and demonstrates the establishment of a chromatin modification by loop extrusion.

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Fichiers liés : EMS114641.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/02/2021
• Auteurs : Gonzague de PinieuxMarie KaranianFrançois Le LoarerSophie Le GuellecSylvie ChabaudPhilippe TerrierCorinne BouvierMaxime BatistellaAgnès NeuvilleYves-Marie RobinJean-Francois EmileAnne MoreauFrederique LarousserieAgnès LerouxNathalie StockMarick LaeFrancoise CollinNicolas WeinbreckSébastien AubertFlorence MishellanyCeline Charon-BarraSabrina CroceLaurent DoucetIsabelle Quintin-RouetMarie-Christine ChateauCeline BazilleIsabelle ValoBruno ChetailleNicolas OrtonneAnne BrouchetPhilippe RochaixAnne DemuretJean-Pierre GhnassiaLenaig MescamNicolas MacagnoIsabelle Birtwisle-PeyrottesChristophe DelfourEmilie AngotIsabelle PommepuyDominique RanchereClaire Chemin-AiriauMyriam Jean-DenisYohan FayetJean-Baptiste CourrègesNouria MesliJuliane BerchoudMaud ToulmondeAntoine ItalianoAxel Le CesneNicolas PenelFrancoise DucimetiereFrancois GouinJean-Michel CoindreJean-Yves Blay
• Organismes : Hôpital Trousseau Centre de Recherche en Cancérologie de Lyon Institut Bergonié [Bordeaux] Centre de Recherches en Cancérologie de Toulouse Oncopole Claudius Regaud Centre Léon Bérard [Lyon] Département de biologie et pathologie médicales [Gustave Roussy] Marseille medical genetics - Centre de génétique médicale de Marseille Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM] Nanomédecine Régénérative Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 Hôpital Ambroise Paré [AP-HP] Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie Institut national de recherches archéologiques préventives Cités, Territoires, Environnement et Sociétés Hôpital Cochin [AP-HP] Centre de Recherche en Automatique de Nancy Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Département de Biologie et pathologie des tumeurs [Centre Georges-François Leclerc] Pôle d’Excellence Jean Louis Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Service de pathologie [CHU Lille] Imagerie Moléculaire et Stratégies Théranostiques Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] CHU Dijon Institut Bergonié [Bordeaux] Marseille medical genetics - Centre de génétique médicale de Marseille Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM]
• Publié dans PLoS ONE le 25/10/2020

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Résumé : Background Since 2010, nationwide networks of reference centers for sarcomas (RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases of sarcomas and connective tumors of intermediate malignancy (TIM) in France. Methods The nationwide incidence of sarcoma or TIM (2013–2016) was measured using the 2013 WHO classification and confirmed by a second independent review by expert pathologists. Simple clinical characteristics, yearly variations and correlation of incidence with published clinical trials are presented and analyzed. Results Over 150 different histological subtypes are reported from the 25172 patients with sarcomas (n = 18712, 74,3%) or TIM (n = 6460, 25.7%), with n = 5838, n = 6153, n = 6654, and n = 6527 yearly cases from 2013 to 2016. Over these 4 years, the yearly incidence of sarcomas and TIM was therefore 70.7 and 24.4 respectively, with a combined incidence of 95.1/10 6 /year, higher than previously reported. GIST, liposarcoma, leiomyosarcomas, undifferentiated sarcomas represented 13%, 13%, 11% and 11% of tumors. Only GIST, as a single entity had a yearly incidence above 10/10 6 /year. There were respectively 30, 64 and 66 different histological subtypes of sarcomas or TIM with an incidence ranging from 10 to 1/10 6 , 1–0.1/10 6 , or < 0.1/10 6 /year respectively. The 2 latter incidence groups represented 21% of the patients with 130 histotypes. Published phase III and phase II clinical trials (p<10 −6 ) are significantly higher with sarcomas subtypes with an incidence above 1/10 6 per. Conclusions This nationwide registry of sarcoma patients, with exhaustive histology review by sarcoma experts, shows that the incidence of sarcoma and TIM is higher than reported, and that tumors with a very low incidence (1<10 6 /year) are less likely to be included in clinical trials.

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Fichiers liés : 09695e1b62e2cd0291eef344bcb969ea.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/02/2021
• Auteurs : Anne-Sophie MichalletRémi LetestuMagali Le Garff-TavernierCarmen AaneiMichel TicchioniMarie-Sarah DilhuydyFabien SubtilValerie RouilleBeatrice MaheKamel LaribiBruno VillemagneGilles André SallesOlivier TournilhacAlain DelmerChristelle PortoisBrigitte PegourieVeronique LeblondCécile TomowiakSophie de GuibertFrederique Orsini PiocelleAnne BanosPhilippe CarassouGuillaume CartronLuc-Matthieu ForneckerLoic YsebaertCaroline DartigeasMalgorzata Truchan-GraczykJean-Pierre VilqueThérèse AurranFlorence CymbalistaStéphane LepretreVincent LevyFlorence Nguyen-KhacPierre Feugier
• Organismes : Centre Léon Bérard [Lyon] Service d'hématologie biologique [Avicenne] CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Bordeaux Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Hospices Civils de Lyon CHU Clermont-Ferrand Service d'hématologie [Reims] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire [CHU Grenoble] CHU Pitié-Salpêtrière [AP-HP] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Centre Hospitalier de la Côte Basque Centre hospitalier régional de Metz-Thionville Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Service d'hématologie [Tours] Centre Hospitalier Universitaire d'Angers Laboratoire d'Hématologie Biologique [CHU Caen] Institut Paoli-Calmettes Service d'hématologie biologique [Avicenne] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Unité de recherche clinique [Avicenne] CHU Pitié-Salpêtrière [AP-HP] Service d'Hématologie [CHRU Nancy] Nutrition-Génétique et Exposition aux Risques Environnementaux
• Publié dans Blood le 28/10/2020

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Résumé : Abstract Trials assessing first-line, fixed-duration approaches in chronic lymphocytic leukemia (CLL) are yielding promising activity, but few long-term data are available. We report follow-up data from a phase 2 trial (ICLL07 FILO) in previously untreated, medically fit patients (N = 135). Patients underwent obinutuzumab-ibrutinib induction for 9 months; then, following evaluation (N = 130 evaluable), those in complete remission and with bone marrow measurable residual disease (BM MRD) <0.01% (n = 10) received ibrutinib for 6 additional months; those in partial remission and/or with BM MRD ≥0.01%, the majority (n = 120), also received 4 cycles of immunochemotherapy (fludarabine/cyclophosphamide-obinutuzumab). Beyond end of treatment, responses were assessed every 3 month and peripheral blood MRD every 6 months. At median follow-up 36.7 months from treatment start, progression-free and overall survival rates (95% confidence interval) at 3 years were 95.7% (92.0% to 99.5%) and 98% (95.1% to 100%), respectively. Peripheral blood MRD <0.01% rates were 97%, 96%, 90%, 84%, and 89% at months 16, 22, 28, 34, and 40, respectively. No new treatment-related or serious adverse event occurred beyond end of treatment. Thus, in previously untreated, medically fit patients with CLL, a fixed-duration (15 months), MRD-guided approach achieved high survival rates, a persistent MRD benefit beyond the end of treatment, and low long-term toxicity. This trial was registered at www.clinicaltrials.gov as #NCT02666898.

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• Type de publi. : Article dans une revue
• Date de publi. : 24/02/2021
• Auteurs : Philippe ThuillierMeriem MaajemUlrike SchickFrédérique Blanc-BeguinSimon HennebicqJean-Philippe MetgesPierre-Yves SalaunVéronique KerlanDavid BourhisRonan Abgral
• Organismes : Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Université de Brest Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Groupe d'Etude de la Thrombose de Bretagne Occidentale Hôpital de la Cavale Blanche - CHRU Brest Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale
• Publié dans Clinical Nuclear Medicine le 30/10/2020

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Résumé : Introduction The aim of this study was to study the feasibility of an SUV-based 177 Lu-DOTATATE SPECT/CT quantification and to assess the correlation of different parameters with the corresponding measured on 68 Ga-DOTATOC PET/CT in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors (WD-GEP-NET) treated with peptide receptor radionuclide therapy. Patients and Methods Patients with WD-GEP-NET who benefited from a pretherapeutic 68 Ga-DOTATOC PET/CT and a 177 Lu-DOTATATE SPECT/CT after the cycle 1 of peptide receptor radionuclide therapy were prospectively included. SPECT/CT acquisitions were performed on a system calibrated with a conversion factor of 9.48 counts/MBq per second and were reconstructed with an iterative algorithm allowing quantification using the SPECTRA Quant software (MIM Software, Cleveland, OH). For each patient, different SUV parameters were recorded on both PET/CT (Ga parameters) and SPECT/CT (Lu parameters) for comparison: physiological uptakes (liver/spleen), tumor uptake (1–10/patient; SUV max , SUV mean , SUV peak , MTV), tumor-to-liver and tumor-to-spleen ratios according to liver/spleen SUV max and SUV mean (TLR max , TLR mean , TSR max , and TSR mean , respectively). Results Ten patients (8 female; 2 male) aged from 50 to 83 years presenting with a metastatic progressive WD-GEP-NET (7 small intestine, 2 pancreas, 1 rectum) were included. Median values of lesional Lu-SUV were significantly lower than the corresponding Ga-SUV ( P < 0.001), whereas median values of lesional Lu-MTV, Lu-TLR, and Lu-TSR were significantly higher than the corresponding Ga-MTV, Ga-TLR, and Ga-TSR ( P < 0.02). Pearson correlation coefficients were strong for both SUV and MTV parameters (0.779–0.845), weak for TLR parameters (0.365–0.394), and moderate-to-strong for TSR parameters (0.676–0.750). Conclusions Our results suggest the feasibility of 177 Lu-DOTATATE SPECT/CT quantification in clinical practice and show a strong correlation of several SUV-based parameters with the corresponding in 68 Ga-DOTATOC PET/CT.

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• Type de publi. : Article dans une revue
• Date de publi. : 23/02/2021
• Auteurs : Solafah AbdallaStéphane BenoistLeon MaggioriPhilippe ZerbibJérémie H. LefevreQuentin DenostAdeline GermainEddy CotteLaura Beyer-BerjotHelene CorteVéronique DesfourneauxAmine RahiliJean-Pierre DuffasKarine PautratChristine DenetValérie BridouxGuillaume MeuretteJean-Luc FaucheronJérôme LoriauFrancoise GuillonÉric VicautYves PanisAntoine Brouquet
• Organismes : Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Maladies et hormones du système nerveux Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hopital Saint-Louis [AP-HP] Lille Inflammation Research International Center - U 995 CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire de Bordeaux Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy] Centre Hospitalier Lyon Sud [CHU - HCL] Hôpital Nord [CHU - APHM] Hopital Saint-Louis [AP-HP] Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes] Centre Hospitalier Universitaire de Nice Chirurgie Générale et Digestive [Rangueil] Service de Chirurgie d'Oncologie Digestive [CHU Lariboisière] Institut Mutualiste de Montsouris Service de Chirurgie Digestive [CHU Rouen] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Département de chirurgie digestive et de l'urgence Centre Hospitalier Universitaire [CHU Grenoble] Centre hospitalier Saint-Joseph [Paris] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Lariboisière-Fernand-Widal [APHP] Université Paris Diderot - Paris 7 Hôpital Beaujon [AP-HP] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Maladies et hormones du système nerveux
• Publié dans Colorectal Disease le 05/04/2023

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Résumé : OBJECTIVE: Postoperative morbidity is high in patients operated on for Crohn's disease (CD) complicated by malnutrition. This study aimed to evaluate the impact of preoperative enteral nutritional support (PENS) on postoperative outcome in patients with CD complicated by malnutrition included in a prospective nationwide cohort. METHODS: Malnutrition was defined as body mass index <18 kg/m2 RESULTS: Among 592 patients included, 149 were selected. In the intention-to-treat population including 20 (13.4%) patients with PENS failure after PSM, 78 'upfront surgery' and 71 'PENS'-matched patients were compared, with no significant difference in the primary endpoint. Perforating CD and preoperative intra-abdominal fistula were associated with PENS failure [37.5 vs 16.1% (P = 0.047) and 41.2% vs 16.2% (P = 0.020), respectively]. After exclusion of these 20 patients, PSM was used to compare 45 'upfront surgery' and 51 'PENS'-matched patients, with a significantly decreased rate of intra-abdominal septic complications and/or temporary defunctioning stoma in the PENS group (19.6 vs 42.2%, P = 0.016). CONCLUSIONS: Preoperative enteral nutritional support is associated with a trend but no conclusive evidence of a reduction in intra-abdominal septic complications and/or requirement for defunctioning stoma. Patients with perforating CD complicated with malnutrition are at risk of PENS failure.

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• Type de publi. : Article dans une revue
• Date de publi. : 22/02/2021
• Auteurs : Julian KuehnertAnne MangeneyYann CapdevilleJean-Pierre VilotteÉléonore StutzmannEmmanuel ChaljubEl-Madani AissaouiPatrice BoissierChristophe BrunetPhilippe KowalskiFrédéric Lauret
• Organismes : Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Laboratoire de Planétologie et Géodynamique [UMR 6112] Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut des Sciences de la Terre Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris
• Publié dans Journal of Geophysical Research: Earth Surface le 28/10/2020

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Résumé : Rockfalls generate seismic signals that can be used to detect and monitor rockfall activity. Event locations can be estimated on the basis of arrival times, amplitudes, or polarization of these seismic signals. However, surface topography variations can significantly influence seismic wave propagation and hence compromise results. Here, we specifically use the signature of topography on the seismic signal to better constrain the source location. Seismic impulse responses are predicted using Spectral Element based simulation of three dimensional wave propagation in realistic geological media. Subsequently, rockfalls are located by minimizing the misfit between simulated and observed inter station energy ratios. The method is tested on rockfalls at Dolomieu crater, Piton de la Fournaise volcano, Reunion Island. Both single boulder impacts and distributed granular flows are successfully located, tracking the complete rockfall trajectories by analyzing the signals in sliding time windows. Results from the highest frequency band (here 13-17 Hz) yield the best spatial resolution, making it possible to distinguish detachment positions less than 100 m apart. By taking into account surface topography, both vertical and horizontal signal components can be used. Limitations and the noise robustness of the location method are assessed using synthetic signals. Precise representation of the topography controls the location resolution, which is not significantly affected by the assumed impact direction. Tests on the network geometry reveal best resolution when the seismometers triangulate the source. We conclude that this method can improve the monitoring of rockfall activity in real time once a simulated database for the region of interest is created.

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Fichiers liés : essoar.10503303.3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/02/2021
• Auteurs : Matthieu WargnyLouis PotierPierre GourdyMatthieu PichelinCoralie AmadouPierre-Yves BenhamouJb BonnetLyse BordierOlivier BourronClaude ChaumeilNicolas ChevalierPatrice DarmonBlandine DelenneDelphine DemarsyMarie DumasOlivier DupuyAnna Flaus-FurmaniukJean-François GautierAnne-Marie GuedjNathalie JeandidierEtienne LargerJean-Philippe Le BerreMyriam LungoNathanaëlle MontanierPhilippe MoulinFrançoise PlatVincent RigalleauNancy Kentish-BarnesDominique Seret-BéguéPierre SérusclatSarra SmatiJean-François ThébautBlandine TramuntCamille VatierFritz-Line VelayoudomBruno VergesPatrice WiniszewskiAudrey ZabulonPierre-Antoine GourraudRonan RousselBertrand CariouSamy Hadjadj
• Organismes : ITX - unité de recherche de l'institut du thorax CIC - CHU Bichat Service Diabétologie [CHU Toulouse] Institut des Maladies Métaboliques et Casdiovasculaires ITX - unité de recherche de l'institut du thorax Centre Hospitalier Sud Francilien Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée Centre Hospitalier Régional Universitaire [Montpellier] Hôpital d'Instruction des Armées Begin [Saint-Mandé, France] CHU Pitié-Salpêtrière [AP-HP] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research ITX - unité de recherche de l'institut du thorax ITX - unité de recherche de l'institut du thorax
• Publié dans Diabetologia le 01/11/2020

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Résumé : Aims/hypothesis This is an update of the results from the previous report of the CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). Methods The CORONADO initiative is a French nationwide multicentre study of patients with diabetes hospitalised for COVID-19 with a 28-day follow-up. The patients were screened after hospital admission from 10 March to 10 April 2020. We mainly focused on hospital discharge and death within 28 days. Results We included 2796 participants: 63.7% men, mean age 69.7 ± 13.2 years, median BMI (25th-75th percentile) 28.4 (25.0-32.4) kg/m 2. Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of participants, respectively. Within 28 days, 1404 (50.2%; 95% CI 48.3%, 52.1%) were discharged from hospital with a median duration of hospital stay of 9 (5-14) days, while 577 participants died (20.6%; 95% CI 19.2%, 22.2%). In multivariable models, younger age, routine metformin therapy and longer symptom duration on admission were positively associated with discharge. History of microvascular complications, anticoagulant routine therapy, dyspnoea on admission, and higher aspartate aminotransferase, white cell count and C-reactive protein levels were associated with a reduced chance of discharge. Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors. Conclusions/interpretation In patients with diabetes hospitalised for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period. Trial registration Clinicaltrials.gov identifier: NCT04324736 Keywords Admission plasma glucose. COVID-19. Death. Diabetes. Discharge. HbA 1c. Home discharge. Mechanical ventilation Matthieu Wargny and Louis Potier contributed equally to the manuscript and must be considered as joint first authors. Bertrand Cariou and Samy Hadjadj contributed equally to the manuscript and must be considered as joint senior authors. A complete list of the CORONADO trial investigators is provided in the electronic supplementary material (ESM).

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Fichiers liés : 125_2020_Article_5351.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/02/2021
• Auteurs : Coline ArnouldVincent RocherAnne-Laure FinouxThomas ClouaireKevin LiFelix ZhouPierre CaronPhilippe-Emmanuel MangeotEmiliano P. RicciRaphaël MouradJames HaberDaan NoordermeerGaëlle Legube
• Organismes : Expression de l'ARN chez les virus et les eucaryotes - RNA Expression in Viruses and Eukaryotes [CIRI] Laboratoire de biologie et modélisation de la cellule Unité de biologie Moléculaire, Cellulaire et du Développement
• Publié dans Nature le 29/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 17/02/2021
• Auteurs : Adrien Le FrancPierre CarpentierJean-Philippe ChancelierMichel de Lara
• Organismes : Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique École nationale des ponts et chaussées Optimisation et commande Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique
• Publié dans Energy Systems le 22/10/2020

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Résumé : Inserting renewable energy in the electric grid in a decentralized manner is a key challenge of the energy transition. However, at local scale, both production and demand display erratic behavior, which makes it delicate to match them. It is the goal of Energy Management Systems (EMS) to achieve such balance at least cost. We present EMSx, a numerical benchmark for testing control algorithms for the management of electric microgrids equipped with a photovoltaic unit and an energy storage system. EMSx is made of three key components: the EMSx dataset, provided by Schneider Electric, contains a diverse pool of realistic microgrids with a rich collection of historical observations and forecasts; the EMSx mathematical framework is an explicit description of the assessment of electric microgrid control techniques and algorithms; the EMSx software EMSx.jl is a package, implemented in the Julia language, which enables to easily implement a microgrid controller and to test it. All components of the benchmark are publicly available, so that other researchers willing to test controllers on EMSx may reproduce experiments easily. Eventually, we showcase the results of standard microgrid control methods, including Model Predictive Control, Open Loop Feedback Control and Stochastic Dynamic Programming.

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Fichiers liés : emsx_hal_v3.pdf

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