Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 17/02/2021
• Auteurs : Adrien Le FrancPierre CarpentierJean-Philippe ChancelierMichel de Lara
• Organismes : Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique École nationale des ponts et chaussées Optimisation et commande Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique
• Publié dans Energy Systems le 22/10/2020

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Résumé : Inserting renewable energy in the electric grid in a decentralized manner is a key challenge of the energy transition. However, at local scale, both production and demand display erratic behavior, which makes it delicate to match them. It is the goal of Energy Management Systems (EMS) to achieve such balance at least cost. We present EMSx, a numerical benchmark for testing control algorithms for the management of electric microgrids equipped with a photovoltaic unit and an energy storage system. EMSx is made of three key components: the EMSx dataset, provided by Schneider Electric, contains a diverse pool of realistic microgrids with a rich collection of historical observations and forecasts; the EMSx mathematical framework is an explicit description of the assessment of electric microgrid control techniques and algorithms; the EMSx software EMSx.jl is a package, implemented in the Julia language, which enables to easily implement a microgrid controller and to test it. All components of the benchmark are publicly available, so that other researchers willing to test controllers on EMSx may reproduce experiments easily. Eventually, we showcase the results of standard microgrid control methods, including Model Predictive Control, Open Loop Feedback Control and Stochastic Dynamic Programming.

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Fichiers liés : emsx_hal_v3.pdf

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 17/02/2021
• Auteurs : Babak AbiRoberto AcciarriMario AceroGiorge AdamovDavid AdamsMarco AdinolfiZubayer AhmadJhanzeb AhmedTyler AlionSaul Alonso MonsalveChristoph AltJohn AndersonCostas AndreopoulosMichael P AndrewsManoa AndriamiradoFenompanirina AndrianalaSofia AndringaArtur AnkowskiJack AnthonyIliescu AntoniuMaria AntonovaStefan AntuschAlfredo Aranda FernandezAkitaka ArigaLukas ArnoldManuel ArroyaveJonathan AsaadiAdam AurisanoVladimir AushevDario AutieroFarrukh AzfarAshley BackHenning BackJohn BackChris BackhousePaolo BaessoLinda BagbyRaphaël BajouSupraja BalasubramanianPierre BaldiBindu BambahFernando BaraoGabriela BarenboimGary J BarkerWayne BarkhouseChristopher BarnesGiles BarrJuan Barranco MonarcaNuno BarrosJoshua BarrowAmit BashyalVincent BasqueFatih BayJohn BeacomEdouard BechetoilleBiswaranjan BeheraLeo BellantoniGiorgio BellettiniVincenzo BelliniOlga BeltramelloNektarios BenekosFrancisco Bento NevesJoshua BergerSophie BerkmanPaolo BernardiniRoman BernerHans-Gerd BernsSergio BertolucciMinerba BetancourtMaharnab BhattacharjeeBipul BhuyanSimone BiagiJianming BianMatteo BiassoniKurt BieryBurak BilkiMary BishaiAlexander BitadzeAndrew BlakeBeatriz Blanco SiffertFlor de Maria BlaszczykGerald C BlazeyEdward BlucherJan BoissevainSara BolognesiTimothy BoltonMaurizio BonesiniMathieu BongrandFiliberto BoniniAlexander BoothChris BoothStefania BordoniAran BorkumTommaso BoschiNilay BostanPetr BourSteve B BoydDaniel BoydenJuraj BracinikDavide BragaDominic BrailsfordAndrew BrandtJohan BremerChris BrewEldwan BrianneStephen BriceClaudia BrizzolariCarl BrombergGustaaf BrooijmansJim BrookeAlan BrossGiulia BrunettiNorman BuchananHoward BuddDavide CaiuloPaolo CalafiuraJacob CalcuttMarius CalinSteven CalvezEnrique CalvoLeslie CamilleriAlessio CaminataMario CampanelliDavid CaratelliGabriella CariniBruno CarlusPaolo CarnitiIvan Caro TerrazasHector CarranzaAndrés CastilloCesar CastromonteCarla CattadoriF. CavalierFlavio CavannaSandro CentroGiuseppe CeratiAlberto CervelliAnselmo Cervera VillanuevaMichel ChalifourEtienne ChardonnetAnimesh ChatterjeeSubhasish ChattopadhyayJorge ChavesHucheng ChenMu-Chun ChenYifan ChenDaniel CherdackCheng-Yi ChiSam ChildressAna ChiriacescuKihyeon ChoSandhya ChoubeyAnne ChristensenDavid ChristianGeorgios ChristodoulouEric ChurchPeter ClarkeThomas CoanAlfredo CoccoJ.A.B. CoelhoErin ConleyJanet M ConradMark ConveryLuke CorwinPhilippe CotteLucien CremaldiLinda CremonesiJose I Crespo-AnadónEsteban CristaldoRyan CrossClara CuestaYanou CuiDavid CussansMieczyslaw DabrowskiHelio da MottaQuentin DavidGavin DaviesStefano DaviniJaime DawsonKaushik DeRogerio de AlmeidaPaul DebbinsIsabelle de BonisM Patrick DecowskiAndre de GouveaPedro de HolandaIker de Icaza AstizAlexander DeistingPaul de JongAlain DelbartDavid DelepineMaritza DelgadoAndrea Dell'AcquaPatrick de LurgioDavid DemuthSteve DennisChris DenshamAlbert de RoeckValentina de RomeriJoris Jan de VriesRanjan DharmapalanFelix DiazJorge S DiazSergio Di DomizioLetizia Di GiulioPengfei DingLea Di NotoCarla DistefanoRichard DiurbaMilind DiwanZelimir DjurcicNeha DokaniaMichelle J DolinskiLaura DomineDaniel DouglasFrancois DrielsmaDominique DuchesneauKirsty DuffyPatrick DunneTim DurkinHongyue DuyangOlexiy DvornikovDaniel A DwyerAlexandre S DyshkantMichael EadsDaniel EdmundsJonathan EischSandrine EmeryAntonio EreditatoCarlos O EscobarLorena Escudero SanchezJustin EvansKevin EwartAnthony EzeribeKevin FaheyAndrea FalconeChristian FarneseYasaman FarzanJulian FelixEnrique Fernandez-MartinezPablo Fernandez MenendezFederico FerraroLaura FieldsFrank FilthautRory FitzpatrickWill FlanaganBonnie FlemingRobert FlightJack FowlerWalt FoxJiri FrancKurt FrancisDomenico FrancoJohn FreemanJulian FreestoneJack FriedAlex FriedlandStu FuessIvan FuricAndrew FurmanskiHugh GallagherAna Gallego-RosNiccolo GalliceVyacheslav GalymovEnrico GamberiniTrevor GambleRaj GandhiReddy GandrajulaShanshan GaoDiego Garcia-GamezMiguel García-PerisSteven GardinerDan GastlerGuanqun GeBruno GelliAdamo GendottiStephen GentZahra Ghorbani-MoghaddamDaniele GibinInes Gil-BotellaClaude GirerdAnjan Kumar GiriOlga GogotaMichael GoldSowjanya GollapinniKeith GollwitzerRicardo GomesLaura Vanessa Gomez BermeoLuz Gomez FajardoFrancesco GonnellaJuan Alberto Gonzalez-CuevasMaury GoodmanOwen GoodwinSrubabati GoswamiClaudio GottiEvgueni GoudzovskiCarl GraceMathew GrahamRik GranEverardo GranadosAlan GrantChristopher GrantNick GrantDiego GratieriPatrick GreenSteven GreenLeland GreenlerJoel GreerDerlis Gregor RecaldeClark GriffithMicah GrohJames GrudzinskiKatarzyna GrzelakWenqiang GuVictor GuarinoRoxanne GuenetteAlberto GuglielmiBing GuoK K GuthikondaRafael GutierrezPawel GuzowskiMarcelo GuzzoSunwoo GwonAlec HabigHaleh HadavandRoger HaenniAlan HahnJennifer HaighJames HaistonThomas HamernikPhilip HamiltonJiyeon HanKristian HarderDebbie HarrisJeffrey HartnellTakyua HasegawaRobert HatcherEric HazenAnne HeaveyKarsten HeegerKarol HennessyChristopher HayesMiguel Angel Hernandez MorquechoKenneth HernerLars HertelJeremy HewesAaron Higuera PichardoTony HillStephen HillierAlexander HimmelJames HoffChristian HohlAnna HolinEric HoppeGlenn Horton-SmithMatheus HostertAdrien HourlierBruce HowardRyan HowellJunting HuangJunying HuangJustin HugonGregory IlesRobert IllingworthAra IoannisianRan ItayAlexander IzmaylovEric JamesFilip JedinyCésar Jesús-VallsXiangpan JiSergio JiménezAlexandru JipaConnor JohnsonRandy JohnsonBenjamin JonesSebastian JonesChang Kee JungThomas JunkYeon-Jae JwaMonireh KabirnezhadAsher KabothI KadenkoFelipe KamiyaGeorgia KaragiorgiMark KarolakYannis KaryotakisSeiji KasaiSiva KasettiLane KashurNarine KazaryanEdward KearnsPaul KeenerKevin KellyErnesto KempWes KetchumSteve H KettellMarat KhabibullinAlexei KhotjantsevArsen KhvedelidzeBonnie KingBrian KirbyMike KirbyJoshua KleinKevin KoehlerLisa KoernerSam KohnPatrick KollerMike KordoskyThomas KoscUmut KoseV Alan KosteleckyKunal KothekarFrank KrennrichIgor KresloYury KudenkoVitaly A KudryavtsevSergey KulaginJason KumarRajeev KumarChatura KuruppuVaclav KusThomas KutterKenneth LandeCharles LaneKarol LangThomas LangfordPierre LasorakDavid LastChiara LastoriaAndy LaundrieIonel LazanuRyan LazurTrung LeJohn LearnedP. LebrunGiovanna Lehmann MiottoRalf LehnertM A Leigui de OliveiraMichael LeytonLingge LiShaorui LiShirley W LiTeng LiYichen LiHeng-Ye LiaoCheng-Ju Stephen LinShih-Kai LinAdam ListerBryce LittlejohnSarah LockwitzTimothy LoewMilos LokajicekIrakli LomidzeKen LongKai LooDavid LorcaTom LordJohn M LoseccoWilliam LouisKam-Biu LukXiao LuoNicolas LurkinThorsten LuxVitor Prestes LuzioDavid MacfarlaneAna Amelia MachadoPedro MachadoChristopher Thomas MaciasJolie R MacierAntonello MaddalenaPeter MadiganSteve MagillKendall MahnAmélia MaioJames MaloneyGianni MandrioliJosé ManeiraLaura ManentiSteve ManlyAnthony MannKonstantinos ManolopoulosMaria Manrique PlataAlberto MarchionniWilliam MarcianoDanny MarfatiaCamillo MarianiJelena MaricicFranciole MarinhoAlysia MarinoMarvin MarshakChris MarshallJohn MarshallJacques MarteauJusto Martin-AlboNorman MartinezDavid Martinez CaicedoSergey MartynenkoKatie MasonAndrew MastbaumMehedi MasudShigenobu MatsunoJames MatthewsChristopher MaugerNicoletta MauriKonstantinos MavrokoridisRoberto MazzaAnna MazzacaneEdoardo MazzucatoElaine MccluskeyNicola McconkeyKevin McfarlandClark McgrewAndrew McnabAlexander MefodievPoonam MehtaPantelis MelasMichele MellinatoOlga MenaScott MenaryLucas Mendes SantosTracy McaskillA MenegolliGuang MengMark MessierWilliam MetcalfMatthew MewesHolger MeyerTing MiaoGregory MichnaThijs MiedemaJost MigendaRadovan MilincicWilliam H. MillerJoshua MillsCody MilneOleg MineevOmar MirandaSandeep MiryalaC Shekhar MishraSanjib R MishraAaron MislivecDimitar MladenovIrina MocioiuKristian MoffatNiccolo MoggiRukmani MohantaTanaz MohayaiNikolai MokhovJorge MolinaLaura Molina BuenoAlessandro MontanariClaudio MontanariDavid MontanariLuis Montano ZetinaJarrett MoonMichael MooneyDeywis MorenoBen MorganCasandra MorrisChris MosseyErdem MotukCélio MouraJoel MousseauWei MuLeon MualemJustin MuellerMathew MuetherStuart MufsonFranz MuheimAlan MuirMike MulhearnHajime MuramatsuSebastien MurphyJim MusserJane NachtmanMikayel NalbandyanRaja NandakumarDonna NaplesShinya NaritaNitish NayakMiquel Nebot-GuinotLina NecibKentaro NegishiJeff NelsonJake NesbitMarzio NessiDavid NewboldMitch NewcomerDuane NewhartRyan NicholEvan NinerKurtis NishimuraAndrew NormanRich NorthropPau NovellaJaroslaw NowakMichael OberlingAndres Olivares del CampoAndrew OlivierYasar OnelYuriy OnishchukJordan OttLuca PaganiSandip PakvasaOrnella PalamaraSandro PalestiniJonathan PaleyMarco PallaviciniCarmen PalomaresEmilija PanticVittorio PaoloneVaia PapadimitriouRiccardo PapaleoAntonis PapanestisSudarshan ParamesvaranStephen ParkeZohreh ParsaMihaela ParvuSilvia PascoliLaura PasqualiniJaroslaw PasternakJoleen PaterCheryl PatrickLaura PatriziiRyan PattersonSimon John PattonThomas PatzakAjib PaudelBob PaulosLaura PaulucciZarko PavlovicGreg PawloskiDavid PayneViktor PecSimon PeetersYves PenichotElisabetta PennacchioAldo PenzoOrlando PeresRyan PattersonDaniel PersheyGianluigi PessinaGianluca PetrilloCatia PettaRoberto PettiFrancesco PiastraLuke PickeringFrancesco PietropaoloJames PillowRobert PlunkettRonald PolingXavier PonsNavaneeth PoonthottathilStephen PordesMaxim PotekhinRenato PotenzaBaba PotukuchiJuergen PozimskiMichele PozzatoSuprabh PrakashTarun PrakashSebastien PrinceDenis PugnereXin QianJennifer L RaafVeljko RadekaJonas RademackerBalint RadicsAleena RafiqueEric RaguzinMousam RaiMiriama RajaoalisoaIgor RakhnoLaza RakotondravohitraYorck A RamachersRegina RameikaManuel Alejandro Ramirez DelgadoBryan RamsonA RappoldiGl RaselliPeter RatoffSylvain RavatJ.S. RealBrian RebelDavid RedondoMarina Reggiani-GuzzoTyler RehakJuergen ReichenbacherS ReitznerAndrew RenshawSergio ResciaFilippo ResnatiAidan ReynoldsGiorgio RiccobeneLogan RiceKeith RielageYann-Axel RigautDavid RiveraLeon RochesterMarco RodaPhilip RodriguesManual Jesus Rodriguez AlonsoJairo Rodriguez RondonAlison J RoethHannah RogersSalvador Rosauro-AlcarazM RossellaJogesh RoutSamiran RoyAndre RubbiaCarlo RubbiaBrooke RussellJames RussellDaniel RuterboriesRuben SaakyanSabrina SacerdotiTwymun SaffordNarendra SahuPaola SalaNicholas SamiosMayly SanchezDavid SandersDavid SankeySamuel SantanaMarvin Santos-MaldonadoNiki SaoulidouPiera SapienzaCarlos SarastyIna SarcevicGeoffrey SavageVladimir SavinovAlberto ScaramelliAndrew ScarffAndrea ScarpelliTom SchafferHeidi SchellmanPhilip SchlabachDavid SchmitzKate ScholbergAnne SchukraftEttore SegretoJon SensenigIlsoo SeongAntonino SergiDavide SgalabernaMichael H ShaevitzSheeba ShafaqHans SharmaRahul SharmaTerri ShawClaire Shepherd-ThemistocleousSeodong ShinDean ShooltzRobert ShrockLaurent SimardNikolaos SimosJames SinclairGleb SinevJaydip SinghJyotsna SinghRoland SiposF W SippachGabriele SirriAndriaseta SitrakaKim SiyeonAdryanna SmithAndrew SmithErica SmithPaul SmithJan SmolikMichael SmyPavel SnopokMônica Soares NunesHenry SobelMitch SoderbergCarlos Solano SalinasStefan Söldner-RemboldNicholas SolomeyVladimir SolovovWalter SondheimMichel SorelJose Soto-OtonAlexandre SousaKarel SoustruznikFabio SpagliardiMaura SpanuJoshua SpitzNeil Jc SpoonerKyle SpurgeonRichard StaleyMichelle StancariLuca StancoHerbert M SteinerJames StewartBen StillwellJason StockFrancesca StockerTyler StokesMatthew StraitThomas StraussSergei StriganovAlexander StuartDon SummersAntonio SurdoVasja SusicLouise SuterConcetta Maria SuteraRobert SvobodaBarbara SzczerbinskaAndrzej SzelcRichard TalagaHirohisa TanakaBeatriz Tapia OreguiAlexander TapperSalman TariqE. TatarRex TayloeAbraham Meles TekluMatteo TentiKazuhiro TeraoChristoph TernesFrancesco TerranovaGemma TesteraAlessandro TheaJoshua ThompsonCraig ThornSteven C TimmJacob ToddAlessandra TonazzoJoao Torres de Mello NetoMarta TortiMariam TortolaFrancesco TortoriciDante TotaniMatthew ToupsChristos TouramanisJason TrevorWladyslaw TrzaskaYun-Tse TsaiZviadi TsamalaidzeKa Vang TsangNikolozi TsveravaSerhan TufanliCraig TullE. TyleyMartin TzanovMelissa UchidaJon UrheimTracy UsherMark R VaginsPatricia VahleGustavo ValdiviessoZoya VallariJose ValleSofia VallecorsaRick van BergRichard van de WaterDavid Vanegas ForeroFilippo VaraniniDanaisis VargasGary VarnerJustin VaselGeorges VasseurKamran VaziriSandro VenturaAntonio VerdugoStefano VerganiMilo VermeulenMarco VerzocchiHenrique Vieira de SouzaChiara VignoliCristovao VilelaBrett VirenTomas VrbaTomasz WachalaAbigail WaldronMichael WallbankHanguo WangJingbo WangYi WangNoah VaughanKarl WarburtonDavid WarnerMorgan WasckoStefano VerganiAlan WatsonPierce WeatherlyAlfons WeberMichele WeberHanyu WeiAmanda WeinsteinDan WenmanMatthew WetsteinAndy WhiteLeigh WhiteheadDenver WhittingtonMichael WilkingCallum WilkinsonZachary WilliamsFergus WilsonRobert WilsonJeremy WolcottTaritree WongjiradKevin WoodLynn WoodElizabeth WorcesterMatthew WorcesterClarence WretWanwei WuGuang YangShaokai YangTingjun YangNikolai YershovKatsuya YoneharaTim YoungBo YuJae YuJaroslav ZalesakLaura ZambelliBruno ZamoranoAndrea ZaniLuis ZazuetaGeralyn ZellerJoseph ZennamoKyle ZeugChao ZhangManhong ZhaoElena ZhivunGuanying ZhuEric ZimmermanMarco ZitoStefano ZucchelliJosef ZuklinVishnu ZutshiRobert Zwaska
• Organismes : Institut de Physique des 2 Infinis de Lyon AstroParticule et Cosmologie Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de l'Accélérateur Linéaire Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie Laboratoire de l'Accélérateur Linéaire Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon AstroParticule et Cosmologie Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie AstroParticule et Cosmologie Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers

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Résumé : The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume II of this TDR, DUNE Physics, describes the array of identified scientific opportunities and key goals. Crucially, we also report our best current understanding of the capability of DUNE to realize these goals, along with the detailed arguments and investigations on which this understanding is based. This TDR volume documents the scientific basis underlying the conception and design of the LBNF/DUNE experimental configurations. As a result, the description of DUNE's experimental capabilities constitutes the bulk of the document. Key linkages between requirements for successful execution of the physics program and primary specifications of the experimental configurations are drawn and summarized. This document also serves a wider purpose as a statement on the scientific potential of DUNE as a central component within a global program of frontier theoretical and experimental particle physics research. Thus, the presentation also aims to serve as a resource for the particle physics community at large.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 17/02/2021
• Auteurs : Coline ArnouldVincent RocherAnne-Laure FinouxThomas ClouaireKevin LiFelix ZhouPierre CaronPhilippe MangeotEmiliano P. RicciRaphaël MouradJames HaberDaan NoordermeerGaëlle LegubePhilippe-Emmanuel Mangeot
• Organismes : Unité de biologie Moléculaire, Cellulaire et du Développement Unité de biologie Moléculaire, Cellulaire et du Développement Unité de biologie Moléculaire, Cellulaire et du Développement Unité de biologie Moléculaire, Cellulaire et du Développement Brandeis University Brandeis University Unité de biologie Moléculaire, Cellulaire et du Développement Centre International de Recherche en Infectiologie Laboratoire de biologie et modélisation de la cellule Unité de biologie Moléculaire, Cellulaire et du Développement Brandeis University Université Paris-Saclay Unité de biologie Moléculaire, Cellulaire et du Développement Unité de biologie Moléculaire, Cellulaire et du Développement
• Publié dans Nature le 29/10/2020

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Résumé : The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX (γH2AX), which act as seeds for the formation of DNA-damage response foci1. It is unclear how these foci are rapidly assembled to establish a ‘repair-prone’ environment within the nucleus. Topologically associating domains are a key feature of 3D genome organization that compartmentalize transcription and replication, but little is known about their contribution to DNA repair processes2,3. Here we show that topologically associating domains are functional units of the DNA damage response, and are instrumental for the correct establishment of γH2AX–53BP1 chromatin domains in a manner that involves one-sided cohesin-mediated loop extrusion on both sides of the DSB. We propose a model in which H2AX-containing nucleosomes are rapidly phosphorylated as they actively pass by DSB-anchored cohesin. Our work highlights the importance of chromosome conformation in the maintenance of genome integrity and demonstrates the establishment of a chromatin modification by loop extrusion.

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Fichiers liés : Arnould_2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/02/2021
• Auteurs : Eva OgireOlivier DiazPierre-Olivier VidalainVincent LotteauPhilippe DesprèsMarjolaine Roche
• Organismes : Processus Infectieux en Milieu Insulaire Tropical Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] Processus Infectieux en Milieu Insulaire Tropical Processus Infectieux en Milieu Insulaire Tropical
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : La Reunion island in the South West Indian Ocean is now endemic for dengue followingthe introduction of dengue virus serotype 2 (DENV-2) cosmopolitan-I genotype in 2017. DENV-2infection causes a wide spectrum of clinical manifestations ranging from flu-like disease to severedengue. The nonstructural glycoprotein 1 (NS1) has been identified as playing a key role in denguedisease severity. The intracellular NS1 exists as a homodimer, whereas a fraction is driven towardsthe plasma membrane or released as a soluble hexameric protein. Here, we characterized the NS1glycoproteins from clinical isolates DES-14 and RUN-18 that were collected during the DENV-2epidemics in Tanzania in 2014 and La Reunion island in 2018, respectively. In relation to hepa-totropism of the DENV, expression of recombinant DES-14 NS1 and RUN-18 NS1 glycoproteins wascompared in human hepatoma Huh7 cells. We observed that RUN-18 NS1 was poorly stable inHuh7 cells compared to DES-14 NS1. The instability of RUN-18 NS1 leading to a low level of NS1secretion mostly relates to lysine residues on positions 272 and 324. Our data raise the issue of theconsequences of a defect in NS1 stability in human hepatocytes in relation to the major role of NS1 inthe pathogenesis of the DENV-2 infection.

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Fichiers liés : ijms-22-01951.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/02/2021
• Auteurs : Anne-Laure Larroque-LombardÉtienne ChatelutJean-Pierre DelordDiane-Charlotte ImbsPhilippe RochaixBertrand Jean-ClaudeBen Allal
• Organismes : Research Institute of the McGill University Health Centre Centre de Recherches en Cancérologie de Toulouse Oncopole Claudius Regaud Oncopole Claudius Regaud Simulation & Modelling : Adaptive Response for Therapeutics in Cancer Oncopole Claudius Regaud Université de Provence - Aix-Marseille 1 Centre de Recherches en Cancérologie de Toulouse
• Publié dans Pharmaceuticals le 26/10/2020

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Résumé : The clinical use of cytotoxic agents is plagued by systemic toxicity. We report a novel approach that seeks to design a “combi-molecule” to behave as an alkylating agent on its own and to undergo acid-catalyzed conversion to two bioactive species at a pH range akin to that of a tumor microenvironment: an AL530 prototype was synthesized and we studied its ability to release a chlorambucil analogue (CBL-A) plus a potent mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitor (PD98059) at different pHs in buffered solutions, plasma and tumors. Its potency was compared in vitro with CBL+PD98059 (SRB assay) and in vivo in a xenograft model. Its target modulation was studied by western blotting and immunohistochemistry. AL530 released PD98059+CBL-A at mild acidic pH and in vitro was fivefold more potent than CBL and three-to-fivefold more potent than CBL+PD98059. In vivo it released high levels of PD98059 in tumors with a tumor/plasma ratio of five. It induced γ-H2AX phosphorylation and blocked pErk1,2, indirectly indicating its ability to damage DNA and modulate MEK. It induced significant tumor delay and less toxicity at unachievable doses for CBL and CBL+PD98059. We demonstrated the feasibility of a pH-labile combi-molecule capable of delivering high MEK inhibitor concentration in tumors, damaging DNA therein, and inducing tumor growth delay.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/02/2021
• Auteurs : Philippe van de PerreJean-Pierre MolesNicolas NagotEdouard TuaillonPierre‐emmanuel CeccaldiAmeena GogaAndrew J PrendergastNigel Rollins
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology University of Pretoria [South Africa] Queen Mary University of London Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse]
• Publié dans Pediatric Allergy and Immunology le 02/11/2020

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Résumé : As breastfeeding is of utmost importance for child development and survival, identifying whether breast milk is a route of transmission for human viruses is critical. Based on the principle of Koch’s postulate, we propose an analytical framework to determine the plausibility of viral transmission by breast milk. This framework is based on five criteria: viral infection in children receiving breastmilk from infected mothers; the presence of virus, viral antigen or viral genome in the breast milk of infected mothers; the evidence for the virus in breast milk being infectious; the attempts to rule out other transmission modalities; and the reproduction of viral transmission by oral inoculation in an animal model. We searched for evidence in published reports to determine whether the 5 criteria are fulfilled for 16 human viruses that are suspected to be transmissible by breast milk. We considered breast milk transmission is proven if all 5 criteria are fulfilled, as probable if 4 of the 5 criteria are met, as possible if 3 of the 5 criteria are fulfilled and as unlikely if less than 3 criteria are met. Only five viruses have proven transmission through breast milk: human T‐cell lymphotropic virus 1, human immunodeficiency virus, human cytomegalovirus, dengue virus and Zika virus. The other 11 viruses fulfilled some but not all criteria and were categorized accordingly. Our framework analysis is useful for guiding public health recommendations and for identifying knowledge gaps amenable to original experiments

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Fichiers liés : Revisiting koch's postulate to determine the plausibility of viral transmission.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/02/2021
• Auteurs : Giske OpheimAnja van Der KolkKarin Markenroth BlochAlbert ColonKathryn DavisThomas HenryJacobus F.A. JansenStephen JonesJullie PanKarl RösslerJoel SteinMaria StrandbergSiegfried TrattnigPierre-Francois van de MoorteleMaria Isabel VargasIrène WangFabrice BartolomeiNeda BernasconiAndrea BernasconiBoris C BernhardtIsabella Björkman-BurtscherMirco CosottiniSandhitsu DasLucie Hertz-PannierSara InatiMichael JurkiewiczAli KhanShuli LiangRuoyun Emily MaSrinivasan MukundanHeath PardoeLars PinborgJonathan PolimeniJean‐philippe RanjevaEsther SteijversSteven StufflebeamTim VeersemaAlexandre VignaudNatalie VoetsSerge VulliemozChristopher WigginsRong XueRenzo GuerriniMaxime Guye
• Organismes : Neurobiology Research Unit, Department of Neurology Rigshospitalet Copenhagen University Hospital, UCPH Faculty of Health and Medical Sciences, UCPH Utrecht Brain Center [UMC] Department of Radiology University Medical Center Utrecht Skane University Hospital [Lund] Department of Neurology Neurophysiology and Neurosurgery, ACE Kempenhaeghe/MUMC, Heeze/Maastricht PENN Epilepsy Center Department of Neurology University of Minnesota, Minneapolis Department of Radiology and Nuclear Medicine Maastricht University Medical Center School for Mental Health and Neuroscience [Maastricht] Imaging Institute [Cleveland] University of Pittsburgh Medical University of Vienna = Medizinische Universität Wien Department of Radiology Hospital of the University of Pennsylvania, Philadelphia Skane University Hospital [Lund] Medical University of Vienna = Medizinische Universität Wien Medical University of Vienna = Medizinische Universität Wien Center for Magnetic Resonance Research [Minneapolis] Neuroradiology Division, Diagnostic Unit University Hospitals and Faculty of Medicine of Geneva Epilepsy Center Cleveland Clinic Institut de Neurosciences des Systèmes Service de neurophysiologie clinique [Hôpital de la Timone - APHM] McConnell Brain Imaging Centre McConnell Brain Imaging Centre McConnell Brain Imaging Centre Göteborgs Universitet = University of Gothenburg Department of Translational Research on New Technologies in Medicine and Surgery Department of Neurology University of Pennsylvania, Philadelphia Building large instruments for neuroimaging: from population imaging to ultra-high magnetic fields EEG Section, NINDS, NIH, Bethesda University of Western Ontario Imaging Research Laboratories, Robarts Research Institute, London Functional Neurosurgery Department Beijing Children's Hospital of Capital Medical University, Beijing Center for Magnetic Resonance Research [Minneapolis] Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston Epilepsy Clinic, Department of Neurology, Rigshospitalet Copenhagen University Hospital Neurobiology Research Unit, Department of Neurology Rigshospitalet Copenhagen University Hospital, UCPH Harvard-MIT Division of Health Sciences and Technology [Cambridge] Athinoula A. Martinos Center for Biomedical Imaging Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Scannexus Ultrahigh Field MRI Research Center, Maastricht Harvard-MIT Division of Health Sciences and Technology [Cambridge] Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology and Nuclear Medicine Meander Medical Center, Amersfoort Laboratoire d'Imagerie et de Spectroscopie Wellcome Trust Centre for Integrative Neuroimaging Université de Genève = University of Geneva Scannexus Ultrahigh Field MRI Research Center, Maastricht Beijing Normal University Università degli Studi di Firenze = University of Florence = Université de Florence IMAGO 7 Foundation, Florence Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM]
• Publié dans Neurology le 01/11/2020

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Résumé : Identifying a structural brain lesion on MRI has important implications in epilepsy and is the most important factor that correlates with seizure freedom after surgery in patients with drug-resistant focal onset epilepsy. However, at conventional magnetic field strengths (1.5 and 3T), only approximately 60%–85% of MRI examinations reveal such lesions. Over the last decade, studies have demonstrated the added value of 7T MRI in patients with and without known epileptogenic lesions from 1.5 and/or 3T. However, translation of 7T MRI to clinical practice is still challenging, particularly in centers new to 7T, and there is a need for practical recommendations on targeted use of 7T MRI in the clinical management of patients with epilepsy. The 7T Epilepsy Task Force—an international group representing 21 7T MRI centers with experience from scanning over 2,000 patients with epilepsy—would hereby like to share its experience with the neurology community regarding the appropriate clinical indications, patient selection and preparation, acquisition protocols and setup, technical challenges, and radiologic guidelines for 7T MRI in patients with epilepsy. This article mainly addresses structural imaging; in addition, it presents multiple nonstructural MRI techniques that benefit from 7T and hold promise as future directions in epilepsy. Answering to the increased availability of 7T MRI as an approved tool for diagnostic purposes, this article aims to provide guidance on clinical 7T MRI epilepsy management by giving recommendations on referral, suitable 7T MRI protocols, and image interpretation.

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• Type de publi. : Article dans une revue
• Date de publi. : 12/02/2021
• Auteurs : Tom Le VoyerCyril GitiauxFrançois Jérôme AuthierChristine BodemerIsabelle MelkiPierre QuartierFlorence AeschlimannArnaud IsapofJean Philippe HerbeuvalVincent BondetJean-Luc CharuelMarie-Louise FrémondDarragh DuffyMathieu P RoderoBrigitte Bader-Meunier
• Organismes : Service d'immuno-hématologie pédiatrique [CHU Necker] Human genetics of infectious diseases : Mendelian predisposition Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Institut Mondor de Recherche Biomédicale Département de pathologie [Mondor] Service de dermatologie [CHU Necker] Service d'immuno-hématologie pédiatrique [CHU Necker] Laboratory of neurogenetics and neuroinflammation AP-HP Hôpital universitaire Robert-Debré [Paris] Service d'immuno-hématologie pédiatrique [CHU Necker] Imagine - Institut des maladies génétiques (IHU) Service d'immuno-hématologie pédiatrique [CHU Necker] Imagine - Institut des maladies génétiques (IHU) CHU Trousseau [APHP] Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques Immunologie Translationnelle - Translational Immunology lab CHU Pitié-Salpêtrière [AP-HP] Laboratory of neurogenetics and neuroinflammation Immunologie Translationnelle - Translational Immunology lab Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques Service d'immuno-hématologie pédiatrique [CHU Necker] Imagine - Institut des maladies génétiques (IHU)
• Publié dans Rheumatology le 29/10/2020

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Résumé : Objective To evaluate the efficacy and safety of Janus kinase inhibitors (JAKis) in JDM. Methods We conducted a single-centre retrospective study of patients with JDM treated by JAKi with a follow-up of at least 6 months. Proportion of clinically inactive disease (CID) within 6 months of JAKi initiation was evaluated using PRINTO criteria and skin Disease Activity Score. Serum IFN-α concentration was measured by Simoa assay. Results Nine refractory and one new-onset patients with JDM treated with ruxolitinib (n = 7) or baricitinib (n = 3) were included. The main indications for treatment were refractory muscle involvement (n = 8) and ulcerative skin disease (n = 2). CID was achieved in 5/10 patients (two/two anti-MDA5, three/four anti-NXP2, zero/three anti-TIF1γ-positive patients) within 6 months of JAKi introduction. All responders could withdraw plasmatic exchange, immunoadsorption and other immunosuppressive drugs. The mean daily steroid dose decreased from 1.1 mg/kg (range 0.35–2 mg/kg/d) to 0.1 (range, 0–0.3, P = 0.008) in patients achieving CID, and was stopped in two. Serum IFN-α concentrations were elevated in all patients at the time of treatment initiation and normalized in both responder and non-responder. A muscle biopsy repeated in one patient 26 months after the initiation of JAKi, showed a complete restoration of muscle endomysial microvascular bed. Herpes zoster and skin abscesses developed in three and two patients, respectively. Conclusion JAKis resulted in a CID in a subset of new-onset or refractory patients with JDM and may dramatically reverse severe muscle vasculopathy. Overall tolerance was good except for a high rate of herpes zoster infection.

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Fichiers liés : JAKiDMRheumatologyREVISEDFINAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 11/02/2021
• Auteurs : Anne-Sophie GilleCatherine PatratJean-Hugues DalleFrançoise BernaudinCéline ChalasMony FahdCamille JeanHarry LezeauLydia RiouVéronique DrouineaudAnnabel Paye-JaouenAnnie KamdemBénédicte NevenCécile ArnaudSaba AzarnoushKarima YakoubenSabine SarnackiMariane de MontalembertEva Maria ComperatGilles LenaourMathilde SibonyNathalie DhédinDaniel VaimanJean-Philippe WolfCatherine PatratPierre FouchetCatherine PoirotVirginie Barraud-Lange
• Organismes : Université Paris Cité Université Paris Cité
• Publié dans Blood le 28/10/2020

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Résumé : In these two short reports, the authors approach the issue of whether hydroxyurea (HU) use in young males has major irreversible effects on sperm production. Joseph et al analyzed and compared sperm parameters in male patients with sickle cell disease (SCD) who were exposed or not exposed to HU before puberty. They report semen abnormalities in all patients but no differences between groups. Independently, Gille et al provide evidence for the lack of in vivo HU-related decreases in the spermatogonial pool in biopsy specimens from young males with SCD but evidence for a negative effect of SCD itself. Together, these reports suggest that the use of HU in young males does not adversely affect fertility.

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Fichiers liés : 1-s2.0-S0006497121002834-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 11/02/2021
• Auteurs : P. RichetteAugustin LatourteJérémie SellamDaniel WendlingMuriel PipernoPhilippe GoupilleYves-Marie PersFlorent EymardSebastien OttavianiPaul OrnettiRené-Marc FlipoBruno FautrelOlivier PeyrJean Pierre BertolaÉric VicautXavier Chevalier
• Organismes : Service de Rhumatologie [CHU Lariboisière] Service de Rhumatologie [CHU Lariboisière] Pathologies biliaires, fibrose et cancer du foie [CRSA] Service de Rhumatologie Université Claude Bernard Lyon 1 CHU Trousseau [Tours] Centre Hospitalier Régional Universitaire [Montpellier] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Service de rhumatologie [CHU Henri Mondor] Université Paris-Est Créteil Val-de-Marne - Paris 12 AP-HP - Hôpital Bichat - Claude Bernard [Paris] Service de Rhumatologie (CHU de Dijon) Service de rhumatologie[Lille] Institut Pierre Louis d'Epidémiologie et de Santé Publique Service de Rhumatologie [CHU Lariboisière] Chugai Pharma France, Paris La Défense Hôpital Lariboisière-Fernand-Widal [APHP] Service de rhumatologie [CHU Henri Mondor] Université Paris-Est Créteil Val-de-Marne - Paris 12
• Publié dans Annals of the Rheumatic Diseases le 26/10/2020

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Résumé : Objective: To evaluate the efficacy of tocilizumab, an antibody against IL-6 receptor, in patients with hand osteoarthritis. Methods: This was a multicentre, 12-week, randomised, double-blind, placebo-controlled study from November 2015 to October 2018. Patients with symptomatic hand osteoarthritis (pain ≥40 on a 0–100 mm visual analogue scale (VAS) despite analgesics and non-steroidal anti-inflammatory drugs; at least three painful joints, Kellgren-Lawrence grade ≥2) were randomised to receive two infusions 4 weeks apart (weeks 0 and 4) of tocilizumab (8 mg/kg intravenous) or placebo. The primary endpoint was changed in VAS pain at week 6. Secondary outcomes included the number of painful and swollen joints, duration of morning stiffness, patients’ and physicians’ global assessment and function scores. Results: Of 104 patients screened, 91 (45 to tocilizumab and 46 to placebo; 82% women; mean age 64.4 (SD 8.7) years) were randomly assigned and 79 completed the 12-week study visit. The mean change between baseline and week 6 on the VAS for pain (primary outcome) was −7.9 (SD 19.4) and −9.9 (SD 20.1) in the tocilizumab and placebo groups (p=0.7). The groups did not differ for any secondary outcomes at weeks 4, 6, 8 or 12. Overall, adverse events were slightly more frequent in the tocilizumab than placebo group. Conclusion: Tocilizumab was no more effective than placebo for pain relief in patients with hand osteoarthritis.

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