Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Giuliana AmaddeoRaffaele BrustiaManon AllaireMarie LequoyClémence HollandeHélène RegnaultLorraine BlaiseNathalie Ganne-CarriéOlivier SérorEdouard LarreyChetana LimOlivier ScattonSanaa El MouhadiViolaine OzenneFrançois PayePierre BalladurAnthony DohanPierre-Philippe MassaultStanislas PolMarco Dioguardi BurgioValérie VilgrainAilton SepulvedaFrancois CauchyAlain LucianiDaniele SommacaleVincent LeroyFrancoise Roudot-ThoravalMohamed BouattourJean-Charles Nault
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de recherche sur l'Inflammation Centre de recherche sur l'Inflammation Centre de recherche sur l'Inflammation Centre de Recherche des Cordeliers
• Publié dans JHEP Reports Innovation in Hepatology le 07/09/2020

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Résumé : Background & Aims: Patients affected by hepatocellular carcinoma (HCC) represent a vulnerable population during the COVID-19 pandemic and may suffer from altered allocation of healthcare resources. The aim of this study was to determine the impact of the COVID-19 pandemic on the management of patients with HCC within 6 referral centres in the metropolitan area of Paris, France. Methods: We performed a multicentre, retrospective, cross-sectional study on the management of patients with HCC during the first 6 weeks of the COVID-19 pandemic (exposed group), compared with the same period in 2019 (unexposed group). We included all patients discussed in multidisciplinary tumour board (MTB) meetings and/or patients undergoing a radiological or surgical programmed procedure during the study period, with curative or palliative intent. Endpoints were the number of patients with a modification in the treatment strategy, or a delay in decision-to-treat. Results: After screening, n = 670 patients were included (n = 293 exposed to COVID, n = 377 unexposed to COVID). Fewer patients with HCC presented to the MTB in 2020 (p = 0.034) and fewer had a first diagnosis of HCC (n = 104 exposed to COVID, n = 143 unexposed to COVID, p = 0.083). Treatment strategy was modified in 13.1% of patients, with no differences between the 2 periods. Nevertheless, 21.5% vs. 9.5% of patients experienced a treatment delay longer than 1 month in 2020 compared with 2019 (p <0.001). In 2020, 7.1% (21/293) of patients had a diagnosis of an active COVID-19 infection: 11 (52.4%) patients were hospitalised and 4 (19.1%) patients died. Conclusions: In a metropolitan area highly impacted by the COVID-19 pandemic, we observed fewer patients with HCC, and similar rates of treatment modification, but with a significantly longer treatment delay in 2020 vs. 2019.

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Fichiers liés : 1-s2.0-S2589555920301336-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Federica RibaldiDaniele AltomareJorge JovicichClarissa FerrariAgnese PiccoFrancesca Benedetta PizziniAndrea SoricelliAnna MegaAntonio FerrettiAntonios DrevelegasBeatriz BoschBernhard MüllerCamillo MarraCarlo CavaliereDavid Bartrés-FazFlavio NobiliFranco AlessandriniFrederik BarkhofHélène Gros-DagnacJean‐philippe RanjevaJens WiltfangJoost KuijerJulien SeinKarl-Titus HoffmannLuca RoccatagliataLucilla ParnettiMagda TsolakiManos ConstantinidisMarco AielloMarco SalvatoreMartina MontaltiMassimo CauloMira DidicNúria BargalloOlivier BlinPaolo RossiniPeter SchonknechtPiero FloridiPierre PayouxPieter Jelle VisserRégis BordetRenaud LopesRoberto TarducciStephanie BomboisTilman HenschUte FiedlerJill RichardsonGiovanni FrisoniMoira Marizzoni
• Organismes : Centro San Giovanni di Dio, Fatebenefratelli, Brescia Laboratory of Neuroimaging of aging, Memory clinic and LANVIE Laboratory of Neuroimaging of aging, Memory clinic and LANVIE Center for Mind/Brain Sciences Centro San Giovanni di Dio, Fatebenefratelli, Brescia Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] Department of Diagnostics and Public Health [Verona] IRCCS SDN Napoli Centro San Giovanni di Dio, Fatebenefratelli, Brescia Department of Clinic Sciences and Bioimaging, University G. d'Annunzio Chieti-Pescara Interbalkan Medical Center of Thessaloniki Dept. of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer) Department of Child and Adolescent Psychiatry Department of Neuroscience, Catholic University, Roma IRCCS SDN Napoli Dept. of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer) Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] Department of Diagnostics and Public Health [Verona] Centre for Medical Image Computing Department of Radiology and Nuclear Medicine [Amsterdam] Toulouse NeuroImaging Center Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] University Medical Center Göttingen Department of Radiology and Nuclear Medicine [Amsterdam] Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Leipzig University / Universität Leipzig Centro San Giovanni di Dio, Fatebenefratelli, Brescia Università degli Studi di Perugia = University of Perugia Interbalkan Medical Center of Thessaloniki Interbalkan Medical Center of Thessaloniki IRCCS SDN Napoli IRCCS SDN Napoli Centro San Giovanni di Dio, Fatebenefratelli, Brescia Department of Clinic Sciences and Bioimaging, University G. d'Annunzio Chieti-Pescara Institut de Neurosciences des Systèmes Neurology Department, Hospital Clinic, IDIBAPS, Facultad de Medicina, Barcelona Institut de Neurosciences des Systèmes Dept. Neuroscience & Neurorehabilitation, IRCCS-San Raffaele-Pisana, Rome Leipzig University / Universität Leipzig Neuroradiology Unit, Perugia General Hospital, Perugia, Toulouse NeuroImaging Center Alzheimer Center Amsterdam Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Medical Physics Unit, Perugia General Hospital, Perugia Lille Neurosciences & Cognition - U 1172 Leipzig University / Universität Leipzig LVR-Clinic for Psychiatry and Psychotherapy, Institutes and Clinics of the University Duisburg-Essen, Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Laboratory of Neuroimaging of aging, Memory clinic and LANVIE Centro San Giovanni di Dio, Fatebenefratelli, Brescia
• Publié dans Magnetic Resonance Imaging le 27/10/2020

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Résumé : Brain vascular damage accumulate in aging and often manifest as white matter hyperintensities (WMHs) on MRI. Despite increased interest in automated methods to segment WMHs, a gold standard has not been achieved and their longitudinal reproducibility has been poorly investigated. The aim of present work is to evaluate accuracy and reproducibility of two freely available segmentation algorithms. A harmonized MRI protocol was implemented in 3T-scanners across 13 European sites, each scanning five volunteers twice (test-retest) using 2D-FLAIR. Automated segmentation was performed using Lesion segmentation tool algorithms (LST): the Lesion growth algorithm (LGA) in SPM8 and 12 and the Lesion prediction algorithm (LPA). To assess reproducibility, we applied the LST longitudinal pipeline to the LGA and LPA outputs for both the test and retest scans. We evaluated volumetric and spatial accuracy comparing LGA and LPA with manual tracing, and for reproducibility the test versus retest. Median volume difference between automated WMH and manual segmentations (mL) was -0.22[IQR = 0.50] for LGA-SPM8, -0.12[0.57] for LGA-SPM12, -0.09[0.53] for LPA, while the spatial accuracy (Dice Coefficient) was 0.29[0.31], 0.33[0.26] and 0.41[0.23], respectively. The reproducibility analysis showed a median reproducibility error of 20%[IQR = 41] for LGA-SPM8, 14% [31] for LGA-SPM12 and 10% [27] with the LPA cross-sectional pipeline. Applying the LST longitudinal pipeline, the reproducibility errors were considerably reduced (LGA: 0%[IQR = 0], p < 0.001; LPA: 0% [3], p < 0.001) compared to those derived using the cross-sectional algorithms. The DC using the longitudinal pipeline was excellent (median = 1) for LGA [IQR = 0] and LPA [0.02]. LST algorithms showed moderate accuracy and good reproducibility. Therefore, it can be used as a reliable cross-sectional and longitudinal tool in multi-site studies.

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Fichiers liés : Barkhof_Ribaldi.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Jean KanyTewfik BenkalfateLuc FavardPhilippe TeissierChristophe CharoussetPierre Henri FlurinBertrand CouletLaurent HubertJérôme GarretPhilippe ValentiJean David WerthelNicolas Bonnevialle
• Organismes : Clinique de l'union Clinique mutualiste La Sagesse CHU Trousseau [Tours] Clinique du sport de Bordeaux-Mérignac Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Lapeyronie [CHU Montpellier] Centre Hospitalier Universitaire d'Angers Hôpital Ambroise Paré [AP-HP]
• Publié dans Orthopaedics & Traumatology: Surgery & Research le 26/10/2020

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Résumé : Introduction: Osteoarthritis (OA) of the shoulder in under-50 year-olds is rare, and treatment is delicate. Shoulder replacement incurs frequent long-term risk of progression and a high revision rate, making it unsuited to young active patients. The aim of the present study was to determine the epidemiology of shoulder OA in under-50 year-olds and to assess the clinical results of the various treatment options. Hypothesis: The main study hypothesis was that well-conducted non-operative treatment can allow shoulder replacement to be postponed. The secondary hypothesis was that anatomic total shoulder arthroplasty (TSA) is the treatment of choice when other options fail. Materials and methods: A multicenter retrospective study included primary (POA) and post-instability osteoarthritis (PIOA) in patients aged≤50years at symptom onset. Exclusion criteria comprised post-traumatic OA, rheumatoid arthritis and necrosis. Two hundred and sixty-six patients for 273 shoulders were included from 13 shoulder surgery centers: 2 types of non-operative treatment (28 by platelet-rich plasma [PRP] and 88 by viscosupplementation), 73 arthroscopies, and 150 implantations (62 humeral hemiarthroplasties [HA], comprising 10 hemi-metal, 24 hemi-pyrocarbon and 28 hemi-resurfacing; 77 anatomic total prostheses, and 11 reverse prostheses). Minimum follow-up was 12 months for non-operative treatment and 24 months for arthroplasty (some patients having both). Endpoints comprised Constant score, Subjective Shoulder Value (SSV) and number of complications/revision procedures. Results: Mean age at treatment was 43 years (range, 23-65 years), with 75% male predominance. Symptom onset was earlier in PIOA than in POA: 36 vs. 39 years (range, 20-50 years). PRP and viscosupplementation postponed implantation by a mean 3.5 years in 86% of cases, as did arthroscopy in 56%. ER1 restriction was the most negative factor. At 74 months' follow-up for HA and 95 months for TSA, mean Constant score was significantly lower for HA (56 vs. 67; p=0.004), with higher rates of complications (31% vs. 11%) and implant exchange (13% vs. 9%). Discussion/conclusion: PRP, viscosupplementation and arthroscopy allow implantation to be postponed until the shoulder becomes stiff and painful. In case of failure, TSA is the most effective solution in the medium-term. Level of evidence: IV a; therapeutic study - investigating the results of treatment.

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• Type de publi. : Rapport
• Date de publi. : 01/02/2021
• Auteurs : Jean-François SoussanaClaire WeillPatrick CaronJean-Luc ChottePierre-Benoît JolyPramod AggarwalMonique AxelosImke de BoerThierry CaquetCarole CarantaPhilippe ChemineauChristine CherbutMathieu DenisJessica FanzoPatrick FlammarionJean-François GuéganChristophe C. GouelSégolène Halley Des FontainesOlivier HamantDavid HannahMarion HetheringtonChristian HuygheCyril KaoAntoine KremerPeter LangridgeDavid LeadleyMichael LeeMarcus LindnerAllison LocontoMauricio Antonio LopesValérie Masson-DelmotteAlan MatthewsRaoul MilleRobert J. NaimanRiboli ElioJohan SchotYouba SokonaAndrew StirlingDaniel ToméMaria Concetta TomeiSébastien TreyerSaskia VisserJacques WerySarah Whitmee
• Organismes : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Université de Montpellier Institut de Recherche pour le Développement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement International Maize and Wheat Improvement Center Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Wageningen University and Research [Wageningen] Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement International Science Council John’s Hopkins Berman Institute of Bioethics Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut de Recherche pour le Développement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement University of Birmingham [Birmingham] University of Leeds Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement University of Adelaide Université Paris-Saclay Rothamsted Research European Forest Institute Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés Brazilian Agricultural Research Corporation = Empresa Brasileira de Pesquisa Agropecuária Intergovernmental Panel on Climate Change Université Paris-Saclay Trinity College Dublin Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement University of Washington [Seattle] Imperial College London Universiteit Utrecht / Utrecht University [Utrecht] Intergovernmental Panel on Climate Change University of Sussex Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement National Research Council of Italy | Consiglio Nazionale delle Ricerche Institut du Développement Durable et des Relations Internationales Wageningen University and Research [Wageningen] International Center for Agricultural Research in the Dry Areas University of Oxford

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Résumé : How scientists might better contribute to SDGs in the land sector? At the invitation of INRAE, a group of high-level international experts delivers a comprehensive and systemic approach.

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Fichiers liés : Rapport processus Royaumont (17 03)-CC-BY.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Jean-Frédéric BlancFaiza KhemissaJean-Pierre BronowickiCarole MonterymardJean-Marc PerarnauVincent BourgeoisStéphane ObledMeher Ben AbdelghaniIsabelle Mabile-ArchambeaudRoger FarouxJean-François SeitzChristophe LocherHélène SenellartAnne-Laure VillingFranck AudemarCharlotte CostentinGaël DeplanqueSylvain ManfrediJulien EdelineEvelyne BoucherMarie TalarminSamuel Le SourdJulien VergniolAlice GagnaireLaurent BedenneJean-Louis JouvePatrick HillonCôme LepageAnne MinelloHélène BarraudThierry LecomteJean-Pierre BarbieuxPatrice WolffValérie PhoutthasangChristine BelletierIsabelle ArchambeaudTamara Matysiak BudnikMatthieu SchneeMuriel DulucEmmanuelle Norguet MonnereauJaafar BennounaSandrine HiretMichel GatineauMohamed RamdaniYann Le BricquirNathalie Ganne-CarrieValérie BourcierChristophe PiletteBarbara DauvoisMathieu BaconnierPierre MichelPhilippe ThevenetHélène Cosme-GassmannFrançois HabersetzerCamélia ColtescuMathieu PauwelsSophie Nahon BrissonneauJoëlle EgreteauJérôme DesrameDominique AubyPatrick TexereauPierre-Luc EtienneLouis-Marie DourtheYoussef Tazi
• Organismes : Centre Paul Strauss
• Publié dans Hepatology international le 02/11/2020

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Fichiers liés : PDF Datastream.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Estanislao BurgosMaria Belen de LucaIsidore DioufLuis HaroElise AlbertChristopher SauvageZhao TaoLuisa BermudezRamon AsísAdriano NesiMichel MatringeClaire BréhélinThomas GuiraudCarine FerrandIsabelle AtienzaJoana JorlyJean-Philippe MauxionPierre BaldetAlisdair FernieLeandro QuadranaChristophe RothanMathilde CausseFernando Carrari
• Organismes : Instituto de Fisiología, Biología Molecular y Neurociencias [Buenos Aires] Instituto de Fisiología, Biología Molecular y Neurociencias [Buenos Aires] Génétique et Amélioration des Fruits et Légumes Instituto de Fisiología, Biología Molecular y Neurociencias [Buenos Aires] Michigan State University System Syngenta France Génétique et Amélioration des Fruits et Légumes Instituto Nacional de Tecnología Agropecuaria Centro de Investigaciones en Bioquímica Clínica e Inmunología [Córdoba] Universidade Federal de Viçosa [Brasil] = Federal University of Viçosa [Brazil] = Université fédérale de Viçosa [Brésil] Physiologie cellulaire et végétale Physiologie cellulaire et végétale Biologie du fruit et pathologie Biologie du fruit et pathologie Biologie du fruit et pathologie Biologie du fruit et pathologie Biologie du fruit et pathologie Biologie du fruit et pathologie Max-Planck-Institut Institut de biologie de l'ENS Paris Biologie du fruit et pathologie Génétique et Amélioration des Fruits et Légumes Instituto de Fisiología, Biología Molecular y Neurociencias [Buenos Aires]
• Publié dans The Plant Journal le 26/10/2020

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Résumé : Tocochromanols constitute the different forms of vitamin E (VTE), essential components of the human diet, and display a high membrane protectant activity. By combining interval mapping and genome-wide association studies (GWAS), we unveiled the genetic determinants of tocochromanol accumulation in tomato (Solanum lycopersicum) fruits. To enhance the nutritional value of this highly consumed vegetable, we dissected the natural intraspecific variability of tocochromanols in tomato fruits and genetically engineered their biosynthetic pathway. These analyses allowed the identification of a total of 25 quantitative trait loci interspersed across the genome pinpointing the chorismate-tyrosine pathway as a regulatory hub controlling the supply of the aromatic head group for tocochromanol biosynthesis. To validate the link between the chorismate-tyrosine pathway and VTE, we engineered tomato plants to bypass the pathway at the arogenate branch point. Transgenic tomatoes showed moderate increments in tocopherols (up to approximately 20%) and a massive accumulation of tocotrienols (up to approximately 3400%). Gene expression analyses of these plants reveal a trade-off between VTE and natural variation in chorismate metabolism explained by transcriptional reprogramming of specific structural genes of the pathway. By restoring the accumulation of alpha-tocotrienols (alpha-t3) in fruits, the plants produced here are of high pharmacological and nutritional interest.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Solène HebertPierre ClavelBenjamin MaierKatsuhiro MizutaniFrançois DelvoyeBertrand LapergueMalek Ben MaachaRobert FahedSimon EscalardJean-Philippe DesillesHocine RedjemGabriele CiccioStanislas SmajdaBenjamin GorySébastien RichardRaphaël BlancMichel P. PiotinMikaël Mazighi
• Organismes : Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Laboratoire de Recherche Vasculaire Translationnelle Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Laboratoire de Recherche Vasculaire Translationnelle Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Imagerie Adaptative Diagnostique et Interventionnelle Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Service de neurologie [CHRU Nancy] Laboratoire de Recherche Vasculaire Translationnelle Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Laboratoire de Recherche Vasculaire Translationnelle Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Laboratoire de Recherche Vasculaire Translationnelle Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP]
• Publié dans Journal of Stroke and Cerebrovascular Diseases le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Pierre SenersCyril DargazanliMichel P. PiotinDenis SablotSerge BracardPhilippe NiclotJean-Claude BaronGeorgios Tsivgoulis
• Organismes : Institut de psychiatrie et neurosciences de Paris FHU NeuroVasc [Site Sainte-Anne, Paris] Centre Hospitalier Régional Universitaire [Montpellier] Fondation Ophtalmologique Adolphe de Rothschild [Paris] Centre Hospitalier Saint Jean de Perpignan Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier René Dubos [Pontoise] Institut de psychiatrie et neurosciences de Paris FHU NeuroVasc [Site Sainte-Anne, Paris] Institut de psychiatrie et neurosciences de Paris FHU NeuroVasc [Site Sainte-Anne, Paris]
• Publié dans Stroke le 31/10/2020

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Résumé : Background and Purpose: Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with basilar artery occlusion remains uncertain. Methods: Multicentric retrospective observational study of consecutive minor stroke patients (National Institutes of Health Stroke Scale score ≤5) with basilar artery occlusion intended for IVT alone or bridging therapy. Propensity-score weighting was used to reduce baseline between-groups differences, and residual imbalance was addressed through adjusted logistic regression, with excellent outcome (3-month modified Rankin Scale score 0–1) as the dependent variable. Results: Fifty-seven patients were included (28 and 29 in the bridging therapy and IVT alone groups, respectively). Following propensity-score weighting, the distribution of baseline clinical and radiological variables was similar across the 2 patient groups, except age, posterior circulation Alberta Stroke Program Early CT Score, history of hypertension and smoking, and onset-to-IVT time. Compared with IVT alone, bridging therapy was associated with excellent outcome (adjusted odds ratio=3.37 [95% CI, 1.13–10.03]; P =0.03). No patient experienced symptomatic intracranial hemorrhage. Conclusions: Our results suggest that bridging therapy may be superior to IVT alone in minor stroke with basilar artery occlusion.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Dominique FabreJustine MouginDelphine MitilianFrederic CochennecCarlos Garcia AlonsoJean-Pierre BecqueminPascal DesgrangesEric AllaireSarah HamdiPhilippe BrenotRiyad BourkaibStephan Haulon
• Organismes : Hypertension pulmonaire : physiopathologie et innovation thérapeutique Hypertension pulmonaire : physiopathologie et innovation thérapeutique Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 Hypertension pulmonaire : physiopathologie et innovation thérapeutique IMRB - SMCD/"Senescence, Metabolism and Cardiovascular Diseases" [Créteil] Service de chirurgie thoracique et cardio-vasculaire [Mondor] IMRB - SMCD/"Senescence, Metabolism and Cardiovascular Diseases" [Créteil] Clinique Geoffroy Saint-Hilaire Groupe Hospitalier Intercommunal Le Raincy-Montfermeil Hôpital Marie-Lannelongue Hôpital Marie-Lannelongue Centre hospitalier Saint-Joseph [Paris] Université Paris-Saclay Hypertension pulmonaire : physiopathologie et innovation thérapeutique
• Publié dans European Journal of Vascular and Endovascular Surgery le 22/10/2020

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Fichiers liés : S1078588420310492.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/01/2021
• Auteurs : Thomas W.L. ScheerenJan BakkerThomas KaufmannDjillali AnnanePierre AsfarEvert Christiaan BoermaMaurizio CecconiMichelle S. ChewBernard CholleyMaria B. CronhjortDaniel P. de BackerArnaldo DubinMartin W. DünserJacques DuranteauAnthony C. GordonLudhmila Hajjar HajjarOlfa HamzaouiGlenn P. HernandezVanina Siham Kanoore EdulGeert KosterGiovanni LandoniMarc LeoneBruno LevyClaude MartinAlexandre MebazaaXavier MonnetAndrea MorelliDidier M. PayenRupert M. PearseMichael R. PinskyPeter L. RadermacherDaniel Arnulf ReuterYasser L. SakrMichael SanderBernd SaugelMervyn SingerPierre Alexandre SquaraAntoine Vieillard-BaronPhilippe VignonJean Louis VincentIwan C.C. van Der HorstSimon Tilma VistisenJean Louis Teboul
• Organismes : University of Groningen [Groningen] University Medical Center Groningen [Groningen] New York University Langone Medical Center Columbia University Medical Center Erasmus University Medical Center [Rotterdam] University of Groningen [Groningen] Hôpital Raymond Poincaré [AP-HP] UFR Sciences de la santé Simone Veil Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Medical Centre Leeuwarden Istituto Clinico Humanitas [Milan] Humanitas University [Milan] Linköping University Hôpital Européen Georges Pompidou [APHP] UFR Médecine [Santé] - Université Paris Cité Karolinska Institutet [Stockholm] Centre Hospitalier Interrégional Edith Cavell Universidad Nacional de la Plata [Buenos Aires] University of Linz - Johannes Kepler Universität Linz Kepler University Hospital UFR Sciences de la santé Simone Veil Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Imperial College London Universidade de São Paulo = University of São Paulo AP-HP - Hôpital Antoine Béclère [Clamart] Pontificia Universidad Católica de Chile = Pontifical Catholic University of Chile [Santiago] Hospital Juan A. Fernandez [Buenos Aires, Argentina] University Medical Center Groningen [Groningen] Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] Hôpital Nord [CHU - APHM] Défaillance Cardiovasculaire Aiguë et Chronique Hôpital Nord [CHU - APHM] Département d’Anesthésie-Réanimation-SMUR [Hôpital Lariboisière] Centre de Référence de l’Hypertension Pulmonaire Sévère [CHU Le Kremlin Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Ecotaxie, microenvironnement et développement lymphocytaire Hôpital Lariboisière-Fernand-Widal [APHP] William Harvey Research Institute, Barts and the London Medical School Queen Mary University of London University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] Universitätsklinikum Ulm - University Hospital of Ulm University Medical Center Rostock Universitätsklinikum Jena = Jena University Hospital [Jena, Germany] Justus-Liebig-Universität Gießen = Justus Liebig University Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] University College London [UCL] Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Centre de recherche en épidémiologie et santé des populations Centre d'Investigation Clinique de Limoges Université libre de Bruxelles = Free University of Brussels Maastricht University Medical Centre Aarhus University Hospital Centre de Référence de l’Hypertension Pulmonaire Sévère [CHU Le Kremlin Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Background: Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope therapy in the treatment of patients with circulatory shock. Methods: From November 2016 to April 2017, an anonymous web-based survey on the use of cardiovascular drugs was accessible to members of the European Society of Intensive Care Medicine (ESICM). A total of 14 questions focused on the profile of respondents, the triggering factors, first-line choice, dosing, timing, targets, additional treatment strategy, and suggested effect of inotropes. In addition, a group of 42 international ESICM experts was asked to formulate recommendations for the use of inotropes based on 11 questions. Results: A total of 839 physicians from 82 countries responded. Dobutamine was the first-line inotrope in critically ill patients with acute heart failure for 84% of respondents. Two-thirds of respondents (66%) stated to use inotropes when there were persistent clinical signs of hypoperfusion or persistent hyperlactatemia despite a supposed adequate use of fluids and vasopressors, with (44%) or without (22%) the context of low left ventricular ejection fraction. Nearly half (44%) of respondents stated an adequate cardiac output as target for inotropic treatment. The experts agreed on 11 strong recommendations, all of which were based on excellent (> 90%) or good (81–90%) agreement. Recommendations include the indications for inotropes (septic and cardiogenic shock), the choice of drugs (dobutamine, not dopamine), the triggers (low cardiac output and clinical signs of hypoperfusion) and targets (adequate cardiac output) and stopping criteria (adverse effects and clinical improvement). Conclusion: Inotrope use in critically ill patients is quite heterogeneous as self-reported by individual caregivers. Eleven strong recommendations on the indications, choice, triggers and targets for the use of inotropes are given by international experts. Future studies should focus on consistent indications for inotrope use and implementation into a guideline for circulatory shock that encompasses individualized targets and outcomes.

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Fichiers liés : 13613_2021_Article_806.pdf

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