Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 07/02/2021
• Auteurs : Florent ColinKristine SchauerAli HamichePierre MartineauJean-Paul BorgJan BednarGiulia BertolinLuc CamoinY. ColletteStephan DimitrovIsabelle FournierVincent HyenneMarco Antonio Mendoza-ParraXavier MorelliPhilippe RondéIzabela SumaraMarc TramierPatrick SchultzJacky G. Goetz
• Organismes : Immuno-Rhumatologie Moléculaire Biologie Cellulaire et Cancer Dynamique des cellules tumorales Institut de Génétique et de Biologie Moléculaire et Cellulaire Institut de Recherche en Cancérologie de Montpellier Centre de Recherche en Cancérologie de Marseille Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Institut de Génétique et Développement de Rennes Centre de Recherche en Cancérologie de Marseille Centre de Recherche en Cancérologie de Marseille Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 Immuno-Rhumatologie Moléculaire Génomique métabolique Centre de Recherche en Cancérologie de Marseille Genoscope - Centre national de séquençage [Evry] Laboratoire de Bioimagerie et Pathologies Institut de Génétique et de Biologie Moléculaire et Cellulaire Institut de Génétique et Développement de Rennes Institut de Génétique et de Biologie Moléculaire et Cellulaire Immuno-Rhumatologie Moléculaire
• Publié dans Biology of the Cell le 28/10/2020

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Résumé : Cancer is a multi-step disease where an initial tumour progresses through critical steps shaping, in most cases, life-threatening secondary foci called metastases. The oncogenic cascade involves genetic, epigenetic, signalling pathways, intracellular trafficking and/or metabolic alterations within cancer cells. In addition, pre-malignant and malignant cells orchestrate complex and dynamic interactions with non-malignant cells and acellular matricial components or secreted factors within the tumour microenvironment that is instrumental in the progression of the disease. As our aptitude to effectively treat cancer mostly depends on our ability to decipher, properly diagnose and impede cancer progression and metastasis formation, full characterisation of molecular complexes and cellular processes at play along the metastasis cascade is crucial. For many years, the scientific community lacked adapted imaging and molecular technologies to accurately dissect, at the highest resolution possible, tumour and stromal cells behaviour within their natural microenvironment. In that context, the NANOTUMOR consortium is a French national multi-disciplinary workforce which aims at a providing a multi-scale characterisation of the oncogenic cascade, from the atomic level to the dynamic organisation of the cell in response to genetic mutations, environmental changes or epigenetic modifications. Ultimately, this program aims at identifying new therapeutic targets using innovative drug design.

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Fichiers liés : Colin et al-2021-The NANOTUMOR consortium - towards the Tumor Cell Atlas.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/02/2021
• Auteurs : Ming WangMaria Dolores Perez-GarciaJean-Michel DavièreFrançois BarbierLaurent OgéJosé GentilhommeLinda VoisineThomas PéronAlexandra Launay-AvonGilles ClémentNicolas BaumbergerSandrine BalzergueDavid MacherelPhilippe GrappinJessica BerthelootPatrick AchardLatifa HamamaSoulaiman Sakr
• Organismes : Qingdao Agricultural University Qingdao Institut Agro Rennes Angers Université d'Angers Institut de Biologie Moléculaire des Plantes Institut Agro Rennes Angers Institut Agro Rennes Angers Institut Agro Rennes Angers Institut Agro Rennes Angers Institut Agro Rennes Angers Institut des Sciences des Plantes de Paris-Saclay Institut Jean-Pierre Bourgin - Sciences du végétal Institut de Biologie Moléculaire des Plantes Institut Agro Rennes Angers Institut Agro Rennes Angers Institut Agro Rennes Angers Institut Agro Rennes Angers Institut de Biologie Moléculaire des Plantes Institut Agro Rennes Angers Institut Agro Rennes Angers
• Publié dans Journal of Experimental Botany le 25/10/2020

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Résumé : Shoot branching is a pivotal process during plant growth and development, antagonistically orchestrated by auxin and sugars. By contrast to extensive investigations on hormonal regulatory networks, our current knowledge on the role of sugar signalling pathways in bud outgrowth is still scarce. Based on a stepwise and comprehensive strategy, we investigated the role of glycolysis/the tricarboxylic acid (TCA) cycle and the oxidative pentose phosphate pathway (OPPP) in the control of bud outgrowth. We demonstrated that these two pathways are necessary for bud outgrowth promotion upon plant decapitation and in response to sugar availability. They are also targets of the antagonistic crosstalk between auxin and sugar availability. These two pathways act synergistically to downregulate the expression of BRC1, a conserved inhibitor of shoot branching. Using Rosa calluses stably transformed with GFP-fused promoter sequences of RhBRC1 (pRhBRC1), glycolysis/TCA-cycle and the OPPP were found to repress the transcriptional activity of pRhBRC1 cooperatively. Glycolysis/TCA-cycle- and OPPP-dependent regulations involve the -1973bp/-1611bp and -1206bp/-709bp regions of pRhBRC1, respectively. Taken together, our findings indicate that glycolysis/the tricarboxylic acid cycle and the OPPP are integrative parts of shoot branching control and can link endogenous factors to the developmental program of bud outgrowth, more likely through two distinct mechanisms.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/02/2021
• Auteurs : Alexandre de Saint GermainAnse JacobsGuillaume BrunJean-Bernard PouvreauLukas BraemDavid CornuGuillaume ClavéEmmanuelle BauduVincent SteinmetzVincent ServajeanSusann WickeKris GevaertP SimierSofie GoormachtigP DelavaultFrançois-Didier Boyer
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics Laboratoire de Physiologie et Biotechnologies Végétales Laboratoire de biologie et pathologie végétales Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics Institut de Biologie Intégrative de la Cellule Institut de Chimie des Substances Naturelles Institut Jean-Pierre Bourgin - Sciences du végétal Institut de Chimie des Substances Naturelles Institut de Chimie des Substances Naturelles Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Department of Biomolecular Medicine Laboratoire de biologie et pathologie végétales Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics Laboratoire de biologie et pathologie végétales Institut de Chimie des Substances Naturelles
• Publié dans Plant Communications le 29/07/2020

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Résumé : Phelipanche ramosa is an obligate root-parasitic weed that threatens major crops in central Europe. In order to germinate, it must perceive various structurally divergent host-exuded signals, including isothiocyanates (ITCs) and strigolactones (SLs). However, the receptors involved are still uncharacterized. Here, we identify five putative SL receptors in P. ramosa and show that PrKAI2d3 is involved in the stimulation of seed germination. We demonstrate the high plasticity of PrKAI2d3, which allows it to interact with different chemicals, including ITCs. The SL perception mechanism of PrKAI2d3 is similar to that of endogenous SLs in non-parasitic plants. We provide evidence that PrKAI2d3 enzymatic activity confers hypersensitivity to SLs. Additionally, we demonstrate that methylbutenolide-OH binds PrKAI2d3 and stimulates P. ramosa germination with bioactivity comparable to that of ITCs. This study demonstrates that P. ramosa has extended its signal perception system during evolution, a fact that should be considered for the development of specific and efficient biocontrol methods.

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Fichiers liés : de Saint Germai-2021-A Phelipanche ramosa KAI2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/02/2021
• Auteurs : Tangui BarreTeresa Rojas RojasKarine LacombeCamelia ProtopopescuIsabelle Poizot-MartinMarie NishimweDavid ZucmanLaure EsterleEric BillaudHugues AumaitreOlivier BouchaudDavid ReyLionel PirothDominique Salmon-CéronLinda WittkopPhilippe SogniPatrizia M. CarrieriLawrence SerfatyFabienne Marcellin
• Organismes : Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] Hôpital Sainte-Marguerite [CHU - APHM] CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Hôpital Sainte-Marguerite [CHU - APHM] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] Hôpital Foch [Suresnes] Team MORPH3EUS Hôtel-Dieu de Nantes Centre régional de coordination pour la lutte contre le VIH [Nantes] Centre Hospitalier Saint Jean de Perpignan Hôpital Avicenne [AP-HP] Laboratoire éducations et promotion de la santé Hôpitaux Universitaires de Strasbourg CHU Dijon Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Hôpital Cochin [AP-HP] Université Paris Descartes - Paris 5 Team MORPH3EUS Centre Hospitalier Universitaire de Bordeaux Université Paris Descartes - Paris 5 Physiopathologie du système immunitaire Hôpital Cochin [AP-HP] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] Hôpital de Hautepierre [Strasbourg] Hôpitaux Universitaires de Strasbourg Centre de Recherche Saint-Antoine Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille]
• Publié dans Expert Review of Anti-infective Therapy le 28/10/2020

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Résumé : Background: Cannabis use and elevated fatty liver index (FLI≥ 60) (a biomarker of hepatic steatosis in the general population) have been identified as predictors of HCV-related and overall mortality, respectively, in HIV-HCV co-infected patients. However, the relationship between cannabis use and the risk of elevated FLI has never been explored. Methods: Using five-year follow-up data from 997 HIV-HCV co-infected patients (ANRS CO13 HEPAVIH cohort), we analyzed the relationship between cannabis use and FLI using mixed-effects multivariable logistic (outcome: elevated FLI yes/no) and linear (outcome: continuous FLI) regression models. Results: At the last follow-up visit, 27.4% of patients reported regular or daily cannabis use and 27.8% had elevated FLI. After multivariable adjustment, regular or daily cannabis use was associated with a 55% lower risk of elevated FLI (adjusted odds ratio [95% confidence interval]: 0.45 [0.22; 0.94]; p = 0.033) and lower FLI values (adjusted model coefficient: -4.24 [-6.57; -1.91], p<0.0001). Conclusions: Cannabis use is associated with a reduced risk of elevated fatty liver index in HIV-HCV co-infected patients. Further research is needed to confirm whether and how cannabinoids may inhibit the development of hepatic steatosis or other metabolic disorders in high-risk populations.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Ewan TrégarotCatry ThibaultAuréa PottierEl‐hacen M El‐hacenMohamed Ahmed Sidi CheikhCindy CornetJean‐philippe MaréchalPierre Failler
• Organismes : University of the Azores UMR 228 Espace-Dev, Espace pour le développement Savoirs, ENvironnement et Sociétés UMR 228 Espace-Dev, Espace pour le développement University of Portsmouth
• Publié dans Ecosphere le 01/11/2020

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Résumé : Marine coastal ecosystems are crucial to human populations in reducing disaster risk. Least Developed Countries are particularly vulnerable to the effects of climate change, such as sea-level rise and storm surges. The Mauritanian coast, West Africa, ranks among the most vulnerable worldwide to sealevel rise, and coastal communities in the National Park of Banc d'Arguin (PNBA) are particularly at risk. Here, we assessed the service of coastal protection in PNBA by (1) mapping the coastal marine ecosystems with Sentinel-2 imagery and determining their spatial wave height attenuation rates; (2) assessing the vulnerability of villages and natural habitats to coastal hazard risk; and (3) assessing the applicability of coastal protection measures in the PNBA. We found that a total of 83% of the populated coastline presents a moderate to high risk of flooding and erosion, with Iwik and R'Gueiba being the most threatened villages in the PNBA. As for the ecological risk, two low-elevated islands, which support breeding colonies of birds, are particularly vulnerable to sea-level rise. However, in other areas, the rupture in the dune cord created new lagoons that present valuable ecological and economic interests like the Lagoon of Bellaat. Improving the comprehension of wave attenuation provided by coastal habitats, combined with identifying the vulnerability and applicability of coastal protection measures, is essential for achieving the Sendai Framework for Disaster Risk Reduction goals. In the PNBA, relocation of identified villages at risk is probably the best cost-effective solution with the least disturbance to both breeding and wintering birds. Protection of coastal ecosystems will also ensure a continued provision of other ecosystem services, including food supply for sea dependent populations, and contribute to achieving the Paris Agreement and Sustainable Development Goals.

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Fichiers liés : 010081086.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Aurélien MassireCharlotte SeilerThomas TroalenOlivier M. GirardPierre LehmannGilles BrunAxel BartoliBertrand AudoinFabrice BartolomeiJean PelletierVirginie CallotTobias KoberJean‐philippe RanjevaMaxime Guye
• Organismes : Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Institut de Neurosciences des Systèmes Aix Marseille Université Assistance Publique - Hôpitaux de Marseille Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Centre de résonance magnétique biologique et médicale Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM]
• Publié dans Investigative Radiology le 31/10/2020

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Fichiers liés : 2020_FLAWS_A.Massire_T1_HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Jade GhosnHendy AbdoulSoraya FellahiAudrey MerletDominique Salmon-CéronJean-Pierre MoriniJean DeleuzeJacques BlacherJacqueline CapeauJean-Philippe BastardJean-Paul Viard
• Organismes : Sorbonne Université Sorbonne Université Sorbonne Université
• Publié dans AIDS Research and Human Retroviruses le 26/10/2020

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Résumé : People living with HIV (PLWH) are at risk of noninfectious comorbidities. It is important to individualize those at higher risk. In a single-center cohort of PLWH, we performed a cross-sectional analysis of comorbidities, diagnosed according to standard procedures. The primary endpoint was the prevalence of subclinical carotid/coronary atherosclerosis. Secondary endpoints were its association with selected inflammatory/immune activation biomarkers and with other comorbidities. Associations were examined by using Chi-square or Fisher's exact test for categorical variables and Student or Wilcoxon tests for quantitative variables, and a stepwise multivariate logistical model was performed for further exploration. Among 790 participants [median age: 49.8 years (interquartile range, IQR: 44.5-55.6), 77.1% males, median CD4: 536/mm3 (IQR: 390-754), 83.6% with undetectable viral load], asymptomatic atherosclerosis was found in 26% and was associated in multivariate analysis with older age, longer known duration of infection, higher sCD14, and lower adiponectin levels. Hypertension was found in 33.5% of participants, diabetes in 19.4%, renal impairment in 14.6%, elevated low-density lipoprotein-cholesterol in 13.3%, elevated triglyceride/high-density lipoprotein (HDL)-cholesterol ratio in 6.6%, and osteoporosis in 7.9%. The presence of two or more comorbidities was found in 42.1% of participants and was associated in multivariate analysis with older age and longer exposure to antiretrovirals. Comorbidities were diversely associated with biomarkers: osteoporosis with higher IL-6, renal impairment with higher sCD14, hypertension with higher D-dimer, diabetes and elevated triglyceride/HDL-cholesterol ratio both with lower adiponectin and lower 25-hydroxyvitamin D. Asymptomatic atherosclerosis and multimorbidity were frequent in a cohort of middle-aged, well-controlled, PLWH and were associated with traditional and HIV-specific factors. Associations between morbidities and inflammatory/immune activation biomarkers were diverse.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Thomas CuissetLaurent FauchierPierre DeharoAriel CohenVictor WaldmannAbdeslam BouzemanGuillaume DuthoitLinda KoutbiFrancis BessiereFabien LabombardaChristelle MarquiéJean-Baptiste GourraudPierre MondolyJean Marc SellalPierre BordacharAlexis HermidaFrédéric AnselmeAnouk AsselinCaroline AudinetYvette BernardSerge BovedaPaul BruSok Sithikun BunGael ClericiAntoine da CostaMaxime de GuillebonPascal DefayeNathalie ElbazRomain EschalierRodrigue GarciaCharles GuenanciaBenoit Guy-MoyatFranck HalimiDidier IrlesLaurence IserinFrançois JourdaMagalie LadouceurPhilippe LagrangeMikael LaredoJacques MansouratiGrégoire MassouliéAmel MathironPhilippe MauryAnne MessaliKumar NarayananCédric NguyenSandro NinniMarie-Cécile PerierBertrand PierrePenelope PujadasFrédéric SacherPascal SagnolArdalan SharifzadehganCamille WaltonPierre WinumCyril ZakineRaphaël P MartinsJean-Luc PasquiéJean Benoit ThamboXavier JouvenNicolas CombesEloi MarijonFabien SquaraGuillaume TheodoreDidier ScarlattiJérome HourdainJean-Claude DeharoPierre OllitraultPaul MilliezLaure Champ-RigotHugues BaderCécile DuplantierAntoine MilhemAudrey SagnardGéraldine BertauxGabriel LaurentMarc BadozAgustin BortoneGuillaume LaborieAnne RollinQuentin Voglimacci StephanopoliFranck MandelAlexandre DuparcGuillaume DomainJean-Paul AlbenqueChristèle CardinStéphane CombesNikita TaneseKarim HasniChristophe LeclercqVincent GalandDominique PavinPhilippe MaboNathalie BeharNicolas ClementyChristophe LooseAkli OtmaniSandrine VenierAdrien CarabelliPeggy JaconMouna Ben KilaniJean Bapstist GuichardCécile Romeyer-BouchardLaurianne Le GloanVincent ProbstLuc FreyszHugues BlangyChristian de ChillouNicolas SadoulPierre KhattarCharlotte PotelleFrederic JeanPaul PuieZiad KhoueiryPhilippe ChevallierArnaud DulacSylvie Di FilippoKevin GardeyPierre FreyChrystelle AkretAntoine DompnierCarole MaupainXavier WaintraubFrançoise Hidden-LucetThomas ChastreEstelle GandjbakhchNicolas BadencoFabrice ExtramianaAntoine LeenhardtAmir ZouaghiVincent AlgalarrondoDenis AmetEmilie VarletTej ChalbiaSéverine PhilibertJacky OllitraultThomas LavergnePierre BaudinaudAdrian MiroloArnaud SavouréBénédicte GodinCathy BertrandPierre FiorelloNicolas JohnsonPierre-Marc LallemandAlexis HermindaJean-Sylvain HermidaBruno DegandRim El BouazzaouStéphane MourotSamuel GoussotGaël JauvertArnaud LazarusCaroline GrimardChristine AlonsoAlexandre ZhaoOlivier P ThomasBruno CauchemezGhassan MoubarakNicolas LelloucheDavid HamonBogdan EnacheGabriel LactuFrançoise WiartOlivier GeoffroyDamien PoindronAlice MaltretCristine RaimondoDamien BonnetSébastien HascoëtNicolas DervalMichel HaïssaguerreMélèze HociniMarco ProiettiDavid FitzmauriceCécile LarocheFrancisco MarinMichael NabauerTatjana PotparaGheorghe-Andrei DanZbigniew KalarusLuigi TavazziAldo MaggioniGiuseppe Boriani
• Organismes : Hôpital de la Timone [CHU - APHM] Nutrition, obésité et risque thrombotique CHU Trousseau [Tours] Éducation Éthique Santé Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research CHU Saint-Antoine [AP-HP] Université Paris Cité Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Paris-Centre de Recherche Cardiovasculaire Centre Hospitalier de Versailles André Mignot CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Département de Cardiologie [Hôpital de la Timone - APHM] Hôpital Louis Pradel [CHU - HCL] Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardique CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service Cardiologie [CHU Toulouse] Centre Hospitalier Régional Universitaire de Nancy IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] CHU Amiens-Picardie Service de Cardiologie [CHU Rouen] Paris-Centre de Recherche Cardiovasculaire Groupe Hospitalier Bretagne Sud Centre Hospitalier Régional Universitaire de Besançon Clinique Pasteur [Toulouse] Service de cardiologie Hôpital Pasteur [Nice] CHU Saint-Pierre CHU Montpellier = Montpellier University Hospital Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Università degli Studi di Milano = University of Milan Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico University of Liverpool University of Liverpool Aalborg University EURObservational Research Programme, European Society of Cardiology Universidad de Murcia = University of Murcia University of Belgrade [Belgrade] Spitalul Clinic Colentina = Colentina Hospital [Bucharest, Romania] University of Medicine and Pharmacy “Carol Davila” Silesian Medical University, Katowice, Poland Maria Cecilia Hospital Associazione Nazionale Medici Cardiologi Ospedalieri [Firenze] Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
• Publié dans EP-Europace le 30/10/2020

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Résumé : Abstract Aims There has been an increasing focus on integrated, multidisciplinary, and holistic care in the treatment of atrial fibrillation (AF). The ‘Atrial Fibrillation Better Care’ (ABC) pathway has been proposed to streamline integrated care in AF. We evaluated the impact on outcomes of an ABC adherent management in a contemporary real-life European-wide AF cohort. Methods and results Patients enrolled in the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry with baseline data to evaluate ABC criteria and available follow-up data were considered for this analysis. Among the original 11 096 AF patients enrolled, 6646 (59.9%) were included in this analysis, of which 1996 (30.0%) managed as ABC adherent. Patients adherent to ABC care had lower CHA2DS2-VASc and HAS-BLED scores (mean ± SD, 2.68 ± 1.57 vs. 3.07 ± 1.90 and 1.26 ± 0.93 vs. 1.58 ± 1.12, respectively; P < 0.001). At 1-year follow-up, patients managed adherent to ABC pathway compared to non-adherent ones had a lower rate of any thromboembolic event (TE)/acute coronary syndrome (ACS)/cardiovascular (CV) death (3.8% vs. 7.6%), CV death (1.9% vs. 4.8%), and all-cause death (3.0% vs. 6.4%) (all P < 0.0001). On Cox multivariable regression analysis, ABC adherent care showed an association with a lower risk of any TE/ACS/CV death [hazard ratio (HR): 0.59, 95% confidence interval (CI): 0.44–0.79], CV death (HR: 0.52, 95% CI: 0.35–0.78), and all-cause death (HR: 0.57, 95% CI: 0.43–0.78). Conclusion In a large contemporary cohort of European AF patients, a clinical management adherent to ABC pathway for integrated care is associated with a significant lower risk for cardiovascular events, CV death, and all-cause death.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Aurélie BichotMickaël LerostyValérie MéchinNicolas BernetJean-Philippe DelgenèsDiana Garcia-Bernet
• Organismes : Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Institut Jean-Pierre Bourgin - Sciences du végétal Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne]
• Publié dans Energy Conversion and Management le 23/10/2020

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Résumé : As a result of increasing demand for alternatives to fossil energy, the agricultural biogas sector is in expansion and lignocellulosic biomass (LCB) represents an interesting renewable feedstock. Nevertheless, due to the recalcitrance and complexity of its structure, deconstructive pretreatments are necessary to render possible biochemical conversions and efficient biomass exploitation. In this work, chemical-free, mild microwave pretreatment was evaluated (through BMP tests) as a method to improve anaerobic biodegradability of two grass biomass of industrial relevance and contrasted parietal content: corn stalks (low parietal content, high soluble content) and miscanthus (high parietal content, low soluble content). BMP tests carried out on raw biomass before pretreatment highlighted the negative correlation of BMP value to lignin and cellulose contents and the positive correlation to soluble and hemicellulose contents.Efficiency of microwave pretreatment under two conditions, open vessel and high pressure (4 bars), with water as unique solvent was tested for tackling recalcitrance and results were compared to conventional heating pretreatment and a control treatment. Solid and liquid phases were separated after pretreatment with the aim to elucidate if microwave treatment had an impact on organic matter solubilisation and/or on the residual solid phase, which could improve the biodegradability of the pretreated solid fraction. To the authors' knowledge, this is the first study to dissociate methane production of the solid phase from that of the liquid phase after microwave pretreatment.Observed BMP values in mesophilic conditions of raw biomass samples were 286 NLCH4/kgVS for corn stalks and 228 NLCH4/kgVS for miscanthus respectively (in agreement with literature). No significant improvement in BMP value nor in CH4 production kinetics were observed following microwave pretreatment, while a harsh chemical pretreatment (10 h soaking in 10% w/w NaOH) allowed 30% increase in BMP value. These results highlight the significant chemical effect -compared to thermal- on the biomass deconstruction and fibers breakdown during chemical-free microwave pretreatment. A synergy microwave-NaOH effect could allow to achieve higher impact on biomass recalcitrance using lower NaOH amounts than chemical treatment alone.

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Fichiers liés : S019689042031270X.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Roger C. WiensSylvestre MauriceScott H. RobinsonAnthony E. NelsonPhilippe CaisPernelle BernardiRaymond T. NewellSam CleggShiv SharmaSteven StormsJonathan DemingDarrel BeckmanAnn M. OllilaOlivier GasnaultRyan B. AndersonYves AndréS. Michael AngelGorka AranaElizabeth AudenPierre BeckJoseph BeckerKarim BenzeraraSylvain BernardOlivier BeyssacLouis BorgesBruno BousquetKerry BoydMichael CaffreyJeffrey CarlsonKepa CastroJorden CelisBaptiste ChideKevin ClarkEdward CloutisElizabeth CordobaAgnès CousinMagdalena DaleLauren DefloresDorothea DelappMuriel DeleuzeMatthew DirmyerChristophe DonnyGilles DromartM. George DuranMiles EganJoan ErvinCécile FabreAmaury FauWoodward FischerOlivier ForniSoren MadsenThierry FouchetReuben FresquezJens FrydenvangDenine GaswayIvair GontijoNicolas MangoldJohn GrotzingerXavier JacobSophie JacquinodJeffrey JohnsonRoberta A. KlisiewiczJose Antonio ManriqueJames LakeNina L LanzaJavier LasernaJérémie LasueStéphane Le MouélicJ. P. MartinezCarey Legett IvRichard LeveilleEric LewinGuillermo Lopez-ReyesR. LorenzJesus Martinez-FriasEric LorignySteven P. LoveBriana LuceroJuan Manuel MadariagaMorten MadsenKevin P. MccabeTimothy McconnochieJustin M. McglownScott M MclennanNoureddine MelikechiPierre-Yves MeslinJohn M. MichelDavid MimounAnupam MisraGilles MontagnacFranck MontmessinValerie MoussetNaomi MurdochHorton NewsomLogan A. OttZachary OusnamerLaurent ParesYann ParotRafal PawluczykC. Glen PetersonP. PilleriP.C. PinetGabriel PontFrançois PouletCheryl ProvostBenjamin QuertierHeather QuinnWilliam RapinJean-Michel ReessAmy H. ReganAdriana L. Reyes-NewellPhilip RomanoClément RoyerFernando RullBenigno SandovalJoseph H. SarraoV. SautterMarcel SchoppersSusanne SchröderDaniel SeitzTerra ShepherdPablo SobronBruno DuboisVishnu SridharMichael ToplisImanol Torre-FdezIan TrettelMark UnderwoodAndres ValdezJacob ValdezDawn VenhausPeter Willis
• Organismes : Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Los Alamos National Laboratory Los Alamos National Laboratory Laboratoire d'Astrophysique de Bordeaux [Pessac] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Los Alamos National Laboratory Los Alamos National Laboratory University of Hawai‘i [Mānoa] Los Alamos National Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Astrogeology Science Center [Flagstaff] Centre National d'Études Spatiales [Toulouse] University of South Carolina [Columbia] Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Los Alamos National Laboratory Institut de Planétologie et d'Astrophysique de Grenoble Los Alamos National Laboratory Institut de minéralogie, de physique des matériaux et de cosmochimie Institut de minéralogie, de physique des matériaux et de cosmochimie Institut de minéralogie, de physique des matériaux et de cosmochimie Los Alamos National Laboratory Centre d'Etudes Lasers Intenses et Applications Los Alamos National Laboratory Los Alamos National Laboratory Jet Propulsion Laboratory Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Institut Supérieur de l'Aéronautique et de l'Espace Jet Propulsion Laboratory University of Winnipeg Jet Propulsion Laboratory Institut de recherche en astrophysique et planétologie Los Alamos National Laboratory Jet Propulsion Laboratory Los Alamos National Laboratory Centre National d'Études Spatiales [Toulouse] Los Alamos National Laboratory Centre National d'Études Spatiales [Toulouse] Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Los Alamos National Laboratory University of Hawai‘i [Mānoa] Jet Propulsion Laboratory GeoRessources Institut de minéralogie, de physique des matériaux et de cosmochimie California Institute of Technology Institut de recherche en astrophysique et planétologie Jet Propulsion Laboratory Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Los Alamos National Laboratory University of Copenhagen = Københavns Universitet Los Alamos National Laboratory Jet Propulsion Laboratory Laboratoire de Planétologie et Géodynamique [UMR 6112] California Institute of Technology Institut de mécanique des fluides de Toulouse Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Los Alamos National Laboratory Universidad de Valladolid [Valladolid] Los Alamos National Laboratory Los Alamos National Laboratory Universidad de Málaga [Málaga] = University of Málaga [Málaga] Institut de recherche en astrophysique et planétologie Laboratoire de Planétologie et Géodynamique [UMR 6112] Los Alamos National Laboratory Los Alamos National Laboratory McGill University = Université McGill [Montréal, Canada] Institut de Planétologie et d'Astrophysique de Grenoble Universidad de Valladolid [Valladolid] Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Centre National d'Études Spatiales [Toulouse] Los Alamos National Laboratory Los Alamos National Laboratory Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Jet Propulsion Laboratory Los Alamos National Laboratory University of Maryland [College Park] Los Alamos National Laboratory State University of New York University of Massachusetts [Lowell] Institut de recherche en astrophysique et planétologie Los Alamos National Laboratory Institut Supérieur de l'Aéronautique et de l'Espace University of Hawai‘i [Mānoa] Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement PLANETO - LATMOS Centre National d'Études Spatiales [Toulouse] Institut Supérieur de l'Aéronautique et de l'Espace The University of New Mexico [Albuquerque] Los Alamos National Laboratory Jet Propulsion Laboratory Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie FiberTech Optica Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie Centre National d'Études Spatiales [Toulouse] Institut d'astrophysique spatiale FiberTech Optica Laboratoire d'Astrophysique de Bordeaux [Pessac] Los Alamos National Laboratory Institut de minéralogie, de physique des matériaux et de cosmochimie Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Los Alamos National Laboratory Los Alamos National Laboratory Jet Propulsion Laboratory Institut d'astrophysique spatiale Universidad de Valladolid [Valladolid] Los Alamos National Laboratory Los Alamos National Laboratory Institut de minéralogie, de physique des matériaux et de cosmochimie Jet Propulsion Laboratory In­sti­tut für Op­ti­sche Sen­sor­sys­te­me Los Alamos National Laboratory Los Alamos National Laboratory Search for Extraterrestrial Intelligence Institute Observatoire Midi-Pyrénées Jet Propulsion Laboratory Institut de recherche en astrophysique et planétologie Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Jet Propulsion Laboratory Jet Propulsion Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Jet Propulsion Laboratory
• Publié dans Space Science Reviews le 31/10/2020

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Résumé : TheSuperCaminstrumentsuiteprovidestheMars2020rover,Perseverance,with a number of versatile remote-sensing techniques that can be used at long distance as well as within the robotic-arm workspace. These include laser-induced breakdown spectroscopy (LIBS), remote time-resolved Raman and luminescence spectroscopies, and visible and in- frared (VISIR; separately referred to as VIS and IR) reflectance spectroscopy. A remote micro-imager (RMI) provides high-resolution color context imaging, and a microphone can be used as a stand-alone tool for environmental studies or to determine physical properties of rocks and soils from shock waves of laser-produced plasmas. SuperCam is built in three parts: The mast unit (MU), consisting of the laser, telescope, RMI, IR spectrometer, and associated electronics, is described in a companion paper. The on-board calibration targets are described in another companion paper. Here we describe SuperCam’s body unit (BU) and testing of the integrated instrument. The BU, mounted inside the rover body, receives light from the MU via a 5.8 m opti- cal fiber. The light is split into three wavelength bands by a demultiplexer, and is routed via fiber bundles to three optical spectrometers, two of which (UV and violet; 245–340 and 385–465 nm) are crossed Czerny-Turner reflection spectrometers, nearly identical to their counterparts on ChemCam. The third is a high-efficiency transmission spectrometer contain- ing an optical intensifier capable of gating exposures to 100 ns or longer, with variable delay times relative to the laser pulse. This spectrometer covers 535–853 nm (105–7070 cm−1 Ra- man shift relative to the 532 nm green laser beam) with 12 cm−1 full-width at half-maximum peak resolution in the Raman fingerprint region. The BU electronics boards interface with the rover and control the instrument, returning data to the rover. Thermal systems maintain a warm temperature during cruise to Mars to avoid contamination on the optics, and cool the detectors during operations on Mars. Results obtained with the integrated instrument demonstrate its capabilities for LIBS, for which a library of 332 standards was developed. Examples of Raman and VISIR spec- troscopy are shown, demonstrating clear mineral identification with both techniques. Lumi- nescence spectra demonstrate the utility of having both spectral and temporal dimensions. Finally, RMI and microphone tests on the rover demonstrate the capabilities of these sub- systems as well.

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Fichiers liés : Wiens2020_Article_TheSuperCamInstrumentSuiteOnTh.pdf

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