Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Rafik TadrosCatherine FrancisXiao XuAlexa VermeerAndrew HarperRoy HuurmanKen Kelu BisabuRoddy WalshEdgar HoorntjeWouter Te RijdtRachel BuchanHannah van VelzenMarjon van SlegtenhorstJentien VermeulenJoost Allard OfferhausWenjia BaiAntonio de MarvaoNajim LahrouchiLeander BeekmanJacco KarperJan H VeldinkElham KayvanpourAntonis PantazisA. John BaksiNicola WhiffinFrancesco MazzarottoGeraldine SloaneHideaki SuzukiDeborah Schneider-LuftmanPaul ElliottPascale RichardF. AderEric VillardPeter LichtnerThomas MeitingerMichael W TanckJ. Peter van TintelenAndrew ThainDavid MccartyRobert HegeleJason RobertsJulie AmyotMarie-Pierre DubéJulia Cadrin-TourignyGeneviève GiraldeauPhilippe L’allierPatrick GarceauJean-Claude TardifS. Matthijs BoekholdtR. Thomas LumbersFolkert W AsselbergsPaul BartonStuart CookSanjay PrasadDeclan O’reganJolanda van Der VeldenKarin VerweijMario TalajicGuillaume LettreYigal PintoBenjamin MederPhilippe CharronRudolf de BoerImke ChristiaansMichelle MichelsArthur WildeHugh WatkinsPaul MatthewsJames WareConnie R Bezzina
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Assistance publique - Hôpitaux de Paris (AP-HP)
• Publié dans Nature Genetics le 29/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Aurélie BichotMickaël LerostyValérie MéchinNicolas BernetJean-Philippe DelgenèsDiana Garcia-Bernet
• Organismes : Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Institut Jean-Pierre Bourgin - Sciences du végétal Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Laboratoire de Biotechnologie de l'Environnement [Narbonne]
• Publié dans Energy Conversion and Management le 23/10/2020

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Résumé : As a result of increasing demand for alternatives to fossil energy, the agricultural biogas sector is in expansion and lignocellulosic biomass (LCB) represents an interesting renewable feedstock. Nevertheless, due to the recalcitrance and complexity of its structure, deconstructive pretreatments are necessary to render possible biochemical conversions and efficient biomass exploitation. In this work, chemical-free, mild microwave pretreatment was evaluated (through BMP tests) as a method to improve anaerobic biodegradability of two grass biomass of industrial relevance and contrasted parietal content: corn stalks (low parietal content, high soluble content) and miscanthus (high parietal content, low soluble content). BMP tests carried out on raw biomass before pretreatment highlighted the negative correlation of BMP value to lignin and cellulose contents and the positive correlation to soluble and hemicellulose contents.Efficiency of microwave pretreatment under two conditions, open vessel and high pressure (4 bars), with water as unique solvent was tested for tackling recalcitrance and results were compared to conventional heating pretreatment and a control treatment. Solid and liquid phases were separated after pretreatment with the aim to elucidate if microwave treatment had an impact on organic matter solubilisation and/or on the residual solid phase, which could improve the biodegradability of the pretreated solid fraction. To the authors' knowledge, this is the first study to dissociate methane production of the solid phase from that of the liquid phase after microwave pretreatment.Observed BMP values in mesophilic conditions of raw biomass samples were 286 NLCH4/kgVS for corn stalks and 228 NLCH4/kgVS for miscanthus respectively (in agreement with literature). No significant improvement in BMP value nor in CH4 production kinetics were observed following microwave pretreatment, while a harsh chemical pretreatment (10 h soaking in 10% w/w NaOH) allowed 30% increase in BMP value. These results highlight the significant chemical effect -compared to thermal- on the biomass deconstruction and fibers breakdown during chemical-free microwave pretreatment. A synergy microwave-NaOH effect could allow to achieve higher impact on biomass recalcitrance using lower NaOH amounts than chemical treatment alone.

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Fichiers liés : S019689042031270X.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Roger C. WiensSylvestre MauriceScott H. RobinsonAnthony E. NelsonPhilippe CaisPernelle BernardiRaymond T. NewellSam CleggShiv SharmaSteven StormsJonathan DemingDarrel BeckmanAnn M. OllilaOlivier GasnaultRyan B. AndersonYves AndréS. Michael AngelGorka AranaElizabeth AudenPierre BeckJoseph BeckerKarim BenzeraraSylvain BernardOlivier BeyssacLouis BorgesBruno BousquetKerry BoydMichael CaffreyJeffrey CarlsonKepa CastroJorden CelisBaptiste ChideKevin ClarkEdward CloutisElizabeth CordobaAgnès CousinMagdalena DaleLauren DefloresDorothea DelappMuriel DeleuzeMatthew DirmyerChristophe DonnyGilles DromartM. George DuranMiles EganJoan ErvinCécile FabreAmaury FauWoodward FischerOlivier ForniSoren MadsenThierry FouchetReuben FresquezJens FrydenvangDenine GaswayIvair GontijoNicolas MangoldJohn GrotzingerXavier JacobSophie JacquinodJeffrey JohnsonRoberta A. KlisiewiczJose Antonio ManriqueJames LakeNina L LanzaJavier LasernaJérémie LasueStéphane Le MouélicJ. P. MartinezCarey Legett IvRichard LeveilleEric LewinGuillermo Lopez-ReyesR. LorenzJesus Martinez-FriasEric LorignySteven P. LoveBriana LuceroJuan Manuel MadariagaMorten MadsenKevin P. MccabeTimothy McconnochieJustin M. McglownScott M MclennanNoureddine MelikechiPierre-Yves MeslinJohn M. MichelDavid MimounAnupam MisraGilles MontagnacFranck MontmessinValerie MoussetNaomi MurdochHorton NewsomLogan A. OttZachary OusnamerLaurent ParesYann ParotRafal PawluczykC. Glen PetersonP. PilleriP.C. PinetGabriel PontFrançois PouletCheryl ProvostBenjamin QuertierHeather QuinnWilliam RapinJean-Michel ReessAmy H. ReganAdriana L. Reyes-NewellPhilip RomanoClément RoyerFernando RullBenigno SandovalJoseph H. SarraoV. SautterMarcel SchoppersSusanne SchröderDaniel SeitzTerra ShepherdPablo SobronBruno DuboisVishnu SridharMichael ToplisImanol Torre-FdezIan TrettelMark UnderwoodAndres ValdezJacob ValdezDawn VenhausPeter Willis
• Organismes : Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Los Alamos National Laboratory Los Alamos National Laboratory Laboratoire d'Astrophysique de Bordeaux [Pessac] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Los Alamos National Laboratory Los Alamos National Laboratory University of Hawai‘i [Mānoa] Los Alamos National Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Astrogeology Science Center [Flagstaff] Centre National d'Études Spatiales [Toulouse] University of South Carolina [Columbia] Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Los Alamos National Laboratory Institut de Planétologie et d'Astrophysique de Grenoble Los Alamos National Laboratory Institut de minéralogie, de physique des matériaux et de cosmochimie Institut de minéralogie, de physique des matériaux et de cosmochimie Institut de minéralogie, de physique des matériaux et de cosmochimie Los Alamos National Laboratory Centre d'Etudes Lasers Intenses et Applications Los Alamos National Laboratory Los Alamos National Laboratory Jet Propulsion Laboratory Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Institut Supérieur de l'Aéronautique et de l'Espace Jet Propulsion Laboratory University of Winnipeg Jet Propulsion Laboratory Institut de recherche en astrophysique et planétologie Los Alamos National Laboratory Jet Propulsion Laboratory Los Alamos National Laboratory Centre National d'Études Spatiales [Toulouse] Los Alamos National Laboratory Centre National d'Études Spatiales [Toulouse] Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Los Alamos National Laboratory University of Hawai‘i [Mānoa] Jet Propulsion Laboratory GeoRessources Institut de minéralogie, de physique des matériaux et de cosmochimie California Institute of Technology Institut de recherche en astrophysique et planétologie Jet Propulsion Laboratory Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Los Alamos National Laboratory University of Copenhagen = Københavns Universitet Los Alamos National Laboratory Jet Propulsion Laboratory Laboratoire de Planétologie et Géodynamique [UMR 6112] California Institute of Technology Institut de mécanique des fluides de Toulouse Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Los Alamos National Laboratory Universidad de Valladolid [Valladolid] Los Alamos National Laboratory Los Alamos National Laboratory Universidad de Málaga [Málaga] = University of Málaga [Málaga] Institut de recherche en astrophysique et planétologie Laboratoire de Planétologie et Géodynamique [UMR 6112] Los Alamos National Laboratory Los Alamos National Laboratory McGill University = Université McGill [Montréal, Canada] Institut de Planétologie et d'Astrophysique de Grenoble Universidad de Valladolid [Valladolid] Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Centre National d'Études Spatiales [Toulouse] Los Alamos National Laboratory Los Alamos National Laboratory Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Jet Propulsion Laboratory Los Alamos National Laboratory University of Maryland [College Park] Los Alamos National Laboratory State University of New York University of Massachusetts [Lowell] Institut de recherche en astrophysique et planétologie Los Alamos National Laboratory Institut Supérieur de l'Aéronautique et de l'Espace University of Hawai‘i [Mānoa] Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement PLANETO - LATMOS Centre National d'Études Spatiales [Toulouse] Institut Supérieur de l'Aéronautique et de l'Espace The University of New Mexico [Albuquerque] Los Alamos National Laboratory Jet Propulsion Laboratory Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie FiberTech Optica Los Alamos National Laboratory Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie Centre National d'Études Spatiales [Toulouse] Institut d'astrophysique spatiale FiberTech Optica Laboratoire d'Astrophysique de Bordeaux [Pessac] Los Alamos National Laboratory Institut de minéralogie, de physique des matériaux et de cosmochimie Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Los Alamos National Laboratory Los Alamos National Laboratory Jet Propulsion Laboratory Institut d'astrophysique spatiale Universidad de Valladolid [Valladolid] Los Alamos National Laboratory Los Alamos National Laboratory Institut de minéralogie, de physique des matériaux et de cosmochimie Jet Propulsion Laboratory In­sti­tut für Op­ti­sche Sen­sor­sys­te­me Los Alamos National Laboratory Los Alamos National Laboratory Search for Extraterrestrial Intelligence Institute Observatoire Midi-Pyrénées Jet Propulsion Laboratory Institut de recherche en astrophysique et planétologie Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] Jet Propulsion Laboratory Jet Propulsion Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Jet Propulsion Laboratory
• Publié dans Space Science Reviews le 31/10/2020

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Résumé : TheSuperCaminstrumentsuiteprovidestheMars2020rover,Perseverance,with a number of versatile remote-sensing techniques that can be used at long distance as well as within the robotic-arm workspace. These include laser-induced breakdown spectroscopy (LIBS), remote time-resolved Raman and luminescence spectroscopies, and visible and in- frared (VISIR; separately referred to as VIS and IR) reflectance spectroscopy. A remote micro-imager (RMI) provides high-resolution color context imaging, and a microphone can be used as a stand-alone tool for environmental studies or to determine physical properties of rocks and soils from shock waves of laser-produced plasmas. SuperCam is built in three parts: The mast unit (MU), consisting of the laser, telescope, RMI, IR spectrometer, and associated electronics, is described in a companion paper. The on-board calibration targets are described in another companion paper. Here we describe SuperCam’s body unit (BU) and testing of the integrated instrument. The BU, mounted inside the rover body, receives light from the MU via a 5.8 m opti- cal fiber. The light is split into three wavelength bands by a demultiplexer, and is routed via fiber bundles to three optical spectrometers, two of which (UV and violet; 245–340 and 385–465 nm) are crossed Czerny-Turner reflection spectrometers, nearly identical to their counterparts on ChemCam. The third is a high-efficiency transmission spectrometer contain- ing an optical intensifier capable of gating exposures to 100 ns or longer, with variable delay times relative to the laser pulse. This spectrometer covers 535–853 nm (105–7070 cm−1 Ra- man shift relative to the 532 nm green laser beam) with 12 cm−1 full-width at half-maximum peak resolution in the Raman fingerprint region. The BU electronics boards interface with the rover and control the instrument, returning data to the rover. Thermal systems maintain a warm temperature during cruise to Mars to avoid contamination on the optics, and cool the detectors during operations on Mars. Results obtained with the integrated instrument demonstrate its capabilities for LIBS, for which a library of 332 standards was developed. Examples of Raman and VISIR spec- troscopy are shown, demonstrating clear mineral identification with both techniques. Lumi- nescence spectra demonstrate the utility of having both spectral and temporal dimensions. Finally, RMI and microphone tests on the rover demonstrate the capabilities of these sub- systems as well.

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Fichiers liés : Wiens2020_Article_TheSuperCamInstrumentSuiteOnTh.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Anne PeskineAlain CariouDavid HajageNicolas DeyeEmmanuel GuérotMartin DresRomain SonnevilleAlexandre LafourcadeVincent NavarroHélène RobertPhilippe AzouviTarek SharsharEleonore BayenCharles-Edouard LuytGuillaume HékimianNicolas BréchotMathieu SchmidtAlain CombesCharles-Edouard LuytAlexandre DemouleMartin DresJulien MayauxAnne PeskineHélène RobertPascale Pradat-DiehlEleonore BayenVincent NavarroDamien GalanaudNathalie MarinJulien CharpentierAlain CariouJean-Paul MiraOlivier VignaudEmmanuel GuérotJean-Luc DiehlJean-Yves FagonNicolas DeyeBruno MégarbaneJean-Pierre GuichardNathalie KubisAlain YelnikRomain SonnevilleLila BouadmaJean-François TimsitIsabelle KleinTarek SharsharPhilippe AzouviRobert CarlierFlorence Colle
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Hôpital Cochin [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Européen Georges Pompidou [APHP] CHU Pitié-Salpêtrière [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Hôpital Raymond Poincaré (Garches) [GHU AP-HP Université Paris-Saclay] Hôpital Sainte-Anne CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière] Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans Chest le 29/10/2020

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Résumé : Background: Long-term outcomes of awakened survivors of out-of-hospital cardiac arrest (OHCA) are poorly known.Research question: What are the month (M) 18 outcomes of survivors of out-of-hospital cardiac arrest (OHCA) who awakened during the first 2 weeks' post-OHCA and their poor-outcome risk factors?Study design and methods: All OHCA survivors with a Glasgow Coma Scale score ≥12 during the first 2 weeks' post-OHCA were enrolled in six ICUs and followed up at M3, M6, M12, and M18. The primary outcome measure was Glasgow Outcome Scale-Extended (GOS-E) score at M18. Secondary outcome measures included evaluation at M18 of neurologic, behavioral, and cognitive disabilities; health-related quality of life (HR-QOL), anxiety and depression; and poor-outcome risk factors (GOS-E score ≤ 6).Results: Among the 139 included patients, 98 were assessable for the primary outcome measure. At M18, 64 (65%) had full recovery or minor disabilities (GOS-E score > 6), 18 (18%) had moderate disabilities but were autonomous for daily-life activities (GOS-E score = 6), 12 (12%) had poor autonomy (GOS-E score < 6 but > 1), and four had died. Percentages of patients with GOS-E scores > 6 increased significantly over the 18-month study period. At M18, no patients had major neurologic disabilities, 20% had cognitive disabilities, 32% had anxiety symptoms, 25% had depression symptoms, and their HR-QOL was impaired compared with a sex- and age-matched population. Low-flow time, Sequential Organ Failure Assessment score at admission, coma duration > 3 days after cardiac arrest, and mechanical ventilation on days 3 and 7 were associated with poor functional outcome.Interpretation: Among patients who awoke (Glasgow Coma Scale score ≥12) in the 14 days following OHCA, 35% had moderate to severe disabilities or had died at M18. Interestingly, patients improved until M18 post-OHCA. Risk factors associated with poor functional outcome were low-flow time, clinical severity at ICU admission, prolonged coma duration, and mechanical ventilation.Clinical trial registration: ClinicalTrials.gov; No.: NCT02292147; URL: www.clinicaltrials.gov.

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Fichiers liés : S0012369220319516.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Giuliana AmaddeoRaffaele BrustiaManon AllaireMarie LequoyClémence HollandeHélène RegnaultLorraine BlaiseNathalie Ganne-CarriéOlivier SérorEdouard LarreyChetana LimOlivier ScattonSanaa El MouhadiViolaine OzenneFrançois PayePierre BalladurAnthony DohanPierre-Philippe MassaultStanislas PolMarco Dioguardi BurgioValérie VilgrainAilton SepulvedaFrancois CauchyAlain LucianiDaniele SommacaleVincent LeroyFrancoise Roudot-ThoravalMohamed BouattourJean-Charles Nault
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de recherche sur l'Inflammation Centre de recherche sur l'Inflammation Centre de recherche sur l'Inflammation Centre de Recherche des Cordeliers
• Publié dans JHEP Reports Innovation in Hepatology le 07/09/2020

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Résumé : Background & Aims: Patients affected by hepatocellular carcinoma (HCC) represent a vulnerable population during the COVID-19 pandemic and may suffer from altered allocation of healthcare resources. The aim of this study was to determine the impact of the COVID-19 pandemic on the management of patients with HCC within 6 referral centres in the metropolitan area of Paris, France. Methods: We performed a multicentre, retrospective, cross-sectional study on the management of patients with HCC during the first 6 weeks of the COVID-19 pandemic (exposed group), compared with the same period in 2019 (unexposed group). We included all patients discussed in multidisciplinary tumour board (MTB) meetings and/or patients undergoing a radiological or surgical programmed procedure during the study period, with curative or palliative intent. Endpoints were the number of patients with a modification in the treatment strategy, or a delay in decision-to-treat. Results: After screening, n = 670 patients were included (n = 293 exposed to COVID, n = 377 unexposed to COVID). Fewer patients with HCC presented to the MTB in 2020 (p = 0.034) and fewer had a first diagnosis of HCC (n = 104 exposed to COVID, n = 143 unexposed to COVID, p = 0.083). Treatment strategy was modified in 13.1% of patients, with no differences between the 2 periods. Nevertheless, 21.5% vs. 9.5% of patients experienced a treatment delay longer than 1 month in 2020 compared with 2019 (p <0.001). In 2020, 7.1% (21/293) of patients had a diagnosis of an active COVID-19 infection: 11 (52.4%) patients were hospitalised and 4 (19.1%) patients died. Conclusions: In a metropolitan area highly impacted by the COVID-19 pandemic, we observed fewer patients with HCC, and similar rates of treatment modification, but with a significantly longer treatment delay in 2020 vs. 2019.

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Fichiers liés : 1-s2.0-S2589555920301336-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Federica RibaldiDaniele AltomareJorge JovicichClarissa FerrariAgnese PiccoFrancesca Benedetta PizziniAndrea SoricelliAnna MegaAntonio FerrettiAntonios DrevelegasBeatriz BoschBernhard MüllerCamillo MarraCarlo CavaliereDavid Bartrés-FazFlavio NobiliFranco AlessandriniFrederik BarkhofHélène Gros-DagnacJean‐philippe RanjevaJens WiltfangJoost KuijerJulien SeinKarl-Titus HoffmannLuca RoccatagliataLucilla ParnettiMagda TsolakiManos ConstantinidisMarco AielloMarco SalvatoreMartina MontaltiMassimo CauloMira DidicNúria BargalloOlivier BlinPaolo RossiniPeter SchonknechtPiero FloridiPierre PayouxPieter Jelle VisserRégis BordetRenaud LopesRoberto TarducciStephanie BomboisTilman HenschUte FiedlerJill RichardsonGiovanni FrisoniMoira Marizzoni
• Organismes : Centro San Giovanni di Dio, Fatebenefratelli, Brescia Laboratory of Neuroimaging of aging, Memory clinic and LANVIE Laboratory of Neuroimaging of aging, Memory clinic and LANVIE Center for Mind/Brain Sciences Centro San Giovanni di Dio, Fatebenefratelli, Brescia Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] Department of Diagnostics and Public Health [Verona] IRCCS SDN Napoli Centro San Giovanni di Dio, Fatebenefratelli, Brescia Department of Clinic Sciences and Bioimaging, University G. d'Annunzio Chieti-Pescara Interbalkan Medical Center of Thessaloniki Dept. of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer) Department of Child and Adolescent Psychiatry Department of Neuroscience, Catholic University, Roma IRCCS SDN Napoli Dept. of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences IDIBAPS (Institut d'Investigacions Biomèdiques August Pi Sunyer) Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] Department of Diagnostics and Public Health [Verona] Centre for Medical Image Computing Department of Radiology and Nuclear Medicine [Amsterdam] Toulouse NeuroImaging Center Centre de résonance magnétique biologique et médicale Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] University Medical Center Göttingen Department of Radiology and Nuclear Medicine [Amsterdam] Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Leipzig University / Universität Leipzig Centro San Giovanni di Dio, Fatebenefratelli, Brescia Università degli Studi di Perugia = University of Perugia Interbalkan Medical Center of Thessaloniki Interbalkan Medical Center of Thessaloniki IRCCS SDN Napoli IRCCS SDN Napoli Centro San Giovanni di Dio, Fatebenefratelli, Brescia Department of Clinic Sciences and Bioimaging, University G. d'Annunzio Chieti-Pescara Institut de Neurosciences des Systèmes Neurology Department, Hospital Clinic, IDIBAPS, Facultad de Medicina, Barcelona Institut de Neurosciences des Systèmes Dept. Neuroscience & Neurorehabilitation, IRCCS-San Raffaele-Pisana, Rome Leipzig University / Universität Leipzig Neuroradiology Unit, Perugia General Hospital, Perugia, Toulouse NeuroImaging Center Alzheimer Center Amsterdam Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Medical Physics Unit, Perugia General Hospital, Perugia Lille Neurosciences & Cognition - U 1172 Leipzig University / Universität Leipzig LVR-Clinic for Psychiatry and Psychotherapy, Institutes and Clinics of the University Duisburg-Essen, Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Laboratory of Neuroimaging of aging, Memory clinic and LANVIE Centro San Giovanni di Dio, Fatebenefratelli, Brescia
• Publié dans Magnetic Resonance Imaging le 27/10/2020

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Résumé : Brain vascular damage accumulate in aging and often manifest as white matter hyperintensities (WMHs) on MRI. Despite increased interest in automated methods to segment WMHs, a gold standard has not been achieved and their longitudinal reproducibility has been poorly investigated. The aim of present work is to evaluate accuracy and reproducibility of two freely available segmentation algorithms. A harmonized MRI protocol was implemented in 3T-scanners across 13 European sites, each scanning five volunteers twice (test-retest) using 2D-FLAIR. Automated segmentation was performed using Lesion segmentation tool algorithms (LST): the Lesion growth algorithm (LGA) in SPM8 and 12 and the Lesion prediction algorithm (LPA). To assess reproducibility, we applied the LST longitudinal pipeline to the LGA and LPA outputs for both the test and retest scans. We evaluated volumetric and spatial accuracy comparing LGA and LPA with manual tracing, and for reproducibility the test versus retest. Median volume difference between automated WMH and manual segmentations (mL) was -0.22[IQR = 0.50] for LGA-SPM8, -0.12[0.57] for LGA-SPM12, -0.09[0.53] for LPA, while the spatial accuracy (Dice Coefficient) was 0.29[0.31], 0.33[0.26] and 0.41[0.23], respectively. The reproducibility analysis showed a median reproducibility error of 20%[IQR = 41] for LGA-SPM8, 14% [31] for LGA-SPM12 and 10% [27] with the LPA cross-sectional pipeline. Applying the LST longitudinal pipeline, the reproducibility errors were considerably reduced (LGA: 0%[IQR = 0], p < 0.001; LPA: 0% [3], p < 0.001) compared to those derived using the cross-sectional algorithms. The DC using the longitudinal pipeline was excellent (median = 1) for LGA [IQR = 0] and LPA [0.02]. LST algorithms showed moderate accuracy and good reproducibility. Therefore, it can be used as a reliable cross-sectional and longitudinal tool in multi-site studies.

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Fichiers liés : Barkhof_Ribaldi.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Anda HunaAudrey GriveauDavid VindrieuxSara JaberJean-Michel FlamanDelphine GoehrigLamia AzziJean-Jacques MédardSophia DjebaliHector Hernandez-VargasRobert DanteLéa PayenJacqueline MarvelPhilippe BertolinoSébastien AubertPierre DubusDavid Bernard
• Organismes : Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Bordeaux Research In Translational Oncology [Bordeaux] Centre de Recherche en Cancérologie de Lyon Centre International de Recherche en Infectiologie Immunité et lymphocytes T CD8 cytotoxiques - Immunity and cytotoxic CD8 T-lymphocytes [CIRI] SFR Biosciences Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre International de Recherche en Infectiologie Immunité et lymphocytes T CD8 cytotoxiques - Immunity and cytotoxic CD8 T-lymphocytes [CIRI] Centre de Recherche en Cancérologie de Lyon Centre Hospitalier Régional Universitaire [CHU Lille] Institut de Pathologie [CHU Lille] Bordeaux Research In Translational Oncology [Bordeaux] Centre Hospitalier Universitaire de Bordeaux Centre de Recherche en Cancérologie de Lyon
• Publié dans Cell Death and Disease le 22/10/2020

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Résumé : Although aging is a major risk factor for most types of cancers, it is barely studied in this context. The transmembrane protein PLA2R1 (phospholipase A2 receptor) promotes cellular senescence, which can inhibit oncogene-induced tumor initiation. Functions and mechanisms of action of PLA2R1 during aging are largely unknown. In this study, we observed that old Pla2r1 knockout mice were more prone to spontaneously develop a wide spectrum of tumors compared to control littermates. Consistently, these knockout mice displayed increased Parp1, a master regulator of DNA damage repair, and decreased DNA damage, correlating with large human dataset analysis. Forced PLA2R1 expression in normal human cells decreased PARP1 expression, induced DNA damage and subsequent senescence, while the constitutive expression of PARP1 rescued cells from these PLA2R1-induced effects. Mechanistically, PARP1 expression is repressed by a ROS (reactive oxygen species)-Rb-dependent mechanism upon PLA2R1 expression. In conclusion, our results suggest that PLA2R1 suppresses aging-induced tumors by repressing PARP1, via a ROS–Rb signaling axis, and inducing DNA damage and its tumor suppressive responses.

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Fichiers liés : s41419-021-03468-3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Xiaojun LiWigneron J.-P.Frédéric FrappartSassan S SaatchiPhilippe CiaisRasmus FensholtDara EntekhabiMartin BrandtAlexandra KoningsXiangzhuo LiuMengjia WangAmen Al-YaariChristophe Moisy
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Laboratoire d'études en Géophysique et océanographie spatiales Interactions Sol Plante Atmosphère Nanjing University of Information Science and Technology Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC Department of Geosciences and Natural Resource Management [Copenhagen] MIT Parsons Laboratory Department of Geosciences and Natural Resource Management [Copenhagen] Stanford University Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Beijing Normal University Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : The vegetation optical depth (VOD), a vegetation index retrieved from passive or active microwave remote sensing systems, is related to the intensity of microwave extinction effects within the vegetation canopy layer. This index is only marginally impacted by effects from atmosphere, clouds and sun illumination, and thus increasingly used for ecological applications at large scales. Newly released VOD products show different abilities in monitoring vegetation features, depending on the algorithm used and the satellite frequency. VOD is increasingly sensitive to the upper vegetation layer as the frequency increases (from L-, C- to X-band), offering different capacities to monitor seasonal changes of the leafy and/or woody vegetation components, vegetation water status and aboveground biomass. This study evaluated nine recently developed/reprocessed VOD products from the AMSR2, SMOS and SMAP space-borne instruments for monitoring structural vegetation features related to phenology, height and aboveground biomass. For monitoring the seasonality of green vegetation (herbaceous and woody foliage), we found that X-VOD products, particularly from the LPDR-retrieval algorithm, outperformed the other VOD products in regions that are not densely vegetated, where they showed higher temporal correlation values with optical vegetation indices (VIs). However, LPDR X-VOD time series failed to detect changes in VOD after rainfall events whereas most other VOD products could do so, and overall daily variations are less pronounced in LPDR X-VOD. Results show that the reprocessed VODCA C- and X-VOD have almost comparable performance and VODCA C-VOD correlates better with VIs than other C-VOD products. Low frequency L-VOD, particularly the new version (V2) of SMOS-IC, show a higher temporal correlation with VIs, similar to C-VOD, in medium-densely vegetated biomes such as savannas (R ~ 0.70) than for other short vegetation types. Because the L-VOD indices are more sensitive to the non-green vegetation components (trunks and branches) than higher frequency products, they are well-correlated with aboveground biomass: (R ~ 0.91) across space between predicted and observed values for both SMOS-IC V2 and SMAP MT-DCA. However, when compared with forest canopy height, results at L-band are not systematically better than C- and X-VOD products. This revealed specific VOD retrieval issues for some ecosystems, e.g., boreal regions. It is expected that these findings can contribute to algorithm refinements, product enhancements and further developing the use of VOD for monitoring above-ground vegetation biomass, vegetation dynamics and phenology.

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Fichiers liés : S0034425720305812.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2021
• Auteurs : Jean KanyTewfik BenkalfateLuc FavardPhilippe TeissierChristophe CharoussetPierre Henri FlurinBertrand CouletLaurent HubertJérôme GarretPhilippe ValentiJean David WerthelNicolas Bonnevialle
• Organismes : Clinique de l'union Clinique mutualiste La Sagesse CHU Trousseau [Tours] Clinique du sport de Bordeaux-Mérignac Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Lapeyronie [CHU Montpellier] Centre Hospitalier Universitaire d'Angers Hôpital Ambroise Paré [AP-HP]
• Publié dans Orthopaedics & Traumatology: Surgery & Research le 26/10/2020

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Résumé : Introduction: Osteoarthritis (OA) of the shoulder in under-50 year-olds is rare, and treatment is delicate. Shoulder replacement incurs frequent long-term risk of progression and a high revision rate, making it unsuited to young active patients. The aim of the present study was to determine the epidemiology of shoulder OA in under-50 year-olds and to assess the clinical results of the various treatment options. Hypothesis: The main study hypothesis was that well-conducted non-operative treatment can allow shoulder replacement to be postponed. The secondary hypothesis was that anatomic total shoulder arthroplasty (TSA) is the treatment of choice when other options fail. Materials and methods: A multicenter retrospective study included primary (POA) and post-instability osteoarthritis (PIOA) in patients aged≤50years at symptom onset. Exclusion criteria comprised post-traumatic OA, rheumatoid arthritis and necrosis. Two hundred and sixty-six patients for 273 shoulders were included from 13 shoulder surgery centers: 2 types of non-operative treatment (28 by platelet-rich plasma [PRP] and 88 by viscosupplementation), 73 arthroscopies, and 150 implantations (62 humeral hemiarthroplasties [HA], comprising 10 hemi-metal, 24 hemi-pyrocarbon and 28 hemi-resurfacing; 77 anatomic total prostheses, and 11 reverse prostheses). Minimum follow-up was 12 months for non-operative treatment and 24 months for arthroplasty (some patients having both). Endpoints comprised Constant score, Subjective Shoulder Value (SSV) and number of complications/revision procedures. Results: Mean age at treatment was 43 years (range, 23-65 years), with 75% male predominance. Symptom onset was earlier in PIOA than in POA: 36 vs. 39 years (range, 20-50 years). PRP and viscosupplementation postponed implantation by a mean 3.5 years in 86% of cases, as did arthroscopy in 56%. ER1 restriction was the most negative factor. At 74 months' follow-up for HA and 95 months for TSA, mean Constant score was significantly lower for HA (56 vs. 67; p=0.004), with higher rates of complications (31% vs. 11%) and implant exchange (13% vs. 9%). Discussion/conclusion: PRP, viscosupplementation and arthroscopy allow implantation to be postponed until the shoulder becomes stiff and painful. In case of failure, TSA is the most effective solution in the medium-term. Level of evidence: IV a; therapeutic study - investigating the results of treatment.

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• Type de publi. : Rapport
• Date de publi. : 01/02/2021
• Auteurs : Jean-François SoussanaClaire WeillPatrick CaronJean-Luc ChottePierre-Benoît JolyPramod AggarwalMonique AxelosImke de BoerThierry CaquetCarole CarantaPhilippe ChemineauChristine CherbutMathieu DenisJessica FanzoPatrick FlammarionJean-François GuéganChristophe C. GouelSégolène Halley Des FontainesOlivier HamantDavid HannahMarion HetheringtonChristian HuygheCyril KaoAntoine KremerPeter LangridgeDavid LeadleyMichael LeeMarcus LindnerAllison LocontoMauricio Antonio LopesValérie Masson-DelmotteAlan MatthewsRaoul MilleRobert J. NaimanRiboli ElioJohan SchotYouba SokonaAndrew StirlingDaniel ToméMaria Concetta TomeiSébastien TreyerSaskia VisserJacques WerySarah Whitmee
• Organismes : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Université de Montpellier Institut de Recherche pour le Développement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement International Maize and Wheat Improvement Center Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Wageningen University and Research [Wageningen] Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement International Science Council John’s Hopkins Berman Institute of Bioethics Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut de Recherche pour le Développement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement University of Birmingham [Birmingham] University of Leeds Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement University of Adelaide Université Paris-Saclay Rothamsted Research European Forest Institute Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés Brazilian Agricultural Research Corporation = Empresa Brasileira de Pesquisa Agropecuária Intergovernmental Panel on Climate Change Université Paris-Saclay Trinity College Dublin Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement University of Washington [Seattle] Imperial College London Universiteit Utrecht / Utrecht University [Utrecht] Intergovernmental Panel on Climate Change University of Sussex Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement National Research Council of Italy | Consiglio Nazionale delle Ricerche Institut du Développement Durable et des Relations Internationales Wageningen University and Research [Wageningen] International Center for Agricultural Research in the Dry Areas University of Oxford

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Résumé : How scientists might better contribute to SDGs in the land sector? At the invitation of INRAE, a group of high-level international experts delivers a comprehensive and systemic approach.

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Fichiers liés : Rapport processus Royaumont (17 03)-CC-BY.pdf

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