Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : B. VollmerMatteo FossatiAlessandro BoselliMarian SoidaStephen D J GwynJean-Charles CuillandrePhilippe AmramSamuel BoissierMédéric BoquienGerhard Hensler
• Organismes : Observatoire astronomique de Strasbourg Max-Planck-Institut für Extraterrestrische Physik Laboratoire d'Astrophysique de Marseille Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie National Research Council of Canada Observatoire de Paris Laboratoire d'Astrophysique de Marseille Institut d'Astrophysique de Paris Universidad de Antofagasta Universität Wien = University of Vienna
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : NGC 4330 is one of the Virgo galaxies whose UV emission distributions show a tail structure. An associated tail structure is also observed in the HI and Hα emission distributions. Previous dynamical modeling has shown that the galaxy is approaching the cluster center and is therefore undergoing increasing ram pressure stripping. Recent stellar population fitting of deep optical spectra together with multiband photometry led to the determination of the time when star formation was quenched in the galactic disk. We introduce a new version of the dynamical model that includes not only the dense neutral gas, but also the diffuse ionized gas, and we aim to reproduce the HI, Hα, and UV distributions together with the star formation histories of the outer gas-free parts of the galactic disk. We present the results of 50 simulations with five different Lorentzian temporal ram pressure profiles and five different delays between the simulation onset and peak ram pressure. The delays were introduced to study the influence of galactic structure on the outcome of the simulations. The inclusion of diffuse gas stripping significantly changes the HI, UV, and Hα emission distributions. The simulations with diffuse gas stripping naturally led to vertical low surface density filaments in the downwind region of the galactic disk. These filaments occur less frequently in the simulations without diffuse gas stripping. The simulations with diffuse gas stripping led to better joint fits to the spectral energy distributions (SEDs) and optical spectra. The HI, near-UV, and Hα morphologies of the model snapshots that best reproduce the SEDs and optical spectra are sufficiently different to permit a selection of best-fit models. We conclude that the inclusion of diffuse gas stripping significantly improves the resemb+lance between the model and observations. Our preferred model yields a time to peak ram pressure of 140 Myr in the future. The spatial coincidence of the radio continuum and diffuse Hα tails suggests that both gas phases are stripped together. We suggest that the star formation in the outer tail is sporadic and low level, and this explains the absence of a significant amount of cosmic ray electrons there. Furthermore, we suggest that the mixed interstellar medium is ionized by collisions with the thermal electrons of the ambient intracluster medium, which confines the filaments.

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Fichiers liés : aa38507-20.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Paul GiraudPhilippe GiraudEliot NicolasPierre BoisselierMarc AlfonsiMichel RivesEtienne BardetValentin CalugaruGeorges NoelEnrique ChajonPascal PommierMagali MorelleLionel PerrierXavier LiemAnita BurgunJean-Emmanuel Bibault
• Organismes : Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
• Publié dans Cancers le 21/10/2020

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Résumé : Background: There is no evidence to support surgery or radiotherapy as the best treatment for resectable oropharyngeal cancers with a negative HPV status. Predictive algorithms may help to decide which strategy to choose, but they will only be accepted by caregivers and European authorities if they are interpretable. As a proof of concept, we developed a predictive and interpretable algorithm to predict locoregional relapse at 18 months for oropharyngeal cancers as a first step towards that goal. Methods: The model was based on clinical and Pyradiomics features extracted from the dosimetric CT scan. Intraclass correlation was used to filter out features dependant on delineation. Correlated redundant features were also removed. An XGBoost model was cross-validated and optimised on the HN1 cohort (79 patients), and performances were assessed on the ART ORL cohort (45 patients). The Shapley Values were used to provide an overall and local explanation of the model. Results: On the ART ORL cohort, the model trained on HN1 yielded a precision—or predictive positive value—of 0.92, a recall of 0.42, an area under the curve of the receiver operating characteristic of 0.68 and an accuracy of 0.64. The most contributory features were shape Voxel Volume, grey level size zone matrix Small Area Emphasis (glszmSAE), gldm Dependence Non Uniformity Normalized (gldmDNUN), Sex and Age. Conclusions: We developed an interpretable and generalizable model that could yield a good precision—positive predictive value—for relapse at 18 months on a different test cohort.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Déborah DucasseJonathan DuboisIsabelle JaussentJean‐michel AzorinB EtainSébastien GardChantal HenryThierry BougerolJean‐pierre KahnValérie AubinFrank BellivierRaoul BelzeauxCaroline DubertretJulien DubreucqPierre‐michel LlorcaJosephine LoftusChristine PasserieuxMircea PolosanLudovic SamalinMarion LeboyerAntoine YrondiDjamila BennabiEmmanuel HaffenJulia MaruaniEtienne AllauzeVincent CamusThierry A. d'AmatoOlivier DoumyJérôme HoltzmannChristophe LançonFanny MoliereRémi MoirandRaphaëlle Marie RichieriMathilde HornL. SchmittFlorian StephanJean‐baptiste GentyGuillaume VaivaMichel WalterWissam El-HageBruno AouizerateÉmilie OliéPhilippe Courtet
• Organismes : Institut Pascal Service Psychiatrie et psychologie médicale [CHU Toulouse] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Depression and Anxiety le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Biao CaoJean-Louis C. H. RoujeanJean-Philippe Gastellu-EtchegorryQinhuo LiuYongming DuJean-Pierre LagouardeHuaguo HuangHua LiZunjian BianTian HuBoxiong QinXueting RanQing Xiao
• Organismes : Aerospace Information Research Institute Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Aerospace Information Research Institute University of Chinese Academy of Sciences [Beijing] Aerospace Information Research Institute Interactions Sol Plante Atmosphère Beijing Forestry University Aerospace Information Research Institute Aerospace Information Research Institute Aerospace Information Research Institute Luxembourg Institute of Science and Technology Aerospace Information Research Institute University of Chinese Academy of Sciences [Beijing] Aerospace Information Research Institute University of Electronic Science and Technology of China [Chengdu] Aerospace Information Research Institute University of Chinese Academy of Sciences [Beijing]
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Radiometric measurements in the Thermal Infrared (TIR) domain exhibit an angular variation over most surface types, known as the Thermal Radiation Directionality (TRD) phenomenon. A primary objective of the ongoing development of TRD physical models is to perform a correction of the angular effects to obtain comparable land surface temperature products. In practice, it is advised to handle only the models having a limited number of input parameters for the purpose of operational applications. The use of semi-empirical kernel-driven models (KDMs) appears to be a good tradeoff between physical accuracy and computational efficiency as it was already demonstrated through a broad usage in the optical domain. It remains that the existing state-of-the-art 3-parameter TIR KDMs (RossThick-LiSparseR, LiStrahlerFriedl-LiDenseR, Vinnikov, and RoujeanLagouarde) underestimate the hotspot phenomenon, especially for continuous canopies marked by a narrow peak. In this study, a new general framework of TIR kernel-driven modeling is proposed to overcome such issue. It is a linear combination of three kernels (including a base shape kernel, a hotspot kernel with adjustable width and an isotropic kernel) with the ability to simulate the bowl, dome and bell shapes in the solar principal plane. Four specific 4-parameter models (Vinnikov-RoujeanLagouarde, LiStrahlerFriedl-RoujeanLagouarde, Vinnikov-Chen, and LiStrahlerFriedl-Chen, named “base shape kernel - hotspot kernel”) within the new framework were studied to assess their abilities to mimic the patterns of the directional brightness temperature for both continuous and discrete vegetation canopies. These four 4-parameter KDMs and four 3-parameter KDMs were comprehensively evaluated with 306 groups of simulated multi-angle datasets generated by a modernized analytical 4-stream radiative transfer model based on the Scattering by Arbitrarily Inclined Leaves (4SAIL), and a Discrete Anisotropic Radiative Transfer (DART) model considering different solar zenith angles (SZA), canopy architectures and component temperatures, and 2 groups of airborne measured multi-angle datasets over continuous maize and discrete pine forest. Results show that the four 4-parameter KDMs behave better than the four existing 3-parameter KDMs over continuous canopies (e.g. R2 increases from 0.661~0.970 to 0.940~0.997 and RMSE decreases from 0.17~0.71 to 0.07~0.16 when SZA = 30°) and discrete canopies (e.g. R2 increases from 0.791~0.989 to 0.976~0.996 and RMSE decreases from 0.10~0.84 to 0.08~0.21 when SZA = 30°). The new general framework with four parameters (three kernel coefficients and an adjustable hotspot width) improves the fitting ability significantly, compared to the four existing three-parameter KDMs, given the addition of one more degree of freedom. Results show that the coefficients of the base shape kernel, hotspot kernel and isotropic kernel are related to the temperature difference between leaf and background, temperature difference between sunlit component and shaded component, and the nadir brightness temperature, respectively. However, the estimated hotspot width depends on vegetation structure. The new kernel-driven modeling framework has the potential to be a tool for angular correction of multi-angle satellite observations and angular optimization of future multi-angle TIR sensors.

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Fichiers liés : Biao_general_framework.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Joanna WangNaiara BediagaRoberto MalloneEtienne LargerLeonard HarrisonJohn WentworthJean-Claude CarelNadia Tubiana-RufiLaetitia MartinerieAmélie PoidvinEvelyne Jacqz-AigrainLaurence CorvezVéronique BerruerJean-François GautierBaz BazNassima HaddadiFabrizio AndreelliChloé AmouyalSophie JaqueminetOlivier BourronEric DasqueAgnès HartemannAmal Lemoine-YazigiDanièle Dubois-LaforgueFlorence TravertMarilyne FeronPatrice RollandValérie VignaliMichel MarrePhilippe ChansonClaire BrietPierre-Jean GuillausseauLeila Ait-BachirCarole ColletFrédéric BeziaudVirginie Desforges-BulletGwenaelle Petit-AubertSophie Christin-MaitreBruno FèveCamille VatierNathalie BourcigauxCéline LautridouNajiba LahlouPrissile BakouboulaCaroline ElieMarie-Hélène MorelJean-Marc TreluyerMarie-Claude GagneraultClaire MaillardAnna Jones
• Organismes : Institut Cochin Institut Cochin Nutrition et obésités: approches systémiques (UMR-S 1269) Nutrition et obésités: approches systémiques (UMR-S 1269)
• Publié dans Acta Diabetologica le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Philippe FayemendyBenoît MarinAnaïs LabrunieYves BoirieStéphane WalrandNajate AchamrahMoïse CoëffierPierre-Marie PreuxGéraldine LautretteJean-Claude DesportPhilippe CouratierPierre Jésus
• Organismes : Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale Plate forme de bioinformatique et biostatistique Laboratoire de Biostatistique et d'Informatique Médicale Plate forme de bioinformatique et biostatistique Neuroépidémiologie Tropicale Centre de Recherche en Nutrition Humaine d'Auvergne Unité de Nutrition Humaine Unité de Nutrition Humaine Centre de Recherche en Nutrition Humaine d'Auvergne Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau Service de Nutrition [CHU Rouen] Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau Service de Nutrition [CHU Rouen] Neuroépidémiologie Tropicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges]
• Publié dans Journal of the Neurological Sciences le 27/10/2020

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Résumé : RationaleHypermetabolism (HM) in Amyotrophic lateral sclerosis (ALS) is the reflection of a high energy metabolic level, but this alteration seems controversial. The main objective of the study was to confirm the existence of HM during ALS compared to healthy subjects.MethodsA cohort of ALS patients was compared to a control group without metabolic disorder. The assessment included anthropometric criteria measurements, body composition by bioelectric impedance analysis and resting energy expenditure (REE) by indirect calorimetry. HM was defined as a variation > +10% between measured and calculated REE. Statistical analysis used Mann-Withney and Chi2 tests. Multivariate analysis included logistic regression.Results287 patients and 75 controls were included. The metabolic level was higher in ALS patients (1500 kcal/24 h [1290–1693] vs. 1230 kcal/24 h [1000–1455], p < 0.0001) as well as the REE/fat free mass ratio (33.5 kcal/kg/24 h [30.4–37.8] vs. 28.3 kcal/kg/24 h [26.1–33.6], p < 0.0001). 55.0% of ALS patients had HM vs. 13.3% of controls (p < 0.0001). HM was strongly and positively associated with ALS (OR = 9.50 [4.49–20.10], p < 0.0001).ConclusionsHM in ALS is a reality, which affects more than half of the patients and is associated with ALS. This work confirms a very frequent metabolic deterioration during ALS. The identification of HM can allow a better adaptation of the patients' nutritional intake.

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Fichiers liés : S0022510X20305931.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Thi Loi Daovan Thuan HoangAmal MagmounTran Duc Anh LySophie Alexandra BaronLinda HadjadjNaomie CanardTassadit DraliFrédérique GourietDidier RaoultPhilippe ParolaPierre MartyJean-Marc RolainPhilippe Gautret
• Organismes : Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Vecteurs - Infections tropicales et méditerranéennes Microbes Evolution Phylogénie et Infections Vecteurs - Infections tropicales et méditerranéennes
• Publié dans Travel Medicine and Infectious Disease le 25/10/2020

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Fichiers liés : S1477893920304373.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Jean-Pierre DelordAntoine ItalianoAhmad AwadaPhilippe AftimosNadine HouédéCéleste LebbéCeline PagesThierry LesimpleMonica DinulescuJan SchellensSuzanne LeijenSylvie RotteyVibeke KruseRichard KeffordSandrine FaivreCarlos Alberto Gomez-RocaArmin ScheulerGiorgio MassiminiEric Raymond
• Organismes : Institut Universitaire du Cancer de Toulouse - Oncopole Institut Bergonié [Bordeaux] Université de Bordeaux Institut Jules Bordet [Bruxelles] Institut Jules Bordet [Bruxelles] Institut de Cancérologie du GARD ICG - CHU Nîmes Immunologie humaine, physiopathologie & immunothérapie CIC Saint Louis Immunologie humaine, physiopathologie & immunothérapie CIC Saint Louis CRLCC Eugène Marquis Service de Dermatologie [Rennes] = Dermatology [Rennes] Netherlands Cancer Institute Utrecht Institute for Pharmaceutical Sciences Netherlands Cancer Institute Ghent University Hospital Heymans Institute of Pharmacology Ghent University Hospital Heymans Institute of Pharmacology Macquarie University [Sydney] Melanoma Institute Australia [Sydney, NSW, Australia] Hôpital Beaujon [AP-HP] Institut Universitaire du Cancer de Toulouse - Oncopole EMD Serono Research & Development Institute Merck [Darmstadt] Hôpital Beaujon [AP-HP]
• Publié dans Targeted Oncology le 01/11/2020

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Résumé : The Ras/Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (Ras/Raf/MEK/ERK) signaling cascade is frequently constitutively activated in human cancers. Pimasertib is a selective and potent adenosine triphosphate non-competitive MEK1/2 inhibitor. Objective: Our objectives were to describe the results of a phase I, first-in-human, dose-escalation trial of pimasertib that investigated the maximum tolerated dose, recommended phase II dose, and safety, as well as other endpoints. Patients and methods: Four dosing schedules of pimasertib (once daily [qd], 5 days on, 2 days off; qd, 15 days on, 6 days off; continuous qd; continuous twice daily [bid]) were evaluated in patients with advanced solid tumors. Each treatment cycle lasted 21 days. The primary objective was to determine the maximum tolerated dose based on dose-limiting toxicities (DLTs) evaluated during cycle 1, and the recommended phase II dose (RP2D). Secondary objectives included safety, pharmacokinetics, pharmacodynamics, and antitumor activity. Results: Overall, 180 patients received pimasertib (dose range 1-255 mg/day). DLTs were mainly observed at doses ≥ 120 mg/day and included skin rash/acneiform dermatitis and ocular events, such as serous retinal detachment. The most common drug-related adverse events were consistent with class effects, including diarrhea, skin disorders, ocular disorders, asthenia/fatigue, and peripheral edema. The median time to maximum pimasertib concentration was 1.5 h across dosing schedules, and the apparent terminal half-life was 5 h across qd dosing schedules. Pimasertib decreased ERK phosphorylation within 2 h of administration, which was maintained for up to 8 h at higher doses and prolonged with bid dosing. Conclusions: Based on the safety profile and efficacy signals, a continuous bid regimen was the preferred dosing schedule and the RP2D was defined as 60 mg bid.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : John B WhitfieldS MassonSuthat LiangpunsakulSebastian MuellerGuruprasad P AithalFlorian EyerDermot GleesonA ThompsonFelix StickelMichael SoykaAnn K DalyHeather J CordellTatiana ForoudLawrence LumengMunir PirmohamedBertrand NalpasJean-Marc JacquetRomain MoirandPierre NahonSylvie S. NaveauPascal PerneyPaul S HaberHervé SeitzC DayPhilippe MathurinTimothy R MorganDevanshi Seth
• Organismes : QIMR Berghofer Medical Research Institute Newcastle University [Newcastle] Indiana University System Universität Heidelberg [Heidelberg] = Heidelberg University University of Nottingham, UK Technische Universität Munchen = Technical University Munich = Université Technique de Munich Royal Hallamshire Hospital University of Liverpool University hospital of Zurich [Zurich] University-Hospital Munich-Großhadern [München] Newcastle University [Newcastle] Newcastle University [Newcastle] Indiana University School of Medicine Indiana University System University of Liverpool Hôpital Universitaire Carémeau [Nîmes] Hôpital Universitaire Carémeau [Nîmes] Nutrition, Métabolismes et Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Génomique Fonctionnelle des Tumeurs Solides Hôpital Jean Verdier [AP-HP] AP-HP - Hôpital Antoine Béclère [Clamart] Hôpital Universitaire Carémeau [Nîmes] The University of Sydney Universität Heidelberg [Heidelberg] = Heidelberg University Newcastle University [Newcastle] Centre Hospitalier Régional Universitaire [CHU Lille] California State University [Long Beach] University of California The University of Sydney
• Publié dans The American Journal of Gastroenterology le 22/10/2020

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Résumé : Introduction - Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction of risk. Methods - We conducted a multicenter case-control study (GenomALC) comparing 1,293 cases (with alcohol-related cirrhosis, 75.6% male) and 754 controls (with equivalent alcohol exposure but no evidence of liver disease, 73.6% male). Information confirming or excluding cirrhosis, and on alcohol intake and other potential risk factors, was obtained from clinical records and by interview. Case-control differences in risk factors discovered in the GenomALC participants were validated using similar data from 407 cases and 6,573 controls from UK Biobank. Results - The GenomALC case and control groups reported similar lifetime alcohol intake (1,374 vs 1,412 kg). Cases had a higher prevalence of diabetes (20.5% (262/1,288) vs 6.5% (48/734), P = 2.27 × 10) and higher premorbid body mass index (26.37 ± 0.16 kg/m) than controls (24.44 ± 0.18 kg/m, P = 5.77 × 10). Controls were significantly more likely to have been wine drinkers, coffee drinkers, smokers, and cannabis users than cases. Cases reported a higher proportion of parents who died of liver disease than controls (odds ratio 2.25 95% confidence interval 1.55-3.26). Data from UK Biobank confirmed these findings for diabetes, body mass index, proportion of alcohol as wine, and coffee consumption. Discussion - If these relationships are causal, measures such as weight loss, intensive treatment of diabetes or prediabetic states, and coffee consumption should reduce the risk of alcohol-related cirrhosis.

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Fichiers liés : Whitfield et al. - 2021 - Obesity, Diabetes, Coffee, Tea, and Cannabis Use A.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Mathieu ChalouniStanislas PolPhilippe SogniHélène FontaineKarine LacombeJean Marc-LacombeLaure EsterleCeline DorivalMarc BourlièreFirouzé Bani-SadrVictor de LedinghenDavid ZucmanDominique LarreyDominique Salmon-CéronFabrice CarratLinda Wittkop
• Organismes : Team MORPH3EUS CIC Bordeaux Immunité Innée - Innate Immunity Hôpital Cochin [AP-HP] Immunité Innée - Innate Immunity Hôpital Cochin [AP-HP] Immunité Innée - Innate Immunity Hôpital Cochin [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] INSERM-TRANSFERT [Paris] Team MORPH3EUS Institut Pierre Louis d'Epidémiologie et de Santé Publique Hôpital Saint-Joseph [Marseille] Hôpital universitaire Robert Debré [Reims] Bordeaux Research In Translational Oncology [Bordeaux] Hôpital Haut-Lévêque [CHU Bordeaux] Hôpital Foch [Suresnes] Hôpital Saint-Éloi [Montpellier] Hôpital Cochin [AP-HP] Hôpital Hôtel-Dieu [Paris] Université Paris Cité Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Institut de Santé Publique, d'Epidémiologie et de Développement Team MORPH3EUS CIC Bordeaux
• Publié dans Journal of Hepatology le 23/10/2020

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Résumé : Background & aims: Direct-acting antivirals (DAA) lead to high sustained virological response (SVR) rates and decrease the risk of disease progression. We compared SVR rates and all-cause, liver- and non-liver-related deaths, liver-related events, and non-liver-related cancers in HIV/HCV-coinfected and HCV-monoinfected participants from 2 French cohort studies after initiation of DAA treatment. Methods: Up to 4 HCV-monoinfected participants from the ANRS CO22 HEPATHER cohort were matched by age and sex to each HIV/HCV-coinfected patient from the ANRS CO13 HEPAVIH cohort; both are nationwide, prospective, multicentre, and observational. Participants were initiated on DAAs between March 2014 and December 2017. Cox proportional hazards models adjusted by age, sex, duration since HCV diagnosis, HCV transmission routes, HCV genotypes, cirrhosis, tobacco, alcohol consumption, and SVR (time dependent) were used. Results: A total of 592 HIV/HCV-coinfected and 2,049 HCV-monoinfected participants were included; median age was 53.3 years (inter-quartile range: 49.6-56.9) and 52.9 years (49.6; 56.7), 1,498 (73.1%) and 436 (73.6%) were men, and 159 (28.8%) and 793 (41.2%) had cirrhosis, respectively. SVR was observed in 92.9% and 94.6%, respectively. HIV coinfection was associated with higher risk of all-cause death (hazard ratio [HR] 1.93; 95% CI 1.01-3.69), non-liver-related death (HR 2.84; 95% CI 1.27-6.36), and non-liver-related cancer (HR 3.26; 95% CI 1.50-7.08), but not with liver-related-death (HR 1.04; 95% CI 0.34-3.15) or liver-related events (HR 0.66; 95% CI 0.31-1.44). Conclusions: After DAA treatment, HIV-coinfected individuals had similar SVR rates and risk of liver-related deaths and events compared with HCV-monoinfected individuals, but had a higher risk of all-cause and non-liver-related deaths and non-liver-related cancers. Lay summary: We compared the risk of several clinical events in participants infected by human immunodeficiency virus and hepatitis C virus with those infected with hepatitis C virus alone, matched on age and sex, after treatment with contemporary direct-acting antivirals. We found a higher risk of all-cause deaths, non-liver-related deaths, and non-liver-related cancers in participants coinfected with the human immunodeficiency virus and hepatitis C virus, and no differences for the risk of liver-related deaths or events. Trial registration: ClinicalTrials.gov NCT03324633 NCT01953458.

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Fichiers liés : inserm-03332406.pdf

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