Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 12/09/2025
• Auteurs : Jean-Charles PicaudOlivier ClarisMercedes Gil-CamposIgnacio Salamanca de la CuevaLuc CornettePhilippe AllietAndré LekeMireille CastanetHugues PiloquetVirginie de HalleuxDelphine MitanchezYvan VandenplasPierre MatonFrank JochumDirk OlbertzSergio Negre PolicarpoLuca LavalleCecilia FumeroPaula Rodriguez-GarciaJanne Marie MollIrma Silva-ZolezziBoutaina ZemraniNicholas HaysNorbert SprengerJavier Miranda-Mallea
• Organismes : Hôpital de la Croix-Rousse [CHU - HCL] Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Université Claude Bernard Lyon 1 Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Neuroendocrine, Endocrine and Germinal Differentiation Communication Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Physiopathologie des Adaptations Nutritionnelles Centre Hospitalier Régional Universitaire de Tours Vrije Universiteit Brussel [Bruxelles]
• Publié dans Frontiers in Nutrition le 25/10/2020

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Fichiers liés : 2025_Picaud_Front_Nutrition.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 10/09/2025
• Auteurs : Zhaojie ChaiGuansheng LiPapa Alioune NdourPhilippe ConnesPierre BuffetMélanie FrancoGeorge Em Karniadakis
• Organismes : Brown University Brown University Biologie Intégrée du Globule Rouge Laboratoire Interuniversitaire de Biologie de la Motricité Biologie Intégrée du Globule Rouge Biologie Intégrée du Globule Rouge Brown University
• Publié dans PLoS Computational Biology le 27/10/2020

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Résumé : Gaucher Disease (GD) is a rare genetic disorder characterized by a deficiency in the enzyme glucocerebrosidase, leading to the accumulation of glucosylceramide in various cells, including red blood cells (RBCs). This accumulation results in altered biomechanical properties and rheological behavior of RBCs, which may play an important role in blood rheology and the development of bone infarcts, avascular necrosis (AVN) and other bone diseases associated with GD. In this study, dissipative particle dynamics (DPD) simulations are employed to investigate the biomechanics and rheology of blood and RBCs in GD under various flow conditions. The model incorporates the unique characteristics of GD RBCs, such as decreased deformability and increased aggregation properties, and aims to capture the resulting changes in RBC biophysics and blood viscosity. This study is the first to explore the Young's modulus and aggregation parameters of GD RBCs by validating simulations with confocal imaging and experimental RBC disaggregation thresholds. Through in silico simulations, we examine the impact of hematocrit, RBC disaggregation threshold, and cell stiffness on blood viscosity in GD. The results reveal three distinct domains of GD blood viscosity based on shear rate: the aggregation domain, where the RBC disaggregation threshold predominantly influences blood viscosity; the transition area, where both RBC aggregation and stiffness impact on blood viscosity; and the stiffness domain, where the stiffness of RBCs emerges as the primary determinant of blood viscosity. By analyzing RBC mechanical properties and blood viscosity in relation to bone disease, we find that the RBC aggregation properties, deformability, and blood viscosity, may contribute to its onset. These findings enhance our understanding of how changes in RBC properties impact on blood viscosity and may affect bone health, offering a partial explanation for the bone complications observed in GD patients.

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Fichiers liés : journal.pcbi.1012705.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 09/09/2025
• Auteurs : Sofia Avalos-AlaisMaciej JedynakAnthony BoyerBlandine Chanteloup-ForêtCristiana PinheiroChristopher ClineSara ParmigianiYasser Alemán-GómezPatric HagmannCorey KellerOlivier DavidClaude AdamVincent NavarroArnaud BirabenAnca NicaDominique MenardMilan BrazdilRobert KubaJitka KočvarováMartin PailIrena DoležalováFrançois DubeauJean GotmanPhilippe RyvlinJean IsnardHélène CatenoixAlexandra MontavontSylvain RheimsFabrice BartolomeiAgnès TrébuchonAileen McgonigalWenjing ZhouHaixiang WangSinclair LiuZhang WeiZhu DanGuo QiangHu XiangshuLi HuaHua GangWang WenshengMei XiFeng YigangRima NabboutMarie BourgeoisAnna KamińskaThomas BlauwblommeMercedes GarcésAntonio ValentinRinki SinghLiisa MetsähonkalaEija GailyLeena LauronenMaria PeltolaFrancine ChassouxElizabeth LandréPhilippe DerambureWilliam SzurhajMaxime ChochoisEdouard HirschMaria Paola ValentiJulia SchollyLuc ValtonMarie DenuelleJonathan CurotRodrigo RocamoraAlessandro PrincipeMiguel LeyIoana MindrutaAndrei BarboricaStefano FrancioneRoberto MaiLino NobiliIvana SartoriLaura TassiLouis MaillardJean-Pierre VignalJacques JonasLouise TyvaertMathilde ChipauxDelphine TaussigPhilippe KahaneLorella MinottiAnne-Sophie JobVéronique MichelMarie de MontaudoinJérôme AupyViviane BouilleretAna Maria PetrescuPascal MasnouClaire DussauleMarion QuirinsDelphine TaussigCarmen BarbaRenzo GuerriniMatteo LengeElisa Nacci
• Organismes : Institut de Neurosciences des Systèmes Institut de Neurosciences des Systèmes Institut de Neurosciences des Systèmes [GIN] Grenoble Institut des Neurosciences IFR de neurosciences de Strasbourg Stanford University Stanford University Université de Lausanne = University of Lausanne Université de Lausanne = University of Lausanne Stanford University Institut de Neurosciences des Systèmes Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and University of Lyon, Lyon, France
• Publié dans Brain - A Journal of Neurology le 29/10/2020

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Résumé : Abstract The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions. This map is derived from intracranial evoked potential analysis of 48,797 intracranial direct electrical stimulation runs across 759 implantations in 724 patients with refractory epilepsy (368 male, 354 female, two unspecified; mean age 24±13.5 years). We mapped probabilistic connectivity between brain parcels with adaptive resolution – higher resolution in the LPFC in the hemisphere of interest and lower elsewhere – maintaining statistical power while achieving 95% average confidence interval of ∼0.03 for connectivity probability estimates. In addition, the significance threshold (p-value) for probabilistic connectivity was obtained from surrogate distributions. Overall, we observed remarkable symmetry between afferent and efferent connectivity patterns of the LPFC, with a slight preference for efferent connections (mean slope = 0.92±0.09, mean R² = 0.93±0.025). For example, connections between the inferior frontal gyrus (IFG) and anterior cingulate showed notable directional asymmetry. The IFG strongly projected to most brain networks compared to other LPFC regions, with the strongest connectivity to the ventral attention network (0.26±0.01 compared to values between 0.15 and 0.21 in other LPFC regions). Posterior DLPFC demonstrated stronger connectivity to brain networks compared to anterior DLPFC regions (eg. 0.21±0.01 vs 0.15±0.01 for connectivity to ventral attention network), with the exception of the limbic cortex. All LPFC subregions strongly projected to the fronto-parietal (greater than 0.17) and ventral attention (greater than 0.15) networks, with moderate connections to the default network (between 0.1 and 0.15, with the maximum corresponding to superior DLPFC). Finally, latency analysis suggested that the left LPFC's influence on ipsilateral emotion-related regions is primarily polysynaptic, with particularly strong pathways from IFG to amygdala (0.16±0.02) and hippocampus (0.12±0.01). Taken together, these comprehensive connectivity maps provide a new detailed electrophysiological foundation for understanding the functional anatomy of LPFC and guiding targeted brain stimulation protocols.

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• Type de publi. : Article dans une revue
• Date de publi. : 09/09/2025
• Auteurs : Caroline BraudP KeravecIngrid NeunaberSandrine AubrunJean-Luc AttiéPierre DurandPhilippe RicaudJean-François GeorgisEmmanuel LeclercLise MourreClaire Taymans
• Organismes : Laboratoire de science et génie des surfaces Centre d'études spatiales de la biosphère Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique Centre national de recherches météorologiques
• Publié dans Wind Energy Science le 13/05/2020

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Résumé : Abstract. A comprehensive meteorological data set from an operational wind farm, consisting of six 2 MW turbines, has been made available. A meteorological mast, equipped with sonic anemometers at four different heights, was installed at the center of the farm and has collected data over 3 years. The data set is further supplemented with radiometer measurements for atmospheric stability analysis. Simultaneously, supervisory control and data acquisition (SCADA) data were acquired to provide operational information about the wind turbines, including inter alia power production and wind direction. Additionally, the turbine blades were scanned to support aerodynamic simulations. This unique and comprehensive database has been made accessible to the research community through the AERIS platform.

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Fichiers liés : wes-10-1929-2025.pdf

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• Type de publi. :
• Date de publi. : 08/09/2025
• Auteurs : Emma AraignousPierre BourdaudKarine R HeerahJuliette delavenneLydie CouturierYann PlanqueA AcouE AlmoricHugues BlanchetFrida Ben Rais LasramN BuissonAntoine ChabrolleDominique ClorennecMagali CollinL DespringhereR FabletC FerryF GallienLisa GarnierL IborraFrançois Le Loc’hNathalie NiquilG NolibéJean-Philippe PezyEmma QuintardF SamaranT TrancartN UrienJehanne Prevot
• Organismes : Patrimoine naturel Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Laboratoire des Sciences de l'Environnement Marin (LEMAR) Morphodynamique Continentale et Côtière Normandie Université Centre National de la Recherche Scientifique Université de Caen Normandie Morphodynamique Continentale et Côtière

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/09/2025
• Auteurs : Clément MathieuJérôme WassermannSébastien PéraltaRonan L. HébertPierre M. AdlerJean-Louis GalliasPhilippe Bromblet
• Organismes : Laboratoire de mécanique et matériaux du génie civil Laboratoire de mécanique et matériaux du génie civil Laboratoire de Physico-chimie des Polymères et des Interfaces ISTeP-CY Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols Laboratoire de mécanique et matériaux du génie civil Centre Interdisciplinaire de Conservation et Restauration du Patrimoine

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Résumé : Salt crystallization within the heritage stones is recognized as a major cause of damage. In particular, sodium sulfates which are very commonly encountered in natural environment, are recognized as the most destructive salts. The mechanisms leading to the stone damage are still not well defined. The identification of the salt crystallization sequence and of the spatial distribution at the pore scale, remain a real scientific challenge. The sodium sulfate crystallization within true natural porous network is studied at pore scales during weathering cycles. Savonnières limestone samples are exposed to salt by successive imbibition and evaporation of a 1 mol/L sodium sulfate solution at constant ambient temperature and relative humidity conditions. Phases characterization and topography cartographies are performed using Raman spectroscopy and Atomic Force Microscopy respectively. The two combined technics on a same limestone sample help to characterize the spatial distribution of neocrystallized salt phases within the porous network. The results shown that the micro and the macropores of the limestones are mainly filled by thenardite phase V microcrystals. Large crystals of mirabilite could be formed in the stone before the dehydration. Gypsum crystals have been observed too and are located in the micropores of the limestone: at interfacial zones between oolites and sparitic cement and also in the micropores of the oolites. The presence of gypsum could indicate a chemical reaction between the sodium sulfate solution and the limestone.

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• Type de publi. :
• Date de publi. : 08/09/2025
• Auteurs : Laurie MichaudAurore RaouxJean-Philippe PezyEmma AraignousPierre BourdaudNathalie Niquil
• Organismes : Morphodynamique Continentale et Côtière Morphodynamique Continentale et Côtière Morphodynamique Continentale et Côtière France Énergies Marines [Brest] France Énergies Marines [Brest] Morphodynamique Continentale et Côtière Normandie Université Centre National de la Recherche Scientifique Université de Caen Normandie

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• Type de publi. : Article dans une revue
• Date de publi. : 08/09/2025
• Auteurs : Maëva VeyssièreNassim HammoudiLionel Le BourhisDéborah HassidJoëlle BonnetMy-Linh Tran MinhClotilde BaudryJean-Marc GornetVictor ChardinyPhilippe SeksikStéphane NanceyFranck CarbonnelXavier TretonPauline WilsAnthony BuissonArnaud BoureilleXavier HébuterneMélanie SerreroMathurin FumeryEdouard LouisPierre BlancLaurent Peyrin-BirouletMadeleine BezaultVassili SoumelisMatthieu Allez
• Organismes : Immunologie humaine, physiopathologie & immunothérapie Hopital Saint-Louis [AP-HP] Ecotaxie, microenvironnement et développement lymphocytaire Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Service d'hépato-gastro-entérologie Hopital Saint-Louis [AP-HP] Centre de Recherche Saint-Antoine CHU Saint-Antoine [AP-HP] Hospices Civils de Lyon Centre de recherche en épidémiologie et santé des populations Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Hôpital Claude Huriez [Lille] Institute for Translational Research in Inflammation - U 1286 CHU Clermont-Ferrand Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nice Hôpital Nord [CHU - APHM] Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Centre Hospitalier Universitaire de Liège CHU Montpellier = Montpellier University Hospital Service d'Hépato-gastro-entérologie [CHRU Nancy] Remind Study Group Saint-Louis Research Institute, INSERM U976—HIPI Unit, University of Paris, Paris, France Institut de Recherche Saint Louis
• Publié dans Journal of Crohn's and Colitis le 31/10/2020

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Résumé : Background and aims Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), remain heterogeneous disorders with variable response to biologics. Post-operative recurrence in CD is common despite surgery and prophylactic biotherapies. Understanding the inflammatory mediators associated with recurrence and treatment response could pave the way for personalized strategies. Methods We analyzed serum inflammatory protein signatures using proteomics in two prospective cohorts. The REMIND cohort included post-operative CD patients undergoing ileocecal resection with endoscopic assessment at 6 months (M6). Serum samples were collected at surgery and six months later. The ELYP cohort consisted of active IBD patients starting new biotherapies (anti-TNF, ustekinumab, or vedolizumab). Serum samples were collected pre- and post-treatment (Weeks 14 and 52). Results In the REMIND cohort, proteomic analysis revealed elevated levels of IFN-γ, CXCL9, and MMP-10 in patients with recurrence, with concentrations associated with recurrence severity. Preoperative MMP-10 levels predicted severe recurrence (AUC = 0.70). Under biotherapies, treatment-specific proteins were associated with recurrence: CXCL9 for anti-TNF and OSM/TGFα modules for ustekinumab. In the ELYP cohort, IFN-γ and CXCL9 were significantly elevated in CD compared to UC and associated with disease activity. Early response to anti-TNF treatment (Week 14) was associated with reductions in CXCL9, MMP-10, and OSM, while deep remission (Week 52) correlated with decreases in CXCL9 and OSM. Conclusion Our findings reveal inflammatory blood proteomic signatures associated with post-operative recurrence and biologic treatment failure in IBD. Several key biomarkers were identified. These results support the rationale for personalized approaches, including combination therapies targeting multiple pathways. ClincialTrials.gov number, NCT02693340 and NCT02693340

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/09/2025
• Auteurs : Roel AaijAhmed Sameh Wagih AbdelmottelebCarlos Abellan BetetaFernando Jesus AbudinénThomas AckernleyAyomide Matthew AdefisoyeBernardo AdevaMarco AdinolfiPatrik Harri AdlarsonChristina AgapopoulouChristine Angela AidalaZiad AjaltouniSimon AkarKazuyoshi AkibaMuzammil AktharPietro AlbicoccoJohannes AlbrechtRamunas AleksiejunasFederico AlessioPaula Alvarez CartelleRenaud AmalricSandra AmatoJake Lewis AmeyYasmine AmhisLiupan AnLucio AnderliniMartin AnderssonPasquale AndreolaMirco AndreottiSergio Andres EstradaAlessia AnelliDong AoCarolina ArataFlavio ArchilliZaratsyan AregMatteo ArgentonSergio Arguedas CuendisLisa ArnoneAlexander ArtamonovMarina ArtusoElie AslanidesRita Ataíde da SilvaMichele AtzeniBenjamin AudurierJuliette AuthierDavid BacherIrene Bachiller PereaSebastian BachmannMarie BachmayerJohn BackPablo Baladron RodriguezVladislav BalaguraAnna BalboniWander BaldiniZachary BaldwinLuca BalzaniHaoran BaoJuan Baptista de Souza LeiteCarlos Javier Barbero PretelMatteo BarbettiIvanildo Rui BarbosaRoger BarlowMikhail BarnyakovSergey BarsukWilliam BarterJustin BartzSaliha BashirBaasansuren BatsukhPiera BattistaAurelio BayAnja BeckMaik BeckerFranco BedeschiIgnacio BediagaNoah Albin BehlingSamuel BelinAlberto BellavistaKonstantin BelousIlia BelovIvan BelyaevGaya BenaneGiovanni BencivenniEli Ben-HaimAlexander BerezhnoyRoland BernetSergi Bernet AndresAlessandro BertolinFederico BettiJosh BexOleg BezshyykoSenjuti BhattacharyaJihyun BhomMartin Stefan BiekerNicolo Vladi BiesuzAlice BiolchiniMatthew BirchFionn Caitlin Ros BishopAlexander BitadzeAndrea BizzetiThomas BlakeFrederic BlancJonah Evan BlankSteven BluskVladimir BocharnikovJulian Alexander BoelhauveOscar Boente GarciaThomas BoettcherAbhishek BohareAlexey BoldyrevCarolina BolognaniRiccardo BolzonellaRiccardo BonacciNikolay BondarAleksandar BordeliusFederica BorgatoSilvia BorghiMartino BorsatoJozef Tomasz BorsukElia BottalicoSonia Amina BouchibaMarcelo BovillThemistocles BowcockAlexandre BoyerConcezio BozziJames Daniel BrandenburgAlexandre Brea RodriguezNils BreerJolanta BrodzickaJames David BrownDavide BrunduEmma BuchananMarta Burgos MarcosAodhan Tomas BurkeChristopher BurrClarissa ButiJordy Sebastiaan ButterJan BuytaertWiktor ByczynskiSandro CadedduHao CaiYuman CaiAlois CailletRoberto CalabreseSaul Calderon RamirezLukas CaleficeMarta CalviMiriam Calvo GomezPatricia Camargo MagalhaesJose Ivan Cambon BouzasPierluigi CampanaAngel Fernando Campoverde QuezadaSimone CapelliMarco CaporaleLorenzo CapriottiRonald Gerardo Caravaca-MoraAngelo CarboneLidia Carcedo SalgadoRoberta CardinaleAlessandro CardiniPaolo CarnitiLeon David CarusAdrian Casais VidalRowina CasparyGianluigi CasseMarco CattaneoGiovanni CavalleroViola CavalliniSara CelaniIrene CelestinoSara CesareAbbie Jane ChadwickIbrahim ChahrourHao ChangMatthew CharlesPhilippe CharpentierEvridki ChatzianagnostouRacha CheaibMaximilien ChefdevilleChen ChenJou-An ChenShanzhen ChenZewen ChenAlex Chen HuMostafa CherifAleksei ChernovSerhii ChernyshenkoXenofon ChiotopoulosVeronika ChobanovaMarcin ChrzaszczAleksei ChubykinVladimir ChulikovPaolo CiambroneXabier Cid VidalGregory CiezarekPierfrancesco CifraPeter ClarkeMarco ClemencicHarry CliffJoel ClosierCarlos Eduardo Cocha ToapaxiVictor CocoJulien CoganEric CognerasLucian CojocariuSpencer Edward CollavitiPaula CollinsTommaso ColomboMarco ColonnaAlbert Comerma-MontellsLiliana CongedoJames ConnaughtonAndrea ContuNaomi CookeGiulio CordovaChristian Andres CoronelImanol CorredoiraAnthony CorreiaGloria CortiJozie Cottee MeldrumBenjamin CouturierDaniel Charles CraikMelissa Maria Cruz TorresEsteban Curras RiveraRobert CurrieCesar Luiz da SilvaShakhzod DadabaevXinchen DaiElena Dall'OccoJeremy DalsenoCarmelo d'AmbrosioJessy DanielGabriella DarzeAlexander DavidsonJonathan Edward DaviesOscar de Aguiar FranciscoCamilla de AngelisFederico de BenedettiJan de BoerKristof de BruynStefano de CapuaMichel de CianUlisses de Freitas Carneiro da GracaErika de LuciaJussara de MirandaLeandro de PaulaMarilisa de SerioPatrizia de SimoneFabio de VellisJacco de VriesFrancesco DebernardisDaniel DecampSam Michael DekkersLuigi del BuonoBlaise DelaneyHans Peter DembinskiJianqiao DengVadym DenysenkoOlivier DeschampsFrancesco DettoriBiplab DeyPasquale Di NezzaIgor DiachkovSergey DidenkoShuchong DingYiyang DingLucas DittmannVasyl DobishukAleksandrina DochevaAlex Patrick DohenyChenzhi DongAmanda May DonohoeFrancesca DordeiAlberto dos ReisAndrew Jay DowlingLea Marie Sophie DreyfusWeisong DuanPiotr Jakub DudaLaurent DufourViacheslav DukPaolo DuranteMaciej DurasJohn Matthew DurhamOzgur DurmusAgnieszka DziurdaAlexey DzyubaSajan EasoEllinor EcksteinUlrik EgedeArtem EgorychevVictor EgorychevStephan EisenhardtEnoch EjopuLars EklundMohamed ElashriDaniel Guillermo Elizondo BlancoJan Hendrik EllbrachtScott ElyAlexandru EneJonas Nathanael EschleSevda EsenTimothy EvansFederica FabianoSaba FaghihLucas FalcaoBo FangRiccardo FantechiLisa FantiniMaria FariaKeira Gwyn FarmerFloris Patrick Jan FassinDavide FazziniLukasz Jerzy FelkowskiMingjie FengAlvaro Fernandez CasaniMiguel Fernandez GomezAlex Daniel FernezFabio FerrariFernando Ferreira RodriguesMartina FerrilloMassimiliano Ferro-LuzziSergey FilippovRosa Anna FiniMassimiliano FioriniMiroslaw FirlejKamil Leszek FischerDillon Scott FitzgeraldConor FitzpatrickTomasz FiutowskiFrederic FleuretAlex FominMarianna FontanaLucas Arthur ForemanRoger FortyDaniel Foulds-HoltVinicius Franco LimaManuel Franco SevillaMarkus FrankEdoardo FranzosoGiulia FrauChristoph FreiDavid Anthony FridayJinlin FuQuentin FühringTommaso FulghesuGiuliana GalatiMaria Domenica GalatiAbraham Gallas TorreiraDomenico GalliSilvia GambettaMiriam GandelmanPaolo GandiniBilal Ahmad GanieHan GaoRui GaoTian-Qi GaoYang GaoYuanning GaoYuxi GaoLuis Miguel Garcia MartinPaula Garcia MorenoJulián García PardiñasParker Taittinger GardnerLluis GarridoClara GasparArsenii GavrikovLouis Lenard GerkenEvelina GersabeckMarco GersabeckTimothy GershonSimon GhizzoZahra GhorbanimoghaddamFotis Ioannis GiasemisValerie GibsonHenryk Karol GiemzaAlexander Leon GilmanMatteo GiovannettiAlessandra GioventùLucas George GirardeyMaciej Artur GizaFabian Christoph GlaserVladimir GligorovCarla GöbelLarysa Golinka-BezshyykoElisabet GolobardesDmitry GolubkovAndrey GolutvinSergio Gomez FernandezWojciech GomulkaIsadora Gonçales VazFernanda Goncalves AbrantesMateusz GoncerzGuanghua GongJames Andrew GoodingIgor Vladimirovich GorelovClaudio GottiEkaterina GovorkovaJascha Peter GrabowskiLuis Alberto Granado CardosoEugeni GraugésElena GraveriniLuke GrazetteGiacomo GrazianiAlexandru Tudor GrecuNathan Allen GrieserLucia GrilloSergey GromovChenxi GuMarco GuariseLaetitia GuerryAbdul-Kerim GuseinovEvgeny GushchinYury GuzThierry GysKai Sebastian HabermannThomas HadavizadehChristos HadjivasiliouGuido HaefeliChristophe HaenSamuel James HakenGeorge HallettPhoebe Meredith HamiltonJan HammerichQundong HanXiaoxue HanStephanie Hansmann-MenzemerLei HaoNeville HarnewThomas James HarrisMarie HartmannSabin HashmiJibo HeNathan Barry HeatleyAndreea-Irina HedesFrederic HemmerConor HendersonRaoul HendersonRiley Dylan Leslie HendersonArthur Marius HennequinKarol HennessyLouis HenryJames Daniel HerdPaula Herrero GasconJohannes HeuelAnna-Maria HeynAdlène HicheurGuillermo Hijano MendizabalJoshua Ethan HorswillRuiwen HouYingrui HouDylan Cameron HoustonNed Francis HowarthWenhua HuXiaofan HuWouter HulsbergenRoss John HunterMikhail HushchynDavid HutchcroftMarek IdzikDmitrii IlinPhilip IltenAleksandr IniukhinAxel IohnerArtur IshteevKuzma IvshinHendrik JageSergio Javier Jaimes EllesSune JakobsenTomas JakoubekEddy JansBrij Kishor JashalAbolhassan JawaheryChanka JayaweeraVukan JevticZekun JiaEmily Kaiyin JiangXiaojie JiangYi JiangYuyang JiangEsteban Jimenez MoyaNicholas JindalMalcolm JohnAllen Cris John Rubesh RajanDaniel JohnsonChristopher JonesSalil JoshiBeat JostJuan Jose Juan CastellaNathan JurikIzabela JuszczakKamila Karina KalecinskaDimitrios KaminarisSergii KandybeiMichael James KaneYouen KangChandiprasad KarMatthias KaracsonAnni KauniskangasJacob William KautzMichal Krzysztof KazaneckiFloris KeizerMatthew KenzieTjeerd KetelBasem KhanjiAnastasiia KharisovaSergei KholodenkoGaelle KhreichThomas KirnVeronica Soelund KirsebomSuzanne KlaverNico KleijneAlina KleimenovaDenys KlekotsKonrad KlimaszewskiMateusz Rafal KmiecTobias Krischan KnospeRuben KolbSerhii KoliievLars KolkAnatoly KonoplyannikovPawel KopciewiczPatrick KoppenburgAlexander KorchinMikhail KorolevIgor KostiukOleksander KotSofia KotriakhovaElizabeth Marie KowalczykAnastasiia KozachukPolina KravchenkoLeonid KravchukOleg KravcovMichal KrepsPavel KrokovnyWojciech KrupaWojciech KrzemienOleksandr KshyvanskyiSebastian Antoni KubisMarcin KucharczykVasily KudryavtsevEvgenia KulikovaAndrzej KupscVolodymyr KushnirBogdan KutsenkoJakub KvapilIgor KyryllinDaniel LacarrerePaloma Laguarta GonzalezAdriano LaiAndrea LampisDavide LancieriniClara Landesa GomezJohn Jake LaneGaia LanfranchiChristoph LangenbruchJan LangerThomas LathamFederico LazzariCristina LazzeroniRenaud Le GacHo Sang LeeRegis LefèvreAlexander LeflatSergey LegotinMarion LehurauxEdgar Lemos CidOlivier LeroyTadeusz LesiakEzra Douglas LesserBlake LeveringtonAnfeng LiChen LiChing-Hua LiHengne LiJiuzhao LiKechen LiLanxing LiManshu LiPeilian LiPei-Rong LiQinze LiTiange LiTianqi LiYanru LiYiming LiYujie LiZhengchen LianQiming LiangXixin LiangZhihua LiangSimone LibralonAlisha LightbodyChuangxin LinTai-Hua LinRolf LindnerHenry James LintonRoman LitvinovDuanqing LiuFrank Xiangyu LiuGuoming LiuKai LiuShuaiyi LiuWeijie LiuYiming LiuYing LiuYiwei LiuGustavo Alejandro Loachamin OrdonezIsaac Graciano LoboAniol Lobo SalviaAngelo LoiThomas LongFelipe Cesario Laterza LopesJose LopesAlbert Lopez HuertasCristina Lopez IribarnegaraySaúl López SoliñoQiuchan LuChiara LucarelliDonatella LucchesiMiriam Lucio MartinezYiheng LuoAnna LupatoEleonora LuppiKate LynchXiao-Rui LyuGe MaHeng MaSerena MaccoliniFrederic MachefertFlorin 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WildGuy WilkinsonMichael K WilkinsonMike WilliamsMorag Jean WilliamsMark Richard James WilliamsRichard Morgan WilliamsSean James WilliamsZak WilliamsFergus WilsonMichael Andreas WinnWojciech WislickiMariusz WitekLukas WitolaTom WolfElla WoodGuy WormserStephen WottonHangyi WuJie WuXiangyu WuYanxi WuZhenhong WuKenneth WyllieShu XianZhiyu XiangYuehong XieTianyu XingAo XuLiangjun XuMenglin XuZehua XuZhihao XuZijun XuSimran YadavKang YangXueting YangYouhua YangYewon YangZhenwei YangVsevolod YeroshenkoHo Yin Dereck YeungHang YinXiaoyue YinChenxu YuJiesheng YuXuhao YuanYuan YuanJilberto Antonio Zamora SaaMikhail ZavertyaevMilosz ZdybalFrancesco ZenesiniCheng ZengMing ZengChenjia ZhangDongliang ZhangJianyu ZhangLiming ZhangRanyu ZhangShulei ZhangShunan ZhangYanxi ZhangYuge ZhangZhicai ZhangYa ZhaoAlexey ZhelezovShuang ZhengXutao ZhengYangheng ZhengTianwen ZhouXiaokang ZhouYixiong ZhouValeriia ZhovkovskaLinxuan ZhuXianglei ZhuXiaoyu ZhuYibo ZhuValery ZhukovJiahui ZhuoQuan ZouDavide ZulianiGianluca Zunica
• Organismes : Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : The anisotropic flow coefficients $v_n$ quantify the collective medium response to the initial spatial anisotropy of the overlapping region in ion collisions and serve as sensitive probes of both the medium properties and shape of nuclear initial states. In this analysis, the $v_2$ and $v_3$ parameters of prompt charged particles are measured using the multiparticle cumulant method in fixed-target PbNe and PbAr collisions at $\sqrt{s_{NN}} = 70.9$ GeV, collected by LHCb using the SMOG2 gas-target system during the 2024 LHC lead-beam run. The cumulant method is first validated using 2018 PbPb collision data, successfully reproducing previous measurements obtained via the two-particle correlation method. Results for the fixed-target collisions are then presented, showing a significantly larger value of the elliptic flow coefficient $v_2$ in central PbNe with respect to PbAr collisions. This is qualitatively consistent with 3+1D hydrodynamic predictions including ab-initio descriptions of the nuclear structure. The results provide the first experimental confirmation of the distinctive bowling-pin shape of the ground-state $^{20}$Ne nucleus, validating at the same time the hydrodynamic description of the hot medium formed in high-energy collisions involving light ions.

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• Type de publi. : Article dans une revue
• Date de publi. : 04/09/2025
• Auteurs : Manon AllaireElhadji Malick ThiamGuiliana AmaddeoMohamed BouattourJulien EdelineBleuenn BrussetMarianne ZiolPhilippe MerleJean Frédéric BlancThomas UguenNathalie GanneStéphane CattanGhassan RiachiVéronique Loustaud-RattiThomas DecaensChristine SilvainJean Marie PeronAurore BaronGeorges Philippe PageauxFrédéric ObertiRodolphe AntyAlina PascaleSylvain ManfrediMarc BourliereJean Baptiste NousbaumAlexandra HeurgueIsabelle Ollivier-HourmandMarie LequoyJean-Pierre BronowickiAnne Laure VillingGerard DucournauOlivier GanryCharlotte CostentinEric Nguyen-Khac
• Organismes : Centre de recherche sur l'Inflammation CHU Pitié-Salpêtrière [AP-HP] Centre de recherche sur l'Inflammation Hôpital Beaujon [AP-HP] CRLCC Eugène Marquis CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Assistance publique - Hôpitaux de Paris (AP-HP) Service d'Hépatologie [Hôpital de la Croix-Rousse - HCL] Centre Hospitalier Universitaire de Bordeaux Centre National d'Études Spatiales [Toulouse] Hôpital Avicenne [AP-HP] Registre EPIMAD Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Service d'Hépato-Gastroentérologie [CHU Rouen] Université de Rouen Normandie Service de Bactériologie, Virologie, Hygiène [CHU Limoges] Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Universitaire de Toulouse Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi] Centre Hospitalier Universitaire d'Angers Centre méditerranéen de médecine moléculaire Hôpital Paul Brousse CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV
• Publié dans Liver International le 25/10/2020

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Résumé : Background and Aims Atezolizumab–Bevacizumab (AtezoBev) was the first immunotherapy approved for hepatocellular carcinoma (HCC) in France, with initial trials primarily involving patients with viral‐related liver disease. This prospective study aimed to evaluate the efficacy of AtezoBev in a French HCC population predominantly affected by non‐viral liver disease. Methods Data from 545 HCC patients treated with AtezoBev as first‐line systemic therapy were collected from 32 French centres in the CHIEF cohort between July 2020 and January 2023. Kaplan–Meier analysis evaluated overall survival (OS) and progression‐free survival (PFS), while log‐rank tests assessed the impact of baseline characteristics. Results Median age was 69, with 81% Child‐Pugh A and 19% Child‐Pugh B. Liver disease was primarily alcohol‐related (30%) or viral (16%), with mixed aetiology with at least alcohol consumption in 58%. At AtezoBev initiation, 72% of cases were treatment‐naive, 31% were BCLC‐B and 64% were BCLC‐C. Median OS was 23.1 months, with a 12‐month survival rate of 66%. OS was higher in BCLC‐B patients (27.8 months) compared to BCLC‐C (17.2 months, p = 0.0043) and in Child‐Pugh A (26.4 months) compared to Child‐Pugh B (10.6 months, p < 0.001). Median PFS was 5.2 months, with BCLC‐B patients showing significantly longer PFS (6.7 months vs. 3.7 months for BCLC‐C, p = 0.05). Conclusion Real‐world data from the CHIEF cohort demonstrate AtezoBev's effectiveness in a large French HCC population, showing survival and response rates comparable to the IMbrave150 study. These findings validate AtezoBev as effective in routine practice across diverse clinical profiles.

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Fichiers liés : Liver International - 2025 - Allaire - Real‐World Outcomes of Atezolizumab Bevacizumab in Hepatocellular Carcinoma The.pdf

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