Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 04/09/2025
• Auteurs : Manon AllaireElhadji Malick ThiamGuiliana AmaddeoMohamed BouattourJulien EdelineBleuenn BrussetMarianne ZiolPhilippe MerleJean Frédéric BlancThomas UguenNathalie GanneStéphane CattanGhassan RiachiVéronique Loustaud-RattiThomas DecaensChristine SilvainJean Marie PeronAurore BaronGeorges Philippe PageauxFrédéric ObertiRodolphe AntyAlina PascaleSylvain ManfrediMarc BourliereJean Baptiste NousbaumAlexandra HeurgueIsabelle Ollivier-HourmandMarie LequoyJean-Pierre BronowickiAnne Laure VillingGerard DucournauOlivier GanryCharlotte CostentinEric Nguyen-Khac
• Organismes : Centre National d'Études Spatiales [Toulouse] Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques
• Publié dans Liver International le 25/10/2020

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Résumé : ABSTRACT Background and Aims Atezolizumab–Bevacizumab (AtezoBev) was the first immunotherapy approved for hepatocellular carcinoma (HCC) in France, with initial trials primarily involving patients with viral‐related liver disease. This prospective study aimed to evaluate the efficacy of AtezoBev in a French HCC population predominantly affected by non‐viral liver disease. Methods Data from 545 HCC patients treated with AtezoBev as first‐line systemic therapy were collected from 32 French centres in the CHIEF cohort between July 2020 and January 2023. Kaplan–Meier analysis evaluated overall survival (OS) and progression‐free survival (PFS), while log‐rank tests assessed the impact of baseline characteristics. Results Median age was 69, with 81% Child‐Pugh A and 19% Child‐Pugh B. Liver disease was primarily alcohol‐related (30%) or viral (16%), with mixed aetiology with at least alcohol consumption in 58%. At AtezoBev initiation, 72% of cases were treatment‐naive, 31% were BCLC‐B and 64% were BCLC‐C. Median OS was 23.1 months, with a 12‐month survival rate of 66%. OS was higher in BCLC‐B patients (27.8 months) compared to BCLC‐C (17.2 months, p = 0.0043) and in Child‐Pugh A (26.4 months) compared to Child‐Pugh B (10.6 months, p < 0.001). Median PFS was 5.2 months, with BCLC‐B patients showing significantly longer PFS (6.7 months vs. 3.7 months for BCLC‐C, p = 0.05). Conclusion Real‐world data from the CHIEF cohort demonstrate AtezoBev's effectiveness in a large French HCC population, showing survival and response rates comparable to the IMbrave150 study. These findings validate AtezoBev as effective in routine practice across diverse clinical profiles.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 03/09/2025
• Auteurs : Nikola BesicNicolas PicardCédric VégaJean-Pierre RenaudMartin SchwartzMilena PlanellsPhilippe Ciais
• Organismes : Recherche, développement et innovation Commissariat à l'énergie atomique et aux énergies alternatives Centre National de la Recherche Scientifique Université Paris-Saclay Institut Pierre-Simon-Laplace Centre d'études spatiales de la biosphère Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Centre d'études spatiales de la biosphère Centre National de la Recherche Scientifique Commissariat à l'énergie atomique et aux énergies alternatives Institut Pierre-Simon-Laplace Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette]

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Résumé : The development of high resolution mapping models of forest attributes based on employing machine or deep learning techniques has&#160;increasingly accelerated in the last couple of years. The consequence of this is the widespread availability of multiple sources of information, which can either lead to a potential&#160;confusion, or to a possibility to get an "extended&#8221; insight into the state of our forests by interpreting these sources jointly. This contribution aims at addressing the latter, by relying on the Bayesian model averaging (BMA) approach. BMA is a method that can be used in building a consensus from an ensemble of different model predictions. It can be seen as weighted mean of different predictions with weights reflecting the predictive performances of different models, or as a finite mixture model which estimates the probability that each observation from the independent validation dataset has been generated by one of the models belonging to the ensemble. BMA can thus be used to diagnose and understand the difference in the predictions and to possibly interpret them. The predictions in our case are the forest canopy height estimations for the metropolitan France coming from 5 different AI models [1-5], while the independent validation dataset comes from the French National Forest Inventory (NFI) disposing with some 6000 plots per year, distributed across the territory of interest. For every plot we have several measurements/estimations of the forest canopy height out of which the following two are considered in this study: h_m &#8211; the maximum total height (from the tree's base level to the terminal bud of the tree's main stem) measured within the plot, and h_dom &#8211; the average height of the seven largest dominant trees per hectare. In this contribution we present for every considered plot the dominant model with respect to both references i.e. the model having the highest probability to be the one generating measurements/estimations at NFI plot (h_m and h_dom). We present as well as the respective inter-model and the intra-model variance estimations, allowing us to propose a series of hypotheses concerning the established differences between predictions of individual models in function of their specificities. [1] Schwartz, M., et al.: FORMS: Forest Multiple Source height, wood volume, and biomass maps in France at 10 to 30&#8201;m resolution based on Sentinel-1, Sentinel-2, and Global Ecosystem Dynamics Investigation (GEDI) data with a deep learning approach, Earth Syst. Sci. Data, 15, 4927&#8211;4945,&#160;2023, https://doi.org/10.5194/essd-15-4927-2023 [2] Lang, N., et al.: A high-resolution canopy height model of the Earth,&#160;Nat Ecol&#160;Evol&#160;7, 1778&#8211;1789, 2023. https://doi.org/10.1038/s41559-023-02206-6 [3] Morin, D. et al.: Improving Heterogeneous Forest Height Maps by Integrating GEDI-Based Forest Height Information in a Multi-Sensor Mapping Process, Remote Sens.,&#160;14, 2079. 2022, https://doi.org/10.3390/rs14092079 [4] Potapov, P.,&#160;et al.: Mapping global forest canopy height through integration of GEDI and Landsat data, Remote Sensing of Environment, 253, 2021, https://doi.org/10.1016/j.rse.2020.112165. [5] Liu, S.&#160;et al.: The overlooked contribution of trees outside forests to tree cover and woody biomass across Europe, Sci. Adv. 9, eadh4097, 2023, 10.1126/sciadv.adh4097.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 02/09/2025
• Auteurs : Myriam BouichouNicolas GourguechonJulia JourdanPhilippe BertonePierre-Olivier BoyerJean-Phillippe BruasseMarco CappellariStéphanie De CourtoisAngèle DequierJean Ducasse-LapeyrusseXavier HallopeauElisabeth Marie-VictoirePaola Scaramuzza
• Organismes : Laboratoire de recherche des monuments historiques École nationale supérieure d'architecture de Versailles Laboratoire de l'Ecole d'Architecture de Versailles Laboratoire de recherche des monuments historiques École nationale supérieure d'architecture de Versailles Laboratoire de l'Ecole d'Architecture de Versailles Laboratoire de recherche des monuments historiques Laboratoire de recherche des monuments historiques Laboratoire de recherche des monuments historiques École nationale supérieure d'architecture de Versailles Laboratoire de l'Ecole d'Architecture de Versailles

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Guanghui FuLucia NichelliDarío Herrán de la GalaSophie LoizillonCamile BousfihaRomain ValabregueAgusti AlentornKhê Hoang-XuanBertrand MathonCarole SoussainJean-Pierre MarolleauJérôme PaillassaLuc TaillandierPhilippe AgapéAnna SchmittOlivier ChinotGuido AhleDidier DormontCaroline HouillierStéphane LehéricyOlivier Colliot
• Organismes : Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] Institut du Cerveau = Paris Brain Institute Sorbonne Université Equipe Neuroingénierie des systèmes pour modéliser et interfacer les réseaux cérébraux = Systems neuroengineering to model and interface brain networks [ICM Paris] Institut du Cerveau = Paris Brain Institute Instabilité des microsatellites et cancers [CRSA] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut Curie - Saint Cloud CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Centre Hospitalier Universitaire d'Angers Service de Neuro-Oncologie [CHRU Nancy] Centre de Recherche en Automatique de Nancy Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut Bergonié [Bordeaux] Institut de neurophysiopathologie Neuro-Oncologie [Hôpital de la Timone - APHM] Hôpitaux Civils de Colmar Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] Assistance publique - Hôpitaux de Paris (AP-HP) CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris]
• Publié dans Radiology: Imaging Cancer le 05/10/2022

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Résumé : Purpose To develop and validate a deep learning model for automatic segmentation of primary central nervous system lymphoma (PCNSL) at postcontrast T1-weighted MRI. Materials and Methods Data were retrospectively collected from patients with pathologically proven immunocompetent PCNSL between September 2010 and February 2022. Postcontrast T1-weighted MRI scans were used to train and validate a deep learning model based on the nnU-Net framework. Manual segmentation by neuroradiologists served as the reference standard. The model was trained using an internal dataset from a single center and tested on both internal and external test sets from seven additional centers. Performance was assessed using Dice score, mean average surface distance, and F1 score. Statistical comparisons were performed using Mann-Whitney U test and bootstrap resampling for CIs. Results The study included 135 patients (68 female, 66 male, and one of unspecified sex; internal dataset: mean age ±SD, 67.0 years ± 12.0; external dataset: mean age, 75.5 years ± 13.6). The model achieved a mean Dice score of 0.84 (95% CI: 0.79, 0.88) on the internal test set (n = 44) and 0.88 (95% CI: 0.84, 0.91) on the external test set (n = 48), with no evidence of a difference between test sets (P = .59). Performance varied by lesion type; accuracy was highest in homogeneous discrete lesions, and performance was slightly decreased when numerous poorly defined infracentimetric lesions occurred. Strong volumetric correlation was observed between automatic and manual segmentations (internal: r = 0.99, P < .001; external: r = 0.98, P < .001). Conclusion A deep learning model achieved accurate and robust automatic segmentation of PCNSL across multiple clinical centers with different MRI acquisition parameters.

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Fichiers liés : postprint.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/09/2025
• Auteurs : Emilie GovalEmmanuelle AllartPierre AntoinePatrick AugusteJean-Jacques BahainAxel BeauchampPaule CoudretSylvie CoutardAmélie Da CostaKarine Dautel DevreeseRudy DebiakLaurent DeschodtJean-Pierre FagnartPhilippe FerayCaroline FontDavid HérissonDavid KiefferMarina PagliJennifer LantoineJean‑luc LochtOlivier MoineClément ParisJulie PerrotteNoémie SévêqueLuc VallinAudrey Vincent-PennecMarie-Pauline Vignes
• Organismes : Histoire naturelle de l'Homme préhistorique Ministère de la Culture et de la Communication Ministère de la Culture et de la Communication Laboratoire de géographie physique : Environnements Quaternaires et Actuels Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 Histoire naturelle de l'Homme préhistorique Muséum national d'Histoire naturelle Laboratoire de géographie physique : Environnements Quaternaires et Actuels Service départemental d'archéologie du Calvados Institut national de recherches archéologiques préventives Laboratoire de géographie physique : Environnements Quaternaires et Actuels Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène Archéologies et Sciences de l'Antiquité Service départemental d'archéologie du Val d'Oise Palais des Beaux-Arts de Lille Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Laboratoire de géographie physique : Environnements Quaternaires et Actuels Conseil général de la Somme - Centre archéologique départemental Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Centre National de la Recherche Scientifique Archéologies et Sciences de l'Antiquité Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène Institut national de recherches archéologiques préventives Ministère de la Culture et de la Communication Archéologies et Sciences de l'Antiquité Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Laboratoire de géographie physique : Environnements Quaternaires et Actuels Laboratoire de géographie physique : Environnements Quaternaires et Actuels Institut national de recherches archéologiques préventives Archéologies et Sciences de l'Antiquité Université Paris Nanterre Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène GeoArchEon SARL Archéologie et histoire ancienne : Méditerranée - Europe Ministère de la Culture et de la Communication Archéologies et Sciences de l'Antiquité Anthropologie des techniques, des espaces et des territoires au Pliocène et au Pléistocène Paléotime Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 Histoire naturelle de l'Homme préhistorique

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Résumé : Ce rapport se décompose en trois sections, la première rassemble la documentation administrative, la seconde rappelle la problématique générale du projet et présente les résultats obtenus au cours de la triennale 2022-2024, la troisième se compose des annexes. Sauf mention contraire en tête de chapitre les textes et la mise en page sont réalisés par Emilie Goval.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 01/09/2025
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinClaudio QuarantaXiaohu SunDayong WangJin WangHeng YangMingtao ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerZhipeng CuiBolin LiHui WangKai YiJingqing ZhangYuji LiZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouAndreas HadjiagapiouChristos LeonidouCharalambos NicolaouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerEdy AyalaEdgar Carrera JarrinSherif ElgammalAli Ellithi KamelMohammed MahmoudYasser MohammedKarl EhatahtMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalNorman SeebaLaurits TaniAnna MilievaKenneth OsterbergMikko VoutilainenNurfikri Bin NorjoharuddeenErik BrückenFrancisco Ignacio Garcia FuentesPatin InkaewKimmo Tuomas Samuli KallonenRavindra Kumar VermaTapio LampénKati Lassila-PeriniBettina LehtelaSami LehtiTomas LindénNestor Raul Mancilla XintoMikael MyllymäkiMilla-Maarit RantanenSanteri SaariokariNico Timothy ToikkaJorma TuominiemiHenning KirschenmannPanja-Riina LuukkaHenri PetrowMarc BesanconFabrice CoudercMarc DejardinDaniel DenegriPaul DevougeJean-Louis FaureFederico FerriPaul GaigneSerguei GanjourPhilippe GrasGautier Hamel de MonchenaultMintu KumarVictor LohezicJulie MalclesFrancesco OrlandiLouis PortalesSamuele RonchiMehmet Özgür SahinAurore Savoy-NavarroPolina SimkinaMaksym TitovMarta TornagoRuth Amella RanzFlorian BeaudetteGiacomo BoldriniPhilippe BussonClaude CharlotMarco ChiusiTheo Damien CuissetOlivier DavignonAdinda de WitTrisha DebnathIsaac Telford EhleShamik GhoshAndrew GilbertRaphael Granier de CassagnacLida KalipolitiMartina ManoniMatthew NguyenStepan ObraztsovChristophe OchandoRoberto SalernoJean-Baptiste SauvanYves SiroisGamze SokmenLourdes Urda GómezAlexandre ZabiAmina ZghicheJean-Laurent AgramJeremy AndreaDaniel BlochJean-Marie BromEric Christian ChabertCaroline CollardGael CoulonSaskia FalkeUlrich GoerlachRaphael HaeberleAnne-Catherine Le BihanMeena MeenaOceane PoncetGourab SahaPaul VaucelleAdriano Di FlorioDavid AmramStephanie BeauceronBenjamin BlanconGaelle BoudoulNicolas ChanonDidier ContardoPierre DepasseHoumani El MamouniJean FaySusan GasconMaxime GouzevitchChristopher GreenbergGérald GrenierBernard IlleElise Jourd'HuyImad Baptiste LaktinehMorgan LethuillierBenjamin MassoteauLaurent MirabitoArnab PurohitMuriel Vander DoncktJie XiaoGeorge AdamovIrakli LomidzeZviad TsamalaidzeValeria BottaSandra Consuegra RodríguezLutz FeldKatja KleinMartin LipinskiDanilo MeuserPhilipp NattlandVanessa OppenländerAlexander PaulsDanyer Pérez AdánNicolas RöwertMarius TeroerdeCaio DaumannSvenja DiekmannAlena DodonovaNiclas EichDmitry EliseevFrederic EngelkeJohannes ErdmannMartin ErdmannBenjamin FischerThomas HebbekerKerstin HoepfnerFrancesco IvoneAlexander JungNitish KumarMing-Yan LeeFlorian MausolfMarkus MerschmeyerArnd MeyerFabian NowotnyAndrey PozdnyakovWahid RedjebHans ReithlerUttiya SarkarValentina SarkisoviAlexander SchmidtChinmay SethArchana SharmaJan Lukas SpahValentyn VaulinShawn ZaleskiMax Romain BeckersChristian DziwokGünter FlüggeNina HoeflichThomas KressAndreas NowackOliver PoothAchim StahlAlexander ZotzHenriette Aarup PetersenAenne AbelMaria Aldaya MartinJuliette AlimenaSimone AmorosoYing AnIakov AndreevJorn BachSamuel BaxterMaryam BayatmakouHugo Becerril GonzalezOlaf BehnkeAlberto BelvedereFreya BlekmanKerstin BorrasAlan CampbellSuman ChatterjeeLucia Ximena Coll SaraviaGuenter EckerlinDoris EcksteinElisabetta GalloAchim GeiserValentina GuglielmiMoritz GuthoffAndreas HinzmannLaurids JeppeMatthias KasemannClaus KleinwortRoman KoglerMatthias KommDirk KrückerWolfgang LangeDaina Leyva PerniaKuan-Yu LinKaterina LipkaWolfgang LohmannJacopo MalvasoRainer MankelIsabell-Alissandra Melzer-PellmannMikel Mendizabal MorentinAndreas Bernhard MeyerGabriele MilellaKeila Moral FigueroaAndreas MussgillerLakshmi Priya NairJeremi NiedzielaAndreas NürnbergJiwon ParkEvan RankenAlexei RasperezaDaniil RastorguevLovisa RygaardMoritz SchamSimon SchnakePaul SchützeChristian SchwanenbergerDaria SelivanovaKonstantin SharkoMykyta ShchedrolosievDominic StaffordMatin TorkianFederico VazzolerAna Ventura BarrosoRoberval WalshDi WangQun WangKatarzyna WichmannLucas WiensChristoph WissingYewon YangStepan ZakharovAndré Zimermmane Castro SantosAna Rita Alves AndradeMassimiliano AntonelloSven BollwegMatteo BonanomiKarim El MorabitYannick FischerMathis FrahmErika GaruttiAlexander GrohsjeanAyse Asu GuvenliJohannes HallerDaniel HundhausenGregor KasieczkaPhilip KeicherRobert KlannerWilliam KorcariTobias KramerChin-Chia KuoFinn LabeJohannes LangeArtur LobanovLouis MoureauxAliya NigamovaKonstantinos NikolopoulosAlexander PaaschKarla Josefina Pena RodriguezNathan ProuvostTobias QuadfaselBianca RacitiMarcel RiegerDaniel SavoiuPeter SchleperMatthias SchröderJoern SchwandtManuel SommerhalderHartmut StadieGeorg SteinbrückRobert WardBogdan WiederspanMoritz WolfSebastian BrommerErik ButzYi-Mu ChenThorsten ChwalekAlexander DierlammGizem Gul DincerUmut ElicabukNils FaltermannManuel GiffelsArtur GottmannFrank HartmannMaximilian HorzelaFabian HummerUlrich HusemannJan KieselerMarkus KluteRufa Kunnilan Muhammed RafeekOlha LavorykJay Mathew LawhornAdelina LintuluotoStefan MaierMichele MormileThomas MüllerEmanuel PfefferMatteo PresillaGunter QuastKlaus RabbertzBrendan RegneryRalf SchmiederNikita ShadskiyIvan ShvetsovHans-Jürgen SimonisLars SowaLea StockmeierKomal TauqeerMaria TomsBogdan TopkoNicolò TrevisaniCedric VerstegeTim VoigtländerRalf Florian von CubeJost von den DrieschMichael WassmerRoger WolfWolfram Dietrich ZeunerXunwu ZuoGeorgios AnagnostouGeorgios DaskalakisAristotelis KyriakisGeorgios MelachroinosZacharias PainesisIoannis ParaskevasNiki SaoulidouKonstantinos TheofilatosEirini TziaferiEftychia TzovaraKonstantinos VellidisIlias ZisopoulosTheodoros ChatzistavrouGeorgia KarapostoliKonstantinos KousourisEirini SiamarkouGeorgios TsipolitisIoannis BestintzanosIoannis EvangelouCostas FoudasPanagiotis KatsoulisPanagiotis KokkasPolidamas Georgios Kosmoglou KioseoglouNikolaos ManthosIoannis PapadopoulosJohn StrologasDmitry DruzhkinCsaba HajduDezso HorvathKrisztina MártonAttila József RádlFerenc SiklerViktor VeszpremiMate CsanadKrisztián FarkasAnna FehérkutiMahmod Moussa Abdelkhalek GadallahÁrmin KadlecsikMoisés León CoelloGabriella PasztorGabor Istvan VeresBalazs UjvariGyula ZiliziGyorgy BenczeSandor CzellarJozsef MolnarZoltan SzillasiTamas Ferenc CsorgoFrigyes NemesTamas NovakIstvan SzanyiSunil BansalSuman Bala BeriVipin BhatnagarGeetanjali ChaudharySushil ChauhanNitish DhingraAmandeep KaurAnureet KaurHarjot KaurManjit KaurSunil KumarTanvi SheokandJasbir SinghAayushi SinglaAshutosh BhardwajArjun ChhetriBrajesh C ChoudharyAshok KumarArun 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Résumé : This paper presents a search for a Higgs boson produced in association with a charm quark (cH) which allows to probe the Higgs-charm Yukawa coupling strength modifier $κ_\mathrm{c}$. Higgs boson decays to a pair of W bosons are considered, where one W boson decays to an electron and a neutrino, and the other \PW boson decays to a muon and a neutrino. The data, corresponding to an integrated luminosity of 138 fb$^{-1}$, were collected between 2016 and 2018 with the CMS detector at the LHC at a center-of-mass energy of $\sqrt{s}$ = 13 TeV. Upper limits at the 95% confidence level (CL) are set on the ratio of the measured yield to the standard model expectation for cH production. The observed (expected) upper limit is 1065 (506). When combined with the previous search for cH in the diphoton decay channel of the Higgs boson, the limits are interpreted as observed (expected) constraints at 95% CL on the value of $κ_\mathrm{c}$, $\lvertκ_\mathrm{c}\rvert$ $\lt$ 47 (51).

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Gerhard KindleMickaël AlligonM. AlbertMatthew BucklandJ. David EdgarBenjamin GathmannSujal GhoshAntonios GkantarasAlexandra NietersClaudio PignataPeter N RobinsonStephan RuschCatharina SchuetzS. SharapovaBenjamin ShillitoeFabio CandottiAndrew CantJean‐laurent CasanovaAmos EtzioniAlain FischerIsabelle MeytsLuigi NotarangeloMartine PergentC. SmithDalia Abd ElazizSohilla Lofty M. AbdelkaderAvigaelle AbitbolHassan AbolhassaniLalash AbrahimMohamed AbuzakoukPietro Andrea AccardoNabila Achir MoussouniVeronica AfonsoPhilipp AgyemanMartina AhlmannAlessandro AiutiAbla AklGüzide AksuKim AlbersMeda Diana AlecsandruOlga AleinikovaSvetlana AleshkevichRadwa Salah Eldeen Youssif AlkadyLuis AllendeZoe AllwoodManrique de Lara Laia AlsinaDaniela Ambrosch-BarsoumianLisa AmeshoferKenza AmourEvrim AnadolAriharan AnanthachagaranChantal AndriamangaJulia AndrisKarin AndritschkeFederica AngeliniTobias AnkermannKatrin ApelSiamak AramiÖmür ArdenizPeter ArkwrightKarina ArnoldRudolf AscherlNajla AssamNurit Assia-BatzirFaranaz AtschekzeiSybille AumannVolker AumannMagnus AurivilliusBernd AussererTadej AvcinSezin AydemirEmel Aygören-PürsünCagdas Ayvaz DenizChiara AzzariLo BabacarPerrine BachSophie BachmannPeter BaderShahrzad BakhtiarRenate BancéCatherine BangsKaterina BarfuszSafa BarisB. 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WeemaesJulius WehrleStephan WeidingerMichael WeißElisabeth Weißbarth-RiedelAntje WernerSara WesselMarco WestkemperMonika WicherLutz WickmannSabine WiegertMonique WieheKatharina WiehlerLydia WiesböckEwa Wiesik-SzewczykAnthony WilliamsBeate WinklerChristel WinklerMartina WinklerMelanie WinklerUwe WintergerstLukas WisgrillTorsten WitteHelmut WittkowskiBarbara WolfSandra WölkeChristina WolschnerBeata Wolska-KusnierzPhilip WoodSarita WorkmanAusten WorthMichaela WortmannWalter Alfred WuilleminNico WulffraatKatharina WustrauChloé Wyndham-ThomasOlcay YeginAlisan YildiranDenise YilmazPatrick YoungEsra YucelMilica ZečevićFred ZeppKlaus ZetzscheRainald ZeunerStefan ZielenMartina ZimmermannErić ŽelimirWadih Abou-ChahlaNathalie AladjidiCorinne Armari-AllaVincent BarlogisSophie BayartStéphane BlancheDamien BodetBernard BonnotteRaphaël BoriePatrick BoutardDavid BoutboulClaire BriandetJean-Paul BrionJacques BrouardMartin CastellePascal CathebrasLiana CarausuEmilie CatherinotNathalie CheikhMorgane CheminantThibault ComontLouis-Jean CoudercPierre CougoulAnne DevilleCatherine DevoldereEric DoreFabienne DulieuIsabelle DurieuNatacha Entz-WerléClaire FieschiLionel GalicierVirginie GandemerMartine GardembasClément GourguechonBernard GrosboisAurélien GuffroyCorinne GuittonGaëlle GuillermMohamed HamidouSophie HaroYves HatchuelOlivier HermineCyrille HoarauSébastien HumbertArnaud JaccardJean-Philippe JaisSarah JannierSerge JacquotRoland JaussaudPierre-Yves JeandelEric JeziorskiKamila KebaïliAnne-Sophie KorganowOlivier LambotteFanny LanternierClaire LarrocheDavid LaunayGuillaume Le GuennoEmmanuelle Le MoigneMarc LecuitGuillaume LefèvreJean-Daniel LelièvreRomain LevyValérie Li-Thiao-TeOlivier LortholaryLuminita LucaCoralie MallebrancheMarion MalphettesAude Marie-CardineNicolas Martin-SilvaAgathe MasseauEtienne MerlinFrédéric MillotCharline MiotFloriane MirgotNabila MoussouniLuc MouthonAntoine NéelBénédicte NevenDalila NouarRaphaële Nove-JosserandMarie Ouachée-ChardinAnne PagnierCatherine PaillardMarlène PasquetIsabelle PellierAntoinette PerlatChristophe PiguetDominique PlantazSophie RivièreLoïc RaffrayPascal RoblotPierre-Simon RohrlichBruno RoyerValéry SalleHélène SalvatorFrançoise Sarrot-ReynauldAmélie ServettazJean-Louis StephanNicolas SchleinitzPere Soler PalacínFelipe SuarezLaure SwiaderSophie TaqueCaroline ThomasOlivier TournilhacCaroline ThumerelleJean-Pierre VannierJean-François ViallardMirjam VoellerLisa WegeLennart HammarströmBodo GrimbacherMikko SeppänenNizar MahlaouiStephan EhlMarkus Seidel
• Organismes : French National Reference Center for Primary Immune Deficiencies Hôpital Necker - Enfants Malades [AP-HP] Universitäts Klinikum Freiburg = University Medical Center Freiburg University of Naples Federico II = Università degli studi di Napoli Federico II The Jackson Laboratory for Genomic Medicine Department of Pediatrics and Adolescent Medicine Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Rockefeller University [New York] Human genetics of infectious diseases : Mendelian predisposition Hôpital Necker - Enfants Malades [AP-HP] Howard Hughes Medical Institute Imagine - Institut des maladies génétiques (IHU) Centre de Référence pour les Maladies Rhumatologiques Auto-Immunes et Systémiques [CHU Necker] Collège de France - Chaire Médecine expérimentale (A. Fischer) Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain National Institutes of Health [Bethesda, MD, USA] Karolinska University Hospital [Stockholm] Karolinska Institutet = Karolinska Institute [Stockholm] Karolinska University Hospital [Stockholm] Children’s Medical Center [Tehran, Liban]
• Publié dans Journal of Human Immunity le 24/10/2025

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Résumé : The European Society for Immunodeficiencies patient registry (ESID-R), established in 1994, is one of the world’s largest databases on inborn errors of immunity (IEI). IEI are genetic disorders predisposing patients to infections, autoimmunity, inflammation, allergies, and malignancies. Treatments include antimicrobial therapy, immunoglobulin replacement, immune modulation, stem cell transplantation, and gene therapy. Data from 194 centers in 33 countries capture clinical manifestations and treatments from birth onward, with annually expected updates. This report reviews the ESID-R’s structure, data content, and impact. The registry includes 30,628 patient datasets (aged 0–97.9 years; median follow-up: 7.2 years; total 825,568.2 patient-years), with 13,550 cases in 15 sub-studies. It has produced 84 peer-reviewed publications (mean citation rate: 95). Findings include real-world observations of IEI diagnoses, genetic causes, clinical manifestations, treatments, and survival trends. The ESID-R fosters global collaboration, advancing IEI research and patient care. This report highlights the key role of the multinational ESID-R, led by an independent medical society, in evidence-based discovery.

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