Mycoplasma pneumoniae infection in adult inpatients during the 2023–24 outbreak in France (MYCADO): a national, retrospective, observational study
- Type de publi. : Article dans une revue
- Date de publi. : 19/02/2025
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Auteurs :
Ariane GavaudMatthieu HolubAntoine Asquier-KhatiKarine FaureSophie Leautez-NainvilleGwénaël Le MoalFrançois GoehringerDamien Luque PazBérangère ArnouldVictor GerberGuillaume Martin-BlondelCharles DeclerckSandrine GazaignesSophie BlanchiPaul LoubetNatacha MrozekThomas PerpointMelanie CrestaMorgane MailheAlexandre BleibtreuCharles CazanaveCécile BébéarValérie PourcherFlorence TubachRomain PalichThierry AllègreTimothée Boyer ChammardDelphine PoitrenaudLaura FedericiClaire GiannesiniAudrey MerletThibaut FraisseSalma AbidHanane MehawejAurelien DinhClara DuranAnne-Laure RouxClaire AndréjakDamien BasilleStéphanie DevauxVincent Dubée DubéeThibaud LecerckElisa BernardHelene PailhoriesPaul JaubertStéphane BlancSophie MugnierDorothée VignesCristelle Caruba GuilletAmine BoukraaLéonard CortiMarie DubertRomane PrinShanta ValainathanSixtine ClapinCharlotte WemmertSoline de MonteynardHeloise DelagreverieStephanie BrangerMaminirina Véronique RanaivoarisonMarion TouzetAgnieszka KolakowskaArthur MakaHélène FietteCamille VinclairDavid LeysseneAgnès LefortVictoire de LastoursAntoine HamonLouis BohardCatherine ChirouzeKaty JeannotRaphaël AnxionnatGaël PitonVirginie WesteelStéphane JaureguiberryEmma OliosiGaëlle CuzonVirginie BaltesTiphaine GoulenokNikita DobremelNaouale MaataouiStephane LoQuentin LehingratMichael ThyBertrand LiogerCéline DelerueGuillaume VialLaure BarthodPauline PerreauMathilde PugesPatrick MerciéPierre DuffauNoémie GensousAdissa Tran-MinouiLea PilorgeSimon RollandMarie GousseffYannick FedunTiphaine GuyPierre BarsiAnne CadyMathilde Dupré CoussemacqMarie-Estelle CariouLaure CabaretLaurent d'ArcoMariella Le SauxAurélien Lorleac'HSamuel DeshayesFrédéric RivièreSylvie DargèreBenoit MarthaCatherine François-XavierAurélie FillonBianca PodacLaure ZucciniGuillaume GauthierAmel ChagrinClaudine DesbressesDelphine MartineauMarie BerthomierEman BaharethaLucie GiboldCaroline CharlierAsmaa TaziMarie LachatreElena HoleindreLuc MouthonNicolas RocheMartin MartinotThomas LemmetMathilde WolfAnne-Lise LecapitaineOlivia RaulinAntoine FroissartIrène JarrinMounira SmatiMelinda CheminetValérie ZellerJonathan LondonCécile DevlooBenjamin MembreyPierre-Louis DeclercqJean-Philippe RigaudImane CherfiChristophe LerouxKelian LaskowskiAurélien GouxMaryse Le FlohicAnaïs HébertJulien BuronAlicia HébertCédric CailleLéa TancrayPhilippe MauronNell FauconSusann PéchuzalNatalla RozdolskaMarine AvenelPierre-Alexandre HaussCaroline GateyFrank ChemouniAkim KorchiJeannine IgualAlexandre CurieMohamed MeghadechaMarie BellefleurMarie-Alice ColombierAnnabelle PourbaixCéline GoyardEric FarfourAndré CabiéOrnella CabrasBastien BigeardSylvie AbelVincent RoninFanny QuenardKarine GuitteaudRachid SehouaneRégine BarruetMarwa BachirSafa KhaledAmélie Carrer-CauseretHanaé EssalmiStéphanie CossecAlexandre PonninNastasia El-ZeenniEtienne GarneretJessy CattelanMarie DelfinoOlivier KellerVeronica PrelipceanOlivier VollmerAnne-Claire BertauxAnne-Laure HouistConstance GuillaudJulie ChezelChloé MollièreJulien SchmidtLaurent GilardinAnne-Lise MunierCélia BouchereineRishma AmarsySarah BrodeurFatma HammadFlorence Dangeul-PotierAudrey KaboureAurélie BeaudronKarine BlanckaertFanny VuottoMaureen BrasseurJulien PoissyMarc LambertOlivier LerouzicMarie TitecatAndré LoicBenoît BaillyGaspard GrouteauVanessa LatrySimon AlikMarie DermitPauline Lansalot-MatrasSarah PellerinStéphanie GuyomardAxelle DemaegdtThierry DulacYann LeveneurVictor FranchiPierre OudevilleMarie RamsteinCharlotte KaeufferCorentine AlauzetAnne KennelSandrine HenardNatesan RamsamySimon ValentinFrançois RivièreBenjamin GaboritClara MoraFrançois-Xavier BlancMarianne CosteS. CorvecClarisse DelaunayFanny LanternierElisabete Gomes-PiresAgnès FerroniCamille RogerDany AnglicheauRomaric LarcherAurélie MartinMyriam ChiaruzziFanny VillaAgathe BoudetRobin StephanJulien MazetMélanie LehouxClaire PavinLouis GounelleAlice Jue DenisJustin DestoopWilliam DanjouVincent BérotCécile PouderouxGentiane MonselSamia BoussouarLinda GimenoColine BalcerowiakNaoual QatibCédric VialletteDavid TavelFrance RoblotAgnès Beby-DefauxNicolas LevequeJean-Philippe MartellosioSteven LaurentJulie CelerierVéronique PerronneKarim JaffalLotfi DahmaneChristel Mamona KimluLatifa NoussairLéa PicardKévin DialloPatrice PoubeauRodolphe ManaquinYatrika KoumarFanny AndryAleyya RadjabalyAgathe BounhiolMartin BelanNicolas TraversierArnaud DesvergezAurélie KienlenLudovic LemeeAnaïs LesourdDorothée ChopinDelphine GobertSimon ValayerAki-Julien BabaMarjolaine MorgandPierre FillatreValérie RabierAudrey LamandeAmélie Le GleutMathieu LemoineMarion DollatPierre-Alain BillyFlorian SaunierSylvie PilletElisabeth Botelho-NeversAmandine Gagneux-BrunonNathalie de CastroGuillaume MellonFrançois DanionCoralie Le HyaricPauline DecoursCéline MenardChristelle KoebelLudovic LasselThomas MaitreNausicaa BeaudequinLudovic KarkowskiFabien DutastaOlivier BylickiMarine JolyClément ViguierMaiwenn Nanrocki-PetithommeLaurent CavaliéDamien DuboisFrédéric BalenSandrine CharpentierBéatrice RiuThierry SeguinMarlène MurrisAlain DidierJulien MazièresNassim KamarVincent LarrueAmélie DuréaultCaroline RochasVincent ThomasNancy MarionSandrine BeauchardHélène DurandArmelle PegeotHélène BerthomeLydie GosmeHélène PélerinFabrice CoutierMathilde GrandperrinVincent CailleauxMarion HermetAurélien PiraudAudrey ValdesSenem AltunDorsaf SlamaPauline CarauxCamille CorlouerKevin Gourbeyre MassonTheophile Cocherie
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Organismes :
Institut Pierre Louis d'Epidémiologie et de Santé Publique
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Centre Hospitalier Régional Universitaire [CHU Lille]
Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
Centre Hospitalier Régional Universitaire de Nancy
Hôpital Sud [CHU Rennes]
CHU Rouen
Centre Hospitalier Universitaire [Strasbourg]
Centre Hospitalier Universitaire de Toulouse
Centre Hospitalier Universitaire d'Angers
Centre Hospitalier d'Annecy Genevois
Centre Hospitalier Le Mans (CH Le Mans)
Centre Hospitalier Universitaire de Nîmes
CHU Clermont-Ferrand
Hospices Civils de Lyon
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
CIC Hôpital Bichat
Institut Pierre Louis d'Epidémiologie et de Santé Publique
Centre Hospitalier Universitaire de Bordeaux
Centre Hospitalier Universitaire de Bordeaux
Institut Pierre Louis d'Epidémiologie et de Santé Publique
Institut Pierre Louis d'Epidémiologie et de Santé Publique
Institut Pierre Louis d'Epidémiologie et de Santé Publique
- Publié dans The Lancet Infectious Diseases le 29/10/2020
Résumé : Background. An epidemic of Mycoplasma pneumoniae infection has been observed in France since the fall of 2023. We aimed to: i) describe the characteristics of adults hospitalized for M. pneumoniae infection and ii) identify factors associated with severe outcomes of infection (i.e., intensive care unit [ICU)] admission or in-hospital death).
Methods. MYCADO is a retrospective observational study including adults hospitalized for ≥24 hours in 76 French hospitals for a M. pneumoniae infection between 1 September 2023 and 29 February 2024. Clinical, laboratory and imaging data were collected from medical records.
We identified factors associated with severe outcomes of infection, defined as need for ICU or in-hospital death, using multivariable logistic regression.
Findings. Overall, 1309 patients with M. pneumoniae infection were included: 718 (54.9%) males; median age 43 years (IQR 31-63); 288 (22.0%) with chronic respiratory failure; 423 (32.3%) with cardiovascular comorbidities; 95 (7.3%) with immunosuppression. The most common symptoms were: cough (n=1098, 83.9%), fever (n=1023, 78.2%), dyspnoea (n=948, 72.4%), fatigue (n=550, 42.0%), headache (n=211, 16.1%), arthromyalgia (n=253, 19.3%), vomiting (n=132, 10.1%); 156 (11.9%) patients had extra-respiratory manifestations, including 36 (2.8%) erythema multiforme, 19 (1.5%) meningoencephalitis, 44 (3.4%) autoimmune haemolytic anaemia and 17 (1.3%) myocarditis. The median hospital stay duration was 8 days (IQR 6-11); 415 (31.7%) patients were admitted to ICU and 28 (2.1%) died at hospital. Men, patients with hypertension, obesity, respiratory or liver chronic failure, extra-respiratory manifestations, bilateral lung damage or consolidation on computed tomography scan, elevated inflammatory syndrome, lymphopenia, and those who did not receive any active antibiotic against M. pneumoniae prior to admission, were more likely to present with severe outcomes of infection.
Interpretation. This national, observational study highlights unexpected, atypical radiologic presentations, a high proportion of transfers to ICU, and an association between severity and delayed administration of effective antibiotics.
Fichiers liés :
Mycado_Manuscript_Cleaned_Revision_LID_3.pdf
Source