Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 31/12/2020
• Auteurs : G. DudzińskiE. Podlewska-GacaP. BartczakSelma BenseguaneMarin FerraisL. JordaJosef HanušPierre VernazzaN. RambauxBenoit CarryF. MarchisMichaël MarssetMatti ViikinkoskiM. BrožR. FetickA. DrouardThierry FuscoM. BirlanEmmanuël JehinJérôme BerthierJ. Castillo-RogezFabrice CiprianiF. ColasC. DumasA. KryszczynskaPhilippe LamyH. Le CorollerAlexandre MarciniakT. MichalowskiPatrick MichelToni Santana-RosP. TangaFrédéric VachierArthur ViganOlivier WitasseB. Yang
• Organismes : Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań Astronomical Observatory [Poznan] Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań Astronomical Observatory [Poznan] Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań Astronomical Observatory [Poznan] Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] Institute of Astronomy [Prague] Laboratoire d'Astrophysique de Marseille Institut de Mécanique Céleste et de Calcul des Ephémérides Observatoire de la Côte d'Azur Laboratoire d'Astrophysique de Marseille Search for Extraterrestrial Intelligence Institute Department of Earth, Atmospheric and Planetary Sciences [MIT, Cambridge] University of Tampere [Finland] Institute of Astronomy [Prague] Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Institut de Mécanique Céleste et de Calcul des Ephémérides Astronomical Institute of Romanian Academy Space Sciences, Technologies and Astrophysics Research Institute Institut de Mécanique Céleste et de Calcul des Ephémérides Jet Propulsion Laboratory European Space Research and Technology Centre Institut de Mécanique Céleste et de Calcul des Ephémérides TMT International Observatory Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire d'Astrophysique de Marseille Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań Joseph Louis LAGRANGE Observatoire de la Côte d'Azur Departamento de Fisica, Ingenieria de Sistemas y Teoria de la Señal [Alicante] Institut de Ciencies del Cosmos Observatoire de la Côte d'Azur Institut de Mécanique Céleste et de Calcul des Ephémérides Laboratoire d'Astrophysique de Marseille TMT International Observatory European Southern Observatory [Santiago]
• Publié dans Monthly Notices of the Royal Astronomical Society le 30/10/2020

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Résumé : High angular resolution disc-resolved images of (7) Iris collected by VLT/SPHERE instrument are allowed for the detailed shape modelling of this large asteroid revealing its surface features. If (7) Iris did not suffer any events catastrophic enough to disrupt the body (which is very likely) by studying its topography, we might get insights into the early Solar system's collisional history. When it comes to internal structure and composition, thoroughly assessing the volume and density uncertainties is necessary. In this work, we propose a method of uncertainty calculation of asteroid shape models based on light curve and adaptive optics (AO) images. We apply this method on four models of (7) Iris produced from independent Shaping Asteroids using Genetic Evolution and All-Data Asteroid Modelling inversion techniques and multiresolution photoclinometry by deformation. Obtained diameter uncertainties stem from both the observations from which the models were scaled and the models themselves. We show that despite the availability of high-resolution AO images, the volume and density of (7) Iris have substantial error bars that were underestimated in the previous studies.

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Fichiers liés : staa3153.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/12/2020
• Auteurs : Arnaud GermaneauTanguy VendeuvreAlexandre DelmotteSamuel d'HoutaudCyril BrèqueLouis PetureauPascal DoumalinJ.C. DupréFabrice BrémandPhilippe MaxyJean-Pierre RicherPhilippe Rigoard
• Organismes : Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Robotique, Biomécanique, Sport, Santé [Institut Pprime] Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime] Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime] Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime] Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime] Medtronic SNT ABS Lab – Laboratoire d’Anatomie, Biomécanique et Simulation = ABS Lab – Anatomy Biomechanics Simulation Laboratory Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Photomécanique et analyse expérimentale en mécanique des solides [Institut Pprime]
• Publié dans Clinical Biomechanics le 30/10/2020

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Résumé : BackgroundOccipito-cervical fusion can be necessary in case of cranio-cervical junction instability. Proximal stabilisation is usually ensured by bi-cortical occipital screws implanted through one median or two lateral occipital plate(s). Bone thickness variability as well as the proximity of vasculo-nervous elements can induce substantial morbidity. The choice of site and implant type remains difficult for surgeons and is often empirically based. Given this challenge, implants with smaller pitch to increase bone interfacing are being developed, as is a surgical technique consisting in inverted occipital hook clamps, a potential alternative to plate/screws association. We present here a biomechanical comparison of the different occipito-cervical fusion devices.

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Fichiers liés : S0268003320302928.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/12/2020
• Auteurs : Aymard de LadoucettePatrice MertlMarc-Pierre HenryNicolas BoninPhilippe TracolCyril CourtinJean-Yves Jenny
• Organismes : CHU Amiens-Picardie Centre Hospitalier Régional Universitaire de Brest Institut Pierre Vernier Hôpitaux Universitaires de Strasbourg
• Publié dans Revue de Chirurgie Orthopédique et Traumatologique le 26/10/2020

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Fichiers liés : S1877051720303294.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/12/2020
• Auteurs : Jean-Yves JennyYassine BulaïdPhilippe BoisrenoultNicolas BoninPierre HenkyPhilippe TracolJulien ChouteauCyril CourtinMarc-Pierre HenryClaude SchwartzPatrice MertlAymard de Ladoucette
• Organismes : Hôpitaux Universitaires de Strasbourg CHU Amiens-Picardie Institut Pierre Vernier Centre Hospitalier Régional Universitaire de Brest CHU Amiens-Picardie
• Publié dans Revue de Chirurgie Orthopédique et Traumatologique le 26/10/2020

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Fichiers liés : S1877051720303361.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/12/2020
• Auteurs : Aymard de LadoucettePatrice MertlMarc-Pierre HenryNicolas BoninPhilippe TracolCyril CourtinJean-Yves Jenny
• Organismes : CHU Amiens-Picardie Centre Hospitalier Régional Universitaire de Brest Institut Pierre Vernier Hôpitaux Universitaires de Strasbourg
• Publié dans Orthopaedics & Traumatology: Surgery & Research le 26/10/2020

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Fichiers liés : S1877056820302759.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/12/2020
• Auteurs : Benjamin TerrierRaphaël DarbonCécile-Audrey DurelEric HachullaAlexandre KarrasHélène MaillardThomas PapoXavier PuéchalGrégory PugnetThomas QuemeneurMaxime SamsonCamille TailleLoïc GuillevinVincent AudardOlivier AumaitreKarine BriotPatrice CacoubPascal CathebrasDominique ChauveauOlivier ChosidowLaurent ChouchanaVincent CottinDivi CornecEric DaugasElisabeth DiotNicolas DupinKhalil El KarouiOlivier FainPierre GobertPhilippe GuilpainMohamed HamidouAurélie HummelMarie JachietStéphane JouneauNoémie Jourde ChicheCédric LandronClaire Le JeunneJean‐christophe LegaXavier MarietteNathalie MorelChristian PagnouxPhilippe RemyFrédéric Vandergheynst
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
• Publié dans Orphanet Journal of Rare Diseases le 27/10/2020

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Résumé : Abstract Systemic necrotizing vasculitis comprises a group of diseases resembling polyarteritis nodosa and anti-neutrophil cytoplasmic antibody-associated vasculitis (ANCA): granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. The definitive diagnosis is made in cooperation with a reference center for autoimmune diseases and rare systemic diseases or a competency center. The management goals are: to obtain remission and, in the long term, healing; to reduce the risk of relapses; to limit and reduce the sequelae linked to the disease; to limit the side effects and the sequelae linked to the treatments; to improve or at least maintain the best possible quality of life; and to maintain socio-professional integration and/or allow a rapid return to school and/or professional activity. Information and therapeutic education of the patients and those around them are an integral part of the care. All health professionals and patients should be informed of the existence of patient associations. The treatment of vasculitis is based on variable combinations of glucocorticoids and immunosuppressants, chosen and adapted according to the disease concerned, the severity and/or extent of the disease, and the underlying factors (age, kidney function, etc.). Follow-up clinical and paraclinical examinations must be carried out regularly to clarify the progression of the disease, detect and manage treatment failures and possible relapses early on, and limit sequelae and complications (early then late) related to the disease or treatment. A distinction is made between the induction therapy, lasting approximately 3–6 months and aimed at putting the disease into remission, and the maintenance treatment, lasting 12–48 months, or even longer. The role of the increase or testing positive again for ANCA as a predictor of a relapse, which has long been controversial, now seems to have greater consensus: Anti-myeloperoxidase ANCAs are less often associated with a relapse of vasculitis than anti-PR3 ANCA.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/12/2020
• Auteurs : Elisabet ViaynaNicolas CoquelleMonika Cieslikiewicz-BouetPedro CisternasCarolina OlivaElena Sánchez-LópezMiren EttchetoManuela BartoliniAngela de SimoneMattia RicchiniMarisa RendinaMégane PonsOmidreza FiruziBelén PérezLuciano SasoVincenza AndrisanoFlorian NachonXavier BrazzolottoMaria Luisa GarcíaAntoni CaminsIsrael SilmanLudovic JeanNibaldo InestrosaJacques-Philippe ColletierPierre-Yves RenardDiego Muñoz-Torrero
• Organismes : Institut de biologie structurale Chimie Organique et Bioorganique : Réactivité et Analyse Institut de biologie structurale
• Publié dans Journal of Medicinal Chemistry le 25/10/2020

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Fichiers liés : 705872.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/12/2020
• Auteurs : Paul GiraudPhilippe GiraudEliot NicolasPierre BoisselierMarc AlfonsiMichel RivesEtienne BardetValentin CalugaruGeorges NoelEnrique ChajonPascal PommierMagali MorelleLionel PerrierXavier LiemAnita BurgunJean-Emmanuel Bibault
• Organismes : Health System Analysis Laboratory
• Publié dans Cancers le 21/10/2020

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Résumé : Background: There is no evidence to support surgery or radiotherapy as the best treatment for resectable oropharyngeal cancers with a negative HPV status. Predictive algorithms may help to decide which strategy to choose, but they will only be accepted by caregivers and European authorities if they are interpretable. As a proof of concept, we developed a predictive and interpretable algorithm to predict locoregional relapse at 18 months for oropharyngeal cancers as a first step towards that goal. Methods: The model was based on clinical and Pyradiomics features extracted from the dosimetric CT scan. Intraclass correlation was used to filter out features dependant on delineation. Correlated redundant features were also removed. An XGBoost model was cross-validated and optimised on the HN1 cohort (79 patients), and performances were assessed on the ART ORL cohort (45 patients). The Shapley Values were used to provide an overall and local explanation of the model. Results: On the ART ORL cohort, the model trained on HN1 yielded a precision—or predictive positive value—of 0.92, a recall of 0.42, an area under the curve of the receiver operating characteristic of 0.68 and an accuracy of 0.64. The most contributory features were shape Voxel Volume, grey level size zone matrix Small Area Emphasis (glszmSAE), gldm Dependence Non Uniformity Normalized (gldmDNUN), Sex and Age. Conclusions: We developed an interpretable and generalizable model that could yield a good precision—positive predictive value—for relapse at 18 months on a different test cohort.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/12/2020
• Auteurs : Valentin CalugaruPascal PommierPaul GiraudPhilippe GiraudEliot NicolasPierre BoisselierMarc AlfonsiMichel RivesEtienne BardetGeorges NoelEnrique ChajonMagali MorelleLionel PerrierXavier LiemAnita BurgunJean Emmanuel Bibault
• Organismes : Institut Curie [Paris] Centre Léon Bérard [Lyon] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Institut de Recherche en Cancérologie de Montpellier Institut Sainte Catherine [Avignon] Oncopole Claudius Regaud CRLCC René Gauducheau Laboratoire Traitement du Signal et de l'Image Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP]
• Publié dans Cancers le 21/10/2020

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Résumé : Background: There is no evidence to support surgery or radiotherapy as the best treatment for resectable oropharyngeal cancers with a negative HPV status. Predictive algorithms may help to decide which strategy to choose, but they will only be accepted by caregivers and European authorities if they are interpretable. As a proof of concept, we developed a predictive and interpretable algorithm to predict locoregional relapse at 18 months for oropharyngeal cancers as a first step towards that goal. Methods: The model was based on clinical and Pyradiomics features extracted from the dosimetric CT scan. Intraclass correlation was used to filter out features dependant on delineation. Correlated redundant features were also removed. An XGBoost model was cross-validated and optimised on the HN1 cohort (79 patients), and performances were assessed on the ART ORL cohort (45 patients). The Shapley Values were used to provide an overall and local explanation of the model. Results: On the ART ORL cohort, the model trained on HN1 yielded a precision—or predictive positive value—of 0.92, a recall of 0.42, an area under the curve of the receiver operating characteristic of 0.68 and an accuracy of 0.64. The most contributory features were shape Voxel Volume, grey level size zone matrix Small Area Emphasis (glszmSAE), gldm Dependence Non Uniformity Normalized (gldmDNUN), Sex and Age. Conclusions: We developed an interpretable and generalizable model that could yield a good precision—positive predictive value—for relapse at 18 months on a different test cohor

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Fichiers liés : cancers-13-00057.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/12/2020
• Auteurs : Rabih AboukaïsAntoine DevalckeneerPierre BoussemartAmélie VromantNicolas BricoutMarie-François VerdinPhilippe BourgeoisCédric CireneiPatrick GoldsteinBenoit TavernierXavier LeclercJean-Paul LejeuneJean-Philippe Boussemart
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Services de neuroradiologie [Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 Lille économie management - UMR 9221
• Publié dans Clinical Neurology and Neurosurgery le 30/10/2020

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Résumé : Background/objectives The present study aimed at evaluating the impact on the early outcome of patients with ruptured intracranial aneurysms. Methods Our study prospectively included 26 consecutive patients with ruptured intracranial aneurysm managed at our institution in context of COVID-19 pandemic between March 1st, 2020 and April, 26th, 2020 (2020 group). A group control included other 28 consecutive patients managed at the same institution for the same disease in 2019, during the same time frame (2019 group). On admission, poor neurological status was defined as WFNS score >3. Severe radiological status was defined by the presence of intracerebral hematoma, or/and acute hydrocephalus requiring further EVD or/and the presence of vasospasm on presentation. Statistical analysis was performed to compare the 2 distinct groups. Results Rates of poor neurological presentation and severe radiological presentation on hospital admission were higher in the 2020 group (p = 0.01 and p = 0.02, respectively). The delayed hospital admission was 2.7 days in 2020 group and 0.75 days in 2019 group (p = 0.005). Therefore, vasospasm’s rate on presentation was also higher in the 2020 group (p = 0.04). Conclusion To our knowledge, this is one of the first studies demonstrating influence of the COVID-19 pandemic on patients with urgent and severe intracranial aneurysmal disease. In case of recurrent COVID-19 pandemic, educating the population concerning specific symptoms such as sudden headache, neurological deficit or even sudden chest pain should be emphasized.

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