Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 24/12/2020
• Auteurs : Marie LegendreAfifaa ButtRaphaël BorieMarie-Pierre DebrayDiane BouvryEmilie Filhol-BlinTifenn DesroziersValérie NAUBruno CopinFlorence Dastot - Le MoalMélanie HéryPhilippe DuquesnoyNathalie AllouAnne BergeronJulien BermudezAurélie CazesAnne-Laure ChénéVincent CottinBruno CrestaniJean-Charles DalphinChristine DombretBérénice DorayClairelyne DupinViolaine GiraudAnne GondouinLaurent GouyaDominique Israël-BietCaroline KannengiesserAurélie Le BorgneSylvie LeroyElisabeth LongchamptGwenaël LorillonHilario NunesClément PicardMartine Reynaud-GaubertJulie TracletPaul de VuystAurore Coulomb-L'HermineAnnick ClémentSerge AmselemNadia Nathan
• Organismes : Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires Hôpital Avicenne [AP-HP] CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique Maladies génétiques d'expression pédiatrique Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion] Hopital Saint-Louis [AP-HP] Hôpital Nord [CHU - APHM] Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hospices Civils de Lyon Université Claude Bernard Lyon 1 AP-HP - Hôpital Bichat - Claude Bernard [Paris] Laboratoire Chrono-environnement (UMR 6249) Centre Hospitalier Régional Universitaire de Besançon AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion] Hopital Saint-Louis [AP-HP] Hôpital Ambroise Paré [AP-HP] Laboratoire Chrono-environnement (UMR 6249) Centre Hospitalier Régional Universitaire de Besançon Hopital Saint-Louis [AP-HP] Hôpital Européen Georges Pompidou [APHP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire de Toulouse Hôpital Pasteur [Nice] Hôpital Foch [Suresnes] Hopital Saint-Louis [AP-HP] Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires Hôpital Avicenne [AP-HP] Hôpital Foch [Suresnes] Hôpital Nord [CHU - APHM] Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Hospices Civils de Lyon Université Claude Bernard Lyon 1 Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP]
• Publié dans European Respiratory Journal le 23/10/2020

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Résumé : Introduction Interstitial lung diseases (ILDs) can be caused by mutations in the SFTPA1 and SFTPA2 genes, which encode the surfactant protein (SP) complex SP-A. Only 11 SFTPA1 or SFTPA2 mutations have so far been reported worldwide, of which five have been functionally assessed. In the framework of ILD molecular diagnosis, we identified 14 independent patients with pathogenic SFTPA1 or SFTPA2 mutations. The present study aimed to functionally assess the 11 different mutations identified and to accurately describe the disease phenotype of the patients and their affected relatives. Methods The consequences of the 11 SFTPA1 or SFTPA2 mutations were analysed both in vitro , by studying the production and secretion of the corresponding mutated proteins and ex vivo , by analysing SP-A expression in lung tissue samples. The associated disease phenotypes were documented. Results For the 11 identified mutations, protein production was preserved but secretion was abolished. The expression pattern of lung SP-A available in six patients was altered and the family history reported ILD and/or lung adenocarcinoma in 13 out of 14 families (93%). Among the 28 SFTPA1 or SFTPA2 mutation carriers, the mean age at ILD onset was 45 years (range 0.6–65 years) and 48% underwent lung transplantation (mean age 51 years). Seven carriers were asymptomatic. Discussion This study, which expands the molecular and clinical spectrum of SP-A disorders, shows that pathogenic SFTPA1 or SFTPA2 mutations share similar consequences for SP-A secretion in cell models and in lung tissue immunostaining, whereas they are associated with a highly variable phenotypic expression of disease, ranging from severe forms requiring lung transplantation to incomplete penetrance.

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Fichiers liés : Revision_Nathan_SPA_main_manuscript_1507 (1).pdf

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• Type de publi. : Rapport
• Date de publi. : 23/12/2020
• Auteurs : Jean Ulrich MullotChristian GauvritMarc BardinEnrique BarriusoPhilippe BernyM.-F. Corio-CostetJean-Pierre CugierMarc GallienSonia GrimbuhlerGuillermina Hernandez-RaquetFrançois LaurentLaure MamyPatrick SaindrenanJeanne Stadler
• Organismes : Service de Santé des Armées Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Unité de Pathologie Végétale Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement Santé et agroécologie du vignoble Retraité Information – Technologies – Analyse Environnementale – Procédés Agricoles Toulouse Biotechnology Institute Métabolisme et Xénobiotiques Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes Retraité Retraité

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Résumé : En 2020, les cultures de betteraves sucrières ont été fortement impactées par la présence de pucerons vecteurs de jaunisse. Dans ce contexte, le Gouvernement a présenté un projet de loi autorisant les ministres chargés de l’agriculture et de l’environnement à déroger, sur le fondement de l’article 53 du règlement (CE) N°1107/2009, jusqu’au 1er juillet 2023, à l’interdiction d’utilisation de semences traitées avec des produits contenant des néonicotinoïdes ou des substances présentant un mode d’action identique.Il est demandé à l’Anses de préciser les mesures d’atténuation des risques de dissémination dans l’environnement et d’effets néfastes sur les organismes non cibles, en particulier les insectes pollinisateurs et les oiseaux, concernant la culture issue de semences traitées mais également les cultures suivantes, qui devraient figurer dans la dérogation. Le cas échéant, l’Anses devra indiquer si ces mesures devraient être différentes selon la substance et la dose utilisée. Dans le cadre de l’octroi de dérogation (article 53 du règlement (CE) N° 1107/2009) plusieurs Etats membres ont instauré des mesures de gestion concernant les cultures suivantes. L’Anses devra identifier celles qui pourraient être retenues en France compte tenu des pratiques de rotations culturales les plus fréquentes. Il faudra également prendre en compte dans cette analyse la mise en place d’une culture intermédiaire broyée avant floraison après la culture suivante.L’analyse de l’Anses portera sur les effets néfastes sur les insectes pollinisateurs1 et les oiseaux, relatifs aux produits contenant des néonicotinoïdes, qui bénéficiaient, avant leur interdiction, d’une AMM en France pour un usage en traitement de semences de betteraves pour lutter contre les pucerons. Elle prendra en compte l’usage et les conditions d’emploi revendiquées lors de ces autorisations de mise sur le marché (AMM) ainsi que les évaluations de risque conduites par l’EFSA pour les substances de la famille des néonicotinoïdes et en particulier celles publiées en 2018 concernant les pollinisateurs, et celles publiées en 2014 concernant les oiseaux.Les produits autorisés en France pour cet usage avant l’interdiction étaient des produits contenant de l’imidaclopride ou du thiaméthoxame. Pour l’imidaclopride, la dose maximale autorisée était de 127,4 g s.a/ha (soit 0,13 kg/unité pour Nuprid 70; 1,4 unité/ha). Pour le thiaméthoxame, la dose maximale autorisée était de 84 g s.a/ha (soit 0,1 L/unité pour Cruiser 600 FS; 1,4 unité/ha). L’analyse intègrera également la clothianidine, substance active de la famille des néonicotinoïdes qui est un métabolite du thiaméthoxame.

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• Type de publi. : Article dans une revue
• Date de publi. : 21/12/2020
• Auteurs : Jean-Pierre LandesmanMarc FouchierErwine PargonSolène GérardNévine RochatChristophe LevalloisMerwan MokhtariPhilippe Pagnod-RossiauxFrançois LaruelleCamille Petit-EtienneMauro BettiatiJuan JimenezDaniel T Cassidy
• Organismes : Institut des Fonctions Optiques pour les Technologies de l'informatiON Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Institut de Physique de Rennes Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Institut des Fonctions Optiques pour les Technologies de l'informatiON Institut de Physique de Rennes 3SP Technologies 3SP Technologies Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information 3SP Technologies Universidad de Valladolid [Valladolid] McMaster University [Hamilton, Ontario]
• Publié dans Journal of Applied Physics le 02/11/2020

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Résumé : The mechanical deformation induced by reactive ion etching (RIE) of rectangular ridge waveguides in GaAs and InP has been investigated by photoluminescence and cathodoluminescence techniques. Several trends were identified and are discussed. First, it is concluded that the RIE process itself is the source of the mechanical deformation. A compressive volume change occurs mainly within the ridge (with a maximum close to the vertical etched sidewalls), extending outside the ridges, up to several micrometers below the bottom etched surface. An anisotropic deformation also appears, again mainly close to the etched sidewalls and below the bottom etched surface. A narrow area under tensile stress was also identified, localized outside the ridges and in a shallow region below the bottom etched surface. Cumulative, overlapping effects are seen inside the ridges where the compressive stress fields originating at the vertical etched sidewalls contribute to an overall compression inside the ridge which increases as the ridge width decreases. In addition, a tensile stress is also observed outside the ridge, strongly enhanced by the presence of neighboring ridges. These conclusions are significant for the design of photonic structures. Because of the photoelastic effect, which is important in GaAs and InP, the properties of devices such as waveguides might be affected by the mechanical stress described herein.

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Fichiers liés : Landesman_et_al_JAP_v02.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/12/2020
• Auteurs : Theodora OikonomidiIsabelle BoutronOlivier PierreGuillaume CabanacPhilippe H. RavaudCovid-19 Nma Consortium
• Organismes : Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Cochrane France Hôpital Hôtel-Dieu [Paris] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Cochrane France Hôpital Hôtel-Dieu [Paris] Cochrane France Hôpital Hôtel-Dieu [Paris] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Recherche d’Information et Synthèse d’Information Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Cochrane France Columbia Mailman School of Public Health Hôpital Hôtel-Dieu [Paris]
• Publié dans BMC Medicine le 01/11/2020

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Résumé : Background: The increasing use of preprints to disseminate evidence on the effect of interventions for the coronavirus disease 2019 (COVID-19) can lead to multiple evidence sources for a single study, which may differ in the reported evidence. We aim to describe the proportion of evidence on the effect of interventions for COVID-19 from preprints and journal articles and map changes in evidence between and within different sources reporting on the same study. Methods: Meta-research study. We screened the Cochrane living systematic review and network meta-analysis (COVID-NMA) database to identify all preprints and journal articles on all studies assessing interventions for COVID-19 published up to 15 August 2020. We compared all evidence sources (i.e., preprint and associated journal article) and the first and latest versions of preprints for each study to identify changes in two evidence components: study results (e.g., numeric change in hazard ratio, odds ratio, event rate, or change in p value > or < 0.05 in any outcome) and abstract conclusions (classified as positive, negative or neutral regarding the intervention effect, and as reporting uncertainty in the findings or not). Changes in study results were further classified as important changes if they (1) represented a change in any effect estimate by ≥ 10% and/or (2) led to a change in the p value crossing the threshold of 0.05.Results: We identified 556 studies. In total, 338 (61%) had been reported in a preprint: 66 (20%) of these had an associated journal article (median time to publication 76 days [interquartile range (IQR) 55-106]) and 91 (27%) had > 1 preprint version. A total of 139 studies (25% of the overall sample) were reported in multiple evidence sources or versions of the same source: for 63 (45%), there was a change in at least one evidence component between or within sources (42 [30%] had a change in study results, and in 29 [21%] the change was classified as important; 33 [24%] had a change in the abstract conclusion). For studies with both a preprint and an article, a median of 29% (IQR 14-50) of total citations were attributed to the preprint instead of the article.Conclusions: Results on the effect of interventions for COVID-19 are often reported in multiple evidence sources or source versions for a single study. Evidence is not stable between and within evidence sources. Real-time linkage of all sources per study could help to keep systematic reviews up-to-date.

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Fichiers liés : OikonomidiEtAl2020.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/12/2020
• Auteurs : Gregoire RangéChristophe Saint EtiennePierre MarcolletStephan ChassaingPhilippe DequenneRadwan HakimJean CapsecChristophe LaureSandra GautierFranck AlbertLucile GodillonPelle StoltPascal MotreffLeslie Grammatico-GuillonMehmet Akif KaramercanZerrin Defne DündarOene van MeerRichard BodyVeli-Pekka HarjolaFranck VerschurenMichael ChristAdela GoleaCinzia BarlettaLuis Garcia-CastrilloYusuf Ali AltunciYavuz KatirciAnne-Maree KellySaid Laribi
• Organismes : Hôpital Louis Pasteur [Chartres] CHU Trousseau [Tours] Centre Hospitalier Jacques Coeur [Bourges] Clinique Saint Gatien Hôpitaux de Chartres [Chartres] Éducation Éthique Santé Hôpitaux de Chartres [Chartres] Maglia Rotta Institut Pascal Centre Hospitalier Régional Universitaire de Tours Helsingin yliopisto = Helsingfors universitet = University of Helsinki Emergency Department
• Publié dans Turkish Journal of Medical Sciences le 01/11/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/12/2020
• Auteurs : Farid SalehRomain VaucherJonathan B AntcliffeAllison C DaleyKhadija El HaririKhaoula KouraissBertrand LefebvreEmmanuel Laurent Olivier MartinJean-Philippe PerrillatPierre Sans-JofreMuriel VidalBernard Pittet
• Organismes : Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement

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Résumé : The Fezouata Biota in Morocco is the only Lower Ordovician Lagerstätte yielding a biologically diverse assemblage in a fully marine environment, whilst also containing organisms typical of Cambrian Burgess Shale-type (BST) ecosystems. Fossils from the Fezouata Shale share the same mode of preservation as Cambrian BST biotas defined by carbonaceous compressions and accessory authigenic mineralization. Most organisms of the Fezouata Biota were already dead and decaying on the seafloor when they were buried in situ by occasional storm deposits in a distal facies. Pre-burial decay in the Fezouata Shale was responsible for the non-preservation of completely cellular organisms such as jellyfish. These conditions contrast with the processes described for soft-tissue preservation in the Burgess Shale (Canada) and the Chengjiang biota (China). In these two Cambrian Lagerstätten, animals were transported alive or shortly after death by obrution events to a facies that was favourable for preservation. Despite preservational biases, the autochthonous assemblages of the Fezouata Shale offer a unique opportunity to decipher the structure of in situ communities and ecological dynamics in Early Palaeozoic seas, when compared to the allochthonous communities of most Cambrian BST biotas

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• Type de publi. : Article dans une revue
• Date de publi. : 15/12/2020
• Auteurs : Joana VitteAïssatou Bailo DialloAsma BoumazaAlexandre LopezMoïse MichelJerome Allardet-ServentSoraya MezouarYoussouf SeremeJean-Marc BusnelTewfik MiloudFabrice MalerguePierre-Emmanuel MorangePhilippe HalfonDaniel OliveMarc LeoneJean-Louis Mège
• Organismes : Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Aix-Marseille Université - École de médecine Microbes Evolution Phylogénie et Infections CHU Marseille Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Beckman Research Institute [Duarte, CA] Beckman Research Institute [Duarte, CA] Beckman Research Institute [Duarte, CA] Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Hôpital Européen [Fondation Ambroise Paré - Marseille] Centre de Recherche en Cancérologie de Marseille Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans Journal of Infectious Diseases le 27/10/2020

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Résumé : Background An unbiased approach to SARS-CoV-2–induced immune dysregulation has not been undertaken so far. We aimed to identify previously unreported immune markers able to discriminate COVID-19 patients from healthy controls and to predict mild and severe disease.Methods An observational, prospective, multicentric study was conducted in patients with confirmed mild/moderate (n = 7) and severe (n = 19) COVID-19. Immunophenotyping of whole-blood leukocytes was performed in patients upon hospital ward or intensive care unit admission and in healthy controls (n = 25). Clinically relevant associations were identified through unsupervised analysis.Results Granulocytic (neutrophil, eosinophil, and basophil) markers were enriched during COVID-19 and discriminated between patients with mild and severe disease. Increased counts of CD15+CD16+ neutrophils, decreased granulocytic expression of integrin CD11b, and Th2-related CRTH2 downregulation in eosinophils and basophils established a COVID-19 signature. Severity was associated with emergence of PD-L1 checkpoint expression in basophils and eosinophils. This granulocytic signature was accompanied by monocyte and lymphocyte immunoparalysis. Correlation with validated clinical scores supported pathophysiological relevance.Conclusions Phenotypic markers of circulating granulocytes are strong discriminators between infected and uninfected individuals as well as between severity stages. COVID-19 alters the frequency and functional phenotypes of granulocyte subsets with emergence of CRTH2 as a disease biomarker.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/12/2020
• Auteurs : Philippe Dugot
• Organismes : Laboratoire Interdisciplinaire Solidarités, Sociétés, Territoires
• Publié dans Sud-Ouest Européen le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 15/12/2020
• Auteurs : Anna CastriotoStéphane ThoboisMathieu AnheimJean-Louis QuesadaEugénie LhomméeHélène KlingerAmélie BichonEmmanuelle SchmittFranck DurifJean-Philippe AzulayJean-Luc HouetoNadine LongatoC. PhilippsPierre PelissierEmmanuel BroussolleElena MoroChristine TranchantValérie FraixPaul Krack
• Organismes : Institut de Génétique et de Biologie Moléculaire et Cellulaire Institut de génétique et biologie moléculaire et cellulaire Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie Institut de génétique et biologie moléculaire et cellulaire Institut de Génétique et de Biologie Moléculaire et Cellulaire
• Publié dans npj Parkinson's Disease le 14/02/2020

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Résumé : Management of apathy, depression and anxiety in Parkinson's disease (PD) represents a challenge. Dopamine agonists have been suggested to be effective. This multicenter, randomized (1:1), double-blind study assessed the 6-month effect of rotigotine versus placebo on apathy, depression and anxiety in de novo PD. The primary outcome was the change of apathy, measured with the LARS. The secondary outcomes were the change in depression and anxiety, measured with BDI-2 and STAI-trait and state. Forty-eight drug-naive PD patients were included. The primary outcome was not reached, with a surprisingly high placebo effect on apathy (60%). There was no significant difference in the change of depression at 6 months between rotigotine and placebo. Trait-anxiety was significantly improved by rotigotine compared to placebo (p = 0.04). Compared to placebo, low dose rotigotine significantly improved trait anxiety, but not apathy and depression. The major placebo effect on apathy points towards the importance of a multidisciplinary and tight follow-up in the management of neuropsychiatric symptoms.

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Fichiers liés : islandora_152349.pdf

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• Type de publi. : Autre publication
• Date de publi. : 15/12/2020
• Auteurs : Guillaume E PorrazJohn E. ParkingtonPatrick SchmidtGerald BereiziatJean-Philip BrugalLaure DayetMarina IgrejaChristopher E MillerViola SchmidChantal TriboloAurore ValChristine VernaPierre-Jean Texier
• Organismes : Laboratoire méditerranéen de préhistoire Europe-Afrique University of the Witwatersrand [Johannesburg] University of Cape Town Eberhard Karls Universität Tübingen = University of Tübingen De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Laboratoire méditerranéen de préhistoire Europe-Afrique Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Centro de Investigação em Biodiversidade e Recursos Genéticos [Vairao] Eberhard Karls Universität Tübingen = University of Tübingen Eberhard Karls Universität Tübingen = University of Tübingen Institut de Recherches sur les Archéomatériaux Eberhard Karls Universität Tübingen = University of Tübingen Histoire naturelle de l'Homme préhistorique Laboratoire méditerranéen de préhistoire Europe-Afrique
• Publié dans Peer Community Journal le 26/11/2021

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Résumé : In southern Africa, key technologies and symbolic behaviors develop as early as the later Middle Stone Age in MIS5. These innovations arise independently in various places, contexts and forms, until their full expression during the Still Bay and the Howiesons Poort. The Middle Stone Age sequence from Diepkloof Rock Shelter, on the West Coast of the region, preserves archaeological proxies that help unravelling the cultural processes at work. This unit yields one of the oldest abstract engraving so far discovered in Africa, in the form of a rhomboid marking on the cortical surface of an ungulate long bone shaft. The comprehensive analysis of the lithic artefacts and ochre pieces found in association with the engraved bone documents the transport of rocks over long distance (>20km), the heat treatment of silcrete, the coexistence of seven lithic reduction strategies (including the production of bladelets and the manufacture of unifacial and bifacial points), the use of adhesives and the processing of ochre. At Diepkloof, the appearance of engraving practices take place in a context that demonstrates a shift in rock procurement and a diversification in lithic reduction strategies, suggesting that these behavioral practices acted as a cultural answer to cope with new environmental and/or socioeconomic circumstances. We argue that the innovations later found during the Still Bay and the Howiesons Poort were already in the making during the MIS5 pre-Still Bay, though not all the benefits were yet taken advantage of by the populations.

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Fichiers liés : PORRAZ_AL_2021_PCJ.pdf

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