Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Benjamin TerrierRaphaël DarbonCécile-Audrey DurelÉric HachullaAlexandre KarrasHélène MaillardThomas PapoXavier PuéchalGrégory PugnetThomas QuéméneurMaxime SamsonCamille TailleLoïc GuillevinVincent AudardOlivier AumaîtreKarine BriotPatrice CacoubPascal CathébrasDominique ChauveauOlivier ChosidowLaurent ChouchanaVincent CottinDivi Yk CornecEric DaugasElisabeth DiotNicolas DupinKhalil El KarouiOlivier FainPierre GobertPhilippe GuilpainMohamed HamidouAurelie HummelMarie JachietStephane JouneauNoémie Jourde-ChicheCédric LandronClaire Le JeunneJean‐christophe LegaXavier MarietteNathalie MorelChristian PagnouxPhilippe RemyFrederic Vandergheynst
• Organismes : Service de médecine interne et centre de référence des maladies rares [CHU Cochin] Association France Vascularites [Paris] Hospices Civils de Lyon Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Service de Néphrologie et Hémodialyse [CHU HEGP] Centre Hospitalier Régional Universitaire [CHU Lille] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Service de médecine interne et centre de référence des maladies rares [CHU Cochin] Centre Hospitalier Universitaire de Toulouse Centre hospitalier [Valenciennes, Nord] Service de Médecine Interne (SOC 1 et SOC 2) [CHU de Dijon] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Service de médecine interne et centre de référence des maladies rares [CHU Cochin] Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris IMRB - PGD/"Pathophysiology of Glomerular Diseases" [Créteil] CHU Gabriel Montpied [Clermont-Ferrand] Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Hôpital Cochin [AP-HP] Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Institut des Maladies Métaboliques et Cardiovasculaires Département de Néphrologie et Transplantation d'organes [CHU Toulouse] Hôpital Henri Mondor Hôpital Cochin [AP-HP] Hospices Civils de Lyon Université Claude Bernard Lyon 1 Lymphocytes B, Autoimmunité et Immunothérapies CHRU Brest - Service de Rhumatologie AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Régional Universitaire de Tours Hôpital Cochin [AP-HP] Université Paris Descartes - Paris 5 IMRB - PGD/"Pathophysiology of Glomerular Diseases" [Créteil] CHU Saint-Antoine [AP-HP] Hôpital Privé de Provence [Aix-en-Provence] Centre Hospitalier Régional Universitaire [Montpellier] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes
• Publié dans Orphanet Journal of Rare Diseases le 27/10/2020

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Résumé : Systemic necrotizing vasculitis comprises a group of diseases resembling polyarteritis nodosa and anti-neutrophil cytoplasmic antibody-associated vasculitis (ANCA): granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. The definitive diagnosis is made in cooperation with a reference center for autoimmune diseases and rare systemic diseases or a competency center. The management goals are: to obtain remission and, in the long term, healing; to reduce the risk of relapses; to limit and reduce the sequelae linked to the disease; to limit the side effects and the sequelae linked to the treatments; to improve or at least maintain the best possible quality of life; and to maintain socio-professional integration and/or allow a rapid return to school and/or professional activity. Information and therapeutic education of the patients and those around them are an integral part of the care. All health professionals and patients should be informed of the existence of patient associations. The treatment of vasculitis is based on variable combinations of glucocorticoids and immunosuppressants, chosen and adapted according to the disease concerned, the severity and/or extent of the disease, and the underlying factors (age, kidney function, etc.). Follow-up clinical and paraclinical examinations must be carried out regularly to clarify the progression of the disease, detect and manage treatment failures and possible relapses early on, and limit sequelae and complications (early then late) related to the disease or treatment. A distinction is made between the induction therapy, lasting approximately 3-6 months and aimed at putting the disease into remission, and the maintenance treatment, lasting 12-48 months, or even longer. The role of the increase or testing positive again for ANCA as a predictor of a relapse, which has long been controversial, now seems to have greater consensus: Anti-myeloperoxidase ANCAs are less often associated with a relapse of vasculitis than anti-PR3 ANCA.

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Fichiers liés : s13023-020-01621-3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Gaultier MarnatBertrand LapergueIgor SibonFlorent GarielRomain BourcierMaéva KyhengJulien LabreucheCyril DargazanliArturo ConsoliRaphaël BlancMichel P. PiotinMikaël MazighiSébastien RichardBenjamin GoryHocine RedjemSimon EscalardJean-Philippe DesillesGabriele CiccioStanislas SmajdaRobert FahedMikael ObadiaCandice SabbenOvide CorabianuThomas de BrouckerDidier SmadjaSonia AlamowitchOlivier IlleEric ManchonPierre-Yves GarciaGuillaume TaylorMalek Ben MaachaFrédéric BourdainJean-Pierre DecroixAdrien WangSerge EvrardMaya TchikviladzeOguzhan CoskunFederico Di MariaGeorges RodeshMorgan LeguenMarie TisserandFernando PicoHaja RakotoharinandrasanaPhilippe TassanRoxanna PollNorbert NighoghossianRoberto RivaOmer EkerFrancis TurjmanLaurent DerexTae-Hee ChoLaura MechtouffAnne Claire LukaszewiczFrédéric PhilippeauSerkan CakmakKarine Blanc-LasserreAnne-Evelyne ValletXavier BarreauJérôme BergePatrice MenegonLudovic LucasStéphane OlindoPauline RenouSharmila SagnierMathilde PoliSabrina DebruxellesFrançois RouanetThomas TourdiasJean-Sebastien LiegeyLili DetrazBenjamin Daumas-DuportPierre-Louis AlexandreMonica RoyCédric LenobleVincent L’allinecJean-Baptiste GirotHubert DesalSerge BracardRené AnxionnatMarc BraunAnne-Laure DerelleRomain TonneletLiang LiaoFrançois ZhuEmmanuelle SchmittSophie PlanelLisa HumbertjeanGioia MioneJean-Christophe LacourMathieu BonnerotNolwenn Riou-ComteVincent CostalatGrégory GascouPierre-Henri LefèvreImad DerrazCarlos RiquelmeCaroline ArquizanNicolas GaillardIsabelle MourandLucas CortiFederico CagnazzoMohammad AnadaniAlejandro SpiottaAli AlawiehDiogo HaussenRaul NogueiraPanagiotis PapanagiotouAdnan SiddiquiFranziska DornChristophe CognardMarc RiboMarios PsychogiosMarc Antoine LabeyrieAlessandra BiondiJonathan Andrew GrossbergAdrien GuenegoJulien DarcourtIsabelle VukasinovicElisa PomeroJason DaviesLeonardo RenieriCorentin HeckerMaria Muchada MuchadaEmmanuel HoudartRaymond TurnerAquilla TurkImran ChaudryJohanna LockauAndreas KastrupDaniel BehmeHussain ShallwaniMaurer Christopher
• Organismes : Département de Neuro-Radiologie [Bordeaux] Hôpital Foch [Suresnes] UFR Sciences de la santé Simone Veil Service de neurologie [Bordeaux] Département de Neuro-Radiologie [Bordeaux] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Fondation Ophtalmologique Adolphe de Rothschild [Paris] Santé Publique : épidémiologie et qualité des soins Centre Hospitalier Régional Universitaire [CHU Lille] Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Santé Publique : épidémiologie et qualité des soins Centre Hospitalier Régional Universitaire [CHU Lille] Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Département de Neuroradiologie[Montpellier] Hôpital Foch [Suresnes] Imagerie Adaptative Diagnostique et Interventionnelle UFR Sciences de la santé Simone Veil Fondation Ophtalmologique Adolphe de Rothschild [Paris] Fondation Ophtalmologique Adolphe de Rothschild [Paris] Fondation Ophtalmologique Adolphe de Rothschild [Paris] Service de neurologie [CHRU Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Imagerie Adaptative Diagnostique et Interventionnelle Imagerie Adaptative Diagnostique et Interventionnelle Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans Stroke le 31/10/2020

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Résumé : Background and Purpose: The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable to that for isolated intracranial occlusion in the anterior circulation. However, the optimal management of acute cervical internal carotid artery lesions is unknown, especially in the setting of carotid dissection, but emergency carotid artery stenting (CAS) is frequently considered. We investigated the safety and efficacy of emergency CAS for carotid dissection in patients with acute stroke with tandem occlusion in current clinical practice. Methods: We retrospectively analyzed a prospectively maintained database composed of 2 merged multicenter international observational real-world registries (Endovascular Treatment in Ischemic Stroke and Thrombectomy in Tandem Lesion). Data from endovascular therapy performed in the treatment of tandem occlusions related to acute cervical carotid dissection between January 2012 and January 2019 at 24 comprehensive stroke centers were analyzed. Results: The study assessed 136 patients with tandem occlusion due to dissection, including 65 (47.8%) treated with emergency CAS and 71 (52.2%) without. The overall rates of favorable outcome (90-day modified Rankin Scale score, 0–2) and successful reperfusion (modified Thrombolysis in Cerebral Infarction, 2b–3) were 58.0% (n=76 [95% CI, 49.6%–66.5%]) and 77.9% (n=106 [95% CI, 71.0%–85.0%]), respectively. In subgroup analyses, the rate of successful reperfusion (89.2% versus 67.6%; adjusted odds ratio, 2.24 [95% CI, 1.33–3.77]) was higher after CAS, whereas the 90-day favorable outcome (54.3% versus 61.4%; adjusted odds ratio, 0.84 [95% CI, 0.58–1.22]), symptomatic intracerebral hemorrhage (sICH; 10.8% versus 5.6%; adjusted odds ratio, 1.59 [95% CI, 0.79–3.17]), and 90-day mortality (8.0% versus 5.8%; adjusted odds ratio, 1.00 [95% CI, 0.48–2.09]) did not differ. In sensitivity analyses of patients with successful intracranial reperfusion, CAS was not associated with an improved clinical outcome. Conclusions: Emergency stenting of the dissected cervical carotid artery during endovascular therapy for tandem occlusions seems safe, whatever the quality of the intracranial reperfusion.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Olivier MalardFranck DuteilleEric DarnisFlorent EspitalierPierre PerrotChristophe FerronLucie PlancheJean-Benoit HardouinPhilippe TessierMartine BellangerMartine BellangerCécile Dert
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital École des Hautes Études en Santé Publique Arènes: politique, santé publique, environnement, médias Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Plastic and Reconstructive Surgery le 02/11/2020

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Résumé : Background: Deep dermal suturing is critical for scar quality outcomes. The authors evaluated a new, fast medical device for dermal suturing, with the hypothesis of noninferiority with regard to clinical scar and cost-effectiveness.Methods: A prospective, patient-blind, randomized, multicenter noninferiority study in 26 French hospitals was conducted. Patients were randomized 1:1 to suturing with conventional thread or a semiautomatic stapler. The Patient Scar Assessment Scale was rated at 3 months for primary endpoint effectiveness. Secondary endpoints were cost-effectiveness of the two suturing methods, prevalence of complications, suturing/operating time, Observer Scar Assessment Scale and Patient Scar Assessment Scale score, scar aesthetic quality 18 months after surgery, and occupational exposure to blood during surgery.Results: Six hundred sixty-four patients were enrolled, 660 were randomized, and 649 constituted the full analysis (stapler arm, n = 324; needle arm, n = 325). Primary endpoint Patient Scar Assessment Scale score in the stapler arm was not inferior to that in the needle arm at 3 months or after 18 months. The mean operating time was 180 minutes in the stapler arm and 179 minutes in the needle arm (p = not significant). The mean suturing time was significantly lower in the stapler arm (p < 0.001). There were seven occupational exposures to blood in the needle arm and one in the stapler arm. The two arms did not differ significantly in terms of complications (p = 0.41). The additional cost of using the device was &OV0556;51.57 for the complete-case population.Conclusion: Wound healing outcome was no worse than with conventional suturing using a semiautomatic stapler and associated with less occupational exposure to blood.Clinical question/level of evidence: Therapeutic, I.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Antonio MolinaroPierre Bel LassenMarcus HenricssonHao WuSolia AdriouchEugeni BeldaRima ChakarounTrine NielsenPer-Olof BerghChristine RouaultSébastien AndréFlorian MarquetFabrizio AndreelliJoe‐elie SalemKaren AssmannJean-Philippe BastardSofia ForslundEmmanuelle Le ChatelierGwen FalonyNicolas PonsEdi PriftiBenoit QuinquisHugo RoumeSara Vieira-SilvaTue Haldor HansenHelle Krogh PedersenChristian LewinterNadja SøndertoftLars KøberHenrik VestergaardTorben HansenJean-Daniel ZuckerPilar GalanMarc-Emmanuel DumasJeroen RaesJean-Michel OppertIvica LetunicJens NielsenPeer BorkStanislav Dusko EhrlichMichael StumvollOluf PedersenJudith Aron-WisnewskyKarine ClémentFredrik Bäckhed
• Organismes : Göteborgs Universitet = University of Gothenburg Sahlgrenska University Hospital [Gothenburg] Nutrition et obésités: approches systémiques (UMR-S 1269) Centre de Recherche en Nutrition Humaine d'Ile-de-France Göteborgs Universitet = University of Gothenburg Göteborgs Universitet = University of Gothenburg Nutrition et obésités: approches systémiques (UMR-S 1269) Nutrition et obésités: approches systémiques (UMR-S 1269) Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Leipzig University / Universität Leipzig University of Copenhagen = Københavns Universitet Göteborgs Universitet = University of Gothenburg Nutrition et obésités: approches systémiques (UMR-S 1269) Nutrition et obésités: approches systémiques (UMR-S 1269) Nutrition et obésités: approches systémiques (UMR-S 1269) Nutrition et obésités: approches systémiques (UMR-S 1269) Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Nutrition et obésités: approches systémiques (UMR-S 1269) CHU Tenon [AP-HP] Charité - UniversitätsMedizin = Berlin University Medicine Max Delbrück Center for Molecular Medicine [Berlin] MICrobiologie de l'ALImentation au Service de la Santé Catholic University of Leuven = Katholieke Universiteit Leuven VIB-KU Leuven Center for Microbiology MICrobiologie de l'ALImentation au Service de la Santé Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé Catholic University of Leuven = Katholieke Universiteit Leuven VIB-KU Leuven Center for Microbiology University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet University of Copenhagen = Københavns Universitet Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Imperial College London National Heart and Lung Institute [London] MICrobiologie de l'ALImentation au Service de la Santé Catholic University of Leuven = Katholieke Universiteit Leuven Centre de Recherche en Nutrition Humaine d'Ile-de-France Biobyte Solutions GMBH Chalmers University of Technology [Gothenburg, Sweden] European Molecular Biology Laboratory [Heidelberg] Universität Heidelberg [Heidelberg] = Heidelberg University MICrobiologie de l'ALImentation au Service de la Santé Leipzig University / Universität Leipzig University of Copenhagen = Københavns Universitet Nutrition et obésités: approches systémiques (UMR-S 1269) Centre de Recherche en Nutrition Humaine d'Ile-de-France Nutrition et obésités: approches systémiques (UMR-S 1269) Centre de Recherche en Nutrition Humaine d'Ile-de-France Göteborgs Universitet = University of Gothenburg Sahlgrenska University Hospital [Gothenburg]
• Publié dans Nature Communications le 23/10/2020

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Résumé : No abstract available

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Fichiers liés : s41467-020-20412-9.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Philippe BarralMartine JolyPierre NouvelMatthieu Thivet
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (UAR 3124) Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Archéologie, Terre, Histoire, Sociétés [Dijon] Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (UAR 3124)
• Publié dans L'Archéologue le 23/03/2018

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Philippe CouvertPhilippe GiralPierre -Yves BoelleValérie CarreauSophie BéliardJean -Marc LacortePhilippe CluzelFrancois PaillardRené ValéroAnnelies RotthierÉric BruckertAlain Carrié
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Internal Medicine Journal le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Jean-Pierre BakhoumNdeye DiopEl Hadji T. BodianOlivier MbayePape. DiawLamine CisseMame Gaye-SeyeDiene ThiareAtanasse ColyBernard Le JeunePhilippe Giamarchi
• Organismes : Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme Université Alioune Diop de Bambey Laboratoire d'Optique et de Magnétisme Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme Université Cheikh Anta Diop de Dakar [Sénégal] Université Alioune Diop de Bambey Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire Géomatériaux et Environnement Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme Laboratoire d'Optique et de Magnétisme
• Publié dans Environmental Science and Pollution Research le 22/10/2020

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Résumé : This paper describes prototypes of an on-site early warning water quality monitoring system (EWWQMS) for pesticide quantification in natural waters by fluorescence and absorbance. As many pesticides are not naturally fluorescent, this EWWQMS uses UV irradiation to transform these compounds into highly fluorescent photoproducts and obtain sufficient sensitivity. To obtain a better specificity, the system uses four UV LEDs at different wavelengths to excite the fluorescent photoproducts. For pesticides that are not sensitive to photoconversion, the EWWQMS prototypes also use UV absorption for their quantification, thus offering a wider application range. A first system uses a diode array spectrometer for detection. A second system uses a higher resolution spectrometer and an intensified CCD camera detection to increase sensitivity. Analytical applications were conducted for the determination of fipronil, acetamipride, cyprodinil, trifluraline and pendimethaline in water using both the EWWQMS prototypes. The analytical performances of these new systems are good compared with other photo-induced fluorescence methods already published. Limits of detection without pre-concentration are in the range of 0.2 to 3 ng mL−1 and the recovery values range from 95 to 108%. These results show that the EWWQMS prototypes can be used as an alert system to protect industrial plants from pesticide contaminations that exceed the capabilities of their cleaning processes.

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• Type de publi. :
• Date de publi. : 01/12/2020
• Auteurs : Laëtitia LemrabetCécile LasserreMarie-Pierre DoinAnne ReplumazMarianne MétoisPhilippe-Hervé LeloupJ. SunM. L. Chevalier
• Organismes : Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Institut des Sciences de la Terre Institut des Sciences de la Terre Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement State Key Laboratory of Earthquake Dynamics Chinese Academy of Geological Sciences [Beijing]

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Résumé : The global and systematic coverage of Sentinel-1 radar images enables to characterize, by radar interferometry, surface deformations at the scale of large active fault systems. This represents considerable progress in fault monitoring and opens new perspectives in seismic hazard assessment. Our study focuses on the Yushu - Ganzi - Xian Shui He active fault system (YGX), one of the most seismically active left-lateral fault system on the eastern part of the Tibetan plateau, which contributes to accommodate the collision between the Indian and the Eurasian plates. We analyze in particular the present-day behavior of the Ganzi segment of the YGX fault system, which may represent a 350 km-long seismic gap, unbroken for the past ~120 years. To measure the interseismic deformation across the YGX fault system, we perform a time series analysis of 4 years of Sentinel-1 InSAR data, acquired along ascending and descending orbits, using the New Small Baseline Subset processing chain including the latest adaptations (Doin et al., 2011, Grandin, 2015). Our results are presented as mean velocity maps across the fault system and highlight creep process along different sections of the YGX fault system. We present here a spatial and temporal characterization of this creep, analyzing series of mean velocity profiles, derived from Sentinel-1 InSAR data. We also propose a preliminary block model analysis constrained from both InSAR and GPS interseismic surface velocities to discuss strain localization and rates at a regional scale in the light of the tectonic and geological evolution of this area.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Florence BoissierValérie SeegersAmélie SeguinStephane LegrielAlain CariouSamir JaberJean-Yves LefrantThomas RimmeléAnne RenaultIsabelle VinatierArmelle MathonnetDanielle ReuterOlivier GuissetChristophe CraccoJacques Durand-GasselinBéatrice EonMarina ThirionJean-Philippe RigaudBénédicte Philippon-JouveLaurent ArgaudRenaud ChouquerLaurent PapazianCéline DedrieHugues GeorgesEddy LebasNathalie RolinPierre-Edouard BollaertLucien LecuyerGerald ViquesnelMarc LeoneLudivine Chalumeau-LemoineMaïté Garrouste-OrgeasÉlie AzoulayNancy Kentish-Barnes
• Organismes : Service de réanimation médicale Institut de Cancérologie de l'Ouest [Angers/Nantes] Service de réanimation médicale [CHU Caen] Unité de Soins Intensifs [CH Versailles] COIITSS Study Investigators Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires Service d'anesthésie-réanimation [Centre Hospitalier Lyon Sud - HCL] Centre de recherche en éducation de Nantes Service de Réanimation CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Bordeaux Unité de soins Continus Centre Hospitalier de Toulon-La Seyne Assistance Publique - Hôpitaux de Marseille Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Hôpital Edouard Herriot [CHU - HCL] Hôpital Nord [CHU - APHM] Service de Réanimation polyvalente et des Maladies infectieuses Faculté de Médecine [Nancy] Service de biostatistiques et information médicale [Saint-Louis] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Microbes Evolution Phylogénie et Infections Département d'anesthésie, réanimation et pathologie infectieuse Epidémiologie pronostique des cancers et affections graves Hopital Saint-Louis [AP-HP] Hôpital Saint-Louis
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: As an increasing number of deaths occur in the intensive care unit (ICU), studies have sought to describe, understand, and improve end-of-life care in this setting. Most of these studies are centered on the patient's and/or the relatives' experience. Our study aimed to develop an instrument designed to assess the experience of physicians and nurses of patients who died in the ICU, using a mixed methodology and validated in a prospective multicenter study. Methods: Physicians and nurses of patients who died in 41 ICUs completed the job strain and the CAESAR questionnaire within 24 h after the death. The psychometric validation was conducted using two datasets: a learning and a reliability cohort. Results: Among the 475 patients included in the main cohort, 398 nurse and 417 physician scores were analyzed. The global score was high for both nurses [62/75 (59; 66)] and physicians [64/75 (61; 68)]. Factors associated with higher CAESAR-Nurse scores were absence of conflict with physicians, pain control handled with physicians, death disclosed to the family at the bedside, and invasive care not performed. As assessed by the job strain instrument, low decision control was associated with lower CAESAR score (61 (58; 65) versus 63 (60; 67), p = 0.002). Factors associated with higher CAESAR-Physician scores were room dedicated to family information, information delivered together by nurse and physician, families systematically informed of the EOL decision, involvement of the nurse during implementation of the EOL decision, and open visitation. They were also higher when a decision to withdraw or withhold treatment was made, no cardiopulmonary resuscitation was performed, and the death was disclosed to the family at the bedside. Conclusion: We described and validated a new instrument for assessing the experience of physicians and nurses involved in EOL in the ICU. This study shows important areas for improving practices.

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Fichiers liés : 2020 Boissier et al., Assessing.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Sophie SusenCharles Ambroise TacquardAlexandre GodonAlexandre MansourDelphine GarriguePhilippe NguyenAnne GodierSophie TestaJerrold LevyPierre AlbaladejoYves GruelN. BlaisF. BonhommeAnnie Borel-DerlonAriel CohenJ.-P. ColletE. de MaistreP. FontanaB. IckxSilvy LaporteD. LasneJ. LlauG. Le GalT. LecompteS. LessireD. LongroisS. Madi-JebaraM. MazighiPatrick MismettiP. MorangeS. MotteF. MullierN. NathanGilles PernodN. RosencherS. RoulletP. RoyS. SchlumbergerP. SiéA. SteibA. VincentelliP. ZuffereyE. BoissierB. DumontC. JamesVirginie Siguret
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Service d'Anesthésie-Réanimation [Strasbourg] Pôle anesthésie-réanimation Service d'Anesthésie Réanimation [Rennes] Service des Maladies du Sang [CHU Lille] Hôpital universitaire Robert Debré [Reims] Hémostase et Remodelage Vasculaire Post-Ischémie Service de Pneumologie et Soins Intensifs [CHU HEGHP] Istituti Ospitalieri di Cremona Duke University [Durham] Pôle anesthésie-réanimation Service d'hématologie [Tours] Centre Hospitalier Universitaire University of Arizona Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Dijon Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Service d’Hématologie Biologique [CHU Lariboisière] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associated with coagulation changes, mainly characterized by an increase in D-dimer and fibrinogen levels, with a higher risk of thrombosis, particularly pulmonary embolism. The impact of obesity in severe COVID-19 has also been highlighted. In this context, standard doses of low molecular weight heparin (LMWH) may be inadequate in ICU patients, with obesity, major inflammation, and hypercoagulability. We therefore urgently developed proposals on the prevention of thromboembolism and monitoring of hemostasis in hospitalized patients with COVID-19. Four levels of thromboembolic risk were defined according to the severity of COVID-19 reflected by oxygen requirement and treatment, the body mass index, and other risk factors. Monitoring of hemostasis (including fibrinogen and D-dimer levels) every 48 h is proposed. Standard doses of LMWH (e.g., enoxaparin 4000 IU/24 h SC) are proposed in case of intermediate thrombotic risk (BMI < 30 kg/m 2 , no other risk factors and no ARDS). In all obese patients (high thrombotic risk), adjusted prophylaxis with intermediate doses of LMWH (e.g., enoxaparin 4000 IU/12 h SC or 6000 IU/12 h SC if weight > 120 kg), or unfractionated heparin (UFH) if renal insufficiency (200 IU/kg/24 h, IV), is proposed. The thrombotic risk was defined as very high in obese patients with ARDS and added risk factors for thromboembolism, and also in case of extracorporeal membrane oxygenation (ECMO), unexplained catheter thrombosis, dialysis filter thrombosis, or marked inflammatory syndrome and/or hypercoagulability (e.g., fibrinogen > 8 g/l and/or D-dimers > 3 μg/ml). In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed. In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed.

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Fichiers liés : s13054-020-03000-7.pdf

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