Philippe JEAN-PIERRE

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• Type de publi. :
• Date de publi. : 01/12/2020
• Auteurs : Laëtitia LemrabetCécile LasserreMarie-Pierre DoinAnne ReplumazMarianne MétoisPhilippe-Hervé LeloupJ. SunM. L. Chevalier
• Organismes : Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Institut des Sciences de la Terre Institut des Sciences de la Terre Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement State Key Laboratory of Earthquake Dynamics Chinese Academy of Geological Sciences [Beijing]

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Résumé : The global and systematic coverage of Sentinel-1 radar images enables to characterize, by radar interferometry, surface deformations at the scale of large active fault systems. This represents considerable progress in fault monitoring and opens new perspectives in seismic hazard assessment. Our study focuses on the Yushu - Ganzi - Xian Shui He active fault system (YGX), one of the most seismically active left-lateral fault system on the eastern part of the Tibetan plateau, which contributes to accommodate the collision between the Indian and the Eurasian plates. We analyze in particular the present-day behavior of the Ganzi segment of the YGX fault system, which may represent a 350 km-long seismic gap, unbroken for the past ~120 years. To measure the interseismic deformation across the YGX fault system, we perform a time series analysis of 4 years of Sentinel-1 InSAR data, acquired along ascending and descending orbits, using the New Small Baseline Subset processing chain including the latest adaptations (Doin et al., 2011, Grandin, 2015). Our results are presented as mean velocity maps across the fault system and highlight creep process along different sections of the YGX fault system. We present here a spatial and temporal characterization of this creep, analyzing series of mean velocity profiles, derived from Sentinel-1 InSAR data. We also propose a preliminary block model analysis constrained from both InSAR and GPS interseismic surface velocities to discuss strain localization and rates at a regional scale in the light of the tectonic and geological evolution of this area.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Florence BoissierValérie SeegersAmélie SeguinStephane LegrielAlain CariouSamir JaberJean-Yves LefrantThomas RimmeléAnne RenaultIsabelle VinatierArmelle MathonnetDanielle ReuterOlivier GuissetChristophe CraccoJacques Durand-GasselinBéatrice EonMarina ThirionJean-Philippe RigaudBénédicte Philippon-JouveLaurent ArgaudRenaud ChouquerLaurent PapazianCéline DedrieHugues GeorgesEddy LebasNathalie RolinPierre-Edouard BollaertLucien LecuyerGerald ViquesnelMarc LeoneLudivine Chalumeau-LemoineMaïté Garrouste-OrgeasÉlie AzoulayNancy Kentish-Barnes
• Organismes : Service de réanimation médicale Institut de Cancérologie de l'Ouest [Angers/Nantes] Service de réanimation médicale [CHU Caen] Unité de Soins Intensifs [CH Versailles] COIITSS Study Investigators Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires Service d'anesthésie-réanimation [Centre Hospitalier Lyon Sud - HCL] Centre de recherche en éducation de Nantes Service de Réanimation CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Bordeaux Unité de soins Continus Centre Hospitalier de Toulon-La Seyne Assistance Publique - Hôpitaux de Marseille Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Hôpital Edouard Herriot [CHU - HCL] Hôpital Nord [CHU - APHM] Service de Réanimation polyvalente et des Maladies infectieuses Faculté de Médecine [Nancy] Service de biostatistiques et information médicale [Saint-Louis] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Microbes Evolution Phylogénie et Infections Département d'anesthésie, réanimation et pathologie infectieuse Epidémiologie pronostique des cancers et affections graves Hopital Saint-Louis [AP-HP] Hôpital Saint-Louis
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: As an increasing number of deaths occur in the intensive care unit (ICU), studies have sought to describe, understand, and improve end-of-life care in this setting. Most of these studies are centered on the patient's and/or the relatives' experience. Our study aimed to develop an instrument designed to assess the experience of physicians and nurses of patients who died in the ICU, using a mixed methodology and validated in a prospective multicenter study. Methods: Physicians and nurses of patients who died in 41 ICUs completed the job strain and the CAESAR questionnaire within 24 h after the death. The psychometric validation was conducted using two datasets: a learning and a reliability cohort. Results: Among the 475 patients included in the main cohort, 398 nurse and 417 physician scores were analyzed. The global score was high for both nurses [62/75 (59; 66)] and physicians [64/75 (61; 68)]. Factors associated with higher CAESAR-Nurse scores were absence of conflict with physicians, pain control handled with physicians, death disclosed to the family at the bedside, and invasive care not performed. As assessed by the job strain instrument, low decision control was associated with lower CAESAR score (61 (58; 65) versus 63 (60; 67), p = 0.002). Factors associated with higher CAESAR-Physician scores were room dedicated to family information, information delivered together by nurse and physician, families systematically informed of the EOL decision, involvement of the nurse during implementation of the EOL decision, and open visitation. They were also higher when a decision to withdraw or withhold treatment was made, no cardiopulmonary resuscitation was performed, and the death was disclosed to the family at the bedside. Conclusion: We described and validated a new instrument for assessing the experience of physicians and nurses involved in EOL in the ICU. This study shows important areas for improving practices.

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Fichiers liés : 2020 Boissier et al., Assessing.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Sophie SusenCharles Ambroise TacquardAlexandre GodonAlexandre MansourDelphine GarriguePhilippe NguyenAnne GodierSophie TestaJerrold LevyPierre AlbaladejoYves GruelN. BlaisF. BonhommeAnnie Borel-DerlonAriel CohenJ.-P. ColletE. de MaistreP. FontanaB. IckxSilvy LaporteD. LasneJ. LlauG. Le GalT. LecompteS. LessireD. LongroisS. Madi-JebaraM. MazighiPatrick MismettiP. MorangeS. MotteF. MullierN. NathanGilles PernodN. RosencherS. RoulletP. RoyS. SchlumbergerP. SiéA. SteibA. VincentelliP. ZuffereyE. BoissierB. DumontC. JamesVirginie Siguret
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Service d'Anesthésie-Réanimation [Strasbourg] Pôle anesthésie-réanimation Service d'Anesthésie Réanimation [Rennes] Service des Maladies du Sang [CHU Lille] Hôpital universitaire Robert Debré [Reims] Hémostase et Remodelage Vasculaire Post-Ischémie Service de Pneumologie et Soins Intensifs [CHU HEGHP] Istituti Ospitalieri di Cremona Duke University [Durham] Pôle anesthésie-réanimation Service d'hématologie [Tours] Centre Hospitalier Universitaire University of Arizona Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Dijon Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Service d’Hématologie Biologique [CHU Lariboisière] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associated with coagulation changes, mainly characterized by an increase in D-dimer and fibrinogen levels, with a higher risk of thrombosis, particularly pulmonary embolism. The impact of obesity in severe COVID-19 has also been highlighted. In this context, standard doses of low molecular weight heparin (LMWH) may be inadequate in ICU patients, with obesity, major inflammation, and hypercoagulability. We therefore urgently developed proposals on the prevention of thromboembolism and monitoring of hemostasis in hospitalized patients with COVID-19. Four levels of thromboembolic risk were defined according to the severity of COVID-19 reflected by oxygen requirement and treatment, the body mass index, and other risk factors. Monitoring of hemostasis (including fibrinogen and D-dimer levels) every 48 h is proposed. Standard doses of LMWH (e.g., enoxaparin 4000 IU/24 h SC) are proposed in case of intermediate thrombotic risk (BMI < 30 kg/m 2 , no other risk factors and no ARDS). In all obese patients (high thrombotic risk), adjusted prophylaxis with intermediate doses of LMWH (e.g., enoxaparin 4000 IU/12 h SC or 6000 IU/12 h SC if weight > 120 kg), or unfractionated heparin (UFH) if renal insufficiency (200 IU/kg/24 h, IV), is proposed. The thrombotic risk was defined as very high in obese patients with ARDS and added risk factors for thromboembolism, and also in case of extracorporeal membrane oxygenation (ECMO), unexplained catheter thrombosis, dialysis filter thrombosis, or marked inflammatory syndrome and/or hypercoagulability (e.g., fibrinogen > 8 g/l and/or D-dimers > 3 μg/ml). In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed. In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed.

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Fichiers liés : s13054-020-03000-7.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Soumaya JadouiOphélie Le ChapelainVéronique OllivierAli Mostefa-KaraLucas Di MeglioSebastien DupontAngèle GrosMialitiana Solo NomenjanaharyJean-Philippe DesillesMikaël MazighiBernhard NieswandtStéphane LoyauMartine Jandrot- PerrusPierre H. ManginBenoit Ho-Tin-Noé
• Organismes : Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle CHU Rothschild [AP-HP] Laboratoire de Recherche Vasculaire Translationnelle CHU Rothschild [AP-HP] University Hospital of Würzburg Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Biologie et Pharmacologie des Plaquettes sanguines : hémostase, thrombose, transfusion Laboratoire de Recherche Vasculaire Translationnelle
• Publié dans Haematologica le 30/10/2020

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Résumé : Not available

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Fichiers liés : Letter Jadoui Final Revision.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 30/11/2020
• Auteurs : Johan QuilbéLéo LamyLaurent BrottierPhilippe LeleuxJoel FardouxRonan RivallanThomas BenichouRémi GuyonnetManuel BecanaIrene VillarOlivier GarsmeurBárbara HufnagelAmandine DelteilDjamel GullyClémence ChaintreuilMarjorie PerventFabienne CartieauxMickaël BourgeNicolas ValentinGuillaume MartinLoïc FontaineGaetan DrocAlexis DereeperAndrew D. FarmerCyril LibourelNico NouwenFrederic GressentPierre MournetAngélique D’ HontEric GiraudChristophe KloppJean-François Arrighi
• Organismes : Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Plateforme Bio-Informatique - Génotoul Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Plateforme Bio-Informatique - Génotoul Laboratoire des symbioses tropicales et méditerranéennes Institut de Recherche pour le Développement Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Département Systèmes Biologiques Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Biochimie et Physiologie Moléculaire des Plantes Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Institut de Biologie Intégrative de la Cellule Cytométrie Institut de Biologie Intégrative de la Cellule Cytométrie Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Biologie et Génétique des Interactions Plante-Parasite Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques National center for genome resources Laboratoire de Recherche en Sciences Végétales Laboratoire des symbioses tropicales et méditerranéennes Laboratoire des symbioses tropicales et méditerranéennes Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Laboratoire des symbioses tropicales et méditerranéennes Plateforme Bio-Informatique - Génotoul Laboratoire des symbioses tropicales et méditerranéennes

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Résumé : Among legumes (Fabaceae) capable of nitrogen-fixing nodulation, several Aeschynomene spp. use a unique symbiotic process that is independent of Nod factors and infection threads. They are also distinctive in developing root and stem nodules with photosynthetic bradyrhizobia. Despite the significance of these symbiotic features, their understanding remains limited. To overcome such limitations, we conducted genetic studies of nodulation in Aeschynomene evenia , supported by the development of a genome sequence for A. evenia and transcriptomic resources for 10 additional Aeschynomene spp. Comparative analysis of symbiotic genes substantiated singular mechanisms in the early and late nodulation steps. A forward genetic screen also showed that AeCRK , coding a novel receptor-like kinase, and the symbiotic signaling genes AePOLLUX, AeCCamK, AeCYCLOPS, AeNSP2 and AeNIN , are required to trigger both root and stem nodulation. This work demonstrates the utility of the A. evenia model and provides a cornerstone to unravel new mechanisms underlying the rhizobium-legume symbiosis.

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Fichiers liés : QuilbeJ.-et al-bioRixv-2020.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 27/11/2020
• Auteurs : Mauricio Lopez-ObandoAmbre GuilloryFrançois-Didier BoyerDavid CornuBeate HoffmannPhilippe Le BrisJean-Bernard PouvreauP DelavaultCatherine RameauAlexandre de Saint GermainSandrine Bonhomme
• Organismes : Institut de Chimie des Substances Naturelles Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : In flowering plants, the α/β hydrolase DWARF14 (D14) perceives strigolactone (SL) hormones and interacts with the F-box protein MORE AXILLARY GROWTH2 (MAX2) to regulate developmental processes. The key SL biosynthetic enzyme, CAROTENOID CLEAVAGE DEOXYGENASE8 (CCD8), is present in the moss Physcomitrium (Physcomitrella) patens , and PpCCD8-derived compounds regulate plant extension. However, perception of these still unknown compounds does not require the PpMAX2 homolog. Putative candidate receptors are among the 13 PpKAI2LIKE-A to -L genes, homologous to the ancestral D14 paralog KARRIKIN INSENSITIVE2 ( KAI2 ). In Arabidopsis, AtKAI2 is the receptor for karrikins and a still elusive endogenous KAI2-Ligand (KL). Based on germination assays using seeds of the parasitic plant Phelipanche ramosa , we propose that PpCCD8-derived compounds are non-canonical SLs. We show that all tested PpKAI2L proteins can bind and cleave SL analogs, some with similar affinities to AtKAI2. The PpKAI2L-H protein shows a strong hydrolytic activity not found for other PpKAI2L. Moss mutants for all PpKAI2L gene subclades were obtained and tested for their response to SL analogs. We show that PpKAI2L-A to -E genes encode redundant proteins that are not involved in PpCCD8-derived compound perception, but rather act in a PpMAX2-dependant pathway. In contrast, mutations in PpKAI2L-G , and - J genes abolish the response to the SL analog (+)-GR24, suggesting that both these encoded proteins are receptors for PpCCD8-derived molecules.

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Fichiers liés : 2020.11.24.395954v1.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/11/2020
• Auteurs : Hanspeter NaegeliJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiAntonio Fernandez Dumont
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : This statement supplements and updates the GMO Panel guidance document on allergenicity of genetically modified (GM) plants published in 2017. In that guidance document, the GMO Panel considered that additional investigations on in vitro protein digestibility were needed before providing any additional recommendations in the form of guidance to applicants. Thus, an interim phase was proposed to assess the utility of an enhanced in vitro digestion test, as compared to the classical pepsin resistance test. Historically, resistance to degradation by pepsin using the classical pepsin resistance test has been considered as additional information, in a weight-of-evidence approach, for the assessment of allergenicity and toxicity of newly expressed proteins in GM plants. However, more recent evidence does not support this test as a good predictor of allergenic potential for hazard. Furthermore, there is a need for more reliable systems to predict the fate of the proteins in the gastrointestinal tract and how they interact with the relevant human cells. Nevertheless, the classical pepsin resistance test can still provide some information on the physicochemical properties of novel proteins relating to their stability under acidic conditions. But other methods can be used to obtain data on protein's structural and/or functional integrity. It is acknowledged that the classical pepsin resistance test is embedded into international guidelines, e.g. Codex Alimentarius and Regulation (EU) No 503/2013. For future development, a deeper understanding of protein digestion in the gastrointestinal tract could enable the framing of more robust strategies for the safety assessment of proteins. Given the high complexity of the digestion and absorption process of dietary proteins, it is needed to clarify and identify the aspects that could be relevant to assess potential risks of allergenicity and toxicity of proteins. To this end, a series of research questions to be addressed are also formulated in this statement.

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Fichiers liés : j.efsa.2021.6350.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/11/2020
• Auteurs : Hanspeter NaegeliJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiFernando ÁlvarezMichele ArdizzoneGiacomo de SanctisYann DevosAntonio FernandezAndrea GennaroJose Ángel Gómez RuizAnna LanzoniFranco Maria NeriNikoletta PapadopoulouKonstantinos ParaskevopoulosTommaso Raffaello
• Organismes : Institute of Pharmacology and Toxicology [Zurich] Earlham Institute [Norwich] Department of Dermatology Division of Immunology, Allergy and Infectious Diseases Medical University of Vienna = Medizinische Universität Wien Centre for Ecology and Hydrology [Bangor] Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Estonian University of Life Sciences Centre for Water Research Instituto de Fisica "Gleb Wataghin" GMO Unit, European Food Safety Authority European Food Safety Authority Department of Mathematical Sciences [Bath]
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Maize 1507 9 MIR162 9 MON810 9 NK603 (four-event stack maize) was produced by conventional crossing to combine four single events: 1507, MIR162, MON810 and NK603. The GMO Panel previously assessed the four single events and six of the subcombinations and did not identify safety concerns. No new data on the single events or the six subcombinations that could lead to modification of the original conclusions on their safety were identified. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in the four-event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the four-event stack maize, as described in this application, is as safe as its non-GM comparator and the non-GM reference varieties tested. In the case of accidental release of viable seeds of the four-event stack maize into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in the four maize subcombinations not previously assessed and concludes that these are expected to be as safe as the single events, the previously assessed subcombinations and the four-event stack maize. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of the four-event stack maize. Post-market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the four-event stack maize and its subcombinations are as safe as the non-GM comparator and the tested non-GM reference varieties with respect to potential effects on human and animal health and the environment.

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Fichiers liés : EFS2-19-e06348.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/11/2020
• Auteurs : . GMO EFSA Panel on Genetically Modified OrganismsHanspeter NaegeliJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiFernando ÁlvarezMichele ArdizzoneTommaso Raffaello
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Following the submission of application EFSA-GMO-RX-016 under Regulation (EC) No 1829/2003 from Syngenta the Panel on Genetically Modified Organisms of the European Food Safety Authority was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the insect-resistant and herbicide-tolerant genetically modified maize Bt11, for food and feed uses, excluding cultivation within the European Union. The data received in the context of this renewal application contained post-market environmental monitoring reports, a systematic search and evaluation of literature, updated bioinformatic analyses, and additional documents or studies performed by or on behalf of the applicant. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. Under the assumption that the DNA sequences of the event in maize Bt11 considered for renewal is identical to the sequence of the originally assessed events, the GMO Panel concludes that there is no evidence in renewal application EFSA-GMO-RX-016 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on maize Bt11.

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Fichiers liés : EFS2-19-e06347.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/11/2020
• Auteurs : . GMO EFSA Panel on Genetically Modified OrganismsHanspeter NaegeliJean–louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiFernando ÁlvarezMichele ArdizzoneGiacomo de SanctisAntonio FernandezAndrea GennaroJose Ángel Gómez RuizDafni Maria KagkliAnna LanzoniFranco Maria NeriNikoletta PapadopoulouKonstantinos ParaskevopoulosTommaso Raffaello
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Maize MON 87427 9 MON 87460 9 MON 89034 9 1507 9 MON 87411 9 59122 (six-event stack maize) was produced by conventional crossing to combine six single events: MON 87427, MON 87460, MON 89034, 1507, MON 87411 and 59122. The GMO Panel previously assessed the six single maize events and 17 of the subcombinations and did not identify safety concerns. No new data on the single maize events or the 17 subcombinations were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins and dsRNA in the six-event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the six-event stack maize, as described in this application, is as safe as its non-GM comparator and the selected non-GM reference varieties. In the case of accidental release of viable grains of the six-event stack maize into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in the 39 maize subcombinations not previously assessed and concludes that these are expected to be as safe as the single events, the previously assessed subcombinations and the six-event stack maize. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of the six-event stack maize. Post-market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the six-event stack maize and its subcombinations are as safe as the non-GM comparator and the selected non-GM reference varieties with respect to potential effects on human and animal health and the environment.

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Fichiers liés : EFS2-19-e06351.pdf

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