Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/11/2020
• Auteurs : Laurence BoudetJean-Philippe PoliLouis-Pierre BergeMichel Rodriguez
• Organismes : Intelligence Artificielle et Apprentissage Automatique (CEA, LIST) Intelligence Artificielle et Apprentissage Automatique (CEA, LIST) CEA Tech Occitanie CGX SYSTEM, Castres, France

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Résumé : Decision support systems coupled with a Geographic Information System (GIS) are useful for assessing spatialized risks, which can be either natural, industrial or even anthropic. However, when the knowledge is not sufficiently precise or when the processes are complex, the methods of analysis of the GIS are not always sufficient. In this article, we propose to couple a GIS with a Fuzzy Expert System capable of evaluating fuzzy spatial rules, that is to say, fuzzy rules integrating spatial relations or properties. These are based on fuzzy mathematical morphology and model high-level metric or topological relationships such as “being close to”, “being in the direction of” or “being adjacent to”. The proposed approach has been applied to the identification of risky issues in the case of wildfires. We detail the expert knowledge modeled and show the results obtained in a graphic interface dedicated to the intervention of firefighters.

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Fichiers liés : article_LaurenceBoudet_IEEE2020.pdf

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Source

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/11/2020
• Auteurs : Déborah HarletGuilhem Amin DouilletJean-François GhiennePhilippe RazinPierre DietrichChloé BouscaryFritz Schlunegger
• Organismes : Universität Bern = University of Bern = Université de Berne Institut de physique du globe de Strasbourg Institut Polytechnique de Bordeaux Géosciences Rennes Université de Lausanne = University of Lausanne Universität Bern = University of Bern = Université de Berne

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 07/11/2020
• Auteurs : Andrea Rodriguez-MartinezBin ZhouMarisa SophieaJames BenthamChristopher PaciorekMaria Lc IurilliRodrigo Carrillo-LarcoMariachiara Di CesareCristina TaddeiHonor BixbyGretchen StevensLeanne RileyMelanie CowanStefan SavinEdward GreggRobert BlackLeandra Abarca-GómezZiad AbdeenShynar AbdrakhmanovaSuhaila Abdul GhaffarHanan Abdul RahimNiveen Abu-RmeilehJamila Abubakar GarbaBenjamin Acosta-CazaresRobert AdamsWichai AekplakornKaosar AfsanaShoaib AfzalImelda AgdeppaJavad Aghazadeh-AttariCarlos Aguilar-SalinasCharles AgyemangMohamad Hasnan AhmadNoor Ani AhmadAli AhmadiNaser AhmadiSoheir AhmedWolfgang AhrensGulmira AitmurzaevaKamel AjlouniHazzaa Al-HazzaaAmani Rashed Al-OthmanRajaa Al-RaddadiMonira AlaroujFadia AlbuhairanShahla AldhukairMohamed AliAbdullah AlkandariAla'A AlkerwiKristine AllinMar Alvarez-PedrerolEman AlyDeepak AmarapurkarParisa AmiriNorbert AmougouPhillippe AmouyelLars Bo AndersenSigmund AnderssenLars ÄngquistRanjit Mohan AnjanaAlireza Ansari-MoghaddamHajer 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TheobaldXenophon TheodoridisLutgarde ThijsNihal ThomasBetina ThuesenLubica TicháErik TimmermansAnne TjonnelandHanna TolonenJanne TolstrupMurat TopbasRoman Topór-MadryLiv Elin TorheimMaría José TormoMichael TornaritisMaties TorrentLaura Torres-ColladoStefania ToselliPierre TraissacThi Tuyet-Hanh TranDimitrios TrichopoulosAntonia TrichopoulouOanh Th TrinhAtul TrivediLechaba TshepoMaria TsiggaShoichiro TsuganeAzaliia TuliakovaMarshall Tulloch-ReidFikru TulluTomi-Pekka TuomainenJaakko TuomilehtoMaria TurleyPer TyneliusThemistoklis TzotzasChristophe TzourioPeter UedaEunice UgelFlora Am UkoliHanno UlmerBelgin UnalZhamyila UsupovaHannu Mt UusitaloNalan UysalJustina VaitkeviciuteGonzalo ValdiviaSusana ValeDamaskini ValviRob van DamJohan van Der HeydenYvonne van Der SchouwKoen van HerckHoang van MinhIrene Gm van ValkengoedDirk VanderschuerenDiego VanuzzoAnette VarboGregorio Varela-MoreirasPatricia Varona-PérezSenthil VasanTomas VegaToomas VeidebaumGustavo Velasquez-MelendezBiruta VelikaGiovanni VeronesiWm Monique VerschurenCesar VictoraGiovanni ViegiLucie VietSalvador VillalpandoPaolo VineisJesus VioqueJyrki VirtanenMarjolein VisserSophie Visvikis-SiestBharathi ViswanathanMihaela VladulescuTiina VlasoffDorja VocanecHenry VölzkeAri VoutilainenSari VoutilainenMartine VrijheidTanja Gm VrijkotteAlisha WadeAline WagnerThomas WaldhörJanette WaltonElvis Oa WambiyaWan Mohamad Wan BebakarWan Nazaimoon Wan MohamudRildo de Souza Wanderley JúniorMing-Dong WangNingli WangQian WangXiangjun WangYa Xing WangYing-Wei WangS Goya WannametheeNicholas WarehamAdelheid WeberNiels WedderkoppDeepa WeerasekeraDaniel WeghuberWenbin WeiAneta WeresBo WernerPeter WhincupKurt WidhalmIndah WidyaheningAndrzej WiecekRainford WilksJohann WilleitPeter WilleitJulianne WilliamsTom WilsgaardBogdan WojtyniakRoy Wong-McclureAndrew WongJyh Eiin WongTien Yin WongJean WooMark WoodwardFrederick WuJianfeng WuLi Juan WuShouling WuHaiquan XuLiang XuNor Azwany YaacobUruwan YamborisutWeili YanLing YangXiaoguang YangD.M. WysockiNazan YardimMehdi YaseriTabara YasuharuXingwang YePanayiotis YiallourosMoein YoosefiAkihiro YoshiharaQi Sheng YouSan-Lin YouNovie Younger-ColemanSafiah Md YusofAhmad Faudzi YusoffLuciana ZaccagniVassilis ZafiropulosAhmad ZainuddinSeyed Rasoul ZakaviFarhad ZamaniSabina ZambonAntonis ZampelasHana ZamrazilováMaria Elisa ZapataAbdul Hamid ZargarKo Ko ZawTomasz ZdrojewskiTajana Zeljkovic VrkicYi ZengLuxia ZhangZhen-Yu ZhangDong ZhaoMing-Hui ZhaoWenhua ZhaoShiqi ZhenWei ZhengYingfeng ZhengBekbolat ZholdinMaigeng ZhouDan ZhuYanina ZocaloJulio Zuñiga CisnerosMonika ZuziakMajid Ezzati
• Organismes : Equipe AGING (CERPOP) Unité Mixte Internationale "Environnement Santé Sociétés" Equipe AGING (CERPOP) Nutrition et Alimentation des Populations aux Suds Nutrition et Alimentation des Populations aux Suds Nutrition et Alimentation des Populations aux Suds Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire
• Publié dans The Lancet le 02/11/2020

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Résumé : Background: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings: We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation: The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks.

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Fichiers liés : 07_11p1511_1524R3_(20TL2466).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/11/2020
• Auteurs : Philippe DebourdeauMohamed BelkacémiGuillaume EconomosEric AssenatWerner HilgersJulie CoussirouSfaya Kouidri UzanLéa VasquezAntoine DebourdeauJean Pierre DauresSebastien Salas
• Organismes : Institut Sainte Catherine [Avignon] Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 Ciblage thérapeutique en Oncologie Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génétique Moléculaire de Montpellier Institut Sainte Catherine [Avignon] Institut Sainte Catherine [Avignon] Institut Sainte Catherine [Avignon] Institut Sainte Catherine [Avignon] Institut Sainte Catherine [Avignon] Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 Service d’Oncologie Médicale [Hôpital de la Timone - APHM]
• Publié dans BMJ Palliative and supportive care le 27/10/2020

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Résumé : Objective Antitumour treatment in the last 2 weeks of death (ATT-W2) and a new regimen of ATT within 30 days of death (NATT-M1) are considered as aggressive end-of-life (EOL) care. We aimed to assess factors associated with inappropriate use of antitumour treatment (ATT) at EOL. Methods Data of patients with cancer who died in 2013, 2015, 2017 and 2019 in a single for-profit cancer centre were retrospectively analysed. ATT was divided into chemotherapy (CT), oral targeted therapy (OTT), hormonotherapy and immunotherapy (IMT). Results A total of 1282 patients were included. NATT-M1 was given to 197 (15.37%) patients, and 167 (13.03%) had an ATT-W2. Patients with a performance status of <2 and treated with CT had more both ATT- W2 (OR=2.45, 95% CI 1.65 to 3.65, and OR=10.29, 95% CI 4.70 to 22.6, respectively) and NATT-M1 (OR=2.01, 95% CI 1.40 to 2.90, and OR=8.41, 95% CI 4.46 to 15.86). Predictive factors of a higher rate of ATT-W2 were treatment with OTT (OR=19.08, 95% CI 7.12 to 51.07), follow-up by a medical oncologist (OR=1.49, 95% CI 1.03 to 2.17), miscellaneous cancer (OR=3.50, 95% CI 1.13 to 10.85) and length of hospital stay before death of <13 days (OR=1.92, 95% CI 1.32 to 2.79). Urinary tract and male genital cancers received less ATT-W2 (OR=0.38, 95% CI 0.16 to 0.89, and OR=0.40, 95% CI 0.16 to 0.99) and patients treated by IMT or with age <69 years more NATT-M1 (OR=19.21, 95% CI 7.55 to 48.8, and OR=1.69, 95% CI 1.20 to 2.37). Patients followed up by the palliative care team (PCT) had fewer ATT-W2 and NATT-M1 (OR=0.49, 95% CI 0.35 to 0.71, and OR=0.42, 95% CI 0.30 to 0.58). Conclusions Most recent ATT and access to a PCT follow-up are the two most important potentially modifiable factors associated with aggressive EOL in patients with cancer. Early integrated palliative oncology care could help to decrease futile ATT at EOL.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/11/2020
• Auteurs : Laura CifDiane DemaillyJean-Pierre LinKaty BarwickMario SaLucia AbelaSony MalhotraWui Kling ChongDora SteelAlba Sanchis-JuanAdeline NgohNatalie TrumpEsther MeyerXavier VasquesJulia RankinMeredith AllainCarolyn ApplegateSanaz Attaripour IsfahaniJulien Frédéric BaleineBettina BalintJennifer BassettiEmma L BapleKailash P BhatiaCatherine BlanchetLydie BurglenGilles CambonieEmilie Chan-SengSandra Chantot-BastaraudFabienne CyprienChristine CoubesVincent D’hardemareAsif DojaNathalie DorisonDiane DoummarMarisela Dy-HollinsEllyn FarrellyDavid FitzpatrickConor FearonElizabeth FiegBrent L. FogelEva FormanRachel FoxWilliam GahlSerena GalosiVictoria GonzalezTracey GravesAllison GregoryMark HallettHarutomo HasegawaSusan HayflickAda HamoshMarie HullySandra JansenSuh Young JeongJoel KrierSidney KrystalKishore KumarChloé LaurencinHane LeeGaëtan LescaLaurence Lion-FrançoisTimothy LynchNeil MahantJulian A Martinez-AgostoChristophe MilésiKelly MillsMichel MondainHugo Morales-BricenoJohn R. OstergaardSwasti PalJuan PallaisFrédérique PavillardPierre-François PerrigaultAndrea K. PetersenGustavo PoloGaëtan PoulenTuula RinneThomas RoujeauCaleb RogersAgathe RoubertieMichelle SahagianElise SchaeferLaila SelimRichard SelwayNutan SharmaRebecca SignerAriane SoldatosDavid A StevensonFiona StewartMichel TchanIshwar C VermaBert B.A. de VriesJenny WilsonDerek WongRaghda ZaitounDolly ZhenAnna ZnaczkoRussell C. DaleClaudio DegusmaoJennifer FriedmanVictor S.C. FungMary D. KingShekeeb S. MohammadLuis RohenaJeff L WaughCamilo ToroF. Lucy RaymondMaya TopfPhilippe CoubesKathleen GormanManju A Kurian
• Organismes : Service de Neurochirurgie [CHRU Montpellier] Université de Montpellier Service de Neurochirurgie [CHRU Montpellier] Université de Montpellier Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust Institute of Child Health [London] Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust Institute of Child Health [London] Birkbeck College [University of London] Institute of Child Health [London] Institute of Child Health [London] Great Ormond Street Hospital for Children [London] Cambridge University Hospitals - NHS University of Cambridge [Cambridge, UK] Institute of Child Health [London] Great Ormond Street Hospital for Children [London] Institute of Child Health [London] Institute of Child Health [London] IBM PSSC Montpellier - Innovation Lab. Royal Devon and Exeter Hospital [Exeter, UK] Stanford University Johns Hopkins University School of Medicine [Baltimore] National Institutes of Health [Bethesda, MD, USA] Centre Hospitalier Régional Universitaire [Montpellier] UCL Queen Square Institute of Neurology Heidelberg University Hospital [Heidelberg] Weill Medical College of Cornell University [New York] University of Exeter Medical School Royal Devon and Exeter Hospital [Exeter, UK] UCL Queen Square Institute of Neurology Centre Hospitalier Régional Universitaire [Montpellier] CHU Trousseau [APHP] Centre Hospitalier Régional Universitaire [Montpellier] Service de Neurochirurgie [CHRU Montpellier] Université de Montpellier Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Service de Neurochirurgie [CHRU Montpellier] Université de Montpellier Département de génétique médicale, maladies rares et médecine personnalisée [CHU Montpellier] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Children's Hospital of Eastern Ontario [Ottawa, Canada] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital CHU Trousseau [APHP] Massachusetts General Hospital [Boston] Harvard Medical School [Boston] Stanford University The University of Edinburgh Mater Misericordiae University Hospital Brigham & Women’s Hospital [Boston] David Geffen School of Medicine [Los Angeles] Children's Health Ireland at Temple Street Oregon Health and Science University [Portland] National Institutes of Health [Bethesda, MD, USA] Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] Service de Neurochirurgie [CHRU Montpellier] Université de Montpellier North West Anglia NHS Foundation Trust [ Huntingdon, UK] Oregon Health and Science University [Portland] National Institutes of Health [Bethesda, MD, USA] Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust Oregon Health and Science University [Portland] Johns Hopkins University School of Medicine [Baltimore] Hôpital Necker - Enfants Malades [AP-HP] Radboud University Medical Center [Nijmegen] Oregon Health and Science University [Portland] Brigham & Women’s Hospital [Boston] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Garvan Institute of medical research The University of Sydney Royal North Shore Hospital Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] David Geffen School of Medicine [Los Angeles] Centre Hospitalier Lyon Sud [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] University College Dublin [Dublin] Mater Misericordiae University Hospital Westmead Hospital [Sydney] David Geffen School of Medicine [Los Angeles] Centre Hospitalier Régional Universitaire [Montpellier] Johns Hopkins University School of Medicine [Baltimore] Centre Hospitalier Régional Universitaire [Montpellier] Children's Hospital [Westmead, Australia] The University of Sydney Aarhus University Hospital Sir Ganga Ram Hospital Brigham & Women’s Hospital [Boston] Département d'Anesthésie-Réanimation [Gui de Chauliac - CHU Montpellier] Département d'Anesthésie-Réanimation [Gui de Chauliac - CHU Montpellier] Randall Children's Hospital [Portland] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Service de Neurochirurgie [CHRU Montpellier] Université de Montpellier Radboud University Medical Center [Nijmegen] Service de Neurochirurgie [CHRU Montpellier] Oregon Health and Science University [Portland] Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier Rady Children's Hospital University of California [San Diego] Hôpitaux Universitaires de Strasbourg Cairo University King's College Hospital Massachusetts General Hospital [Boston] Harvard Medical School [Boston] Brigham and Women's Hospital [Boston] David Geffen School of Medicine [Los Angeles] National Institutes of Health [Bethesda, MD, USA] Stanford University Belfast Health and Social Care Trust The University of Sydney Westmead Hospital [Sydney] Sir Ganga Ram Hospital Radboud University Medical Center [Nijmegen] Oregon Health and Science University [Portland] David Geffen School of Medicine [Los Angeles] جامعة عين شمس - Ain Shams University [Cairo] Oregon Health and Science University [Portland] Belfast Health and Social Care Trust Children's Hospital [Westmead, Australia] The University of Sydney Boston Children's Hospital Rady Children's Hospital Boston Children's Hospital Rady Children’s Institute of Genomic Medicine [La Jolla, CA, USA] Westmead Hospital [Sydney] The University of Sydney Children's Health Ireland at Temple Street University College Dublin [Dublin] The University of Sydney Children's Hospital [Westmead, Australia] University of Texas Health Science Center University of Texas Southwestern Medical Center National Institutes of Health [Bethesda, MD, USA] Cambridge University Hospitals - NHS Cambridge Institute for Medical Research Birkbeck College [University of London] Service de Neurochirurgie [CHRU Montpellier] Université de Montpellier Institute of Child Health [London] Great Ormond Street Hospital for Children [London] Institute of Child Health [London] Great Ormond Street Hospital for Children [London]
• Publié dans Brain - A Journal of Neurology le 29/10/2020

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Résumé : Heterozygous mutations in KMT2B are associated with an early-onset, progressive and often complex dystonia (DYT28). Key characteristics of typical disease include focal motor features at disease presentation, evolving through a caudocranial pattern into generalized dystonia, with prominent oromandibular, laryngeal and cervical involvement. Although KMT2B-related disease is emerging as one of the most common causes of early-onset genetic dystonia, much remains to be understood about the full spectrum of the disease. We describe a cohort of 53 patients with KMT2B mutations, with detailed delineation of their clinical phenotype and molecular genetic features. We report new disease presentations, including atypical patterns of dystonia evolution and a subgroup of patients with a non-dystonic neurodevelopmental phenotype. In addition to the previously reported systemic features, our study has identified co-morbidities, including the risk of status dystonicus, intrauterine growth retardation, and endocrinopathies. Analysis of this study cohort (n = 53) in tandem with published cases (n = 80) revealed that patients with chromosomal deletions and protein truncating variants had a significantly higher burden of systemic disease (with earlier onset of dystonia) than those with missense variants. Eighteen individuals had detailed longitudinal data available after insertion of deep brain stimulation for medically refractory dystonia. Median age at deep brain stimulation was 11.5 years (range: 4.5–37.0 years). Follow-up after deep brain stimulation ranged from 0.25 to 22 years. Significant improvement of motor function and disability (as assessed by the Burke Fahn Marsden’s Dystonia Rating Scales, BFMDRS-M and BFMDRS-D) was evident at 6 months, 1 year and last follow-up (motor, P = 0.001, P = 0.004, and P = 0.012; disability, P = 0.009, P = 0.002 and P = 0.012). At 1 year post-deep brain stimulation, >50% of subjects showed BFMDRS-M and BFMDRS-D improvements of >30%. In the long-term deep brain stimulation cohort (deep brain stimulation inserted for >5 years, n = 8), improvement of >30% was maintained in 5/8 and 3/8 subjects for the BFMDRS-M and BFMDRS-D, respectively. The greatest BFMDRS-M improvements were observed for trunk (53.2%) and cervical (50.5%) dystonia, with less clinical impact on laryngeal dystonia. Improvements in gait dystonia decreased from 20.9% at 1 year to 16.2% at last assessment; no patient maintained a fully independent gait. Reduction of BFMDRS-D was maintained for swallowing (52.9%). Five patients developed mild parkinsonism following deep brain stimulation. KMT2B-related disease comprises an expanding continuum from infancy to adulthood, with early evidence of genotype-phenotype correlations. Except for laryngeal dysphonia, deep brain stimulation provides a significant improvement in quality of life and function with sustained clinical benefit depending on symptoms distribution.

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Fichiers liés : 41872.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/11/2020
• Auteurs : Cornelis van LeeuwenJean-Christophe BarbePhilippe DarrietOlivier GeffroyEric GomèsSabine GuillaumiePierre HelwiJustine LaboyrieGeorgia LytraNicolas Le MennStéphanie Marchand-MarionMagali PicardAlexandre PonsArmin SchüttlerCécile Thibon
• Organismes : Institut des Sciences de la Vigne et du Vin [Villenave d'Ornon] Ecophysiologie et Génomique Fonctionnelle de la Vigne Unité de Recherche Oenologie [Villenave d'Ornon] Unité de Recherche Oenologie [Villenave d'Ornon] Ecole d'Ingénieurs de Purpan Physiologie, Pathologie et Génétique Végétales Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Texas A&M University System Unité de Recherche Oenologie [Villenave d'Ornon] Unité de Recherche Oenologie [Villenave d'Ornon] Unité de Recherche Oenologie [Villenave d'Ornon] Unité de Recherche Oenologie [Villenave d'Ornon] Institut des Sciences Moléculaires Unité de Recherche Oenologie [Villenave d'Ornon] Hochschule Geisenheim University Unité de Recherche Oenologie [Villenave d'Ornon]
• Publié dans OENO One le 28/10/2020

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Résumé : Terroir is about the link between wine and its origin. It has long been understood by sensory evaluation that the taste of wine from a given variety can be related to its origins. Specific organoleptic characteristics of wine are influenced by environmental factors such as soil and climate. By deconstructing the effect of measurable soil and climate parameters on grape and wine aroma compounds, the terroir effect on wine typicity can be better understood. Climate influences on vine development and grape ripening are mainly associated with temperature, radiation and rainfall, while soil influences are primarily associated with water availability and nitrogen supply. Significant advances have been made over recent years in understanding wine aromas and their molecular basis and influences of climate and soil on a wide range of molecules responsible for wine aroma expression. This article aims to review these recent research advances to obtain a more comprehensive understanding of how terroir influences wine typicity. The effect of terroir on wine quality and typicity is sometimes considered intangible and difficult to explain on a scientific basis. By combining agronomic, analytical and sensory approaches, however, this review shows that the terroir effect is mediated by measurable factors that can easily be monitored in the vineyard. Assessment of the results compiled by this review allows the suggestion that terroir expression at specific sites might be maximized by choosing appropriate plant material in relation to soil and climate, by acting on manageable parameters like vine water and nitrogen status, or by implementing canopy management to modify microclimate in the bunch zone.

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Fichiers liés : 2020-van Leeuwen-OenoOne.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/11/2020
• Auteurs : Anne Darmon-CurtiFrançois DarmonSophie EdouardAurélie HennebiqueThomas GuimardGuillaume Martin-BlondelTimothée KlopfensteinJean-Philippe TalarminDidier RaoultMax MaurinPierre-Edouard Fournier
• Organismes : Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection École nationale des ponts et chaussées Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut de Biologie et de Pathologie [CHU Grenoble] Centre National de Référence des Francisella [CHU Grenoble] CHU La Roche sur Yon Centre de Physiopathologie Toulouse Purpan Service Maladies infectieuses et tropicales [CHU Toulouse] service de maladies infectieuses CHU J Minjoz Besancon Centre Hospitalier Intercommunal de Cornouaille [Quimper] Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut de Biologie et de Pathologie [CHU Grenoble] Centre National de Référence des Francisella [CHU Grenoble] Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes
• Publié dans Open Forum Infectious Diseases le 22/10/2020

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Fichiers liés : ofaa440.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 02/11/2020
• Auteurs : Pierre-Jean RoumanetNathalie JarrouxLaurent GoujardJean Le PetitYann RaoulVéronique BennevaultPhilippe Guégan
• Organismes : Laboratoire Analyse, Modélisation et Matériaux pour la Biologie et l'Environnement Laboratoire Analyse, Modélisation et Matériaux pour la Biologie et l'Environnement Institut méditerranéen de biodiversité et d'écologie marine et continentale Institut méditerranéen de biodiversité et d'écologie marine et continentale Oléon SAS (FRANCE) Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire
• Publié dans ACS Sustainable Chemistry & Engineering le 22/10/2020

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Résumé : A new family of bio-based linear polyesters from oleic acid was developed by a bulk polymerization process. First, efficient chemical pathways were selected to synthesize three monomer derivatives from 1,18-(Z)-octadec-9-enedioic acid, allowing the synthesis of four polyesters that differ by the number of double bonds along the polymer backbone. After the analysis of the structure of the polymers, their thermal properties and their biodegradability were investigated. It was shown that the melting temperature of the polyesters increased with the decrease in the unsaturation content in the repeat units of the polymers and they have very low glass-transition temperatures. A biodegradation process was also highlighted for poly(1,18-(Z)-octadec-9-enylene 1,18-(Z)-octadec-9-enedioate) and poly(1,18-octadecylene 1,18-octadecanedioate). Based on their thermal features, these biodegradable polyesters can represent an alternative of the synthetic polymers derived from petroleum hydrocarbons, such as low-density polyethylene.

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• Type de publi. : Article dans une revue
• Date de publi. : 02/11/2020
• Auteurs : Zied AffesEric-Jean BouvardPierre LevyClaire DussauleGilles GrateauJean-Philippe Haymann
• Organismes : Laboratoire d'Economie et de Gestion des Organisations de Santé Laboratoire d'Economie et de Gestion des Organisations de Santé Laboratoire d'Economie et de Gestion des Organisations de Santé Centre Hospitalier Sud Francilien CHU Tenon [AP-HP] Maladies génétiques d'expression pédiatrique CHU Tenon [AP-HP]
• Publié dans Journal of Clinical Neurophysiology le 01/11/2020

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Résumé : A 78-year-old man was admitted for acute confusion. At initial investigation physical examination, blood and cerebrospinal fluid tests were unremarkable and EEG showed synchronous bifrontal periodic discharges, an evocative pattern of encephalitis. Coronavirus disease 2019 was diagnosed later after fever onset. Isolated mild confusion may thus be an initial clinical picture of Coronavirus disease 2019 infection.

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Fichiers liés : Affes et al. - 2021 - COVID-19 Presenting With Confusion An Unusual but.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2020
• Auteurs : Anna ÅkerlundEmma JonassonErika MatuschekLena SerranderMartin SundqvistGunnar KahlmeterEsad DzajicDennis Schrøder HansenHarlotte Nielsen AgergaardAnu Pätäri-SampoRaija ManninenJuha GrönroosJean-Philippe RasigadeWaël SalkaPierre H. BoyerEvangelia LebessiNikolaos ZapaniotisEfi PetinakiIris SpiliopoulouFevronia KolonitsiouKristjan Orri HelgasonJean BrazilEleonora RiccobonoGiuliana Lo CascioLaura MaccacaroHelge KolstadTorunn Sneide HaukelandPirkko-Liisa KellokumpuAndreas Fossum MjøenStåle ToftelandBerit HarbakSusanne Hartvig HartzenSiri Haug HänsgenKarianne Wiger GammelsrudUnni SkolbekkenNina MichalsenAnita Løvås BrekkenBodil PedersenBrian GuennigsmanAstrid LiaAnn Kristin BergFrancesco MarcoCristina PitartPilar EgeaJose Luis Cortes-CuevasJesus MachucaMartin WietzkeMagdalena DammströmRoger GranströmMaria CorneliussonMarita SkarstedtKarin FrykfeldtCarina Lindqvist IvarssonAdam SergejevSusanna HagströmUlrika LidénJohan RydbergHanna RamströmInga FrödingEvangelos Alexandros PetropoulosKarolina IninbergsShah JalalAnna-Lena Sundqvist PerssonNina KamenskaKerstin GranlundAnna-Karin SmekalAnna HillGunilla RådbergGabriel HeymanLized RodriguezLisa VennbergGülşen HazırolanIsin AkyarGelmez Gülşen AltınkanatAyse Nur Sari KaygisizEsad DzajicDennis Schrøder HansenHarlotte Nielsen AgergaardAnu Pätäri-SampoRaija ManninenJuha GrönroosJean-Philippe RasigadeWaël SalkaPierre BoyerEvangelia LebessiNikolaos ZapaniotisEfi PetinakiIris SpiliopoulouFevronia KolonitsiouKristjan Orri HelgasonJean BrazilEleonora RiccobonoGiuliana Lo CascioLaura MaccacaroHelge KolstadTorunn Sneide HaukelandPirkko-Liisa KellokumpuAndreas Fossum MjøenStåle ToftelandBerit HarbakSusanne Hartvig HartzenSiri Haug HänsgenKarianne Wiger GammelsrudUnni SkolbekkenNina MichalsenAnita Løvås BrekkenBodil PedersenBrian GuennigsmanAstrid LiaAnn Kristin BergFrancesco MarcoCristina PitartPilar EgeaJose Luis Cortes-CuevasJesus MachucaMartin WietzkeMagdalena DammströmRoger GranströmMaria CorneliussonMarita SkarstedtKarin FrykfeldtCarina Lindqvist IvarssonAdam SergejevSusanna HagströmUlrika LidénJohan RydbergHanna RamströmInga FrödingEvangelos Alexandros PetropoulosKarolina IninbergsShah JalalAnna-Lena Sundqvist PerssonNina KamenskaKerstin GranlundAnna-Karin SmekalAnna HillGunilla RådbergGabriel HeymanLized RodriguezLisa VennbergGülşen HazırolanIsin AkyarGelmez Gülşen AltınkanatAyse Nur Sari Kaygisiz
• Organismes : Växjö Central Hospital Dept. of Clinical Microbiology Örebro University Växjö Central Hospital Institut des Agents Infectieux [Lyon] Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Département de Microbiologie Clinique [HCL Groupement Hospitalier Nord, Lyon] Centre National de Référence Borréliose
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Objectives When bloodstream infections are caused by resistant bacteria, rapid antimicrobial susceptibility testing (RAST) is important for adjustment of therapy. The EUCAST RAST method, directly from positive blood cultures, was validated in a multi-laboratory study in Europe. Methods RAST was performed in 40 laboratories in northern Europe (NE) and 15 in southern Europe (SE) from clinical blood cultures positive for Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus or Streptococcus pneumoniae. Categorical results at 4, 6 and 8 h of incubation were compared with results for EUCAST standard 16–20 h disc diffusion. The method, preliminary breakpoints and the performance of the laboratories were evaluated. Results The total number of isolates was 833/318 in NE/SE. The number of zone diameters that could be read (88%, 96% and 99%) and interpreted (70%, 81% and 85%) increased with incubation time (4, 6 and 8 h). The categorical agreement was acceptable, with total error rates in NE/SE of 2.4%/4.9% at 4 h, 1.1%/3.5% at 6 h and 1.1%/3.3% at 8 h. False susceptibility at 4, 6 and 8 h of incubation was below 0.3% and 1.1% in NE and SE, respectively, and the corresponding percentages for false resistance were below 1.9% and 2.8%. After fine-tuning breakpoints, more zones could be interpreted (73%, 89% and 93%), with only marginally affected error rates. Conclusions The EUCAST RAST method can be implemented in routine laboratories without major investments. It provides reliable antimicrobial susceptibility testing results for relevant bloodstream infection pathogens after 4–6 h of incubation.

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