Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2020
• Auteurs : Audrey MonninNicolas NagotSabrina Eymard-DuvernayNicolas MedaJames TumwineThorkild TylleskärPhilippe Van De PerreJean-Pierre Moles
• Organismes : Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections Pathogénèse et contrôle des infections chroniques (PCCI) Centre Muraz [Bobo-Dioulasso, Burkina Faso] Makerere University [Kampala, Ouganda] University of Bergen Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Fichiers liés : jcm-09-03680.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/10/2020
• Auteurs : Guillaume LassaillyRobert CaiazzoLine-Carolle Ntandja-WandjiViviane GnemmiGregory BaudHelene VerkindtMassih NingarhariAlexandre LouvetEmmanuelle LeteurtreVioleta RaverdySébastien DharancyFrançois PattouPhilippe Mathurin
• Organismes : Hôpital Claude Huriez [Lille] Institute for Translational Research in Inflammation - U 1286 Recherche translationnelle sur le diabète - U 1190 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Lille Neurosciences & Cognition - U 1172 Recherche translationnelle sur le diabète - U 1190 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Lille Inflammation Research International Center - U 995 Centre Hospitalier Régional Universitaire [CHU Lille] Lille Inflammation Research International Center - U 995 Centre Hospitalier Régional Universitaire [CHU Lille] Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Recherche translationnelle sur le diabète - U 1190 Centre Hospitalier Régional Universitaire [CHU Lille] Lille Inflammation Research International Center - U 995 Centre Hospitalier Régional Universitaire [CHU Lille] Recherche translationnelle sur le diabète - U 1190 Centre Hospitalier Régional Universitaire [CHU Lille] Lille Inflammation Research International Center - U 995 Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Gastroenterology le 25/10/2020

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Résumé : Background and aims: Studies are needed to determine the long-term effects of bariatric surgery for patients with nonalcoholic steatohepatitis (NASH). We evaluated sequential liver samples, collected the time of bariatric surgery and 1 and 5 years later, to assess the long-term effects of bariatric surgery in patients with NASH.Methods: We performed a prospective study of 180 severely obese patients with biopsy-proven NASH, defined by the NASH clinical research network histologic scores. The patients underwent bariatric surgery at a single center in France and were followed for 5 years. We obtained liver samples from 125 of 169 patients (76%) having reached 1 year and 64 of 94 patients (68%) having reached 5 years after surgery. The primary endpoint was the resolution of NASH without worsening of fibrosis at 5 years. Secondary end points were improvement in fibrosis (reduction of ≥1 stage) at 5 years and regression of fibrosis and NASH at 1 and 5 years.Results: At 5 years after bariatric surgery, NASH was resolved, without worsening fibrosis, in samples from 84% of patients (n = 64; 95% confidence interval, 73.1%-92.2%). Fibrosis decreased, compared with baseline, in samples from 70.2% of patients (95% CI, 56.6%-81.6%). Fibrosis disappeared from samples from 56% of all patients (95% CI, 42.4%-69.3%) and from samples from 45.5% of patients with baseline bridging fibrosis. Persistence of NASH was associated with no decrease in fibrosis and less weight loss (reduction in body mass index of 6.3 ± 4.1 kg/m2 in patients with persistent NASH vs reduction of 13.4 ± 7.4 kg/m2; P = .017 with resolution of NASH). Resolution of NASH was observed at 1 year after bariatric surgery in biopsies from 84% of patients, with no significant recurrence between 1 and 5 years (P = .17). Fibrosis began to decrease by 1 year after surgery and continued to decrease until 5 years (P < .001).Conclusions: In a long-term follow-up of patients with NASH who underwent bariatric surgery, we observed resolution of NASH in liver samples from 84% of patients 5 years later. The reduction of fibrosis is progressive, beginning during the first year and continuing through 5 years.

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Fichiers liés : S0016508520347582.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/10/2020
• Auteurs : Julie Teresa ShapiroGilles LeboucherAnne-Florence Myard-DuryPascale GirardoAnatole LuzzatiMélissa MaryJean-François SauzonBénédicte LafayOlivier DauwalderFrédéric LaurentGerard LinaChristian ChidiacSandrine Couray-TargeFrancois VandeneschJean-Pierre FlandroisJean-Philippe Rasigade
• Organismes : Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Département de Pharmacie, Hospices Civils de Lyon Département d'Information Médicale, Hospices Civils de Lyon, 162, avenue Lacassagne, 69424 Lyon Cedex 03 Institut des Agents Infectieux [Lyon] Institut des Agents Infectieux [Lyon] Institut des Agents Infectieux [Lyon] Institut des Agents Infectieux [Lyon] Université de Lyon Université Claude Bernard Lyon 1 Centre National de la Recherche Scientifique Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Bioinformatique, phylogénie et génomique évolutive [LBBE] Département PEGASE [LBBE] Institut des Agents Infectieux [Lyon] Institut des Agents Infectieux [Lyon] Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Institut des Agents Infectieux [Lyon] Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Service des maladies infectieuses et tropicales Département d'Information Médicale, Hospices Civils de Lyon, 162, avenue Lacassagne, 69424 Lyon Cedex 03 Institut des Agents Infectieux [Lyon] Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] BioInformatique et BioStatistiques [CIRI] Institut des Agents Infectieux [Lyon] Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI]
• Publié dans eLife le 23/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/10/2020
• Auteurs : Olivier CaumontOlivier PayrastreBrice BoudevillainFrançois BourginFrançois BouttierMaryse Charpentier-NoyerVéronique DucrocqAxelle FleuryEric GaumeNabil HociniBruno JanetPierre JavelleMaxime Jay-AllemandDimitri LagueAlexane LovatDavid MoncoulonJean-Philippe NaulinPierre NicolleDaniela PeredoCharles PerrinLéa PoinsignonFrédéric PonsMaria-Helena RamosIsabelle RuinGalateia Terti
• Organismes : Centre national de recherches météorologiques Eau et Environnement Institut des Géosciences de l’Environnement Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Centre national de recherches météorologiques Eau et Environnement Centre national de recherches météorologiques Centre national de recherches météorologiques Eau et Environnement Eau et Environnement Ministère de la transition énergétique et de la cohésion des territoires Service Central d'Hydrométéorologie et d'Appui à la Prévision des Inondations Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience Géosciences Rennes Centre national de recherches météorologiques Caisse Centrale de Réassurance Caisse Centrale de Réassurance Eau et Environnement Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Centre d'Etudes et d'Expertise sur les Risques, l'Environnement, la Mobilité et l'Aménagement - Direction Méditerranée Centre d'Etudes et d'Expertise sur les Risques, l'Environnement, la Mobilité et l'Aménagement - Direction Méditerranée Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Institut des Géosciences de l’Environnement Institut des Géosciences de l’Environnement

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• Type de publi. : Article dans une revue
• Date de publi. : 26/10/2020
• Auteurs : Michel RamonetPhilippe CiaisFrancesco ApadulaJakub BartyzelAna BastosPeter BergamaschiPierre-Éric BlancDominik BrunnerLuigi Caracciolo Di TorchiaroloFrancescopiero CalzolariHuilin ChenLukasz ChmuraAurélie ColombSébastien ConilPaolo CristofanelliEmilio CuevasRoger CurcollMarc DelmotteAlcide Di SarraLukas EmmeneggerGrant ForsterArnoud FrumauChristoph GerbigFrançois GheusiSamual HammerLaszlo HaszpraJuha HatakkaLynn HazanMichael HeliaszStephan HenneArjan HensenOve HermansenPetri KeronenRigel KiviKaterina KomínkováDagmar KubistinOlivier LaurentTuomas LaurilaJost LavricIrene LehnerKari LehtinenAri LeskinenMarkus LeuenbergerIngeborg LevinMatthias LindauerMorgan LopezC Lund MyhreIvan MammarellaGiovanni MancaAndrew ManningMichal MarekPer MarklundDamien MartinFrank MeinhardtNikolaos MihalopoulosMeelis MölderJosep MorguiJaroslaw NeckiSimon O'DohertyColin O'DowdMikaell Ottosson LöfveniusCarole PhilipponSalvatore PiacentinoJean-Marc PichonChristian Plass-DuelmerAlex ResovskyLeonard RivierXavier RodóMahesh Kumar ShaHubertus ScheerenDamiano SferlazzoT. Gerard SpainKieran StanleyMartin SteinbacherPamela TrisolinoAlex VermeulenGabriela VítkováDietmar WeyrauchIrène Xueref-RemyKhalil YalaC. Yver Kwok
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC Ricerca sul Sistema Energetico AGH University of Science and Technology [Krakow, PL] Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München European Commission - Joint Research Centre [Ispra] Institut Pythéas Institut méditerranéen de biodiversité et d'écologie marine et continentale Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] Italian Air Force Meteorological Service CNR Institute of Atmospheric Sciences and Climate Centre for Environmental and Climate Research [Lund] AGH University of Science and Technology [Krakow, PL] Laboratoire de Météorologie Physique Agence Nationale pour la Gestion des Déchets Radioactifs CNR Institute of Atmospheric Sciences and Climate Izaña Atmospheric Research Center Institut de Ciencia i Tecnologia Ambientals Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] Centre for Ocean and Atmospheric Sciences [Norwich] The Netherlands Organisation for Applied Scientific Research Max-Planck-Gesellschaft Laboratoire d'aérologie Institut für Umweltphysik [Heidelberg] Research Centre for Astronomy and Earth Sciences [Budapest] Finnish Meteorological Institute Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC Centre for Environmental and Climate Research [Lund] Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] The Netherlands Organisation for Applied Scientific Research Norsk Institutt for Luftforskning Institute for Atmospheric and Earth System Research Finnish Meteorological Institute Global Change Research Centre Meteorologisches Observatorium Hohenpeißenberg Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Finnish Meteorological Institute Max-Planck-Gesellschaft Centre for Environmental and Climate Research [Lund] University of Eastern Finland = Itä-Suomen Yliopisto = Östra Finlands universitet Finnish Meteorological Institute University of Eastern Finland = Itä-Suomen Yliopisto = Östra Finlands universitet Finnish Meteorological Institute Climate and Environmental Physics [Bern] Institut für Umweltphysik [Heidelberg] Meteorologisches Observatorium Hohenpeißenberg Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Norsk Institutt for Luftforskning Institute for Atmospheric and Earth System Research European Commission - Joint Research Centre [Ispra] Centre for Ocean and Atmospheric Sciences [Norwich] Global Change Research Centre Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet ENVIRONMENTAL PROTECTION AGENCY DUBLIN IRL German Federal Environmental Agency / Umweltbundesamt Environmental Chemical Processes Laboratory [Heraklion] Department of Physical Geography and Ecosystem Science Institut de Ciencia i Tecnologia Ambientals AGH University of Science and Technology [Krakow, PL] University of Bristol [Bristol] Centre for Climate and Air Pollution Studies [Galway] Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Italian National agency for new technologies, Energy and sustainable economic development [Frascati] Laboratoire de Météorologie Physique Deutscher Wetterdienst, Hohenpeißenberg Meteorological Observatory Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC Barcelona Institute for Global Health [Barcelona, Spain] ICREA Infection Biology Laboratory Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique Centre for Isotope Research [Groningen] Italian National agency for new technologies, Energy and sustainable economic development [Frascati] Centre for Climate and Air Pollution Studies [Galway] ICOS-RAMCES Institute for Atmospheric and Environmental Sciences [Frankfurt/Main] Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] CNR Institute of Atmospheric Sciences and Climate Integrated Carbon Observation System Global Change Research Centre Deutscher Wetterdienst, Hohenpeißenberg Meteorological Observatory Institut méditerranéen de biodiversité et d'écologie marine et continentale Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC
• Publié dans Philosophical Transactions of the Royal Society B: Biological Sciences le 02/11/2020

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Résumé : During the summer of 2018, a widespread drought developed over Northern and Central Europe. The increase in temperature and the reduction of soil moisture have influenced carbon dioxide (CO2) exchange between the atmosphere and terrestrial ecosystems in various ways, such as a reduction of photosynthesis, changes in ecosystem respiration, or allowing more frequent fires. In this study, we characterize the resulting perturbation of the atmospheric CO2 seasonal cycles. 2018 has a good coverage of European regions affected by drought, allowing the investigation of how ecosystem flux anomalies impacted spatial CO2 gradients between stations. This density of stations is unprecedented compared to previous drought events in 2003 and 2015, particularly thanks to the deployment of the Integrated Carbon Observation System (ICOS) network of atmospheric greenhouse gas monitoring stations in recent years. Seasonal CO2 cycles from 48 European stations were available for 2017 and 2018. Earlier data were retrieved for comparison from international databases or national networks. Here, we show that the usual summer minimum in CO2 due to the surface carbon uptake was reduced by 1.4 ppm in 2018 for the 10 stations located in the area most affected by the temperature anomaly, mostly in Northern Europe. Notwithstanding, the CO2 transition phases before and after July were slower in 2018 compared to 2017, suggesting an extension of the growing season, with either continued CO2 uptake by photosynthesis and/or a reduction in respiration driven by the depletion of substrate for respiration inherited from the previous months due to the drought. For stations with sufficiently long time series, the CO2 anomaly observed in 2018 was compared to previous European droughts in 2003 and 2015. Considering the areas most affected by the temperature anomalies, we found a higher CO2 anomaly in 2003 (+3 ppm averaged over 4 sites), and a smaller anomaly in 2015 (+1 ppm averaged over 11 sites) compared to 2018. This article is part of the theme issue ‘Impacts of the 2018 severe drought and heatwave in Europe: from site to continental scale’.

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Fichiers liés : Ramonet et al Philosophical Transcations Royal Society 2020.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/10/2020
• Auteurs : Philippe PonelJean-Pierre Hébrard
• Organismes : Institut méditerranéen de biodiversité et d'écologie marine et continentale Institut méditerranéen de biodiversité et d'écologie marine et continentale
• Publié dans Annales de la Société des Sciences Naturelles et d'Archéologie de Toulon et du Var le 18/12/2018

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Fichiers liés : Ponel et al SSNATV 56-76 2020.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/10/2020
• Auteurs : Christelle GrisezLeslie BottariFrançoise PrévotJean-Pierre AlzieuEmmanuel LiénardFabien CorbiereMarie RameilXavier DesclauxChristophe LaczChristian BoulonJulie PetermannJeanne Le MévelCarine VilardellPhilippe Jacquiet
• Organismes : Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Laboratoire Vétérinaire Départemental de l'Ariège Innovations Thérapeutiques et Résistances Interactions hôtes-agents pathogènes [Toulouse] Laboratoire Vétérinaire Départemental de l'Ariège Laboratoire Vétérinaire Départemental de l'Ariège Fédération Régionale des Groupements de Défense Sanitaire d'Occitanie Groupement de Défense Sanitaire de l'Ardèche Groupement de Défense contre les Maladies des Animaux de l'Indre Interactions hôtes-agents pathogènes [Toulouse] Groupement de Défense Sanitaire (GDS) des Alpes de Haute Provence Interactions hôtes-agents pathogènes [Toulouse]
• Publié dans Parasites & Vectors le 08/10/2020

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Résumé : Background: Bovine besnoitiosis, an emerging disease in Europe that can be transmitted by vectors, is caused by the apicomplexan Besnoitia besnoiti . Bovine besnoitiosis is difficult to control due to the complexity of its diagnosis in the acute stage of the disease, poor treatment success and chronically asymptomatic cattle acting as parasite reservoirs. When serological prevalence is low, detection and specific culling of seropositive cattle is feasible; however, economic considerations preclude this approach when serological prevalence is high. The aims of this study were to evaluate the accuracy of detection of super-spreaders in highly infected herds and to test their selective elimination as a new control strategy for bovine besnoitiosis. Methods: Previous real-time PCR analyses performed on skin tissues from 160 asymptomatic animals sampled at slaughterhouses showed that the tail base was the best location to evaluate the dermal parasite DNA load. All seropositive animals ( n = 518) from eight dairy or beef cattle farms facing a high serological prevalence of besnoitiosis were sampled at the tail base and their skin sample analysed by real-time PCR. A recommendation of rapid and selective culling of super-spreaders was formulated and provided to the cattle breeders. Subsequent serological monitoring of naïve animals was used to evaluate the interest of this control strategy over time. Results: Among the 518 seropositive animals, a low proportion of individuals (14.5%) showed Cq values below 36, 17.8% had doubtful results (36 < Cq ≤ 40) and 67.8% had negative PCR results. These proportions were grossly similar on the eight farms, regardless of their production type (beef or dairy cattle), size, geographical location or history of besnoitiosis. Within two weeks of the biopsy, the rapid culling of super-spreaders was implemented on only three farms. The numbers of newly infected animals were lower on these farms compared to those where super-spreaders were maintained in the herd. Conclusions Real-time PCR analyses performed on skin biopsies of seropositive cattle showed huge individual variabilities in parasite DNA load. The rapid culling of individuals considered as super-spreaders seems to be a new and encouraging strategy for bovine besnoitiosis control.

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Fichiers liés : s13071-020-04405-7.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/10/2020
• Auteurs : Pierre Soler-CouteauxJean-Philippe Strebler
• Organismes : Université de Strasbourg Centre d'études internationales et européennes
• Publié dans Revue de droit immobilier. Urbanisme - construction le 30/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 20/10/2020
• Auteurs : Raphaël P MartinsJean-Marie UrienNicolas BarbarotGuillaume RieulJean-Marc SellalLionel BorellaNicolas ClementyArnaud BissonCharles GuenanciaAudrey SagnardStéphane SchumacherEstelle GandjbakhchJosselin DuchateauRomain TixierAngélique GoeppDavid HamonNicolas LelloucheLaure Champ-RigotPaul MilliezEloi MarijonEmilie VarletRodrigue GarciaBruno DegandPierre BoujuPhilippe MaboChristophe LeclercqNathalie BeharDominique PavinChristian de ChillouFrederic SacherVincent Galand
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Circulation le 29/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 20/10/2020
• Auteurs : Louis BernardGuillaume DesoubeauxElsa Bodier-MontagutelliJeoffrey PardessusDeborah BreaLaurine AllimonnierSébastien EymieuxPierre-Ivan RaynalVirginie VasseurLaurent VecellioLudovic MathéAntoine GuillonPhilippe LanotteJérémie PourchezPaul O VerhoevenStéphane EsnoufMuriel FerryNicolas EterradossiYannick BlanchardPaul Alun BrownPhilippe RoingeardJean-Pierre AlcarazPhilippe CinquinMustapha Si-TaharNathalie Heuzé-Vourc’h
• Organismes : Service de Médecine Interne et Maladies Infectieuses [Tours] Université de Tours Université de Tours Centre Hospitalier Régional Universitaire de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre Hospitalier Régional Universitaire de Tours Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents Université de Tours Centre Hospitalier Régional Universitaire de Tours Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Régional Universitaire de Tours Université de Tours Service de bactériologie et d'hygiène hospitalière [Tours] Infectiologie et Santé Publique Santé Ingénierie Biologie Saint-Etienne Groupe Immunité des Muqueuses et Agents Pathogènes Service des Agents Infectieux et Hygiène [CHU Saint-Etienne] Service d'Etudes du Comportement des Radionucléides Service d'Etudes du Comportement des Radionucléides Laboratoire de Ploufragan-Plouzané-Niort [ANSES] Laboratoire de Ploufragan-Plouzané-Niort [ANSES] Laboratoire de Ploufragan-Plouzané-Niort [ANSES] Université de Tours Centre Hospitalier Régional Universitaire de Tours Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents Systèmes Nanobiotechnologiques et Biomimétiques Systèmes Nanobiotechnologiques et Biomimétiques Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours]
• Publié dans Frontiers in Medicine le 01/11/2020

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Résumé : Background: The coronavirus infectious disease-2019 (COVID-19) pandemic has led to an unprecedented shortage of healthcare resources, primarily personal protective equipment like surgical masks, and N95/filtering face piece type 2 (FFP2) respirators.Objective: Reuse of surgical masks and N95/FFP2 respirators may circumvent the supply chain constraints and thus overcome mass shortage. Methods, design, setting, and measurement: Herein, we tested the effects of dry- and moist-air controlled heating treatment on structure and chemical integrity, decontamination yield, and filtration performance of surgical masks and FFP2 respirators.Results: We found that treatment in a climate chamber at 70 degrees C during 1 h with 75% humidity rate was adequate for enabling substantial decontamination of both respiratory viruses, oropharyngeal bacteria, and model animal coronaviuses, while maintaining a satisfying filtering capacity.Limitations: Further studies are now required to confirm the feasibility of the whole process during routine practice.Conclusion: Our findings provide compelling evidence for the recycling of pre-used surgical masks and N95/FFP2 respirators in case of imminent mass shortfall.

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