Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Frederique CheruyAgnès DucharneFrédéric HourdinIonela MusatÉtienne VignonGuillaume GastineauVladislav BastrikovN. VuichardBinta DialloJean-Louis DufresneJosefine GhattasJean-Yves GrandpeixAbderrahmane IdelkadiLidia MellulFabienne MaignanMénégoz MartinCatherine OttleP. PeylinJérôme ServonnatFuxing WangYanfeng Zhao
• Organismes : Laboratoire de Météorologie Dynamique (UMR 8539) Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols Laboratoire de Météorologie Dynamique (UMR 8539) Ecole Polytechnique Fédérale de Lausanne Océan et variabilité du climat Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539) Institut Pierre-Simon-Laplace Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Institut des Géosciences de l’Environnement Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modelling the Earth Response to Multiple Anthropogenic Interactions and Dynamics Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539)
• Publié dans Journal of Advances in Modeling Earth Systems le 25/10/2020

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Résumé : This work is motivated by the identification of the land-atmosphere interactions as one of the key sources of uncertainty in climate change simulations. It documents new developments in related processes, namely, boundary layer/convection/clouds parameterizations and land surface parameterization in the Earth System Model of the Institut Pierre Simon Laplace (IPSL). Simulations forced by prescribed oceanic conditions are produced with different combinations of atmospheric and land surface parameterizations. They are used to explore the sensitivity to the atmospheric physics and/or soil physics of • major biases in the near surface variables over continents, • the energy and moisture coupling established at the soil/atmosphere interface in not too wet (energy limited) and not too dry (moisture limited) soil moisture regions also known as transition or "hot-spot" regions, • the river runoff at the outlet of major rivers. The package implemented in the IPSL-Climate Model for the Phase 6 of the Coupled Models Intercomparison Project (CMIP6) allows us to reduce several biases in the surface albedo, the snow cover, and the continental surface air temperature in summer as well as in the temperature profile in the surface layer of the polar regions. The interactions between soil moisture and atmosphere in hotspot regions are in better agreement with the observations. Rainfall is also significantly improved in volume and seasonality in several major river basins leading to an overall improvement in river discharge. However, the lack of consideration of floodplains and human influences in the model, for example, dams and irrigation, impacts the realism of simulated discharge. Plain Language Summary Land surface-atmosphere interactions play an essential role in the climate system. They strongly modulate the regional climates and have impacts on the global scale for instance through freshwater release into the oceans. Climate hazards (heat waves, droughts) and their impacts on populations also strongly depend on interactions between land and atmosphere and on their evolution with climate change. Climate models are precious tools to investigate how the Earth climate behaves. The sixth phase of the Climate Model Intercomparison Project (CMIP6) provides important tools to measure the progress and address the remaining open questions regarding the continental climate modeling. The representation of the land-atmosphere coupled system by the IPSL-Climate Model involved in CMIP6 is thoroughly evaluated against observations and compared with simulations using the CMIP5 version. Several biases concerning the temperature over land and over the ice sheets and with the snow cover are significantly reduced. Numerous improvements were made developping advanced parameterizations and tuning of the radiation and of the turbulent mixing in the atmospheric model. The realism of the seasonal

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Fichiers liés : Cheruy_2020-IPSL-CM6_JAMES.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Jules MesnierYves CottinPierre CosteEmile FerrariFrançois SchieleGilles LemesleChristophe ThuaireDenis AngoulvantGuillaume CaylaClaire BouletiRomain Gallet de Saint AurinPascal GoubeThibault LhermusierJean-Guillaume DillingerFranck PaganelliAnis SaibFabrice PrunierGerald VanzettoOlivier DubreuilÉtienne PuymiratFranck BoccaraHélène EltchaninoffMarine CachanadoAlexandra RousseauElodie DrouetPhilippe Gabriel StegTabassome SimonNicolas Danchin
• Organismes : AP-HP - Hôpital Bichat - Claude Bernard [Paris] Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials Hôpital du Bocage Centre Hospitalier Universitaire de Bordeaux Hôpital Pasteur [Nice] Centre Hospitalier Régional Universitaire de Besançon Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 Institut Coeur Poumon [CHU Lille] Hôpital Louis Pasteur [Chartres] Hôpital Trousseau Centre Hospitalier Universitaire de Nîmes Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Henri Mondor Centre Hospitalier Sud Francilien Centre Hospitalier Universitaire de Toulouse Hôpital Lariboisière-Fernand-Widal [APHP] Service de cardiologie [Hôpital Nord - APHM] Groupe Hospitalier Intercommunal Le Raincy-Montfermeil MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire [CHU Grenoble] Service de cardiologie [centre hospitalier St-Joseph-et-St-Luc, Lyon] Hôpital Européen Georges Pompidou [APHP] CHU Saint-Antoine [AP-HP] Endothélium, valvulopathies et insuffisance cardiaque Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials CHU Saint-Antoine [AP-HP] Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials CHU Trousseau [Tours] CHU Saint-Antoine [AP-HP] Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials CHU Saint-Antoine [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials CHU Saint-Antoine [AP-HP] Hôpital Européen Georges Pompidou [APHP] Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials
• Publié dans The Lancet Public Health le 27/10/2020

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Résumé : Background: The COVID-19 pandemic has had a profound effect on general health care. We aimed to evaluate the effect of a nationwide lockdown in France on admissions to hospital for acute myocardial infarction, by patient characteristics and regional prevalence of the pandemic. Methods: In this registry study, we collected data from 21 centres participating in the ongoing French Cohort of Myocardial Infarction Evaluation (FRENCHIE) registry, which collects data from all patients admitted for ST segment elevation myocardial infarction (STEMI) or non-ST segment elevation myocardial infarction (NSTEMI) within 48 h of symptom onset. We analysed weekly hospital admissions over 8 weeks: the 4 weeks preceding the institution of the lockdown and the 4 weeks following lockdown. The primary outcome was the change in the number of hospital admissions for all types of acute myocardial infarction, NSTEMI, and STEMI between the 4 weeks before lockdown and the 4 weeks after lockdown. Comparisons between categorical variables were made using χ2 tests or Fisher's exact tests. Comparisons of continuous variables were made using Student's t tests or Mann-Whitney tests. Poisson regression was used to determine the significance of change in hospital admissions over the two periods, after verifying the absence of overdispersion. Age category, region, and type of acute myocardial infarction (STEMI or NSTEMI) were used as covariables. The FRENCHIE cohort is registered with ClinicalTrials.gov, NCT04050956. Findings: Between Feb 17 and April 12, 2020, 1167 patients were consecutively admitted within 48 h of acute myocardial infarction (583 with STEMI, 584 with NSTEMI) and were included in the study. Admissions for acute myocardial infarction decreased between the periods before and after lockdown was instituted, from 686 before to 481 after lockdown (30% decrease; incidence rate ratio 0·69 [95% CI 0·51-0·70]). Admissions for STEMI decreased from 331 to 252 (24%; 0·72 [0·62-0·85]), and admissions for NSTEMI decreased from 355 to 229 (35%; 0·64 [0·55-0·76]) following institution of the lockdown, with similar trends according to sex, risk factors, and regional prevalence of hospital admissions for COVID-19. Interpretation: A marked decrease in hospital admissions was observed following the lockdown, irrespective of patient characteristics and regional prevalence of COVID-19. Health authorities should be aware of these findings, in order to adapt their message if the COVID-19 pandemic persists or recurs, or in case of future major epidemics.

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Fichiers liés : 1-s2.0-S2468266720301882-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Pierre-Luc MouchelNizar SerhanRémy BétousThomas FargeEstelle SalandPhilippe de MedinaJean-Sébastien HoffmannJean-Emmanuel SarryM PoirotSandrine Silvente-PoirotChristian Récher
• Organismes : Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Équipe labellisée Ligue Nationale Contre le Cancer [Toulouse] Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole Affichem SAS [Toulouse] Communauté d'universités et établissements de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole Institut Universitaire du Cancer de Toulouse - Oncopole Service Hématologie - IUCT-Oncopole [CHU Toulouse]
• Publié dans Cancers le 21/10/2020

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Résumé : Dendrogenin A (DDA), a mammalian cholesterol metabolite with tumor suppressor properties, has recently been shown to exhibit strong anti-leukemic activity in acute myeloid leukemia (AML) cells by triggering lethal autophagy. Here, we demonstrated that DDA synergistically enhanced the toxicity of anthracyclines in AML cells but not in normal hematopoietic cells. Combination index of DDA treatment with either daunorubicin or idarubicin indicated a strong synergism in KG1a, KG1 and MV4-11 cell lines. This was confirmed in vivo using immunodeficient mice engrafted with MOLM-14 cells as well as in a panel of 20 genetically diverse AML patient samples. This effect was dependent on Liver X Receptor β, a major target of DDA. Furthermore, DDA plus idarubicin strongly increased p53BP1 expression and the number of DNA strand breaks in alkaline comet assays as compared to idarubicin alone, whereas DDA alone was non-genotoxic. Mechanistically, DDA induced JNK phosphorylation and the inhibition of AKT phosphorylation, thereby maximizing DNA damage induced by idarubicin and decreasing DNA repair. This activated autophagic cell death machinery in AML cells. Overall, this study shows that the combination of DDA and idarubicin is highly promising and supports clinical trials of dendrogenin A in AML patients.

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Fichiers liés : cancers-12-02933-v3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Anthony BoutonEmmanuelle VenninPhilippe Amiotte-SuchetChristophe ThomazoJean-Pierre SizunAurélien VirgoneEric C. GaucherPieter T. Visscher
• Organismes : Biogéosciences [UMR 6282] Biogéosciences [UMR 6282] Biogéosciences [UMR 6282] Biogéosciences [UMR 6282] Laboratoire Chrono-environnement (UMR 6249) Centre scientifique et Technique Jean Feger Centre scientifique et Technique Jean Feger Biogéosciences [UMR 6282] Departments of Marine Sciences & Geosciences
• Publié dans Basin Research le 28/10/2020

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Résumé : Most source‐to‐sink studies typically focus on the dynamics of clastic sediments and consider erosion, transport and deposition of sediment particles as the sole contributors. Although often neglected, dissolved solids produced by weathering processes contribute significantly in the sedimentary dynamics of basins, supporting chemical and/or biological precipitation. Calcium ions are usually a major dissolved constituent of water drained through the watershed and may facilitate the precipitation of calcium carbonate when supersaturating conditions are reached. The high mobility of Ca2+ ions may cause outflow from an open system and consequently loss. In contrast, in closed basins, all dissolved (i.e. non‐volatile) inputs converge at the lowest point of the basin. The endoreic Great Salt Lake basin constitutes an excellent natural laboratory to study the dynamics of calcium on a basin scale, from the erosion and transport through the watershed to the sink, including sedimentation in lake's waterbody. The current investigation focused on the Holocene epoch. Despite successive lake level fluctuations (amplitude around 10 m), the average water level seems to have not been affected by any significant long‐term change (i.e. no increasing or decreasing trend, but fairly stable across the Holocene). Weathering of calcium‐rich minerals in the watershed mobilizes Ca2+ ions that are transported by surface streams and subsurface flow to the Great Salt Lake (GSL). Monitoring data of these flows was corrected for recent anthropogenic activity (river management) and combined with direct precipitation (i.e. rain and snow) and atmospheric dust income into the lake, allowing estimating the amount of calcium delivered to the GSL. These values were then extrapolated through the Holocene period and compared to the estimated amount of calcium stored in GSL water column, porewater and sediments (using hydrochemical, mapping, coring and petrophysical estimates). The similar estimate of calcium delivered (4.88 Gt) and calcium stored (3.94 Gt) is consistent with the premise of the source‐to‐sink approach: a mass balance between eroded and transported compounds and the sinks. The amount of calcium deposited in the basin can therefore be predicted indirectly from the different inputs, which can be assessed with more confidence. When monitoring is unavailable (e.g. in the fossil record), the geodynamic context, the average lithology of the watershed and the bioclimatic classification of an endoreic basin are alternative properties that may be used to estimate the inputs. We show that this approach is sufficiently accurate to predict the amount of calcium captured in a basin and can be extended to the whole fossil record and inform on the storage of calcium.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Mingchao JiJean-Philippe ChampeauxPatrick Moretto-CapelleJulie RenoudLaurent PolizziStéphane FaureMartine SencePierre Cafarelli
• Organismes : Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité
• Publié dans Journal of Physics B: Atomic, Molecular and Optical Physics le 26/10/2020

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Résumé : Electronic emission of isolated Pyrene molecule induced by 50 to 125 keV protons has been investigated. The corresponding absolute double differential cross-sections (DDCS) have been measured at 35° from the incident proton beam axis. These complete measurements were compared to the simulations of emitted electrons spectra using a Semi-Classical Trajectory Monte-Carlo approach (SCTMC). The simulated SCTMC cross-sections show a reasonably good agreement with the measured ones.

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Fichiers liés : Pyrene-v2 (1).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Bernard GoichotV. RaverotMarc KleinLavinia Vija RacaruJuliette Abeillon-Du PayratOlivier LairezRemy LeroyAnne CailleuxPierre WolffLionel GroussinGeorges KaltenbachPhilippe Caron
• Organismes : Hôpitaux Universitaires de Strasbourg Hospices Civils de Lyon Integrated Physiology of the Brain Arousal Systems Service de Biochimie et Biologie Moléculaire Grand Est [HCL, Lyon] Centre Hospitalier Régional Universitaire de Nancy Service de Médecine Nucléaire - Rangueil [CHU Toulouse] Institut Universitaire du Cancer de Toulouse - Oncopole Hospices Civils de Lyon Service Cardiologie [CHU Toulouse] Clinique Mathilde [Rouen] Institut Cochin Hôpitaux Universitaires de Strasbourg Service Endocrinologie, maladies métaboliques et nutrition [CHU Toulouse]
• Publié dans Annales d'Endocrinologie = Annals of Endocrinology le 25/10/2020

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Résumé : The elderly population is classically defined by the World Health Organization (WHO) and in the international literature, including in endocrinology, as aged more than 65 years; “geriatrics” begins with 75 year-old patients with multiple pathology. The prevalence of loss of functional autonomy due to comorbidities increases sharply after 85 years of age. In the French population, life-expectancy is increasing by 3 months every year, and the over-65-year-old population is now 18% of the general population, and 9% in over-75-year-old subjects in France.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Anne Laure RoupieAlexis GuedonBenjamin TerrierConstance LahunaVincent JachietAlexis RégentHubert de BoyssonFabrice CarratJulie SeguierLouis TerriouMathilde VersiniViviane QueyrelMatthieu GrohYgal BenhamouFrancois MaurierEmmanuel LedoultLenaig Le ClechMaud d'AveniJulien RossignolJoris GallandLise WillemsNoemie Jourde ChichePierre PeterlinMarielle Roux-SauvatAnne ParcelierMatthieu WemeauMarc LambertCristina BeliznaXavier PuéchalLaure SwiaderRolande Cohen-ValensiValérie NocEmmanuel DaoSylvain ThepotGrégoire Martin de FrémontAline Tanguy-SchmidtAnne Marfaing KokaGuillaume BussoneCarole PhilipponnetAmadou KonateGuilhem CavaillePhilippe GuilpainJean-Sébastien AllainJonathan BronerÉric SolaryMarc RuivardBenoit de RenzisSélim CormNadia BaatiNicolas SchleinitzMatthieu PonsoyeAspasia Stamatoullas-BastardLionel AdèsAzeddine DellalAndrei TchirkovAchille AoubaPierre FenauxOlivier FainArsène Mékinian
• Organismes : Département d'hématologie [Gustave Roussy] Hématopoïèse normale et pathologique Dynamique moléculaire de la transformation hématopoïétique
• Publié dans Seminars in Arthritis and Rheumatism le 28/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Jean BousquetCezmi A AkdisMarek JutelClaus BachertLudger KlimekIoana AgacheIgnacio Javier Ansotegui-ZubeldiaAnna BedbrookSinthia Bosnic-AnticevichG Walter CanonicaTomás ChivatoAlvaro A. CruzWienczyslawa CzarlewskiStefano del GiaccoHui DuJoão Almeida FonsecaYadong GaoTari HaahtelaKarin Hoffmann-SommergruberJuan-Carlos IvancevichNikolaï KhaltaevEdward KnolP. KunaDesiree Larenas-LinnemannJ. MullolRobert NaclerioKen OhtaYoshitaka OkamotoLiam O’mahonyGabrielle OnoratoNikolaos G. PapadopoulosOliver PfaarBoleslaw SamolinskiJürgen SchwarzeSanna Toppila-SalmiMaria-Teresa VenturaArunas ValiulisArzu YorganciogluTorsten ZuberbierRuby PawankarSinthia Bosnic‐anticevichGiorgio Walter CanonicaKarin Hoffmann‐sommergruberJuan‐carlos IvancevichDesiree Larenas‐linnemannLiam O’mahonySanna Katriina Toppila-SalmiAkdis MubeccelAl‐ahmad MonaAlvarez Cuesta EmilioArshad HasanArtesani Maria CristinaAwad ZeinabBadr Eldin MostafaBarba SergioBarbara CristinaBateman EricBeghe BiancaBel ElisabethBergmann Larl‐christianBernstein DavidBjermer LeifBoner AttilioBonini SergioBosse IsabelleBouchard JacquesBoulet Louis‐philippeBraido FulvioBrightling ChristopherBuhl RolandBunu CarmenBush AndrewBusse WilliamCaballero‐fonseca FernanD. CaimmiCaimmi SilviaCamargos PauloCanonica WalterCardona VickyCarlsen Kai‐hakonCarr WarnerCasale ThomasCecchi LorenzoCepeda Mario AlfonsoChavannes NielsChkhartishvili EkaterineChristoff GeorgeChu DerekCingi CemalCiprandi GiorgioCirule IevaCorreia De Sousa JaimeCosta Dominguez del CarmenCoste AndréCox LindaCruz AlvaroCustovic AdnanDarsow Ulfde Blay FrédéricDeleanu DianaPascal DemolyDevillier PhilippeDidier AlainDjukanovic RatkoDo Ceu Teixeira MariaDokic DejanDubakiene RutaDurham StephenEklund PatrikEl‐gamal YehiaEmuzyte ReginaEsser‐von Bieren JuliaFiocchi AlessandroFokkens WytskeGaga MinaGálvez Romero José LuisGemicioglu BilunGenova SonyaGereda JoséGomez MaximilianoGotua MaiaGrisle InetaGuidacci MartaGuzman Maria AntonietaHejjaoui AdnanHossny ElhamHourihane JonathanHrubiško MartinHuerta Villalobos YunuenIaccarino GuidoIrani CarlaIspayeva ZhanatJares EdgardoJassem EwaJensen‐jarolim ErikaJohnston SebastianJoos GuyJung Ki‐suckJust JocelyneKaidashev IgorKalayci OmerKalyoncu FuatKardas PrzemyslawKarjalainen JussiKleine‐tebbe JorgKoppelman GerardKowalski MarekKuitunen MikaelKvedariene VioletaLatiff AmirLau SusanneLe LanLessa MarcusLevin MichaelLi JingLieberman PhilipLipworth BrianLodrup Carlsen KarinMahboub BassamMakela MikaMalling Hans‐jorgenMarshall GailenMartins PedroMasjedi MohammadMatta Juan‐joséMeço CemMelén ErikMeltzer EliMerk HansMichel Jean‐pierreMihaltan FlorinMiculinic NevenMilenkovic BranislavaMohammad YousserMolimard MathieuMorais‐almeida MarioMösges RalphMünter LarsMuraro AntonellaMustakov TihomirNakonechna AllaNamazova‐baranova LeylaNekam KristofNicod LaurentO’hehir RobynOkubo KimihiroOliver BrianPaggiaro Pier LuigiPali‐schöll IsabellaPanzner PetrPapadopoulos NilosPark Hae SimPawankar RubyPereira AnaPigearias BernardPitsios ConstantinosPlavec DavorPohl WolfgangPopov TodorPortejoie FabiennePotter PaulPoulsen LarsProkopakis EmmanuelRabe ClausRecto Marysia StellaRimmer JanetRizzo José AngeloRoberts GrahamRoche NicolasRomano AntoninoRosado‐pinto JoseRosario NelsonRosenwasser LannyRouadi PhilipRyan DermotSanchez‐borges MarioSastre‐dominguez JoaquinScadding GlenisSerrano ElieSiafakas NikolaosSimons EstelleSisul Juan‐carlosSolé DirceuSooronbaev TalantSoto‐martinez ManuelStellato CristianaStelmach RafaelStrandberg TimoSuppli Ulrik CharlotteThijs CarelTomazic Peter‐valentinTriggiani MassimoTsiligianni IoanaUrrutia Pereira MarilynValovirta Erkkavan Ganse Ericvan Hage MarianneVandenplas OlivierVidgren PetraWagenmann MartinWallace DanaWang De YunWaserman SusanWickman MagnusWilliams DennisYawn BarbaraYorgancioglu ArzuYusuf OsmanZernotti MarioZidarn Mihaela
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
• Publié dans Allergy le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Marija SmokvarskaCharbel FrancisMatthieu PlatreJean-Bernard FicheCarine AlconXavier DumontPhilippe NacryVincent BayleMarcelo NollmannChristophe MaurelYvon JaillaisAlexandre Martinière
• Organismes : Biochimie et Physiologie Moléculaire des Plantes Biochimie et Physiologie Moléculaire des Plantes Reproduction et développement des plantes Biochimie et Physiologie Moléculaire des Plantes Biochimie et Physiologie Moléculaire des Plantes Biochimie et Physiologie Moléculaire des Plantes Reproduction et développement des plantes Centre de Biochimie Structurale [Montpellier] Biochimie et Physiologie Moléculaire des Plantes Reproduction et développement des plantes Biochimie et Physiologie Moléculaire des Plantes
• Publié dans Current Biology le 31/10/2020

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Résumé : In the course of their growth and development, plants have to constantly perceive and react to their environment. This is achieved in cells by the coordination of complex combinatorial signaling networks. However, how signal integration and specificity are achieved in this context is unknown. With a focus on the hyperosmotic stimulus, we use live super-resolution light imaging methods to demonstrate that a Rho GTPase, Rho-of-Plant 6 (ROP6), forms stimuli-dependent nanodomains within the plasma membrane (PM). These nanodomains are necessary and sufficient to transduce production of reactive oxygen species (ROS) that act as secondary messengers and trigger several plant adaptive responses to osmotic constraints. Furthermore, osmotic signal triggers interaction between ROP6 and two NADPH oxidases that subsequently generate ROS. ROP6 nanoclustering is also needed for cell surface auxin signaling, but short-time auxin treatment does not induce ROS accumulation. We show that auxin-induced ROP6 nanodomains, unlike osmotically driven ROP6 clusters, do not recruit the NADPH oxidase, RBOHD. Together, our results suggest that Rho GTPase nano-partitioning at the PM ensures signal specificity downstream of independent stimuli.

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Fichiers liés : SmokvarskaM.-et al-PostPrint-CurBiol-2020.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2020
• Auteurs : Martin StienenChristian FreyschlagKarl SchallerTorstein MelingAmir Al-AminRafid Al-MahfoudhAymeric AmelotLisa ArvidssonAlkinoos AthanasiouCecilia AvellanLuc BauchetLuka BerilazicCiaran BolgerPierre BourdillonStathis BoviatsisOliver BozinovPedro BrancoWerner BraunsdorfJulian CahillHans ClusmannJens ConradDominik CordierNuno CristinoDjula DjilvesiJohnny DuerinckChloé DumotMehmet Akif DurakChristian EisenringGiuseppe EspositoPierre-Jacques FinielsTheofanis FlaskasChristian FreyschlagStéphane FuentesMario GanauIordanis GeorgiadisMiltiadis GeorgiopoulosDimitrios GiakoumettisNathalie GilisCatia GradilStefan GrauAndrey GrinGeorgios HadjigeorgiouMarc-Eric HalatschNils HechtMarkus HollingRosanda IlicLinda IkenNazaret Infante SantosTimothée JacquessonIbrahim JallohBojan JelacaStefanie KaestnerDarius KalasauskasAssylbek KaliyevJean-Charles KleiberJuergen KonczallaKarl KothbauerVojin KovacevicNenad KrajcinovicSandro KriegOlli-Pekka KämäräinenMirko LapcicChristophe LaprasJohan LjungqvistWilliam LoVincent LubranoMartin MajovskyRomain ManetFrancesco MarchiYerkin MedetovTorstein MelingIlaria MelloniAnthony MelotPatrick MertensStephen MetcalfeSvein MoerkveAlexa Ruiz MoraErion MusabelliuMohammad NaushahiAitimbetov NurzhanIbrahim OmerhodzicIddo PaldorJohan PalludVakis PapanastassiouVladimir PapicThanasis PaschalisMichael PayerSaskia PeerdemanPhilippe PeruzziJenny Pettersson SegerlindJussi PostiFrancois ProustLuca RegliJaako RinnePierre-Hugues RocheSaulius RockaRoman RotermundScott RutherfordTönu RätsepAndreas RüterIlkka SaarenpääMustafa SamanciMarko SamardzicNicolas SampronUlrika SandvikAlba ScerratiKarl SchallerMichel SchneiderDavid SchulGoksin SengulEmile SimonSaurabh SinhaOle SolheimGiorgio SpatolaSergey SpektorMartin StienenJimmy SundblomNikolaos SyrmosMario TeoSimon ThomsonNikolay TonchevLazar TosicWilliam VandertopChristian von der BrelieAleksic VukJames WalkdenChristopher WendelMohammed YaqoutMadina YusupovaGianluca Zollino
• Organismes : Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis
• Publié dans Acta Neurochirurgica le 25/10/2020

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Résumé : Abstract Background In a previous article ( 10.1007/s00701-019-03888-3 ), preliminary results of a survey, aiming to shed light on the number of surgical procedures performed and assisted during neurosurgery residency in Europe were reported. We here present the final results and extend the analyses. Methods Board-certified neurosurgeons of European Association of Neurosurgical Societies (EANS) member countries were asked to review their residency case logs and participate in a 31-question electronic survey (SurveyMonkey Inc., San Mateo, CA). The responses received between April 25, 2018, and April 25, 2020, were considered. We excluded responses that were incomplete, from non-EANS member countries, or from respondents that have not yet completed their residency. Results Of 430 responses, 168 were considered for analysis after checking in- and exclusion criteria. Survey responders had a mean age of 42.7 ± 8.8 years, and 88.8% were male. Responses mainly came from surgeons employed at university/teaching hospitals (85.1%) in Germany (22.0%), France (12.5%), the United Kingdom (UK; 8.3%), Switzerland (7.7%), and Greece (7.1%). Most responders graduated in the years between 2011 and 2019 (57.7%). Thirty-eight responders (22.6%) graduated before and 130 responders (77.4%) after the European WTD 2003/88/EC came into effect. The mean number of surgical procedures performed independently, supervised or assisted throughout residency was 540 (95% CI 424–657), 482 (95% CI 398–568), and 579 (95% CI 441–717), respectively. Detailed numbers for cranial, spinal, adult, and pediatric subgroups are presented in the article. There was an annual decrease of about 33 cases in total caseload between 1976 and 2019 (coeff. − 33, 95% CI − 62 to − 4, p = 0.025). Variables associated with lesser total caseload during residency were training abroad (1210 vs. 1747, p = 0.083) and female sex by trend (947 vs. 1671, p = 0.111), whereas case numbers were comparable across the EANS countries ( p = 0.443). Conclusion The final results of this survey largely confirm the previously reported numbers. They provide an opportunity for current trainees to compare their own case logs with. Again, we confirm a significant decline in surgical exposure during training between 1976 and 2019. In addition, the current analysis reveals that female sex and training abroad may be variables associated with lesser case numbers during residency.

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