Philippe JEAN-PIERRE

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• Type de publi. :
• Date de publi. : 19/09/2020
• Auteurs : Philippe FayemendyMarion VergonjeanneGéraldine LautretteN. CalmelHuguette SourisseauPierre-Marie PreuxPhilippe CouratierJean-Claude DesportPierre Jésus
• Organismes : Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale Neuroépidémiologie Tropicale Service de Neurologie [CHU Limoges] Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale

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Résumé : Rationale: In Amyotrophic lateral sclerosis (ALS), gastrostomy is indicated when the weight loss is over 10%, in case of repeated aspirations and if the meal time duration is over 45 min. The benefit of gastrostomy on survival in ALS is unclear and its placement is probably too late. The main works on the subject studied survival from diagnosis but not from indication of gastrostomy. The aims of our work were in ALS patients with indication of gastrostomy and who accepted or refused gastrostomy to study from the indication of gastrostomy to the last assessment or death i) the evolution of nutritional and neurological status and ii) the survival. Methods: ALS patients included started follow-up in the referral ALS centre in 2006 and were all dead at 31 december 2017. They had assessment of their neurological (onset form, ALS functional rating scale revised [ALSFRS-R]), nutritional (weight, weight loss, body mass index and body composition by bioelectrical impedancemetry analysis) and respiratory status (forced vital capacity, non-invasive ventilation [NIV]). Statistical analysis was done by using Mann-Whitney test, Chi2 tests, Kaplan-Meier with Log-rank and Cox model for multivariate survival analysis. Results were expressed as median (interquartile range). Results: One hundred and fifty-five patients with indication of gastrostomy were included, 68.4% had accepted the gastrostomy placement. The median delay diagnosis-gastrostomy indication and gastrostomy indication-last assessment were 5.1 months (2.3 – 12.5) and 8.7 months (4.2 – 12.3), respectively. Patient who accepted gastrostomy were less often male (42.5% vs. 63.3%, p= 0.016) and had more often bulbar onset (57.6% vs. 26.5%, p=0.0003). Nutritional status and body composition at indication and at last assessment were not significantly different in patients with or without gastrostomy. At last assessment, in patient with gastrostomy ALSFRS-R was lower (14.0 points [10.8 – 22.0] vs. 20.5 points [12.8 – 26.3], p=0.01). Since gastrostomy indication median survival was higher in patient who accepted gastrostomy (10.3 months [6.7 – 17.5] vs 7.9 month [4.2 – 10.5], p=0.01). Gastrostomy was negatively associated with the risk of death in univariate analysis (HR: 0.64, p=0.01), but not in multivariate analysis. In multivariate analysis, weight loss (-1%/month) and ALSFRS-R slope (-1point/month) during follow-up were positively associated with the risk of death (aHR: 1.62; p=0.0002 and aHR: 2.37; p<0.0001, respectively). An increased delay between gastrostomy indication and VNI placement (+1month) was negatively associated with the risk of death (aHR: 0.95; p=0.0003). Conclusion: In ALS patients with indication of gastrostomy and who accepted gastrostomy, survival seems higher. However, independently of the gastrostomy placement the factors positively associated with the risk of death were a more important alteration of nutrition status (weight loss) and of functional status (ALSFRS-R slope) between indication of gastrostomy and last assessment. It also seems important to consider the placement of NIV after indication of the gastrostomy and not the reverse. In this disease whose functional impairment and death are inevitable, nutritional support adapted to the patient's disorders and wishes remains essential.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/09/2020
• Auteurs : Ferréol SalomonCécile VittoriBrice NoirotElisa PleugerCarlo RosaIlaria MazziniPierre CarbonelHatem DjerbiPiero BellottiJean-Philippe Goiran
• Organismes : Laboratoire Image, Ville, Environnement Laboratoire Image, Ville, Environnement ARCHEORIENT - Environnements et sociétés de l'Orient ancien Environnement, Ville, Société ARCHEORIENT - Environnements et sociétés de l'Orient ancien Argiles, Géochimie et Environnements sédimentaires Istituto Italiano di Paleontologia Umana Consiglio Nazionale della Ricerche [Roma] Environnements et Paléoenvironnements OCéaniques Études et valorisations archéologiques Dipartimento di Scienze della Terra ARCHEORIENT - Environnements et sociétés de l'Orient ancien
• Publié dans Geomorphology le 25/10/2020

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Résumé : Located between the deltaic plain and the subaqueous delta, base level is one of the most important factors that affect depositional elements and the sedimentary architecture of river deltas. In this respect, its changes are essential to reconstruct delta evolution during the Holocene. In this paper, we study three cores drilled in the Tiber delta (Italy). Palaeoenvironmental analyses were performed and included new sedimentological data (laser grain size, loss-on-ignition, magnetic susceptibility), new data from bioindicators (ostracods and macrofauna), and 11 new radiocarbon dates. The three cores were analysed and replaced in a cross section between the Inner and Outer Tiber delta, i.e.,in the palaeolagoon and in the progradational delta plain. First, we have mapped the Holocene transgression and progradation of the Ostia area using palaeoenvironmental age-depth modelling techniques (PADMs). PADM charts help to interpret a stratigraphic succession in a river delta. They contribute to the understanding of the links between depositional environments, sedimentation rate, and sea level rise and to reconstruct coastline trajectories. More precisely, they contribute to the interpretation of the consequences of the sea level jumps dated to the 9000–8000 cal. BP period on coastal environments and help to identify progradational phases (around 4 k, and from 2.8 to 2.6 k cal. BP). Second, we identify indirect (freshwater bioindicators) and direct (bedload-derived facies) evidence of fluvial activity in the studied cross section. The studied deep cores indicate that at least one palaeochannel of the Tiber River was already flowing in the middle/southern part of the delta from 4 k cal. BP. Finally, a first map of the lateral mobility of the palaeochannels of the Tiber River is proposed for the last 6 k cal. BP using the new data and a synthesis of all the data available at the scale of the delta.

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Fichiers liés : S0169555X20301999.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/09/2020
• Auteurs : Annie WongSusan WijffelsStephen RiserSylvie PouliquenShigeki HosodaDean RoemmichJohn GilsonGregory JohnsonKim MartiniDavid MurphyMegan ScanderbegT. BhaskarJustin BuckFrédéric MerceurThierry CarvalGuillaume MazeCécile CabanesXavier AndreNoé PoffaIgor YashayaevPaul BarkerStéphanie GuinehutMathieu BelbéochMark IgnaszewskiMolly O'Neil BaringerClaudia SchmidJohn LymanKristene MctaggartSarah PurkeyNathalie ZilbermanMatthew AlkireDana SwiftW. Brechner OwensSteven JayneCora HershPelle RobbinsDeb West-MackFrank BahrSachiko YoshidaPhilip SuttonRomain CancouëtChristine CoatanoanDelphine DobblerAndrea Garcia JuanJerôme GourrionNicolas KolodziejczykVincent BernardBernard BourlèsHervé ClaustreFabrizio d'OrtenzioSerge Le RestePierre-Yves Le TraonJean-Philippe RannouCarole Saout-GritSabrina SpeichVirginie ThierryNathalie VerbruggeIngrid Angel-BenavidesBirgit KleinGiulio NotarstefanoPierre-Marie PoulainPedro Vélez-BelchíToshio SugaKentaro AndoNaoto IwasaskaTaiyo KobayashiShuhei MasudaEitarou OkaKanako SatoTomoaki NakamuraKatsunari SatoYasushi TakatsukiTakashi YoshidaRebecca CowleyJenny LovellPeter OkeEsmee van WijkFiona CarseMatthew DonnellyW. John GouldKatie GowersBrian KingStephen LochMary MowatJon TurtonE. Pattabhi Rama RaoM. RavichandranHoward FreelandIsabelle GabouryDenis GilbertBlair GreenanMathieu OuelletTetjana RossAnh TranMingmei DongZenghong LiuJianping XuKiryong KangHyeongjun JoSung-Dae KimHyuk-Min Park
• Organismes : University of Washington [Seattle] Woods Hole Oceanographic Institution University of Washington [Seattle] Département Infrastructures de Recherche et Systèmes d'Information Japan Agency for Marine-Earth Science and Technology Scripps Institution of Oceanography Scripps Institution of Oceanography NOAA Pacific Marine Environmental Laboratory [Seattle] Scripps Institution of Oceanography Indian National Centre for Ocean Information Services British Oceanographic Data Centre Département Infrastructures de Recherche et Systèmes d'Information Département Infrastructures de Recherche et Systèmes d'Information Laboratoire d'Océanographie Physique et Spatiale Laboratoire d'Océanographie Physique et Spatiale Unité Recherches et Développements Technologiques Département Infrastructures de Recherche et Systèmes d'Information Institut océanographique Bedford - Bedford Oceanographic Institute [Dartmouth, Canada] University of New South Wales [Sydney] Collecte Localisation Satellites OceanOPS Fleet Numerical Meteorology and Oceanography Center NOAA Atlantic Oceanographic and Meteorological Laboratory NOAA Atlantic Oceanographic and Meteorological Laboratory NOAA Pacific Marine Environmental Laboratory [Seattle] Joint Institute for Marine and Atmospheric Research NOAA Pacific Marine Environmental Laboratory [Seattle] Scripps Institution of Oceanography Scripps Institution of Oceanography University of Washington [Seattle] Woods Hole Oceanographic Institution Woods Hole Oceanographic Institution Woods Hole Oceanographic Institution Woods Hole Oceanographic Institution Woods Hole Oceanographic Institution Woods Hole Oceanographic Institution Woods Hole Oceanographic Institution Woods Hole Oceanographic Institution National Institute of Water and Atmospheric Research [Wellington] EuroArgo ERIC Département Infrastructures de Recherche et Systèmes d'Information Département Infrastructures de Recherche et Systèmes d'Information EuroArgo ERIC Société Coopérative OceanScope Laboratoire d'Océanographie Physique et Spatiale Département Infrastructures de Recherche et Systèmes d'Information Instrumentation, Moyens analytiques, Observatoires en Géophysique et Océanographie Laboratoire d'océanographie de Villefranche Laboratoire d'océanographie de Villefranche Unité Recherches et Développements Technologiques Mercator Océan International Atlantide-Altran Ouest Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire d'Océanographie Physique et Spatiale Collecte Localisation Satellites Federal Maritime and Hydrographic Agency [Hamburg] Federal Maritime and Hydrographic Agency [Hamburg] Istituto Nazionale di Oceanografia e di Geofisica Sperimentale = National Institute of Oceanography and Experimental Geophysics Instituto Espagňol de Oceanografia Tohoku University [Sendai] Japan Agency for Marine-Earth Science and Technology Tokyo University of Marine Science and Technology Japan Agency for Marine-Earth Science and Technology Japan Agency for Marine-Earth Science and Technology The University of Tokyo Japan Agency for Marine-Earth Science and Technology Japan Meteorological Agency Japan Meteorological Agency Japan Meteorological Agency Japan Meteorological Agency CSIRO Marine and Atmosphere Research [Hobart] CSIRO Marine and Atmosphere Research [Hobart] CSIRO Marine and Atmosphere Research [Hobart] CSIRO Marine and Atmosphere Research [Hobart] University of Tasmania [Hobart] United Kingdom Met Office [Exeter] British Oceanographic Data Centre National Oceanography Centre [Southampton] British Oceanographic Data Centre National Oceanography Centre [Southampton] British Oceanographic Data Centre British Geological Survey United Kingdom Met Office [Exeter] Indian National Centre for Ocean Information Services National Centre for Polar and Ocean Research Institute of Ocean Sciences [Sidney] Fisheries and Oceans Canada = Pêches et Océans Canada [Ottawa] Institut Maurice-Lamontagne Laboratoire d'Océanographie Physique et Spatiale Fisheries and Oceans Canada = Pêches et Océans Canada [Ottawa] Institute of Ocean Sciences [Sidney] Fisheries and Oceans Canada = Pêches et Océans Canada [Ottawa] National Marine Data and Information Service State Oceanic Administration State Oceanic Administration National Institute of Meteorological Sciences National Institute of Meteorological Sciences Korea Institute of Ocean Science and Technology Korea Institute of Ocean Science and Technology
• Publié dans Frontiers in Marine Science le 29/10/2020

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Fichiers liés : fmars-07-00700.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/09/2020
• Auteurs : Minayégninrin KonéEmmanuel Kouassi N’gouanDramane KabaMathurin KoffiLingué KouakouLouis N’driCyrille Mambo KouaméValentin Kouassi NananGossé Apollinaire TapéBamoro CoulibalyFabrice CourtinAhouty Ahouty BernardinVincent DjohanBruno BuchetonPhilippe SolanoPhilippe BüscherVeerle LejonVincent Jamonneau
• Organismes : Institut Pierre Richet [Bouaké, Côte d'Ivoire] Université Jean Lorougnon Guédé Institut Pierre Richet [Bouaké, Côte d'Ivoire] Université Jean Lorougnon Guédé Institut Pierre Richet [Bouaké, Côte d'Ivoire] Institut Pierre Richet [Bouaké, Côte d'Ivoire] Institut Pierre Richet [Bouaké, Côte d'Ivoire] Centre international de recherche-développement sur l'élevage en zone sub-humide Institut de Recherche pour le Développement Institut Pierre Richet [Bouaké, Côte d'Ivoire] Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides Université de Montpellier Université Jean Lorougnon Guédé Institut Pierre Richet [Bouaké, Côte d'Ivoire] Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides Université de Montpellier Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides Université de Montpellier Institute of Tropical Medicine [Antwerp] Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides Université de Montpellier Institut Pierre Richet [Bouaké, Côte d'Ivoire] Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides Université de Montpellier
• Publié dans PLoS Neglected Tropical Diseases le 23/10/2020

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Résumé : BackgroundSignificant efforts to control human African trypanosomiasis (HAT) over the two past decades have resulted in drastic decrease of its prevalence in Côte d’Ivoire. In this context, passive surveillance, integrated in the national health system and based on clinical suspicion, was reinforced. We describe here the health-seeking pathway of a girl who was the first HAT patient diagnosed through this strategy in August 2017.MethodsAfter definitive diagnosis of this patient, epidemiological investigations were carried out into the clinical evolution and the health and therapeutic itinerary of the patient before diagnosis.ResultsAt the time of diagnosis, the patient was positive in both serological and molecular tests and trypanosomes were detected in blood and cerebrospinal fluid. She suffered from important neurological disorders. The first disease symptoms had appeared three years earlier, and the patient had visited several public and private peripheral health care centres and hospitals in different cities. The failure to diagnose HAT for such a long time caused significant health deterioration and was an important financial burden for the family.ConclusionThis description illustrates the complexity of detecting the last HAT cases due to complex diagnosis and the progressive disinterest and unawareness by both health professionals and the population. It confirms the need of implementing passive surveillance in combination with continued sensitization and health staff training.

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Fichiers liés : pntd.0008588.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 14/09/2020
• Auteurs : Marie Ange Ngo BiengManuel BoissièreEmilien DubiezBruno HéraultPhilippe GuizolJean-Pierre MoralesJean-Marc RodaRoger VillalobosPlinio SistBryan Finegan
• Organismes : Forêts et Sociétés Forêts et Sociétés Forêts et Sociétés Forêts et Sociétés Forêts et Sociétés Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center Forêts et Sociétés Forêts et Sociétés Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center

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Résumé : In this talk, we will address issues related to the potential of tropical secondary and degraded forests (SDFs) as sustainable and complementary alternatives for wood production, from case studies in Central American countries. We will also discuss the potential of wood production in SDFs as an effective NBS for the climate crisis, i.e. associated to effective mitigation in the future. Tropical secondary (1) and degraded (2) forests are disturbed forest areas, growing in formerly deforested areas (1) or which have suffered from unsustained human activities, such as unplanned and repetitive logging or fire (2). They have consequently lost their capacity to provide a high level of goods and services. SDFs are important worldwide as they account for swathes of forest landscapes and are invaluable forest ecosystems related to biodiversity recovery, carbon storage, but also a diversity of other forest ecosystem services. However, they are fragile and endangered forest ecosystems, as they are located in highly dynamic pressured landscapes and are susceptible to catastrophic events. Without appropriate silvicultural management designed to increase their economic value, they may well be cleared for more economically productive activities. Moreover, the increasing demand for tropical timber in recent decades and in the near future may worsen the pressure on these fragile ecosystems. We suggest that active restoration implemented towards wood production in SDFs may amount to a sustainable and complementary alternative for wood production in the future. Wood production is definitely an opportunity for SDF conservation in the context of the increase in wood demand, while limiting pressure for wood demand on the remaining natural forests. Moreover, SDF maintenance and restoration through secondary forest dynamics contribute significantly to the maintenance of crucial ecosystems services in the context of the climate crisis. Following the CATIE project on secondary forest dynamics and valuation in Central American countries (IKI Funding program 2017–2020), we are setting up with FTA support (2020), work on the assessment and the improvement of wood production potential from secondary forests through analysis of data from national forest inventories in Central American countries. During the FTA science conference 2020, we will present the first results of this work. We will discuss the limitations and opportunities associated with wood production in tropical SDFs nowadays in the global context, but also the mitigation potential associated to wood production in these SDFs.

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Fichiers liés : ID597895.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 10/09/2020
• Auteurs : Loria ZalmaïPierre-Julien ViaillySabeha BiichleMeyling CheokLou SoretFanny Angelot-DelettreTony PetrellaMarie-Agnès Collonge-RameEstelle SeillesSandrine GeffroyEric DeconinckEtienne DaguindauSabrina BouyerElodie DindinaudVictor BauninMagali Le Garff-TavernierDamien Roos-WeilOrianne Wagner‐ballonVéronique SalaunJean FeuillardSophie BrunBernard DrenouCaroline Mayeur-RoussePatricia OkambaVéronique DorvauxMichel TichionniJohann RoseMarie-Thérèse RubioMarie Christine JacobVictoria RaggueneauClaude PreudhommePhilippe SaasChristophe FerrandOlivier AdoteviChristophe RoumierFabrice JardinFrancine Garnache-OttouFlorian Renosi
• Organismes : Hôpital Cochin [AP-HP] Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Institut pour la recherche sur le cancer de Lille [Lille] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Université de Montréal Centre Hospitalier Régional Universitaire de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Institut pour la recherche sur le cancer de Lille [Lille] Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Régional Universitaire de Besançon Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CH La Rochelle CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Hôpital Henri Mondor CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Limoges Hôpital Universitaire Carémeau [Nîmes] Groupe Hospitalier de Territoire Haute Alsace Centre Hospitalier Universitaire [Strasbourg] Centre hospitalier régional de Metz-Thionville Centre hospitalier régional de Metz-Thionville Hôpital Pasteur [Nice] Centre Hospitalier Le Mans (CH Le Mans) Service d'Hématologie [CHRU Nancy] Ingénierie Moléculaire et Physiopathologie Articulaire Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier de Versailles André Mignot Institut pour la recherche sur le cancer de Lille [Lille] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Institut pour la recherche sur le cancer de Lille [Lille] Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
• Publié dans Haematologica le 30/10/2020

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Résumé : Neoplasms involving plasmacytoid Dendritic Cells (pDCs) include Blastic pDC Neoplasms (BPDCN) and other pDC proliferations, where pDCs are associated with myeloid malignancies: most frequently Chronic MyeloMonocytic Leukemia (CMML) but also Acute Myeloid Leukemia (AML), hereafter named pDC-AML. We aimed to determine the reactive or neoplastic origin of pDCs in pDC-AML, and their link with the CD34+ blasts, monocytes or conventional DCs (cDCs) associated in the same sample, by phenotypic and molecular analyses (targeted NGS, 70 genes). We compared 15 pDC-AML at diagnosis with 21 BPDCN and 11 normal pDCs from healthy donors. CD45low CD34+ blasts were found in all cases (10-80% of medullar cells), associated with pDCs (4-36%), monocytes in 14 cases (1-10%) and cDCs (2 cases, 4.8-19%). pDCs in pDC-AML harbor a clearly different phenotype from BPDCN: CD4+ CD56- in 100% of cases, most frequently CD303+, CD304+ and CD34+; lower expression of cTCL1 and CD123 with isolated lymphoid markers (CD22/CD7/CD5) in some cases, suggesting a pre-pDC stage. In all cases, pDCs, monocytes and cDC are neoplastic since they harbor the same mutations as CD34+ blasts. RUNX1 is the most commonly mutated gene: detected in all AML with minimal differentiation (M0-AML) but not in the other cases. Despite low number of cases, the systematic association between M0-AML, RUNX1 mutations and an excess of pDC is puzzling. Further evaluation in a larger cohort is required to confirm RUNX1 mutations in pDC-AML with minimal differentiation and to investigate whether it represents a proliferation of blasts with macrophage and DC progenitor potential.

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Fichiers liés : 10047-Article Text-73339-2-10-20211126.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 10/09/2020
• Auteurs : Sabine KayserRichard SchlenkDelphine LebonMartin CarreKatharina GötzeFriedrich StölzelAna BerceanuKerstin Schäfer-EckartPierre PeterlinYosr HicheriRamy RahmeEmmanuel RaffouxFatiha ChermatStefan KrauseWalter AulitzkySophie RigaudeauRichard NoppeneyCéline BerthonMartin GörnerEdgar JostPhilippe CarassouUlrich KellerCorentin OrvainThorsten BraunColombe SaillardAli ArarVolker KunzmannMathieu WemeauMaike de WitDirk NiemannCaroline BonmatiCarsten SchwänenJulie AbrahamAhmad AljijakliStephanie HaiatAlwin KrämerAlbrecht ReichleMartina GnadlerChristophe WillekensKarsten SpiekermannWolfgang HiddemannCarsten Müller-TidowChristian ThiedeChristoph RölligHubert ServeMartin BornhäuserClaudia BaldusEva LengfelderPierre FenauxUwe PlatzbeckerLionel Adès
• Organismes : German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] Heidelberg University Hospital [Heidelberg] CHU Amiens-Picardie Centre Hospitalier Universitaire [CHU Grenoble] Technische Universität Munchen = Technical University Munich = Université Technique de Munich University Hospital Carl Gustav Carus [Dresden, Germany] Hôpital Jean Minjoz [Besançon] Klinikum Nürnberg Nord Hôtel-Dieu de Nantes Hôpital Saint Eloi [CHU Montpellier] Hopital Saint-Louis [AP-HP] Université Paris Diderot - Paris 7 Hopital Saint-Louis [AP-HP] Université Paris Diderot - Paris 7 Hopital Saint-Louis [AP-HP] Université Paris Diderot - Paris 7 University Hospital Erlangen = Uniklinikum Erlangen Robert Bosch Gmbh [Schwieberdingen] Centre Hospitalier de Versailles André Mignot University Hospital Essen Hôpital Claude Huriez [Lille] Klinikum Bielefeld [Bielefeld, Germany] Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] Centre hospitalier régional de Metz-Thionville Charité - UniversitätsMedizin = Berlin University Medicine Innate Immunity and Immunotherapy Centre Hospitalier Universitaire d'Angers Fédérations hospitalo-universitaires Grand Ouest Acute Leukemia [Angers] Hôpital Avicenne [AP-HP] Université Paris Cité Institut Paoli-Calmettes Centre Hospitalier Regional d'Orléans University Hospital of Würzburg Hôpital Provo Vivantes Klinikum Neukölln [Berlin, Germany] Gemeinschaftsklinikum Mittelrhein gGmbH [Koblenz, Germany] Centre Hospitalier Régional Universitaire de Nancy Ortenau Klinikum Offenburg-Kehl [Offenburg, Germany] Hôpital Dupuytren [CHU Limoges] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre Hospitalier Sud Francilien Universität Heidelberg [Heidelberg] = Heidelberg University University Hospital Regensburg St Vincentius Hospital Institut Gustave Roussy Dynamique moléculaire de la transformation hématopoïétique Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München UniversitätsKlinikum Heidelberg Technische Universität Dresden = Dresden University of Technology Technische Universität Dresden = Dresden University of Technology Universitätsklinikum Frankfurt am Main [Germany] Technische Universität Dresden = Dresden University of Technology Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel University of Mannheim = Universität Mannheim Hopital Saint-Louis [AP-HP] Université Paris Diderot - Paris 7 University Hospital Leipzig = Universitätsklinikum Leipzig Hopital Saint-Louis [AP-HP] Université Paris Diderot - Paris 7
• Publié dans Haematologica le 30/10/2020

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Résumé : The aim of this study was to characterize a large series of 154 patients with acute promyelocytic leukemia (APL; median age, 53 years; range, 18-90 years) and evaluate real-life outcome after up-front treatment with arsenic trioxide (ATO) and alltrans retinoic acid (ATRA). All patients were included in the prospective NAPOLEON registry (NCT02192619) between 2013 and 2019. APL was de novo in 91% (n=140) and therapy-related in 9% (n=14); 13% (n=20) were older than 70 years. At diagnosis bleeding/hemorrhage was present in 38% and thrombosis in 3%. Complete remission was achieved in 152 patients (99%), whereas two patients (1%) experienced induction death within 18 days after start of therapy. With a median follow-up of 1.99 years (95%-CI, 1.61-2.30 years) 1-year and 2-years overall survival (OS) rates were 97% (95%-CI, 94-100%) and 95% (95%-CI, 91-99%), respectively. Age above 70 years was associated with a significantly shorter OS (P<0.001) as compared to younger patients. So far no relapses were observed. Six patients (4%) died in CR after in median 0.95 years after diagnosis (range, 0.18-2.38 years). Our data confirm the efficiency and durability of ATO/ATRA in the primary management of adult low-/ intermediate-risk APL patients in the real life setting, irrespective of age.

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Fichiers liés : 10285-Article Text-75588-2-10-20211126.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/09/2020
• Auteurs : Florian BaillyAlain CantagrelPhilippe BertinSerge PerrotThierry ThomasThibaud LansamanLaurent GrangeDaniel WendlingCalogera DovicoAnne-Priscille Trouvin
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique Université Toulouse III - Paul Sabatier Hôpital Dupuytren [CHU Limoges] Centre d'Evaluation et de traitement de la douleur, AP-HP, Hôpital Cochin Physiopathologie et Pharmacologie Clinique de la Douleur Service de Rhumatologie [CHU Saint-Etienne] Service de médecine physique et réadaptation [CHU Raymond-Poincaré] Groupe de Recherche et d'Etude du Processus Inflammatoire Centre Hospitalier Universitaire [CHU Grenoble] Service de Rhumatologie CH Belfort-Montbéliard Centre d'Evaluation et de traitement de la douleur, AP-HP, Hôpital Cochin
• Publié dans RMD Open : Rheumatic & Musculoskeletal Diseases le 21/10/2020

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Résumé : Pain in rheumatic diseases is primarily due to mechanical or inflammatory mechanism, but neuropathic pain (NP) component is also occurring in many conditions and is probably underdiagnosed. The purpose of this article is to provide an overview of prevalence, pathophysiological and currently available treatment of NP in rheumatic diseases. When associated with clinical evaluation assessing neurological clinical signs and neuroanatomical distribution, Douleur Neuropathique 4 Questions, painDETECT, Leeds assessment of neuropathic symptoms and signs and Neuropathic Pain Questionnaire can detect NP component. Inflammatory or connective diseases, osteoarthritis, back pain or persistent pain after surgery are aetiologies that all may have a neuropathic component. Unlike nociceptive pain, NP does not respond to usual analgesics such as paracetamol and non-steroidal anti-inflammatory drugs. Entrapment neuropathy, peripheral neuropathy or smallfibre neuropathy are different aetiologies that can lead to NP. A part of the pain labelled neuropathic is rather nociplastic, secondary to a central sensitisation mechanism. Identifying the right component of pain (nociceptive vs neuropathic or nociplastic) could help to better manage pain in rheumatic diseases with pharmacological and nonpharmacological treatments.

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Fichiers liés : e001326.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/09/2020
• Auteurs : Jay Ram LamichhaneJean-Noël AubertotLuc ChampolivierPhilippe DebaekePierre Maury
• Organismes : AGroécologie, Innovations, teRritoires AGroécologie, Innovations, teRritoires Terres Inovia AGroécologie, Innovations, teRritoires École nationale supérieure agronomique de Toulouse
• Publié dans Frontiers in Plant Science le 24/10/2020

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Résumé : Soybean emergence and yield may be affected by many factors. A better understanding of the cultivar x sowing date x environment interactions could shed light into the competitiveness of soybean with other crops, notably, to help manage major biotic and abiotic factors that limit soybean production. We conducted a 2-year field experiments to measure emergence dynamics and final rates of three soybean cultivars from different maturity groups, with early and conventional sowing dates and across three locations. We also measured germination parameter values of the three soybean cultivars from different maturity groups under controlled experiments to parametrize the SIMPLE crop emergence model. This allowed us to assess the prediction quality of the model for emergence rates and to perform simulations. Final emergence rates under field conditions ranged from 62% to 92% and from 51% to 94% for early and conventional sowing, respectively. The model finely predicted emergence courses and final rates (root mean square error of prediction (RMSEP), efficiency (EF), and mean deviation (MD) ranging between 2% to 18%, 0.46% to 0.99%, and −10% to 15%, respectively) across a wide range of the sowing conditions tested. Differences in the final emergence rates were found, not only among cultivars but also among locations for the same cultivar, although no clear trend or consistent ranking was found in this regard. Modeling suggests that seedling mortality rates were dependent on the soil type with up to 35% and 14% of mortality in the silty loam soil, due to a soil surface crust and soil aggregates, respectively. Non-germination was the least important cause of seedling mortality in all soil types (up to 3% of emergence losses), while no seedling mortality due to drought was observed. The average grain yield ranged from 3.1 to 4.0 t ha −1 , and it was significantly affected by the irrigation regime (p < 0.001) and year (p < 0.001) but not by locations, sowing date or cultivars. We conclude that early sowing is unlikely to affect soybean emergence in

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Fichiers liés : Lamichhane_etal2020_Frontiers.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/09/2020
• Auteurs : Pierre BauvinClaire DelacôteGuillaume LassaillyLine Carolle Ntandja WandjiViviane GnemmiFlavien DautrecqueAlexandre LouvetRobert CaiazzoVioleta RaverdyEmmanuelle LeteurtreFrançois PattouSylvie Deuffic-BurbanPhilippe Mathurin
• Organismes : Institute for Translational Research in Inflammation - U 1286 Institute for Translational Research in Inflammation - U 1286 Institute for Translational Research in Inflammation - U 1286 Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Lille Neurosciences & Cognition - U 1172 Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Institute for Translational Research in Inflammation - U 1286 Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Recherche translationnelle sur le diabète - U 1190 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Recherche translationnelle sur le diabète - U 1190 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Lille Neurosciences & Cognition - U 1172 Alzheimer & Tauopathies [JPArc] Recherche translationnelle sur le diabète - U 1190 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institute for Translational Research in Inflammation - U 1286 Infection, Anti-microbiens, Modélisation, Evolution Institute for Translational Research in Inflammation - U 1286 Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
• Publié dans Liver International le 25/10/2020

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Résumé : Background & Aims Severely obese patients are a growing population at risk of non-alcoholic fatty liver disease (NAFLD). Considering the increasing burden, a predictive tool of NAFLD progression would be of interest. Our objective was to provide a tool allowing general practitioners to identify and refer the patients most at risk, and specialists to estimate disease progression and adapt the therapeutic strategy. Methods This predictive tool is based on a Markov model simulating steatosis, fibrosis and non-alcoholic steatohepatitis (NASH) evolution. This model was developped from data of 1801 severely obese, bariatric surgery candidates, with histological assessment, integrating duration of exposure to risk factors. It is then able to predict current disease severity in the absence of assessment, and future cirrhosis risk based on current stage. Results The model quantifies the impact of sex, body-mass index at 20, diabetes, age of overweight onset, on progression. For example, for 40-year-old severely obese patients seen by the general practitioners: (a) non-diabetic woman overweight at 20, and (b) diabetic man overweight at 10, without disease assessment, the model predicts their current risk to have NASH or F3-F4: for (a) 5.7% and 0.6%, for (b) 16.1% and 10.0% respectively. If those patients have been diagnosed F2 by the specialist, the model predicts the 5-year cirrhosis risk: 1.8% in the absence of NASH and 6.0% in its presence for (a), 10.3% and 26.7% respectively, for (b). Conclusions This model provides a decision-making tool to predict the risk of liver disease that could help manage severely obese patients.

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Fichiers liés : Manuscript_1308_unmarked_R2.pdf

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