Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Anne-Marie RuppertMichèle Beau-FallerDidier DebieuvreL'Houcine OuafikVirginie WesteelIsabelle RouquetteJulien MazièresPierre-Paul BringuierIsabelle MonnetFabienne EscandeCharles RicordelJean-Philippe MerlioHenri JanicotAntoinette LemoinePascal FoucherMichel PoudenxFranck MorinAlexandra LanglaisPierre-Jean SouquetFabrice BarlésiMarie Wislez
• Organismes : Groupe de recherche clinique Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules CHU Tenon [AP-HP] Hôpitaux Universitaires de Strasbourg Interface de Recherche Fondamentale et Appliquée en Cancérologie Nanomédecine Régénérative Groupe hospitalier de la région de Mulhouse Sud-Alsace Institut de neurophysiopathologie Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM] Centre Hospitalier Régional Universitaire de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Institut Universitaire du Cancer de Toulouse - Oncopole Service Pneumologie-Allergologie [CHU Toulouse] Groupement Hospitalier Lyon-Est Centre Hospitalier Intercommunal de Créteil Institut de Biochimie et Biologie Moléculaire [CHRU Lille] Oncogenesis, Stress, Signaling Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] INSERM U1053, Université Bordeaux, Bordeaux, France. CHU Clermont-Ferrand INSERM UMR S1193 Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Intergroupe Francophone de Cancérologie Thoracique [Paris] Intergroupe Francophone de Cancérologie Thoracique [Paris] Service de pneumologie [Centre Hospitalier Lyon Sud - HCL] Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM] Service de pneumologie [CHU Cochin] Centre de Recherche des Cordeliers
• Publié dans JTO Clinical and Research Reports le 07/10/2021

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Résumé : Introduction - Methods - In the Biomarkers France study, 4894 mutations (26.2%) were detected in 4634 patients from the 17,664 enrolled patients with NSCLC. Survival and treatment data on noncurative stage III to IV NSCLC were available for 901 patients. First- and second-line treatment effects on progression-free survival and overall survival were analyzed according to the mutations subtype. Results - Over 95% of patients with mutation were smokers or former smokers who were white (99.5%), presenting with adenocarcinoma (82.5%). The most common mutation subtype was G12C (374 patients; 41.5%), followed by G12V (168; 18.6%), G12D (131; 14.5%), G12A (62; 6.9%), G13C (45; 5.0%), G13D (31; 3.4%), and others (10; 1%). Approximately 21% of patients had transition mutation and 68.2% had a transversion mutation. G12D and transition mutations were predominant in never-smokers. The median overall survival for patients with -mutated NSCLC was 8.1 months (95% confidence interval [CI]: 7.5-9.5), without any differences according to the different subtypes mutations. The median progression-free survival was 4.6 months (95% CI: 4.2-5.1) for first-line treatment and 4.8 months (95% CI: 4.3-6.8) for second-line treatment, without any differences according to the different subtypes mutations. Conclusions

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Fichiers liés : PIIS2666364320300576.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Pauline MourlanettePierre BiverPhilippe RenardBenoit NoetingerGuillaume CaumonYassine Alexandre Perrier
• Organismes : Centre scientifique et Technique Jean Feger Université de Neuchâtel = University of Neuchatel Sorbonne Université Centre scientifique et Technique Jean Feger Université de Neuchâtel = University of Neuchatel IFP Energies nouvelles GeoRessources Ecole Nationale Supérieure de Géologie Ecole Nationale Supérieure de Géologie
• Publié dans Advances in Water Resources le 26/10/2020

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Résumé : Uncertainties related to permeability heterogeneity can be estimated using geostatistical simulation methods. Usually, these methods are applied on regular grids with cells of constant size, whereas unstructured grids are more flexible to honor geological structures and offer local refinements for fluid-flow simulations. However, cells of different sizes require to account for the support dependency of permeability statistics (support effect). This paper presents a novel workflow based on the power averaging technique. The averaging exponent ω is estimated using a response surface calibrated from numerical upscaling experiments. Using spectral turning bands, permeability is simulated on points in each unstructured cell, and later averaged with a local value of ω that depends on the cell size and shape. The method is illustrated on a synthetic case. The simulation of a tracer experiment is used to compare this novel geostatistical simulation method with a conventional approach based on a fine scale Cartesian grid. The results show the consistency of both the simulated permeability fields and the tracer breakthrough curves. The computational cost is much lower than the conventional approach based on a pressure-solver upscaling.

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Fichiers liés : Mourlanette et al. - 2020 - Direct simulation of non-additive properties on un.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Vivek KeshriEric ChabrièreLucile PinaultPhilippe ColsonSeydina M DieneJean-Marc RolainDidier RaoultPierre Pontarotti
• Organismes : Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : The probability of the evolution of a character depends on two factors: the probability of moving from one character state to another character state and the probability of the new character state fixation. The more the evolution of a character is probable, the more the convergent evolution will be witnessed, and consequently, convergent evolution could mean that the convergent character evolution results as a combination of these two factors. We investigated this phenomenon by studying the convergent evolution of biochemical functions. For the investigation we used the case of β-lactamases. β-lactamases hydrolyze β-lactams, which are antimicrobials able to block the DD-peptidases involved in bacterial cell wall synthesis. β-lactamase activity is present in two different superfamilies: the metallo-β-lactamase and the serine β-lactamase. The mechanism used to hydrolyze the β-lactam is different for the two superfamilies. We named this kind of evolution an allo-convergent evolution. We further showed that the β-lactamase activity evolved several times within each superfamily, a convergent evolution type that we named iso-convergent evolution. Both types of convergent evolution can be explained by the two evolutionary mechanisms discussed above. The probability of moving from one state to another is explained by the promiscuous β-lactamase activity present in the ancestral sequences of each superfamily, while the probability of fixation is explained in part by positive selection, as the organisms having β-lactamase activity allows them to resist organisms that secrete β-lactams. Indeed, an organism that has a mutation that increases the β-lactamase activity will be selected, as the organisms having this activity will have an advantage over the others.

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Fichiers liés : ijms-21-06260.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Paul GougisCharlotte FeniouxChristian Funck-BrentanoMarianne VeyriJoseph GligorovCaroline SolasJean-Philippe Spano
• Organismes : CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Tenon [AP-HP] Assistance Publique - Hôpitaux de Marseille CHU Pitié-Salpêtrière [AP-HP]
• Publié dans European Journal of Cancer le 22/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Maxime PichonCong Tri TranGaëtan MotillonCharlotte DebiaisSylvain GautierMarie AballeaJulie CremniterPhilippe VasseurDavid TougeronMagali GarciaMartine GarnierCharles BodetJean-Pierre FaureChristophe Burucoa
• Organismes : Laboratoire de Bactériologie (CHU de Poitiers) Pharmacologie des anti-infectieux [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Pharmacologie des anti-infectieux [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Service d’hépato-gastro-entérologie et assistance nutritive [CHU de Poitiers] Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Service d’hépato-gastro-entérologie et assistance nutritive [CHU de Poitiers] Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Service de Chirurgie viscérale [CHU de Poitiers] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de Bactériologie (CHU de Poitiers) Pharmacologie des anti-infectieux [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : This study aims to determine the gastric distribution, density, and diversity of Helicobacter pylori infection. Subtotal resection of the stomachs of three H. pylori-infected and asymptomatic obese patients were collected after a sleeve gastrectomy. Distribution and density of H. pylori were determined using culture and RT-PCR on multiple gastric sites (88, 176, and 101 biopsies per patient). Diversity of H. pylori strains was studied using antibiotic susceptibility testing, random amplified polymorphism DNA (RAPD) typing and cagA gene detection on single-colony isolates (44, 96, and 49 isolates per patient). H. pylori was detected in nearly all analyzed sites (354/365 biopsies, 97%). Antral density was higher in one patient only. The three stomachs were almost exclusively infected by an antibiotic-susceptible strain. One clarithromycin-resistant isolate in one biopsy was detected in two stomachs (1/44 and 1/49 isolates), while in the third one, eight (8/96 isolates) metronidazole-resistant isolates were detected. DNA typing showed infection with cagA-negative strains for one patient, cagA-positive strains for a second patient and the third patient was infected with two different strains of distinct cagA genotypes. Infection with H. pylori is shown to spread to the whole surface of the stomach, but a possibility of minor sub-population of antibiotic-resistant clones, undetectable in routine practice.

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Fichiers liés : jcm-09-02812-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Pierre-Edouard DebureauxDelphine Le Febvre de NaillyEmmanuelle TavernierManel BedouiFrederique KuhnowskiJerome TamburiniLuc ForneckerVincent CamusDavid SibonMarie-Pierre MolesSylvie GlaisnerJean Philippe RichardetSebastien MuleJulien CalderaroDaniel AzoulayJehane FadlallahCorinne HaiounJehan Dupuis
• Organismes : Interface de Recherche Fondamentale et Appliquée en Cancérologie
• Publié dans Bone Marrow Transplantation le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Damien ThiryNathan VinxPascal DammanFrancisco AparicioPierre‐yves TessierDavid MoermanPhilippe LeclèreThomas GodfroidSylvain DesprezRony Snyders
• Organismes : Centre d'Innovation et de Recherche en Matériaux Polymères Centre d'Innovation et de Recherche en Matériaux Polymères Centre d'Innovation et de Recherche en Matériaux Polymères Instituto de Ciencia de Materiales de Sevilla Institut des Matériaux Jean Rouxel Centre d'Innovation et de Recherche en Matériaux Polymères Centre d'Innovation et de Recherche en Matériaux Polymères MateriaNova Research Center MateriaNova Research Center Centre d'Innovation et de Recherche en Matériaux Polymères MateriaNova Research Center
• Publié dans Plasma Processes and Polymers le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : B. YangJosef HanušBenoit CarryPierre VernazzaM. BrožFrédéric VachierN. RambauxMichaël MarssetO. ChrenkoP. ŠevečekMatti ViikinkoskiEmmanuël JehinMarin FerraisE. Podlewska-GacaA. DrouardF. MarchisM. BirlanZ. BenkhaldounJérôme BerthierP. BartczakC. DumasG. DudzińskiJ. ĎurechJ. Castillo-RogezFabrice CiprianiF. ColasR. FetickThierry FuscoJ. GriceL. JordaM. KaasalainenA. KryszczynskaPhilippe LamyAlexandre MarciniakT. MichalowskiPatrick MichelM. PajueloToni Santana-RosP. TangaArthur ViganOlivier Witasse
• Organismes : European Southern Observatory [Santiago] Institute of Astronomy [Prague] Joseph Louis LAGRANGE Laboratoire d'Astrophysique de Marseille Institute of Astronomy [Prague] Institut de Mécanique Céleste et de Calcul des Ephémérides Institut de Mécanique Céleste et de Calcul des Ephémérides Department of Earth, Atmospheric and Planetary Sciences [MIT, Cambridge] Institute of Astronomy [Prague] Institute of Astronomy [Prague] University of Tampere [Finland] Space Sciences, Technologies and Astrophysics Research Institute Laboratoire d'Astrophysique de Marseille Astronomical Observatory [Poznan] Laboratoire d'Astrophysique de Marseille Search for Extraterrestrial Intelligence Institute Institut de Mécanique Céleste et de Calcul des Ephémérides Astronomical Institute of Romanian Academy Oukaimeden Observatory Institut de Mécanique Céleste et de Calcul des Ephémérides Astronomical Observatory [Poznan] Thirty Meter Telescope Observatory Astronomical Observatory [Poznan] Institute of Astronomy [Prague] Jet Propulsion Laboratory European Space Research and Technology Centre Institut de Mécanique Céleste et de Calcul des Ephémérides Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille DOTA, ONERA, Université Paris Saclay [Palaiseau] Joseph Louis LAGRANGE School of Physical Sciences [Milton Keynes] Laboratoire d'Astrophysique de Marseille University of Tampere [Finland] Astronomical Observatory [Poznan] PLANETO - LATMOS Astronomical Observatory [Poznan] Astronomical Observatory [Poznan] Joseph Louis LAGRANGE Institut de Mécanique Céleste et de Calcul des Ephémérides Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru Universidad de Alicante Institut de Ciencies del Cosmos Joseph Louis LAGRANGE Laboratoire d'Astrophysique de Marseille European Space Research and Technology Centre
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Aims. Asteroid (31) Euphrosyne is one of the biggest objects in the asteroid main belt and it is also the largest member of its namesake family. The Euphrosyne family occupies a highly inclined region in the outer main belt and contains a remarkably large number of members, which is interpreted as an outcome of a disruptive cratering event. Methods. The goals of this adaptive-optics imaging study are threefold: to characterize the shape of Euphrosyne, to constrain its density, and to search for the large craters that may be associated with the family formation event. Results. We obtained disk-resolved images of Euphrosyne using SPHERE/ZIMPOL at the ESO 8.2 m VLT as part of our large program (ID: 199.C-0074, PI: Vernazza). We reconstructed its 3D shape via the ADAM shape modeling algorithm based on the SPHERE images and the available light curves of this asteroid. We analyzed the dynamics of the satellite with the Genoid meta-heuristic algorithm. Finally, we studied the shape of Euphrosyne using hydrostatic equilibrium models. Conclusions. Our SPHERE observations show that Euphrosyne has a nearly spherical shape with the sphericity index of 0.9888 and its surface lacks large impact craters. Euphrosyne’s diameter is 268 ± 6 km, making it one of the top ten largest main belt asteroids. We detected a satellite of Euphrosyne – S/2019 (31) 1 – that is about 4 km across, on a circular orbit. The mass determined from the orbit of the satellite together with the volume computed from the shape model imply a density of 1665 ± 242 kg m−3, suggesting that Euphrosyne probably contains a large fraction of water ice in its interior. We find that the spherical shape of Euphrosyne is a result of the reaccumulation process following the impact, as in the case of (10) Hygiea. However, our shape analysis reveals that, contrary to Hygiea, the axis ratios of Euphrosyne significantly differ from those suggested by fluid hydrostatic equilibrium following reaccumulation.

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Fichiers liés : aa38372-20.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Audrey MonninNicolas NagotMarianne PerièsR. ValloNicolas MedaMandisa Singata-MadlikiJames TumwineChipepo KankasaNobubelo NganduAmeena GogaPascal ReynierThorkild TylleskärPhilippe Van De PerreJean-Pierre Moles
• Organismes : Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections Pathogénèse et contrôle des infections chroniques (PCCI) Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections Centre Muraz [Bobo-Dioulasso, Burkina Faso] University of Fort Hare Makerere University [Kampala, Ouganda] University Teaching Hospital [Lusaka] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] Département de Biochimie et Génétique [Angers] Centre for International Health [Bergen, Norway] Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections Pathogénèse et contrôle des infections chroniques (PCCI) Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Fichiers liés : jcm-09-02972-v3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2020
• Auteurs : Yi-Chun Xu-DuboisPedram AhmadpoorIsabelle BrocheriouKevin LouisNadia ArzoukPhilippe RouvierJean-Luc TaupinAnthony CorchiaPierre GalichonBenoît BarrouSébastien GiraudThierry HauetChantal JouanneauAnita RodenasSandrine PlacierAïssata NiasseSouhila OucheloucheBen-Youssef NaimiElsa AkilAlexandre HertigDavid BuobEric Rondeau
• Organismes : Sorbonne Université Institut National de la Santé et de la Recherche Médicale CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université Institut National de la Santé et de la Recherche Médicale CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Service d'Immunologie et d'Histocompatibilité Institut Universitaire d'Hématologie Sorbonne Université Institut National de la Santé et de la Recherche Médicale Sorbonne Université Institut National de la Santé et de la Recherche Médicale CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Pôle Biospharm (biologie pharmacie santé publique) [CHU de Poitiers] = Biology, Pharmacy, Public Health Department [Poitiers University Hospital] Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques [U 1082] Pôle Biospharm (biologie pharmacie santé publique) [CHU de Poitiers] = Biology, Pharmacy, Public Health Department [Poitiers University Hospital] Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques [U 1082] Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Sorbonne Université Institut National de la Santé et de la Recherche Médicale CHU Tenon [AP-HP] Sorbonne Université Institut National de la Santé et de la Recherche Médicale Sorbonne Université Institut National de la Santé et de la Recherche Médicale Sorbonne Université Institut National de la Santé et de la Recherche Médicale Laboratoire AnyGenes Laboratoire AnyGenes Sorbonne Université Institut National de la Santé et de la Recherche Médicale CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université Institut National de la Santé et de la Recherche Médicale CHU Tenon [AP-HP] Sorbonne Université Institut National de la Santé et de la Recherche Médicale CHU Tenon [AP-HP]
• Publié dans American Journal of Transplantation le 26/10/2020

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Résumé : Acute tubular necrosis (ATN), a frequent histopathological feature in the early post–renal transplant biopsy, affects long-term graft function. Appropriate markers to identify patients at risk of no or incomplete recovery after delayed graft function are lacking. In this study, we first included 41 renal transplant patients whose biopsy for cause during the first month after transplantation showed ATN lesions. Using partial microvasculature endothelial (fascin, vimentin) and tubular epithelial (vimentin) to mesenchymal transition markers, detected by immunohistochemistry, we found a significant association between partial endothelial to mesenchymal transition and poor graft function recovery (Spearman’s rho = −0.55, P = .0005). Transforming growth factor–β1 was strongly expressed in these phenotypic changed endothelial cells. Extent of ATN was also correlated with short- and long-term graft dysfunction. However, the association of extensive ATN with long-term graft dysfunction (24 months posttransplant) was observed only in patients with partial endothelial to mesenchymal transition marker expression in their grafts (Spearman’s rho = −0.64, P = .003), but not in those without. The association of partial endothelial to mesenchymal transition with worse renal graft outcome was confirmed on 34 other early biopsies with ATN from a second transplant center. Our results suggest that endothelial cell activation at the early phase of renal transplantation plays a detrimental role.

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