Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 26/08/2020
• Auteurs : Lorène ZerahÉdouard BaudouinMarion PépinMorgane MarySébastien KrypciakCéline BiancoSwasti RouxAriane GrossCharlotte ToméoNadège LemariéAntoine DureauSophie BastianiFlora KetzClémence BoullyCédric de VillelongueMouna RomdhaniMarie-Astrid DesoutterEmmanuelle DuronJean-Philippe DavidCaroline ThomasEléna PaillaudPauline de MalglaiveEric BouvardMathilde LacrampeElise MercadierAlexandra MontiOlivier HanonVirginie Fossey-DiazLauriane BourdonnecBruno RiouH. ValletJacques Boddaert
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations Hôpital Paul Brousse CHU Henri Mondor [Créteil] Institut Mondor de Recherche Biomédicale CHU Saint-Antoine [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Hôpital Corentin Celton [Issy-les-Moulineaux] CIC - CHU Bichat CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] Sorbonne Université - Faculté de Médecine CHU Rothschild [AP-HP] Sorbonne Université - Faculté de Médecine AP-HP - Hôpital Antoine Béclère [Clamart] CHU Charles Foix [AP-HP] Sorbonne Université - Faculté de Médecine AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours Centre de recherche en épidémiologie et santé des populations Hôpital Ambroise Paré [AP-HP] Hôpital Paul Brousse Institut Mondor de Recherche Biomédicale CHU Henri Mondor [Créteil] CHU Saint-Antoine [AP-HP] Institut Mondor de Recherche Biomédicale Hôpital Européen Georges Pompidou [APHP] IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" [Créteil] CIC - CHU Bichat CHU Tenon [AP-HP] Sorbonne Université - Faculté de Médecine CHU Rothschild [AP-HP] Sorbonne Université - Faculté de Médecine AP-HP - Hôpital Antoine Béclère [Clamart] CHU Charles Foix [AP-HP] Sorbonne Université - Faculté de Médecine AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université - Faculté de Médecine Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Centre d'Immunologie et des Maladies Infectieuses CHU Saint-Antoine [AP-HP] Centre d'Immunologie et des Maladies Infectieuses CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Background: There is limited information describing the characteristics and outcomes of hospitalized older patients with confirmed coronavirus disease 2019 (COVID-19). Methods: We conducted a multicentric retrospective cohort study in 13 acute COVID-19 geriatric wards, from March 13 to April 15, 2020, in Paris area. All consecutive patients aged ≥ 70 years, with confirmed COVID-19, were enrolled. Results: Of the 821 patients included in the study, the mean (SD) age was 86 (7) years; 58% were female; 85% had ≥ 2 comorbidities; 29% lived in an institution; and the median (interquartile range) Activities of Daily Living Scale (ADL) score was 4 [2-6]. The most common symptoms at COVID-19 onset were asthenia (63%), fever (55%), dyspnea (45%), dry cough (45%) and delirium (25%). The in-hospital mortality was 31% (95% confidence interval [CI], 27 to 33). On multivariate analysis, at COVID-19 onset, the probability of in-hospital mortality was increased with male gender (odds ratio [OR], 1.85; 95% CI, 1.30 to 2.63), ADL score < 4 (OR, 1.84; 95% CI, 1.25 to 2.70), asthenia (OR, 1.59; 95% CI, 1.08 to 2.32), quick Sequential Organ Failure Assessment score ≥ 2 (OR, 2.63; 95% CI, 1.64 to 4.22) and specific COVID-19 anomalies on chest computerized tomography (OR, 2.60; 95% CI, 1.07 to 6.46). Conclusions: This study provides new information about older patients with COVID-19 who are hospitalized. A quick bedside evaluation at admission of sex, functional status, systolic arterial pressure, consciousness, respiratory rate and asthenia can identify older patients at risk of unfavorable outcomes.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/08/2020
• Auteurs : Pierre AmarencoCristina HobeanuJulien LabreucheHugo CharlesMaurice GiroudElena MeseguerPhilippa LavalléePhilippe Gabriel StegÉric VicautÉric BruckertPierre-Jean Touboul
• Organismes : Laboratoire de Recherche Vasculaire Translationnelle Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Circulation le 29/10/2020

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Résumé : Background: The TST trial (Treat Stroke to Target) showed the benefit of targeting a low-density lipoprotein cholesterol (LDL-C) concentration of <70 mg/dL in terms of reducing the risk of major cardiovascular events in 2860 patients with ischemic stroke with atherosclerotic stenosis of cerebral vasculature. The impact on carotid atherosclerosis evolution is not known. Methods: TST-PLUS (Treat Stroke to Target–Plaque Ultrasound Study) included 201 patients assigned to an LDL-C concentration of <70 mg/dL and 212 patients assigned to a target of 100±10 mg/dL. To achieve these goals, investigators used the statin and dosage of their choice and added ezetimibe as needed. Ultrasonographers were certified and carotid ultrasound examinations were performed using M′Ath software at baseline and at 2, 3, and 5 years. All images were uploaded to the Intelligence in Medical Technologies database directly from the carotid ultrasound device. The central core laboratory performed all offline measurements of the intima–media thickness of both common carotid arteries blinded from the randomization arm. The main outcomes were newly diagnosed atherosclerotic plaque on carotid bifurcation or internal carotid artery using the Mannheim consensus definition and between-group comparison of common carotid arteries intima–media thickness change. Results: After a median follow-up of 3.1 years, the achieved LDL-C concentrations were 64 mg/dL (1.64 mmol/L) in the lower-target group and 106 mg/dL (2.72 mmol/L) in the higher-target group. Compared with the higher-target group, patients in the lower-target group had a similar incidence of newly diagnosed carotid plaque: 46/201 (5-year rate, 26.1%) versus 45/212 (5-year rate, 29.7%). The change in common carotid arteries intima–media thickness was −2.69 µm (95% CI, −6.55 to 1.18) in the higher-target group and −10.53 µm (95% CI, −14.21 to −6.85) in the lower-target group, resulting in an absolute between-group difference of −7.84 µm (95% CI, −13.18 to −2.51; P =0.004). Conclusions: In patients with ischemic stroke and atherosclerosis, an LDL-C target of <70 mg/dL (1.8 mmol/L) did not reduce the incidence of new carotid plaques but produced significantly greater regression of carotid atherosclerosis than an LDL-C target of 90 to 110 mg/dL. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01252875.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/08/2020
• Auteurs : Pierre-Yves DumasSarah BertoliEmilie BérardThibaut LeguaySuzanne TavitianJean GaltierCamille AlricAudrey BidetEric DelabesseJean-Baptiste RieuJean-Philippe VialFrançois VergezNicolas LechevalierIsabelle LuquetEmilie KleinAudrey SarryHéloïse ReyAnne-Charlotte de GrandeFabien DespasArnaud PigneuxChristian Récher
• Organismes : CHU de Bordeaux Pellegrin [Bordeaux] Université de Bordeaux Biothérapies des maladies génétiques et cancers Service Hématologie - IUCT-Oncopole [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Service Epidémiologie clinique et santé publique [CHU Toulouse] CHU de Bordeaux Pellegrin [Bordeaux] Service Hématologie - IUCT-Oncopole [CHU Toulouse] CHU de Bordeaux Pellegrin [Bordeaux] Service Hématologie - IUCT-Oncopole [CHU Toulouse] CHU de Bordeaux Pellegrin [Bordeaux] Centre de Recherches en Cancérologie de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] Service Hématologie - IUCT-Oncopole [CHU Toulouse] CHU de Bordeaux Pellegrin [Bordeaux] Laboratoire Hématologie - Rangueil [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Service Hématologie - IUCT-Oncopole [CHU Toulouse] CHU de Bordeaux Pellegrin [Bordeaux] Service Hématologie - IUCT-Oncopole [CHU Toulouse] CHU de Bordeaux Pellegrin [Bordeaux] Service Hématologie - IUCT-Oncopole [CHU Toulouse] Service Hématologie - IUCT-Oncopole [CHU Toulouse] CHU de Bordeaux Pellegrin [Bordeaux] Centre d'investigation clinique de Toulouse Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps CHU de Bordeaux Pellegrin [Bordeaux] Université de Bordeaux Biothérapies des maladies génétiques et cancers Service Hématologie - IUCT-Oncopole [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse
• Publié dans Blood Advances le 24/10/2020

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Résumé : Postremission treatment is crucial to prevent relapse in acute myeloid leukemia (AML). High-dose cytarabine delivered every 12 hours on days 1, 3, and 5 (HDAC-135) is the standard of care for younger adult patients with AML. Although this standard has been unsuccessfully challenged by other treatment regimens, including multiagent chemotherapy, the timing of HDAC administration has attracted little attention. Here, we retrospectively compared the safety, efficacy, and health care resource consumption associated with HDAC-135 and another standard, condensed HDAC-123 regimen, as consolidation treatment in younger AML patients in first complete response. This study included 221 patients (median age, 46.6 years; range, 18-60 years). HDAC-123 and HDAC-135 were used in 92 and 129 patients, respectively. Both regimens were associated with similar rates of relapse-free survival, cumulative incidence of relapse, nonrelapse mortality, and overall survival, including in core binding factor AML subgroup in which levels of minimal residual disease reduction were similar in both schedules. Hematological recovery times regarding neutrophils and platelets were significantly shorter in patients receiving HDAC-123, with an average difference of 3 to 4 days for each consolidation cycle. The total duration of hospitalization for the whole postremission program was shorter with HDAC-123 (32 days; interquartile ratio [IQR], 22.0,36.5) compared with HDAC-135 (41 days; IQR, 30.5, 50.0) (P < .0001). In conclusion, the condensed HDAC-123 regimen induced faster hematological recovery and therefore significantly reduced the length of hospital stay without affecting treatment response or outcome in younger AML patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/08/2020
• Auteurs : Christophe Le TourneauJean-Pierre DelordNuria KoteckiEdith BorcomanCarlos Gomez-RocaSégolène HescotChristiane JungelsAnne Vincent-SalomonVincent CockenpotLauriane EberstAudrey MoléWael JdeyFrançoise BonoVéronique Trochon-JosephHélène ToussaintChristelle ZandanelOlga AdamiecOlivier de BeaumontPhilippe Alexandre Cassier
• Organismes : Centre de Recherches en Cancérologie de Toulouse Oncopole Claudius Regaud Institut Universitaire du Cancer de Toulouse - Oncopole
• Publié dans British Journal of Cancer le 29/10/2020

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Résumé : Abstract Background AsiDNA, a first-in-class oligonucleotide-mimicking double-stranded DNA breaks, acts as a decoy agonist to DNA damage response in tumour cells. It also activates DNA-dependent protein kinase and poly (adenosine diphosphate [ADP]-ribose) polymerase enzymes that induce phosphorylation of H2AX and protein PARylation. Methods The aim of this Phase 1 study was to determine dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), safety and pharmacokinetics/pharmacodynamics of AsiDNA administered daily for 3 days in the first week then weekly thereafter. Twenty-two patients with advanced solid tumours were enrolled in 5 dose levels: 200, 400, 600, 900, and 1300 mg, using a 3 + 3 design. Results The MTD was not reached. IV AsiDNA was safe. Two DLTs (grade 4 and grade 3 hepatic enzymes increased at 900 and 1300 mg), and two related SAE at 900 mg (grade 3 hypotension and grade 4 hepatic enzymes increased) were reported. AsiDNA PK increased proportionally with dose. A robust activation of DNA-PK by a significant posttreatment increase of γH2AX was evidenced in tumour biopsies. Conclusion The dose of 600 mg was identified as the optimal dose for further clinical development. Clinical trial registration Clinical trial registration (NCT number): NCT03579628.

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• Type de publi. : Article dans une revue
• Date de publi. : 21/08/2020
• Auteurs : Karina von SchuckmannPierre-Yves Le TraonNeville SmithAnanda PascualSamuel DjavidniaJean-Pierre GattusoMarilaure GrégoireGlenn NolanSigne AaboeEnrique Álvarez FanjulLotfi AoufRoland AznarT. BadewienArno BehrensMaristella BertaLaurent BertinoJeremy BlackfordGiorgio BolzonFederica BorileMarine BretagnonRobert J.W. BrewinDonata CanuPaola CessiStefano CiavattaBertrand ChapronThi-Tuyet-Trang ChauFrederic ChevallierBoriana ChtirkovaStefania CilibertiJames ClarkEmanuela ClementiClément CombotEric ComermaAnna ConchonGiovanni CoppiniLorenzo CorgnatiGianpiero CossariniSophie CravatteMarta de AlfonsoClément de Boyer MontégutChristian de Lera FernándezFrancisco Javier de Los SantosAnna Denvil-SommerÁlvaro de Pascual CollarPaulo Alonso Lourenco Dias NunesValeria Di BiagioMassimiliano DrudiOwen EmburyPierpaolo FalcoOdile Fanton D’andonLuis FerrerDavid FordH. FreundManuel García LeónMarcos García SotilloJosé María García-ValdecasasPhilippe GarnessonGilles GarricFlorent GasparinMarion GehlenAna Genua-OlmedoGerhard GeyerAndrea GhermandiSimon GoodJérôme GourrionEric GreinerAnnalisa GriffaManuel GonzálezIsmael Hernández-CarrascoStéphane IsoardJohn KennedySusan KayAnton KorosovKaari LaanemäePeter LandThomas LavergneFabrizio d'OrtenzioJean-François LegeaisBenedicte LemieuxBruno LevierWilliam LlovelVladyslav LyubartsevVidar LienLeonardo LimaPablo LorenteJulien MaderMarcello MagaldiIlja MaljutenkoAntoine ManginCarlo MantovaniVeselka MarinovaSimona MasinaElena MauriJ. MeyerjürgensAlexandre MignotRobert McewanCarlos MejiaAngélique MeletMilena MennaBenoit MeyssignacAlexis MoucheBaptiste MourreMalte MüllerGiulio NotarstefanoAlejandro OrfilaSilvia PardoElisaveta PenevaBegoña Pérez-GómezCoralie PerrucheMonika PeterlinPierre-Marie PoulainNadia PinardiYves QuilfenUrmas RaudseppRichard RenshawAdèle RévelardEmma Reyes-ReyesM. RickerPablo Rodríguez-RubioPaz RotllánEva Royo GelabertAnna RubioInmaculada Ruiz-ParradoShubha SathyendranathJun SheCosimo SolidoroEmil StanevJoanna StanevaAndrea StortoJian SuTayebeh Tajalli BakhshGavin TilstoneJoaquín TintoréCristina ToledanoJean TournadreBenoit TranchantRivo UiboupinArnaud ValcarcelNadezhda ValchevaNathalie VerbruggeMathieu VracJ.-O. WolffEnrico ZambianchiO. ZielinskiAnn-Sofie ZinckSerena Zunino
• Organismes : Mercator Océan Mercator Océan Pacific community [Nouméa, nouvelle Calédonie] Institut Mediterrani d'Estudis Avancats = Instituto Mediterráneo de Estudios Avanzados Laboratoire d'océanographie de Villefranche Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Marine Institute [Oranmore] Norwegian Meteorological Institute [Oslo] Météo-France Direction Interrégionale Sud-Est Puertos del estado Helmholtz-Zentrum Geesthacht Istituto di Science Marine Nansen Environmental and Remote Sensing Center [Bergen] Istituto Nazionale di Oceanografia e di Geofisica Sperimentale = National Institute of Oceanography and Experimental Geophysics Analytic and Computational Research, Inc. - Earth Sciences Centre for Geography and Environmental Science Istituto Nazionale di Oceanografia e di Geofisica Sperimentale = National Institute of Oceanography and Experimental Geophysics Laboratoire d'Océanographie Physique et Spatiale Laboratoire d'études en Géophysique et océanographie spatiales Mercator Océan Mercator Océan Mercator Océan Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Extrèmes : Statistiques, Impacts et Régionalisation
• Publié dans Journal of Operational Oceanography le 27/10/2020

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Fichiers liés : report.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 19/08/2020
• Auteurs : Jean-Pierre VidalCécile AntignyChristophe BittoloPhilippe DrweskiLéa RenoufRaphaël RiandAnne-Clémence Schom
• Organismes : Université Montpellier 2 - Sciences et Techniques Centre de recherches éducation et formation Laboratoire de Psychologie Clinique, Psychopathologie, Psychanalyse Bien-Être et Processus de Subjectivation Laboratoire de Psychologie Clinique, Psychopathologie, Psychanalyse
• Publié dans Revue de psychothérapie Psychanalytique de Groupes le 31/10/2020

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Résumé : Cet entretien s’inscrit dans une démarche de réflexion sur l’épistémologie et la méthodologie dans l’approche psychanalytique des groupes. Les spécificités de ce champ théorique imposent des aménagements méthodologiques incontournables que nous souhaiterions interroger à travers une série d’entretiens de cliniciens-chercheurs ayant travaillé sur ces questions. Le premier de cette série est consacré à Jean-Pierre Vidal. Psychanalyste et analyste de groupe et d’institution, il développe, dans cet entretien, ses conceptions sur la formation des psychologues et la nécessaire décentration de l’écoute et du regard imposée par le changement de paradigme dans les pratiques psychanalytiques de groupe.

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• Type de publi. : Article dans une revue
• Date de publi. : 17/08/2020
• Auteurs : Paolo LajAlessandro BigiClémence RoseElisabeth AndrewsCathrine Lund MyhreMartine Collaud CoenYong LinAlfred WiedensohlerMichael SchulzJohn A OgrenMarkus FiebigJonas GlissAugustin MortierMarco PandolfiTuukka PetäjäSang-Woo KimWenche AasJean-Philippe PutaudOlga Mayol-BraceroMelita KeywoodLorenzo LabradorPasi AaltoErik AhlbergLucas Alados ArboledasAndrés AlastueyMarcos AndradeBegona ArtinanoStina AusmeelTodor ArsovEija AsmiJohn BackmanUrs BaltenspergerSusanne BastianOlaf BathJohan Paul BeukesBenjamin T BremNicolas BukowieckiSébastien ConilCedric CouretDerek DayWan DayantolisAnna DegorskaKonstantinos EleftheriadisProdromos FetfatzisOlivier FavezHarald FlentjeMaria GiniAsta GregoričMartin Gysel-BeerA Gannet HallarJenny HandAndras HofferChristoph HueglinRakesh K HoodaAntti HyvärinenIvo KalapovNikos KalivitisAnne Kasper-GieblJeong Eun KimGiorgos KouvarakisIrena KranjcRadovan KrejciMarkku KulmalaCasper LabuschagneHae-Jung LeeHeikki LihavainenNeng-Huei LinGunter LöschauKrista LuomaAngela MarinoniSebastiao MartinsDos SantosFrank MeinhardtMaik MerkelJean-Marc MetzgerNikolaos MihalopoulosNhat Anh NguyenJakub OndracekNoemi PérezMaria Rita PerroneJean-Eudes PetitDavid PicardJean-Marc PichonVéronique PontNatalia PratsAnthony PrenniFabienne ReisenSalvatore RomanoKarine SellegriSangeeta SharmaGerhard SchauerPatrick SheridanJames Patrick ShermanMaik SchützeAndreas SchwerinRalf SohmerMartin SteinbacherJunying SunGloria TitosBarbara ToczkoThomas TuchPierre TuletPeter TunvedVille VakkariFernando VelardePatricio VelasquezPaolo VillaniSterios VratolisSheng-Hsiang WangKay WeinholdRolf WellerMargarita YelaJesus Yus-DiezVladimir ZdimalPaul ZiegerNadezda Zikova
• Organismes : Institut des Géosciences de l’Environnement National Research Council of Italy | Consiglio Nazionale delle Ricerche Institute for Atmospheric and Earth System Research Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia Laboratoire de Météorologie Physique Cooperative Institute for Research in Environmental Sciences NOAA Earth System Research Laboratory Norwegian Institute for Air Research Federal Office of Meteorology and Climatology MeteoSwiss Norwegian Institute for Air Research Leibniz Institute for Tropospheric Research Norwegian Meteorological Institute [Oslo] Norwegian Institute for Air Research Norwegian Meteorological Institute [Oslo] Institute of Environmental Assessment and Water Research Helsingin yliopisto = Helsingfors universitet = University of Helsinki School of Earth and Environmental Sciences [Seoul] Norwegian Institute for Air Research JRC Institute for Environment and Sustainability Universidad Mayor de San Andrés Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas Finnish Meteorological Institute Paul Scherrer Institute Laboratory of Atmospheric Chemistry [Paul Scherrer Institute] Agence Nationale pour la Gestion des Déchets Radioactifs Iinstitute of Environmental Protection - National Research Institute Environmental Radioactivity laboratory National Center for Scientific Research "Demokritos" Institut National de l'Environnement Industriel et des Risques Deutscher Wetterdienst [Offenbach] Department of Computer Science and Engineering [Minneapolis] Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] Arctic Space Centre [Helsinki] Bulgarian Academy of Sciences = Académie bulgare des sciences [Académie des sciences de Bulgarie] = Българска академия на науките University of Crete [Heraklion] Institute for Chemical Technologies and Analytics Environmental Chemical Processes Laboratory [Heraklion] Department of Environmental Science and Analytical Chemistry [Stockholm] South African Weather Service Finnish Meteorological Institute Department of Medicine [New York] Observatoire des Sciences de l'Univers de La Réunion Institute for Environmental Research and Sustainable Development Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Chimie Atmosphérique Expérimentale Laboratoire de Météorologie Physique Laboratoire de Météorologie Physique Laboratoire d'aérologie NERC National Centre for Earth Observation Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] Laboratoire de l'Atmosphère et des Cyclones Institute for Applied Environmental Research [Stockholm] Universidad Mayor de San Andrés Environmental Radioactivity laboratory Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung = Alfred Wegener Institute for Polar and Marine Research = Institut Alfred-Wegener pour la recherche polaire et marine Instituto Nacional de Técnica Aeroespacial Stockholm University
• Publié dans Atmospheric Measurement Techniques le 24/10/2020

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Résumé : Aerosol particles are essential constituents of the Earth's atmosphere, impacting the earth radiation balance directly by scattering and absorbing solar radiation, and indirectly by acting as cloud condensation nuclei. In contrast to most greenhouse gases, aerosol particles have short atmospheric residence times, resulting in a highly heterogeneous distribution in space and time. There is a clear need to document this variability at regional scale through observations involving, in particular, the in situ near-surface segment of the atmospheric observation system. This paper will provide the widest effort so far to document variability of climate-relevant in situ aerosol properties (namely wavelength dependent particle light scattering and absorption coefficients, particle number concentration and particle number size distribution) from all sites connected to the Global Atmosphere Watch network. High-quality data from almost 90 stations worldwide have been collected and controlled for quality and are reported for a reference year in 2017, providing a very extended and robust view of the variability of these variables worldwide. The range of variability observed worldwide for light scattering and absorption coefficients, single-scattering albedo, and particle number concentration are presented together with preliminary information on their long-term trends and comparison with model simulation for the different stations. The scope of the present paper is also to provide the necessary suite of information, including data provision procedures, quality control and analysis, data policy, and usage of the ground-based aerosol measurement network. It delivers to users of the World Data Centre on Aerosol, the required confidence in data products in the form of a fully characterized value chain, including uncertainty estimation and requirements for contributing to the global climate monitoring system.

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Fichiers liés : amt-13-4353-2020.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/08/2020
• Auteurs : Roman GauchiV. EgloffMaha KooliJean-Philippe NoëlBastien GiraudPascal VivetSubhasish MitraHenri-Pierre Charles
• Organismes : Commissariat à l'énergie atomique et aux énergies alternatives Université Grenoble Alpes Commissariat à l'énergie atomique et aux énergies alternatives Université Grenoble Alpes Commissariat à l'énergie atomique et aux énergies alternatives Université Grenoble Alpes Commissariat à l'énergie atomique et aux énergies alternatives Université Grenoble Alpes Commissariat à l'énergie atomique et aux énergies alternatives Université Grenoble Alpes Commissariat à l'énergie atomique et aux énergies alternatives Université Grenoble Alpes Stanford University Commissariat à l'énergie atomique et aux énergies alternatives Université Grenoble Alpes Laboratoire Fonctions Innovantes pour circuits Mixtes

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Résumé : For big data applications, bringing computation to the memory is expected to reduce drastically data transfers, which can be done using recent concepts of Computing-In-Memory (CIM). To address kernels with larger memory data sets, we propose a reconfigurable tile-based architecture composed of Computational-SRAM (C-SRAM) tiles, each enabling arithmetic and logic operations within the memory. The proposed horizontal scalability and vertical data communication are combined to select the optimal vector width for maximum performance. These schemes allow to use vector-based kernels available on existing SIMD engines onto the targeted CIM architecture. For architecture exploration, we propose an instruction-accurate simulation platform using SystemC/TLM to quantify performance and energy of various kernels. For detailed performance evaluation, the platform is calibrated with data extracted from the Place&Route C-SRAM circuit, designed in 22nm FDSOI technology. Compared to 512-bit SIMD architecture, the proposed CIM architecture achieves an EDP reduction up to 60× and 34× for memory bound kernels and for compute bound kernels, respectively.

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Fichiers liés : ISLPED_2020_paper.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 07/08/2020
• Auteurs : Arnaud ThivoletSalim Si-MohamedPierre-Emmanuel BonnotChristophe BlanchetVahan KépénékianL. BousselPhilippe DouekPascal Rousset
• Organismes : Radiology Department [Lyon] Ciblage thérapeutique en Oncologie Université Claude Bernard Lyon 1 Radiology Department [Lyon] Université Claude Bernard Lyon 1 Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Ciblage thérapeutique en Oncologie Université Claude Bernard Lyon 1 Surgical Department [Lyon] Pathology Department [Lyon] Ciblage thérapeutique en Oncologie Université Claude Bernard Lyon 1 Surgical Department [Lyon] Radiology Department [Lyon] Université Claude Bernard Lyon 1 Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis Radiology Department [Lyon] Université Claude Bernard Lyon 1 Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis Radiology Department [Lyon] Ciblage thérapeutique en Oncologie Université Claude Bernard Lyon 1
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Computed tomography imaging plays a major role in the preoperative assessment of tumor burden by providing an accurate mapping of the distribution of peritoneal metastases (PM). Spectral Photon Counting Computed Tomography (SPCCT) is an innovative imaging modality that could overcome the current limitations of conventional CT, offering not only better spatial resolution but also better contrast resolution by allowing the discrimination of multiple contrast agents. Based on this capability, we tested the feasibility of SPCCT in the detection of PM at different time of tumor growth in 16 rats inoculated with CC531 cells using dual-contrast injection protocols in two compartments (i.e. intravenous iodine and intraperitoneal gadolinium or the reverse protocol), compared to surgery. For all peritoneal regions and for both protocols, sensitivity was 69%, specificity was 100% and accuracy was 80%, and the correlation with surgical exploration was strong (p = 0.97; p = 0.0001). No significant difference was found in terms of diagnostic performance, quality of peritoneal opacification or diagnostic quality between the 2 injection protocols. We also showed poor vascularization of peritoneal metastases by measuring low concentrations of contrast agent in the largest lesions using SPCCT, which was confirmed by immunohistochemical analyses. In conclusion, SPCCT using dual-contrast agent injection protocols in 2 compartments is a promising imaging modality to assess the extent of PM in a rat model.

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Fichiers liés : s41598-020-70282-w.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/08/2020
• Auteurs : Pierre CharlesÉlodie PerrodeauMaxime SamsonBernard BonnotteAntoine NéelChristian AgardAntoine HuartAlexandre KarrasFrançois LifermannPascal GodmerPascal CohenCatherine Hanrotel-SaliouNicolas Martin-SilvaGrégory PugnetFrançois MaurierJean SibiliaPierre-Louis CarronPierre GobertNadine Meaux-RuaultThomas Le GallouStéphane VinzioJean-François ViallardÉric HachullaChristine VinterXavier PuéchalBenjamin TerrierPhilippe RavaudLuc MouthonLoïc Guillevin
• Organismes : Centre de Recherche en Transplantation et Immunologie Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Immuno-Rhumatologie Moléculaire
• Publié dans Annals of Internal Medicine le 25/10/2020

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Résumé : Biannual rituximab infusions over 18 months effectively maintain remission after a “standard” remission induction regimen for patients with antineutrophil cytoplasmic antibody–associated vasculitis (AAV)

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