Non-influenza respiratory viruses in adult patients admitted with influenza-like illness a 3-year prospective multicenter study
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2020
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Auteurs :
François BenezitPaul LoubetFlorence GaltierCharlotte PronierNezha LenziZineb LesieurStéphane JouneauGisèle LagathuAnne-Sophie L’honneurVincent FoulongneChristine VallejoSophie AlainXavier DuvalNawal HouhouYolande CostaPhilippe VanhemsSélilah AmourFabrice CarratBruno LinaOdile LaunayPierre Tattevin
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Organismes :
Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
Université de Rennes
F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
CIC Cochin Pasteur
CIC Montpellier
F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
Biocommunication en Cardio-Métabolique
Centre Hospitalier Régional Universitaire [Montpellier]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Université de Rennes
F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
CIC Cochin Pasteur
F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
CIC Cochin Pasteur
Centre d'Investigation Clinique [Rennes]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Université de Rennes
Service de Virologie [CHU Cochin]
Hôpital Saint Eloi [CHU Montpellier]
Centre d'Investigation Clinique de Limoges
Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
CIC Hôpital Bichat
Service de Virologie [CHU Bichat]
F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
CIC Hôpital Bichat
Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL]
Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]
Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL]
Institut Pierre Louis d'Epidémiologie et de Santé Publique
Institut des Agents Infectieux [Lyon]
F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
Université Paris Cité
Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
Université de Rennes
Centre d'Investigation Clinique [Rennes]
- Publié dans Infection le 27/10/2020
Résumé : Purpose - To describe the burden, and characteristics, of influenza-like illness (ILI) associated with non-influenza respiratory viruses (NIRV). Methods - We performed a prospective, multicenter, observational study of adults admitted with ILI during three influenza seasons (2012-2015). Patients were screened for picornavirus, respiratory syncytial virus (RSV), coronavirus, human metapneumovirus, adenovirus, bocavirus, parainfluenza virus, and influenza, by PCR on nasopharyngeal samples. We excluded patients coinfected with NIRV and influenza.Results - Among 1421 patients enrolled, influenza virus was detected in 535 (38%), and NIRV in 215 (15%), mostly picornavirus (n = 61), RSV (n = 53), coronavirus 229E (n = 48), and human metapneumovirus (n = 40). In-hospital mortality was 5% (NIRV), 4% (influenza), and 5% (no respiratory virus). As compared to influenza, NIRV were associated with age (median, 73 years vs. 68, P = 0.026), chronic respiratory diseases (53% vs. 45%, P = 0.034), cancer (14% vs. 9%, P = 0.029), and immunosuppressive drugs (21% vs. 14%, P = 0.028), and inversely associated with diabetes (18% vs. 25%, P = 0.038). On multivariable analysis, only chronic respiratory diseases (OR 1.5 [1.1-2.0], P = 0.008), and diabetes (OR 0.5 [0.4-0.8], P = 0.01) were associated with NIRV detection.Conclusions - NIRV are common in adults admitted with ILI during influenza seasons. Outcomes are similar in patients with NIRV, influenza, or no respiratory virus.
Fichiers liés :
Benezit et al-2020-Non-influenza respiratory viruses in adult patients admitted.pdf
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