Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/07/2020
• Auteurs : Jibril FrejPhilippe MulhemDidier SchwabJean-Pierre Chevallet
• Organismes : Laboratoire d'Informatique de Grenoble Laboratoire d'Informatique de Grenoble Laboratoire d'Informatique de Grenoble Groupe d’Étude en Traduction Automatique/Traitement Automatisé des Langues et de la Parole Université Grenoble Alpes Laboratoire d'Informatique de Grenoble

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Résumé : Document indexing is a key component for efficient information retrieval (IR). After preprocessing steps such as stemming and stopword removal, document indexes usually store term-frequencies (tf). Along with tf (that only reflects the importance of a term in a document), traditional IR models use term discrimination values (TDVs) such as inverse document frequency (idf) to favor discriminative terms during retrieval. In this work, we propose to learn TDVs for document indexing with shallow neural networks that approximate traditional IR ranking functions such as TF-IDF and BM25. Our proposal outperforms, both in terms of nDCG and recall, traditional approaches, even with few positively labelled querydocument pairs as learning data. Our learned TDVs, when used to filter out terms of the vocabulary that have zero discrimination value, allow to both significantly lower the memory footprint of the inverted index and speed up the retrieval process (BM25 is up to 3 times faster), without degrading retrieval quality.

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Fichiers liés : SIGIR2020_for_HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/07/2020
• Auteurs : Anne MarmagneSophie JasinskiMathilde FagardLaurence BillPhilippe GuercheCéline Masclaux‐daubresseFabien Chardon
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans Journal of Experimental Botany le 25/10/2020

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Résumé : Nitrogen (N) is an essential nutrient that plants require for the synthesis of amino acids, proteins, and many other important metabolites. Plant metabolism and growth are consequently dependent on the amount of N that is assimilated and distributed from source leaves to developing sinks, such as fruits and seeds. The environmental stresses enhanced by climate change deeply influence seed yield and seed composition, and may disturb N use efficiency (NUE) in pants. We aimed to investigate plant responses to extreme climates with regard to NUE, N remobilization efficiency, and seed composition. By studying a collection of Arabidopsis genotypes showing a range of C:N ratios in seeds, we investigated the impact of different post-flowering growth conditions (control, heat, drought, low nitrate availability, induced senescence, and induced plant defense) on seed yield, N allocation in organs, NUE, and N remobilization efficiency. We analysed how post-flowering stresses could change seed filling and showed that post-flowering stresses change both the range of N and C concentrations and the C:N stoichiometry in seeds. Using a new trait, called delta seed composition, we measured the deviation in C:N stoichiometry of each genotype and revealed the genetic determinism of the C:N stoichiometry. Altogether, the results indicate that extreme climate impacts NUE dramatically in plants and generates different bottlenecks in N fluxes during seed filling.

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Fichiers liés : eraa011.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 24/07/2020
• Auteurs : Pierre-Yves DumasSarah BertoliEmilie BérardLaetitia LargeaudAudrey BidetEric DelabesseThibaut LeguayHarmony LeroyNoémie GadaudJean-Baptiste RieuJean-Philippe VialFrançois VergezNicolas LechevalierIsabelle LuquetEmilie KleinAudrey SarryAnne-Charlotte de GrandeArnaud PigneuxChristian Récher
• Organismes : Centre Hospitalier Universitaire de Bordeaux Biothérapies des maladies génétiques et cancers Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Universitaire de Toulouse Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Universitaire de Bordeaux Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Bordeaux Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Bordeaux Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Bordeaux Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Biothérapies des maladies génétiques et cancers Institut Universitaire du Cancer de Toulouse - Oncopole Centre Hospitalier Universitaire de Toulouse Centre de Recherches en Cancérologie de Toulouse
• Publié dans Cancers le 21/10/2020

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Résumé : Two recent phase 3 trials showed that outcomes for relapsed/refractory (R/R) FLT3-mutated acute myeloid leukemia (AML) patients may be improved by a single-agent tyrosine kinase inhibitor (TKI) (i.e., quizartinib or gilteritinib). In the current study, we retrospectively investigated the characteristics and real-world outcomes of R/R FLT3-internal tandem duplication (ITD) acute myeloid leukemia (AML) patients in the Toulouse-Bordeaux DATAML registry. In the study, we included 316 patients with FLT3-ITD AML that received intensive chemotherapy as a first-line treatment. The rate of complete remission (CR) or CR without hematological recovery (CRi) was 75.2%, and 160 patients were R/R after a first-line TKI-free treatment (n = 294). Within the subgroup of R/R patients that fulfilled the main criteria of the QUANTUM-R study, 48.9% received an intensive salvage regimen; none received hypomethylating agents or low-dose cytarabine. Among the R/R FLT3-ITD AML patients with CR1 durations < 6 months who received intensive TKI-free treatment, the rate of CR or CRi after salvage chemotherapy was 52.8%, and these results allowed a bridge to be transplanted in 39.6% of cases. Finally, in this QUANTUM-R standard arm-matched cohort, the median overall survival (OS) was 7.0 months and 1-, 3- and 5-year OS were 30.2%, 23.7% and 21.4%, respectively. To conclude, these real-world data show that the intensity of the second-line treatment likely affects response and transplantation rates. Furthermore, the results indicate that including patients with low-intensity regimens, such as low-dose cytarabine or hypomethylating agents, in the control arm of a phase 3 trial may be counterproductive and could compromise the results of the study.

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Fichiers liés : cancers-12-02044-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 24/07/2020
• Auteurs : Vincent GalandChristophe LeclercqHamed BourenaneStéphane BouléAndré VincentelliPhilippe MauryPierre MondolyFrançois PicardNicolas WeltéMichel KindoThomas CardiJean‐luc PasquiéPhilippe GaudardJean-Baptiste GourraudVincent ProbstPascal DefayeAude BoignardMarylou ParaVincent AlgalarrondoEdeline PelcéVlad GariboldiMatteo PozziJean‐françois ObadiaFrédéric AnselmePierre‐yves LitzlerKatrien BlanchartGerard BabatasiFabien GarnierMarie BielefeldDavid HamonNicolas LelloucheThierry BourguignonBertrand PierreRomain EschalierNicolas D’ostrevyEmilie VarletEloi MarijonHugues BlangyNicolas SadoulErwan FlécherRaphaël P Martins
• Organismes : IMRB - SMCD/"Senescence, Metabolism and Cardiovascular Diseases" [Créteil]
• Publié dans PACE - Pacing and Clinical Electrophysiology le 02/11/2020

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Résumé : Abstract Background Implantable cardioverter‐defibrillator (ICD) lead dysfunction has been reported after left ventricular assist device (LVAD) implantation in limited single‐center studies. We aimed at describing and characterizing the incidence of ICD lead parameters dysfunction after LVAD implantation. Methods Among the 652 patients enrolled in the ASSIST‐ICD study, only patients with an ICD prior to LVAD were included (n = 401). ICD lead parameters dysfunction following LVAD implantation is defined as follows: (a) >50% decrease in sensing threshold, (b) pacing lead impedance increase/decrease by >100Ω, and (c) >50% increase in pacing threshold. Results One hundred twenty‐two patients with an ICD prior to LVAD had available ICD interrogation reports prior and after LVAD. A total of 67 (55%) patients exhibited at least one significant lead dysfunction: 17 (15%) exhibited >50% decrease in right ventricular (RV) sensing, 51 (42%) had >100 Ω increase/decrease in RV pacing impedance, and 24 (20%) experienced >50% increase in RV pacing threshold. A total of 52 patients experienced ventricular arrhythmia during follow‐up and all were successfully detected and treated by the device. All lead dysfunction could be managed conservatively. Conclusion More than 50% of LVAD‐recipients may experience >1 significant change in lead parameters but none had severe clinical consequences.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2020
• Auteurs : Sean M BagshawRon WaldNeill K J AdhikariRinaldo BellomoBruno R Da CostaDidier DreyfussBin DuMartin P GallagherStéphane GaudryEric A HosteFrançois LamontagneMichael JoannidisGiovanni LandoniKathleen D LiuDaniel F McauleyShay P McguinnessJavier A NeyraAlistair D NicholMarlies OstermannPaul M PalevskyVille PettiläJean-Pierre QuenotHaibo QiuBram RochwergAntoine G SchneiderOrla M SmithFernando ThoméKevin E ThorpeSuvi VaaraMatthew WeirAmanda Y WangPaul YoungAlexander ZarbockRinaldo BellomoGlenn M EastwoodLeah PeckHelen YoungPeter KrugerGordon LaurieEmma SaylorJason MeyerEllen VenzKrista WetzigCraig FrenchForbes McgainJohn MulderGerard FennessySathyajith KoottayiSamantha BatesMiriam TownsRebecca MorganAnna TippettAndrew UdyChris MasonElisa LicariDashiell GantnerJason McclureAlistair NicholPhoebe MccrackenJasmin BoardEmma MartinShirley VallanceMeredith YoungChelsey VladicSteve McgloughlinDavid GattasHeidi BuhrJennifer ColesDebra HutchJames WunLouise ColeChristina WhiteheadJulie LowreyKristy MastersRebecca GreshamVictoria CampbellDavid GutierrezJane BrailsfordLoretta ForbesLauren MurrayTeena MaguireMartina NichonghaileNeil OrfordAllison BoneTania ElderkinTania SalernoTim ChimundaJason FletcherEmma BroadfieldSanjay PorwalCameron KnottCatherine BoschertJulie SmithAngus RichardsonDianne HillGraeme DukePeter OziemskiSantiago CegarraPeter ChanDeborah WelshStephanie HunterOwen RoodenburgJohn DyettNicos KokotsisMax MoserYang YangLaven PadayacheeJoseph VetroHimangsu GangopadhyayMelissa KaufmanAngaj GhoshSimone SaidAlpesh PatelShailesh BihariElisha MathesonXia JinTapaswi ShresthaKate SchwartzMartin P GallagherRosalba CrossWinston CheungHelen WongMark KolAsim ShahAmanda Y WangCelia BradfordPierre JaninSimon FinferNaomi DielJonathan GatwardNaomi HammondAnthony DelaneyFrances BassElizabeth YaradHergen BuscherClaire ReynoldsNerilee BakerMichael JoannidisRomuald BellmannAndreas PeerJulia HasslacherPaul KoglbergerSebastian KleinKlemens ZotterAnna BrandtnerArmin FinkenstedtAdelheid DitlbacherFrank HartigDietmar FriesMirjam BachlerBettina SchenkMartin WagnerPhilipp EllerThomas StaudingerEsther TillerPeter SchellongowskiAndja BojicEric A HosteStephanie BrackeLuc De CropDaisy VermeirenFernando ThomeBianca ChiellaLucia FendtVeronica AntunesJean-Philippe LafranceFrançois LamontagneFrédérick d'AragonCharles St-ArnaudMichael MayetteÉlaine CarbonnaeuJoannie MarchandMarie-Hélène MasseMarilène LadouceurAlexis F TurgeonFrançois LauzierDavid BellemareCharles Langis FrancoeurGuillaume LeblancGabrielle GuilbaultStéphanie GrenierEve CloutierAnnick BoivinCharles Delisle-ThibaultPanagiota GiannakourosOlivier CosterousseJean-François CailhierFrançois-Martin CarrierAli GhamraouiMartine LebrasseurFatna BenettaibMaya SalaméDounia BoumahniYing Tung SiaJean-François NaudIsabelle RoyBraden J MannsShelley DugganDominic CarneyJennifer BarchardRichard P WhitlockEmilie Belley-CoteNevena SavijaAlexandra SabevTroy CampbellThais CrearyKelson DevereauxShira BrodutchClaudio RigattoBojan PaunovicOwen MooneyAnna GlybinaOksana HarasemiwMichelle Di NellaJohn HarmonNavdeep MehtaLouis LakatosNicole HaslamFrancois LelloucheMathieu SimonYing TungPatricia LizottePierre-Alexandre BourchardBram RochwergTim KarachiTina MillenJohn MuscedereDavid MasloveJ Gordon BoydStephanie SibleyJohn DroverMiranda HuntIlinca GeorgescuRandy WaxIlan LengaKavita SridharAndrew SteeleKelly FuscoTaneera GhateMichael TolibasHolly RobinsonMatthew A WeirRavi TanejaIan M BallAmit GargEileen CampbellAthena OvsenekSean M BagshawSean Van DiepenNadia BaigSheldon MagderHan YaoAhsan AlamJosie CampisiErika MacintyreElla RokoshKimberly ScherrStephen LapinskySangeeta MehtaSumesh ShahDaniel J NivenHenry T StelfoxStacey RuddellMichael RussellKym JimGillian BrownKerry OxtobyAdam HallLuc BenoitColleen SokolowskiBhanu PrasadShelley GiebelDemetrios J KutsogiannisPatricia ThompsonTayne ThompsonRobert CironeKanthi KavikondalaMark SothFrance ClarkeAlyson TakaokaRon WaldDavid MazerKaren BurnsJan FriedrichDavid KleinGyan SandhuMarlene SantosImrana KhalidJennifer HodderPeter DodekNajib AyasVictoria AlcuazGabriel SuenOleksa RewaGurmeet SinghSean NorrisNeil GibsonCastro AriasAysha ShamiCeline PelletierNeill K J AdhikariAlireza ZahiriehAndre AmaralNicole MarinoffNavjot KaurAdic PerezJane WangGregory HaljanChristopher CondinLauralyn McintyreBrigette GomesRebecca PorteousIrene WatpoolSwapnil HiremathEdward ClarkMargaret S HerridgeFelicity BackhouseM Elizabeth WilcoxKarolina WalczakVincent KiAsheer SharmanMartin RomanoR T Noel GibneyAdam S RomanovskyLorena MccoshenGordon WoodDaniel OvakimFiona AuldGayle CarneyMeili DuanXiaojun JiDongchen GuoZhili QiJin LinMeng ZhangLei DongJingfeng LiuPei LiuDeyuan ZhiGuoqiang BaiYu QiuZiqi YangJing BaiZhuang LiuHaizhou ZhuangHaiman WangJian LiMengya ZhaoXiao ZhouXianqing ShiBaning YeManli LiuJing WuYongjian FuDali LongYu PanJinlong WangHuaxian MeiSongsong ZhangMingxiang WenEnyu YangSijie MuJianquan LiTingting HuBingyu QinMin LiCunzhen WangXin DongKaiwu WangHaibo WangJianxu YangBin DuChuanyao WangDongxin WangNan LiZhui YuSong XuLan YaoGuo HouZhou LiuLiping LuYingtao LianChunting WangJichen ZhangRuiqi DingGuoqing QiQizhi WangPeng WangZhaoli MengMan ChenXiaobo HuXiandi HeShibing ZhaoLele HangRui LiSuhui QinKun LuShijuan DunCheng LiuQi ZhouZhenzhen ChenJing MeiMinwei ZhangHao XuJincan LinQindong ShiLijuan FuQinjing ZengHongye MaJinqi YanLan GaoHongjuan LiuLei ZhangHao LiXiaona HeJingqun FanLitao GuoYu LiuXue WangJingjing SunZhongmin LiuJuan YangLili DingLulu ShengXingang LiuJie YanQuihui WangYifeng WangDan ZhaoShuangping ZhaoChenghuan HuJing LiFuxing DengHaibo QuiYi YangMin MoChun PanChangde WuYingzi HuangLili HuangAiran LiuVille PettiläSuvi T VaaraAnna-Maija KorhonenSanna TörnblomSari SutinenLeena PettiläJonna HeinonenEliria LappiTaria SuhonenSari KarlssonSanna HoppuVille JalkanenAnne KuitunenMarkus LevorantaJaakko LångsjöSanna RistimäkiKaisa MalilaAnna WoottenSimo VarilaMikko J JärvisaloOuti InkinenSatu KentalaKeijo LeivoPaivi HaltiaDidier DreyfussJean-Damien RicardJonathan MessikaAbirami TiagarajahMalo EmeryAline DechanetCoralie GernezDamien RouxLaurent Martin-LefevreMaud FiancetteIsabelle VinatierJean Claude LacheradeGwenhaël ColinChristine LebertMarie-Ange AzaisAihem YehiaCaroline PoupletMatthieu Henry-LagarrigueAmélie SeguinLaura CrosbyJulien MaizelDimitri Titeca-BeauportAlexandre DemouleJulien MayauxMartin DresElise MorawiecMaxens DecalveleSuela DemiriMorgane FaureClémence MariosMaxime MalletMarie Amélie OrdonLaura MorizotMarie CantienFrançois PoussetStéphane GaudryFlorent PoirsonYves CohenLaurent ArgaudMartin CourLaurent BitkerMarie SimonRomain HernuThomas BaudrySyvie de La SalleAdrien RobineNicholas SedillotXavier TchenioCamille BouisseSylvie RouchSaber Davide BarbarRémi TrussonFabienne TamionSteven GrangéDorothée CarpentierGuillaume ChevrelLuis Ensenyat-MartinSophie MarqueJean-Pierre QuenotPascal AndreuAuguste DargentAudrey LargeNicolas ChudeauMickael LandaisBenoit DerrienJean Christophe CallahanChristophe GuittonCharlène Le MoalAlain RobertKarim AsehnouneRaphael CinottiNicolas GrillotDominique DemeureChristophe VinsonneauImen RahmaniMehdi MarzoukThibault DekeyserCaroline SejourneMélanie VerlayFabienne TheveninLucie DelecolleDidier TheveninBertrand SouweineElisabeth CoupezMireille AddaJean-Pierre EraldiAntoine MarchalotNicolas de ProstArmand Mekontso DessapKeyvan RazaziFerhat MezianiJulie Boisrame-HelmsRaphaël Clere-JehlXavier DelabrancheChristine KummerlenHamid MerdjiAlexandra MonnierYannick RabouelHassene RahmaniHayat AllamSamir ChenafVincenta FranjaBertrand PonsMichel CarlesFrédéric MartinoRégine RichardBenjamin ZuberGuillaume LacaveKarim LakhalBertrand RozecHoa Dang VanÉric BouletFouad FadelCedric CleophaxNicolas DufourCaroline GrantMarie ThuongJean ReignierEmmanuel CanetLaurent NicoletThierry BoulainMai-Anh NayDalila BenzekriFrançois BarbierAnne BretagnolToufik KamelArmelle MathonnetGrégoire MullerMarie SkarzynskiJulie RossiAmandine PradetSandra Dos SantosAurore GueryLucie MullerLuis FelixJulien BohéGuillaume ThiéryNadia AissaouiDamien VimpereMorgane CommeureucJean-Luc DiehlEmmanuel GuerotAlain CombesAnia NieszkowskaPaul MasiOrfeas LiangosMonika WittigAlexander ZarbockMira KüllmarThomas Van WaegeninghNadine RosenowAlistair D NicholKathy BrickellPeter DoranPatrick T MurrayGiovanni LandoniRosalba LemboAlberto ZangrilloGiacomo MontiMargherita TozziMatteo MarzaroliGaetano LombardiGianluca PaternosterMichelangelo VitielloShay McguinnessRachael ParkeMagdalena ButlerEileen GilderKeri-Anne CowdreySamantha WallaceJane HallionMelissa WoolettPhilippa NealKarina DuffyStephanie LongColin McarthurCatherine SimmondsYan ChenRachael McconnochieLynette NewbyDavid KnightSeton HendersonJan MehrtensStacey MorganAnna MorrisKymbalee Vander HaydenTara BurkeMatthew BaileyRoss FreebairnLesley ChadwickPenelope ParkChristine RollsLiz ThomasUlrike BuehnerErin WilliamsJonathan AlbrettSimon KirkhamCarolyn JacksonTroy BrowneJennifer GoodsonDavid JacksonJames HoughtonOwen CallenderVicki HigsonOwen KeetClive DominyPaul YoungAnna HuntHarriet JuddCassie LawrenceShaanti OlatunjiYvonne RobertsonCharlotte Latimer-BellDeborah HendryAgnes Mckay-VucagoNina BeehreEden LesonaLeanlove NavarraChelsea RobinsonRyan JangAndrea JungeBridget LambertAntoine G SchneiderMichel ThibaultPhilippe EckertSébastien KisslingErietta PolychronopoulosElettra PoliMarco AltarelliMadeleine SchnorfSamia Abed MallairdClaudia HeideggerAurelie PerretPhilippe MontillierFrederic SanglaSeigenthaller NeilsAude De WattevilleMandeep-Kaur PhullAparna GeorgeNauman HussainTatiana PogrebanSteve LobazAlison DanielsMishell CunninghamDeborah KerrAlice NicholsonPradeep ShanmugasundaramJudith AbramsKatarina MansoGeraldine HambrookElizabeth MckerrowJuvy SalvaStephen FoulkesMatthew WiseMatt MorganJenny BrooksJade ColeTracy Michelle DaviesHelen HillEmma ThomasMarcela VizcaychipiBehrad BaharloJaime CarungcongPatricia CostaLaura MartinsRitoo KapoorTracy HazeltonAngela MoonJanine MusselwhiteBen ShelleyPhilip MccallMarlies OstermannGill ArbaneAneta BociekMartina MarottiRosario LimSara CamposNeus Grau NovellasArmando CennamoAndrew SlackDuncan WyncollLuigi CamporotaSimon SparkesRosalinde TilleyAustin RattrayGayle MorelandJane DuffyElizabeth McgonigalPhilip HopkinsClare FinneyJohn SmithHarriet NobleHayley WatsonClaire-Louise HarrisEmma ClareyEleanor CorcoranJames BeckClare HowcroftNora YoungsElizabeth WilbyBethan OggAdam WolversonSandra LeeSusie ButlerMaryanne OkubanjoJulia HindleIngeborg WeltersKaren WilliamsEmily JohnsonJulie Patrick-HeseltonDavid ShawVictoria WaughRichard StewartEsther MwauraLynn WrenLouise MewSara-Beth SutherlandJane AdderleyJim RuddyMargaret HarkinsCallum KayeTeresa ScottWendy MitchellFelicity AndersonFiona WilloxVijay JagannathanMichele ClarkSarah PurvAndrew SharmanMegan MeredithLucy RyanLouise ConnerCecilia PetersDan HarveyAshraf RoshdyAmy CollinsMalcolm SimSteven HendersonNigel CheeSally PittsKatie BowmanMaria DilawershahLuke VamplewElizabeth HowePaula RogersClara HernandezClara PrendergastJane BentonAlex RosenbergLui G ForniAlice GrantPaula CarvelliAjay RaithathaSarah BirdMax RichardsonMatthew NeedhamClaire HirstJonathan BallSusannah LeaverLuisa HowlettCarlos Castro DelgadoSarah Farnell-WardHelen FarrahGeraldine GrayGipsy JosephFrancesca RobinsonAscanio TridenteClare HarropKaren ShukerDerek MclaughlanJudith RamseySharon MeehanBernd Oliver RoseRosie Reece-AnthonyBabita GurungTony WhitehouseCatherine SnelsonTonny VeenithAndy JohnstonLauren CooperRon CarreraKaren EllisEmma FellowsSamanth HarkettColin BerginElaine SpruceLiesl DespyStephanie GoundryNatalie DooleyTracy MasonAmy ClarkGemma DignamGeraldine WardBen AttwoodPenny ParsonsSophie MasonMichael MargarsonJenny LordPhilip McgloneLuke E HodgsonIndra ChadbournRaquel GomezJordi MargalefRinus PretoriusAlexandra HamshereJoseph CarterHazel CahillLia GraingerKate HowardGreg ForshawZoe GuyKianoush B KashaniRobert C Albright JrAmy AmsbaughAnita StoltenbergAlexander S NivenMatthew LynchAnnmarie O'MaraSyed NaeemSairah SharifJoyce Mckenney GoulartAshita TolwaniClaretha LyasLaura LattaAzra BihoracHaleh HashemighouchaniPhilip EfronMatthew RuppertJulie CupkaSean KileyJoshua CarsonPeggy WhiteGeorge OmalaySherry BrownLaura VelezAlina MarceronJavier A NeyraJuan Carlos AycinenaMadona EliasVictor M Ortiz-SorianoCaroline HauschildRobert Dorfman
• Organismes : Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517
• Publié dans New England Journal of Medicine le 29/10/2020

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Résumé : Background: Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain. Methods: We conducted a multinational, randomized, controlled trial involving critically ill patients with severe acute kidney injury. Patients were randomly assigned to receive an accelerated strategy of renal-replacement therapy (in which therapy was initiated within 12 hours after the patient had met eligibility criteria) or a standard strategy (in which renal-replacement therapy was discouraged unless conventional indications developed or acute kidney injury persisted for >72 hours). The primary outcome was death from any cause at 90 days. Results: Of the 3019 patients who had undergone randomization, 2927 (97.0%) were included in the modified intention-to-treat analysis (1465 in the accelerated-strategy group and 1462 in the standard-strategy group). Of these patients, renal-replacement therapy was performed in 1418 (96.8%) in the accelerated-strategy group and in 903 (61.8%) in the standard-strategy group. At 90 days, death had occurred in 643 patients (43.9%) in the accelerated-strategy group and in 639 (43.7%) in the standard-strategy group (relative risk, 1.00; 95% confidence interval [CI], 0.93 to 1.09; P = 0.92). Among survivors at 90 days, continued dependence on renal-replacement therapy was confirmed in 85 of 814 patients (10.4%) in the accelerated-strategy group and in 49 of 815 patients (6.0%) in the standard-strategy group (relative risk, 1.74; 95% CI, 1.24 to 2.43). Adverse events occurred in 346 of 1503 patients (23.0%) in the accelerated-strategy group and in 245 of 1489 patients (16.5%) in the standard-strategy group (P<0.001). Conclusions: Among critically ill patients with acute kidney injury, an accelerated renal-replacement strategy was not associated with a lower risk of death at 90 days than a standard strategy. (Funded by the Canadian Institutes of Health Research and others; STARRT-AKI ClinicalTrials.gov number, NCT02568722.).

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• Type de publi. : Rapport
• Date de publi. : 15/07/2020
• Auteurs : Jean-Louis J.L. PeyraudJoël AubinMarc BarbierRené BaumontCécile BerriJean Pierre BidanelChristine CittiCorinne CotinotChristian DucrotPierre P. DuprazPhilippe FaverdinNicolas N.C. FriggensSabine HouotMarie-Odile Nozières-PetitClaire Rogel GaillardVéronique Santé-Lhoutellier
• Organismes : Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] Sol Agro et hydrosystème Spatialisation Laboratoire Interdisciplinaire Sciences, Innovations, Sociétés Unité Mixte de Recherche sur les Herbivores - UMR 1213 Biologie des Oiseaux et Aviculture Génétique Animale et Biologie Intégrative Interactions hôtes-agents pathogènes [Toulouse] Biologie de la Reproduction, Environnement, Epigénétique & Développement Animal, Santé, Territoires, Risques et Ecosystèmes Structures et Marché Agricoles, Ressources et Territoires Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] Modélisation Systémique Appliquée aux Ruminants Ecologie fonctionnelle et écotoxicologie des agroécosystèmes Systèmes d'élevage méditerranéens et tropicaux Génétique Animale et Biologie Intégrative Qualité des Produits Animaux

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Résumé : L’ambition de l’Atelier de Réflexion Prospective sur l’élevage a été de repenser la place, les rôles de l’élevage et en quoi il doit se transformer pour contribuer pleinement au développement de systèmes agri-alimentaires plus durables ainsi que d’identifier des thématiques de recherches interdisciplinaires permettant d’explorer des fronts de science ou méthodologiques porteurs d’avenir pour lever les verrous de connaissances. La réflexion a été animée par un groupe de 15 chercheurs et a mobilisé une centaine de chercheurs. A partir d’une analyse du contexte et des drivers d’évolution des systèmes nous proposons un nouveau cadre conceptuel et des voies de progrès pour penser l’élevage de demain. L’élevage doit s’inscrire dans le cadre de systèmes agri-alimentaires circulaires dans lesquels il doit contribuer, au-delà d’une efficience accrue des moyens de production, à la préservation de la qualité des ressources et à la production d’une alimentation à un prix abordable. Il faut repenser les systèmes pour qu’ils soient climato-intelligents et répondent aux enjeux de santé et du bien-être des animaux et des hommes ; repenser les liens entre élevage, production végétale et territoire pour maximiser les recyclages et repenser les liens entre élevage, transformation et consommation de ces produits de l’élevage. Les innovations doivent être basées sur les principes de l’agro-écologie complétés par ceux de l’économie circulaire et par la mobilisation des leviers des (bio)technologies et de l’innovation organisationnelle. Le texte décrit quatre grandes priorités scientifiques avec leurs enjeux de recherche et produit des recommandations pour un plan d’action.

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Fichiers liés : Prospective Elevage RAPPORT synthèse-VF3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2020
• Auteurs : Violaine GuérinPierre LévyJean Louis ThomasThierry LardenoisPhilippe LacrosseEmmanuel SarrazinNatacha Regensberg De AndreisMartine Wonner
• Organismes : Collectif Laissons Les Médecins Prescrire, France. Institut Pierre Louis d'Epidémiologie et de Santé Publique Collectif Laissons Les Médecins Prescrire, France. Collectif Laissons Les Médecins Prescrire, France. Collectif Laissons Les Médecins Prescrire, France. Collectif Laissons Les Médecins Prescrire, France. Collectif Laissons Les Médecins Prescrire, France. Collectif Laissons Les Médecins Prescrire, France.
• Publié dans Asian Journal of Medicine and Health le 23/08/2023

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Résumé : Aims: The challenge regarding COVID-19 is to prevent complications and fatal evolution. Azithromycin (AZM) and hydroxychloroquine (HCQ) have proven their antiviral effect in vitro. We aimed to assess the efficacy and safety of AZM alone or combined to HCQ, prescribed, at an early stage, in patients with Covid-19, in a primary care setting. Study Design: Retrospective observational study. Place and Duration of Study: Patients have been followed by private practitioners in France, between March and April 2020. Methodology: Eighty-eight patients received either no or a symptomatic treatment (NST) (n=34) or AZM alone (n=34) or AZM+HCQ (n=20). The efficacy end point was the time to clinical recovery and the safety end point was the occurrence of cardiovascular events. To improve the evidence level, a case-control analysis was performed on a sample of 57 patients (19/group) matched for age, sex and BMI. Results: The mean (SD) times to achieve clinical recovery were respectively 25.8 days (11.1), 12.9 days (13.4) and 9.2 days (9.3), showing a statistically significant difference between NST and AZM alone (p<0.0001) or AZM+HCQ (p<0.0001). The statistical difference between NST and AZM was confirmed (p=0.0149) as well as the difference with AZM+HCQ (p=0.0002). No cardiac toxicity was recorded in any patient. No statistical difference was shown between AZM and AZM+HCQ groups, although the dual therapy tended to be more effective in patients over 50 years, based on an analysis using the cox model. Conclusion: AZM and AZM+HCQ favourably impacted the course of the disease. We need trials, ideally prospective/double blind, to show if a statistical difference can be evidenced with a broader group, and clarify the indications of each treatment depending on initial clinical presentation.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/07/2020
• Auteurs : Pablo Simón MarquésJosé María Andrés CastánPierre JosseMartin BlaisAmir Hossein HabibiIvan RamirezKarsten WalzerJean RoncaliPhilippe BlanchardClément Cabanetos
• Organismes : MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou MOLTECH-Anjou
• Publié dans New Journal of Chemistry le 01/11/2020

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Résumé : The synthesis of two N , N -bis(4-biphenylyl)aniline (BPA) based push–pull is reported herein. Evaluation as donor materials in all-small-molecule planar-heterojunction organic solar cells lead to impressive fill factor (>73%) and promising power conversion efficiencies.

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Fichiers liés : MS_NJC_BPA.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 12/07/2020
• Auteurs : Delphine JullienJ.C. DupréFranck HesserLuca UzielliRiparbelli LorenzoPaola MazzantiCécilia GauvinJoseph GrilGilles TournillonPhilippe Hazael-MassieuxDanièle AmorosoPierre StepanoffMarina Bousvarou
• Organismes : Bois Institut Pprime [UPR 3346] Institut Pprime [UPR 3346] Department of Agriculture, Food, Environment and Forestry Department of Agriculture, Food, Environment and Forestry Department of Agriculture, Food, Environment and Forestry Science and Mechanichs in Conservation and Heritage [Entreprise de promotion des études mécaniques pour le patrimoine] Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Atelier Tournillon Atelier Amoroso Waldeis Atelier Amoroso Waldeis Musée Fabre [Montpellier] Musée Fabre [Montpellier]

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• Type de publi. : Article dans une revue
• Date de publi. : 11/07/2020
• Auteurs : Michel ZeitouniPierre SabouretMathieu KerneïsJohanne SilvainJean-Philippe ColletÉric BruckertGilles Montalescot
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans European Heart Journal - Cardiovascular Pharmacotherapy le 31/10/2019

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Résumé : In 2019, the European Society of Cardiology and European Atherosclerosis Society released a new guideline document with substantial changes regarding the assessment of cardiovascular risk and treatments. The update of high-risk criteria and categories led to a better detection and primary prevention of patients at risk of a first cardiovascular event. Nonetheless, additional efforts are needed for a better inclusion of risk modifiers, especially specific to women, to improve risk stratification and direct primary prevention. Eventually, we discuss how these new guidelines implement PCSK9 inhibitors for very-high risk individuals and the evidence supporting new LDL-C goals below such as 55 mg/dL and 40 mg/dL.

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