Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Cindy OrvainYea-Lih LinFrancette Jean-LouisHakim HociniBarbara HersantYamina BennasserNicolas OrtonneClaire HotzPierre WolkensteinMichele BoniottoPascaline TisserandCécile LefebvreJean-Daniel LelièvreMonsef BenkiranePhilippe PaseroYves LévySophie Hüe
• Organismes : Vaccine Research Institute [Créteil, France]
• Publié dans Journal of Clinical Investigation le 24/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Cindy OrvainYea-Lih LinFrancette Jean-LouisHakim HociniBarbara HersantYamina BennasserNicolas OrtonneClaire HotzPierre WolkensteinMichele BoniottoPascaline TisserandCécile LefebvreJean-Daniel LelièvreMonsef BenkiranePhilippe PaseroYves LévySophie Hüe
• Organismes : Vaccine Research Institute [Créteil, France] Institut de génétique humaine Immunologie, dermatologie, oncologie ; Oncodermatologie, immunologie et cellules souches cutanées Université Sorbonne Paris Cité Vaccine Research Institute [Créteil, France] Hôpital Henri Mondor Institut de génétique humaine Institut Mondor de Recherche Biomédicale Hôpital Albert Chenevier Hôpital Henri Mondor CHU Henri Mondor [Créteil] Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Vaccine Research Institute [Créteil, France] Vaccine Research Institute [Créteil, France] Institut de génétique humaine Institut de génétique humaine Hôpital Henri Mondor Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor
• Publié dans Journal of Clinical Investigation le 24/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Solène GérardMerwan MokhtariJean-Pierre LandesmanChristophe LevalloisMarc FouchierErwine PargonPhilippe Pagnod-RossiauxFrancois LaruelleAlain MoréacBrahim AhammouDaniel T Cassidy
• Organismes : Institut de Physique de Rennes Institut de Physique de Rennes Institut de Physique de Rennes Institut des Fonctions Optiques pour les Technologies de l'informatiON Laboratoire des technologies de la microélectronique Laboratoire des technologies de la microélectronique 3SP Technologies 3SP Technologies Institut de Physique de Rennes Institut de Physique de Rennes McMaster University [Hamilton, Ontario]
• Publié dans Thin Solid Films le 22/10/2020

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Résumé : We measured details of the strain/stress fields produced in GaAs(100) and InP(100) substrates by the presence of narrow dielectric stripes processed from thin films obtained by plasma-enhanced chemical vapor deposition with a residual and controlled built-in compressive or tensile stress. Micro-photoluminescence techniques were used, measuring either the spectral shift of the luminescence peak or the degree of polarization (DOP) of the spectrally integrated signal. These techniques provide information on different parts of the strain tensor (isotropic and anisotropic). The anisotropic deformation was found to change with the magnitude and sign of the initial built-in stress, and also with the stripe width. Using an analytical model, we were able to determine accurately several physical parameters which describe the stress/strain situation. The localized stress at the edges, expressed within an edge force concept, is shown to follow the expected initial built-in stress and also a stress reduction when the stripe width is decreased. This is interpreted as an evidence of some strain relaxation occurring near the stripe edges. This relaxation also impacts the shape of the DOP curves near the edges. The other important conclusion is the observation that the strain does not return to an isotropic situation (as in the case of an infinite thin film) in the central part of the stripes, even if the widths of these stripes are large (100 μm). The analytical model is developed and explained step-by-step. This analytical model produces quantitative data that describe the different effects observed. These data can be very helpful in the design and optimization of photonic devices when the photo-elastic effect can be significant, such as waveguides. The μPL measurements coupled with the model can also provide feedback to allow better control of the processing of such thin film devices.

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Fichiers liés : Gérard et al-2020-Photoluminescence mapping of the strain induced in InP and GaAs substrates by.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Thi Huong Levan Quyen NguyenG. Trippé-AllardPierre BléteauMathieu BastideSarra Gam-DerouichRoméo BonnetJean-Christophe LacroixUshula TefashePascal MartinMaria Luisa Della RoccaFrederic LafoletPhilippe LafargeRichard Mccreery
• Organismes : Interfaces, Traitements, Organisation et Dynamique des Systèmes Interfaces, Traitements, Organisation et Dynamique des Systèmes Interfaces, Traitements, Organisation et Dynamique des Systèmes Interfaces, Traitements, Organisation et Dynamique des Systèmes Laboratoire Matériaux et Phénomènes Quantiques University of Alberta
• Publié dans Advanced Electronic Materials le 22/10/2020

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Résumé : The control of the interface and the adhesion process are key issues for the development of new application based on electrochromic materials. In this work the functionalization of an electrode’s surface through electroreduction of diazonium generated in situ from 4-(2,5-di-thiophen-2-yl-pyrrol-1-yl)-phenylamine (SNS-An) has been proposed. The synthesis of the aniline derivative SNS-An was performed and the electrografting was investigated by cyclic voltammetry on various electrodes. Then the organic thin film was fully characterized by several techniques and XPS analysis confirms the presence of an organic film based on the chemical composition of the starting monomer and allows an estimation of its thickness confirmed by AFM scratching measurements. Depending on the number of electrodeposition cycles, the thickness varies from 2 nm to 10 nm, which corresponds to a few grafted oligomers. In addition, the grafted film showed a good electrochemical stability depending on the scan rates up to 400 V/s and the electrochemical response of the modified electrode towards several redox probes showed that the attached layer acts as a conductive switch. Therefore, the electrode behaves as a barrier to electron transfer when the standard redox potential of the probe is below the layer switching potential, whereas the layer can be considered as transparent towards the electron transfer for redox probes with a redox potential above it.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Basile KerlerouxThibault FabacherNicolas BricoutMartin MoïseBenoit TestudSivadji VingadassalomHéloïse IferganKévin JanotArturo ConsoliWagih Ben HassenEimad ShotarJulien OgnardGuillaume CharbonnierVincent L’allinecAlexis GuédonFederico BologniniGaultier MarnatGéraud ForestierAymeric RouchaudRaoul PopNicolas RaynaudFrançois ZhuJonathan CorteseVanessa ChalumeauJérôme BergeSimon EscalardGrégoire BoulouisCyril ChivotRiyad HanafiAnne PascoJean-Baptiste GirotAlessandra BiondiFortunato Di CaterinoPanagiotis PrimikirisGiovanni VitaleLouise BonnetFlorent GarielXavier BarreauSabrina DebruxellesLudovic LucasPatrice MenegonStéphane OlindoMathilde PoliPauline RenouSharmila SagnierIgor SibonLouis VeunacJean-Christophe GentricCharlotte BarbierMarion BoulangerJulien CogezSophie GuettierRomain SchneckenburgerEmmanuel TouzeMariette DelaitrePablo LebendinskyMariano MusacchioFrédéric RicolfiPierre ThouantFrançois CaparrosBarbara CasollaLucie Della SchiavaNelly DequatreHilde HenonMarco PasiApolline KazemiFouzi BalaLaurent EstradeCharbel MounayerSusanna SalemeFrancisco Macian-MontoroOmer EkerFrançois CottonKarine Blanc-LasserreSerkan CakmakTae-Hee ChoLaurent DerexAnne-Claire LukaszewiczLaura MechtouffNorbert NighoghossianFrédéric PhilippeauRoberto RivaFrancis TurjmanAnne-Evelyne ValletXavier CarlePhilippe Dory-LautrecAnthony ReyreJean-François HakHervé BrunelAmel BenaliFrançois-Louis CollemicheCyril DargazanliFrederico CagnazzoImad DerrazCaroline ArquizanLucas CortiVincent CostalatNicolas GaillardGrégory GascouPierre-Henri LefèvreIsabelle MourandCarlos RiquelmeAnne Laure DerelleBenjamin GoryLiang LiaoRomain TonneletRené AnxionnatMathieu BonnerotSerge BracardMarc BraunLisa HumbertjeanJean-Christophe LacourGioia MioneSophie PlanelSébastien RichardNolwenn Riou-ComteEmmanuelle SchmittRomain BourcierLili DetrazHubert DesalPierre-Louis AlexandreBenjamin Daumas-DuportCédric LenobleMonica RoyOghuzan CoskunFrederico Di MariaBertrand LapergueGeorges RodeschAdrien WangDavid Weisenburger-LileSergio ZimatoreNadia AjiliGéraldine BuardSerge EvrardLucas GorzaJulie GratieuxMorgan LeguenSylvie MarinierFernando PicoRoxanna PollHaja RakotoharinandrasanaPhilippe TassanMaya TchikviladzeFrançois DelvoyeSolène HebertRaphaël BlancGabriele CiccioJean-Philippe DesillesBenjamin MaierMikaël MazighiMichel P. PiotinHocine RedjemStanislas SmajdaMalek Ben MaachaOvide CorabianuThomas de BrouckerOlivier IlleEric ManchonMichael ObadiaMickael ObadiaIgor RaynouardRoxanne PeresCandice SabbenDidier SmadjaGuillaume TaylorLaurie-Anne ThionAugustin LeclerChristian DenierJildaz CaroffOlivier ChassinLaurent SpelleLaura VendittiArmand AymardJean BettyVittorio CivelliMichael EliezerMatteo FantoniEmmanuel HoudartMarc-Antoine LabeyrieJean-Pierre Saint MauriceErwah KalsoumAurelien PaciniChawkat RamadaneTitien TuilierAdrien VillainFrédéric ClarenconVincent DegosAhmed ElhfnawyMahmoud ElhoranyStéphanie LenckKevin PrematNader-Antoine SourourSonia AlamowitchFlore BaronnetSophie CrozierSandrine DeltourAnne LegerCharlotte RossoNadya PyatigorskayaChristine Rodriguez RegentDenis TrystramOlivier NaggaraPierre SenersGeorgios TsivgoulisMyriam EdjlaliRémi AgbononMohammed AlotaibiAntoine SonchetCatherine OppenheimJean François MederJoseph BenzakounLaurence LegrandCédric FauchéStéphane VelascoPierre François ManceauSebastien Solène Soize MoulinJean-Christophe FerréChristophe PayaFrançois EugèneJean-Yves GauvritSophie Langnier-LemercierMaria LassaleHelene RaoultThomas RonziereClément TracolStéphane VannierJulien BurelJulien Le MoalChrysanthi PapagiannakiMohamed AggourMarina SachetClaire BoutetRemy BeaujeuxAnca HasiuMonica ManisorDan MihocStéphane KremerCharles ArteagaSébastien GazzolaJean DarcourtChristophe CognardFabrice BonnevilleAnne Christine JanuelJean Marc OlivotNicolas RaposoAlain ViguierRichard BibiFakhreddine BoustiaDenis HerbreteauIgor Lima MaldonadoAna-Paula Narata
• Organismes : Service de neuroradiologie [Paris] Centre Hospitalier Universitaire [Strasbourg] Service de neuroradiologie [Lille] Service de neuroradiologie [Lille] Service de neuroradiologie diagnostique et interventionnelle Service de neuroradiologie diagnostique et interventionnelle Service de neuroradiologie [Tours] Service de neuroradiologie [Tours] Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch] Imagerie Adaptative Diagnostique et Interventionnelle Service de neuroradiologie [Paris] CHU Pitié-Salpêtrière [AP-HP] Service de Neuroradiologie [Brest] Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Universitaire d'Angers Hôpital Lariboisière-Fernand-Widal [APHP] Service de Neurologie [Hôpitaux Civils de Colmar] Département de Neuro-Radiologie [Bordeaux] Service de Neuroradiologie interventionnelle [CHU Limoges] Service de Neuroradiologie interventionnelle [CHU Limoges] Département de Neuroradiologie [Strasbourg] Service de neurologie [CHU de Poitiers] Imagerie Adaptative Diagnostique et Interventionnelle Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Service de Neuroradiologie [CHU de Bicêtre] Service de Neuroradiologie [CHU de Bicêtre] Département de Neuro-Radiologie [Bordeaux] CHU Rothschild [AP-HP] Service de neuroradiologie [Paris] Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Imagerie Adaptative Diagnostique et Interventionnelle Faculté de Médecine [Nancy]
• Publié dans Stroke le 31/10/2020

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Résumé : Background and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Secondary end points included care delays between onset, imaging, and groin puncture. To analyze the primary end point, we used a Poisson regression model. We then analyzed the correlation between the number of MTs and the number of COVID-19 cases hospitalizations, using the Pearson correlation coefficient (compared with the null value). Results: A total of 1513 patients were included at 32 centers, in all French administrative regions. There was a 21% significant decrease (0.79; [95%CI, 0.76–0.82]; P <0.001) in MT case volumes during the epidemic period, and a significant increase in delays between imaging and groin puncture, overall (mean 144.9±SD 86.8 minutes versus 126.2±70.9; P <0.001 in 2019) and in transferred patients (mean 182.6±SD 82.0 minutes versus 153.25±67; P <0.001). After the instatement of strict epidemic mitigation measures, there was a significant negative correlation between the number of hospitalizations for COVID and the number of MT cases ( R 2 −0.51; P =0.04). Patients treated during the COVID outbreak were less likely to receive intravenous thrombolysis and to have unwitnessed strokes (both P <0.05). Conclusions: Our study showed a significant decrease in patients treated with MTs during the first stages of the COVID epidemic in France and alarming indicators of lengthened care delays. These findings prompt immediate consideration of local and regional stroke networks preparedness in the varying contexts of COVID-19 pandemic evolution.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Zhimao WangJean-Luc Grosseau-PoussardBenoît PanicaudGuillaume GeandierPierre-Olivier RenaultPhilippe GoudeauNathalie BoudetNils BlancFelaniaina RakotovaoZhaojun Tao
• Organismes : Laboratoire des Systèmes Mécaniques et d'Ingénierie Simultanée Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Systèmes Mécaniques et d'Ingénierie Simultanée Institut Jean Lamour Surface, Interfaces et MAtériaux sous Contrainte [Institut Pprime] Surface, Interfaces et MAtériaux sous Contrainte [Institut Pprime] CRG & Grands instruments CRG & Grands instruments Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Systèmes Mécaniques et d'Ingénierie Simultanée
• Publié dans Computational Materials Science le 30/10/2020

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Résumé : Chromium-based alloys have been developed to form chromia layers in oxidizing environments for high temperature applications, providing a good protection against further oxidation. The mechanical behavior and oxide layer growth of yttria-coated or zirconium-doped Ni28Cr alloy are presently studied under high temperature oxidation conditions. These kind of reactive elements can decrease oxidation kinetics and significantly increase the adhesion of chromia layer on the metallic substrate. However, during oxidation, a compressive stress generally occurs in thermally grown oxide (TGO) due to the oxide layer and its mechanical interaction with the metallic substrate. These growth stresses, combined with the thermal stresses that develop during temperature changes, may initiate and cause layer cracking or spallation, which limits the lifetime of alloys in such a challenging environment. For prediction of this lifetime, it is important to know with accuracy the thermomechanical behavior of such a system. Therefore, a thermomechanical modelling is proposed and applied to optimize numerically the unknown parameters, especially viscoplastic ones. For the raw material and modified materials by reactive elements, the creep parameter decreases with a lower temperature, which means that the viscoplastic strain decreases with a decreasing temperature. For the yttria-coated or zirconium-doped material, the main result is an increase of the activation energy of this creep parameter with the quantity of reactive element.

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Fichiers liés : S0927025620301804.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Leila SellamiBenoit RuchetonImen Ben YounesAgnès CamuzatDario SaracinoDaisy RinaldiStéphane EpelbaumCarole AzuarRichard LevySophie AuriacombeDidier HannequinJérémie ParienteMathieu BarbierClaire Boutoleau-BretonnièrePhilippe CouratierFlorence PasquierVincent DeramecourtMathilde SauveeMarie SarazinJulien LagardeCarole Roué-JagotSylvie ForlaniLudmila JorneaIsabelle DavidEric LeguernBertrand DuboisAlexis BriceFabienne ClotFoudil LamariIsabelle Le Ber
• Organismes : Institut du Cerveau = Paris Brain Institute Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Centre Hospitalier Universitaire de Bordeaux Bordeaux population health Génétique médicale et fonctionnelle du cancer et des maladies neuropsychiatriques Toulouse NeuroImaging Center Département Neurologie [CHU Toulouse] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Service de neurologie [Nantes] Neuroépidémiologie Tropicale Service de Neurologie [CHU Limoges] Neuroendocrinologie et physiopathologie neuronale Pôle Psychiatrie et Neurologie [Grenoble] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Neurologie et thérapeutique expérimentale Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Neurologie et thérapeutique expérimentale Neurologie et thérapeutique expérimentale CHU Pitié-Salpêtrière [AP-HP] Neurologie et thérapeutique expérimentale
• Publié dans Neurobiology of Aging le 01/11/2020

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Résumé : GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinical phenotype, or disease progression in 160 GRN carriers. Importantly, progranulin levels were influenced by gender, with lower levels in male than in female patients in our study. Although we found no correlation with age at onset or with clinical phenotype, we confirmed that decreased level predicts GRN mutations, even in presymptomatic carriers more than four decades before disease onset. We also provided first evidence for the stability of levels throughout longitudinal trajectory in carriers, over a 4-year time span. Finally, we confirmed that progranulin levels constitute a reliable, cost-effective marker, suitable as a screening tool in patients with familial frontotemporal degeneration, and more broadly in patients without family history or with atypical presentations who are less likely to be referred for molecular diagnosis.

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Fichiers liés : S0197458020300476.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Orianne VillardDavid MorquinNicolas MolinariIsabelle RaingeardNicolas NagotJean-Paul CristolBoris JungCamille RoubilleVincent FoulongnePierre FeslerSylvain LamurePatrice TaourelAmadou KonateAlexandre Thibault Jacques MariaAlain MakinsonIvan BertchanskyR. LarcherKada KloucheVincent Le MoingEric RenardPhilippe Guilpain
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [Montpellier] Institut Montpelliérain Alexander Grothendieck Centre Hospitalier Régional Universitaire [Montpellier] CIC Montpellier Pathogénèse et contrôle des infections chroniques (PCCI) Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Département de Rhumatologie [Hôpital Lapeyronie - CHU Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Centre Hospitalier Régional Universitaire [Montpellier] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nîmes Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
• Publié dans Journal of Clinical Medicine le 29/10/2020

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Résumé : Background: The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect cells. Since the RAAS can induce and modulate pro-inflammatory responses, it could play a key role in the pathophysiology of Covid-19. Thus, we aimed to determine the levels of plasma renin and aldosterone as indicators of RAAS activation in a series of consecutively admitted patients for Covid-19 in our clinic.Methods: Plasma renin and aldosterone levels were measured, among the miscellaneous investigations needed for Covid-19 management, early after admission in our clinic. Disease severity was assessed using a seven-category ordinal scale. Primary outcome of interest was the severity of patients' clinical courses.Results: Forty-four patients were included. At inclusion, 12 patients had mild clinical status, 25 moderate clinical status and 7 severe clinical status. In univariate analyses, aldosterone and C-reactive protein (CRP) levels at inclusion were significantly higher in patients with severe clinical course as compared to those with mild or moderate course (p < 0.01 and p = 0.03, respectively). In multivariate analyses, only aldosterone and CRP levels remained positively associated with severity. We also observed a positive significant correlation between aldosterone and CRP levels among patients with an aldosterone level greater than 102.5 pmol/L.Conclusions: Both plasmatic aldosterone and CRP levels at inclusion are associated with the clinical course of Covid-19. Our findings may open new perspectives in the understanding of the possible role of RAAS for Covid-19 outcome.

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Fichiers liés : 2020 Villard et al., The Plasmatic.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Blanca Morales RodriguezAlejandro Domínguez-RodríguezJean-Pierre BenitahFlorence LefebvreThibaut MaraisNathalie MougenotPhilippe BeauvergerGisèle BonneVéronique BriandAna-María GómezAntoine Muchir
• Organismes : Centre de recherche en Myologie – U974 SU-INSERM Sanofi Aventis R&D [Chilly-Mazarin] Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Signalisation et physiopathologie cardiovasculaire Centre de recherche en Myologie – U974 SU-INSERM Phénotypage du petit animal Sanofi Aventis R&D [Chilly-Mazarin] Centre de recherche en Myologie – U974 SU-INSERM Sanofi Aventis R&D [Chilly-Mazarin] Signalisation et physiopathologie cardiovasculaire Centre de recherche en Myologie – U974 SU-INSERM
• Publié dans Biochemistry and Biophysics Reports le 28/10/2020

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Résumé : Cardiomyopathy caused by A-type lamins gene (LMNA) mutations (LMNA cardiomyopathy) is associated with dysfunction of the heart, often leading to heart failure. LMNA cardiomyopathy is highly penetrant with bad prognosis with no specific therapy available. Searching for alternative ways to halt the progression of LMNA cardiomyopathy, we studied the role of calcium homeostasis in the evolution of this disease. We showed that sarcolipin, an inhibitor of the sarco/endoplasmic reticulum (SR) Ca 2+ ATPase (SERCA) was abnormally elevated in the ventricular cardiomyocytes of mutated mice compared with wild type mice, leading to an alteration of calcium handling. This occurs early in the progression of the disease, when the left ventricular function was not altered. We further demonstrated that down regulation of sarcolipin using adeno-associated virus (AAV) 9mediated RNA interference delays cardiac dysfunction in mouse model of LMNA cardiomyopathy. These results showed a novel role for sarcolipin on calcium homeostasis in heart and open perspectives for future therapeutic interventions to LMNA cardiomyopathy.

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Fichiers liés : 1-s2.0-S2405580820300765-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2020
• Auteurs : Charles-Hugo MarquetteJacques BoutrosJonathan BenzaquenMarion FerreiraJean PastreChristophe PisonBernard PadovaniFaiza BettayebVincent FalletNicolas GuibertDamien BasilleMarius I. IlieVéronique HofmanPaul HofmanDominique Israël-BietFrançois ChabotAnne GuillaumotGaetan DesléeJeanne-Marie PerotinSandra DuryHervé MalArmelle MarceauRomain KesslerJean-Michel VergnonCarole PelissierFabrice Di PalmaAntoine CuvelierMaxime PatoutArnaud BourdinAnne Sophie GamezClaire AndréjakClaire PouletGéraldine FrançoisVincent JounieauxNicolas RocheStéphane JouneauGraziella BrinchaultPhilippe BonniaudAyoub ZouakArnaud ScherpereelSimon BaldacciAlexis CortotJean François MornexFrançois SteenhouwerSylvie LeroyJean-Philippe BerthetEric FontasJulie BulseiCoralie CruzelJohanna PradelliMaureen FontaineCharlotte ManielJennifer GriffonnetCatherine ButoriEric SelvaMichel PoudenxBernard AguilaniuGilbert FerretiFrançois ArbibAmandine BriaultAnne-Claire ToffartRaissa DahalaniMarie DestorsPascal ChanezLaurent GreillierPhilippe AstoulFabrice BarlésiJean-Yves GaubertJulien MazièresSylvain Marchand-AdamJacques CadranelNouha ChaabaneArmine IzadifarLise RosencherAnne-Marie RuppertThibault VieiraNathalie Mathiot
• Organismes : COMUE Université Côte d'Azur (2015-2019) Institut de Recherche sur le Cancer et le Vieillissement COMUE Université Côte d'Azur (2015-2019) Centre Hospitalier Régional Universitaire de Tours Hôpital Européen Georges Pompidou [APHP] Département de médecine aiguë spécialisée Centre Hospitalier Universitaire de Nice CHU Marseille CHU Tenon [AP-HP] Centre Hospitalier Universitaire de Toulouse CHU Amiens-Picardie Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 COMUE Université Côte d'Azur (2015-2019) COMUE Université Côte d'Azur (2015-2019) COMUE Université Côte d'Azur (2015-2019) Service de Pneumologie A, Centre de Compétences des Maladies Pulmonaires Rares, Centre Hospitalier Régional Universitaire de Nancy Service de Pneumologie [CHRU Nancy] Hôpital universitaire Robert Debré [Reims] Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Hôpital universitaire Robert Debré [Reims] APHP Service de Pneumologie B AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement Contraintes mécaniques et tissu osseux Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen] Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Département pneumologie et addictologie [Montpellier] Service de Pneumologie et Réanimation Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Université de Lorraine Service de Pneumologie et Réanimation Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Service de pneumologie Centre de Ressource et de Compétences de la Mucoviscidose [CHU Rennes] Lipides - Nutrition - Cancer [Dijon - U1231] Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 Site de Recherche Intégrée en Cancérologie Site de Recherche Intégrée en Cancérologie Centre Hospitalier Universitaire de Nice Service de chirurgie thoracique et cardio-vasculaire Hôpital Cimiez [Nice] Unité de Recherche Clinique en Economie de la Santé d'Ile-de-France Université Nice Sophia Antipolis - Faculté de Médecine Laboratoire de Neurosciences Cognitives [Marseille] Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Nice COMUE Université Côte d'Azur (2015-2019) HYLAB : Physiologie de l'exercice et interprétation clinique Clinique de pneumologie Université de Lorraine Institut d'oncologie/développement Albert Bonniot de Grenoble Université Grenoble Alpes - UFR Médecine Aix Marseille Université Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM] Division d'oncologie thoracique, Département des maladies pulmonaires Assistance Publique - Hôpitaux de Marseille Department of Radiology Service Pneumologie-Allergologie [CHU Toulouse] Centre d’Etude des Pathologies Respiratoires [Tours] Interactions cellulaires tumorales et leur environnement et réponse aux agents anti-cancéreux CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] Groupe de recherche clinique Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Résumé : Background Lung cancer screening with low-dose chest CT (LDCT) reduces the mortality of eligible individuals. Blood signatures might act as a standalone screening tool, refine the selection of patients at risk, or help to classify undetermined nodules detected on LDCT. We previously showed that circulating tumour cells (CTCs) could be detected, using the isolation by size of epithelial tumour cell technique (ISET), long before the cancer was diagnosed radiologically. We aimed to test whether CTCs could be used as a biomarker for lung cancer screening. Methods We did a prospective, multicentre, cohort study in 21 French university centres. Participants had to be eligible for lung cancer screening as per National Lung Screening Trial criteria and have chronic obstructive pulmonary disease with a fixed airflow limitation defined as post-bronchodilator FEV1/FVC ratio of less than 0∙7. Any cancer, other than basocellular skin carcinomas, detected within the previous 5 years was the main exclusion criterion. Participants had three screening rounds at 1-year intervals (T0 [baseline], T1, and T2), which involved LDCT, clinical examination, and a blood test for CTCs detection. Participants and investigators were masked to the results of CTC detection, and cytopathologists were masked to clinical and radiological findings. Our primary objective was to test the diagnostic performance of CTC detection using the ISET technique in lung cancer screening, compared with cancers diagnosed by final pathology, or follow up if pathology was unavailable as the gold standard. This study is registered with ClinicalTrials.gov identifier, number NCT02500693. Findings Between Oct 30, 2015, and Feb 2, 2017, we enrolled 614 participants, predominantly men (437 [71%]), aged 65∙1 years (SD 6∙5), and heavy smokers (52∙7 pack-years [SD 21∙5]). 81 (13%) participants dropped out between baseline and T1, and 56 (11%) did between T1 and T2. Nodules were detected on 178 (29%) of 614 baseline LDCTs. 19 participants (3%) were diagnosed with a prevalent lung cancer at T0 and 19 were diagnosed with incident lung cancer (15 (3%) of 533 at T1 and four (1%) of 477 at T2). Extrapulmonary cancers were diagnosed in 27 (4%) of participants. Overall 28 (2%) of 1187 blood samples were not analysable. At baseline, the sensitivity of CTC detection for lung cancer detection was 26∙3% (95% CI 11∙8–48∙8). ISET was unable to predict lung cancer or extrapulmonary cancer development.

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Fichiers liés : 2020 Marquette et al., Circulating.pdf

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