Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 12/06/2020
• Auteurs : Hugo DewitteSerena RizzoloPhilippe PailletPierre MagnanAlexandre Le RochFranck CorbiereRomain MolinaSylvain GirardTimothé AllancheCyprien MullerHortense DesjonqueresJean-Reynald MaceJean-Pierre BauduAlvaro Saravia FloresVincent Goiffon
• Organismes : Institut Supérieur de l'Aéronautique et de l'Espace Institut Supérieur de l'Aéronautique et de l'Espace DAM Île-de-France Institut Supérieur de l'Aéronautique et de l'Espace Institut Supérieur de l'Aéronautique et de l'Espace Institut Supérieur de l'Aéronautique et de l'Espace Institut Supérieur de l'Aéronautique et de l'Espace Laboratoire Hubert Curien Laboratoire Hubert Curien DAM Île-de-France Laboratoire d'expérimentations sur le comportement des équipements et la ventilation Orano OPTSYS Agence nationale pour le gestion des déchets radioactifs - ANDRA Institut Supérieur de l'Aéronautique et de l'Espace
• Publié dans IEEE Transactions on Nuclear Science le 31/10/2020

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Résumé : Capabilities of rad-hard electronics are often degraded by post-irradiation annealing, whose effects need to be considered in designing complex systems, such as CMOS image sensors (CISs). In particular, the commonly accepted behavior of annealing cannot be systematically assumed, because reverse annealing does not necessarily come from the degradation of the defects, but could be the result of defects annealing non-uniformities. This article provides an extensive study of the dark current and pixel readout electronic behavior of CISs during irradiation and annealing, in order to provide some insights on these annealing non-uniformities. The isochronal annealing performed up to 300 °C demonstrates that, up until a certain temperature, reverse annealing is almost always present, but the 300 °C annealing always heals the system very efficiently. When performed on specially designed gated pixels for ultrahigh dose applications, adding a N+ drain further mitigates the radiation effects along with the reverse annealing. This proves the efficiency of these rad-hard designs and calls for further research in this radiation-hardening direction.

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Fichiers liés : 0000171142_002.PDF

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• Type de publi. : Rapport
• Date de publi. : 12/06/2020
• Auteurs : Nelly DupinErwin DreyerSebastien CarpentierMathilde CausseSylvain DelzonChristian MeyerThierry AméglioPhilippe HintzingerPeter RogowskyMarie-Stéphane Tixier
• Organismes : Haut Conseil de l'Évaluation de la Recherche et de l'Enseignement Supérieur SILVA Biodiversity International Génétique et Amélioration des Fruits et Légumes Pluridisciplinarité au service de l’observation et de la recherche en environnement et astronomie Institut Jean-Pierre Bourgin - Sciences du végétal Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut Agro - Montpellier SupAgro

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Fichiers liés : a2021-ev-0342222f-der-pur210019567-029596-rf.pdf

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• Type de publi. :
• Date de publi. : 12/06/2020
• Auteurs : D B RoyDavid AldermanPauline AnastasiuMargarita ArianoutsouSylvie AugustinSven BacherCorina BaşnouJean-Nicolas BeiselSandro BertolinoFrançois BretagnolleLaura BonesiJean Louis ChapuisBruno ChauvelFrançois ChironPhilippe ClergeauJonathan CooperTeresa CunhaPinelopi DelipetrouMarie-Laure Desprez-LoustauMathieu DétaintSimon DevinViktoras DidžiulisFranz EsslBella S. GalilPiero GenovesiFrancesca GherardiStephan GollaschMartin HejdaPhilip E. HulmeMelanie JosefssonSalit KarkKaarina KauhalaMarc KenisStefan KlotzManuel KobeltIngolf KühnPhilip LambdonTor-Björn LarssonCarlos Lopez-VaamondeOlivier LorvelecHélia MarchanteDan MinchinWolfgang NentwigAnna Occhipinti-AmbrogiSergej OleninIrina OleninaIrina OvcharenkoVadim PanovMichel PascalJan PerglIrena PerglováJoan PinoPetr PyšekWolfgang RabitschJean-Yves RasplusBiren RathodAlain RoquesHelen RoyDaniel SauvardRiccardo ScaleraTamara A. ShiganovaSusan ShirleyAssaf ShwartzWojciech SolarzMontserrat VilàMarten WinterPierre YésouAnastasija ZaikoTim AdriaensPeter DesmetLien Reyserhove
• Organismes : Centre for Ecology and Hydrology Centre for Environment, Fisheries and Aquaculture Science [Weymouth] University of Bucharest National and Kapodistrian University of Athens Zoologie forestière Université de Fribourg = University of Fribourg Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona Laboratoire Interdisciplinaire des Environnements Continentaux Università degli studi di Torino = University of Turin DIVAPRA- Entomologia e Zoologia applicate all'ambiente Muséum national d'Histoire naturelle Università degli studi di Trieste = University of Trieste Muséum national d'Histoire naturelle Agroécologie [Dijon] The Hebrew University of Jerusalem Centre d'Ecologie et des Sciences de la COnservation Centre for Ecology and Hydrology European Commission - DG Research and Innovation National and Kapodistrian University of Athens Biodiversité, Gènes & Communautés Association Cistude Nature Laboratoire Interdisciplinaire des Environnements Continentaux Klaipėda University [Lituanie] Coastal Research and Planning Institute Universität Wien = University of Vienna Israel Oceanographic and Limnological Research National Institute for Environmental Protection and Research International Union for Conservation of Nature Invasive Species Specialist Group (ISSG) Dipartimento di Biologia Evoluzionistica 'Leo Pardi' GoConsult Institute of Botany of the Czech Academy of Sciences Lincoln University [Nouvelle-Zélande] Swedish Environmental Protection Agency The Hebrew University of Jerusalem Natural Resources Institute Finland Centre for Agricultural and Biosciences International Europe - Switzerland Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research Universität Bern = University of Bern = Université de Berne Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research Royal Society for the Protection of Birds European Environment Agency Zoologie forestière Ecologie, Société et Evolution (ex-Ecologie, Systématique et Evolution) Centre for Functional ecology Marine Organism Investigations Universität Bern = University of Bern = Université de Berne Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie] Klaipėda University [Lituanie] Coastal Research and Planning Institute Klaipėda University [Lituanie] Coastal Research and Planning Institute Klaipėda University [Lituanie] Coastal Research and Planning Institute St Petersburg State University INRA Rennes Institute of Botany of the Czech Academy of Sciences Institute of Botany of the Czech Academy of Sciences Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona Institute of Botany of the Czech Academy of Sciences Department of Biodiversity and Nature Conservation Centre de Biologie pour la Gestion des Populations Centre for Ecology and Hydrology Zoologie forestière Centre for Ecology and Hydrology Zoologie forestière International Union for Conservation of Nature SSC Invasive Species Specialist Group P.P. Shirshov Institute of Oceanology Oregon State University The Hebrew University of Jerusalem Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences Institute of Nature Conservation Estación Biológica de Doñana Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research Office national de la chasse et de la faune sauvage Klaipėda University [Lituanie] Coastal Research and Planning Institute Research Institute for Nature and Forest Research Institute for Nature and Forest Research Institute for Nature and Forest

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Résumé : The DAISIE - inventory of alien invasive species in Europe is a species checklist dataset published by the Research Institute for Nature and Forest (INBO) and the Centre for Ecology and Hydrology (CEH). It contains information on 12,104 taxa (mostly species and mostly introduced) occurring in the wild in Europe since 1500. It covers a broad taxonomic spectrum of terrestrial and aquatic free living and parasitic organisms. The collation of the alien species list is the result of the efforts of the DAISIE (http://www.europe-aliens.org) project partners and more than 300 collaborators from Europe and neighbouring countries, involved in different fields of expertise and organisations. Here the DAISIE checklist is published as a standardized Darwin Core Archive and includes for each species: the scientific name, higher classification, and stable taxon identifier (in the taxon core), the vernacular names (in the vernacular names extension), the presence in a specific region, the year of the first introduction (first collection) and/or last assessment/observation in that region, as well as extra information (in the distribution extension), and the habitat, native range, and ecofunctional group (in the description extension). The DAISIE dataset is no longer maintained, but can be used as a historical archive for researching and managing alien plants or compiling regional and national registries of alien species. Issues with the dataset can be reported at https://github.com/trias-project/daisie-checklist. We have released this dataset under a Creative Commons Attribution license (CC-BY 4.0). We would appreciate it if you follow the GBIF citation guidelines (https://www.gbif.org/citation-guidelines) when using the data. If you have any questions regarding this dataset, don’t hesitate to contact us via the contact information provided in the metadata or via https://twitter.com/trias_project. The publication of the checklist to GBIF was supported by the European Cooperation in Science and Technology (COST) action Alien CSI “CA17122 - Increasing understanding of alien species through citizen science” as a Short Term Scientific Mission “Publishing alien species checklist data for Europe through repeatable, open workflows”, with technical support provided by the Research Institute for Nature and Forest (INBO).

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• Type de publi. : Article dans une revue
• Date de publi. : 09/06/2020
• Auteurs : Marie DecalonneSandra dos SantosRémi GimenesFlorent GoubeGéraldine AbadieEmilie BenabidSaid AberraneVanina AmbrogiRaoul BaronPatrick BarthelemyIsabelle BauvinOlivier BelmonteRafik Ben AmmarSalma Ben Hadj YahiaYasmina BerrouanePhilippe BerthelotAlain BeuchéeEmmanuelle BillePascal BolotStéphanie Bordes-CouecouAntoine BouissouSandra BourdonNadège Bourgeois-NicolaosSophie BoyerChristian CattoenVincent CattoirChantal ChaplainCéline ChateletAurore ClaudinonNathalie ChautempsHélène CormierCéline Coroller-BecBenjamin CottéCarole de ChillazOlivier DauwalderAude DavyMartine DelormeMaryvonne DemasureLuc DesfrereMichel DrancourtClarisse DupinVéronique Faraut-DerouinArnaud FlorentinVirginie ForgetNicolas FortineauTania FoucanPierre FrangeKarine GambarottoGéraldine GascoinLaure GibertJacques GilquinAudrey GlanardJacqueline GrandoAlain GravetJérôme GuinardGeneviève Héry-ArnaudClaire HuartNadia IdriJean-Marc JellimannO. Join-LambertSylvie JoronPhilippe JouvencelMarie KempfSophie Ketterer-MartinonMouna KhecharemSerge KlosowskiFranck LabbeAdeline LacazetteFabrice LapeyreJérôme LarchePeggy LarroudeAnne Le PourhiennecNolwenn Le SachéSylvie LedruAnnick LefebvreClément LegeayFlorence LemannClaire LestevenMarion Levast-RaffinDavid LeysseneIsabelle LigiAlain LozniewskiPierre LureauFranck-Olivier MallavalEdith MalpoteStéphane MarretPascale MartresGuillaume MenardLaura MenvielleLaurent MereghettiVeronique MerlePascale MineryVirginie MorangeJulien MourdieAnaëlle MuggeoJean NakhlehMarie-Noëlle NoulardClaude OliveHugues PaturalPascale PennManuel PetitfrereBruno PozettoBrigitte RiviereAudrey RobineChristine Roques CeschinRaymond RuimyAmine SialiStéphanie SoiveSouad SlimaniAnne-Sophie TrentesauxDominique TrivierChristian VandenbusscheLaurent VilleneuveEvelyne WernerStéphane Le VuNathalie L. van Der Mee-Marquet
• Organismes : Centre Hospitalier Régional Universitaire de Tours CHU Trousseau [Tours] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion] Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier Intercommunal de Créteil Centre Hospitalier Régional Universitaire de Brest Hôpital de la Conception [CHU - APHM] Centre hospitalier de Pau Centre Hospitalier Universitaire de La Réunion AP-HP - Hôpital Antoine Béclère [Clamart] Centre Hospitalier de Calais Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut Necker Enfants-Malades Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier de la Côte Basque CHU Trousseau [Tours] Groupe Hospitalier du Havre AP-HP - Hôpital Antoine Béclère [Clamart] Hôpital Charles Nicolle [Rouen] Centre hospitalier [Valenciennes, Nord] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire de La Réunion GHT de l'Artois Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre Hospitalier Métropole Savoie [Chambéry] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Le Mans (CH Le Mans) Clinique du Val d'Ouest Hôpital Necker - Enfants Malades [AP-HP] Hospices Civils de Lyon Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] Centre Hospitalier Georges Renon [Niort] Centre Hospitalier Regional d'Orléans Hôpital Louis Mourier - AP-HP [Colombes] Microbes Evolution Phylogénie et Infections Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] AP-HP - Hôpital Antoine Béclère [Clamart] Interactions Gènes-Risques environnementaux et Effets sur la Santé Unité de Recherche Environnement Physique de la plante Horticole Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] CHU Pointe-à-Pitre / Abymes [Guadeloupe] Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire de La Réunion Centre Hospitalier Universitaire d'Angers Groupe de Recherche sur l'Adaptation Microbienne Hôpital Hôtel-Dieu [Paris] Hôpital Delafontaine Hospices Civils de Lyon Centre Hospitalier de Mulhouse, site du Hasenrain (Mulhouse) Centre Hospitalier Universitaire d'Angers Laboratoire Universitaire de Biodiversité et Ecologie Microbienne Centre hospitalier [Valenciennes, Nord] Hôpital Louis Mourier - AP-HP [Colombes] Service de réanimation néonatale [CHRU Nancy] Pathogénie des infections systémiques Centre Régional de PharmacoVigilance Nord-Pas-de-Calais [CHU Lille] Centre Hospitalier de la Côte Basque Centre de Recherche en Cancérologie Nantes-Angers Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] GHT de l'Artois Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) CHU Pointe-à-Pitre / Abymes [Guadeloupe] Centre hospitalier [Valenciennes, Nord] Polyclinique Médipôle Saint-Roch [Cabestany] Centre hospitalier de Pau Centre Régional de PharmacoVigilance Nord-Pas-de-Calais [CHU Lille] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] GHT de l'Artois Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire d'Angers Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Métropole Savoie [Chambéry] Université d'Auvergne - Clermont-Ferrand I Aix-Marseille Université - École de médecine Service de microbiologie [CHU Nancy] Centre Hospitalier Georges Renon [Niort] Centre Hospitalier Métropole Savoie [Chambéry] CHU Pointe-à-Pitre / Abymes [Guadeloupe] Normandie Université Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Service psychiatrique de l'enfant et de l'adolescent [CHU Hôpital Robert Debré] Service de Bactériologie-Virologie-Hygiène [Tours] Infectiologie et Santé Publique Registre EPIMAD Centre Hospitalier de Mulhouse, site du Hasenrain (Mulhouse) Centre Hospitalier Régional Universitaire de Tours Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Centre Hospitalier de Mulhouse, site du Hasenrain (Mulhouse) Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé Centre Hospitalier Le Mans (CH Le Mans) ELSAN Polyclinique Majorelle Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Intercommunal Castres-Mazamet Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Nice Centre Hospitalier Intercommunal de Créteil Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier de Lens Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras Centre hospitalier de Pau Centre Hospitalier Regional d'Orléans Institut de Veille Sanitaire Hôpital Bretonneau Hôpital Trousseau Infectiologie et Santé Publique
• Publié dans European Journal of Clinical Microbiology and Infectious Diseases le 22/10/2020

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Résumé : To increase the knowledge about S. capitis in the neonatal setting, we conducted a nationwide 3-month survey in 38 neonatal intensive care units (NICUs) covering 56.6% of French NICU beds. We demonstrated 14.2% of S. capitis BSI (S.capBSI) among nosocomial BSIs. S.capBSI incidence rate was 0.59 per 1000 patient-days. A total of 55.0% of the S.capBSIs were late onset catheter-related BSIs. The S. capitis strains infected preterm babies (median gestational age 26 weeks, median birth weight 855 g). They were resistant to methicillin and aminoglycosides and belonged to the NRCS-A clone. Evolution was favorable in all but one case, following vancomycin treatment.

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Fichiers liés : Decalonne2020_Article_StaphylococcusCapitisIsolatedF.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/06/2020
• Auteurs : Rémy A BonninDelphine GirlichAgnès B JoussetLauraine GauthierGaelle CuzonPierre BogaertsMarisa HaenniJean-Yves MadecElodie Couvé-DeaconOlivier BarraudNicolas FortineauPhilippe GlaserYouri GlupczynskiLaurent DortetThierry Naas
• Organismes : Team Resist [Le Kremlin-Bicêtre] French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Team Resist [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Team Resist [Le Kremlin-Bicêtre] French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Bacteriology-Hygiene unit [Le Kremlin-Bicêtre] Team Resist [Le Kremlin-Bicêtre] French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Bacteriology-Hygiene unit [Le Kremlin-Bicêtre] Team Resist [Le Kremlin-Bicêtre] French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Bacteriology-Hygiene unit [Le Kremlin-Bicêtre] CHU UCL Namur Unité Antibiorésistance et Virulence Bactériennes Unité Antibiorésistance et Virulence Bactériennes Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Team Resist [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Bacteriology-Hygiene unit [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance CHU UCL Namur Team Resist [Le Kremlin-Bicêtre] French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Bacteriology-Hygiene unit [Le Kremlin-Bicêtre] Team Resist [Le Kremlin-Bicêtre] French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae [Le Kremlin-Bicêtre] Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance Bacteriology-Hygiene unit [Le Kremlin-Bicêtre]
• Publié dans Scientific Reports le 26/10/2020

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Résumé : In Enterobacterales, the most common carbapenemases are Ambler's class A (KPC-like), class B (NDM-, VIM- or IMP-like) or class D (OXA-48-like) enzymes. This study describes the characterization of twenty-four OXA-23 or OXA-58 producing-Proteus mirabilis isolates recovered from human and veterinary samples from France and Belgium. Twenty-two P. mirabilis isolates producing either OXA-23 (n = 21) or OXA-58 (n = 1), collected between 2013 and 2018, as well as 2 reference strains isolated in 1996 and 2015 were fully sequenced. Phylogenetic analysis revealed that 22 of the 24 isolates, including the isolate from 1996, belonged to a single lineage that has disseminated in humans and animals over a long period of time. The blaOXA-23 gene was located on the chromosome and was part of a composite transposon, Tn6703, bracketed by two copies of IS15∆II. Sequencing using Pacbio long read technology of OXA-23-producing P. mirabilis VAC allowed the assembly of a 55.5-kb structure encompassing the blaOXA-23 gene in that isolate. By contrast to the blaOXA-23 genes, the blaOXA-58 gene of P. mirabilis CNR20130297 was identified on a 6-kb plasmid. The acquisition of the blaOXA-58 gene on this plasmid involved XerC-XerD recombinases. Our results suggest that a major clone of OXA-23-producing P. mirabilis is circulating in France and Belgium since 1996.

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Fichiers liés : s41598-020-66161-z.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 07/06/2020
• Auteurs : Tapé KouaméAboua Timothée OkpekonNicaise BonyAmon Diane N’tamonJean-François GallardSomia RharrabtiKarine LeblancElisabeth MourayPhilippe GrellierPierre ChampyMehdi A BeniddirPierre Le Pogam
• Organismes : Biomolécules : Conception, Isolement, Synthèse Laboratoire de Chimie Organique et de Substances Naturelles Université Félix Houphouët-Boigny [Abidjan, Côte d'Ivoire] Université Félix Houphouët-Boigny [Abidjan, Côte d'Ivoire] Université Félix Houphouët-Boigny [Abidjan, Côte d'Ivoire] Biomolécules : Conception, Isolement, Synthèse Université Félix Houphouët-Boigny [Abidjan, Côte d'Ivoire] Institut de Chimie des Substances Naturelles Biomolécules : Conception, Isolement, Synthèse Biomolécules : Conception, Isolement, Synthèse Molécules de Communication et Adaptation des Micro-organismes Molécules de Communication et Adaptation des Micro-organismes Biomolécules : Conception, Isolement, Synthèse Biomolécules : Conception, Isolement, Synthèse Biomolécules : Conception, Isolement, Synthèse
• Publié dans Molecules le 31/10/2020

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Résumé : Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.

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Fichiers liés : molecules-25-02654.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/06/2020
• Auteurs : Xavier AyrignacRadjiv GoulabchandEric JeziorskiPatricia RullierClarissa Carra-DallièreClaire LozanoPierre PortalesThierry VincentJean François ViallardNicolas Menjot de ChampfleurFrédéric Rieux-LaucatCaroline BesnardKoenig M.Claire GuissartPierre M LabaugePhilippe Guilpain
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Département de neurologie [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Département de neurologie [Montpellier] Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Régional Universitaire [Montpellier] Département de neurologie [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Service de médecine interne et maladies infectieuses [Bordeaux] Département de Neuroradiologie[Montpellier] Immunogenetics of pediatric autoimmune diseases Immunogenetics of pediatric autoimmune diseases Institut de Génétique Moléculaire de Montpellier Institut de Génétique Moléculaire de Montpellier Département de neurologie [Montpellier] Département de neurologie [Montpellier]
• Publié dans Neurology Neuroimmunology & Neuroinflammation le 28/10/2020

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Résumé : Objective To describe the clinical and radiologic neurologic characteristics of patients with cytotoxic T-lymphocyte antigen-4 ( CTLA4 ) haploinsufficiency. Methods Three patients from 2 families had neurologic manifestations in the context of CTLA4 haploinsufficiency. Their clinical and MRI findings are presented. Results A 16-year-old boy with a previous diagnosis of combined immunodeficiency presented with severe recurrent episodes of headaches, motor deficit, and seizures associated with waxing and waning gadolinium-enhancing FLAIR cortical/juxtacortical hyperintensities. His sister, who also had combined immunodeficiency, had a brain MRI when she was aged 13 years due to recent headaches and transient right hemianopsia. It revealed a gadolinium-enhancing left occipital white matter hyperintensity. Another 49-year-old woman had progressive visual loss and cerebellar ataxia in the context of recurrent pulmonary infections. All 3 patients were found to have inherited CTLA4 haploinsufficiency. Patient 1's general condition and neurologic manifestations were completely controlled with abatacept (CTLA4-Ig). Conclusions These cases suggest that in addition to the variable clinical penetrance and wide spectrum of CTLA4 haploinsufficiency, its neurologic spectrum is broad, ranging from recurrent tumefactive lesions to progressive deficits including cerebellar ataxia and optic atrophy with leukoencephalopathy. These phenotypes must be recognized, and should lead to a complete immunologic workup, because potentially effective targeted immunotherapy exists.

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Fichiers liés : e751.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/06/2020
• Auteurs : Emilie D’aldebertMuriel QuarantaMorgane SébertDelphine BonnetSylvain KirzinGuillaume PortierJean-Pierre DuffasSophie ChabotPhilippe LluelSophie AllartAudrey FerrandLaurent AlricClaire Racaud-SultanEmmanuel MasCéline DeraisonNathalie Vergnolle
• Organismes : Institut de Recherche en Santé Digestive Institut de Recherche en Santé Digestive Institut de Recherche en Santé Digestive Chirurgie Générale et Digestive [Purpan] Chirurgie Générale et Digestive [Purpan] Institut de Recherche en Santé Digestive Chirurgie Générale et Digestive [Purpan] Chirurgie Générale et Digestive [Rangueil] Urosphère SAS Urosphère SAS Centre de Physiopathologie Toulouse Purpan Institut de Recherche en Santé Digestive Chirurgie Générale et Digestive [Purpan] Institut de Recherche en Santé Digestive Institut de Recherche en Santé Digestive Service de Gastroentérologie et pancréatologie [CHU Toulouse] Institut de Recherche en Santé Digestive Institut de Recherche en Santé Digestive University of Calgary
• Publié dans Frontiers in Cell and Developmental Biology le 22/10/2020

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Résumé : Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders, where epithelial defects drive, at least in part, some of the pathology. We reconstituted human intestinal epithelial organ, by using three-dimension culture of human colon organoids. Our aim was to characterize morphological and functional phenotypes of control (non-IBD) organoids, compared to inflamed organoids from IBD patients. The results generated describe the epithelial defects associated with IBD in primary organoid cultures, and evaluate the use of this model for pharmacological testing of anti-inflammatory approaches. Human colonic tissues were obtained from either surgical resections or biopsies, all harvested in non-inflammatory zones. Crypts were isolated from controls (non-IBD) and IBD patients and were cultured up to 12-days. Morphological (size, budding formation, polarization, luminal content), cell composition (proliferation, differentiation, immaturity markers expression), and functional (chemokine and tight junction protein expression) parameters were measured by immunohistochemistry, RT-qPCR or western-blot. The effects of inflammatory cocktail or anti-inflammatory treatments were studied in controls and IBD organoid cultures respectively. Organoid cultures from controls or IBD patients had the same cell composition after 10 to 12-days of culture, but IBD organoid cultures showed an inflammatory phenotype with decreased size and budding capacity, increased cell death, luminal debris, and inverted polarization. Tight junction proteins were also significantly decreased in IBD organoid cultures. Inflammatory cytokine cocktail reproduced this inflammatory phenotype in non-IBD organoids. Clinically used treatments (5-ASA, glucocorticoids, anti-TNF) reduced some, but not all parameters. Inflammatory phenotype is associated with IBD epithelium, and can be studied in organoid cultures. This model constitutes a reliable human pre-clinical model to investigate new strategies targeting epithelial repair.

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Fichiers liés : Aldeberg-CDB-2020.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/06/2020
• Auteurs : Blandine TruffaultDavid BourhisAnne ChaputJeremie CalaisPhilippe RobinRomain Le PennecFrançois LuciaJean-Christophe LeclèreDorothy GujralPierre VeraPierre-Yves SalaunUlrike SchickRonan Abgral
• Organismes : CHRU Brest - Service de médecine nucléaire CHRU Brest - Service de médecine nucléaire Université européenne de Bretagne - European University of Brittany CHRU Brest - Service de médecine nucléaire Equipe Quantification en Imagerie Fonctionnelle CHRU Brest - Service de médecine nucléaire Université européenne de Bretagne - European University of Brittany CHRU Brest - Service de médecine nucléaire CHRU Brest - Service de radiothérapie Centre Hospitalier Régional Universitaire de Brest Service de médecine nucléaire [Rouen] Equipe Quantification en Imagerie Fonctionnelle CHRU Brest - Service de médecine nucléaire Université européenne de Bretagne - European University of Brittany CHRU Brest - Service de radiothérapie CHRU Brest - Service de médecine nucléaire Université européenne de Bretagne - European University of Brittany
• Publié dans Frontiers in Medicine le 01/11/2020

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Résumé : Aim: Several series have already demonstrated that intratumoral subvolumes with high tracer avidity (hotspots) in 18F-flurodesoxyglucose positron-emission tomography (FDG-PET/CT) are preferential sites of local recurrence (LR) in various solid cancers after radiotherapy (RT), becoming potential targets for dose escalation. However, studies conducted on head and neck squamous cell carcinoma (HNSCC) found only a moderate overlap between pre- and post-treatment subvolumes. A limitation of these studies was that scans were not performed in RT treatment position (TP) and were coregistred using a rigid registration (RR) method. We sought to study (i) the influence of FDG-PET/CT acquisition in TP and (ii) the impact of using an elastic registration (ER) method to improve the localization of hotpots in HNSCC. Methods: Consecutive patients with HNSCC treated by RT between March 2015 and September 2017 who underwent FDG-PET/CT in TP at initial staging (PETA) and during follow-up (PETR) were prospectively included. We utilized a control group scanned in non treatment position (NTP) from our previous retrospective study. Scans were registered with both RR and ER methods. Various sub-volumes (AX; x = 30, 40, 50, 60, 70, 80, and 90%SUVmax) within the initial tumor and in the subsequent LR (RX; x = 40 and 70%SUVmax) were overlaid on the initial PET/CT for comparison [Dice, Jaccard, overlap fraction = OF, common volume/baseline volume = AXnRX/AX, common volume/recurrent volume = AXnRX/RX]. Results: Of 199 patients included, 43 (21.6%) had LR (TP = 15; NTP = 28). The overlap between A30, A40, and A50 sub-volumes on PETA and the whole metabolic volume of recurrence R40 and R70 on PETR showed moderate to good agreements (0.41-0.64) with OF and AXnRX/RX index, regardless of registration method or patient position. Comparison of registration method demonstrated OF and AXnRX/RX indices (x = 30% to 50%SUVmax) were significantly higher with ER vs. RR in NTP (p < 0.03), but not in TP. For patient position, the OF and AXnRX/RX indices were higher in TP than in NTP when RR was used with a trend toward significance, particularly for x=40%SUVmax (0.50±0.22 vs. 0.31 ± 0.13, p = 0.094). Conclusion: Our study suggested that PET/CT acquired in TP improves results in the localization of FDG hotspots in HNSCC. If TP is not possible, using an ER method is significantly more accurate than RR for overlap estimation.

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Fichiers liés : fmed-07-00218.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/06/2020
• Auteurs : Alexandre LautretteAlexandre BoyerDidier GrusonLaurent ArgaudCarole SchwebelBernard TardyPhilippe VignonBruno MégarbanePierre SchoefflerPascal ChabrotJeannot SchmidtYves BoirieClaude GuérinMichaël DarmonKada KloucheBertrand SouweineJean DellamonicaJean-Christophe RichardBruno Pereira
• Organismes : Unité de soins intensifs [Clermont Ferrand] Laboratoire Microorganismes : Génome et Environnement Hôpital Pellegrin Hôpital Pellegrin Cardiovasculaire, métabolisme, diabétologie et nutrition Service de Réanimation Médicale [Grenoble] Groupe de recherche sur la thrombose, pharmacologie des antithrombotiques et situations à risque Service d'Accompagnement et Soins Palliatifs [CHU Limoges] Optimisation thérapeutique en Neuropsychopharmacologie Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière] CHU Gabriel Montpied [Clermont-Ferrand] CHU Gabriel Montpied [Clermont-Ferrand] Unité de soins intensifs [Clermont Ferrand] Unité de Nutrition Humaine Hôpital de la Croix-Rousse [CHU - HCL] Service de Réanimation Médicale [Grenoble] Centre Hospitalier Régional Universitaire [Montpellier] Unité de soins intensifs [Clermont Ferrand] Hôpital l'Archet Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis CHU Clermont-Ferrand
• Publié dans BMC Medical Education le 01/11/2020

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Résumé : Background: Lectures with slide presentations are widely used to teach evidence-based medicine to large groups. Take-home messages (THMs) are poorly identified and recollected by students. We investigated whether an instruction to list THMs in written form on slides would improve the retention thereof by residents, and the residents’ level of knowledge, 1 month after lectures. Methods: Prospective blinded randomized controlled study was conducted. Twelve lectures (6 control and 6 intervention lectures) were delivered to 73 residents. For the intervention lectures, the lecturers were instructed to incorporate clear written THMs into their slide presentations. The outcomes were ability of resident to recollect THMs delivered during a lecture (as assessed by accordance rate between the lecturers’ and residents’ THMs) and knowledge (as assessed by multiple choice questions (MCQs)). Results: Data for 3738 residents’ THMs and 3410 MCQs were analyzed. The intervention did not significantly increase the number of THMs written on slides (77% (n = 20/26), 95% CI 56–91 vs 64% (n = 18/28), 95% CI 44–81, p = 0.31) nor THMs retention (13% (n = 238/1791), 95% CI 12–15 vs 17% (n = 326/1947), 95% 15–18, p = 0.40) nor knowledge (63.8 ± 26.2 vs 61.1 ± 31.4 /100 points, p = 0.75). In multivariable analyses performed with all THMs written on slides from the two groups, a superior knowledge was associated with notetaking during lectures (OR 1.88, 95% CI 1.41–2.51) and THMs retention (OR 2.17, 95% CI 1.54–3.04); and THMs retention was associated with written THMs (OR 2.94, 95% CI 2.20–3.93). Conclusions: In lectures delivered to residents, a third of the THMs were not in written form. An intervention based on an explicit instruction to lecturers to provide THMs in written form in their slide presentations did not result in increased use of written THMs into the slide presentation or improvement of the THMs retention or level of knowledge. However, we showed that there was a strong positive association between writing THMs on a slide, retention of THMs and residents’ knowledge. Further researches are needed to assess interventions to increase written THMs in lectures by faculty.

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Fichiers liés : 2020 Lautrette et al., Impact of Takehome.pdf

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