Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Ghazaleh MehdipoorDavid JiménezLaurent BertolettiÁngeles FidalgoJuan Francisco Sanchez Muñoz-TorreroJosé Pedro Gonzalez-MartinezÁngeles Blanco-MolinaMiguel Ángel AibarPierre-Benoît BonnefoyRamin KhorasaniMartin PrinceBehnood BikdeliManuel MonrealMaría Dolores AdarragaMaría AgudPedro Azcarate-AgüeroJesús AibarJoaquín AlfonsoCristina AmadoJuan Ignacio ArcelusAitor BallazRaquel BarbaCristina Barbagelata, Manuel BarrónBelén Barrón-AndrésAna María CamonInmaculada CañasJuan CriadoCristina De AncosJavier De MiguelJorge del ToroPablo Demelo-RodríguezCarmen Díaz-PedrocheJosé Antonio Díaz-PeromingoRaquel Díaz-SimónJavier Díez-SierraIrene Milagros DomínguezJosé Carlos EscribanoAna Isabel FarfánCarmen Fernández-CapitánJosé Luis Fernández-ReyesKatia FloresCarme FontLlorenç FontIria FranciscoCristina GabaraFrancisco Galeano-ValleMaría Ángeles GarcíaFerran García-BragadoMaría García-GarcíaAránzazu García-RasoOlga Gavín-BlancoOlga Gavín-SebastiánMaría Carmen GayolAída Gil-DíazCovadonga Gómez-CuervoEnric GrauJavier Gutiérrez-GuisadoLuis Hernández-BlascoMarina IglesiasLuis Jara-PalomaresMaría Jesús JarasMaría Dolores JoyaInés JouBeatriz LacruzAntonio LaluezaRamón LecumberriJorge LimaPilar LlamasJosé Luis LoboLuciano López-JiménezPatricia López-MiguelJuan José López-NúñezRaquel López-ReyesJuan Bosco López-SáezManuel Alejandro LorenteAlicia LorenzoMónica LoringMarina LumbierresOlga MadridanoAna MaestrePablo Javier MarchenaMiguel Martín-FernándezJavier Miguel Martín-GuerraFrancisco Martín-MartosMeritxel MelladoMaría Isabel MercadoJorge MoisésMaría del Valle MoralesArturo Muñoz-BlancoDiego Muñoz-GuglielmettiJosé Antonio NietoManuel Jesús NúñezMaría Carmen Olivares, Clara Ortega-MichelMaría Dolores Ortega-RecioJeisson OsorioRemedios OteroDiana ParedesPedro ParraVirginia ParraJosé María PedrajasGaladriel PellejeroCristina Pérez-DuctorMaría Asunción Pérez-JacoísteDavid PesántezJosé Antonio PorrasJosé PortilloLluis ReigAntoni Riera-MestreAgustina RivasAna Rodríguez-CoboIrene Rodríguez-GalánConsolación Rodríguez-MatuteVladimir RosaCarmen María RubioPedro Ruiz-ArtachoNuria Ruiz-GiménezJusto Ruiz-RuizPablo Ruiz-SadaPaloma Ruiz-TorregrosaJoan Carles SahuquilloGiorgina SalgueiroÁngel SampérizTeresa SanchoSilvia SolerSusana SuárezJosé María SuriñachGregorio TiberioMaría Isabel TorresCarlos TolosaJavier Trujillo-SantosFernando UresandiEsther UsandizagaReina ValleJeronimo Ramón VelaGemma VidalPaula VillaresCarles ZamoraPaula GutiérrezFernando Javier VázquezThomas VanasscheChristophe VandenbrielePeter VerhammeJana HirmerovaRadovan MalýEstuardo SalgadoIlham BenzidiaAlessandra Bura-RiviereBenjamin CrichiPhilippe DebourdeauDominique Farge-BancelHélène HelferIsabelle MahéFarès MoustafaGéraldine PoenouSebastian SchellongAndrei BraesterBenjamin BrennerInna TzoranMaría AmitranoFranca BiloraCristiano BortoluzziBarbara BrandolinEugenio BucheriniMaurizio CiammaichellaDonatella ColaizzoFrancesco DentaliPierpaolo Di MiccoEliana GiammarinoElvira GrandoneFabio MaggiSara MangiacapraDaniela MastroiacovoRosa MaidaFederica PaceRaffaele PesaventoFulvio PomeroPaolo PrandoniRoberto QuintavallaAnna RocciCarmine SiniscalchiEros TiraferriAntonella TufanoAdriana VisonàNgoc Vo HongBeniamino ZalunardoRoberts KalejsDana KigitovicaAndris SkrideMelanie FerreiraJose MeirelesAbilio ReisMarijan BosevskiGorjan KrstevskiMarija ZdraveskaHenri BounameauxLucia MazzolaiJoseph CapriniAlfonso TafurIdo WeinbergHannah WilkinsHanh My Bui
• Organismes : Cardiovascular Research Foundation [New York, NY, USA] Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne Service de Médecine vasculaire et thérapeutique [CHU de Saint-Etienne]
• Publié dans Circulation: Cardiovascular Imaging le 24/10/2020

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Résumé : Background: The choice of the imaging modality for diagnosis of pulmonary embolism (PE) could be influenced by provider, patient or hospital characteristics, or over time. However, little is known about the choice of the diagnostic modalities in practice. The aim of this study was to evaluate the variations in the use of imaging modalities for patients with acute PE. Methods: Using the data from Registro Informatizado Enfermedad TromboEmbolica (RIETE), a prospective international registry of patients with venous thromboembolism (March 2001–January 2019), we explored the imaging modalities used in patients with acute PE. The imaging modalities included computed tomography pulmonary angiography, ventilation/perfusion scanning, pulmonary angiography, a combination of these tests, or PE signs and symptoms plus imaging-confirmed proximal deep vein thrombosis but no chest imaging. Results: Among 38 025 patients with confirmed PE (53.1% female, age: 67.3±17 years), computed tomography pulmonary angiography was the dominant modality of diagnosis in all RIETE enrollees (78.2% [99% CI, 77.6–78.7]); including pregnant patients (58.9% [99% CI, 47.7%–69.4%]) and patients with severe renal insufficiency (62.5% [99% CI, 59.9–65.0]). A greater proportion of patients underwent ventilation/perfusion scanning in larger hospitals compared with smaller hospitals (13.1% versus 7.3%, P <0.001). The use of computed tomography pulmonary angiography varied between 13.3% and 98.3% across the countries, and its use increased over time (46.5% in 2002 to 91.7% in 2018, P <0.001). Conclusions: In a large multinational PE registry, variations were observed in the use of imaging modalities according to patient or institutional factors and over time. However, computed tomography pulmonary angiography was the dominant modality of diagnosis, even in pregnancy and severe renal insufficiency. The safety, costs, and downstream effects of these tests on PE-related and non-PE-related outcomes warrant further investigation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Jean BorgomanoCyprien LanteaumePhilippe LeonideFrançois FournierLucien MontaggioniJean-Pierre Masse
• Organismes : Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Observatoire des Sciences de l'Univers Paris-Saclay Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement
• Publié dans AAPG Bulletin le 22/10/2020

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Résumé : A method of quantitative sequence stratigraphy based on stratigraphic forward modeling is tested on carbonate sedimentary systems (CSSs), especially on shallow-water carbonate platforms. Unless clear three-dimensional (3-D) and two-dimensional stratigraphic geometries crop out or are imaged by seismic data, 3-D carbonate sequence stratigraphic architectures are reconstructed assuming that one single factor representing changes in the ratio of the accommodation rate and the sedimentation rate (A'/S') through time can describe complex 3-D carbonate stratigraphic architectures at the basin scale. In this work, it is demonstrated that despite using a unique accommodation curve and a time-constant carbonate production, the preservation of theoretical A'/S', regarded as the fundamental parameter of sequence stratigraphy, is incomplete and spatially variable throughout a simple carbonate platform stratigraphic architecture. The apparent A'/S' sequence stratigraphic parameters preserved in the stratigraphic records are distinguished from the actual A'/S' parameters that control the stratigraphic response of CSSs. During overall accommodation increase, prograding and retrograding geometries can be time equivalent whereas coeval shallowing-and deepening-upward sequences may form. Apparent A'/S' spatial trends in one dimension are not consistently correlated between proximal and distal locations and do not typify specific stratigraphic architectures. This is the direct consequence of the spatial and synchronous variations in carbonate production rates along the platform profile. These results indicate that the construction of carbonate sedimentary piles, including carbonate reservoirs, cannot be simply based on standard sequence stratigraphic correlations of sparse and distant locations along platform-to-slope sedimentary profiles. Limitations of sequence stratigraphic correlations and uncertainties of A'/S' rates are addressed from an actual CSS case study (Lower Cretaceous Urgonian platform, southern Provence, France). A quantitative carbonate sequence stratigraphic workflow based on stratigraphic forward modeling is proposed.

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• Type de publi. : Rapport
• Date de publi. : 01/05/2020
• Auteurs : Gaël PiquèsNasrine AnwarFabrice BigotJean‑philippe DegeaiEmilie DelboisChristophe JordaBenjamin LuleyVivien MathéPauline PeterElodie ParisPierre PovedaNuria Rovira BuendiaSéverine Sanz-LalibertéBigna L. SteinerMargaux TillierJulie TouzeauOphélie Vauxion
• Organismes : Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes Université Paul-Valéry - Montpellier 3 Archéologie des Sociétés Méditerranéennes Gettysburg College LIttoral ENvironnement et Sociétés Université de Nantes Archéologie des Sociétés Méditerranéennes Centre Camille Jullian - Histoire et archéologie de la Méditerranée et de l'Afrique du Nord de la protohistoire à la fin de l'Antiquité Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes Integrative Prähistorische und Naturwissenschaftliche Archäologie, Basel Archéologie des Sociétés Méditerranéennes Materia Viva Centre Jean Berard

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Fichiers liés : rapport Lattes 2019.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Victor BobéeFanny DrieuxVinciane MarchandVincent SaterLiana VeresezanJean-Michel PicquenotPierre-Julien ViaillyMarie-Delphine LanicMathieu ViennotElodie BohersLucie ObericChristiane Copie-BergmanThierry Jo MolinaPhilippe GaulardCorinne HaiounGilles SallesHervé TillyFabrice JardinPhilippe Ruminy
• Organismes : UNIROUEN - UFR Santé Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut Mondor de Recherche Biomédicale Service d'anatomie pathologique [CHU Necker] Institut Mondor de Recherche Biomédicale Université Paris-Est Créteil Val-de-Marne - Faculté de médecine Service d'hématologie [Hôpital Edouard Herriot - HCL] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
• Publié dans Blood Cancer Journal le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Aline CanoNoémie ResseguierAbdoulaye OuattaraPascale de LonlayJean-Baptiste ArnouxAnais BrassierManuel SchiffSamia PichardAlexandre FabreCelia HoebekeNathalie GuffonAlain FouilhouxPierre BrouéGuy TouatiDries DobbelaereKarine MentionFrancois LabartheMarine TardieuLoïc de ParscauFrançois FeilletChrystèle BonnemainsAlice KusterPhilippe LabruneMagalie BarthLena DamajDelphine LamireauJulie BerbisBrigitte ChabrolPascal Auquier
• Organismes : Centre d'études et de recherche sur les services de santé et la qualité de vie Physiopathologie des Adaptations Nutritionnelles
• Publié dans The Journal of Pediatrics le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Sodiomon B SirimaLaura RichertArnaud ChêneAmadou T KonateCécilia CampionSébastien DechavanneJean-Philippe SemblatNadine BenhamoudaMathilde BahuaudPierre LoulergueAlphonse OuédraogoIssa NébiéMoïse KaboreDésiré KargougouAïssata BarrySan Maurice OuattaraValérie BoiletFlorence AllaisGwenaelle RoguetNicolas HavelangeElvira Lopez-PerezAlexis KuppersEleine KonatéCaroline RoussillonMyriam KantéLinda BelarbiAmidou DiarraNoelie HenryIssiaka SoulamaAmidou OuédraogoHelene EsperouOdile LeroyFrederic BatteuxEric TartourNicola K ViebigRodolphe ThiébautOdile LaunayBenoît Gamain
• Organismes : Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Centre Hospitalier Universitaire de Bordeaux Biologie Intégrée du Globule Rouge Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Bordeaux population health Biologie Intégrée du Globule Rouge Biologie Intégrée du Globule Rouge Hôpital Européen Georges Pompidou [APHP] AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Groupe de recherche action en santé Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Bordeaux population health Bordeaux population health AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] European Vaccine Initiative [Heidelberg, Germany] Institut National de la Santé et de la Recherche Médicale Institut National de la Santé et de la Recherche Médicale Hôpital Cochin [AP-HP] Bordeaux population health Bordeaux population health Hôpital Cochin [AP-HP] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Centre National de Recherche et de Formation sur le Paludisme [Ouagadougou, Burkina Faso] Institut National de la Santé et de la Recherche Médicale European Vaccine Initiative [Heidelberg, Germany] Hôpital Cochin [AP-HP] Institut National de la Santé et de la Recherche Médicale European Vaccine Initiative [Heidelberg, Germany] Statistics In System biology and Translational Medicine Hôpital Cochin [AP-HP] Biologie Intégrée du Globule Rouge
• Publié dans The Lancet Infectious Diseases le 29/10/2020

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Résumé : PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy. We assessed the safety and immunogenicity of PRIMVAC adjuvanted with Alhydrogel or glucopyranosyl lipid adjuvant in stable emulsion (GLA-SE) in French and Burkinabe women who were not pregnant.

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Fichiers liés : THELANCETID-HAL version.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Aiping ChenFatima-Zohra MokraneLawrence SchwartzFranck MorschhauserApasia StamatoullasJean-Marc Schiano de ColellaLaetitia VercellinoOlivier CasasnovasAdrien ChauchetAlain DelmerEmmanuelle Nicolas-VirelizierHervé GhesquièresMarie-Pierre Moles-MoreauAnna SchmittRémy DuléryKrimo BouabdallahCécile BorelMohamed TouatiBenedicte Deau-FischerFrédéric PeyradeRomain-David SebanGuillaume MansonPhilippe ArmandRoch HouotLaurent Dercle
• Organismes : New York Presbyterian Hospital New York Presbyterian Hospital New York Presbyterian Hospital Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Institut Paoli-Calmettes Service d'Hématologie Clinique (CHU de Dijon) Hôpital universitaire Robert Debré [Reims] Centre Léon Bérard [Lyon] Immuno-Biologie des Lymphomes [CIRI] Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] Centre Hospitalier Universitaire d'Angers Institut Bergonié [Bordeaux] Institut Universitaire du Cancer de Toulouse - Oncopole Service d'Hématologie biologique [CHU Limoges] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Institut Curie [Paris] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Dana-Farber Cancer Institute [Boston] Microenvironment, Cell Differentiation, Immunology and Cancer New York Presbyterian Hospital
• Publié dans Journal of Nuclear Medicine le 26/10/2020

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Résumé : Monoclonal antibodies (mAbs) against programmed cell death 1 (PD-1), such as nivolumab and pembrolizumab, are associated with high response rates in patients with relapsed or refractory classic Hodgkin lymphoma (HL). To date, no prognostic factor for overall survival (OS) has been established with these agents in HL. We examined whether the first early response assessment evaluated using F-FDG PET/CT may be associated with OS in this setting. This retrospective study included 45 patients from 34 institutions. In a masked, centralized review, 3 independent radiologists classified PET/CT scans obtained at a median of 2.0 mo (interquartile range, 1.7-3.7 mo) after nivolumab initiation using existing criteria (i.e., 2014 Lugano classification and 2016 LYRIC). Patients were classified according to 4 possible response categories: complete metabolic response (CMR), partial metabolic response (PMR), no metabolic response (NMR), or progressive metabolic disease (PMD). Because the OS of patients with NMR and PMR was similar, they were grouped together. OS was estimated using the Kaplan-Meier method and compared between groups using log-rank testing. Eleven patients (24%) died after a median follow-up of 21.2 mo. The classification was identical between Lugano and LYRIC because all 16 progression events classified as indeterminate response per LYRIC were confirmed on subsequent evaluations. Both Lugano and LYRIC classified patients as CMR in 13 cases (29%), PMD in 16 (36%), NMR in 4 (9%), and PMR in 12 (27%). The 2-y OS probability was significantly different in patients with PMD (0.53; 95% confidence interval [95%CI], 0.32-0.87), NMR or PMR (0.80; 95%CI, 0.63-1.00), and CMR (1.00; 95%CI, 1.00-1.00) in the overall population ( = 0.02, 45 patients), as well as according to a landmark analysis at 3 mo ( = 0.05, 32 patients). In relapsed or refractory HL patients treated with anti-PD-1 mAbs, the first early PET/CT assessment using either Lugano or LYRIC predicted OS and allowed early risk stratification, suggesting that PET/CT might be used to develop risk-adapted strategies.

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Fichiers liés : Chen et al-2019-Early 18F-FDG PET-CT response predicts survival in Relapsed.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Philippe MauryJean Benoit ThamboAlice MaltretNicolas CombesSebastien HascoetNicolas DervalMagalie LadouceurPhilippe AcarPascal AmedroFrédéric AnselmeFanny BajolleAdeline BasquinEmre BelliPierre BordacharGuillaume DuthoitSylvie Di FilippoLaurent FauchierEstelle GandjbakhchDaniel GrasCeline GronierClement KarsentyDidier KlugLinda KoutbiJérôme LacotteGabriel LaurentDaniela LauxJacques MansouratiEloi MarijonCaroline OvaertFrederic SacherNicolas SadoulJérôme TaiebVictor WaldmannKarine Warin-FressePascal DefayeOlivier PiotSerge Boveda
• Organismes : Centre Hospitalier Universitaire de Toulouse CHU Pessac Service de cardiologie pédiatrique [CHU Necker] Université Paris Cité Clinique Pasteur [Toulouse] Congenital Heart Disease Service, Marie Lannelongue Hospital, 92350 Le Plessis-Robinson, France. IHU-LIRYC Paris-Centre de Recherche Cardiovasculaire Université Paris Cité Hôpital Européen Georges Pompidou [APHP] Centre Hospitalier Universitaire de Toulouse Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Service de Cardiologie [CHU Rouen] Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Pôle des Cardiopathies Congénitales, Marie Lannelongue Hospital, 92350 Le Plessis-Robinson, Centre Hospitalier Universitaire de Bordeaux Institut de cardiologie [CHU Pitié-Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université - Faculté de Médecine Hôpital Louis Pradel [CHU - HCL] Centre Hospitalier Régional Universitaire de Tours CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Cardiopathies et mort subite [ERL 3147] Cabinet de Cardiologie Foetale Pediatrique et Congenitale Adulte et Groupement d'Exploration Radiologique et Cardiovasculaire, Clinique de l'Orangerie, 67000 Strasbourg Centre Hospitalier Universitaire de Toulouse Service de Cardiologie A Département de Cardiologie [Hôpital de la Timone - APHM] Institut Cardiovasculaire Paris Sud Service de Cardiologie [CHU de Dijon] Centre Chirurgical Marie Lannelongue Optimisation des régulations physiologiques Service de cardiologie pédiatrique [CHU Necker] Marseille medical genetics - Centre de génétique médicale de Marseille Marseille medical genetics - Centre de génétique médicale de Marseille IHU-LIRYC Service de Cardiologie [CHRU Nancy] Centre Hospitalier du Pays d'Aix Department of Cardiology, Brest University Hospital, 29200 Brest ITX - unité de recherche de l'institut du thorax Cardiac Stimulation and Rhythmology Centre cardiologique du Nord Clinique Pasteur et Groupe Rythmologie Stimulation Cardiaque/SFC
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : The population of patients with congenital heart disease (CHD) is continuously increasing, and a significant proportion of these patients will experience arrhythmias because of the underlying congenital heart defect itself or as a consequence of interventional or surgical treatment. Arrhythmias are a leading cause of mortality, morbidity and impaired quality of life in adults with CHD. Arrhythmias may also occur in children with or without CHD. In light of the unique issues, challenges and considerations involved in managing arrhythmias in this growing, ageing and heterogeneous patient population and in children, it appears both timely and essential to critically appraise and synthesize optimal treatment strategies. The introduction of catheter ablation techniques has greatly improved the treatment of cardiac arrhythmias. However, catheter ablation in adults or children with CHD and in children without CHD is more technically demanding, potentially causing various complications, and thus requires a high level of expertise to maximize success rates and minimize complication rates. As French recommendations regarding required technical competence and equipment are lacking in this situation, the Working Group of Pacing and Electrophysiology of the French Society of Cardiology and the Affiliate Group of Paediatric and Adult Congenital Cardiology have decided to produce a common position paper compiled from expert opinions from cardiac electrophysiology and paediatric cardiology. The paper details the features of an interventional cardiac electrophysiology centre that are required for ablation procedures in adults with CHD and in children, the importance of being able to diagnose, monitor and manage complications associated with ablations in these patients and the supplemental hospital-based resources required, such as anaesthesia, surgical back-up, intensive care, haemodynamic assistance and imaging. Lastly, the need for quality evaluations and French registries of ablations in these populations is discussed. The purpose of this consensus statement is therefore to define optimal conditions for the delivery of invasive care regarding ablation of arrhythmias in adults with CHD and in children, and to provide expert and – when possible – evidence-based recommendations on best practice for catheter-based ablation procedures in these specific populations.

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Fichiers liés : 2020 Maury et al., Position paper.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Domonkos CsehRachel ClimieLucile OffredoCatherine GuiboutFrédérique ThomasLuca ZanoliNicolas DanchinJames SharmanStéphane LaurentXavier JouvenPierre BoutouyrieJean-Philippe Empana
• Organismes : Paris-Centre de Recherche Cardiovasculaire
• Publié dans Arteriosclerosis, Thrombosis, and Vascular Biology le 27/10/2020

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Résumé : Objective: Impaired baroreflex function is an early indicator of cardiovascular autonomic imbalance. Patients with type 2 diabetes mellitus (T2D) have decreased baroreflex sensitivity (BRS), however, whether the neural and/or mechanical component of the BRS (nBRS and mBRS, respectively) is altered in those with high metabolic risk (HMR, impaired fasting glucose and/or metabolic syndrome) or with overt T2D, is unknown. We examined this in a community-based observational study, the Paris Prospective Study III (PPS3). Approach and Results: In 7626 adults aged 50 to 75 years, resting nBRS (estimated by low-frequency gain, from carotid distension rate and RR intervals [time intervals between successive R waves]) and mBRS were measured by high-precision carotid echotracking. The associations between overt T2D or HMR as compared with subjects with normal glucose metabolism (NGM) and nBRS or mBRS were quantified using multivariable linear regression analysis. There were 319 subjects with T2D (61±6 years, 77% male), 1450 subjects with HMR (60±6 years, 72% male), and 5857 subjects with NGM (59±6 years, 57% male). Compared with NGM subjects, nBRS was significantly lower in HMR subjects (β=−0.07 [95% CI, −0.12 to −0.01]; P =0.029) and in subjects with T2D (β=−0.18 [95% CI, −0.29 to −0.07]; P =0.002) after adjustment for confounding and mediating factors. Subgroup analysis suggests significant and independent alteration in mBRS only among HMR patients who had both impaired fasting glucose and metabolic syndrome. Conclusions: In this community-based study of individuals aged 50 to 75, a graded decrease in nBRS was observed in HMR subjects and patients with overt T2D as compared with NGM subjects.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2020
• Auteurs : Aroldo DargélStevenn VolantElisa BrietzkeB EtainEmilie OliéJean‐michel AzorinSebastian GardFrank BellivierThierry BougerolJean‐pierre KahnPaul RouxValérie AubinPhilippe CourtetMarion LeboyerChantal Henry
• Organismes : Perception et Mémoire / Perception and Memory Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB Queen's University [Kingston, Canada] Fondation FondaMental [Créteil] Pôle Neurosciences Fondation FondaMental [Créteil] Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier Fondation FondaMental [Créteil] Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Fondation FondaMental [Créteil] Pôle Neurosciences Fondation FondaMental [Créteil] Groupe d'imagerie neurofonctionnelle Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire de Nancy Fondation FondaMental [Créteil] Université de Versailles Saint-Quentin-en-Yvelines Centre Hospitalier de Versailles André Mignot Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Centre Hospitalier Régional Universitaire [Montpellier] Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale Fondation FondaMental [Créteil] Université Paris-Est Fondation FondaMental [Créteil] Perception et Mémoire / Perception and Memory Université Paris-Est
• Publié dans Bipolar Disorders le 28/10/2020

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Résumé : Objectives Diagnosis and management of bipolar disorder (BD) are limited by the absence of available biomarkers. Allostatic load (AL) represents the strain that stress, including the effects of acute phases and inter‐episode chronic mood instability, exerts on interconnected biological systems. This study aimed to operationalize an AL index and explore whether it could be relevant to better characterize BD patients with and without emotional hyper‐reactivity particularly those at higher risk of immune‐cardiometabolic dysregulation and functional impairment. Methods Levels of biomarkers of chronic inflammation (hsCRP and albumin), cardiovascular (systolic/diastolic blood pressure) and metabolic functions (fasting glucose, glycosylated hemoglobin, total cholesterol, LDL, HDL, and triglycerides) were measured in 1072 adult BD outpatients. Patients were classified in two groups (with/without emotional hyper‐reactivity) assessed by the Multidimensional Assessment of Thymic States scale. An Allostatic Load Index for BD (BALLI), comprising six biomarkers, was constructed using data‐driven biomarker selection. Results BALLI showed 81.1% accuracy with good sensitivity (81%) and specificity (81.2%) for characterizing BD patients presenting emotional hyper‐reactivity, elevated risk of inflammation (increased hsCRP, hypoalbuminemia) and cardiometabolic disturbances (hypertension, hyperglycemia, and hypertriglyceridemia). Patients classified by the BALLI as presenting emotional hyper‐reactivity had significantly lower global and cognitive functioning than those without emotional hyper‐reactivity (P < .0001). Conclusions A multidimensional approach based on a simple AL score (eg, BALLI) and dimensions of behavior (eg, emotional hyper‐reactivity) alongside mood is clinically relevant. AL index could be a useful tool to detect multisystemic physiological dysregulations in BD patients with/without emotional hyper‐reactivity particularly those at higher risk of immune‐cardiometabolic disturbances and functional impairment.

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