Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 08/04/2020
• Auteurs : Philippe ColsonJean-Christophe LagierJean‐pierre BaudoinJacques Bou KhalilBernard La ScolaDidier Raoult
• Organismes : Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans European Journal of Clinical Microbiology and Infectious Diseases le 22/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 08/04/2020
• Auteurs : Mahiul M K MuqitJean Pierre HubschmanSerge PicaudDouglas B MccreeryJan C van MeursRalf HornigGuillaume BucMartin DeterreCéline Nouvel-JaillardElodie BouilletClaire-Maelle FovetPhilippe HantrayeJosé SahelJoseph N MartelYannick Le Mer
• Organismes : Moorfields Eye Hospital University College London [UCL] University of California [Los Angeles] Institut de la Vision Huntington Medical Research Institutes [Pasadena, CA, États-Unis] Rotterdam Eye Hospital [Rotterdam, Pays-Bas] Erasmus University Medical Center [Rotterdam] Pixium Vision [Paris] Pixium Vision [Paris] Pixium Vision [Paris] Institut de la Vision Pixium Vision [Paris] Molecular Imaging Research Center [Fontenay-aux-Roses] Molecular Imaging Research Center [Fontenay-aux-Roses] Institut de la Vision Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts University of Pittsburgh School of Medicine Fondation Ophtalmologique Adolphe de Rothschild [Paris] University of Pittsburgh School of Medicine Fondation Ophtalmologique Adolphe de Rothschild [Paris]
• Publié dans PLoS ONE le 25/10/2020

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Résumé : PURPOSE: To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovoltaic wireless microchip in two animal models, and refine these surgical procedures for human trials. METHODS: Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central retina. The 1.5mm PRIMA chip was initially studied in feline eyes. PRIMA implant (2mm,1.5mm sizes) arrays were studied in primates. Feasibility of subretinal chip implantation was evaluated with a newly-developed surgical technique, with surgical complications and adverse events recorded. RESULTS: The 1.5mm implant was placed in the central retina of 11 feline eyes, with implantation duration 43-106 days. The 1.5mm implant was correctly positioned into central macula of 11 primate eyes, with follow-up periods of minimum 6 weeks (n = 11), 2 years (n = 2), and one eye for 3 years. One primate eye underwent multi-chip 1.5mm implantation using two 1.5mm chips. The 2mm implant was delivered to 4 primate eyes. Optical coherence tomography confirmed correct surgical placement of photovoltaic arrays in the subretinal space in all 26 eyes. Intraoperative complications in primate eyes included retinal tear, macular hole, retinal detachment, and vitreous hemorrhage that resolved spontaneously. Postoperatively, there was no case of significant ocular inflammation in the 1.5mm implant group. CONCLUSIONS: We report subretinal implantation of 1.5mm and 2mm photovoltaic arrays in the central retina of feline and central macula of primate eyes with a low rate of device-related complications. The in vivo PRIMA implantation technique has been developed and refined for use for a 2mm PRIMA implant in ongoing human trials

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Fichiers liés : journal.pone.0230713.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 07/04/2020
• Auteurs : Philippe RicaudMassimo del GuastaEric BazileNiramson AzouzAngelo LupiPierre DurandJean-Luc AttiéDana VeronVincent GuidardPaolo Grigioni
• Organismes : Centre national de recherches météorologiques Istituto Nazionale di Ottica Centre national de recherches météorologiques Centre national de recherches météorologiques CNR Institute of Atmospheric Sciences and Climate Laboratoire d'aérologie Laboratoire d'aérologie University of Delaware [Newark] Centre national de recherches météorologiques Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development
• Publié dans Atmospheric Chemistry and Physics le 31/10/2020

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Résumé : A comprehensive analysis of the water budget over the Dome C (Concordia, Antarctica) station has been performed during the austral summer 2018–2019 as part of the Year of Polar Prediction (YOPP) international campaign. Thin ( ∼ 100 m deep) supercooled liquid water (SLW) clouds have been detected and analysed using remotely sensed observations at the station (tropospheric depolarization lidar, the H2O Antarctica Microwave Stratospheric and Tropospheric Radiometer (HAMSTRAD), net surface radiation from the Baseline Surface Radiation Network (BSRN)), radiosondes, and satellite observations (CALIOP, Cloud-Aerosol LIdar with Orthogonal Polarization/CALIPSO, Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observations) combined with a specific configuration of the numerical weather prediction model: ARPEGE-SH (Action de Recherche Petite Echelle Grande Echelle –Southern Hemisphere). The analysis shows that SLW clouds were present from November to March, with the greatest frequency occurring in December and January when ∼ 50 % of the days in summer time exhibited SLW clouds for at least 1 h. Two case studies are used to illustrate this phenomenon. On 24 December 2018, the atmospheric planetary boundary layer (PBL) evolved following a typical diurnal variation, which is to say with a warm and dry mixing layer at local noon thicker than the cold and dry stable layer at local midnight. Our study showed that the SLW clouds were observed at Dome C within the entrainment and the capping inversion zones at the top of the PBL. ARPEGE-SH was not able to correctly estimate the ratio between liquid and solid water inside the clouds with the liquid water path (LWP) strongly underestimated by a factor of 1000 compared to observations. The lack of simulated SLW in the model impacted the net surface radiation that was 20–30 W m−2 higher in the BSRN observations than in the ARPEGE-SH calcu- lations, mainly attributable to the BSRN longwave downward surface radiation being 50 W m−2 greater than that of ARPEGE-SH. The second case study took place on 20 December 2018, when a warm and wet episode impacted the PBL with no clear diurnal cycle of the PBL top. SLW cloud appearance within the entrainment and capping inversion zones coincided with the warm and wet event. The amount of liquid water measured by HAMSTRAD was ∼ 20 times greater in this perturbed PBL than in the typical PBL. Since ARPEGE-SH was not able to accurately reproduce these SLW clouds, the discrepancy between the observed and calculated net surface radiation was even greater than in the typical PBL case, reaching +50 W m−2, mainly attributable to the downwelling longwave surface radiation from BSRN being 100 W m−2 greater than that of ARPEGE-SH. The model was then run with a new partition function favouring liquid water for temperatures below −20 down to −40 ◦C. In this test mode, ARPEGE-SH has been able to generate SLW clouds with modelled LWP and net surface radiation consistent with observations during the typical case, whereas, during the perturbed case, the modelled LWP was 10 times less than the observations and the modelled net surface radiation remained lower than the observations by ∼ 50 W m−2. Accurately modelling the presence of SLW clouds appears crucial to correctly simulate the surface energy budget over the Antarctic Plateau.

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Fichiers liés : acp-20-4167-2020.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/04/2020
• Auteurs : Simon BoussionFabienne EscandeAnne‐sophie JourdainThomas SmolPerrine BrunelleCéline DuhamelYves AlembikTania Attie-BitachGeneviève BaujatAnne BazinMaryse BonnièrePhilippe CarassouDominique CarlesLouise DevismeCyril GoizetAlice GoldenbergSarah GrottoAgnès GuichetPierre‐simon JoukLaurence LoeuilletCharlotte MechlerCaroline MichotFanny PelluardAudrey PutouxSandra WhalenJamal GhoumidSylvie Manouvrier-HanuFlorence Petit
• Organismes : Biologie Computationnelle et Mathématique Hôpital Femme Mère Enfant [CHU - HCL] Genetics of Neurodevelopment
• Publié dans Human Mutation le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 02/04/2020
• Auteurs : Hanspeter NaegeliJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoFrancisco Javier MorenoEwen MullinsFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiFernando ÁlvarezMichele ArdizzoneGiacomo de SanctisYann DevosAntonio Fernandez‐dumontAndrea GennaroJose Ángel Gómez RuizAnna LanzoniFranco Maria NeriNikoletta PapadopoulouKonstantinos Paraskevopoulos
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Oilseed rape MS11 has been developed to confer male sterility and tolerance to glufosinate-ammoniumcontaining herbicides. Based on the information provided in the application and in line with the scope of application EFSA-GMO-BE-2016-138, the genetically modified organism (GMO) Panel concludes that the molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic characteristics tested between oilseed rape MS11 and its conventional counterpart needs further assessment. No conclusions can be drawn for the compositional analysis due to the lack of an appropriate compositional data set. No toxicological or allergenicity concerns are identified for the Barnase, Barstar and PAT/bar proteins expressed in oilseed rape MS11. Owing to the incompleteness of the compositional analysis, the toxicological, allergenicity and nutritional assessment of oilseed rape MS11 cannot be completed. In the case of accidental release of viable oilseed rape MS11 seeds into the environment, oilseed rape MS11 would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the scope of the application. Since oilseed rape MS11 is designed to be used only for the production of hybrid seed, it is not expected to be commercialised as a stand-alone product for food/feed uses. Thus, seeds harvested from oilseed rape MS11 are not expected to enter the food/feed chain, except accidentally. In this context, the GMO Panel notes that, oilseed rape MS11 would not pose risk to humans and animals, while the scale of environmental exposure will be substantially reduced compared to a stand-alone product.

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• Type de publi. : Article dans une revue
• Date de publi. : 02/04/2020
• Auteurs : Elie CousinEmmanuel OgerJean-Hugues DalleYves BertrandSophie PertuiselCécile PochonClaire GalambrunPauline SimonBenedicte BrunoCatherine PaillardPascale SchneiderPierre RohrlichRégis Peffault de La TourClaire FreyconJean-Francois EliaouGilbert SemanaPhilippe JonveauxSeverine DrunatPierre BordigoniVirginie Gandemer
• Organismes : Centre Hospitalier Régional Universitaire de Nancy
• Publié dans Pediatric Hematology-Oncology le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2020
• Auteurs : Benedicte GaboritJean-Baptiste JullaSamaher BesbesMatthieu ProustClara VincentelliBenjamin AlosPatricia AncelFawaz AlzaidRodrigue GarciaPhilippe MaillyFlorence SabatierMaud RighiniPierre GasconFrédéric MatontiMarie HoussaysLouisa GoumidiLucile VignaudXavier GuillonneauAli ErginayBénédicte DupasJennifer Marie-LouiseMarianne AutiéTiphaine Vidal-TrecanJean-Pierre RivelineNicolas VenteclefPascale MassinLaurent MullerAnne DutourJean-François GautierStéphane Germain
• Organismes : Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Hôpital Lariboisière Carcinose Angiogenèse et Recherche Translationnelle ; Angiogenese et recherche translationnelle Centre interdisciplinaire de recherche en biologie Centre interdisciplinaire de recherche en biologie Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre interdisciplinaire de recherche en biologie Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre de Recherche des Cordeliers Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre interdisciplinaire de recherche en biologie Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Assistance Publique - Hôpitaux de Marseille Assistance Publique - Hôpitaux de Marseille Assistance Publique - Hôpitaux de Marseille Assistance Publique - Hôpitaux de Marseille Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Polytech'Paris - Sorbonne Université Polytech'Paris - Sorbonne Université Service d'ophthalmologie [CHU Lariboisière] Service d'ophthalmologie [CHU Lariboisière] Service d'ophthalmologie [CHU Lariboisière] Service d'ophthalmologie [CHU Lariboisière] Hôpital Lariboisière-Fernand-Widal [APHP] Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Service d'ophthalmologie [CHU Lariboisière] Centre interdisciplinaire de recherche en biologie Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre de Recherche des Cordeliers Centre interdisciplinaire de recherche en biologie
• Publié dans Journal of Clinical Endocrinology and Metabolism le 01/11/2020

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Résumé : Aims: Recent trials provide conflicting results on the association between glucagon-like peptide 1 receptor agonists (GLP-1RA) and diabetic retinopathy (DR). The aim of the AngioSafe type 2 diabetes (T2D) study was to determine the role of GLP-1RA in angiogenesis using clinical and preclinical models.Methods: We performed two studies in humans. In study 1, we investigated the effect of GLP-1RA exposure from T2D diagnosis on the severity of DR, as diagnosed with retinal imaging (fundus photography). In study 2, a randomized 4-week trial, we assessed the effect of liraglutide on circulating hematopoietic progenitor cells (HPCs), and angio-miRNAs. We then studied the experimental effect of Exendin-4, on key steps of angiogenesis: in vitro on human endothelial cell proliferation, survival and three-dimensional vascular morphogenesis; and in vivo on ischemia-induced neovascularization of the retina in mice.Results: In the cohort of 3154 T2D patients, 10% displayed severe DR. In multivariate analysis, sex, disease duration, glycated hemoglobin (HbA1c), micro- and macroangiopathy, insulin therapy and hypertension remained strongly associated with severe DR, while no association was found with GLP-1RA exposure (o 1.139 [0.800-1.622], P = .47). We further showed no effect of liraglutide on HPCs, and angio-miRNAs. In vitro, we demonstrated that exendin-4 had no effect on proliferation and survival of human endothelial cells, no effect on total length and number of capillaries. Finally, in vivo, we showed that exendin-4 did not exert any negative effect on retinal neovascularization. Conclusions: The AngioSafe T2D studies provide experimental and clinical data confirming no effect of GLP-1RA on angiogenesis and no association between GLP-1 exposure and severe DR.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2020
• Auteurs : Jean-Philip BrugalAlain ArgantMyriam Boudadi-MaligneEvelyne Crégut-BonnoureRoman CroitorPhilippe FernandezJean-Baptiste FourvelPhilippe FosseJean-Luc GuadelliBruno LabePierre MagniezA. Uzunidis
• Organismes : Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Museum Requien Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique Laboratoire méditerranéen de préhistoire Europe-Afrique
• Publié dans Annales de Paléontologie le 01/11/2020

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Résumé : This contribution presents a general account and summary of the research carried out over the past decades on the Quaternary faunas of France. This country is located in the center of Western Europe, and presents distinct topographical features and very varied climatic influences. This paper is the result of collaborative work between French teams and different researchers specialized in the paleontology of large mammals. Over a hundred paleontological or archaeological sites are mentioned in this review, which covers a broad chronological period, ranging from the Early (including the end of Pliocene/Gelasien) and Middle Pleistocene to the Late Pleistocene. One of the aims of this work is to present studies of the main families or subfamilies of herbivores (Equidae, Rhinocerotidae, Bovidae [Bovines, Caprines, Antilopines, and Rupicaprines], Cervidae, Proboscid) and carnivores (Canidae, Ursidae, Mustelidae, Hyenidae, Felidae). It is not exhaustive at the generic and specific level, but details on the taxonomic status, evolutionary levels and biochronological importance of the most important taxa are given alongside an extensive and up-to-date bibliography of French works.

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Fichiers liés : Brugal et al _ANNPAL_102384.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2020
• Auteurs : Laurent OzielAlberto BaudenaMathieu ArdynaPhilippe MassicotteJean-Christophe ScilienJean-Baptiste SalléeRandi Brunvær IngvaldsenEmmanuel DevredMarcel Babin
• Organismes : Takuvik Joint International Laboratory ULAVAL-CNRS Processus et interactions de fine échelle océanique Laboratoire d'océanographie de Villefranche Takuvik Joint International Laboratory ULAVAL-CNRS Takuvik Joint International Laboratory ULAVAL-CNRS Processus et interactions de fine échelle océanique Institute of Marine Research [Bergen] Fisheries and Oceans Canada = Pêches et Océans Canada [Ottawa] Takuvik Joint International Laboratory ULAVAL-CNRS
• Publié dans Nature Communications le 23/10/2020

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Résumé : The Arctic marine biome, shrinking with increasing temperature and receding sea-ice cover, is tightly connected to lower latitudes through the North Atlantic. By flowing northward through the European Arctic Corridor (the main Arctic gateway where 80% of in-and outflow takes place), the North Atlantic Waters transport most of the ocean heat, but also nutrients and planktonic organisms toward the Arctic Ocean. Using satellite-derived altimetry observations, we reveal an increase, up to twofold , in North Atlantic current surface velocities over the last 24 years. More importantly, we show evidence that the North Atlantic current and its variability shape the spatial distribution of the coccolithophore Emiliania huxleyi (Ehux), a tracer for temperate ecosystems. We further demonstrate that bio-advection, rather than water temperature as previously assumed, is a major mechanism responsible for the recent poleward intrusions of southern species like Ehux. Our findings confirm the biological and physical "Atlantification" of the Arctic Ocean with potential alterations of the Arctic marine food web and biogeochemical cycles.

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Fichiers liés : s41467-020-15485-5.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2020
• Auteurs : Pauline CuisenierBénédicte TestudLorella MinottiSamuel El Bouzaïdi TialiLaurence MartineauAnne-Sophie JobAgnès TrébuchonPierre DemanManik BhattacharjeeDominique M. HoffmannJean-Philippe LachauxMonica BaciuPhilippe KahaneMarcela Perrone-Bertolotti
• Organismes : Université Grenoble Alpes - UFR Médecine Laboratoire de Psychologie et NeuroCognition Département de neurologie Laboratoire de Psychologie et NeuroCognition Groupe d'imagerie neurofonctionnelle Institut de Neurosciences des Systèmes ID17 - Bio-medical Beamline Groupe d'imagerie neurofonctionnelle Département de neurochirurgie Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Laboratoire de Psychologie et NeuroCognition Institut universitaire de France Département de neurologie Laboratoire de Psychologie et NeuroCognition Institut universitaire de France
• Publié dans Journal of Neurosurgery le 26/10/2020

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