Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer
- Type de publi. : Article dans une revue
- Date de publi. : 13/03/2020
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Auteurs :
Caroline RousseauDavid M GoldenbergMathilde ColombiéJean-Charles SébillePhilippe MeinganLudovic FerrerPierre BaumgartnerEvelyne M CeratoDamien MassonMario CamponeAurore RauscherVincent FleuryCatherine LabbéAlain Faivre-ChauvetJean-Sebastien FresnelClaire ToquetJacques BarbetRobert M SharkeyLoïc CampionFrançoise Kraeber-Bodéré
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Organismes :
Nuclear Oncology
IBC Pharmaceuticals Inc [Morris Plains, NJ, USA]
Immunomedics Inc. [Morris Plains, NJ, USA]
Institut de Cancérologie de l'Ouest [Angers/Nantes]
Service de Médecine Nucléaire [Nantes]
Institut de Cancérologie de l'Ouest [Angers/Nantes]
Service de Médecine Nucléaire [Nantes]
Institut de Cancérologie de l'Ouest [Angers/Nantes]
Service de Radiologie [Nantes]
Nuclear Oncology
Institut de Cancérologie de l'Ouest [Angers/Nantes]
Institut de Cancérologie de l'Ouest [Angers/Nantes]
PHU 11 Pharmacie [CHU Nantes]
Délégation à la Recherche Clinique et à l'Enovation [Nantes]
Département de Biologie des Cancers [ICO, Nantes]
Institut d'oncologie de l'Ouest [CHU Nantes]
Institut de Cancérologie de l'Ouest [Angers/Nantes]
Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
PHU 11 Pharmacie [CHU Nantes]
Service de Médecine Nucléaire [Nantes]
Service de Radiologie [Nantes]
Service de Médecine Nucléaire [Nantes]
Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Institut de Cancérologie de l'Ouest [Angers/Nantes]
Institut d'oncologie de l'Ouest [CHU Nantes]
Département de Pathologie [CHU Nantes]
GIP ARRONAX [Nantes]
Immunomedics Inc. [Morris Plains, NJ, USA]
Integrative Oncogenomics of Multiple Myeloma Pathogenesis and Progression
Plateforme de Biométrie [CHU Nantes]
Nuclear Oncology
Service de Médecine Nucléaire [Nantes]
- Publié dans Journal of Nuclear Medicine le 26/10/2020
Résumé : Purpose: This prospective study evaluated the imaging performance of a novel immunological pretargeting positron-emission tomorgraphy (immuno-PET) method in patients with HER2-negative, carcinoembryonic antigen (CEA)-positive, metastatic breast cancer (BC), compared to computed tomography (CT), bone magnetic resonance imaging (MRI), and 18Fluorodeoxyglucose PET (FDG-PET). Patients and Methods: Twenty-three patients underwent whole-body immuno-PET after injection of 150 MBq 68Ga-IMP288, a histamine-succinyl-glycine peptide given following initial targeting of a trivalent anti-CEA, bispecific, anti-peptide antibody. The gold standards were histology and imaging follow-up. Tumor standard uptake values (SUVmax and SUVmean) were measured, and tumor burden analyzed using Total Tumor Volume (TTV) and Total Lesion Activity (TLA). Results: Total lesion sensitivity of immuno-PET and FDG-PET was 94.7% (1116/1178) and 89.6% (1056/1178), respectively. Immuno-PET had a somewhat higher sensitivity than CT and FDG-PET in lymph nodes (92.4% vs 69.7% and 89.4%, respectively) and liver metastases (97.3% vs 92.1% and 94.8%, respectively), whereas sensitivity was lower for lung metastases (48.3% vs 100% and 75.9%, respectively). Immuno-PET showed higher sensitivity than MRI and FDG-PET for bone lesions (95.8% vs 90.7% and 89.3%, respectively). In contrast to FDG-PET, immuno-PET disclosed brain metastases. Despite equivalent tumor SUVmax, SUVmean, and TTV, TLA was significantly higher with immuno-PET compared to FDG PET (P = 0.009). Conclusion: Immuno-PET using anti-CEA/anti-IMP288 bispecific antibody, followed by 68Ga-IMP288, is a potentially sensitive theranostic imaging method for HER2-negative, CEA-positive, metastatic BC patients, and warrants further research.
Fichiers liés :
ArticleRousseau2020Eq13.pdf
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