Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 24/07/2025
• Auteurs : Delphine BonhommeHugo VayssetEirene Marie Q. EdnacotVasco RodriguesYazan SalloumJean CuryAnny WangAxel BenchetritPierre AffaticatiVeronica Hernandez-TrejoPaul VittotCharlie BoriesAlexis CornecJean-Pierre LevraudPedro P HernándezPhilippe BenarochBenjamin MorehouseAude BernheimEnzo Z Poirier
• Organismes : Immunité et cancer Diversité moléculaire des microbes / Molecular diversity of microbes AgroParisTech University of California [Irvine] Immunité et cancer Génétique et Biologie du Développement Diversité moléculaire des microbes / Molecular diversity of microbes University of California [Irvine] Transgénèse pour les Etudes Fonctionnelles sur les Organismes Modèles Transgénèse pour les Etudes Fonctionnelles sur les Organismes Modèles Immunité et cancer Immunité et cancer Immunité et cancer Immunité et cancer Transgénèse pour les Etudes Fonctionnelles sur les Organismes Modèles NeuroInfection et Immunité - NeuroInfection and Immunity Génétique et Biologie du Développement Immunité et cancer University of California [Irvine] Diversité moléculaire des microbes / Molecular diversity of microbes Immunité et cancer
• Publié dans Science le 22/10/2020

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Résumé : Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent information regulator 2 (SIR2) protein domain, present in antiphage systems, plays a role in eukaryotic innate immunity. We identified SIRal, a human protein with a SIRim domain (subtype of SIR2) that plays a pivotal role in the animal Toll-like receptor pathway of innate immunity and protects against bacterial and viral infections. Proteins containing a SIRim domain are found across 19% of eukaryotic genomes, including zebrafish, where SIRal plays a role in inflammation. This work opens up avenues of research on the immune role of eukaryotic SIRim proteins as well as on the involvement of SIRal in human pathology.

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Fichiers liés : adr8536_CombinedPDF_v3-2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/07/2025
• Auteurs : Jean-Charles PicaudOlivier ClarisMercedes Gil-CamposIgnacio Salamanca de la CuevaLuc CornettePhilippe AllietAndré LekeMireille CastanetHugues PiloquetVirginie de HalleuxDelphine MitanchezYvan VandenplasPierre MatonFrank JochumDirk OlbertzSergio Negre PolicarpoLuca LavalleCecilia FumeroPaula Rodriguez-GarciaJanne Marie MollIrma Silva-ZolezziBoutaina ZemraniNicholas HaysNorbert SprengerJavier Miranda-Mallea
• Organismes : Hôpital de la Croix-Rousse [CHU - HCL] Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Université Claude Bernard Lyon 1 Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Neuroendocrine, Endocrine and Germinal Differentiation Communication Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Physiopathologie des Adaptations Nutritionnelles Centre Hospitalier Régional Universitaire de Tours Vrije Universiteit Brussel [Bruxelles] Nestlé Institute of Health Sciences SA [Lausanne, Switzerland] Nestlé Research Center | Centre de recherche Nestlé [Lausanne]
• Publié dans Frontiers in Nutrition le 25/10/2020

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Résumé : Gut health and microbiome development are closely linked in early life, with human milk oligosaccharides (HMOs) playing a key role. This study reports results through 4 months of age from a trial evaluating an infant formula containing a synbiotic blend of HMOs and probiotics, focusing on growth, gastrointestinal (GI) tolerance, and gut health biomarkers from birth to 15 months. Materials and methods Healthy infants aged ≤14 days were randomized to receive either the experimental formula (SYN; control formula supplemented with six HMOs and two probiotics [ B. infantis , B. lactis ]) or the control formula (CTRL; partially hydrolyzed 100% whey-based formula). A non-randomized breastfed (BF) group served as a reference. The primary endpoint was weight gain velocity in SYN vs. CTRL through 4 months of age. Secondary endpoints included fecal outcomes (abundance of bifidobacteria, immune and gut health markers), GI tolerance, and adverse events (AEs). Results The full analysis set (FAS) included 313 infants (118 in SYN, 114 in CTRL, and 81 BF), while the per-protocol population (PP) included 227 infants (84 in SYN, 84 in CTRL, and 59 BF). Weight gain velocity through 4 months in the SYN group was non-inferior to that in the CTRL group in both FAS and PP analyses (both p < 0.0001). Parent-reported GI tolerance and stool patterns were similar between SYN and CTRL groups through 4 months. At 3 months, Bifidobacteria abundance was significantly higher in the SYN group compared to the CTRL group ( p = 0.004). Fecal pH was lower in the SYN group than in the CTRL group ( p = 0.018) and more closely resembled that of the BF group. Immune and gut health markers were similar between the SYN and BF groups. No significant differences in AEs were observed across groups. Conclusion The synbiotic-supplemented infant formula supported healthy, age-appropriate growth, good GI tolerance, and increased the abundance of beneficial bifidobacteria through4 months of age.

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Fichiers liés : 2025_Picaud_Front_Nutrition.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 23/07/2025
• Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczYiming AbulaitiBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatthew John AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhMelike AkbiyikTorsten AkessonAndrei AkimovDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertUna Helena AlbertiPietro AlbicoccoGuillaume AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeJonny AllenJulia Frances AllenPhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesThiziri AmezzaDante AmideiBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosKieran Robert AmosDimitra AmperiadouShiwen AnChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanMichaela ArampatziSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaKanae AsaiSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupArnav Sunil AvadGiuseppe AvolioKonstantinos AxiotisAmir AzzamDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerPaolo BagnaiaMarzieh BahmaniDaniel BahnerKehang BaiJohn BainesLuke BainesKeith BakerEvelin BakosDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzIsaac BamwidhiElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosSergey BarsovFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosMarta Baselga BacarditSaleh BashiriAhmed BassalatMatthew Joseph BassoSusan BatajuRussell BateRichard BatesSouad BatlamousMarco BattagliaDaariimaa BattulgaMatteo BauceMichael BauerPatrick BauerLukas BayerTomas BazzanoJames BeachamTristan BeauJean Yves BeaucampPierre-Hugues BeaucheminPhilip BechtleHans Peter BeckKathrin BeckerAndrew BeddallVadim BednyakovChris BeeLars BeemsterMarcia BegalliMichael BegelJanna Katharina BehrJoshua Falco BeirerFlorian BeisiegelMohamed BelfkirGideon BellaLorenzo BellagambaAlain BelleriveCasey Dominik BellgraphPanagiotis BellosKonstantin BeloborodovIlyas BenaoumeurDriss BenchekrounFatima BendebbaYan BenhammouKees BenkendorferLydia Audrey BeresfordMatteo Mario BerettaElin Bergeaas KuutmannNicolas BergerBenedikt Ludwig BergmannJuerg BeringerGregorio BernardiCatrin BerniusFlorian Urs BernlochnerAdrian Berrocal GuardiaTracey BerryPeter BertaAnne-Sophie BertholdAnnalisa BertiRaphael BertrandSiegfried BethkeAlessandra BettiAdrian BevanLucas BezioNaman Kumar BhallaShudhashil BharthuarSomadutta BhattaPrajita BhattaraiZubair BhattiKartik Deepak BhideVallary Shashikant BhopatkarRiccardo Maria BianchiGianluca BiancoOtmar BiebelMichela BigliettiSully BillingsleyYassine BimgdiMarcello BindiAnna BinghamAhmet BingulCesare BiniGareth Adam BirdMattias BirmanMarek BirosStanislav BiryukovTobias BisanzEmanuele BisceglieJyoti Prakash BiswalDiptaparna BiswasIngo BlochAndrew James BlueUlla BlumenscheinViktor BobrovnikovLucrezia BoccardoMichael BoehlerBurkhard BohmDanijela BogavacAlexander BogdanchikovLaura BoggiaVeronique BoisvertPetar BokanTomasz BoldMarco BombenMarcella BonaMaarten BoonekampAlbert Gyorgy BorbelyIurii BordulevGuennadi BorissovDaniela BortolettoDavide BoscheriniMartine Fernandez-BosmanKhalil BouaoudaNaseem BouchharLeo BoudetJoseph BoudreauEva Bouhova-ThackerDjamel Eddine BoumedieneRomain BouquetAntonio BoveiaJamie BoydDiallo BoyeIgor BoykoLeon BozianuJuraj BracinikNihal BrahimiGerhard Immanuel BrandtOleg BrandtBenjamin Paul BrauJim BrauRoy Schimmel BrenerLydia BrennerRichard BrennerShikma BresslerGreta BriantiDavid BrittonDaniel BritzgerIan BrockRaymond BrockGustaaf BrooijmansJammel BrooksEthan Michael BrooksLiza BrostLeesa BrownLaura Elaine BruceTim Lukas BrucklerPawel Bruckman de RenstromBen BruersAlessia BruniGraziano BruniDavid BrunnerMarco BruschiNello BruscinoTrygve BuanesQuentin BuatDaniel Alexander BuchinAndy BuckleyOleg BulekovBrendon BullardSergey BurdinCarsten BurgardAngela Maria BurgerBlake Oliver BurghgraveOleksandr BurlayenkoJared Dynes BurlesonJackson Carl BurzynskiElena Laura BuschVolker BuescherPeter John BusseyJohn Mark ButlerCraig Macleod ButtarJonathan ButterworthWill ButtingerCarlos Josue Buxo VazquezAlexey BuzykaevSusana Cabrera UrbanLuca CadamuroHuacheng CaiYuchen CaiYizhou CaiValentina CairoOrhan CakirNoemi CalacePaolo CalafiuraGiovanni CalderiniPhilippe CalfayanLara CalicGiuseppe CalleaLuiz Pereira CalobaDavid CalvetSamuel CalvetReina Coromoto Camacho ToroStefano CamardaDaniel Camarero MunozPaolo CamarriClement CamincherMario CampanelliAlessandra CamplaniVincenzo CanaleAli Can CanbayEnzo CanoneroJosu Cantero GarciaYumeng CaoFrancesca CapocasaMarcella CapuaAntonio CarboneRoberto CardarelliJuan Carlos CardenasMichael Patrick CardiffGiovandomenico CarducciTancredi CarliGiampaolo CarlinoJuan Ignacio CarlottoBen CarlsonEvan Michael CarlsonJoseph CarmignaniLeonardo CarminatiAlberto CarnelliMaria CarnesaleSascha CaronEdson Carquin LopezIsabel Beth CarrSonia CarraGiuseppe CarrattaClara Carrion MartinezAnthony Maurel CarrollPilar Casado LechugaPierluigi CasolaroMaximilian CasparFlorencia Luciana CastilloLucia Castillo GarciaVictoria Castillo GimenezNuno CastroAndrea CatinaccioJames CatmoreTom CavaliereViviana CavaliereLaura Juliana Caviedes BetancourtEmre CelebiSofia CellaVilius CepaitisKarel CernyAugusto Santiago CerqueiraAlex CerriLucio CerritoFabio CeruttiBeatrice CervatoAlberto CervelliGianmario CesariniSerkant CetinPaul Mickael ChabrillatRagansu ChakkappaiSnigdho ChakrabortyJay ChanWai Yuen ChanJohn Derek ChapmanEmilien ChaponBakar ChargeishviliDave CharltonChainika ChauhanYimin CheSergei ChekanovSergey ChekulaevG ShelkovBoping ChenCharlie ChenHuirun ChenHucheng ChenJing ChenJiayi ChenMaggie ChenShion ChenShenjian ChenXiang ChenXin ChenZhiliang ChenAlkaid ChengHok Chuen Tom ChengSanha CheongAlexander CheplakovElizaveta CherepanovaRajaa CherkaouiElliott CheuKingman CheungLaurent ChevalierVitaliano ChiarellaGiorgio ChiarelliGabriele ChiodiniAndrew Stephen ChisholmAdrian ChitanMariam ChitishviliMihail ChizhovKyungeon ChoiYuan-Tang ChouEdwin ChowMichael Kwok Lam ChuMing Chung ChuXiaotong ChuZaza ChubinidzeJiri ChudobaJanusz ChwastowskiDavide CieriKrzysztof CieslaVladimir CindroAlessandra CiocioFrancesco CirottoZvi CitronMauro CitterioDan Andrei CiubotaruAllan ClarkPhilip ClarkNoah Clarke HallCameron ClarrySavannah ClawsonChristophe ClementYann CoadouMarina CobalAndrea CoccaroRicardo BarrueRafael Coelho Lopes de SaSimone CoelliLuca Sesto ColangeliBrian Andrew ColePablo Collado SotoJohann CollotMaria Rita ColucciaPatricia Conde MuinoMatt ConnellSimon ConnellEimear Isobel ConroyMichelle Contreras CossioFrancesco ConventiAmanda SarkarLorenzo CorazzinaFederico Andrea CorchiaArtur Cordeiro Oudot ChoiLouie Dartmoor CorpeMassimo CorradiFrancois CorriveauArely Cortes-GonzalezMaria Jose Costa MezquitaFrancesco CostanzaDavide CostanzoJeremy CouthuresGlen CowanTommaso CozziKyle Stuart CranmerLucas CremerDavide CremoniniS. CrépéFrancesco CrescioliTommaso CrestaMarkus CristinzianiMarco CristoforettiVincent Alexander CroftNanni CrosettiAna Rosario Cueto GomezHanfei CuiMaxwell CuiBetsy CunnettLiam CunninghamFrancesco CurcioJennifer Rachel CurranMario SousaJoao Victor da Fonseca PintoCinzia da ViaWladyslaw DabrowskiTomas DadoSalah-Eddine DahbiTiesheng DaiDaniele Dal SantoCarlo DallapiccolaMogens DamGabriele d'AmenValerio d'AmicoJohannes Frederic DampJeff DandoyMichele d'AndreaDominik DannheimGabriele d'AnniballeMatthias DanningerValerio DaoNanni DarboSruthy Jyothi DasFilippo DattolaSaverio d'AuriaAntonio d'AvanzoTomas DavidekJoel DavidsonIan DawsonKaushik DeCarolina de Almeida RossiRiccardo de AsmundisNicola de BiaseStefano de CastroNicolo de GrootPaul de JongHector de la Torre PerezAntonio de MariaAlessandro de SalvoUmberto de SanctisFrancesco de SantisAntonella de SantoJean-Baptiste de Vivie de RegieJernej DebevcDmitri DedovichJordy DegensAllison Mccarn DeianaJose del PesoLine DelagrangeFrederic DeliotChris Malena DelitzschMassimo Della PietraDomenico Della VolpeAndrea Dell'AcquaLidia Dell'AstaMarco DelmastroClaudia Caterina DeloguPierre Antoine DelsartSarah Marie DemersMikhail DemichevSerguei DenisovHaluk DenizliLouis D'EramoDominik Karol DerendarzFrédéric DeruePaul DervanAman Mukeshbhai DesaiKlaus DeschFrancesco Armando Di BelloAnna Di CiaccioLucia Di CiaccioAntonio Di DomenicoCamilla Di DonatoAlessandro Di GirolamoGiulia Di GregorioAndrea Di LucaBiagio Di MiccoRoberto Di NardoKarri Folan Di PetrilloMagda DiamantopoulouFlavia de Almeida DiasMarco Aurelio Diaz GutierrezAlisa Romanovna DidenkoMariia DidenkoSascha Daniel DiefenbacherEdward DiehlSergio Diez CornellCarmen Diez PardosChristina DimitriadiAleksandra DimitrievskaAman DimriYuexin DingJochen Christian DingfelderThomas Benjamin DingleyIoan-Mihail DinuSebastian DittmeierFido DittusMartin DivisekBhupesh DixitFares DjamaTamar DjobavaCaterina DoglioniAdriana DohnalovaZdenek DolezalKarolina DomijanKristin DonaMarisilvia DonadelliBinbin DongJulien Noce DoniniAdelina d'OnofrioMonica d'OnofrioJens DopkeAlessandra DoriaNuno dos Santos FernandesIgo Amauri dos Santos LuzPatrick DouganMaria Teresa DovaTony DoyleMatthias Peter DrescherEtienne DreyerIoannis Drivas-KoulourisMatthew DrnevichDongshuo DuTristan Arnoldus Du PreeZonghuan DuanMathis DubauFilipp DubininMichal DubovskyEhud DuchovniGuenter DuckeckPhilippa Kathryn DuckettOtilia Anamaria DucuDominik DudaAlexey DudarevMaria Malgorzata DudekEmily Rose DudenMatteo d'UffiziLaurent DuflotMichael Duehrssen-DeblingIoana DuminicaAna Elena DumitriuMonica DunfordKatherine Elaine DunneArnaud DuperrinHatice YildizArchil DurglishviliIan DyckesMateusz DyndalBartosz Sebastian DziedzicZoe Olivia EarnshawGregor Hieronymus EberweinBarbora EckerovaStephen EggebrechtEdmar Egidio Purcino de SouzaGerald EigenKevin Frank EinsweilerTord EkelofPer Alexander EkmanSaad El FarkhYassine El GhazaliHassnae El JarrariAli El MoussaouyDoga ElitezMattias EllertFrank EllinghausTom ElliotNick EllisJohannes ElmsheuserMai ElsawyMarkus ElsingDmitry EmeliyanovYuji EnariShalini EpariDaniel Ernani Martins NetoFlorian ErnstMartin ErrenstMarc EscalierCarlos Escobar IbanezErez EtzionGuiomar Gaspar de Andrade EvansHal EvansLevi EvansAleksei EzhilovSanae EzzarqtouniFederica FabbriLaura FabbriGabriel FaciniVitaliy FadeyevRinat FakhrutdinovDionysios FakoudisSperanza FalcianoLuis Falda CoelhoFrancesco FallavollitaGregorio FalsettiJana FaltovaCunwei FanKa Yan FanYunyun FanYaquan FangMarcello FantiMohammed FarajZahra FarazpayAmir FarbinAda FarillaKiran FarmanTrisha FarooqueJesse FarrSinead FarringtonFarida FassiDimitris FassouliotisLouis FayardPavol FedericPavla FedericovaOleg FedinMatthew FeickertLorenzo FeligioniDeion Elgin FellersCunfeng FengYuan FengZhuoran FengMichael James FentonLars FerenczBeltran Fernandez BarbadilloPablo Fernandez MartinezMaxime FernouxJames FerrandoArnaud FerrariPamela FerrariRoberto FerrariDidier FerrereClaudio FerrettiMatthew FewellDavide FiaccoFrank FiedlerPetr FiedlerSergey FilimonovMatei Stefan FilipAndrej FilipcicEmily FilmerFrank FilthautMiguel Castro Nunes FiolhaisLuca FioriniWade Cameron FisherTobias FitschenPeter Michael FitzhughIvor FleckPhilipp FleischmannTobias FlickMarvin FloresLuis Roberto Flores CastilloLeyre Flores Sanz de AcedoFrancesco Maria FollegaNikolai FominJoel Hengwei FooAndrea FormicaAlessandra FortiEtienne Marie FortinAnne Winifred FortmanLiam FosterLeonidas FountasDaniel FournierHarald FoxPaolo FrancavillaSimone FrancescatoStefano FranchellucciMatteo FranchiniSilvia FranchinoDavid FrancisLuca FrancoLaura FranconiMelissa FranklinGuglielmo FrattariYuval Yitzhak FridJohnny FriendNick FritzscheAlexander FrochDaniel FroidevauxJames FrostYao FuSebastian Julio Fuenzalida GarridoMinori FujimotoKin Yip FungEduardo Furtado De Simas FilhoMarin FurukawaJuan Fuster VerduAnne GaaAlessandro GabrielliAndrea GabrielliPhilipp GadowGuido GagliardiLouis-Guillaume GagnonSafa GaidSean GalantzanJames GallagherElizabeth GallasAxel GallenBruce Joseph GallopKock Kiam GanSanmay GangulyYanyan GaoAli GarabagluFrancisca Garay WallsCarmen GarciaAndrea Garcia AlonsoArianna Gemma Garcia CaffaroJose Enrique Garcia NavarroMiguel Angel Garcia RuizMaurice Garcia-SciveresGwen Llewellyn GardnerRobert William GardnerNicoletta GarelliRocky Bala GargJack GarganChristopher Andrew GarnerCameron Michael GarveyVeritas Katharina GassmannGabriella GaudioViveka GautamPaolo GauzziJan GavranovicIgor GavrilenkoAlexander GavriliukColin Warren GayGoetz GayckenEvangelos GazisAlex GekowClaudia GemmeMarie-Helene GenestAndrew Donald GentrySimon GeorgeTheodoros GeralisAchmad Aditya GerwinPaul Gessinger-BefurtMarvin Emin GeyikMohammed GhaniKeanu GhorbanianArpan GhosalAishik GhoshAnindya GhoshBenedetto GiacobbeStefano GiaguTommaso GianiAntonio GianniniStephen GibsonMatthew GignacDamian GilAlexander Kevin GilbertBenjamin Jacob GilbertDag GillbergGeoffrey GillesDoug GingrichMapo GiordaniPierre-Francois GiraudGilberto GiugliarelliDanilo GiugniFrancesco GiuliIoannis GkialasLeonid GladilinClaudia GlasmanMarianna GlazewskaRiley Matthew GleasonGediminas GlemzaMarija GlisicIvan GnesiYeonju GoMaximilian Emanuel Goblirsch-KolbBenedikt GockeDominique GodinBerare GokturkSteven GoldfarbTobias GollingMpho Gift Doctor GololoDmitry GolubkovJason Peter GombasAgostinho da Silva GomesGabriel GomesAntonio Jesus Gomez DelegidoRicardo Jose Morais Silva GoncaloLaura GonellaAlexi GongadzeFrancesco GonnellaJulia Lynne GonskiRichards GonzalezSantiago Gonzalez de la HozMarcus Vinicius Gonzalez RodriguesRebeca Gonzalez SuarezSergio Gonzalez SevillaLuc GoossensBenedetto GoriniEdoardo GoriniAndrej GorisekThomas Christopher GosartAl GoshawMikhail GostkinSoumyananda GoswamiCarlo Alberto GottardoStefanie Andrea GotzMohamed GouighriAnna GoussiouNicolin GovenderRadoslaw Piotr GrabarczykIwona Grabowska-BoldKevin Robert GrahamEirik GramstadSergio GrancagnoloCharles Michael GrantPaul GravilaFrancesco Giuseppe GraviliHeather GrayMatteo GrecoMatthew James GreenChristian GrefeAurora Singstad GrefsrudIngrid GregorKevin Thomas GreifPhilippe GrenierSimon Gabriel GreweAlex GrilloKaty GrimmSebastian GrinsteinJean-Francois GrivazEilam GrossJoern Grosse-KnetterLiang GuanGiovanni GuerrieriRuben GuevaraRalf GugelJem Aizen Mendiola GuhitAlessandro GuidaEva GuillotonStefan GuindonFangyi GuoJun GuoLinghua GuoLei GuoYuxiang GuoAnubhav GuptaRajat GuptaShubham GuptaSaime GurbuzSimran Sunil GurdasaniGiuliano GustavinoPhillip GutierrezLuis Felipe Gutierrez ZagazetaManuel GutscheChristian GutschowClaire GwenlanCarl GwilliamEven Simonsen HaalandAndrew HaasMartin HabedankCarl HaberHaleh HadavandAbdelhamid HaddadAsma HadefAlina HaganJan Joachim HahnEmil HainesMahsana HaleemJoseph HaleyGregory HallewellKenji HamanoHassane HamdaouiMatthias HamerSalah El Dine HammoudEmily HampshireJingyi HanLiangliang HanLiang HanShuo HanKazunori HanagakiMike HanceDhanush Anil HangalHamza HanifMichael Donald HankJorgen Beck HansenPeter HansenDaigo HaradaTorsten HarenbergSiarhei HarkushaMatthew Leary HarrisYnyr HarrisJack HarrisonNatalie Marie HarrisonPaul Fraser HarrisonMax HartNicole Michelle HartmanNikolai KrugRosie HasanYoji HasegawaFlorian HaslbeckSohaib HassanReiner HauserMatej HaviernikChris HawkesRichard HawkingsYuichiro HayashiDaniel HaydenChristopher Robyn HayesRobin HayesChris HaysJonathan HaysHelen HaywardMingxu HeYajun HeYi HeNathan HeatleyVincent HedbergConstantin HeideggerKim Katrin HeideggerJesse HeilmanSarah HeimTimon HeimJochen Jens HeinrichLukas Alexander HeinrichJiri HejbalMarkus HelbigAlexander HeldSimen HellesundCole Michael HellingSten HellmanAna Maria Henriques CorreiaHannah Elizabeth HerdeYesenia Hernandez JimenezLena Maria HerrmannTim HerrmannGregor HertenRalf HertenbergerLuis HervasMoritz HespingNigel HesseyJohannes HesslerMourad HidaouiNihad HidicEwan Chin HillTarje Solberg HillersoyStephen HillierJulia Rose HindsFlorian HinterkeuserMinoru HiroseShigeki HiroseDominic HirschbuehlTom HitchingsBojan HitiJohn David HobbsRadu HobincuNoam Tal HodAnthony HodgesMark HodgkinsonBen HodkinsonAndreas HoeckerDustyn Dean HoferJudith HoferJessica HofnerMichael HolzbockBart HommelsVid HomsakBenjamin Paul HonanJae Jin HongTae Min HongBenjamin Henry HoobermanWalter HopkinsMatthew Caleb HoppeschYasuyuki HoriiMalin Elisabeth HorstmannSuen HouMason Ray HousengaJames William HowarthJoaquin HoyaMiroslav HrabovskyTetiana HrynovaPai-Hsien HsuShih-Chieh HsuTao HsuMiao HuQipeng HuShuhui HuangXinhui HuangYicong HuangYingjun HuangYanping HuangZuchen HuangZdenek HubacekFabian HueggingTodd Brian HuffmanMateus HufnagelCedrine Alexandra HugliMika HuhtinenSimon Kristian HuibertsRaphael Alain HulskenCharles Elliott HultquistDaniel Lewis HumphreysNazim HuseynovJoey HustonJohn HuthLennart HuthRachel Jordan HynemanGiuseppe IacobucciGeorge IakovidisLydia Iconomidou-FayardJames Philip IddonPaolo IengoRyunosuke IguchiYutaro IiyamaTomoya IizawaYoichi IkegamiDimitrios IliadisNikolina IlicHajar ImamGuilherme Inacio GoncalvesSebastian 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SultanLaily SultanaliyevaSalekh SultanovShaojun SunWeiyi SunNairit SurMark SuttonMichal SvatosPaul Nathaniel SwallowMaximilian J SwiatlowskiThorben SwirskiAnna SwobodaIvan SykoraMartin SykoraTomas SykoraDuc TaKerstin TackmannAnyes TaffardReda TafiroutYosuke TakuboMossadek TalbyAlexei TalyshevKai Chung TamNadav Michael TamirAoto TanakaJunichi TanakaRei TanakaMartino TanasiniZhengcheng TaoSebastian Tapia ArayaStefan TapproggeAhmed TarekShlomit TaremKhuram TariqGrigore TarnaFrancesco TartarelliMatthias Jean TartarinPetr TasMarek TasevskyEnrico TassiAric Charles TateYahya TayalatiGeoffrey Norman TaylorWendy Jane TaylorRyan James Taylor VaraAnna Sophie TegetmeierPedro Teixeira-DiasJia Jian TeohKoji TerashiJuan Terron CuadradoStefano TerzoMarianna TestaRichard TeuscherAlexander ThalerOndrej TheinerTimothee Theveneaux-PelzerDavid William ThomasJuergen ThomasEmily Anne ThompsonPaul ThompsonEvelyn Jean ThomsonRea ThornberryChunhao TianYusong TianVladimir.O TikhomirovIouri TikhonovSergei TimoshenkoDenys TimoshynEdmund Xiang Lin TingPaul Louis TiptonAbraham Tishelman-CharnyKazuki TodomeSarka TodorovaLeonardo ToffolinManabu TogawaJunji TojoStano TokarAlex ToldaievGrigorii TolkachevMakoto TomotoLauren Alexandra TompkinsEric TorrenceHeberth TorresDaniel Ignacio Torres ArzaEmma Torro PastorMariana ToscaniCecilia TosciriMarc TostDaniel ToveyThomas TrefzgerPietro Matteo TricaricoAlessandro TricoliIsabel TriggerSophie Trincaz-DuvoidDominique TrischukAnastasiia TropinaLoan TruongMaciej TrzebinskiAdam TrzupekFang-Ying TsaiMeng-Ju TsaiAngelos TsiamisPavel TsiareshkaStergios TsigaridasApostolos TsirigotisVakhtang TsiskaridzeEdisher TskhadadzeYoshiaki TsujikawaIlia TsukermanVakhtang TsulaiaSoshi TsunoKimu TsuriTsybychev Dmitri TsybyshevYanjun TuAlexandra TudoracheValentina TudoracheBaris TuncaySemen TurchikhinIlkay Turk CakirRuggero TurraTulgaa TurtuvshinMike TutsSpyros TzamariasYuma UematsuFumihiko UkegawaPablo Augusto Ulloa PobleteEjiro Naomi UmakaGuillaume UnalAlexander UndrusGokhan UnelJosef UrbanPedro UrrejolaGiulio UsaiRisa UshiodaMuhammad UsmanFuat UstunerZekeriya UysalVic VacekBrigitte VachonTheodoros VafeiadisAndrius VaitkusChrysostomos ValderanisEduardo Valdes SanturioMarco ValenteSara ValentinettiAlberto Valero BiotEnrique Valiente MorenoAlexis VallierJuan Valls FerrerDylan Remberto van ArnemanAaron van der GraafHannah van der SchyfPeter van GemmerenMilou van RijnbachSamuel van StroudIvo van VulpenPavel VanaMarco VanadiaMagdalena Vande VoordeWainer VandelliEvan Richard van de WallDamiano VannicolaLeonardo VannoliRiccardo VariMira VarmaErich Ward VarnesCarlo VarniDimitris VarouchasLorenzo VarrialeKevin VarvellMatei VasileLouis VaslinMirella Dimitrova VassilevArtem VasyukovLuke Martin VaughanRadek VavrickaTamara Vazquez SchroederJason Robert VeatchValentina VecchioMichiel Jan VeenIza VeliscekIskra VelkovskaLaurelle Maria VeloceFilipe VelosoStefano VenezianoAndrea VenturaAndrii VerbytskyiMonica VerducciChristos VergisMicael Verissimo de AraujoWouter VerkerkeJos VermeulenCaterina VernieriMakayla VessellaMichel Joseph VetterliAndreas VgenopoulosNicolas Viaux MairaTrevor VickeyOana Vickey BoeriuGeorg ViehhauserLuigi ViganiMatthias ViglMauro VillaMiguel VillaplanaElena Michelle VillhauerElisabetta VilucchiMorvan VincentManuella VincterAndrea VisibileAmbre VisiveCamilla VittoriIacopo VivarelliMariana Isabel Vivas AlbornozElena VoevodinaFabian VogelJohann Christoph VoigtPetr VokacYuriy VolkotrubLuka VombergEckhard von TorneBenedikt VormwaldKonstantin VorobevMarcel VosKatharina VossMatous VozakLubos VozdeckyNenad VranjesMarija Vranjes MilosavljevicMarcel VreeswijkNgoc Khanh VuRaphael VuillermetOlivera VujinovicIlija VukoticIshan Kiritbhai VyasJulian Friedrich WackSayaka WadaCooper WagnerJohannes Michael WagnerWolfgang WagnerShayma WahdanHernan Pablo WahlbergConnor Hilton WaitsJames William WalderRodney WalkerKatie Walkingshaw PassWolfgang WalkowiakAndie WallErik Jakob WallinTanvi WamorkarKatinka Wandall-ChristensenAonan WangAlex Zeng WangChen WangChenliang WangHaichen WangJiawei WangPeng WangPeng WangRongkun WangRui WangSong-Ming WangShudong WangTao WangTianao WangWeitao WangWei WangXiaoning WangXi WangXilin WangYuhao WangYinmiao WangZirui WangZhen WangZhichen WangChaowaroj WanotayarojAndreas WarburtonAdam Leonard WarnerbringSam WaterhouseAlan WatsonHarriet WatsonMiriam WatsonElliot WattonGordon WattsBenedict WaughJames Maitland WebbChristian WeberHannsjorg WeberMichele WeberSebastian Mario WeberChuanshun WeiYingjie WeiAnthony WeidbergEdison James WeikJens WeingartenChristian WeiserCraig John WellsTorre WenausThorsten WenglerNina Stephanie WenkeNorbert WermesMartin WesselsAndrew Mark WhartonAaron WhiteAndrew WhiteMartin John WhiteDaniel WhitesonLakmin WickremasingheWerner WiedenmannMonika WielersRenske WierdaCraig WiglesworthHenric WilkensJeremy WilkinsonDaniel WilliamsHugh WilliamsSarah Louise WilliamsStephane WillocqBenjamin James WilsonDanielle Joan Wilson-EdwardsPhilipp WindischhoferFederico WinkelFrank WinklmeierBenedict Tobias WinterMatthias WittgenMarkus WobischThomas WojtkowskiZef WolffsJulian WollrathMarcin WolterHelmut WoltersMarcus Clark WongEleanor Luise WoodwardSteven WormBarbara Krystyna WosiekKrzysztof Wieslaw WozniakSebastian WozniewskiKenneth Gibb WraightChufan WuChonghao WuJian WuMinlin WuMengqing WuSau Lan WuShaoguang WuXingyu WuJerry WuYusheng WuZhibo WuZuofei WuJonas WurzingerTerry WyattBenjamin Michael WynneStefania XellaLigang XiaMingzhe XieAnni XiongDa XuHao XuLailin XuRiley XuTairan XuYue XuZhongyukun XuRui XueBruce Donald YabsleySahal YacoobYohei YamaguchiErika YamashitaHiroki YamauchiTomohiro YamazakiYuji YamazakiSiyuan YanZhen YanHaijun YangHongtao YangSiqi YangTianyi YangXiao YangXuan YangYi-Lin YangYifan YangWei-Ming YaoCaley Luce YardleyJingbo YeShuwei YeXinmeng YeYoran YehIvan YeletskikhBeomki YeoMelissa YexleyTom Philip YildirimKohei YoritaChristopher YoungCharlie YoungNathan YoungYi YuJiarong YuanMan YuanRui YuanLuzhan YueMohamed ZaazouaBartlomiej Henryk ZabinskiImane ZahirAlessandro ZaioZuzanna Katarzyna ZakTamar ZakareishviliStefano ZambitoJilberto Zamora-SaaJiaqi ZangRiccardo ZanzotteraOta ZaplatilekChristian ZeitnitzHao ZengJiancong ZengTodd ZengerOleg ZeninTibor ZenisSeth ZenzDirk ZerwasMingjie ZhaiDengfeng ZhangGengyuan ZhangJie ZhangJinlong ZhangKaili ZhangLuxin ZhangLei ZhangPeng ZhangRui ZhangSijing ZhangTingyu ZhangYulei ZhangYuwen Ebony ZhangYangfan ZhangYixiang ZhangZhirong ZhangZhuolin ZhangZhiqing Philippe ZhangHaoran ZhaoTongbin ZhaoYuzhan ZhaoZhengguo ZhaoZihan ZhaoAlexey ZhemchugovJinchao ZhengKai ZhengXiangxuan ZhengZhi ZhengDewen ZhongBing ZhouHao ZhouNing ZhouYan ZhouYong ZhouYou ZhouChengguang ZhuJunjie ZhuXuliang ZhuYifan ZhuYingchun ZhuXuai ZhuangKonstantin ZhukovNikolai ZimineJoachim ZinsserMichal ZiolkowskiLidija ZivkovicAntonio ZoccoliKnut ZochAngelos ZografosTheodore ZorbasOlga ZormpaLukasz Zwalinski
• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie Laboratoire des deux Infinis de Toulouse AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : A search for Higgs boson pair production in the $b \overline{b} γγ$ final state is performed. The proton-proton collision dataset in this analysis corresponds to an integrated luminosity of 308 fb$^{-1}$, consisting of two samples, 140 fb$^{-1}$ at a centre-of-mass energy of 13 TeV and 168 fb$^{-1}$ at 13.6 TeV, recorded between 2015 and 2024 by the ATLAS detector at the CERN Large Hadron Collider. In addition to a larger dataset, this analysis improves upon the previous search in the same final state through several methodological and technical developments. The Higgs boson pair production cross section divided by the Standard Model prediction is found to be $μ_{HH} = 0.9^{+1.4}_{-1.1}$ ($μ_{HH} = 1^{+1.3}_{-1.0}$ expected), which translates into a 95% confidence-level upper limit of $μ_{HH}<3.8$. At the same confidence level the Higgs self-coupling modifier is constrained to be in the range $-1.7 < κ_λ< 6.6$ ($-1.8 < κ_λ< 6.9$ expected).

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• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2025
• Auteurs : Juliette QuintinAurélie Le ThuautFabienne PlouvierYoann ZerbibMichel SirodotNicholas SedillotKahaia de LongeauxAnthony Le MeurBertrand SouweineJean-Pierre QuenotJean-Claude LacheradeJulie NoublancheMickael LandaisDidier TheveninSaad NseirThomas LafonThierry VanderlindenRoland SmonigLaurent ArgaudLouis ChauvelotMarlène DuboisR. LarcherFlorian BerteauJean DellamonicaSaber Davide BarbarMathieu SerieToufik KamelFrederic JacobsNicolas de ProstJérôme DevaquetNicholas HemingMarc Pineton de ChambrunPhilippe MichelMichel DjibréAlexis FerreWalter PicardKieran PinceauxFabienne TamionFrancois LegayMaud JonasAnais CurtiaudStephan EhrmannJulien HuntzingerChristophe CraccoFrédérique SchortgenPhilippe LetocartJean Reignier
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Agen-Nérac Médecine Intensive-Réanimation [CHU Amiens] UFR de Médecine - Université de Picardie Jules Verne Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Centre Hospitalier Fleyriat [Bourg en Bresse] Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier de Cholet CHU Clermont-Ferrand Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier de Lens Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Experience ; Technology & Human Interactions ; Care & Society : Groupement des Hôpitaux de l'Institut Catholique de Lille Centre Hospitalier de Lorient Hôpital Edouard Herriot [CHU - HCL] Hospices Civils de Lyon Hôpital de la Croix-Rousse [CHU - HCL] Hospices Civils de Lyon Centre hospitalier de Montauban Centre Hospitalier Régional Universitaire [Montpellier] CH Morlaix Centre Hospitalier Universitaire de Nice Unité de Recherche Clinique Côte d’Azur Centre Hospitalier Universitaire de Nîmes Centre hospitalier territorial Gaston-Bourret [Nouméa] Centre Hospitalier Universitaire d'Orléans AP-HP - Hôpital Antoine Béclère [Clamart] Hôpital Henri Mondor Hôpital Foch [Suresnes] Hôpital Raymond Poincaré [AP-HP] Université de Versailles Saint-Quentin-en-Yvelines CHU Pitié-Salpêtrière [AP-HP] hôpital NOVO CHU Tenon [AP-HP] Centre Hospitalier de Versailles André Mignot CHU de Pau Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] CHU Rouen Hôpital de Saint-Brieuc [Hôpital Yves Le Foll] Centre hospitalier de Saint-Nazaire Hôpitaux Universitaires de Strasbourg Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Régional Universitaire de Tours Centre hospitalier Bretagne Atlantique (Morbihan) Centre Hospitalier d'Angoulême Centre Hospitalier Intercommunal de Créteil Centre hospitalier de Rodez Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Hôpital Hôtel-Dieu [CHU Nantes]
• Publié dans Critical Care le 31/10/2020

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Résumé : Background Millions of households have cats or dogs as pets, and infections due to bites or scratches are increasing, with the most common pathogens being Pasteurella spp., Bartonella spp., Capnocytophaga spp, and Francisella tularensis. The objective of this study was to describe patients admitted to the intensive care unit (ICU) for infection transmitted by cats or dogs, as well as their outcomes. Methods The retrospective multicentre observational cohort study PETSEPSIS included consecutive adults admitted to 46 ICUs in France between 2009 and 2019 for sepsis due to cat or dog bites and/or caused by any of the four above-listed bacteria. We described their features and outcomes and performed univariate and multivariate analyses to identify factors associated with death. Results We included 174 patients with a median age of 64 [50–74] years; 58.1% were male. The median SAPS II score was 42 [28–58]. Mechanical ventilation was required in 51.2% of patients, for a median duration of 7 [4–13] days. Vasopressor support was used in 53.5%, renal replacement therapy in 19%, and limb amputation in 3.6% of the patients. The median ICU length of stay was 7 [4–16] days. Hospital mortality was 24.1%. The clinical presentation and severity of sepsis were similar across bacteria, although patients with Pasteurella spp. were older and had more comorbidities. Contact with cats were more often reported for Pasteurella spp. and Bartonella spp. infections and contact with dogs for Capnocytophaga spp. infections. Risk factors for hospital mortality present on ICU admission were older age, smoking, preexisting liver disease, high serum creatinine, and anaemia. Neither the type of micro-organism nor the initial antimicrobial treatment was associated with mortality. Conclusions This large multicentre study shows that infections transmitted by cats and dogs are infrequent reasons for ICU admission but are associated with substantial morbidity and mortality. Mortality was associated with older age and comorbidities but not with the type of microorganism or initial antibiotic treatment.

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Fichiers liés : s13054-025-05558-6-2.pdf

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• Type de publi. :
• Date de publi. : 20/07/2025
• Auteurs : Jean-Philippe SarretteAndré RicardJ P GardouF. Marchal
• Organismes : Plasmas Réactifs Hors Equilibre LAboratoire PLasma et Conversion d'Energie Plasmas Réactifs Hors Equilibre

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Résumé :

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Fichiers liés : Sarrette et al_ICPIG2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 18/07/2025
• Auteurs : Aude VialatteAnaïs TibiAudrey AlignierValérie AngeonLaurent BedoussacDavid A BohanDouadia BougheraraCordeau, S.Pierre CourtoisJean-Philippe DeguineJérôme EnjalbertFrédéric FabreHélène FrévilleBenoît GrimonprezNicolas GrossMourad HannachiMarie LaunayStéphane LemariéGilles MartelMireille NavarreteManuel PlantegenestVirginie RavignéAdrien RuschFrédéric SuffertSophie ThoyerVincent Martinet
• Organismes : Dynamiques et écologie des paysages agriforestiers Direction de l'Expertise scientifique collective, de la Prospective et des Etudes Biodiversité agroécologie et aménagement du paysage Ecodéveloppement AGroécologie, Innovations, teRritoires Agroécologie [Dijon] Centre d'Economie de l'Environnement - Montpellier Agroécologie [Dijon] Centre d'Economie de l'Environnement - Montpellier Plant Health Institute of Montpellier Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Santé et agroécologie du vignoble Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Centre d’études et de coopération juridique interdisciplinaire – Université de Poitiers [UR 20418] Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR Sciences pour l'Action et le Développement : Activités, Produits, Territoires Agroclim Laboratoire d'Economie Appliquée de Grenoble Biodiversité agroécologie et aménagement du paysage Ecodéveloppement Institut de Génétique, Environnement et Protection des Plantes Peuplements végétaux et bioagresseurs en milieu tropical Santé et agroécologie du vignoble BIOlogie et GEstion des Risques en agriculture Centre d'Economie de l'Environnement - Montpellier Paris-Saclay Applied Economics
• Publié dans One Earth le 13/11/2020

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Résumé : Plant diversification at field, farm, and landscape scales is a key strategy for protecting crops from pests. But its level of adoption remains confidential, while the overall negative impacts of pesticides are now well established. To understand the obstacles to this adoption, we conducted an extensive review of literature in life and socio-economic sciences. We found that all diversification practices are largely effective in pest control, achieving satisfactory yields and many ecological cobenefits, although context dependent. Plant diversification does not appear solely as an alternative to pesticide-based pest control but as a transformative approach to achieve sustainable agrifood systems. However, its adoption is currently strongly hindered by socioeconomic barriers, including low short-term profitability, rigid agricultural sectors, and limited support from public policies. The most beneficial practices, agroforestry and diversified landscapes, face the greatest obstacles. In contrast, cultivar mixtures, while easier to implement, offer limited cobenefits. Collaboration between scientists, policymakers, and local stakeholders seems essential to scale up plant diversification.

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Fichiers liés : Vialatte et al. 2025 One Earth.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2025
• Auteurs : Julien VaidieJulien DemiselleAnthony GabrielAntoine GuillonEdwige PéjuFrédéric PènePiotr SzychowiakBoris DelangePauline GuillotJean-Claude LacheradePierre AsfarAnn ZaluckyPhilippe VignonBruno EvrardBruno François
• Organismes : Centre Hospitalier Universitaire Dupuytren 1 et 2 Nanomédecine Régénérative Centre de Recherche en Biomédecine de Strasbourg Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre Hospitalier Régional Universitaire de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Hôpital Cochin [AP-HP] Centre Hospitalier Regional d'Orléans Centre Hospitalier Universitaire [Rennes] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Départemental Vendée Centre Hospitalier Universitaire d'Angers University of Calgary Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
• Publié dans Intensive Care Medicine le 27/10/2020

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Résumé : Purpose: Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of immunosuppressive drugs > 24h) on day-90 mortality and ICU-acquired infections. Methods: This multicenter observational retrospective study conducted in solid organ transplant patients admitted to nine ICUs used a Bayesian approach with priors based on a belief elicitation process conducted among a panel of experts. Results: Among 591 enrolled patients, suspension strategy was used in 34% of them, during a median period of 5 days [IQR: 3-10]. This approach was more common in patients admitted for sepsis (38%) or COVID-19 (49%) than for non-septic causes (24%) (p < 0.001). Overall, day-90 mortality reached 30%, and Bayesian analysis revealed substantial uncertainty with an OR at 1.13 (95% Credible Interval (CrI): 0.74-1.70), and a 15% probability of a beneficial effect. In the subgroup of patients with sepsis, OR was at 0.90 (95% CrI: 0.55-1.55), with a 50% probability of a beneficial effect. ICU-acquired infections occurred in 26% of patients. The suspension strategy indicated a potential benefit, both in the entire cohort, with a 73% probability of a beneficial effect [OR: 0.74 (95% CrI: 0.49-1.15)], and in the subgroup of sepsis patients with a 78% probability of beneficial effect [OR 0.70 (95% CrI, 0.42-1.16)]. Conclusion: Temporary suspension of immunosuppressive drugs may reduce the risk of ICU-acquired infections, with a true uncertainty on day-90 mortality. Prospective studies are warranted to confirm these results.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2025
• Auteurs : Pierre BayÉtienne AudureauSlim FouratiNicolas de ProstSébastien PréauRaphaël FavoryAurélie GuigonNicholas HemingElyanne GaultTài PhamAmal ChaghouriMatthieu TurpinLaurence Morand-JoubertSébastien JochmansAurélia PitschSylvie MeirelesDamien ContouAmandine HenryAdrien JosephMarie-Laure ChaixFabrice UhelDamien RouxDelphyne DescampsMalo EmeryClaudio Garcia-SanchezDavid LevySonia BurrelJulien MayauxAntoine KimmounCedric HartardFrédéric PèneFlore RozenbergStéphane GaudrySégolène BrichlerAntoine GuillonLynda HandalaFabienne TamionAlice MoisanThomas DaixSébastien HantzFlora DelamaireV. ThibaultBertrand SouweineCecile HenquellLucile PicardFrançoise BotterelChristophe RodriguezArmand Mekontso DessapJean-Michel PawlotskyKeyvan RazaziRaphaël BellaïcheElie AzoulayJean-François TimsitGuillaume VoiriotNina de MontmollinStéphane MarotDjeneba Bocar FofanaCharles-Edouard LuytDjillali AnnaneFerhat MezianiLouis-Marie JandeauxSamira Fafi-KremerCédric DarreauJean ThominAnaïs DartevelSylvie LarratEvelyne SchvoererCédric HartardBéatrice La CombeSéverine HaouiseeSami HraeichPierre-Edouard FournierPhilippe ColsonEmmanuel CanetBerthe Marie ImbertGuillaume ThierySylvie PilletRémy CoudroyNicolas LevequeClément SaccheriValérie GiordanengoKada KloucheEdouard TuaillonCécile AubronAdissa TranJean-Marc TadiéJean-Christophe PlantierSophie Vallet
• Organismes : Centre de recherche en épidémiologie et santé des populations Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
• Publié dans Intensive Care Medicine le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2025
• Auteurs : Jean-Michel HalimiLaurent FauchierAlexandre KarrasChloé AmouyalDominique EladariPatrick RossignolGabriel ChoukrounPhilippe ZaouiNicolas GirerdSamy Hadjadj
• Organismes : Service de néphrologie et immunologie clinique [CHRU Tours] Membrane Signalling and Inflammation in reperfusion Injuries Investigation Network Initiative - Cardiovascular and Rénal Clinical Trialist Centre Hospitalier Régional Universitaire de Tours Hôpital Européen Georges Pompidou [APHP] Université Paris Cité Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Nutrition et obésités: approches systémiques (UMR-S 1269) CHU Amiens-Picardie Université de Picardie Jules Verne Paris-Centre de Recherche Cardiovasculaire Plateforme F-CRIN Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Centre Hospitalier Princesse Grace Service de Néphrologie-Dialyse-Transplantation [CHU Amiens-Picardie] HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Université Grenoble Alpes - UFR Médecine Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
• Publié dans European Journal of Preventive Cardiology le 25/10/2020

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Résumé : Chronic kidney disease (CKD) is a complex and progressive condition ultimately leading to premature death. Diabetes is the leading cause of end-stage kidney disease worldwide. Up till 2024, international clinical guidelines have established three therapeutic pillars to delay CKD progression in people with type 2 diabetes (T2D): renin-angiotensin system inhibitors, sodium-glucose cotransporter 2 inhibitors, and the non-steroidal mineralocorticoid receptor antagonist finerenone. With the recent results from the Evaluate Renal Function with Semaglutide Once Weekly (FLOW) study, the glucagon-like peptide-l receptor agonist (GLP-1 RA) class is now considered a new therapeutic pillar in reducing CKD complications in this patient population. In this expert opinion, we identify patient populations at risk of developing new onset or worsening pre-existing CKD to explore optimal therapeutic strategies, introducing GLP-1 RAs. We highlight the important challenges that remain in optimizing, sequencing, and combining these four therapeutic pillars. Even though the conventional approach of combining the pillars has been based on the historical emergence of evidence, we discuss the factors that would influence physicians’ decision for preferring one pillar over another, and for selecting a certain combination, whether performed simultaneously or sequentially. These factors include the grade of CKD and the level of albuminuria; diabetic control (glycemia); comorbidities: atherosclerotic cardiovascular disease, heart failure, obesity; concomitant medications; biological variables: potassium serum levels. The efficacy and safety profiles of each pillar, as demonstrated in landmark trials that have clearly shown the nephroprotective effects, along with real-world data, should also be carefully considered when selecting the most appropriate therapeutic option.

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Fichiers liés : zwaf426.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2025
• Auteurs : Christopher LettieriOrestis BriasoulisDamien LégerPierre‐philippe LuyetJean‐louis PépinStuart QuanJanna RaphelsonPaul SaskinAtul Malhotra
• Organismes : Hypoxie et PhysioPathologie
• Publié dans Journal of Sleep Research le 26/10/2020

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Résumé : ABSTRACT Daridorexant, a dual orexin receptor antagonist, is approved for the treatment of insomnia disorder in adults. Approximately 30%–35% of patients with insomnia disorder also have obstructive sleep apnoea (OSA) of any severity. It is unclear whether sleep medications provide safe and effective treatment for insomnia in these patients. This post hoc analysis evaluated the efficacy and safety of daridorexant 25 and 50 mg on objective and self‐reported insomnia variables and self‐reported daytime functioning in patients with untreated mild OSA and comorbid insomnia disorder (COMISA). This analysis included participants with insomnia disorder enrolled in the Phase 3 study assessing either daridorexant 25 or 50 mg with an apnoea/hypopnoea index 5–< 15 events/h (‘mild OSA’). Wake after sleep onset (WASO), latency to persistent sleep (LPS), self‐reported total sleep time (sTST) and the Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ) were assessed at Months 1 and 3. Safety endpoints were treatment‐emergent adverse events, daytime somnolence and next‐morning residual effects. In participants with mild OSA, daridorexant improved WASO, LPS, sTST and IDSIQ total score over time. The average treatment effect size for all efficacy parameters was numerically greater with daridorexant 50 mg than with daridorexant 25 mg; daridorexant 25 mg was not always greater than placebo. No safety concerns were reported for daridorexant 50 or 25 mg. In participants with comorbid insomnia and untreated mild OSA, daridorexant 50 mg versus placebo improved all sleep parameters over time and was well tolerated. Daridorexant warrants further investigation in COMISA. Trial Registration: ClinicalTrials.gov identifier: NCT03545191

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