Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 11/12/2025
• Auteurs : Rémi PiotrowskiJean-Paul LavalPierre -Marie GeffroyOlivier MassonEtienne LabordeFiras ShuaibAssil BouzidPhilippe ThomasSteve Dave Wansi WendjiMauro BoeroCarlo MassobrioGuido OriMickaël DolléDaniel ChartrandCécile GenevoisGaelle Delaizir
• Organismes : Institut de Recherche sur les CERamiques Institut de Recherche sur les CERamiques Institut de Recherche sur les CERamiques Institut de Recherche sur les CERamiques Institut de Recherche sur les CERamiques Institut de Recherche sur les CERamiques Institut de Recherche sur les CERamiques IRCER - Axe 3 : organisation structurale multiéchelle des matériaux Institut de Recherche sur les CERamiques Institut de Physique et Chimie des Matériaux de Strasbourg Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Département de chimie [UdeM-Montréal] Département de chimie [UdeM-Montréal] Conditions Extrêmes et Matériaux : Haute Température et Irradiation Institut de Recherche sur les CERamiques

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Résumé : Glasses and corresponding glass-ceramics were studied in the Na2O-V2O5-TeO2 (NVT) system. The thermal and electrical properties as well as the structure of parent glasses were determined by differential scanning calorimetry (DSC), electrochemical impedance spectroscopy measurements (EIS) and pair distribution function (PDF), respectively. The V4+/V5+ ratio in the parent glasses was estimated by X-ray photoelectron microscopy (XPS). While only one crystalline phase has been already discovered in the NVT system, this thorough experimental study evidences the stabilization of several novel crystalline phases through the glass crystallization process. An attempt to solve one of these structures is described in the present study. The glass-ceramics were produced by the spark plasma sintering (SPS) technique and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). An overall decrease of the electrical conductivity from the parent glass to its corresponding glass-ceramic is observed up to five orders of magnitude for some compositions to be related to the microstructure and the nature of the stabilized crystalline phase.

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Fichiers liés : NVT paper_november 2025.pdf

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 10/12/2025
• Auteurs : Kanta ChechiRima ChakarounAntonis MyridakisKristoffer ForslundSebastienin FromentTrine NielsenJudith Aron-WisneswkyEugeni BeldaEdi PriftiPierre Bel LassenGwen FalonySara Vieira-SilvaJulien ChillouxKazuhiro SonomuraLesley HoylesLaura Martinez-GiliFrancesco PallottiPetros AndrikopoulosFrancesc Puig-CastellvíHugo RoumeNicolas PonsEmmanuelle Le ChatelierBenoît QuinquisNathalie GalleronMagali BerlandMichael OlanipekunManyi JiaAngelos ManoliasBridget HolmesSolia AdriouchMatthias BlüherLuis CoelhoKévin Da SilvaPilar GalanBoyang JiAna NevesChristine RouaultJoe‐elie SalemValentina TremaroliTue Haldor HansenNadja SøndertoftChristian LewinterHelle Krogh PedersenPeter MarkJens GoetzeLars KøberHenrik VestergaardTorben HansenJean-Daniel ZuckerTaka-Aki SatoSerge HercbergFredrik BäckhedIvica LetunicJean-Michel OppertJens NielsenJeroen RaesIoanna TzoulakiAbbas DehghanVerena Er ZuberEmmanuelle BouzigonMark LathropParminder RainaPhillippe FroguelFumihiko MastudaFlorence DemenaisDominique GauguierMichael StumvollPeer BorkOluf PedersenStansliv Dusko Ehrlich EhrlichKarine ClémentRomina Pacheco-TapiaInés Castro-DionicioMarc-Emmanuel Dumas
• Organismes : Imperial College London University Hospital Leipzig = Universitätsklinikum Leipzig Imperial College London European Molecular Biology Laboratory [Heidelberg] MetaGenoPolis IT University of Copenhagen Nutrition et obésités: approches systémiques (UMR-S 1269) Centre de Recherche en Nutrition Humaine d'Ile-de-France Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] Nutrition et obésités: approches systémiques (UMR-S 1269) Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] Nutrition et obésités: approches systémiques (UMR-S 1269) Nutrition et obésités: approches systémiques (UMR-S 1269) CHU Pitié-Salpêtrière [AP-HP] Rega Institute for Medical Research [Leuven] VIB-KU Leuven Center for Microbiology Universitätsmedizin der Johannes Gutenberg-Universität Mainz - University Medical Center of the Johannes Gutenberg-University Mainz [Germany] Institute of Molecular Biology [Mainz, Germany] Rega Institute for Medical Research [Leuven] VIB-KU Leuven Center for Microbiology Universitätsmedizin der Johannes Gutenberg-Universität Mainz - University Medical Center of the Johannes Gutenberg-University Mainz [Germany] Institute of Molecular Biology [Mainz, Germany] Imperial College London Graduate School of Medicine and Faculty of Medicine Kyoto University Nottingham Trent University Imperial College London Università degli Studi di Enna " KORE " = Kore University of Enna Imperial College London Procédés biotechnologiques au service de l'environnement Paris-Saclay Food and Bioproduct Engineering Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 MetaGenoPolis MetaGenoPolis MetaGenoPolis MetaGenoPolis MetaGenoPolis MetaGenoPolis Imperial College London Imperial College London Imperial College London FAO Plant Production and Protection Division Nutrition et obésités: approches systémiques (UMR-S 1269) Universität Leipzig = Leipzig University University Hospital Leipzig = Universitätsklinikum Leipzig coVAPid Study Group Institut de recherche en santé, environnement et travail Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Chalmers University of Technology [Göteborg] University of Beira Interior [Portugal] Nutrition et obésités: approches systémiques (UMR-S 1269) AP-HP. Sorbonne Université Göteborgs Universitet = University of Gothenburg Københavns Universitet = University of Copenhagen = Université de Copenhague Københavns Universitet = University of Copenhagen = Université de Copenhague Novo Nordisk Foundation Center for Basic Metabolic Research Novo Nordisk Foundation Center for Basic Metabolic Research Københavns Universitet = University of Copenhagen = Université de Copenhague Københavns Universitet = University of Copenhagen = Université de Copenhague Københavns Universitet = University of Copenhagen = Université de Copenhague Novo Nordisk Foundation Center for Basic Metabolic Research Københavns Universitet = University of Copenhagen = Université de Copenhague Nutrition et obésités: approches systémiques (UMR-S 1269) Auteur indépendant Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Novo Nordisk Foundation Center for Basic Metabolic Research Biobyte Solutions GMBH Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 Imperial College London

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Résumé : Abstract Cardiometabolic diseases (CMD) are on the rise globally with one billion people expected to suffer from obesity and 643 million from type 2 diabetes by 2030, of which one-third will likely develop chronic kidney disease and two-thirds will die from cardiovascular disease (CVD). However, the mechanistic and molecular drivers of the transition from health to disease remain elusive. Here, in 275 metabolically healthy individuals recruited to the MetaCardis study, we identify a gut microbiome-kidney-heart axis that is predictive of future cardiovascular events. This axis, as evidenced by the associations between gut microbial metabolism of phenylalanine and tyrosine with variations in both kidney functon(as measured by estimated glomerular filtration rate) and circulating pro-atrial natriuretic peptide concentration, shows a depletion pattern in metabolically unhealthy participants of the MetaCardis study (n = 1,602) indicating a loss of health-sustaining microbiome features with CMD progression. We then validate that microbial compounds from the phenylalanine and tyrosine pathways and their host co-metabolites act as mediators of the gut microbiome-kidney associations. Moreover, Mendelian Randomization analysis adds genetic evidence to suggest that the microbial mediator metabolites regulate host kidney function and vice versa. Finally, we demonstrate that plasma metabolites derived from the microbial metabolism of phenylalanine and tyrosine associate with incident CVD in the Canadian Longitudinal Study on Aging (n = 8,669). Collectively, our results depict the presence of a gut microbiome-kidney-heart axis in metabolically healthy individuals. Major aberrations of the gut microbiome as part of this axis throughout life may increase risk of CVD.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 09/12/2025
• Auteurs : Rémi DieslerLaure GallayYurdagül UzunhanRaphaël BorieMartine Reynaud-GaubertVictor ValentinKaïs AhmadRomain LazorLidwine WemeauJulie TracletPierre RigaudSylvain Marchand-AdamDominique Israël-BietSandrine HirschiPhilippe BonniaudAntoine FroidureDavid MontaniJean-Marc NaccacheNicolas Romain-ScelleVincent Cottin
• Organismes : Hôpital Louis Pradel [CHU - HCL] Infections Virales et Pathologie Comparée - UMR 754 Hôpital Edouard Herriot [CHU - HCL] Hôpital Avicenne [AP-HP] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hôpital Louis Pradel [CHU - HCL] Infections Virales et Pathologie Comparée - UMR 754 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
• Publié dans Pulmonology le 04/09/2023

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Résumé : Introduction and Objectives: Risk factors of poor outcomes associated with COVID-19 are not well identified in patients with interstitial lung disease (ILD). Patients or Materials and Methods: We analysed a multicentre prospective cohort of patients with ILD and COVID-19 from January 2020 to December 2022. Risk factor analysis for death at 90 days and hospitalisation was conducted using logistic regression, adjusted for age and sex. Results: A total of 603 patients were included (66 years [54-74], 62% male). ILD diagnoses were autoimmune ILD (n = 147 [24%]), idiopathic pulmonary fibrosis (IPF, n = 124 [21%]), non-IPF fibrosing ILD (n = 118 [20%]), granulomatosis (n = 115 [19%]), exposurerelated/secondary ILD (n = 68 [11%]), and other rare lung diseases (n = 31 [5%]). Hospitalisation due to COVID-19 was associated with cardiovascular disease, cancer or haematological disease, background glucocorticoid therapy, DL CO < 40%pred and FVC < 70%pred. Death due to COVID-19 at day 90 was associated with the underlying ILD diagnosis, background glucocorticoid therapy, cardiovascular disease, cancer or haematological disease, and DL CO < 40%pred, whereas vaccination against SARS-CoV-2 was protective. COVID-19-related mortality occurred mainly in the first 90 days after SARS-CoV-2 infection. Conclusions: Poor outcomes related to COVID-19 are associated with ILD subtype and severity, background glucocorticoid therapy and absence of vaccination. There is no evidence of late mortality.

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Fichiers liés : Risk of hospitalisation and mortality among patients with interstitial lung disease and COVID-19 A French multicentre prospective cohort.pdf

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 08/12/2025
• Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatthew John AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaSonakshi AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhTorsten AkessonDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertUna Helena AlbertiPietro AlbicoccoGuillaume Lucas AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeDerrick AllenJonny AllenJulia Frances AllenCamron Stephen AlleyAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesThiziri AmezzaBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosDimitra AmperiadouShiwen AnChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanMichaela ArampatziSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaKanae AsaiSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupArnav Sunil AvadGiuseppe AvolioKonstantinos AxiotisAmir AzzamDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerPaolo BagnaiaMarzieh BahmaniDaniel BahnerKehang BaiJohn BainesLuke BainesKeith BakerEvelin BakosDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzIsaac BamwidhiElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosSergey BarsovFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosMarta Baselga BacarditSaleh BashiriAhmed BassalatMatthew Joseph BassoSusan BatajuRussell BateRichard BatesSouad BatlamousMarco BattagliaDaariimaa BattulgaMatteo BauceLukas BauckhagePatrick BauerLukas BayerTomas BazzanoJames BeachamTristan BeauJean Yves BeaucampPierre-Hugues BeaucheminPhilip BechtleHans Peter BeckKathrin BeckerAndrew BeddallVadim BednyakovChris BeeLars BeemsterMarcia BegalliMichael BegelJanna Katharina BehrJoshua Falco BeirerFlorian BeisiegelMohamed BelfkirGideon BellaLorenzo BellagambaAlain BelleriveCasey Dominik BellgraphPanagiotis BellosKonstantin BeloborodovIlyas BenaoumeurDriss BenchekrounFatima BendebbaYan BenhammouKees BenkendorferLydia Audrey BeresfordMatteo Mario BerettaElin Bergeaas KuutmannNicolas BergerBenedikt Ludwig BergmannJuerg BeringerGregorio BernardiCatrin BerniusFlorian Urs BernlochnerAdrian Berrocal GuardiaTracey BerryPeter BertaAnnalisa BertiRaphael BertrandSiegfried BethkeAlessandra BettiAdrian BevanLucas BezioNaman Kumar BhallaShudhashil BharthuarSomadutta BhattaPrajita BhattaraiZubair BhattiKartik Deepak BhideVallary Shashikant BhopatkarRiccardo Maria BianchiGianluca BiancoOtmar BiebelMichela BigliettiPim BijlSully BillingsleyYassine BimgdiMarcello BindiAnna BinghamAhmet BingulCesare BiniGareth Adam BirdMattias BirmanMarek BirosStanislav BiryukovTobias BisanzEmanuele BisceglieJyoti Prakash BiswalDiptaparna BiswasIngo BlochAndrew James BlueUlla BlumenscheinViktor BobrovnikovLucrezia BoccardoMichael BoehlerBurkhard BohmDanijela BogavacAlexander BogdanchikovLaura BoggiaVeronique BoisvertPetar BokanTomasz BoldMarco BombenMarcella BonaMaarten BoonekampAlbert Gyorgy BorbelyIurii BordulevGuennadi BorissovDaniela BortolettoDavide BoscheriniMartine Fernandez-BosmanKhalil BouaoudaNaseem BouchharLeo BoudetJoseph BoudreauEva Bouhova-ThackerDjamel Eddine BoumedieneRomain BouquetAntonio BoveiaJamie BoydDiallo BoyeIgor BoykoLeon BozianuJuraj BracinikNihal BrahimiGerhard Immanuel BrandtOleg BrandtBenjamin Paul BrauRoy Schimmel BrenerLydia BrennerRichard BrennerShikma BresslerGreta BriantiDavid BrittonDaniel BritzgerIan BrockRaymond BrockHayden BronsonGustaaf BrooijmansJammel BrooksEthan Michael BrooksLiza BrostLeesa BrownLaura Elaine BruceTim Lukas BrucklerPawel Bruckman de RenstromBen BruersAlessia BruniGraziano BruniDavid BrunnerMarco BruschiNello BruscinoTrygve BuanesQuentin BuatDaniel Alexander BuchinAndy BuckleyMaren BuhringOleg BulekovBrendon BullardSergey BurdinCarsten BurgardAngela Maria BurgerBlake Oliver BurghgraveOleksandr BurlayenkoJared Dynes BurlesonJackson Carl BurzynskiVolker BuescherPeter John BusseyOliver ButJohn Mark ButlerCraig Macleod ButtarJonathan ButterworthPierfrancesco ButtiWill ButtingerCarlos Josue Buxo VazquezAlexey BuzykaevSusana Cabrera UrbanLuca CadamuroHuacheng CaiYuchen CaiYizhou CaiValentina CairoOrhan CakirNoemi CalacePaolo CalafiuraGiovanni CalderiniPhilippe CalfayanLara CalicGiuseppe CalleaLuiz Pereira CalobaDavid CalvetSamuel CalvetReina Coromoto Camacho ToroStefano CamardaDaniel Camarero MunozPaolo CamarriClement CamincherMario CampanelliAlessandra CamplaniVincenzo CanaleAli Can CanbayEnzo CanoneroJosu Cantero GarciaYumeng CaoFrancesca CapocasaMarcella CapuaAntonio CarboneRoberto CardarelliJuan Carlos CardenasMichael Patrick CardiffGiovandomenico CarducciTancredi CarliGiampaolo CarlinoJuan Ignacio CarlottoBen CarlsonEvan Michael CarlsonLeonardo CarminatiAlberto CarnelliMaria CarnesaleSascha CaronEdson Carquin LopezIsabel Beth CarrSonia CarraGiuseppe CarrattaClara Carrion MartinezAnthony Maurel CarrollPilar Casado LechugaPierluigi CasolaroMaximilian CasparWhitmaur Robert CastiglioniFlorencia Luciana CastilloLucia Castillo GarciaVictoria Castillo GimenezNuno CastroAndrea CatinaccioJames CatmoreTom CavaliereViviana CavaliereLaura Juliana Caviedes BetancourtEmre CelebiSofia CellaVilius CepaitisKarel CernyAugusto Santiago CerqueiraAlessandro CerriLucio CerritoFabio CeruttiBeatrice CervatoAlberto CervelliGianmario CesariniSerkant CetinPaul Mickael ChabrillatRagansu ChakkappaiSnigdho ChakrabortyAidan ChambersJay ChanWai Yuen ChanJohn Derek ChapmanEmilien ChaponBakar ChargeishviliDave CharltonChainika ChauhanYimin CheSergei ChekanovG ShelkovCharlie ChenHucheng ChenJing ChenJiayi ChenMaggie ChenShion ChenShenjian ChenXiang ChenXin ChenZhiliang ChenAlkaid ChengHok Chuen Tom ChengSanha CheongAlexander CheplakovElizaveta CherepanovaElliott CheuKingman CheungLaurent ChevalierVitaliano ChiarellaGiorgio ChiarelliGabriele ChiodiniAndrew Stephen ChisholmAdrian ChitanMariam ChitishviliMihail ChizhovKyungeon ChoiYuan-Tang ChouEdwin ChowMichael Kwok Lam ChuMing Chung ChuZaza ChubinidzeJiri ChudobaJanusz ChwastowskiDavide CieriKrzysztof CieslaVladimir CindroAlessandra CiocioFrancesco CirottoZvi CitronMauro CitterioDan Andrei CiubotaruAllan ClarkPhilip ClarkNoah Clarke HallCameron ClarrySavannah ClawsonChristophe ClementLuca ClissaYann CoadouMarina CobalAndrea CoccaroRicardo BarrueRafael Coelho Lopes de SaSimone CoelliMax Michael CohenLuca Sesto ColangeliBrian Andrew ColePablo Collado SotoJohann CollotMaria Rita ColucciaPatricia Conde MuinoMatt ConnellSimon ConnellEimear Isobel ConroyMichelle Contreras CossioFrancesco ConventiAmanda SarkarLorenzo CorazzinaFederico Andrea CorchiaArtur Cordeiro Oudot ChoiLouie Dartmoor CorpeMassimo CorradiFrancois CorriveauArely Cortes-GonzalezMaria Jose Costa MezquitaFrancesco CostanzaDavide CostanzoJeremy CouthuresGlen CowanKyle Stuart CranmerLucas CremerDavide CremoniniSabine Chrystel Crepe-RenaudinFrancesco CrescioliTommaso CrestaMarkus CristinzianiMarco CristoforettiEdoardo CritelliNanni CrosettiAna Rosario Cueto GomezHanfei CuiMaxwell CuiBetsy CunnettLiam CunninghamFrancesco CurcioJennifer Rachel CurranMario SousaJoao Victor da Fonseca PintoCinzia da ViaWladyslaw DabrowskiTomas DadoSalah-Eddine DahbiTiesheng DaiDaniele Dal SantoCarlo DallapiccolaMogens DamGabriele d'AmenValerio d'AmicoJeff DandoyMichele d'AndreaDominik DannheimGabriele d'AnniballeMatthias DanningerValerio DaoNanni DarboSruthy Jyothi DasFilippo DattolaSaverio d'AuriaAntonio d'AvanzoTomas DavidekJoel DavidsonIan DawsonKaushik DeCarolina de Almeida RossiRiccardo de AsmundisNicola de BiaseStefano de CastroNicolo de GrootPaul de JongHector de la Torre PerezAntonio de MariaAlessandro de SalvoUmberto de SanctisFrancesco de SantisAntonella de SantoJean-Baptiste de Vivie de RegieJernej DebevcDmitri DedovichJordy DegensAllison Mccarn DeianaJose del PesoLine DelagrangeFrederic DeliotChris Malena DelitzschMassimo Della PietraDomenico Della VolpeAndrea Dell'AcquaLidia Dell'AstaMarco DelmastroClaudia Caterina DeloguPierre Antoine DelsartSarah Marie DemersMikhail DemichevSerguei DenisovHaluk DenizliMehul Gunvant DepalaLouis D'EramoDominik Karol DerendarzFrédéric DeruePaul DervanAman Mukeshbhai DesaiKlaus DeschFrancesco Armando Di BelloAnna Di CiaccioLucia Di CiaccioAntonio Di DomenicoCamilla Di DonatoAlessandro Di GirolamoGiulia Di GregorioAndrea Di LucaBiagio Di MiccoRoberto Di NardoKarri Folan Di PetrilloMagda DiamantopoulouFlavia de Almeida DiasMarco Aurelio Diaz GutierrezAlisa Romanovna DidenkoMariia DidenkoSascha Daniel DiefenbacherEdward DiehlSergio Diez CornellCarmen Diez PardosChristina DimitriadiAleksandra DimitrievskaAman DimriYuexin DingJochen Christian DingfelderThomas Benjamin DingleyIoan-Mihail DinuSebastian DittmeierFido DittusMartin DivisekBhupesh DixitFares DjamaTamar DjobavaCaterina DoglioniAdriana DohnalovaZdenek DolezalKarolina DomijanKristin DonaMarisilvia DonadelliBinbin DongJulien Noce DoniniAdelina d'OnofrioMonica d'OnofrioJens DopkeAlessandra DoriaNuno dos Santos FernandesIgo Amauri dos Santos LuzPatrick DouganMaria Teresa DovaTony DoyleMatthias Peter DrescherEtienne DreyerIoannis Drivas-KoulourisMatthew DrnevichDongshuo DuTristan Arnoldus Du PreeShiya DuanZonghuan DuanMathis DubauFilipp DubininMichal DubovskyEhud DuchovniGuenter DuckeckPhilippa Kathryn DuckettOtilia Anamaria DucuDominik DudaAlexey DudarevMaria Malgorzata DudekEmily Rose DudenMatteo d'UffiziLaurent DuflotMichael Duehrssen-DeblingIoana DuminicaAna Elena DumitriuMonica DunfordArnaud DuperrinHatice YildizArchil DurglishviliIan DyckesMateusz DyndalBartosz Sebastian DziedzicZoe Olivia EarnshawGregor Hieronymus EberweinBarbora EckerovaStephen EggebrechtEdmar Egidio Purcino de SouzaGerald EigenKevin Frank EinsweilerTord EkelofPer Alexander EkmanSaad El FarkhYassine El GhazaliHassnae El JarrariAli El MoussaouyIdo ElbazDoga ElitezMattias EllertFrank EllinghausTom ElliotJohannes ElmsheuserMai ElsawyMarkus ElsingDmitry EmeliyanovYuji EnariShalini EpariDaniel Ernani Martins NetoFlorian ErnstMarc EscalierCarlos Escobar IbanezRodrigo Estevam de PaulaErez EtzionGuiomar Gaspar de Andrade EvansHal EvansLevi EvansAleksei EzhilovSanae EzzarqtouniFederica FabbriLaura FabbriGabriel FaciniVitaliy FadeyevRinat FakhrutdinovDionysios FakoudisSperanza FalcianoLuis Falda CoelhoFrancesco FallavollitaGregorio FalsettiJana FaltovaCunwei FanKa Yan FanYunyun FanYaquan FangMarcello FantiMohammed FarajZahra FarazpayAmir FarbinAda FarillaKiran FarmanJesse FarrMichael Steven FarringtonSinead FarringtonFarida FassiDimitris FassouliotisLouis FayardPavol FedericPavla FedericovaOleg FedinMatthew FeickertLorenzo FeligioniDeion Elgin FellersCunfeng FengYuan FengZhuoran FengBeltran Fernandez BarbadilloPablo Fernandez MartinezMaxime FernouxJames FerrandoArnaud FerrariPamela FerrariRoberto FerrariDidier FerrereClaudio FerrettiMatthew FewellDavide FiaccoFrank FiedlerPetr FiedlerSergey FilimonovMatei Stefan FilipAndrej FilipcicEmily FilmerFrank FilthautMiguel Castro Nunes FiolhaisLuca FioriniWade Cameron FisherTobias FitschenPeter Michael FitzhughIvor FleckPhilipp FleischmannTobias FlickMarvin FloresLuis Roberto Flores CastilloMartin FollFrancesco Maria FollegaNikolai FominJoel Hengwei FooAndrea FormicaAlessandra FortiEtienne Marie FortinAnne Winifred FortmanLiam FosterLeonidas FountasHarald FoxPaolo FrancavillaSimone FrancescatoStefano FranchellucciMatteo FranchiniSilvia FranchinoDavid FrancisLuca FrancoLaura FranconiMelissa FranklinGuglielmo FrattariYuval Yitzhak FridJohnny FriendNick FritzscheAlexander FrochDaniel FroidevauxJames FrostYao FuSebastian Julio Fuenzalida GarridoMinori FujimotoKin Yip FungEduardo Furtado De Simas FilhoMarin FurukawaMax Fuste CostaJuan Fuster VerduAnne GaaAlessandro GabrielliAndrea GabrielliPhilipp GadowGuido GagliardiLouis-Guillaume GagnonSafa GaidSean GalantzanJames GallagherElizabeth GallasAxel GallenBruce Joseph GallopKock Kiam GanYanyan GaoZhanxiang GaoAli GarabagluFrancisca Garay WallsCarmen GarciaAndrea Garcia AlonsoArianna Gemma Garcia CaffaroJose Enrique Garcia NavarroMiguel Angel Garcia RuizMaurice Garcia-SciveresGwen Llewellyn GardnerRobert William GardnerNicoletta GarelliRocky Bala GargJack GarganChristopher Andrew GarnerCameron Michael GarveyVeritas Katharina GassmannGabriella GaudioViveka GautamPaolo GauzziJan GavranovicIgor GavrilenkoAlexander GavriliukColin Warren GayGoetz GayckenAlex GekowClaudia GemmeMarie-Helene GenestAndrew Donald GentrySimon GeorgeTheodoros GeralisAchmad Aditya GerwinPaul Gessinger-BefurtMohammed GhaniKeanu GhorbanianArpan GhosalAishik GhoshAnindya GhoshBenedetto GiacobbeStefano GiaguTommaso GianiAntonio GianniniStephen GibsonDamian GilAlexander Kevin GilbertBenjamin Jacob GilbertDag GillbergGeoffrey GillesDoug GingrichMapo GiordaniPierre-Francois GiraudGilberto GiugliarelliDanilo GiugniFrancesco GiuliIoannis GkialasLeonid GladilinClaudia GlasmanMarianna GlazewskaRiley Matthew GleasonGediminas GlemzaMarija GlisicIvan GnesiYeonju GoMaximilian Emanuel Goblirsch-KolbBenedikt GockeDominique GodinBerare GokturkSteven GoldfarbTobias GollingMpho Gift Doctor GololoAlex GolubDmitry GolubkovJason Peter GombasAgostinho da Silva GomesGabriel GomesAntonio Jesus Gomez DelegidoRicardo Jose Morais Silva GoncaloAlexi GongadzeFrancesco GonnellaJulia Lynne GonskiRichards GonzalezSantiago Gonzalez de la HozMarcus Vinicius Gonzalez RodriguesRebeca Gonzalez SuarezSergio Gonzalez SevillaLuc GoossensBenedetto GoriniEdoardo GoriniAndrej GorisekThomas Christopher 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SciandraGabriella SciollaSergey Alexander ScovilleFabrizio ScuriCristiano SebastianiKevin SedlaczekSally SeidelBlair Daniel SeidlitzClaudia SeitzJose SeixasGivi SekhniaidzeLuka Pierre SelemNicola Semprini CesariArtur SemushinDebajyoti SenguptaVarsha SenthilkumarLaurent SerinMarco SessaHorst SeveriniFederico SforzaAnna SfyrlaQiyu ShaHayden Michael ShaddixAashaq ShahRabia ShaheenJeff ShahinianMansoora ShamimLianyou ShanMarjorie ShapiroAbhishek SharmaAbhishek SharmaPunit SharmaSppavel ShatalovKate ShawSavanna ShawQiuping ShenDamian Joseph SheppardPeter SherwoodLiaoshan ShiXin ShiShima ShimizuIan ShipseyShohei ShirabeMariya ShiyakovaMel ShochetDavid Richard ShopeBijay ShresthaSuyog ShresthaIrina ShreyberMaheyer Jamshed ShroffPetr SichoAnne Marie SicklesElias Sideras HaddadAlexandra Claire SidleyAntonio SidotiFrank SiegertDorde SijackiFrancisco SiliJulia Manuela Cardoso SilvaIsabella Silva FerreiraMarcos Vinicius Silva OliveiraSamuel SilversteinStefan SimionRosa SimonielloEthan Lewis 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SperlichBernardino SpissoLeonardo SplendoriMartin SpoustaEzekiel StaatsRainer StamenEwa StaneckaWeronika Stanek-MaslouskaMax Vincent StangeBeojan StanislausMarcel StanitzkiJenya StarchenkoGiordon Holtsberg StarkJan StarkPavel StarobaPavel StarovoitovRafal StaszewskiCeline StauchGeorge StavropoulosAndreas SteflAnnika SteinPeter Alan SteinbergBernd StelzerJoerg StelzerOliver StelzerHasko StenzelThomas James StevensonGraeme A StewartGabriel StoiceaMarcin StolarskiStefan StonjekArno StraessnerJonas StrandbergSara StrandbergMaren StratmannMike StraussThomas StreblerPavol StrizenecRaimund StrohmerDavid StromRyszard StroynowskiAntonia StrubigStefania Antonia StucciBjarne StuguJohn StupakNicholas StylesDong SuShixiang SuXiaowen SuDaniel SuchyAthul Dev Sudhakar PonnuLion SuditYuki SueKaito SugizakiVladimir SulinD.M.S SultanLaily SultanaliyevaSalekh SultanovShaojun SunWeiyi SunSurya Sundar RamanNairit SurNathan SuriMark SuttonMichal SvatosPaul Nathaniel SwallowMaximilian J SwiatlowskiAnna SwobodaIvan SykoraMartin SykoraTomas SykoraDuc TaKerstin TackmannAnyes TaffardReda TafiroutYosuke TakuboMossadek TalbyAlexei TalyshevNadav Michael TamirAoto TanakaJunichi TanakaRei TanakaMartino TanasiniZhengcheng TaoSebastian Tapia ArayaStefan TapproggeAhmed TarekShlomit TaremKhuram TariqGrigore TarnaFrancesco TartarelliMatthias Jean TartarinPetr TasMarek TasevskyEnrico TassiAric Charles TateYahya TayalatiGeoffrey Norman TaylorWendy Jane TaylorRyan James Taylor VaraAnna Sophie TegetmeierPedro Teixeira-DiasJia Jian TeohKoji TerashiJuan Terron CuadradoStefano TerzoMarianna TestaRichard TeuscherAlexander ThalerOndrej TheinerTimothee Theveneaux-PelzerJuergen ThomasEmily Anne ThompsonPaul ThompsonEvelyn Jean ThomsonRea ThornberryChunhao TianYusong TianVladimir.O TikhomirovIouri TikhonovSergei TimoshenkoDenys TimoshynEdmund Xiang Lin TingPaul Louis TiptonAbraham Tishelman-CharnyKazuki TodomeSarka TodorovaLeonardo ToffolinManabu TogawaJunji TojoStano TokarAlex ToldaievGrigorii TolkachevMakoto TomotoLauren Alexandra TompkinsEric TorrenceHeberth TorresDaniel Ignacio Torres ArzaEmma Torro PastorMariana ToscaniCecilia TosciriMarc TostDaniel ToveyThomas TrefzgerPietro Matteo TricaricoAlessandro TricoliIsabel TriggerSophie Trincaz-DuvoidDominique TrischukAnastasiia TropinaDaniele TruncaliLoan TruongMaciej TrzebinskiAdam TrzupekFang-Ying TsaiMeng-Ju TsaiAngelos TsiamisPavel TsiareshkaStergios TsigaridasApostolos TsirigotisVakhtang TsiskaridzeEdisher TskhadadzeYoshiaki TsujikawaIlia TsukermanVakhtang TsulaiaKimu TsuriTsybychev Dmitri TsybyshevYanjun TuAlexandra TudoracheValentina TudoracheBaris TuncaySemen TurchikhinIlkay Turk CakirRuggero TurraTulgaa TurtuvshinMike TutsYuma UematsuFumihiko UkegawaPablo Augusto Ulloa PobleteGuillaume UnalAlexander UndrusJosef UrbanPedro UrrejolaGiulio UsaiRisa UshiodaMuhammad UsmanFuat UstunerZekeriya UysalVic VacekBrigitte VachonTheodoros VafeiadisAndrius VaitkusChrysostomos ValderanisEduardo Valdes SanturioMarco ValenteSara ValentinettiAlberto Valero BiotEnrique Valiente MorenoAlexis VallierJuan Valls FerrerDylan Remberto van ArnemanRomain van den BrouckeAaron van der GraafHannah van der SchyfPeter van GemmerenMilou van RijnbachSamuel van StroudIvo van VulpenPavel VanaMarco VanadiaMagdalena Vande VoordeWainer VandelliEvan Richard van de WallDamiano VannicolaLeonardo VannoliRiccardo VariMira VarmaErich Ward VarnesCarlo VarniDimitris VarouchasLorenzo VarrialeKevin VarvellMatei VasileLouis VaslinMirella Dimitrova VassilevArtem VasyukovLuke Martin VaughanRadek VavrickaTamara Vazquez SchroederJason Robert VeatchValentina VecchioMichiel Jan VeenIza VeliscekIskra VelkovskaLaurelle Maria VeloceFilipe VelosoAlex VeltmanStefano VenezianoAndrea VenturaAndrii VerbytskyiMonica VerducciChristos VergisMicael Verissimo de AraujoWouter VerkerkeJos VermeulenCaterina VernieriMakayla VessellaMichel Joseph VetterliAndreas VgenopoulosNicolas Viaux MairaTrevor VickeyOana Vickey BoeriuGeorg ViehhauserLuigi ViganiMatthias ViglMauro VillaMiguel VillaplanaElena Michelle VillhauerElisabetta VilucchiMorvan VincentManuella VincterAndrea VisibileAmbre VisiveCamilla VittoriIacopo VivarelliMariana Isabel Vivas AlbornozElena VoevodinaFabian VogelJohann Christoph VoigtPetr VokacYuriy VolkotrubLuka VombergEckhard von TorneBenedikt VormwaldKonstantin VorobevMarcel VosKatharina VossMatous VozakLubos VozdeckyNenad VranjesMarija Vranjes MilosavljevicMarcel VreeswijkNgoc Khanh VuRaphael VuillermetOlivera VujinovicIlija VukoticIshan Kiritbhai VyasJulian Friedrich WackArisa WadaSayaka WadaCooper WagnerJohannes Michael WagnerWolfgang WagnerShayma WahdanHernan Pablo WahlbergConnor Hilton WaitsJames William WalderRodney WalkerKatie Walkingshaw PassWolfgang WalkowiakAndie WallErik Jakob WallinTanvi WamorkarKatinka Wandall-ChristensenAonan WangAlex Zeng WangChen WangChenliang WangHaichen WangJiawei WangPeng WangPeng WangRongkun WangRunxuan WangRui WangSong-Ming WangShudong WangTao WangTianao WangWeitao WangXiaoning WangXi WangXilin WangYuhao WangYinmiao WangZirui WangZhen WangZhichen WangChaowaroj WanotayarojAndreas WarburtonAdam Leonard WarnerbringSam WaterhouseAlan WatsonHarriet WatsonMiriam WatsonElliot WattonGordon WattsBenedict WaughJames Maitland WebbChristian WeberMichele WeberChuanshun WeiYingjie WeiAnthony WeidbergEdison James WeikJens WeingartenChristian WeiserCraig John WellsTorre WenausThorsten WenglerNina Stephanie WenkeNorbert WermesMartin WesselsAndrew Mark WhartonAaron Stephen WhiteAndrew WhiteMartin John WhiteDaniel WhitesonLakmin WickremasingheWerner WiedenmannMonika WielersRenske WierdaCraig WiglesworthHenric WilkensJeremy WilkinsonSarah Louise WilliamsStephane WillocqBenjamin James WilsonDanielle Joan Wilson-EdwardsPhilipp WindischhoferFederico WinkelFrank WinklmeierBenedict Tobias WinterMatthias WittgenMarkus WobischThomas WojtkowskiZef WolffsJulian WollrathMarcin WolterHelmut WoltersMarcus Clark WongEleanor Luise WoodwardSteven WormBarbara Krystyna WosiekKrzysztof Wieslaw WozniakSebastian WozniewskiKenneth Gibb WraightChufan WuChonghao WuJian WuMinlin WuMengqing WuSau Lan WuShaoguang WuXingyu WuJerry WuYusheng WuZhibo WuZuofei WuJonas WurzingerTerry WyattBenjamin Michael WynneStefania XellaLigang XiaMingzhe XieAnni XiongDa XuHao XuLailin XuRiley XuTairan XuWeixi XuYue XuZhongyukun XuRui XueBruce Donald YabsleySahal YacoobYohei YamaguchiErika YamashitaHiroki YamauchiTomohiro YamazakiYuji YamazakiSiyuan YanZhen YanHaijun YangHongtao YangSiqi YangXiao YangXuan YangYi-Lin YangYifan YangWei-Ming YaoCaley Luce YardleyJingbo YeShuwei YeXinmeng YeYoran YehIvan YeletskikhBeomki YeoMelissa YexleyTom Philip YildirimKohei YoritaChristopher YoungCharlie YoungIvo YoungNathan YoungYi YuJiarong YuanMan YuanRui YuanLuzhan YueMohamed ZaazouaBartlomiej Henryk ZabinskiImane ZahirAlessandro ZaioZuzanna Katarzyna ZakTamar ZakareishviliStefano ZambitoJilberto Zamora-SaaJiaqi ZangRiccardo ZanzotteraOta ZaplatilekChristian ZeitnitzHao ZengTodd ZengerOleg ZeninTibor ZenisSeth ZenzDirk ZerwasBowen ZhangDengfeng ZhangGengyuan ZhangJie ZhangJinlong ZhangLuxin ZhangLei ZhangPeng ZhangRui ZhangSijing ZhangTingyu ZhangYulei ZhangYuwen Ebony ZhangYangfan ZhangYixiang ZhangZhirong ZhangZhuolin ZhangZhiqing Philippe ZhangHaoran ZhaoTongbin ZhaoYuzhan ZhaoZhengguo ZhaoZihan ZhaoAlexey ZhemchugovJinchao ZhengKai ZhengLu ZhengXiangxuan ZhengZhi ZhengDewen ZhongBing ZhouBai-Hong ZhouHao ZhouNing ZhouYan ZhouYong ZhouYou ZhouJunjie ZhuXuliang ZhuYifan ZhuXuai ZhuangKonstantin ZhukovNikolai ZimineJoachim ZinsserMichal ZiolkowskiLidija ZivkovicAntonio ZoccoliKnut ZochAngelos ZografosTheodore ZorbasOlga ZormpaLukasz Zwalinski
• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie Laboratoire des deux Infinis de Toulouse AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : A search for Standard Model (SM) Higgs bosons produced via vector-boson fusion at the Large Hadron Collider and decaying into a charm quark-antiquark pair ($H\rightarrow c\bar{c}$) is presented. The datasets used correspond to integrated luminosities of 37.5 fb$^{-1}$ and 51.5 fb$^{-1}$ and were collected by the ATLAS detector from proton-proton collisions at $\sqrt{s}$=13 and 13.6 TeV, respectively. The observed (expected) upper limit on the $H\rightarrow c\bar{c}$ production cross-section times branching ratio is 41 (28) times the SM prediction at 95% confidence level. Combining this search with the previous $H\rightarrow c\bar{c}$ search in associated production with a $W$ or $Z$ boson yields an observed (expected) limit on the Higgs-charm Yukawa coupling modifier of $|κ_{c}| $ < 4.7 (3.9). Higgs bosons decaying into a bottom quark-antiquark pair ($H\rightarrow b\bar{b}$) are measured simultaneously using the 51.5 fb$^{-1}$ dataset at $\sqrt{s}$=13.6 TeV, with an observed signal strength of 0.97$^{+0.57}_{-0.50}$ relative to the SM expectation. When combined with previous $H\rightarrow b\bar{b}$ results at 13 TeV, the observed (expected) significance reaches 3.2 (3.6) standard deviations, providing evidence for $H\rightarrow b\bar{b}$ events from vector-boson fusion.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/12/2025
• Auteurs : Jose Villasboas BisnetoStephen SmithDanielle WallaceJean-Pierre MarolleauCarlos Grande GarciaReid MerrymanFrancesc BoschLuca ArcainiAntonio PintoNorma GutierrezBrian TillPierre MorelRocío Figueroa MoraCristina GarcíaSara RattottiLucie AubergeonLaurent ChêneJan FagerbergPier Luigi ZinzaniPhilippe ArmandJonathan FriedbergStephen Ansell
• Organismes : Mayo Clinic [Rochester] Fred Hutchinson Cancer Research Center [Seattle] Wilmot Cancer Institute [Rochester] Service d'Hématologie Clinique et Thérapie Cellulaire [CHU Amiens] HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Universidad de Navarra [Pamplona] Dana-Farber Cancer Institute [Boston] Vall d'Hebron University Hospital [Barcelona] Fondazione IRCCS Policlinico San Matteo [Pavia] Istituto Nazionale Tumori IRCCS Fondazione G. Pascale [Naples] Instituto de Investigación Biomédica de Salamanca Service de radiothérapie [CHU Amiens] Universidad de Navarra [Pamplona] Vall d'Hebron University Hospital [Barcelona] Fondazione IRCCS Policlinico San Matteo [Pavia] Fred Hutchinson Cancer Research Center [Seattle] Fred Hutchinson Cancer Research Center [Seattle] Fred Hutchinson Cancer Research Center [Seattle] Alma Mater Studiorum Università di Bologna = University of Bologna [Bologne] Dana-Farber Cancer Institute [Boston] University of Rochester [USA] Mayo Clinic [Rochester]

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Résumé : Background Follicular lymphoma (FL) is a generally indolent disease where a watch and wait strategy is standard in asymptomatic patients (pts) with a low tumor-burden. Harnessing antitumor immunity through an anti-tumor immunization strategy at this stage may delay or avoid the subsequent need for more toxic and complex therapies. EO2463 is a therapeutic vaccine designed from non-self protein sequences, derived from gut bacteria, including 4 HLA-A2 synthetically produced 9-mer CD8 cytotoxic T cell epitopes, exhibiting molecular mimicry with specific epitopes on the B cell markers CD20, CD22, CD37, and CD268 (BAFF-receptor). Additionally, EO2463 contains a CD4 helper epitope UCP2 derived from hTERT. The compound expands pre-existing memory CD8 T cells recognizing the non-self protein sequences from gut bacteria which can then cross-react with the selected B cell antigens on tumor cells. EO2463 is being used to drive anti-tumor immunity against B cell malignancies, and has demonstrated long-lasting, specific CD8-memory T cell responses and clinical activity in relapsed/refractory FL and marginal zone lymphoma (MZL) [J Clinical Oncol 2024, 42 (S16), 7058]. Furthermore, CD8 T cells expanded from samples of patients treated with EO2463 can kill HLA-A2 expressing lymphoblastoid cell lines presenting the B cell targets [Hematological Oncol 2023, 41 (S2), 581-582]. Methods The current report describes Cohort 2 of trial EONHL1-20/SIDNEY (NCT04669171) and includes pts with newly diagnosed, previously untreated FL, grade 1-3A, HLA-A2, and not in need of treatment. Pts receive EO2463 (300μg/peptide) SC with adjuvant Montanide ISA 51 VG, q2 weeks (w) x 4, then q4w, for a total of 12 doses (39w; PET-CTs at w6, w19, and w42). Planned accrual for this cohort is 25 pts. Immune responses were assayed on thawed pt peripheral blood mononuclear cells by flow cytometry and EO2463 peptide specific tetramers or by IFN-γ ELISPOT (assaying responses against 9-mer peptides from CD20, CD22, CD37, and CD268; and from peptides of EO2463) without any proceeding in vitro stimulation (ex vivo). Results As of June 2024, 15 pts had started study treatment. Median age was 62 (range 55-66) year, 7 male and 6 female, 2 pts Ann Arbor stage I/II, 5 stage III, and 8 stage IV. Ten of 15 pts were still on treatment; median treatment duration was 18.4 weeks (range 5-39 w) for all pts. Among 13 evaluable pts, best responses by PET-CT using Lugano criteria were 1 pt CR, 5 pts PR (46% objective responses (OR)), 3 pts SD, and 4 pts PD. Of those with PD per Lugano, 2 had isolated increases in FDG-uptake without increase in lesion size/number at w6 and both remain on treatment (per protocol based on LYRIC criteria). OR was first noted w6 in 3 pts and w19 in 3 pts; duration of response is not evaluable at this time due to short follow-up. The pt with CR had isolated increases in FDG-uptake at w6, PR at w19, and CR at w35. Anti-EO2463 immune responses were observed in 4 of 5 tested pts at the 1st testing timepoint (w5) and onwards (currently longest tested up until w31). In an exploratory analysis, the percentage of EO2463 peptide specific CD8 T cells measured by tetramers seemed linked to clinical response (OR 3 pts vs non-OR 2 pts; 2-sided T-test, p=0.02; range of percentages in pts with OR 0.85%-1.39% of all CD8 T cells in peripheral blood, range in pts with non-OR 0.17%-0.27%). Functionality and cross-reactivity of responses were shown by IFN-γ ELISPOT using 9-mer peptides corresponding to the B cell targets in 4 tested pts. Expanded antigen-specific CD8 T cells displayed a memory phenotype; effector/memory (TEM), and terminally differentiated effector memory CD8 T cells (TEMRA). The most common related AEs were grade 1 (7 pts) and grade 2 (5 pts) local administration site reactions (mainly erythema, pruritus, and induration). Other related AEs in > 1 pt were grade 1 headache (2 pts) and grade 1-3 fatigue/asthenia (3 pts). Asthenia lasting 2 days was the only related grade 3 adverse event (AE). Conclusions EO2463 monotherapy is associated with a very manageable safety profile and appears to demonstrate meaningful single-agent efficacy in FL. Consistent with the preclinical hypothesis, expansion of specific CD8 memory T cells may be associated with response. Results will be expanded at the meeting. Study EONHL1-20/SIDNEY also includes cohorts, not covered in this abstract, exploring EO2463 plus rituximab for 1st line FL/MZL, and EO2463 plus lenalidomide/rituximab in relapsed FL/MZL.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 06/12/2025
• Auteurs : Cécilia BarouilletEric CapoDidier DebroasJean-Philippe JennyPierre SabatierIsabelle Domaizon
• Organismes : Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Pôle Écla - écosystèmes lacustres Umeå University = Umeå Universitet Laboratoire Microorganismes : Génome et Environnement Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Environnements, Dynamiques et Territoires de Montagne Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Pôle Écla - écosystèmes lacustres
• Publié dans Oikos le 30/10/2020

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Résumé : Microeukaryote communities ensure a large panel of ecological functions as autotrophs, predators, parasites and saprotrophs. Through the analysis of the sedimentary DNA from four peri‐alpine lakes with contrasting histories of nutrient enrichment, we reconstructed centennial‐scale ecological dynamics and assessed amplitude of change, resistance and resilience of microeukaryote communities in response to eutrophication and warming. Various biological metrics, including alpha‐ and beta‐diversity indices, and a trait‐based functional community approach were mobilized in order to depict the multi‐dimensional aspect of biodiversity changes. As the studied lakes switch from oligotrophic to meso‐oligotrophic condition, a uniform threshold response of the microeukaryote communities was observed across all lakes indicating that, in deep temperate lakes, increases in phosphorus concentration above a threshold of 10 µg l −1 , combined with declining bottom‐water oxygen conditions, can trigger early changes in the microeukaryote community, well before a lake become eutrophic. During the nutrient enrichment period, our diversity metrics indicate a decline in alpha diversity, and an increase in the turnover rate and richness difference, that might have arise from species loss. The amplitude of change in the microeukaryote community composition was lake‐dependant and not proportional to the intensity of eutrophication. Following the re‐oligotrophication of the lakes, the microeukaryote communities did not show signs of resilience. Indeed, although the communities recovered in terms of alpha diversity, the community composition did not return to pre‐disturbance composition. Instead, we observe a similar functional and structural reorganisation of the recent microeukaryote communities across all four lakes, likely driven by climate‐related processes. This multi‐metric analysis allowed to demonstrate the complex and multifaceted dimension of the biological response to environmental changes.

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Fichiers liés : 2025_Barouillet_Oikos.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 05/12/2025
• Auteurs : Pierre-Carl LanglaisAnnina ClaessonManon BerricheAndreï MogoutovJean-Philippe Cointet
• Organismes : médialab (Sciences Po) ENSAE-CREST, Institut Polytechnique de Paris médialab (Sciences Po) médialab (Sciences Po) médialab (Sciences Po)

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Résumé : We introduce Legibot, a large-scale, LLM-assisted framework for analyzing legislative debate practices in the French National Assembly during the current legislature (starting on 8 July 2024). We enrich existing frameworks like the Discourse Quality Index and adjacent deliberative-democratic scholarship and develop a rich annotation scheme that captures a range of dimensions, including tone, adherence to procedural and deliberative norms, epistemic claims, argumentative structure, emotion, and performative acts. We further train and release a lightweight supervised language model (SLM) specialized for these annotation tasks, and we deploy the fine-tuned model on the complete dataset comprising 407 126 individual sentences drawn from 149 934 speech segments. Both the annotated corpus and the SLM are made available to the research community to support reproducibility and follow-up work. Applied analyses using this multidimensional representation reveal systematic variation in justificatory practices, engagement with opponents, and affect across party lines and agenda types.The study demonstrates how theory-guided annotations, supported by LLMs, allow for bridging normative concepts coming from various visions of democracy (from deliberative to adversarial), with scalable text analysis in a core European legislature. As such, it also contributes to the current literature on the added value and limitations of generative AI in the social sciences.

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Fichiers liés : LREC_AN_bot-22.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/12/2025
• Auteurs : Gabriela MakulyteHasan Safwan‐zaiterDelphine GoehrigAnda HunaAdèle MangelinckTakumi MikawaAlberta PalazzoLyvia MoudombiJean‐jacques MedardMarie ChanalPacôme LecotMarie-Cécile MichalletJulie GavardSerge AdnotPierre DubusHiroshi KondohCarl MannNguan Soon TanPhilippe BertolinoJean‐michel FlamanDavid Bernard
• Organismes : Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Institut de Biologie Intégrative de la Cellule Graduate School of Medicine and Faculty of Medicine Kyoto University Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers Signaling in Oncogenesis, Angiogenesis and Permeability - SOAP Institut National de la Santé et de la Recherche Médicale Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre National de la Recherche Scientifique Molecular virology and immunology – Physiopathology and therapeutic of chronic viral hepatitis (Team 18) BoRdeaux Institute of onCology Graduate School of Medicine and Faculty of Medicine Kyoto University Institut de Biologie Intégrative de la Cellule Nanyang Technological University [Singapour] Institut National de la Santé et de la Recherche Médicale Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon
• Publié dans Aging Cell le 26/10/2020

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Résumé :

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Fichiers liés : Aging Cell - 2025 - Makulyte - The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A‐Dependent.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/12/2025
• Auteurs : Pierre PéfauPhilippe GardesCédric GaschyMatthieu SolerMickaël Xompero
• Organismes : Centre National de la Recherche Scientifique Institut de recherche sur l'architecture antique Institut national de recherches archéologiques préventives Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Centre d'études et de recherches archéologiques en Gascogne

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/12/2025
• Auteurs : Philippe GardesLaurent CallegarinPierre PéfauWilfried LabartheMickaël Xompero
• Organismes : Institut national de recherches archéologiques préventives Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut de recherche sur l'architecture antique Centre National de la Recherche Scientifique Institut de recherche sur l'architecture antique Archeodunum Centre d'études et de recherches archéologiques en Gascogne

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