Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 16/11/2025
• Auteurs : Yahia BelloucheCécile TromeurFlorent Le VenPhilippe RobinChristophe Gut‐gobertPierre‐yves Le RouxMichel NonentAlexandre FauchéJamal ElhasnaouiAurélia Le HirMarie GueganChristophe LeroyerPierre‐yves SalaünBastien PasdeloupRomain DidierFrancis Couturaud
• Organismes : Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier Régional Universitaire de Brest F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Groupe d'Etude de la Thrombose de Bretagne Occidentale Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Département Mathematical and Electrical Engineering Equipe Better Representations for Artificial Intelligence Groupe d'Etude de la Thrombose de Bretagne Occidentale Centre Hospitalier Régional Universitaire de Brest F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale
• Publié dans Physiological Reports le 29/10/2020

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Résumé : Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of pulmonary embolism (PE), often diagnosed late due to nonspecific symptoms and limitations of current screening tools like V/Q scintigraphy. This study investigated whether computational fluid dynamics (CFD)-derived hemodynamic parameters, specifically time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI), in the proximal pulmonary arteries could serve as noninvasive biomarkers for CTEPH and chronic thromboembolic disease without pulmonary hypertension (CTEPD, non-CTEPH with V/Q mismatches). We retrospectively analyzed 90 patients (30 CTEPH, 30 CTEPD, and 30 controls without mismatch) using patient-specific 3D CFD models reconstructed from CTPA, with RCR boundary conditions tuned to RHC data. We found significantly reduced median TAWSS in CTEPH (16.5 dyn/cm 2 ) and CTEPD (27.5 dyn/cm 2 ) groups compared to controls (42.0 dyn/cm 2 ) (p < 0.001), with TAWSS also significantly lower in CTEPH versus CTEPD. OSI showed no significant inter-group differences. Importantly, TAWSS exhibited a strong inverse correlation with V/Q mismatch status (ρ = -0.673, p < 0.001). ROC analysis revealed that TAWSS accurately predicted perfusion mismatches (AUC = 0.918), with an optimal cutoff of 27.0 dyn/cm 2 yielding 100.0% specificity and 70.0% sensitivity. These findings demonstrate that CFD-derived proximal pulmonary artery TAWSS is a promising noninvasive indicator of chronic thromboembolic burden, including subclinical perfusion abnormalities, offering a potential tool to enhance early detection and management of CTEPH.

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Fichiers liés : Physiological Reports - 2025 - Bellouche - Proximal pulmonary artery wall shear stress derived from computational fluid.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 14/11/2025
• Auteurs : Huan WangPhilippe CiaisHui YangPete SmithGiacomo GrassiClemens SchwingshacklPanos PanagosYinon Bar-OnStephen SitchFrederic ChevallierPaul PalmerXiaojun LiSongbai HongJinfeng ChangClément AlbergelSassan S SaatchiKai WangLaibao LiuFrédéric FrappartWigneron J.-P.
• Organismes : Peking University [Beijing] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Peking University [Beijing] University of Aberdeen European Commission - Joint Research Centre [Ispra] Fakultät für Physik - Ludwig-Maximilians-Universität [München/Munich] European Commission - Joint Research Centre [Ispra] California Institute of Technology University of Exeter Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation INVerse pour les mesures atmosphériques et SATellitaires The University of Edinburgh Interactions Sol Plante Atmosphère Zhejiang University [Hangzhou, China] European Centre for Space Applications and Telecommunications Southwest University [Chongqing] Peking University [Shenzhen] Institute for Atmospheric and Climate Science [Zürich] Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère
• Publié dans Nature Communications le 23/10/2020

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Résumé :

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Fichiers liés : s41467-025-64929-3.pdf

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Source

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• Type de publi. :
• Date de publi. : 10/11/2025
• Auteurs : Louis GemmerléManon LallementJean-Philippe BergerGuillermo MartinStéphane CurabaPierre Labeye
• Organismes : Institut de Planétologie et d'Astrophysique de Grenoble Institut de Planétologie et d'Astrophysique de Grenoble Institut de Planétologie et d'Astrophysique de Grenoble Institut de Planétologie et d'Astrophysique de Grenoble Institut de Planétologie et d'Astrophysique de Grenoble Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information

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Résumé : Nulling interferometry allows us to benefit from the high angular resolution provided by current ground-based (or future spatial) interferometric facilities, as well as the capability to observe exoplanets with higher planet-to-star flux ratio through coherent cancellation of the flux from the star. Using photonic integrated circuits (PIC) for the aperture recombination function has the potential to considerably improve the instrument performance : it allows the instrument to gain in compactness and thermo- mechanical stability compared to bulk optics as well as providing intrinsic self-alignment, positively impacting the nulling performance. We are currently exploring several mid-infrared technologies among which the Si/SiGe offers a great potential for the 3-9 μm domain. For that purpose we have built a dedicated four beam interferometric bench. The chosen design of this characterisation bench is composed of an association of Michelsonʼs interferometers, dividing the flux of a unique source into four beams. The coaxial aspect of this architecture provides identical pupils for all the beams, so a more uniform injection efficiency among the inputs of the nulling PIC. Moreover, in order to achieve deep null values, a stringent precision in controlling the phase, intensity and polarisation of each individual beam is required. We present the error budget established to evaluate these constraints and the characterisation of various control elements used on the bench. Monochromatic interferograms (at 3.39 μm) acquired using a preliminary version of the optical bench are presented. We analyse several sources of degradation of the experimental null value and discuss ways to mitigate them.

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Fichiers liés : POSTER_HAL.pdf

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Source

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/11/2025
• Auteurs : Julien RouzotMickaël PereiraChristian ArtiguesRomain BoyerFrédéric CampsPhilippe GarnierEmmanuel HebrardPierre Lopez
• Organismes : Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Institut de recherche en astrophysique et planétologie Équipe Énergie et Systèmes Embarqués Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Service Informatique : Développement, Exploitation et Assistance Service Informatique : Développement, Exploitation et Assistance Institut de recherche en astrophysique et planétologie Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes

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Résumé : Effective scheduling of tasks for nanosatellites is essential, given their limited onboard resources and capabilities. In a typical nanosatellite mission, the onboard computer has to run payload tasks linked to the mission objective, such as observations and measurements for science campaigns, but also communication and avionic tasks needed for navigation and safety. We consider a partitioned real-time system where a partition is a job that embeds a set of elementary tasks implementing one of the above-described functions. The offline nanosatellite partition scheduling problem consists in scheduling a set of partitions on a single core processor within a fixed time frame that will be repeated cyclically, while maximizing the number and duration of scheduled payload partitions. The paper first establishes similarities and differences with related scheduling problems. We then prove that the problem is strongly NP-hard. A Mixed Integer Linear Programming (MILP) matheuristic and a Constraint Programming (CP) model are proposed. We compare the MILP and CP approaches in a multi-objective context and demonstrate the relevance of the latter to solve the problem efficiently both on randomly generated instances and on a real nanosatellite case study of the University Space Center of Toulouse: the NIMPH project. The CP model is embedded in NanoSatScheduler, an open source software with a user interface designed for the offline nanosatellite partition scheduling problem. For the NIMPH real-case study, the proposed solution outperforms the semi-manual approach used so far. As a result, the NIMPH team has adopted NanoSatScheduler as an operational tool for their mission.

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Fichiers liés : ONPSP.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 06/11/2025
• Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczYiming AbulaitiBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatthew John AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaSonakshi AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhTorsten AkessonAndrei AkimovDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertUna Helena AlbertiPietro AlbicoccoGuillaume Lucas AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeDerrick AllenJonny AllenJulia Frances AllenPhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesThiziri AmezzaDante AmideiBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosKieran Robert AmosDimitra AmperiadouShiwen AnChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanMichaela ArampatziSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaKanae AsaiSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupArnav Sunil AvadGiuseppe AvolioKonstantinos AxiotisAmir AzzamDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerPaolo BagnaiaMarzieh BahmaniDaniel BahnerKehang BaiJohn BainesLuke BainesKeith BakerEvelin BakosDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzIsaac BamwidhiElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosSergey BarsovFalk BartelsRainer BartoldusAdam Edward 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BrauRoy Schimmel BrenerLydia BrennerRichard BrennerShikma BresslerGreta BriantiDavid BrittonDaniel BritzgerIan BrockRaymond BrockGustaaf BrooijmansJammel BrooksEthan Michael BrooksLiza BrostLeesa BrownLaura Elaine BruceTim Lukas BrucklerPawel Bruckman de RenstromBen BruersAlessia BruniGraziano BruniDavid BrunnerMarco BruschiNello BruscinoTrygve BuanesQuentin BuatDaniel Alexander BuchinAndy BuckleyOleg BulekovBrendon BullardSergey BurdinCarsten BurgardAngela Maria BurgerBlake Oliver BurghgraveOleksandr BurlayenkoJared Dynes BurlesonJackson Carl BurzynskiElena Laura BuschVolker BuescherPeter John BusseyOliver ButJohn Mark ButlerCraig Macleod ButtarJonathan ButterworthPierfrancesco ButtiWill ButtingerCarlos Josue Buxo VazquezAlexey BuzykaevSusana Cabrera UrbanLuca CadamuroHuacheng CaiYuchen CaiYizhou CaiValentina CairoOrhan CakirNoemi CalacePaolo CalafiuraGiovanni CalderiniPhilippe CalfayanLara CalicGiuseppe CalleaLuiz Pereira CalobaDavid CalvetSamuel CalvetReina Coromoto Camacho ToroStefano CamardaDaniel Camarero MunozPaolo CamarriClement CamincherMario CampanelliAlessandra CamplaniVincenzo CanaleAli Can CanbayEnzo CanoneroJosu Cantero GarciaYumeng CaoFrancesca CapocasaMarcella CapuaAntonio CarboneRoberto CardarelliJuan Carlos CardenasMichael Patrick CardiffGiovandomenico CarducciTancredi CarliGiampaolo CarlinoJuan Ignacio CarlottoBen CarlsonEvan Michael CarlsonJoseph CarmignaniLeonardo CarminatiAlberto CarnelliMaria CarnesaleSascha CaronEdson Carquin LopezIsabel Beth CarrSonia CarraGiuseppe CarrattaClara Carrion MartinezAnthony Maurel CarrollPilar Casado LechugaPierluigi CasolaroMaximilian CasparWhitmaur Robert CastiglioniFlorencia Luciana CastilloLucia Castillo GarciaVictoria Castillo GimenezNuno CastroAndrea CatinaccioJames CatmoreTom CavaliereViviana CavaliereLaura Juliana Caviedes BetancourtEmre CelebiSofia CellaVilius CepaitisKarel CernyAugusto Santiago CerqueiraAlex CerriLucio CerritoFabio CeruttiBeatrice CervatoAlberto CervelliGianmario CesariniSerkant CetinPaul Mickael ChabrillatRagansu ChakkappaiSnigdho ChakrabortyAidan ChambersJay ChanWai Yuen ChanJohn Derek ChapmanEmilien ChaponBakar ChargeishviliDave CharltonChainika ChauhanYimin CheSergei ChekanovG ShelkovBoping ChenCharlie ChenHucheng ChenJing ChenJiayi ChenMaggie ChenShion ChenShenjian ChenXiang ChenXin ChenZhiliang ChenAlkaid ChengHok Chuen Tom ChengSanha CheongAlexander CheplakovElizaveta CherepanovaRajaa CherkaouiElliott CheuKingman CheungLaurent ChevalierVitaliano ChiarellaGiorgio ChiarelliGabriele ChiodiniAndrew Stephen ChisholmAdrian ChitanMariam ChitishviliMihail ChizhovKyungeon ChoiYuan-Tang ChouEdwin ChowMichael Kwok Lam ChuMing Chung ChuXiaotong ChuZaza ChubinidzeJiri ChudobaJanusz ChwastowskiDavide CieriKrzysztof CieslaVladimir CindroAlessandra CiocioFrancesco CirottoZvi CitronMauro CitterioDan Andrei CiubotaruAllan ClarkPhilip ClarkNoah Clarke HallCameron ClarrySavannah ClawsonChristophe ClementLuca ClissaYann CoadouMarina CobalAndrea CoccaroRicardo BarrueRafael Coelho Lopes de SaSimone CoelliMax Michael CohenLuca Sesto ColangeliBrian Andrew ColePablo Collado SotoJohann CollotMaria Rita ColucciaPatricia Conde MuinoMatt ConnellSimon ConnellEimear Isobel ConroyMichelle Contreras CossioFrancesco ConventiAmanda SarkarLorenzo CorazzinaFederico Andrea CorchiaArtur Cordeiro Oudot ChoiLouie Dartmoor CorpeMassimo CorradiFrancois CorriveauArely Cortes-GonzalezMaria Jose Costa MezquitaFrancesco CostanzaDavide CostanzoJeremy CouthuresGlen CowanKyle Stuart CranmerLucas CremerDavide CremoniniSabine Chrystel Crepe-RenaudinFrancesco CrescioliTommaso CrestaMarkus CristinzianiMarco CristoforettiEdoardo CritelliVincent Alexander CroftNanni CrosettiAna Rosario Cueto GomezHanfei CuiMaxwell CuiBetsy CunnettLiam CunninghamFrancesco CurcioJennifer Rachel CurranMario SousaJoao Victor da Fonseca PintoCinzia da ViaWladyslaw DabrowskiTomas DadoSalah-Eddine DahbiTiesheng DaiDaniele Dal SantoCarlo DallapiccolaMogens DamGabriele d'AmenValerio d'AmicoJeff DandoyMichele 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FournierHarald FoxPaolo FrancavillaSimone FrancescatoStefano FranchellucciMatteo FranchiniSilvia FranchinoDavid FrancisLuca FrancoLaura FranconiMelissa FranklinGuglielmo FrattariYuval Yitzhak FridJohnny FriendNick FritzscheAlexander FrochDaniel FroidevauxJames FrostYao FuSebastian Julio Fuenzalida GarridoMinori FujimotoKin Yip FungEduardo Furtado De Simas FilhoMarin FurukawaMax Fuste CostaJuan Fuster VerduAnne GaaAlessandro GabrielliAndrea GabrielliPhilipp GadowGuido GagliardiLouis-Guillaume GagnonSafa GaidSean GalantzanJames GallagherElizabeth GallasAxel GallenBruce Joseph GallopKock Kiam GanSanmay GangulyYanyan GaoAli GarabagluFrancisca Garay WallsCarmen GarciaAndrea Garcia AlonsoArianna Gemma Garcia CaffaroJose Enrique Garcia NavarroMiguel Angel Garcia RuizMaurice Garcia-SciveresGwen Llewellyn GardnerRobert William GardnerNicoletta GarelliRocky Bala GargJack GarganChristopher Andrew GarnerCameron Michael GarveyVeritas Katharina GassmannGabriella GaudioViveka GautamPaolo GauzziJan 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Andrew SchwarzPhilippe SchwemlingReinhard SchwienhorstGianfranco SciaccaAndrea SciandraGabriella SciollaFabrizio ScuriCristiano SebastianiKevin SedlaczekSally SeidelAbraham SeidenBlair Daniel SeidlitzClaudia SeitzJose SeixasGivi SekhniaidzeLuka Pierre SelemNicola Semprini CesariArtur SemushinDebajyoti SenguptaVarsha SenthilkumarLaurent SerinMarco SessaHorst SeveriniFederico SforzaAnna SfyrlaQiyu ShaHayden Michael ShaddixAashaq ShahRabia ShaheenJeff ShahinianMansoora ShamimLianyou ShanMarjorie ShapiroAbhishek SharmaAbhishek SharmaPunit SharmaSppavel ShatalovKate ShawSavanna ShawQiuping ShenDamian Joseph SheppardPeter SherwoodLiaoshan ShiXin ShiShima ShimizuIan ShipseyShohei ShirabeMariya ShiyakovaMel ShochetDavid Richard ShopeBijay ShresthaSuyog ShresthaIrina ShreyberMaheyer Jamshed ShroffPetr SichoAnne Marie SicklesElias Sideras HaddadAlexandra Claire SidleyAntonio SidotiFrank SiegertDorde SijackiFrancisco SiliJulia Manuela Cardoso SilvaIsabella Silva FerreiraMarcos Vinicius Silva OliveiraSamuel SilversteinStefan SimionRosa SimonielloEthan Lewis SimpsonHarry SimpsonLiana SimpsonSinem SimsekSreelakshmi SindhuPekka SinervoSiddharth SinghSahibjeet SinghSupriya SinhaSukanya SinhaMaximiliano SioliKonstantinos SioulasIsmet SiralElizaveta SitnikovaJoergen SjoelinAli SkafEleni SkordaPatrick SkubicMagdalena SlawinskaIgor SlazykIevgen SliusarVladimir SmakhtinBen Harry SmartSerge SmirnovYury SmirnovLidia SmirnovaOxana SmirnovaAndrew Caldon SmithDylan Ronald SmithJames SmithMatthew Bruce SmithRachel Emma Clarke SmithHendrik SmitmannsMaria SmizanskaKarel SmolekPetr SmolyanskiyAndrei SnesarevHella SnoekRoss Matthew SnyderScott SnyderRandy SobieAbi SofferCarlos Solans SanchezEvgeny SoldatovUrmila Soldevila SerranoSanya SolodkovShalu SolomonAleksey SoloshenkoKsenia SolovievaOleg SolovyanovPhilip SommerAnil SonayAndre SopczakAlex SopioFilomena SopkovaJosef Daniel SorensonIsai Roberto Sotarriva AlvarezVarsiha SothilingamOrlando Javier Soto SandovalSimone SottocornolaRachik SoualahZainab SoumaimiDavid SouthNathalie SoybelmanStefania SpagnoloDennis SperlichBernardino SpissoDwayne SpiteriLeonardo SplendoriMartin SpoustaEzekiel StaatsRainer StamenEwa StaneckaWeronika Stanek-MaslouskaMax Vincent StangeBeojan StanislausMarcel StanitzkiJenya StarchenkoGiordon Holtsberg StarkJan StarkPavel StarobaPavel StarovoitovRafal StaszewskiCeline StauchGeorge StavropoulosAndreas SteflAnnika SteinPeter Alan SteinbergBernd StelzerJoerg StelzerOliver StelzerHasko StenzelThomas James StevensonGraeme A StewartJoshua Ryan StewartGabriel StoiceaMarcin StolarskiStefan StonjekArno StraessnerJonas StrandbergSara StrandbergMaren StratmannMike StraussThomas StreblerPavol StrizenecRaimund StrohmerDavid StromRyszard StroynowskiAntonia StrubigStefania Antonia StucciBjarne StuguJohn StupakNicholas StylesDong SuShixiang SuXiaowen SuDaniel SuchyAthul Dev Sudhakar PonnuLion SuditKaito SugizakiVladimir SulinD.M.S SultanLaily SultanaliyevaSalekh SultanovShaojun SunWeiyi SunNairit SurNathan SuriMark SuttonMichal SvatosPaul Nathaniel SwallowMaximilian J SwiatlowskiAnna SwobodaIvan SykoraMartin SykoraTomas SykoraDuc TaKerstin TackmannAnyes TaffardReda TafiroutYosuke TakuboMossadek TalbyAlexei TalyshevKai Chung TamNadav Michael TamirAoto TanakaJunichi TanakaRei TanakaMartino TanasiniZhengcheng TaoSebastian Tapia ArayaStefan TapproggeAhmed TarekShlomit TaremKhuram TariqGrigore TarnaFrancesco TartarelliMatthias Jean TartarinPetr TasMarek TasevskyEnrico TassiAric Charles TateYahya TayalatiGeoffrey Norman TaylorWendy Jane TaylorRyan James Taylor VaraAnna Sophie TegetmeierPedro Teixeira-DiasJia Jian TeohKoji TerashiJuan Terron CuadradoStefano TerzoMarianna TestaRichard TeuscherAlexander ThalerOndrej TheinerTimothee Theveneaux-PelzerDavid William ThomasJuergen ThomasEmily Anne ThompsonPaul ThompsonEvelyn Jean ThomsonRea ThornberryChunhao TianYusong TianVladimir.O TikhomirovIouri TikhonovSergei TimoshenkoDenys TimoshynEdmund Xiang Lin TingPaul Louis TiptonAbraham Tishelman-CharnyKazuki TodomeSarka TodorovaLeonardo ToffolinManabu TogawaJunji TojoStano TokarAlex ToldaievGrigorii TolkachevMakoto TomotoLauren Alexandra TompkinsEric TorrenceHeberth TorresDaniel Ignacio Torres ArzaEmma Torro PastorMariana ToscaniCecilia TosciriMarc TostDaniel ToveyThomas TrefzgerPietro Matteo TricaricoAlessandro TricoliIsabel TriggerSophie Trincaz-DuvoidDominique TrischukAnastasiia TropinaDaniele TruncaliLoan TruongMaciej TrzebinskiAdam TrzupekFang-Ying TsaiMeng-Ju TsaiAngelos TsiamisPavel TsiareshkaStergios TsigaridasApostolos TsirigotisVakhtang TsiskaridzeEdisher TskhadadzeYoshiaki TsujikawaIlia TsukermanVakhtang TsulaiaSoshi TsunoKimu TsuriTsybychev Dmitri TsybyshevYanjun TuAlexandra TudoracheValentina TudoracheBaris TuncaySemen TurchikhinIlkay Turk CakirRuggero TurraTulgaa TurtuvshinMike TutsSpyros TzamariasYuma UematsuFumihiko UkegawaPablo Augusto Ulloa PobleteEjiro Naomi UmakaGuillaume UnalAlexander UndrusGokhan UnelJosef UrbanPedro UrrejolaGiulio UsaiRisa UshiodaMuhammad UsmanFuat UstunerZekeriya UysalVic VacekBrigitte VachonTheodoros VafeiadisAndrius VaitkusChrysostomos ValderanisEduardo Valdes SanturioMarco ValenteSara ValentinettiAlberto Valero BiotEnrique Valiente MorenoAlexis VallierJuan Valls FerrerDylan Remberto van ArnemanAaron van der GraafHannah van der SchyfPeter van GemmerenMilou van RijnbachSamuel van StroudIvo van VulpenPavel VanaMarco VanadiaMagdalena Vande VoordeWainer VandelliEvan Richard van de WallDamiano VannicolaLeonardo VannoliRiccardo VariMira VarmaErich Ward VarnesCarlo VarniDimitris VarouchasLorenzo VarrialeKevin VarvellMatei VasileLouis VaslinMirella Dimitrova VassilevArtem VasyukovLuke Martin VaughanRadek VavrickaTamara Vazquez SchroederJason Robert VeatchValentina VecchioMichiel Jan VeenIza VeliscekIskra VelkovskaLaurelle Maria VeloceFilipe VelosoAlex VeltmanStefano VenezianoAndrea VenturaAndrii VerbytskyiMonica VerducciChristos VergisMicael Verissimo de AraujoWouter VerkerkeJos VermeulenCaterina VernieriMakayla VessellaMichel Joseph VetterliAndreas VgenopoulosNicolas Viaux MairaTrevor VickeyOana Vickey BoeriuGeorg ViehhauserLuigi ViganiMatthias ViglMauro VillaMiguel VillaplanaElena Michelle VillhauerElisabetta VilucchiMorvan VincentManuella VincterAndrea VisibileAmbre VisiveCamilla VittoriIacopo VivarelliMariana Isabel Vivas AlbornozElena VoevodinaFabian VogelJohann Christoph VoigtPetr VokacYuriy VolkotrubLuka VombergEckhard von TorneBenedikt VormwaldKonstantin VorobevMarcel VosKatharina VossMatous VozakLubos VozdeckyNenad VranjesMarija Vranjes MilosavljevicMarcel VreeswijkNgoc Khanh VuRaphael VuillermetOlivera VujinovicIlija VukoticIshan Kiritbhai VyasJulian Friedrich WackSayaka WadaCooper WagnerJohannes Michael WagnerWolfgang WagnerShayma WahdanHernan Pablo WahlbergConnor Hilton WaitsJames William WalderRodney WalkerKatie Walkingshaw PassWolfgang WalkowiakAndie WallErik Jakob WallinTanvi WamorkarKatinka Wandall-ChristensenAonan WangAlex Zeng WangChen WangChenliang WangHaichen WangJiawei WangPeng WangPeng WangRongkun WangRui WangSong-Ming WangShudong WangTao WangTianao WangWeitao WangWei WangXiaoning WangXi WangXilin WangYuhao WangYinmiao WangZirui WangZhen WangZhichen WangChaowaroj WanotayarojAndreas WarburtonAdam Leonard WarnerbringSam WaterhouseAlan WatsonHarriet WatsonMiriam WatsonElliot WattonGordon WattsBenedict WaughJames Maitland WebbChristian WeberMichele WeberSebastian Mario WeberChuanshun WeiYingjie WeiAnthony WeidbergEdison James WeikJens WeingartenChristian WeiserCraig John WellsTorre WenausThorsten WenglerNina Stephanie WenkeNorbert WermesMartin WesselsAndrew Mark WhartonAaron Stephen WhiteAndrew WhiteMartin John WhiteDaniel WhitesonLakmin WickremasingheWerner WiedenmannMonika WielersRenske WierdaCraig WiglesworthHenric WilkensJeremy WilkinsonDaniel WilliamsHugh WilliamsSarah Louise WilliamsStephane WillocqBenjamin James WilsonDanielle Joan Wilson-EdwardsPhilipp WindischhoferFederico WinkelFrank WinklmeierBenedict Tobias WinterMatthias WittgenMarkus WobischThomas WojtkowskiZef WolffsJulian WollrathMarcin WolterHelmut WoltersMarcus Clark WongEleanor Luise WoodwardSteven WormBarbara Krystyna WosiekKrzysztof Wieslaw WozniakSebastian WozniewskiKenneth Gibb WraightChufan WuChonghao WuJian WuMinlin WuMengqing WuSau Lan WuShaoguang WuXingyu WuJerry WuYusheng WuZhibo WuZuofei WuJonas WurzingerTerry WyattBenjamin Michael WynneStefania XellaLigang XiaMingzhe XieAnni XiongDa XuHao XuLailin XuRiley XuTairan XuWeixi XuYue XuZhongyukun XuRui XueBruce Donald YabsleySahal YacoobYohei YamaguchiErika YamashitaHiroki YamauchiTomohiro YamazakiYuji YamazakiSiyuan YanZhen YanHaijun YangHongtao YangSiqi YangTianyi YangXiao YangXuan YangYi-Lin YangYifan YangWei-Ming YaoCaley Luce YardleyJingbo YeShuwei YeXinmeng YeYoran YehIvan YeletskikhBeomki YeoMelissa YexleyTom Philip YildirimKohei YoritaChristopher YoungCharlie YoungIvo YoungNathan YoungYi YuJiarong YuanMan YuanRui YuanLuzhan YueMohamed ZaazouaBartlomiej Henryk ZabinskiImane ZahirAlessandro ZaioZuzanna Katarzyna ZakTamar ZakareishviliStefano ZambitoJilberto Zamora-SaaJiaqi ZangRiccardo ZanzotteraOta ZaplatilekChristian ZeitnitzHao ZengTodd ZengerOleg ZeninTibor ZenisSeth ZenzDirk ZerwasDengfeng ZhangGengyuan ZhangJie ZhangJinlong ZhangLuxin ZhangLei ZhangPeng ZhangRui ZhangSijing ZhangTingyu ZhangYulei ZhangYuwen Ebony ZhangYangfan ZhangYixiang ZhangZhirong ZhangZhuolin ZhangZhiqing Philippe ZhangHaoran ZhaoTongbin ZhaoYuzhan ZhaoZhengguo ZhaoZihan ZhaoAlexey ZhemchugovJinchao ZhengKai ZhengXiangxuan ZhengZhi ZhengDewen ZhongBing ZhouBai-Hong ZhouHao ZhouNing ZhouYan ZhouYong ZhouYou ZhouJunjie ZhuXuliang ZhuYifan ZhuYingchun ZhuXuai ZhuangKonstantin ZhukovNikolai ZimineJoachim ZinsserMichal ZiolkowskiLidija ZivkovicAntonio ZoccoliKnut ZochAngelos ZografosTheodore ZorbasOlga ZormpaLukasz Zwalinski
• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie Laboratoire des deux Infinis de Toulouse AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : Events with $t$-channel single top quarks are used to probe effective field theory operators in $\sqrt{s}=13$ TeV proton-proton collision data corresponding to 140 fb$^{-1}$ recorded by the ATLAS detector at the Large Hadron Collider. An analysis method leveraging Fourier techniques applied to quadruple-differential decay rates based on observables containing angular information about the decays of the top quarks is used to achieve high sensitivity. The relevant effective field theory operators are those sensitive to top-quark decay and $t$-channel production vertices. Their Wilson coefficients are tightly constrained, with results compatible with Standard Model predictions.

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• Type de publi. : Article dans une revue
• Date de publi. : 04/11/2025
• Auteurs : Pierre-Jean SileteMagdalena HouzvickovaThibault DegandKristina HugovaSébastien GodatJulien BrancheJean-Philippe RatoneFabrice CaillolMathieu PiocheJérôme RivoryArthur BergerGeoffroy VanbiervlietSarah LeblancVincent LépilliezMaximilien BarretTimothee WallenhorstAntoine DebourdeauJan MaresJérémie JacquesStephane KochLudovic CailloPhilippe Ah-SouneMarc BarthetJan MartinekJean‐michel Gonzalez
• Organismes : Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon) Institut Paoli-Calmettes Hôpital Claude Huriez [Lille] Centre de Recherche en Cancérologie de Marseille Institut Paoli-Calmettes Institut Paoli-Calmettes Hôpital Edouard Herriot [CHU - HCL] Hospices Civils de Lyon Société Française d'Endoscopie Digestive Centre Hospitalier Universitaire d'Angers Servcie Hépato-gastroentérolgie et Nutrition clinique [CHU Nice] Hôpital Cochin [AP-HP] Hôpital privé Jean Mermoz [Lyon] Hôpital privé Jean Mermoz [Lyon] Société Française d'Endoscopie Digestive Hôpital Cochin [AP-HP] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Nîmes CHU Limoges BIO-SANTÉ Service de Gastro-Entérologie [CHRU Besançon] Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse Laboratoire de Biomécanique Appliquée Hôpital Nord [CHU - APHM] Laboratoire de Biomécanique Appliquée
• Publié dans Endoscopy le 22/10/2020

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Résumé : Abstract Gastroparesis is predominantly caused by diabetes mellitus or vagal nerve injury post-surgery. About 30% of patients develop gastroparesis after esophagectomy with gastric pull-through. Standard treatments often fail, and endoscopic pyloromyotomy (G-POEM) has shown promising results. This study aimed to assess the efficacy and safety of G-POEM in patients with refractory gastroparesis after esophagectomy. A multicenter retrospective cohort study was conducted across 18 expert centers. Patients who underwent G-POEM for refractory gastroparesis following esophagectomy from August 2014 to December 2023 were included. Inclusion criteria were confirmed gastroparesis by scintigraphy, a mean Gastroparesis Cardinal Symptom Index (GCSI) of at least 1.0, and a minimum of 6 months of follow-up. The primary outcome was treatment success at 6 months, defined as a ≥50% decrease in the GCSI score. Of 113 G-POEM procedures, 108 patients (median age 65 years; 75% men) met the inclusion criteria. The primary indication for esophagectomy was adenocarcinoma (75.5%). At 6 months, 63.5% (95%CI 54.1%–72.0%) achieved clinical success, with the mean GCSI significantly decreased to 1.2 (95%CI 1.0–1.4) from 2.9 (95%CI 2.7–3.1) preprocedure. Minor adverse events occurred in 2.8% of cases. Long-term follow-up showed sustained efficacy with success rates of 54.9% and 66.1% at 12 and 24 months, respectively. G-POEM appears to be a safe and effective treatment for refractory gastroparesis in post-esophagectomy patients, achieving significant symptom relief in the majority of patients. Future prospective studies are necessary to further validate these findings and explore predictive factors for treatment success.

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• Type de publi. : Article dans une revue
• Date de publi. : 03/11/2025
• Auteurs : Stephen SmithFrancesc Bosch AlbaredaDanielle WallaceJose Villasboas BisnetoCarlos GrandeJean-Pierre MarolleauReid MerrymanLuca ArcainiAntonio PintoNorma GutiérrezBrian TillCristina García HerceMaria Rocio Figueroa MoraPierre MorelSara RattottiPhilippe RinaudoJean-Marie CarpierJan FagerbergPier Luigi ZinzaniPhilippe ArmandJonathan FriedbergStephen Ansell
• Organismes : Fred Hutchinson Cancer Research Center [Seattle] Wilmot Cancer Institute [Rochester] Mayo Clinic [Rochester] Universidad de Navarra [Pamplona] CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Dana-Farber Cancer Institute [Boston] Fondazione IRCCS Policlinico San Matteo [Pavia] Istituto Nazionale Tumori IRCCS Fondazione G. Pascale [Naples] Instituto de Investigación Biomédica de Salamanca Fred Hutchinson Cancer Research Center [Seattle] Service de radiothérapie [CHU Amiens] Fondazione IRCCS Policlinico San Matteo [Pavia] Yale University [New Haven] Fred Hutchinson Cancer Research Center [Seattle] Alma Mater Studiorum Università di Bologna = University of Bologna [Bologne] Dana-Farber Cancer Institute [Boston]
• Publié dans Blood le 28/10/2020

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Résumé : Background Single-agent R is a common 1st-line therapy for patients (pts) with FL, especially those with low-tumor burden advanced stage disease or comorbidities. EO is a therapeutic vaccine generated from non-self-protein sequences from gut bacteria, including 4 HLA-A2 CD8 T cell epitopes that mimic B cell-specific markers: CD20, CD22, CD37 and BAFF-receptor. EO also contains a CD4 helper epitope UCP2. EO expands pre-existing memory CD8 T cells recognizing non-self-protein sequences from gut bacteria which can cross-react with B cell antigens on tumor cells. The aim adding EO to R is to safely increase the depth and duration of responses. Methods Cohort 3 (C3) of trial EONHL1-20/SIDNEY includes pts with HLA-A2 and previously untreated low-tumor burden (GELF) FL grade 1-3A in need of treatment (per pt/treating physician). Pts receive EO (300μg/peptide) SC with adjuvant Montanide, q2 weeks (w) x 4, then q4w for a total of 12 doses, combined with R starting at w7 (375 mg/m2 IV q1w x4, then q8w x4). For immune responses blood mononuclear cells were assayed by flow cytometry and EO-mimic or B cell peptide specific tetramers without in vitro stimulation. The primary objective is to assess safety; secondary objectives include EO immunogenicity and preliminary efficacy. Results As of July 2025, the 6 planned pts had started EO. Median age was 66 years (range 46-73); 5 ECOG 0/1 ECOG 1; 1 Ann Arbor stage III/5 stage IV; FLIPI low risk 2/intermediate 2/high 2; FLIPI-2 low risk 2/intermediate 4. At median follow-up 10.6 months (mo) 4 pts completed and 2 are ongoing on EO. Median treatment duration was 43 w (range 2-43). Best response by Lugano in the 6 pts included 4 complete (CR) and 2 partial responses (PR). Median time to PR/CR was 17.1 w (range 6.0-18.0). Currently there is only 1 (not yet confirmed) progression at 20.5 mo. All 5 immune response evaluable pts had expansion of CD8 T cells specific for EO mimic and B cell target peptides during treatment; 4 of 5 had detectable expansions at w5 (1st testing time). Currently, the longest tested immune response is at w65 and positive for both EO mimic and B cell target peptides. Expanded specific CD8 T cells had a memory phenotype predominantly composed of effector memory (TEM) cells but also including central memory (TCM) and terminally differentiated effector memory CD8 T (TEMRA) cells. Across the 5 pts, the medians of max % (sum of specific CD8 T cells targeting either the 4 EO mimic peptides or the 4 B cell antigen epitopes at a specific timepoint) among all peripheral CD8 T cells were 0.71% (range 0.19-3.97) for EO mimic and 0.33% (0.20-1.30) for B cell target peptides. The most common EO-related adverse events (AEs) were local administration site reactions (erythema, pain, induration). These included Gr (Grade) 1 reactions in 3 pts, Gr 2 in 1 pt, and Gr 3 in 1 pt; latter being ulceration with EO-interruption at w10.1, and in context of a strong immune response against EO mimic [3.97% of all peripheral CD8 T cells at w5] and B cell target [1.30%] peptides, and CR from w16.7. Other EO related AEs were Gr 1 lymph node pain (1 pt), and related to both EO and R were Gr 2 urticaria (1 pt) and Gr 1 fatigue (1 pt). Only R related were Gr 2 infusion related reaction (3 pts), Gr 2 enterocolitis infection (1 pt), and in 1 pt each Gr 1 flushing, anemia, headache and diarrhea. There were no further Gr 3-4 AE and no death on treatment/follow-up. Complete B cell depletion was seen in 5 pts tested at w18 (R added w7); no recovery in the range of w30-65. Only 3 infections were reported, per above enterocolitis, and 2 cases of COVID-19 both resolved without sequalae. ConclusionsThe combination of EO with R has a predictable and manageable safety profile, with EO only adding local administration site reactions to the well-known R safety profile. In this feasibility cohort all evaluable pts developed a specific immune response against EO and B cell targets, and a Lugano objective response. The combination of EO and R is feasible and can be evaluated in further trials. Updated results will be presented at the meeting.

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• Type de publi. : Article dans une revue
• Date de publi. : 03/11/2025
• Auteurs : Arthur BobinJérôme LambertJill CorreSalomon ManierAurore PerrotLionel KarlinMurielle RousselNoémie BigotKamel LaribiClaire DingremontChristophe RoulValentine RichezClara MarietteSophie RigaudeauClaire CalmettesMamoun DibMourad TiabLaure VincentJacques DelaunayJean-Pierre MarolleauPascal GodmerAnaïs SchavgoulidzeLaurent FrenzelRonan Le CallochÉmilie ChalayerHélène GardeneyMagaret MacroBruno RoyerStéphanie HarelOlivier DecauxBertrand ArnulfKarim Belhadj MerzougCyrille TouzeauMohamad MohtyPhilippe MoreauThierry FaconCyrille HulinXavier Leleu
• Organismes : Ischémie reperfusion, métabolisme et inflammation stérile en transplantation [U 1313] Epidemiology and Clinical Statistics for Tumor, Respiratory, and Resuscitation | Epidémiologie Clinique, STatistique, pour la Recherche en Santé Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) Centre de Recherches en Cancérologie de Toulouse Université de Lille Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Recherches en Cancérologie de Toulouse Institut de Cancérologie des Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] CHU Limoges Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) Hopital Saint-Louis [AP-HP] Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier de Bigorre [Tarbes] Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Centre Hospitalier Universitaire de Nice CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier de Versailles André Mignot Université de Versailles Saint-Quentin-en-Yvelines Centre Hospitalier de Périgueux Centre Hospitalier Universitaire d'Angers Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Hôpital Saint Eloi [CHU Montpellier] Hôpital privé du Confluent [Nantes] CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Centre hospitalier Bretagne Atlantique (Morbihan) Service Hématologie - IUCT-Oncopole [CHU Toulouse] Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Centre hospitalier de Cornouaille Quimper Concarneau [Quimper] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hopital Saint-Louis [AP-HP] Groupe Henri Mondor-Albert Chenevier Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Bordeaux Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
• Publié dans Blood le 28/10/2020

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Résumé : Introduction: Sustained minimal residual disease (sMRD) negativity has shown a stronger correlation with survival outcomes than MRD negativity at a single time point or at best response. We evaluated MRD negativity between 12 and 24 months in newly diagnosed multiple myeloma (NDMM) transplant-ineligible (TI) patients enrolled in the BENEFIT study. Methods: BENEFIT is a multicenter, phase 3 randomized trial comparing isatuximab-lenalidomide-dexamethasone with or without bortezomib (Isa-Rd ± V) in NDMM TI patients. In the Isa-VRd arm, bortezomib (V) was administered weekly for up to 18 months, dexamethasone was permanently discontinued after 12 months, and isatuximab-lenalidomide (Isa-R) was continued until progression. Data are presented in the intention-to-treat (ITT) population. Results: With a median follow-up of 33.4 months (95% CI, 33.0–34.0), 78 patients (29%) discontinued treatment, primarily due to progressive disease. At 24 months, the MRD negativity rate at 10⁻⁵ was significantly higher in the Isa-VRd arm (odds ratio [OR] 2.26; 95% CI, 1.35–3.79; p=0.002). Sustained MRD negativity at 10⁻⁵ was also more frequent in the Isa-VRd arm (OR 2.73; 95% CI, 1.50–4.80; p=0.0007). Similar results were observed for sMRD at the 10⁻⁶ threshold. Importantly, MRD negativity at both 10⁻⁵ and 10⁻⁶ was evaluated in the t(11;14) NDMM TI subgroup. In this subgroup, MRD negativity rates were consistently lower at all time points up to 24 months, consistent with recent observations from the MIDAS study. Due to the small number of patients per group, no subgroup-specific analysis was feasible. Larger cohorts are required to determine whether t(11;14) MM in TI patients achieves delayed or less frequent MRD negativity, potentially reflecting a MGUS-like phenotype. No new safety signals were observed in either treatment arm, including in high-risk multiple myeloma (HRMM) patients. Conclusion: The BENEFIT study continues to support the efficacy of the quadruplet Isa-VRd regimen in NDMM TI patients, notably through improved sustained MRD negativity rates. These data support Isa-VRd as a new standard of care (SOC) for NDMM TI patients aged 65–79 years, including those with HRMM. ClinicalTrials.gov Identifier: NCT04751877

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• Type de publi. : Article dans une revue
• Date de publi. : 03/11/2025
• Auteurs : Jose Villasboas BisnetoReid MerrymanStephen SmithDanielle WallaceJean-Pierre MarolleauLuca ArcainiCarlos GrandeFrancesc Bosch AlbaredaAntonio PintoNorma GutiérrezBrian TillMaria Rocio Figueroa MoraPierre MorelSara RattottiCristina García HercePhilippe RinaudoJean-Marie CarpierJan FagerbergPier Luigi ZinzaniJonathan FriedbergPhilippe ArmandStephen Ansell
• Organismes : Mayo Clinic [Rochester] Dana-Farber Cancer Institute [Boston] Fred Hutchinson Cancer Research Center [Seattle] Wilmot Cancer Institute [Rochester] CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Fondazione IRCCS Policlinico San Matteo [Pavia] Universidad de Navarra [Pamplona] Istituto Nazionale Tumori IRCCS Fondazione G. Pascale [Naples] Instituto de Investigación Biomédica de Salamanca Fred Hutchinson Cancer Research Center [Seattle] Service de radiothérapie [CHU Amiens] Fondazione IRCCS Policlinico San Matteo [Pavia] Yale University [New Haven] Fred Hutchinson Cancer Research Center [Seattle] Alma Mater Studiorum Università di Bologna = University of Bologna [Bologne] University of Rochester [USA]
• Publié dans Blood le 28/10/2020

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Résumé : Background Watchful waiting is a common option for pts with asymptomatic FL/MZL. Anti-tumor immunization may delay or even avoid subsequent need for more toxic therapies. EO is designed from non-self-protein sequences derived from gut bacteria, including 4 HLA-A2 CD8 T cell epitopes (synthetic mimic peptides), exhibiting molecular mimicry with specific epitopes on B cell markers (CD20, CD22, CD37, BAFF-receptor). EO also contains a CD4 helper epitope UCP2. EO expands pre-existing memory CD8 T cells recognizing non-self-epitopes from gut bacteria that cross-react with B cell antigens on tumor cells. Methods Cohort 2 (C2; planned accrual 25 pts) of EONHL1-20/SIDNEY includes HLA-A2+ pts with previously untreated FL/MZL not in need of treatment. Pts receive EO (300μg/peptide) SC with adjuvant Montanide, q2 weeks (w) x 4, then q4w, for 12 total doses. For antigen-specific immune responses, peripheral blood mononuclear cells were assayed by flow cytometry using EO-mimic or B cell peptide specific tetramers without in vitro stimulation. IFN-γ ELISPOT was used to evaluate response to UCP2 and anti-CD3. Primary endpoint is objective response rate (ORR) per Lugano 2014. A pre-defined futility boundary was applied (ORR uninteresting=5%/promising=20%). Finding at least 3 of 25 pts with ORR would meet criteria to continue development (chance of 13% and 90% for true ORR of 5% and 20%, respectively). Results As of July 2025, 22 pts had started EO. Median age 59 years (range 32-86); 9 female; 19 ECOG 0/3 ECOG 1; 19 FL/3 extranodal MZL (ENMZL); 3 Ann Arbor stage I-II/8 stage III/11 stage IV; FLIPI low risk 8/intermediate 8/high 6; FLIPI-2 low risk 12/intermediate 7/high 3; 19 GELF neg/3 pos. At a median follow-up for progression of 9.4 months, 9 pts completed EO, 4 stopped for progressive disease (PD), 2 due to PI/pt decision; 7 ongoing. Median treatment duration 38 w (range 4-39). Among 19 evaluable pts, best Lugano response was 3 complete (CR) and 6 partial responses (PR) (ORR 47% [95% CI 24%–71%]; CR-rate 16% [3%-40%]), 6 stable disease (SD), and 4 PD. ORR by PET-CT was 29% (n=14) w6, 39% (n=18) w19, 46% (n=13) w42; corresponding CR rates were 0%, 11%, 15%. Median time to response 17.1 w (range 5.3-41.1). Currently there are only 2 confirmed PD events in pts with prior PR/CR. Among 8 pts with an initial indeterminate response per LyRIC 2016 followed by a confirmatory scan, 4 pts did not have confirmed PD; a possible atypical response pattern rate of 50% on EO (occurring 5.3-41.9 w after start of EO). In 16 immune response evaluable pts, 88% and 81% had expansion of CD8 T cells specific for EO mimic and B cell target peptides, respectively. Expanded specific CD8 T cells had a memory phenotype dominated by effector memory (TEM) and central memory cells. At w5, 7 clinical responders and 7 non-responders were evaluable; more responders had a positive immune response against EO mimic (Chi-square p=0.025) and B cell target (p=0.047) peptides. Max expansion (response sum for 4 EO mimic or 4 B cell target peptides at a single timepoint w3-w8) of specific CD8 T cells (% of all peripheral CD8 T cells) was higher for responders than non-responders both for EO mimic (Mann Whitney p=0.018) and B cell target (p=0.017) peptides. Pts (4) with an initial indeterminate response (LyRIC 2016) had a higher max expansion of B cell target peptide specific CD8 T cells vs 4 pts with a typical progression pattern (Mann Whitney p=0.018) and vs all other 12 pts evaluable for immune response (p=0.029). There was no difference in CD4 T cell response to UCP2 in responders vs non-responders (induction or max immunity w3-w8). Anti-CD3 expansion of T cells indicating T cell intrinsic activation potential did not correlate with clinical response (baseline or max). The most common EO-related adverse events (AEs) were Gr (Grade) 1 (10 pts) and Gr 2 (6 pts) local administration site reactions. Other related AEs in >1 pt were Gr 1 headache (3 pts) and Gr 1-2 fatigue (3 pts). Asthenia lasting 2 days was the only related Gr 3 AE. There were 4 unrelated Gr 3 AEs (gastroenteritis, GI-hemorrhage, inguinal hernia, and syncope). There were no Gr 4-5 AE. ConclusionsEO has a favorable safety profile and is preliminary associated with an ORR of 47%, exceeding the pre-specified boundary for promising activity. The speed and level of expansion of both EO mimic and B cell target peptide specific CD8 memory T cells are associated with objective response. Results will be updated.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Tomaso BeringheliClément JavauxSandrine RouxEvelyne BraunPierre ChauvelotSylvain GoutelleThomas BriotJudith CottinCéline DupieuxJohanna BoulantAnne ConradFlorence AderTristan FerryFlorent ValourTristan FerryTristan FerryFlorent ValourClaire Triffault-FilitAgathe BeckerAnne ConradEvelyne BraunFlorence AderIsabelle EberlJoanna-Isabelle Kurban Bessa LippmanLorena Van-Den-BogaartMarie SimonOlivier BahuaudPierre ChauvelotSandrine RouxSarah SouegesSophie LandreThomas PerpointClément JavauxMarie WanCécile BataillerSébastien LustigElvire ServienGerald DelfosseGuillaume MesnardJean BaltzerJulien ErardNicolas CanceSébastien MartresFranck TrouilletStanislas GunstAlexandre CouraudonAnthony VisteFabien EwaldJean-Luc BesseMatthieu CotteMichel FessyPhilippe ChaudierThomas CuinetVianney DerreveauxAntoine BertaniAntoine ColasFrédéric RongierasJean-Baptiste MassonLéonard VézoleMaxime RarchaertVincent PibarotAram GazarianArnaud WalchChristophe GaillardGaetan VanpoulleLouis DucharneLyliane LyNael Ben-HadidSelma LahlaliThibault DruelVictor RutkaAlain-Ali MojallalAbdulrahman HashimGuillaume HenryHélène PersonMathilde LhermAudrey Chevreau-CilibertiCaroline MacabéoFrédéric AubrunKaissar RouhanaMikhail DziadzkoCéline DupieuxTiphaine Roussel-GaillardLaetitia BeraudMatthieu Curtil-Dit-GalinAni HorikianAnne-Lise MaucotelCamille KolendaJean-Philippe RasigadeAlexis TrecourtDavid GicquelGrégoire VervustIsabelle MorelecJean-Baptiste PialatJoris LavigneNicolas StacoffeAgnes HenryNoémie VieuxRomain GarreauThomas BriotSylvain GoutelleJohanna Boulant
• Organismes : Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Lyon Bone and Joint Infection Study Group Hospices Civils de Lyon Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques Hospices Civils de Lyon Evaluation et modélisation des effets thérapeutiques [LBBE] Université Claude Bernard Lyon 1 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique Hospices Civils de Lyon Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Centre International de Recherche en Infectiologie Pathogenèse des légionelles- Legionella pathogenesis [CIRI] Hospices Civils de Lyon Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Centre International de Recherche en Infectiologie Pathogenèse des légionelles- Legionella pathogenesis [CIRI] Lyon Bone and Joint Infection Study Group Centre International de Recherche en Infectiologie Hospices Civils de Lyon Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Background and objectives Due to its potentially better long-term haematologic tolerance compared to linezolid, tedizolid represents an attractive option for prolonged antibiotic therapy in complicated/chronic Gram-positive infections. However, there is little information regarding the risk of peripheral neurological toxicity, representing another obstacle to the extended use of oxazolidinones. Reporting neurologic adverse events occurring during tedizolid therapy for chronic implant-associated infections. Patients and methods Patients experiencing tedizolid-associated neurologic adverse events were retrospectively described in a case series. Results Five patients (four males; age range, 65–75 years) receiving tedizolid (200 mg q24h) as long-term suppressive therapy for chronic implant-associated infection presented with peripheral neuropathy. In four cases, tedizolid was used after discontinuation of linezolid for toxicity, including one case of neuropathy. Three had at least one additional risk factor for neuropathy (including two diabetes, one of them with diabetes-related nephropathy). Neuropathic symptoms [paraesthesia (n = 2), worsening of pre-existing neuropathy (n = 2), dysesthesias (n = 1)] appeared after a median of 12.4 (IQR, 8.2–13.3) months of tedizolid treatment. Electromyoneurography (EMNG) confirmed axonal sensory polyneuropathy in all but one patient for which EMNG was still within normal ranges, but compatible with incipient neurotoxicity. Tedizolid was stopped in all patients, three patients required specific treatment for neuropathic pain. At last follow-up [2.4 (IQR, 1–2.5) years from tedizolid discontinuation], clinical recovery from neuropathy was noted in three patients. The two patients with persistent neuropathy symptoms were diabetic; one showed EMNG improvement. Conclusions Prolonged used of tedizolid may be associated with peripheral neurologic toxicity, which should be monitored in at-risk patients.

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