Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 05/05/2026
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanJochen SchieckRobert SchöfbeckMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadArchana SharmaLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekHenriette Aarup PetersenSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereFrancisco Gameiro CasalinhoAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselDiego Matos FigueiredoThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesLuigi CalligarisFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangHeng YangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinClaudio QuarantaXiaohu SunDayong WangJin WangMingtao ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerZhipeng CuiBolin LiHui WangKai YiJingqing ZhangYuji LiYilin ZhouZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouSotiroulla KonstantinouChristos LeonidouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerEdy AyalaEdgar Carrera JarrinBasma El-MahdyShaaban KhalilAhmed HusseinHemida MohammedMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalNorman SeebaLaurits TaniErik BrückenAnna MilievaKenneth OsterbergMikko VoutilainenFrancisco Ignacio Garcia FuentesPatin InkaewKimmo Tuomas 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SokmenLourdes Urda GómezAlexandre ZabiAmina ZghicheJean-laurent AgramJeremy AndreaDaniel BlochJean-Marie BromEric Christian ChabertCaroline CollardGael CoulonSaskia FalkeUlrich GoerlachRaphael HaeberleAnne-Catherine Le BihanMeena MeenaOceane PoncetGourab SahaPaul VaucelleAdriano Di FlorioBreno OrzariDavid AmramStephanie BeauceronBenjamin BlanconGaelle BoudoulNicolas ChanonDidier ContardoPierre DepasseHoumani El MamouniJean FaySusan GasconMaxime GouzevitchChristopher GreenbergGérald GrenierBernard IlleElise Jourd'HuyMorgan LethuillierBenjamin MassoteauLaurent MirabitoArnab PurohitMuriel Vander DoncktJie XiaoGeorge AdamovIrakli LomidzeZviad TsamalaidzeValeria BottaSandra Consuegra RodríguezLutz FeldKatja KleinMartin LipinskiPhilipp NattlandVanessa OppenländerAlexander PaulsDanyer Pérez AdánNicolas RöwertCaio DaumannSvenja DiekmannNiclas EichDmitry EliseevFrederic EngelkeJohannes ErdmannMartin ErdmannBenjamin FischerThomas HebbekerKerstin HoepfnerFrancesco IvoneAlexander JungNitish 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StadieGeorg SteinbrückRobert WardBogdan WiederspanMoritz WolfChitrakshee YedeSebastian BrommerAlessandro BrusamolinoErik ButzYi-Mu ChenThorsten ChwalekAlexander DierlammGizem Gul DincerDmitry DruzhkinUmut ElicabukNils FaltermannManuel GiffelsArtur GottmannFrank HartmannMaximilian HorzelaFabian HummerUlrich HusemannJan KieselerMarkus KluteJoscha KnolleRufa Kunnilan Muhammed RafeekOlha LavorykJay Mathew LawhornAdelina LintuluotoStefan MaierArtur MonschMichele MormileThomas MüllerEmanuel PfefferMatteo PresillaGunter QuastKlaus RabbertzBrendan RegneryRalf SchmiederNikita ShadskiyIvan ShvetsovHans-Jürgen SimonisLars SowaLea StockmeierKomal TauqeerMaria TomsBogdan TopkoNicolò TrevisaniCedric VerstegeTim VoigtländerRalf Florian von CubeJost von den DrieschMichael WassmerChristian WinterRoger WolfWolfram Dietrich ZeunerXunwu ZuoGeorgios AnagnostouGeorgios DaskalakisAristotelis KyriakisGeorgios MelachroinosZacharias PainesisIoannis ParaskevasNiki SaoulidouKonstantinos TheofilatosEirini TziaferiEftychia TzovaraKonstantinos VellidisIlias ZisopoulosTheodoros ChatzistavrouGeorgia KarapostoliKonstantinos KousourisEirini SiamarkouGeorgios TsipolitisIoannis BestintzanosIoannis EvangelouCostas FoudasPanagiotis KatsoulisPanagiotis KokkasPolidamas Georgios Kosmoglou KioseoglouNikolaos ManthosIoannis PapadopoulosJohn StrologasCsaba HajduDezso HorvathKrisztina MártonAttila József RádlFerenc SiklerViktor VeszpremiMate CsanadKrisztián FarkasAnna FehérkutiMahmod Moussa Abdelkhalek GadallahÁrmin KadlecsikMoisés León CoelloGabriella PasztorGabor Istvan VeresBalazs UjvariGyula ZiliziGyorgy BenczeSandor CzellarJozsef MolnarZoltan SzillasiTamas Ferenc CsorgoFrigyes NemesTamas NovakIstvan SzanyiSeema BahinipatiSamarendra NayakRishabh RaturiSunil BansalSuman Bala BeriVipin BhatnagarSushil ChauhanNitish DhingraAnureet KaurHarjot KaurManjit KaurSunil KumarTanvi SheokandJasbir SinghAayushi SinglaAshutosh BhardwajArjun ChhetriBrajesh C ChoudharyAshok KumarArun KumarMohammad NaimuddinSaumya 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OrimotoLouise SkinnariCort Stewart ThoresonEmily TsaiDarien WoodSusan DittmerKristian Allan HahnMichael McginnisYulun MiaoDavid Gabriel MonkMichael Henry SchmittAngela TaliercioMayda VelascoJinglu WangGarvita AgarwalReyer BandRachael BucciSergi CastellsAbhishek DasAbhisek DattaAmanda EhnisReza GoldouzianMichael HildrethKenyi Hurtado AnampaTodor IvanovColin JessopAnton KarneyeuKevin LannonJohn LawrenceNikitas LoukasDylan LuttonJoseph MarianoNancy MarinelliThomas MccauleyChristopher McgradyConnor MooreYuri MusienkoHannah NelsonMarc OshersonAndrea PiccinelliRandy RuchtiAustin TownsendYuyi WanMitchell WayneHenry YockeyMichael CarriganRyan de los SantosLloyd Stanley DurkinChristopher HillMatthew JoyceDerek Albert WenzlBrian L WinerBrent YatesHichem BouchamaouiGage DezoortPeter ElmerAndre FrankenthalMassimiliano GalliBennett GreenbergNicholas HaubrichKiley KennedyGillian KoppYihui LaiDavid LangeAndrew LoeligerDaniel MarlowIsabel OjalvoJames OlsenFarrah SimpsonDavid SticklandChristopher 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ReichertPrafulla SahaSevil SalurSteve SchnetzerSunil SomalwarRobert StoneSteffie Ann ThayilScott ThomasJay VoraDaniel AllyAndrés G DelannoySara FiorendiJesse HarrisTova HolmesAnkush Reddy KanugantiNimmitha KarunarathnaJohn LawlessLawrence LeeEmery NibigiraBrandi SkipworthStefan SpanierDevin AebiMuhammad AhmadTowsifa AkhterKonstantin AndrosovAashwin BasnetArtem BolshovOthmane BouhaliAntimo CagnottaValeria d'AmanteRicardo EusebiPatrick FlanaganJason GilmoreYumeng GuoTeruki KamonSifu LuoRyan MuellerAlexei SafonovNural AkchurinJordan DamgovYongbin FengNiramay GogateWeijie JinYelbir KazhykarimKamal LamichhaneSung Won LeeChristopher MadridAaron MankelTimo PeltolaIgor VolobouevEric AppeltYi ChenSenta GreeneAlfredo GurrolaWillard JohnsRaghav Kunnawalkam ElayavalliAndrew MeloDenis RathjensFrancesco RomeoPaul SheldonShengquan TuoJulia VelkovskaJussi ViinikainenJingyu ZhangBryan CardwellHeewon ChungBradley CoxJohn HakalaGabriela Hamilton Ilha MachadoRobert HiroskyMaria JoseAlexander LedovskoyCristina MantillaChristopher NeuClara Ramón ÁlvarezZhenyu WuSaptaparna BhattacharyaPaul Edmund KarchinAnagha AravindSunanda BanerjeeKevin BlackTulika BoseElise ChavezSridhara DasuPieter EveraertsCamilla GalloniHe HeMatthew HerndonAlain HerveCharis Kleio KorakaShivani LomteRichard LovelessAbhishikth MallampalliAbdollah MohammadiSusmita MondalTrevor NelsonGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinYuri AndreevTagir AushevDzmitry BudkouskiRuslan ChistovMikhail DanilovTatyana DimovaAlexander ErshovSergei GninenkoIlya GorbunovAndrey GribushinAlexey KamenevVladimir KarjavineMikhail KirsanovVyacheslav KlyukhinOlga KodolovaVladimir KorenkovIurii KorsakovAleksei KozyrevNikolai KrasnikovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginSergey PetrushankoOlesia RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenKirill SlizhevskiyVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinAnatoli ZarubinIlia ZhizhinLev DudkoVictor KimVictor MurzinVadim OreshkinDmitry SosnovEdouard BoosViacheslav BunichevMikhail DubininViktor SavrinAlexander Snigirev
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon

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Résumé : A search for dark matter produced in association with a dark Higgs boson decaying into a bottom quark-antiquark pair has been performed using proton-proton collision data at a center-of-mass energy of 13 TeV. The search uses data collected with the CMS detector at the CERN LHC during the 2016$-$2018 data-taking period, corresponding to an integrated luminosity of 138 fb$^{-1}$. The results are interpreted in terms of a theoretical model of dark matter production that, together with a spin-1 gauge boson mediator, predicts the existence of a Higgs-boson-like particle in the dark sector (i.e., a dark Higgs boson). This search focuses on an experimental signature with large missing transverse momentum from dark matter production and a resonant structure in the invariant mass of the bottom quark-antiquark pair from the dark Higgs boson decay. Upper limits at 95% confidence level on the signal strength for dark Higgs boson mass hypotheses below 160 GeV are set. Values of the mediator mass up to 4.5 (2.5) TeV are excluded at 95% confidence level for a dark Higgs boson mass of 50 (150) GeV. This represents the most stringent limits set to date for the dark Higgs boson masses considered in this study.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2026
• Auteurs : Caroline RobertEmilie GérardEmilie LanoyGaelle QuéreuxPhilippe BernardManuelle ViguierFlorent GrangeNicolas MeyerMonica DinulescuDelphine LegoupilEve Marie NeidhardtPhilippe SaiagSabiha TrabelsiPhilippe CélérierCharlee NardinEve MaubecAnne-Benedicte Duval- ModesteEwa HainautSophie DarrasHerve MaillardSarah GueganJean-Philippe ArnaultPierre-Emmanuel StoebnerYannick Le CorreLucie PeuvrelBertille BonniaudHugo HerrscherFlorence Granel-BrocardAnne-Lise VataireAurore TabellionCéleste LebbéLaurent Mortier
• Organismes : Université Paris-Saclay Département de médecine oncologique [Gustave Roussy] Hôpital Saint-André CIC - HEGP Immunology and New Concepts in ImmunoTherapy Centre Hospitalier Universitaire Dupuytren 1 et 2 Hôpital Robert Debré Centre hospitalier de Valence Clinique Médipôle Garonne CRLCC Eugène Marquis Hôpital Morvan [Brest] Centre Léon Bérard [Lyon] Hôpital Ambroise Paré [AP-HP] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Hôpital Avicenne [AP-HP] CHU Rouen Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Boulogne-sur-mer Centre Hospitalier Le Mans (CH Le Mans) Paris Santé Cochin CHU Amiens-Picardie Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Universitaire d'Angers Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Groupe Hospitalier Saint-Vincent Centre Hospitalier Régional Universitaire de Nancy Sanofi Winthrop Industry [Paris] Sanofi Winthrop Industry [Paris] Immunologie humaine, physiopathologie & immunothérapie Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé : Background: Cemiplimab an anti-programmed cell death receptor-1 antibody, was approved by the FDA and EMA for patients with locally advanced cutaneous squamous cell carcinoma (laCSCC) ineligible for curative surgery/radiotherapy or with metastatic (m) CSCC. TOSCA study evaluated the real-world effectiveness and safety of cemiplimab compared to historical systemic therapies (HSTs). Methods: TOSCA (NCT05302297) was a large French retrospective, multicenter study comparing patient with la/mCSCC treated with cemiplimab via the early access program (EAP, 2018-2019) or HST (2013-2018). The primary endpoint was overall survival (OS); secondary endpoints were progression-free survival (PFS), duration of response (DoR), overall response rate (ORR), and safety. Effectiveness analysis using inverse probability weighting included a trial-like cohort of only immunocompetent patients meeting the EAP criteria to emulate a randomized clinical trial; safety analysis included all real-life patients. Findings: The study included 280 real-life patients (cemiplimab: n = 147; HST: n = 133). The primary effectiveness analysis included a trial-like cohort (cemiplimab: n = 129; HST: n = 70; median age: 81 and 78 years, respectively). Median follow-up was 20 and 10 months in the cemiplimab and HST arms, respectively; median OS was 21.2 and 9.8 months, respectively (HR 95% CI: 0.57 [0.45-0.73]; P < 0.0001); median PFS was 13.7 and 5.3 months, respectively (HR [95% CI]: 0.57 [0.43-0.76]; P = 0.0001). Adverse drug reactions occurred in 27% of cemiplimab patients and 33% of HST patients. Interpretation: TOSCA demonstrated better survival and response outcomes for cemiplimab versus HST in la/mCSCC; emphasizing, the importance of this retrospective studie in the absence of standard comparative trials.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2026
• Auteurs : Antoine GavoilleAnne KerbratGilles EdanEmmanuelle Le PageFabien RollotRomain CaseyGuillaume MatheyBruno StankoffJonathan CironJérôme de SèzeAurélie RuetPierre M. LabaugeArnaud KwiatkowskiHélène ZéphirCaroline PapeixGilles-Louis DeferChristine Lebrun-FrenayThibault MoreauEric BergerPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabThomas DavidLaurent MagyJean-Philippe CamdessanchéSolène MoulinInès DoghriMariana SarovAmélie dos SantosCorinne PottierÉric ManchonJennifer AboabMaya TchikviladzeCamille DahanPierre DurozardClarisse Scherer-GagouAlexandre LeclancherDavid-Axel LaplaudSandra VukusicLaure MichelFrançois CottonPascal DouekF. GuilleminAlexandre PachotJavier OlaizClaire Rigaud-BullyRomain MarignierDamien BiottiJean-Christophe OualletNicolas CollonguesOlivier OutteryckXavier MoissetNathalie DeracheMikael CohenAgnès FromontSandrine WiertlewskyMatthieu BereauXavier MoissetBertrand AudoinClaire GiannesiniCaroline BensaGiovanni CastelnovoOmbeline FagniezBenjamin HebantMathieu VaillantSéverine JeaninAlain CréangeJean-Michel VallatPhilippe ConversStéphane BeltranCéline LabeyrieCarole HenryMarie CamuzeauxMaryline DelattreLaura TrottaCatherine GirodAmandine Ostermann-ZieglerDamien Le PortNoellie FreitasCarole BertheKaty-Kim LatasteKarima ZehrouniFrédéric PinnaJulie PetitSadou Safa DialloKarine DroulonCéline CallierAlexia ProtinMelinda MoyonChrystelle CappeSadou Safa DialloEmilie DumontHanane AgherbiMarie BlanchereMarie-Pierre RanjevaAmandine da VeigaMaty Diop KaneChristine VimontMarjory CayolSafiyatou BaldeDaisy RousseauKarine FerraudGéraldine MeunierElise VarnierEdwige LescieuxHalima BourenaneStéphanie CossecEmilie RaboisLynda BenammarAnaïs Beulaygue
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique de Nancy Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hôpital Saint Vincent de Paul [Lille] Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Hôpital Pasteur [Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Service de Neurologie [CHRU Besançon] Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Hôpital de la Timone [CHU - APHM] Aix Marseille Université Neurologie [CHU Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Psychiatrie et Neurologie personnalisées [CHU Henri-Mondor] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Service de Neurologie [CHU Limoges] Service de Neurologie [CHU de Saint-Étienne] Service de neurologie [Reims] Centre Hospitalier Régional Universitaire de Tours Service de neurologie [Le Kremlin Bicêtre] Service de neurologie [CHU de Poitiers] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier de Gonesse Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts Hôpital Foch [Suresnes] Centre hospitalier de Pau Centre hospitalier d'Ajaccio Service de neurologie [Angers] Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CIC Plurithématique de Nantes Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de Neurologie [Rennes] = Neurology [Rennes] Centre d'Investigation Clinique [Rennes]
• Publié dans Neurology le 01/11/2020

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Résumé : Background and objectives: The therapeutic strategy for late-onset multiple sclerosis (LOMS) with a relapsing-remitting onset remains unclear, potentially leading to underexposure to disease-modifying therapies (DMTs) compared with adult-onset multiple sclerosis (AOMS). We investigated the differences in DMT use between LOMS and AOMS within the French MS registry at comparable levels of disease severity. Methods: This retrospective cohort study used data extracted in December 2024 from the French MS registry on patients with relapsing-remitting onset MS between 1997 and 2023. The primary outcome was the annual probability of receiving a DMT according to age at MS onset, adjusted for disease severity. Secondary outcomes included the annual probability of receiving a highly effective DMT (HEDMT), each DMT separately, having ≥1 EDSS measurement, having ≥1 brain MRI, and DMT initiations and discontinuations. We used a longitudinal logistic model with generalized estimating equations and an inverse-probability-of-censoring weighting. Results: A total of 36,148 were included patients; 26,540 (73.4%) were female, mean age was 33.5 years (SD, 9.7), and 2,308 (6.4%) were aged ≥50 at disease onset. Median follow-up was 10.8 years (interquartile range, 5.6-17.0). Patients with LOMS had a lower annual probability of receiving a DMT compared with patients with AOMS (73.7% vs 83.1%; odds ratio [OR], 0.57 [95% CI 0.52-0.62]). The difference was greater for HEDMT (24.6% vs 44.4%; OR, 0.41 [95% CI 0.36-0.46]). Patients with LOMS were more likely to receive teriflunomide and less likely to receive fumarates, S1PR modulators, natalizumab, or anti-CD20. Clinical and radiologic follow-up did not differ significantly between patients with LOMS and AOMS. The rate of DMT initiation was lower in patients with LOMS (0.13 vs 0.17 initiation per patient-year). Although the proportions of DMT discontinuation were similar (59.7% vs 60.4%, excluding pregnancy-related discontinuations), these discontinuations were more often attributed to a complete discontinuation strategy (27.9% vs 22.3%) and less often to an escalation strategy (9.2% vs 13.8%) in patients with LOMS. Discussion: At comparable levels of disease severity, patients with LOMS were less likely to be treated with DMTs, particularly HEDMT, than patients with AOMS. This gap was driven both by fewer DMT initiations and more frequent complete discontinuations.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2026
• Auteurs : Tim RietbergSusana BarbosaPieter MeysmanBruno AouizerateFrank BellivierFabrice BernaDelphine CapdevielleIsabelle Chereau-BoudetPhilippe CourtetClément DondéCaroline DubertretB EtainWissam El-HageMona GerentesJérôme HoltzmannEric FakraEmmanuel HaffenNoomane BouazizAntoine LefrerePierre-Michel LlorcaJasmina MalletDavid MisdrahiÉmilie OliéAgnès PelletierGiulia PivaBaptiste PignonMircea PolosanRomain ReyPaul RouxLudovic SamalinFranck SchürhoffRaymund SchwanFlorian StéphanDavid SzekelyMathieu UrbachGuillaume VaivaEtienne VeryAntoine YrondiMarion LeboyerLivia de PickerOphélia Godin
• Organismes : Universiteit Antwerpen = University of Antwerp Equipe Sociale Santé Mentale et Addictions [iPLesp] Sorbonne Université Universiteit Antwerpen = University of Antwerp Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpitaux Universitaires de Strasbourg Fédération de Médecine Translationnelle de Strasbourg Neuroscience et Psychiatrie Translationnelle de Strasbourg Fondation FondaMental [Créteil] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Université Clermont Auvergne Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Alpes Isère [Grenoble, France] Fondation FondaMental [Créteil] Pôle Psychiatrie et Neurologie [Grenoble] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Imaging, Brain & Neuropsychiatry Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Henri Mondor Fondation FondaMental [Créteil] Pôle Psychiatrie et Neurologie [Grenoble] Fondation FondaMental [Créteil] Pôle Psychiatrie [CHU Saint-Etienne] Centre hospitalier Charles Perrens [Bordeaux] Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive Université Marie et Louis Pasteur Fondation FondaMental [Créteil] Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Université Sorbonne Paris Nord Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Assistance Publique - Hôpitaux de Marseille Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Laboratoire Interdisciplinaire pour l'Innovation et la Recherche en Santé d’Orléans Centre Hospitalier Universitaire d'Orléans Fondation FondaMental [Créteil] Etablissement public de santé mentale du Loiret Georges Daumézon Université de Bordeaux Fondation FondaMental [Créteil] Institut de Neurosciences cognitives et intégratives d'Aquitaine Centre hospitalier Charles Perrens [Bordeaux] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Henri Mondor Fondation FondaMental [Créteil] Centre Hospitalier le Vinatier [Bron] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Université Claude Bernard Lyon 1 Fondation FondaMental [Créteil] Hôpital Henri Mondor IMRB - "Neuropsychiatrie translationnelle" [Créteil] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Alpes Isère [Grenoble, France] Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Centre Hospitalier de Versailles André Mignot Fondation FondaMental [Créteil] Centre de recherche en épidémiologie et santé des populations Fondation FondaMental [Créteil] Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Fondation FondaMental [Créteil] Université Paris-Est Créteil Val-de-Marne - Paris 12 Hôpital Henri Mondor IMRB - "NeuroPsychologie Interventionnelle" [Créteil] Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Imagerie Adaptative Diagnostique et Interventionnelle Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Fondation FondaMental [Créteil] CHRU Brest - Psychiatrie Adulte Hôpital Princesse Grace [Monaco] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Fondation FondaMental [Créteil] Centre National de Ressources et de Résilience [Lille] Fondation FondaMental [Créteil] Service Psychiatrie, Psychothérapies et Art-thérapie [CHU Toulouse] Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs Toulouse NeuroImaging Center Service Psychiatrie et psychologie médicale [CHU Toulouse] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] Hôpital Henri Mondor Université Paris-Est Créteil Val-de-Marne - Faculté de médecine Universiteit Antwerpen = University of Antwerp Fondation FondaMental [Créteil] Hôpital Henri Mondor IMRB - "Neuropsychiatrie translationnelle" [Créteil] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine
• Publié dans Brain, Behavior, and Immunity le 29/10/2020

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Résumé : Background and objectives: Low-grade systemic inflammation contributes to the pathophysiology of severe mental illness (SMI) in a substantial subset of patients, who often experience greater disease burden and poorer treatment response. Elevated C-reactive protein (CRP), defined as CRP ≥ 3 mg/L, has been proposed to identify this group, but its non-specificity limits the biomarker's ability to guide targeted intervention. We aimed to determine the most consistent drivers of high CRP across bipolar disorder (BD), schizophrenia (SZ) and major depressive disorder (MDD), and to translate these into clinically actionable intervention targets using robust data-driven methods. Methods: We pooled and harmonised data from three large French national SMI cohorts (n = 7149: 4797 bipolar disorder, 1958 schizophrenia and 394 resistant major depression) and classified participants by CRP ≥ 3 mg/L, as well as an alternative cut-off of 5 mg/L. We applied penalised logistic regression (PLR), random forests (RF) and unsupervised clustering, using 28 biopsychosocial variables to identify robust drivers of high-CRP status. We then grouped these into actionable targets and assessed relative dominance. Results: In total, 30.16% of participants had CRP ≥ 3 mg/L. PLR identified female sex (OR [95% CI]: 1.60 [1.27, 1.93]), higher BMI (OR: 1.09 [1.07, 1.13]), current nicotine dependence (OR: 1.05 [1.02, 1.09]), lower HDL cholesterol (OR: 0.57 [0.44, 0.73]) and smoking (ex-smoker status OR: 0.84 [0.66, 0.98]) as consistent drivers. RF highlighted a similar set of key drivers, also including waist circumference, triglycerides and cardiovascular comorbidities. Clustering of the high-CRP group was almost entirely driven by smoking status and nicotine dependence. When grouped into actionable targets, the identified drivers accounted for 16% of variance in CRP status, with obesity emerging as most dominant contributor. This pattern was most pronounced in females; in males it was more diffuse, with a more prominent role for smoking. Conclusions: We propose a decision tree framework where CRP can serve as a first-line screening marker for inflammation in SMI, with subsequent steps focusing on the main contributing factors to guide targeted interventions. Priority should be given to targeting obesity and metabolic dysregulation. Among females, hyperuricemia represents the next most appropriate target, whereas in males, smoking warrants greater attention. This stepwise approach provides a route from a nonspecific biomarker to targeted treatment strategies and should be validated in prospective studies.

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Fichiers liés : 1-s2.0-S0889159126002126-main.pdf

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