Philippe JEAN-PIERRE

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/10/2025
• Auteurs : Pierre FerranPierre Chaffard-LuçonPierre VandierPhilippe JacobBernard PêcheurOlivier GohinLuc KleinJean-Christophe VidelinNathalie DurhinPhilippe GicquelJean-Michel MantinPhilippe PourquéIsabelle DelarbreJacques AbenBertrand MichelsPierre-Paul MarchiChristophe MaurietOlivier Marcotte
• Organismes : Service du commissariat des armées Institut Catholique de Paris (ICP) Service du commissariat des armées Centre Universitaire Rouennais d’Études Juridiques Ministère des armées – Ministère de la défense [France] (1946-....) Service du commissariat des armées Université Panthéon-Assas Centre d’Etudes et de Recherche en Droit Administratif, Constitutionnel, Financier et Fiscal Université Paris 1 Panthéon-Sorbonne Institut de Recherche juridique de la Sorbonne André Tunc Centre de Recherches Juridiques Service du commissariat des armées Direction de l'Administration Pénitentiaire Service du commissariat des armées Service du commissariat des armées Centre de Recherches Interdisciplinaires en Sciences humaines et Sociales de Montpellier Université de Montpellier Service du commissariat des armées Service du commissariat des armées Ministère des armées – Ministère de la défense [France] (1946-....) Service du commissariat des armées

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Résumé : Contemporain et théoricien des guerres napoléoniennes, le Suisse Antoine-Henri de Jomini soulignait en 1838 que la logistique forme une des parties les plus essentielles de l’art de la guerre, au même titre que la stratégie ou la tactique. Cette affirmation peut assurément être posée au sujet de l’administration militaire. Dans l’histoire récente, les armées françaises ont été et sont encore confrontées à différentes conflictualités. Elles doivent poursuivre leurs efforts face aux nombreux défis qui apparaissent dès l’étape de la compétition afin de « gagner la guerre avant la guerre ». Parmi ces défis se trouvent une préparation, un concept d’emploi, des équipements permettant aux forces armées de faire face à leurs engagements opérationnels, mais aussi un soutien adapté à ceux-ci. En effet, les forces engagées sur les théâtres d’opérations sont autant confrontées à leur adversaire qu’aux contraintes de la vie en campagne qui nécessitent une grande variété de moyens : ravitaillements, transport, matériels, habillement, vivres… L’administration militaire permet aux armées de se préparer à leurs engagements opérationnels et participe activement au déroulement de ceux-ci, ainsi que l’a relevé la citation à l’ordre de l’armée décernée le 16 septembre 2024 par le ministre des armées au Service du commissariat des armées pour son soutien à l’opération « Barkhane » en Afrique sahélo-saharienne. Aussi, loin d’être un sujet déconnecté du terrain, l’administration militaire occupe au contraire une place centrale dans la pensée stratégique des armées. Afin de nourrir sa réflexion et de questionner ses pratiques, le Service du commissariat des armées a organisé le 8 décembre 2023 un colloque intitulé « le soutien des forces armées : l’administration militaire et sa singularité face aux situations de crises et de conflits ». Cet ouvrage regroupe les interventions qui ont concouru à cet évènement, augmenté de quelques contributions supplémentaires.

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Fichiers liés : PDF Numerique_Actes colloques_Soutien Forces Armees__12-02-2026.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Jordi MiatelloAlba Palacios-CuestaPeter RadellAndré OberthuerStephen PlayforIrene Amores-HernándezSimon BarreaultRichard BiedermannMaria Teresa Charlo MolinaJuan Encarnación MartínezBenjamin KuehneSantiago MencíaMaria Dolores MéndezChristoph MenzelLuc MorinLidia OviedoJean-Eudes PiloquetMagnus FalkenhavPeter SackeyUwe TrieschmannPierre TissieresRamy CharbelClémence MaraisFlorent BaudinFleur Cour-AndlauerNicolas JoramJulien JegardMichael LevyJerome NaudinMaxence FernandesOmbeline RoignotJoelle BeaudetSandrine de SampaioYohan SorezePhilippe MeyerFrancois MoreauAna Maria Llorente de la FuenteOlga Ordóñez SáezHugo AhernRubén FerrerasCarmen Román-HernándezGuillermo Santos-SimarroRosa Maria Rodríguez SánchezElisa Mérida AlesElia Sánchez ValederrábanosManuel Fernández ElíasRaquel CiezaAlba CorchadoJosé Luis Unzueta-RochCristina Yun CastillaRaúl Montero YébolesLaura Díaz RuedaMónica Girona-AlarconSara Bobillo-PérezChristoph UlrichsMona StröhleinHans ProquittéRené HöhnChristoph ZürnMonika WolfAnand PatilPadmanabhan Ramnarayan
• Organismes : Agressions Pulmonaires et Circulatoires dans le Sepsis - UR Hospices Civils de Lyon
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Émilie PicardFatima Domenica Elisa de PalmaSophia LoiodiceVincent CarbonnierSeiki AchiedoNoor MimounDiluxe MutaleSophie DoublierSylvère DurandMélanie BourginFanny AprahamianPierre CordierLouise GutterKatia JedeonMarie-Christine NaudPhilippe NoirezJean-Marc RicortLotfi SlimaniGuido KroemerFrancine Behar-CohenMaria Chiara MaiuriSylvie Babajko
• Organismes : Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Santé orale Centre de Recherche des Cordeliers Métabolisme, cancer et immunité = Metabolism, Cancer & Immunity [CRC] Métabolisme, cancer et immunité = Metabolism, Cancer & Immunity [CRC] Métabolisme, cancer et immunité = Metabolism, Cancer & Immunity [CRC] École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique Centre de Recherche des Cordeliers Santé orale Centre de Recherche des Cordeliers Performance, Santé, Métrologie, Société - EA 7507 Santé orale Ecole Normale Supérieure Paris-Saclay Santé orale Centre de Recherche des Cordeliers Institut Gustave Roussy Cancer Research and Personalized Medicine - CARPEM [Paris] Centre de Recherche des Cordeliers Métabolisme, Cancer et Immunité Santé orale
• Publié dans Environment International le 30/10/2020

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Résumé : Exposure to environmental pollutants may contribute to various health disorders, often manifesting after a prolonged period of latency. The identification of early markers is, therefore, of paramount importance.

To achieve this objective, realistic models of environmental exposure were set up. Whereas most studies consider one substance or mixture with one target organ, here, in addition to the liver, two easily accessible sensitive organs, the eyes and teeth, were analyzed as good potential candidates to be original markers of environmental exposures. C57BL/6J mice were exposed to either sodium fluoride or a mixture of 15 endocrine-disrupting substances, or both, in their drinking water from the time of conception until 1 or 10 months after birth. The doses of these substances were chosen to be close to the tolerable daily intake.

All mice in test groups presented lower weight gain than controls with the most significant differences observed in females 30 days after birth. Alterations in the eye retina were detected as early as 1 month of age and considerably worsened by 10 months. Dental defects were observed in all test groups at the last time point. At that age, metabolic disruptions were identified through molecular metabolomic and RNAseq analyses, while histological analyses showed no significant defects in liver.

This study shows that chronic exposure to widespread toxicants resulted in hepatic metabolic disorders. However, the most evident histological and clinical signs were observed in eyes and teeth. These easily accessible stigmata may be used as early markers of low-dose exposure to environmental toxicants.

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Fichiers liés : Picard, de Palma et al main_post print.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Antoine GavoilleFabien RollotRomain CaseyGuillaume MatheyEmmanuelle Le PageJonathan CironJérôme de SèzeAurélie RuetÉlisabeth MaillartPierre LabaugeHélène ZéphirArnaud KwiatkowskiCaroline PapeixGilles DeferChristine Lebrun-FrenayThibault MoreauDavid-Axel LaplaudEric BergerAnne-Laure DubessyPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al-KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagySolène MoulinJean-Philippe CamdessanchéInès DoghriMariana Sarov-RiviereKarolina HankiewiczCorinne PottierAmélie dos SantosChantal NifleFabien SubtilSandra VukusicFrançois CottonPascal DouekF. GuilleminAlexandre PachotJavier OlaizClaire Rigaud-BullyRomain MarignierGuillaume MatheyAnne KerbratDamien BiottiJean-Christophe OualletNicolas CollonguesOlivier OutteryckXavier MoissetNathalie DeracheMikael CohenAgnès FromontSandrine WiertlewskyMatthieu BereauBertrand AudoinClaire GiannesiniCaroline BensaGiovanni CastelnovoOmbeline FagniezBenjamin HebantMathieu VaillantSéverine JeaninAlain CréangeJean-Michel VallatPhilippe ConversStéphane BeltranCéline LabeyrieCarole HenryMarie CamuzeauxMaryline DelattreLaura TrottaCatherine GirodAmandine Ostermann-ZieglerDamien Le PortNoellie FreitasCarole BertheKaty-Kim LatasteKarima ZehrouniFrédéric PinnaJulie PetitSadou Safa DialloKarine DroulonCéline CallierAlexia ProtinMelinda MoyonChrystelle CappeEmilie DumontHanane AgherbiMarie BlanchereMarie-Pierre RanjevaAmandine da VeigaMaty Diop KaneChristine VimontMarjory CayolSafiyatou BaldeDaisy RousseauKarine FerraudGéraldine MeunierElise VarnierEdwige LescieuxHalima BourenaneStéphanie CossecÉmilie RaboisLynda BenammarAnaïs Beulaygue
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique - Epidémiologie clinique [Nancy] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de Neurologie [Strasbourg] Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Saint Vincent de Paul [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université Paris Cité Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Service de Neurologie [CHU Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Service de Neurologie [CHRU Besançon] CHU Pitié-Salpêtrière [AP-HP] Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Hôpital Henri Mondor Service de Neurologie [CHU Limoges] Service de neurologie [Reims] Service de Neurologie [CHU de Saint-Étienne] Centre Hospitalier Régional Universitaire de Tours Service de neurologie [Le Kremlin Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] Hôpital NOVO Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre Hospitalier de Versailles André Mignot Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS
• Publié dans JAMA neurology le 24/10/2020

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Résumé : Importance: In women with multiple sclerosis (MS), disease-modifying therapy (DMT) management during pregnancy might impact relapse risk. Objective: To estimate the effect of DMT management during pregnancy on MS relapse rate and compare different therapeutic strategies. Design, setting, and participants: This was a multicenter retrospective cohort study using data from January 1990 to December 2023. Data were extracted in December 2023 from the French MS registry. Among 52 955 women in the registry, we included pregnancies identified through childbirths in patients with relapsing-onset MS who were monitored for at least 18 months before delivery and 9 months after. Pregnancies occurring less than 18 months apart or with missing month of birth were excluded. Exposures: Mediation analysis was used to estimate the total, direct, and indirect (mediated by DMT management) effects of pregnancy. Different therapeutic strategies were compared: DMT interruption, switching to or maintaining interferon β or glatiramer acetate, switching to or maintaining natalizumab until the third trimester, and switching to or maintaining intravenous anti-CD20 and interrupting it 3 months before conception. Main outcomes and measures: The primary outcome was the annualized relapse rate (ARR) during the preconception, gestation, and postpartum periods. Within a causal inference framework, counterfactual ARRs were estimated using longitudinal g-computation, combining a random forest algorithm for predicting DMTs, and a mixed-effects Poisson model for relapses. Results: We included 6341 pregnancies occurring in 4998 women (mean [SD] age at conception, 31.5 [4.5] years). DMT management during pregnancy significantly increased ARR during gestation (causal rate ratio [cRR], 1.13; 95% CI, 1.06-1.22) and postpartum (cRR, 1.08; 95% CI, 1.01-1.16) periods. This led to a deleterious total effect of pregnancy on ARR, particularly in women receiving natalizumab before pregnancy with prolonged interruption (ie, interruption before the second trimester or resumption more than 3 months after delivery; cRR, 2.18; 95% CI, 1.76-2.69), and in women receiving fingolimod (cRR, 2.15; 95% CI, 1.60-2.93). Compared to DMT interruption, anti-CD20 strategy was the most effective (cRR, 0.38; 95% CI, 0.25-0.52), followed by the natalizumab strategy with short interruption (cRR, 0.80; 95% CI, 0.71-0.90), whereas interferon β (cRR, 0.93; 95% CI, 0.86-0.99) and glatiramer acetate strategies (cRR, 0.91; 95% CI, 0.84-0.99) were less effective. Conclusion: In this study, DMT management during pregnancy significantly increased relapse risk, particularly in patients receiving natalizumab with prolonged interruption or fingolimod. The strategy based on the use of anti-CD20 before pregnancy was the most effective to mitigate this risk.

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Fichiers liés : Gavoille - 2025 - Therapeutic Management during Pregnancy on Relapse Risk in.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/09/2025
• Auteurs : Francis SchneiderSophie HelleJean-Marc StrubFrançois-Xavier von HunolsteinPierre SchaafPhilippe LavalleFrancesco ScavelloMarie-Hélène Metz-Boutigue
• Organismes : Biomatériaux et Bioingénierie Fédération de Médecine Translationnelle de Strasbourg Biomatériaux et Bioingénierie Laboratoire de Spectrométrie de Masse BioOrganique [Strasbourg] Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Istituto Clinico Humanitas [Milan] Biomatériaux et Bioingénierie
• Publié dans Antibiotics le 24/10/2020

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Résumé : Background: Whether therapeutic albumin (ThHSA) can serve as a defense tool in Candida species (spp.) infections is still a matter of debate, although many physicians are in the habit of infusing ThHSA to restore the physiological concentration of endogenous human serum albumin (HSA). Given the need for innovative anti-Candida strategies, we assessed in vitro the role of ThHSA alone or in combination with voriconazole (VCZ) in combating Candida spp. growth and the role of bovine serum albumin (BSA)-used as a substitute for HSA-with two endogenous bovine antimicrobial peptides in combating C. albicans and other microbes. Results: The combination of ThHSA with VCZ enhanced the antifungal effect on C. albicans, sensitive C. tropicalis, sensitive C. glabrata, and C. lusitaniae. However, for resistant C. tropicalis, the combination of ThHSA with VCZ promoted yeast growth, and VCZ tended to suppress the antimicrobial effect of ThHSA on resistant C. glabrata. As to the possible transposition of ThHSA-type properties to BSA (as regards the growth inhibition of other pathogens), we tested combinations of BSA with two physiological chromogranin A-derived antimicrobial peptides (catestatin and cateslytin). BSA enhanced significantly the activity of catestatin (but not cateslytin) in combating C. albicans, A. fumigatus, and M. luteus, but was inactive against S. aureus and E. coli. Conclusions: Our experiments support the fact that albumins display intrinsic antimicrobial properties, with an unpredictable growth inhibitory effect on various microbes. ThHSA can thus be an adjunctive tool for more efficient care of some, though not all, infections. The interaction of BSA with catestatin and cateslytin is related to their structure, with BSA significantly enhancing the effect of catestatin but not that of cateslytin.

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Fichiers liés : antibiotics-14-00974-v4.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/09/2025
• Auteurs : Benjamin TorresLuc BlarelPhilippe GoloubGaël DuboisMaria Fernanda Sanchez-BarreroIoana Elisabeta PopoviciFabrice MaupinElena LindAlexander SmirnovIlya SlutskerJulien ChimotRamiro GonzálezMichaël SicardJean Marc MetzgerPierre Tulet
• Organismes : Laboratoire d’Optique Atmosphérique - UMR 8518 Laboratoire d’Optique Atmosphérique - UMR 8518 Laboratoire d’Optique Atmosphérique - UMR 8518 Laboratoire d’Optique Atmosphérique - UMR 8518 Laboratoire d’Optique Atmosphérique - UMR 8518 Laboratoire d’Optique Atmosphérique - UMR 8518 Société Cimel Électronique NASA Goddard Space Flight Center NASA Goddard Space Flight Center Science Systems and Applications, Inc. [Lanham] NASA Goddard Space Flight Center Science Systems and Applications, Inc. [Lanham] NOVELTIS [Sté] Laboratoire de l'Atmosphère et des Cyclones Observatoire de REcherche Méditerranéen de l'Environnement Laboratoire d'aérologie
• Publié dans Atmospheric Measurement Techniques le 24/10/2020

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Résumé : The Earth's oceans play a critical role in regulating the global climate and atmospheric processes, with marine aerosols significantly influencing weather patterns, air quality, and climate dynamics. Despite extensive land-based aerosol monitoring through networks like AERONET (AErosol RObotic NETwork), marine aerosol characterization remains a critical gap, due in part to the logistical challenges of conducting measurements in remote oceanic environments. To address this, robust, automated, and precise monitoring systems adapted for research vessels are essential. This study reports on the first 3 years (July 2021–June 2024) of continuous aerosol optical depth (AOD) measurements collected aboard the research vessel Marion Dufresne using a ship-adapted CIMEL CE318-T automatic photometer in the frame of the MAP-IO (Marion Dufresne Atmospheric Program – Indian Ocean) program. The dataset comprises over 25 000 quality-assured AOD measurements, primarily from the southwest Indian Ocean region, revealing mid-range AOD and Ångström exponent values consistent with previous studies. The reliability and precision of the system were validated through dual-instrument comparisons conducted during the Amaryllis-Amagas/Transama campaign, yielding strong correlations (R>0.96 for different wavelengths) and low root-mean-square error (RMSE<0.01), within the expected error margins for AERONET ground-based sites and benefiting from the continue tracking system implemented for ship-adapted version. Additionally, recurrent comparisons with the ground-based AERONET site at Saint-Denis (La Réunion) further confirm the system's accuracy, presenting good correlations despite differences in altitude and the greater influence of local urban aerosols in Saint-Denis. Retrievals from spectral AOD and sky radiance data collected over the Indian Ocean during a biomass burning event (October 2023) demonstrate the feasibility of deriving detailed aerosol properties, including size distribution and optical characteristics, from shipborne platforms adapted for marine conditions, following the protocols of the AERONET standard algorithm. Observed single scattering albedo (SSA) values, ranging from 0.88 to 0.95 with higher absorption at longer wavelengths, align with those recorded at the Saint-Denis site during the event and are consistent with expectations for a mixture of biomass burning (at the end of the dry season) and sea salt aerosols. These preliminary results underscore the potential of shipborne systems to provide comprehensive aerosol characterization in remote marine environments.

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Fichiers liés : amt-18-4809-2025.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/09/2025
• Auteurs : Priscilla BayleBenjamin AlbouyMathilde AugoyardVincent BalterMarlon BasCédric BeauvalMaryelle BessouMathieu BosqLaurent BruxellesThomas ColardIsabelle CrevecoeurPierre-Jean DodatPauline EhrhardtJean-Philippe FaivreChristophe FalguèresGuillaume GuérinFrançois Lacrampe-CuyaubèreChristelle LahayeAdeline Le CabecMona Le LuyerArnaud LenobleStéphane MadelaineBruno MaureilleXavier MuthCosimo PosthMaïlys RichardHélène RougierAurélien RoyerColette SirieixLuca SitziaAdrien ThibeaultAlain TurqClément Zanolli
• Organismes : De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Université de Montréal De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Austrian Academy of Sciences, Institute for Oriental and European Archaeology Archéosphère Université de Bordeaux De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés School of Geography, Archaeology and Environmental Studies [Johannesburg] De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Éco-Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Histoire naturelle de l'Homme préhistorique IRAMAT-Centre de recherche en physique appliquée à l’archéologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Archéosciences Bordeaux Harvard University Department of Human Evolution [Leipzig] European Synchrotron Radiation Facility De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Musée National de Préhistoire De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Get In Situ Senckenberg Centre for Human Evolution and Palaeoenvironment Muséum national d'Histoire naturelle De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Service Anthropologie et Préhistoire [Bruxelles] De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Laboratoire Paléobiodiversité et Evolution Biogéosciences [UMR 6282] Institut de Mécanique et d'Ingénierie de Bordeaux De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Musée National de Préhistoire De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie

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Résumé : While neighboring regions have yielded numerous Neandertal remains, few discoveries have been reported from the limestone plateaus of the Quercy region in France [1]. However, the accidental discovery in 2006 of a Neandertal-like hemimandible and a deciduous tooth by a speleologist in Sirogne Cave — located within a Jurassic karst system in the northern part of the Alzou Canyon near Rocamadour (Lot, France) — prompted six excavation seasons between 2013 and 2018. These aimed to better understand the chronology, modes of Neandertal occupation, and biological evolution of the populations using the site. The excavations clarified the context of the 2006 discovery and revealed a partially disturbed stratigraphy, affected by recent human interventions. Nevertheless, several preserved layers, covered by stalagmitic floors along the western wall of the cave, were identified. Most notably, nearly 100 human fossils were unearthed from the cave, representing at least 10 individuals: Three children (aged 3–8 years), two adolescents, three young adults, and two older adults. The remains include two hemimandibles (one immature, one adult), over 80 isolated teeth, and infracranial elements. Although most come from sediments affected by post-depositional processes, all exhibit unambiguous Neandertal features. Several infracranial bones show cut marks indicative of dismemberment and disarticulation, suggesting complex mortuary behaviors. The reworked layers also contained faunal remains from over 20 taxa, reflecting a broad but clearly Pleistocene spectrum resulting from both natural and anthropogenic accumulations. More than 2,000 lithic artefacts in quartz, flint, and limestone were also recovered, pointing to at least two Paleolithic techno-complexes: one attributed to the Middle Paleolithic and another to the end of the Last Glacial Maximum. Moreover, Sirogne may correspond to the “Crozo del Dua” cave excavated in the early 20th century by André Niederlander, which yielded five isolated Neandertal teeth and a lithic assemblage [1-3]. Our reanalysis of his faunal collection led to the identification of two additional Neandertal remains — a phalanx and a lower permanent canine — morphologically consistent with the Sirogne material. Combined geological, taphonomic, biochronological, and absolute dating of the stalagmitic floors and associated sediments place the Neandertal fossils within Marine Isotope Stage (MIS) 6, most probably at the end of the Middle Pleistocene (ca. 150,000–130,000 years ago), which represents a critical, yet poorly documented, phase in Neandertal evolutionary history [4]. Morphometric analyses of the teeth and mandibles suggest that the Sirogne individuals are more closely aligned with early Neandertals (pre-MIS 5) than with later groups. They exhibit classic Neandertal features and share affinities with Middle Pleistocene fossils based on external dental dimensions, enamel-dentine junction (EDJ) shape, and non-metric dental traits. Additionally, the low inter-individual variation in EDJ morphology indicates significant biological homogeneity within the Sirogne group. This homogeneity appears even greater than that observed at the Krapina MIS 5e site (Croatia), possibly reflecting regional isolation during MIS 6. Altogether, this exceptional assemblage offers rare and crucial insights into 18 population dynamics and evolutionary processes during a key period in Neandertal history. The evidence supports a model of strong group structuring and complex demographic patterns in Europe prior to 120,000 years ago [4]. Further analyses are currently underway, including attempts at ancient DNA extraction, calcium isotope studies for dietary reconstruction, and SR-microCT imaging of dental microstructures to explore growth patterns and developmental stress. A new three-year excavation project will further refine the chronocultural context and clarify the processes underlying the accumulation of human remains at the site.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 24/09/2025
• Auteurs : Alexandre DurrmeyerJean-Christophe PalauquiPhilippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : The positioning of new cellular walls during cell division plays a key role in shaping plant tissue organization. The influence of cell geometry on the positioning of division planes has been previously captured into various geometrical rules. Accordingly, linking cell shape to division orientation has relied on the comparison between observed division patterns and predictions under specific rules. The need to define a priori the tested rules is a fundamental limitation of this hypothesis-driven approach. As an alternative, we introduce a data-based approach to investigate the relation between cell geometry and division plane positioning, exploiting the ability of deep neural network to learn complex relationships across multidimensional spaces. Adopting an image-based cell representation, we show how division patterns can be learned and predicted from mother cell geometry using a UNet architecture modified to operate on cell masks. Using synthetic data and A. thaliana embryo cells, we evaluate the model performances on a wide range of diverse cell shapes and division patterns. We find that the trained model accounted for embryo division patterns that were previously irreconcilable under existing geometrical rules. Our work shows the potential of deep networks to understand cell division patterns and to generate new hypotheses on the control of cell division positioning.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/09/2025
• Auteurs : Nicolas MartinJean-Pierre ChevalletPhilippe Mulhem
• Organismes : Modélisation et Recherche d’Information Multimédia [Grenoble] PEEKTORIA Modélisation et Recherche d’Information Multimédia [Grenoble] Modélisation et Recherche d’Information Multimédia [Grenoble]

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Résumé : To enhance annotation efficiency in 3D dental Cone Beam Computed Tomography (CBCT) image segmentation, this paper explores an active learning (AL) approach that leverages nnU-Net predictions to generate prompts for a specialized 3D Segment Anything Model (SAM). The objective is to minimize the annotation burden without relying on prompts during the inference phase. First, our experiments showed that AL offers similar segmentation performance with less than 20% of the original annotations. Second, random selection offers similar results than more complex sampling method with less more computing demand. Third, the predictions of nnU-Net on unannotated images provided effective prompts for the SAM model specialized in 3D medical images (i.e., SAM-Med3D). Combining these two approaches reduced the required amount of manual annotation by up to 50%. This paper paves the way for more easily obtaining new annotated datasets in the dental domain while simultaneously training a segmentation model, by leveraging SAM-like models.

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Fichiers liés : MICCAI2025_SAM3D_camera_ready.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 23/09/2025
• Auteurs : Ibrahim Jaser AbualrobShreyasi AcharyaGianluca Aglieri RinellaLuca AgliettaNeelima AgrawalZubayer AhammedShakeel AhmadIshaan AhujaZulkaida AkbarAlexander AkindinovValentina AkishinaMohammad Al-TuranyDmitry AleksandrovBruno AlessandroJose Ruben Alfaro MolinaBushra AliAndrea AliciAnton AlkinJohan AlmeGiacomo AloccoTorsten AltIgor AltsybeevCristian AndreiNicodemos AndreouAnton AndronicEvgeny AndronovMassimo AngelettiVenelin AnguelovFederico AntinoriPietro AntonioliNicole ApadulaHarald AppelshaeuserSilvia ArcelliRoberta ArnaldiJhoao Gabriel Martins Campos Almeida ArneiroIonut Cristian ArseneMesut ArslandokAndre AugustinusRalf Peter AverbeckMohd Danish AzmiHitoshi BabaAkash Raj John BabuAngela BadalaJoonsuk BaeYunseul BaeYongwook BaekXiaozhi BaiRaphaelle Marie BailhacheYoshini BailungRenu BalaAlberto BaldisseriBartosz BalisShubham BangaliaZarina BanooVeronika BarbasovaFrancesco BarileLuca BarioglioMaria BarlouBanajit BarmanGergely Gabor BarnafoldiLee Stuart BarnbyEmilie Martine BarreauValerie Ramillien BarretLeonardo Barreto de Oliveira CamposKlaus BarthEsther BartschNicole BastidGuillaume BatigneDaniel BattistiniBoris BatyunyaDibakar BauriJose Luis Bazo AlbaIan Gardner BeardenPascal BechtDebadatta BeheraSwadhin BeheraIouri BelikovValerio Di BellaFrancesca BelliniRene BellwiedLucina Gabriela Espinoza BeltranYael Antonio Vasquez BeltranGyula BencediAdel BensaoulaStefania Maria BeoleYaroslav BerdnikovAnastasia BerdnikovaLuisa BergmannLorenzo BernardinisLatchezar BetevPartha Pratim BhaduriTushar BhallaAnju BhasinBuddhadeb BhattacharjeeSumit BhattaraiLivio BianchiJaroslav BielcikJana BielcikovaAnte BilandzicAnna BinoyGabor BiroSaikat BiswasDmitry BlauMihail Bogdan BlidaruNora BluhmeChristoph BlumeFriederike BockTea BodovaLaszlo BoldizsarMarek BombaraPeter Matthew BondGermano BonomiHerve BorelAlexander BorissovAndres Gerardo Borquez CarcamoElena BottaYoussef El Mard BouzianiDiana Catalina BrandiburLars BratrudPeter Braun-MunzingerMarco BregantMichal BrozGiuseppe Eugenio BrunoValentin Dimitrov BuchakchievMatthew Daniel BucklandHenner BueschingStefania BufalinoPaul Alois BuhlerNazar BurmasovEdith Zinhle ButheleziAleksandr BylinkinChristopher Alfred CarrJuan Carlos Cabanillas NorisMaria Fernanda Torres CabreraHelen Louise CainesAlberto CalivaErnesto Calvo VillarJuan Manuel Mejia CamachoPaolo CameriniMaria Teresa CamerlingoFabio de Moraes CanedoStefano CannitoSierra Lisa CantwayMihai CarabasFrancesca CarnesecchiLeopoldo Abranches de CarvalhoJavier Ernesto Castillo CastellanosMatteo CastoldiFabio CatalanoSamuele CattaruzziRebecca CerriIrakli ChakaberiaPritam ChakrabortyJustin Wei Ong ChanSinjini ChandraSylvain ChapelandMarielle ChartierSouvik ChattopadhayMeiyi ChenTiantian ChengCvetan Valeriev CheshkovDavide ChiapparaVasco Miguel Chibante BarrosoDavid Dobrigkeit ChinellatoFabrizio ChinuEmma Sophia ChizzaliJaeyoon ChoSoyeon ChoPeter ChochulaZuzanna Anna ChochulskaPanagiotis ChristakoglouChristian Holm ChristensenPeter ChristiansenTatsuya ChujoMario CiaccoCorrado CicaloGabriele CimadorFederico CindoloFabio Filippo ColamariaDomenico ColellaAngelo ColelliManuel ColocciMatteo ConcasGustavo Conesa BalbastreZaida Conesa del ValleGiacomo ContinJesus Guillermo Contreras NunoMaurice CoquetPietro CorteseMauro Rogerio CosentinoFilippo CostaSusanna CostanzaPhilippe CrochetMaciej Marek CzarnynogaAndrea DaineseGautam DangeMeike Charlotte DanischAndrea DanuProttay DasSupriya DasArchita Rani DashSadhana DashAnnalisa de CaroGiacinto de CataldoJan de CuvelandAlessandro de FalcoDaniele de GruttolaNora de MarcoChiara de MartinSalvatore de PasqualeRohaan DebRaffaele del GrandeLuigi Dello StrittoGeovane Grossi Araujo de SouzaPreeti Dhankher LesserDomenico Di BariMarcello Di CostanzoAntonio Di MauroBenedetto Di RuzzaBatoul DiabYanchun DingJanik DitzelRoberto DiviaUliana DmitrievaAlexandru Florin DobrinBenjamin DonigusLars DopperJan Michal DubinskiAndrea DublaPascal DupieuxNatalia DzalaiovaTabea Maria EderRaymond James EhlersFlorian EisenhutRen EjimaDomenico EliaB. 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• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont

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Résumé : A central question in strong-interaction physics, governed by quantum chromodynamics (QCD), is whether femto-scale droplets of quark$-$gluon plasma (QGP) form in small collision systems involving projectiles significantly smaller than heavy ions. Collisions of light ions such as $^{16}$O and $^{20}$Ne offer a unique opportunity to probe the emergence of collective behavior in QCD matter. This Letter presents the first measurements of elliptic ($v_2$) and triangular ($v_3$) flow of charged particles in $^{16}$O$-$$^{16}$O and $^{20}$Ne$-$$^{20}$Ne collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_{_{\rm NN}}} = 5.36$ TeV with the ALICE detector. The hydrodynamic model predictions, explicitly incorporating the nuclear structures of $^{16}$O and $^{20}$Ne, exhibit a good agreement with the flow measurements presented. The observed increase of $v_2$ in central Ne$-$Ne collisions relative to OO collisions, driven by the nuclear geometries, highlights the importance of utilizing light nuclei with well-defined geometric shapes to constrain the initial conditions. These findings support the presence of nuclear geometry-driven hydrodynamic flow in light-ion collisions at the LHC.

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