Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 20/08/2025
• Auteurs : Mikael FinocoMourad Ould-SlimaneLaura Marie-HardyMathieu de SezeEmmanuelle Chaleat-ValayerIsabelle CourtoisBenjamin BouyerYann Philippe CharlesFrançois RannouPierre GuiguiChristelle NguyenEmmanuelle Ferrero
• Organismes : Hôpital Européen Georges Pompidou [APHP] Centre d’études des transformations des activités physiques et sportives CHU Pitié-Salpêtrière [AP-HP] Université Sorbonne Paris Cité Bordeaux population health Centre Médico-Chirurgical de Réadaptation des Massues Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital Haut-Lévêque [CHU Bordeaux] Hôpital de Hautepierre [Strasbourg] Service de rééducation et de réadaptation de l'appareil locomoteur et des pathologies du rachis [CHU Cochin] Hôpital Européen Georges Pompidou [APHP] Service de rééducation et de réadaptation de l'appareil locomoteur et des pathologies du rachis [CHU Cochin] Health and Functional Exposomics UFR Médecine [Santé] - Université Paris Cité Hôpital Européen Georges Pompidou [APHP]
• Publié dans European Spine Journal le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 19/08/2025
• Auteurs : Adrian CeccatoChristian ScheerRicard FerrerMaria Luisa MartinezBerta CisteróJuan Carlos YébenesJosep TrenadoCarol LorencioAdam LinderDaniela FilipescuEvgeny IdelevichEvangelos Giamarellos-BourboulisAntonio ArtigasA. ScharfAdam LeoniukAdam LinderAdriana CataldoAgata DąbkowskaAgneverszka GłusekAikaterini IoakeimidouAlbertus BeishuizenAldona SzczepańskaAlejandro Martin-QuirosAlejandro RodriguezAlessandra OlivaAlessandro ManfrediAlessia FranceschiAlessio BertiniAlessio MarocciaAlexander KochAlexander NickoAlexandre BleibtreuAli RezaeiAliaksei KazachonakAlicja Bartkowska-ŚniatkowskaAlvise TosoniMarco DaverioAnabela BártoloAnamaria HaraborAnani AkpabieAndrea CarsettiAndrea MagaardAndreas EkmanAndreas HeckerAndreas NowakAndreas OstermeierAndreas PrengelAndreas SielenkämperAndreas ThierbachAndriy KrystopchukAndrzej PihowiczA. Neverk CrombachAngela LiebkeAnita LukicAnja HeymannSebastian BaßelerAnja-Tamara LangeAnna Antes-ŻupaAnna EfthymiouAnna EklundAnna LukaszewskaAnna MeuronenAnna RadlińskaAnna Rekas-DudziakAnnelies TacxAnni PulkkinenAnnmarie LassenAntonella FrattariAntonella ViolaAntonio CarneiroAntti MäkeläArion-Björn PaulusArmin SablotzkiArmin SeibelArne RöhrsAthanasios ChalkiasAxel NeverrhausB. AnuszkiewiczBalazs KadarBartolo MichelangeloBenjamin SaskoBernd MüllejansBernhard BirmesBerta CisteróBirgit GottschlichBiserka Mustac-HlebecBjörn JäschkeBoris SakakushevBozidar DuplancicBruno van HerendaelBushra IbrahimAnna ManssonCaitriona RaynerCalancia CosminCarla HopperCarles TriginerCarlo PallottoCarmen LauterbachCarolina RomeroCaroline RiskeCaterina GentiliChristian ByhahnChristian KeunekeChristian PrauseChristian SchlottkeChristina LydonChristine WeisChristoph BüttnerChristoph DodtChristoph PeterChristoph PlankChristophe AvelineCinzia BarlettaClaudia GutscheClaudia HolzbauerConstantin BodoleaCordula ThörmerJohan CourjonCristian CobilinschiCristina HonoratoCsaba KopitkóDagmar EngemannDan CorneciDaneverl BenderDaneverla IonescuDaneverle OrsoDavid HonanDavid MíraDietmar DörschnerDietrich KellerDimitrios SchizasDimitris BliampliasDirk HinzDirk MeiningerDjillali AnnaneAstrid SchwurackDokoula CarineDominik EinwagDorel SandescIlse van CotthemEefje VerwulgenElena ChircovEleni KarlaftiElina RiihiojaElisabeth MontelEls-Marie RolénErica SermijnEtienne JavouheyEva SchadenEveny WinklaarEvgeni DimitrovEvgeni NikolaevEvy VoetsEwa ZabulF. Xavier López AltimirasFabio CaramelliFabrizio DacapitoFausto CatenaFerran LlopisFilip AbedinovFilip TriestFilippia NikolaouFilippo LucianiFiona MooreFlorian BerteauFlorian PrätschFlorian SchacheFlorian SeidlitzFrancesca GrecoFrancesca LelliFrancesco FleresFranco ApraFrank FröhlichFrank HendrichFrank SchleibachFrank WolffgrammFrank ZoernerFrank-Günter MewesFrank-R. KlefischFredrik SchiölerFriedrich AfflerbachFritz-Ulrich HahneGabor NardaiGabriel ChiriacGabriele RacanelliGabriele WolzGabriella BottariGabriella ParisiGarri SlobodianiukGenoveva CadarGeorg FritzGeorg KreuzerGeorge NotasGeorge SakkaGeorgi PopivanovGerd KlinkmannGiacinto IdaGiannini MicheleGideon LattenGiovanna MaddalenaGisa AndresenGiuseppe BrisindaGiuseppe LauriaGoffredo AngioniGöran StenlundGrzegorz PłońskiGünther OpreaH.A.H. KaasjagerH.R. BoumaHaitham MutlakHakan EkvallHana ChmelíčkováHannes GabrielHassold NolanHauke RensingHeike Schlegel-HöfnerHeiko GrothHeiner RuschulteHeinrich GroesdonkHendrik RüddelHenning JansenHenrik RueffertIacopo CappelliniIbolya TothIlka SchanzIlles Hajnal-GabrielaIoana GrigorasIoannis OrfanosIrena OsojnikIreneusz RzepneverwskiIris KlausIris KoperIulia BagiuIulia-Roxana MorlovaIvan HeroldIvana PavlićIvo SchindlerIzzaddin MohdJ. KraßlerJ. Miquel MoralesJacek ProkopowiczJacob PackmohrJacobien HoogerwerfJakub BilskiJan BenešJan BreulsJan CastanJan FričJan MersmannJan RoesnerJan SeemannJan ZatloukalJan-Hinrich BaumertJan-Jakob MeyerJana Fastnacht-BöttcherJana ProtzelJanos SzederjesiJanusz GruszczykJanusz MichalakJaroslav HouserJarosław JancJarosław LubońskiJavier HermidJavier PilarJean-Louis VincentJ.P. LanoixJelmer AlsmaJens DöffertJens ErikssonJens HeidrichJens SoukupJeppe Sa NeverlsenJeremie PasquierJesper SveforsJiří DvorskýJiří KlimešJiří PařízekJiri ZurekJoanna BartczakJoanna ZorskaJohan BerkiusJohan LindströmJohann KnotzerJohanna HästbackaJohannes RheinJolanta WierzchowskaJona WeißkirchenJonas Sunden-CullbergJonas TverringJörg EngelJörg KappertJörg RehlinghausJosep TrenadoJudit KovacsJulika SchönKarel MaelegheerKarina Stefańska-WronkaKarl ReiterKatarzyna BaścikKatarzyna SkawińskaKatia DonadelloKatja MasjosthusmannKay-Lars Müller-ForteKelly StrakaKen DewitteKerstin Achmus-StenzKim JieKitty SliekerKlaus KogelmannKnut MauermannKnut MüllerKoronakis NikolaosKresimir OremusKuido NõmmLars LjungströmLars WittLaura PopaLaura RyanLavinia IonescuLenneke van Lelyveld-HaasLeo LicariLiana ValeanuLibor ZahradníčekLine SamuelssonLisa MellhammarLiudmila HasakLivia VladoiuLudger KämmerlingLuigi BonavinaLuis EnsenatLukas BarnasLukas LörincŁukasz OlendrzyńskiŁukasz RakLupe CoronelLutz PfeifferM. GryskovaM. SchülerMaarit HultMaciej GaworMagdalena MiulescuMagdalena WujtewiczMalgorzata Mikaszewska-SokoleiwczMalte MorisseMeyer-Barner Meyer-BarnerFilippo FilippoManfred HoeflerManfred NuschelerManole-Palivan Corina-CeciliaMarc BeckersMarc BotaMarco BarchettiMarco IngrossoMarco RipaMaria AnderssonMaria FortofoiuMaria ZachMariana AngheleMario GuarinoMariola MaciaszekMariola TałałajMarius PapuricaMark NeufangMarkus BresslerMarkus EllerMarkus KestlerMarkus KredelMarkus RudnickMarkus TeipelMartijn van TellingenMartin BeiderlindenMartin BierMartin CermakMartin EbertMartin HelanMartin KahlMartin MetelkaMartin ReichertMartin SchützMartin SpångforsMartin WagnerMartina ČehulićMartina PavletićMarton GyengeMary BeddingMarzouk MehdiMaša BiberičMateusz MiszczyszynMathias FischerMathias SprengerMatija BelavićMatija JurjevićMatjaž GroznikMatthias GründlingMatthias HuckMatthias LutzeMatthias MenzelMatthias SchmaußMatthias WeißMaurizio MazzoniMax MüllerJochen SouquetMaximilian RagallerMichael BookeMichael BuerkeMichael Dalager-PedersenMichael DolchMichael FriesMichael HabenichtMichael KremerMichael MeisnerMichael MeyerMichael PogatschniggMichael SchützMichael StofkoperMichal HolubMichal PelíšekMichal SitinaMichał ŚpiewakMichał ZiółkowskiMichelle BehanMihaela BlajMihaela ConciMihaela LupseMika ValtonenMikael MoriconiMinaříková DagmarMiroslav ZajicekMohamed HasaballahMoritz UnglaubeMrozek MrozekNádia GuimarãesNahema IssaNathalie LayiosNelson BarrosNicolas BelaubeNicolas MongardonNicolas SerckNikolaas VerbekeNikolas LambirisNikoletta RovinaNils HaakeNina PolzeNina SulenNora BrunsNoud BuenenOjan AssadianOle BrochOlena OliwaOlga KlementováOliver BeckOliver HablerOliver HenselOliver KunitzOliver SchmidOlof BlivikOndrej ZikaOnnen MörerOrestis IoannidisOskar LjungquistPaola RodariPapa RaffaellaPär LindgrenPascal StammetPasquale MinchellaPatricia PatricioPatrik Gille-JohnsonPatrizia PetricciPaula PestanaPaula VeraPavel DostalPavel MalinaPavel SedlákPeter BrandPeter NeumannPetr HubacekPetr StepanekPetr UhligPetra WegermannPhilipp TsafoulisPierre FillâtrePierre TattevinPio FaustPiotr CzempikPiotr SmuszkiewiczPiotr StaneverwskiPlinio CalligaroPolychronis TassioudisPřemysl DörrPrzemysław MichalskiR. KlimaschewskiR. SchnabelRadek CihlářRafał GałuszkaRafał WójtowiczRainer HaasRalf WalperRalph BudnikRalph SanderRaphael GukasjanReiner SitzlerReinoud CartuyvelsRenata SzmigielskaRenate KochRené VerbeekRicard FerrerRicardo CastelbónRob WiltingRobert BocekRobert JandaRoberta MorettiRomain JouffroyR. LarcherRonald SeidelRoxana UngureanRüdiger AlbrechtRüdiger LottRui TerrasRuth MüllerRyszard TokarczukSalla KumpulainenSami MäenpääSandra MüllerSandra DonovanSanna PohjanpajuSara CajanderSascha UssatSaviano AngelaSebastian BrandtSebastian CasuSebastian HafnerSebastian HammerichSebastian RehbergSebastian TrancaSelena KnothShahram MashayekhiShona FitzgeraldSilvana PiliaSimo-Pekka KoivistoSimon OelsnerSimon SchäferSimona BarniniSimona ViolaSimu TudorSinead OneillSiwanczak SiwanczakSöhnke BoyeSonja KrofakSpadaro SavinoStaffan TevellStefan AngermairStefan BergtStefan MarkoffStefan OstmeierStefan OttoStefan WirtzStefan RußwurmStefan SchroederStefan StaarStefanever VanderveldenStefano TrapassiSteffen VolkertStepani BendelStephan BaumannStephan BlacheStephanever KosterStephanever MifsudSunil JagodaSven AckermannSybille GlöcklT. DormansTalvikki KoskueTatiana CiomartanTeresa TomasaTheodoros AslanidisThessa VerneverstThomas EckermannThomas GrauThomas HahnThomas KissThomas LibudaThomas MelzerThomas RöselThomas UhligThomas VolkThomas WeidermannThorsten KeilTim BruckmoserTim PiephoTimmermans MarkTina FroloToamas GabrhelikTobias GroppTobias KlöpperTobias LahmerTobias LeipoldTomáš MálekTomáš TajčTomas UrbinaTomas VymazalTomasz MusiukTomasz SiegelTomasz SkalecTorsten FrickeUdo GottschaldtUlf LinstedtUlrich BlumenthalUlrich KattUlrich PlogUlrich RonellenfitschUrsula GeorgeUte BrüggemannUwe TreueVáclava AdámkováValeria CaramelloVasileios KaldisVasileios NolasVasilios PapaioannouVerena PlötzVesna DegoricijaViktor ŠvigeljVille JalkanenVladimír ZemánekVolker OstermoorW. Alexander OsthausW. Joost WiersingaW.B. HuiszoonWahid AltafWaldemar SobolewskiWalravens StigWalter StadlmeyerWiktoria MizakWitold WasiakWojciech DabrowskiWolfgang HeinkeWolfgang ZinkXavier MuschartYuriy BuninYvo BouéYvonne YoungZdenek KosZdenko Povšić-ČevraZuzanna Górska
• Organismes : Hospital Universitari Parc Taulí de Sabadell [Barcelona, Spain] University of Medicine Greifswald Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona Hospital Universitari Parc Taulí de Sabadell [Barcelona, Spain] CHU Amiens-Picardie Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
• Publié dans Critical Care le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 18/08/2025
• Auteurs : Nadège NéantMinh LêStéphane BouchetJennifer Lagoutte-RenosiMatthieu GrégoireFrançois ParantNicolas VenisseSébastien LalanneFlorian LemaitrePatrice MuretQuentin RenouAlexandre DesterePeggy GandiaPhilippe FlandreGilles PeytavinCaroline SolasBenoît BaillyVincent GendrinTimothée KlopfensteinSouheil ZayetFabienne BozonAnne-Sophie BrunelBruno HoenLaurent Hustache-MathieuMojgane HemssamfarFabrice BonnetLionel PirothMarielle BuissonSophie MahyMichel DuongMary-Anne TrabaudDulce AlfaiateAgathe BeckerEvelyne BraunFlorence BrunelMatthieu GodinotThomas PerpointClément JavauxPhilippe ColsonAnne MotteVéronique Obry-RoguetSylvie BrégigeonOlivia Faucher-ZaegelHélène LarocheMaeva dos SantosIsabelle RavauxCatherine DhiverChristelle TomeiAmélie MénardMatthieu MillionPatrick PhilibertChristina PsomasSimona-Loredana BerbescuCatherine MichelThomas DrumelClotilde AllavenaEric BillaudSabelline BouchezCécile Brunet-CartierColin DeschanvresFrançois RaffiVéronique ReliquetGwennaelle QuerneCécile Mear-PassardAntoine AsquierCharlotte MoyonVirginie BeslonLio ColliasVincent CalvezDiane DescampsValentine FerréYazdanpanah YazdanJade GhosnValérie PourcherMarc-Antoine ValantinDavid PlainchampFrançois BenezitCédric ArvieuxChristine CheneauAxel UrsenbachBaptiste HoellingerCéline MelounouDavid ReyYves Hansmann
• Organismes : Unité des Virus Emergents Infection, Anti-microbiens, Modélisation, Evolution Bordeaux population health Assessing Health in a Digitalizing Real-World Setting Pharmacoepi & beyond Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Hospices Civils de Lyon Écologie et biologie des interactions [UMR 7267] Interaction Homme Environnement Santé [Équipe du laboratoire EBI Poitiers] Institut de recherche en santé, environnement et travail Institut de recherche en santé, environnement et travail Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) Unité des Virus Emergents Laboratoire Jean Alexandre Dieudonné Innovations Thérapeutiques et Résistances Institut Pierre Louis d'Epidémiologie et de Santé Publique Infection, Anti-microbiens, Modélisation, Evolution Unité des Virus Emergents Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
• Publié dans Clinical Infectious Diseases le 30/10/2020

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Résumé : The impact of pharmacokinetic variability of cabotegravir (CAB) and rilpivirine (RPV) long-acting (LA) injectable therapy on virological outcomes remains controversial. This study aimed to characterize the variability of CAB and RPV trough concentrations (C-trough) and to identify the predictors of suboptimal exposure and virologic failure (VF) in a large real-world cohort. Methods. We conducted a multicenter observational study including people with human immunodeficiency virus type 1 (HIV-1) initiating LA-CAB/RPV as maintenance therapy from January to December 2022, in whom CAB and RPV plasma C-trough were determined as part of therapeutic drug monitoring (TDM). Results. A total of 1674 CAB and 1687 RPV C-trough measurements were collected from 736 people with HIV-1 (PWH). Significant interindividual variability in concentrations was observed. At month 1/month 3, 20%-30% of PWH had C-trough <1120 ng/mL for CAB and 32 ng/mL for RPV. Predictors of lower C-trough were body mass index (BMI) >= 30 kg/m(2) and female sex at month 1, and only male sex at steady state. After a median follow-up of 12 (interquartile range, 9-16) months, VF occurred in 2.5% of PWH. At month 6 and month 12, VF was significantly associated with the presence of at least 2 risk factors (obesity, suboptimal C-trough) (odds ratio [OR], 4.6, P = .047; OR, 5.15, P = .014), and CD4 nadir (OR, 0.56, P = .008; OR, 0.5, P = .001). Conclusions. Our large real-world study confirms significant variability in CAB and RPV exposure, with BMI and sex as key predictors of lower C-trough. Suboptimal CAB and RPV C-trough, particularly in people with obesity, increases the risk of VF during the first year of treatment, highlighting the usefulness of TDM in clinical practice.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/08/2025
• Auteurs : João Gomes da SilvaElisa Delgado-MenaN. SantosTelmo MonteiroPierre LarueAlejandro Suárez MascareñoXavier DelfosseLucille MignonÉtienne ArtigauNicola NariManuel AbreuJosé AguiarKhaled Al MoullaGuillaume AllainRomain AllartTomy ArialHugues AugerFrederique BaronS. BarrosLuc BazinetBjörn BennekeNicolas BlindDavid BohlenderIsabelle BoisseXavier BonfilsAnne BoucherFrançois BouchyVincent BourrierSébastien BovayPedro BrancoChristopher BroegDenis BrousseauVincent BruniquelMarta BryanAlexandre CabralCharles CadieuxBruno Canto MartinsAndrés CarmonaYann CarteretZalpha ChallitaBruno ChazelasRyan CloutierJoão CoelhoMarion CointepasUriel ConodNeil James CookAna Rita Costa SilvaNicolas CowanEduardo CristoAntoine Darveau-BernierLaurie DauplaiseRoseane de Lima GomesJose Renan de MedeirosJ.-B. DelisleDhvani DoshiRené DoyonXavier DumusqueDavid EhrenreichPedro FigueiraDasaev FontineleThierry ForveilleYolanda FrenschJonathan GagnéFrédéric GenestLudovic GenoletJ. HernándezJennifer GloverFélix Gracia TémichNolan GrievesNicole GromekOlivier HernandezM. HobsonH. Jens HoeijmakersNorbert HubinFarbod JahandarRay JayawardhanaHans-Ulrich KäuflDan KerleyJohann KolbVigneshwaran KrishnamurthyBenjamin KungAlexandrine L’heureuxDavid LafrenièrePierrot LamontagneIzan de Castro LeãoHenry LeathOlivia LimJustin LipperGaspare Lo CurtoChristophe LovisLison MaloAllan MartinsJaymie MatthewsJean-Sébastien MayerClaudio MeloLina MessamahYuri MessiasStanimir MetchevLeslie MorantaChristoph MordasiniDany MounzerGeorgia MrazLouise NielsenAres OsbornJon OtegiMathieu OuelletLéna ParcLuca PasquiniV. M. PasseggerStefan PelletierFrancesco PepeCéline PerouxCaroline Piaulet-GhorayebMykhaylo PlotnykovEmanuela PompeiAnne-Sophie Poulin-GirardJosé Luis RasillaRafael ReboloVladimir ReshetovJason RoweJonathan Saint-AntoineMirsad SarajlicIvo SavianeRobin SchnellAlex SegoviaDamien SégransanJulia V. SeidelArmin SilberPeter SinclairMichael SordetDanuta SosnowskaAvidaan SrivastavaAtanas StefanovMárcio TeixeiraSimon ThibaultStéphane UdryDiana ValenciaPhilippe ValléeThomas VandalValentina VaulatoGregg WadeJoost WardenierBachar WehbeDrew WeissermanIvan WeversFrançois WildiVincent YarivGérard Zins
• Organismes : Instituto de Astrofísica e Ciências do Espaço Instituto de Astrofísica e Ciências do Espaço Departamento de Física e Astronomia [Porto] Institut de Planétologie et d'Astrophysique de Grenoble Institut de Planétologie et d'Astrophysique de Grenoble Institut de Planétologie et d'Astrophysique de Grenoble Université de Montréal Université de Montréal Université de Montréal Institut Trottier de Recherche sur les Exoplanètes Instituto de Astrofísica e Ciências do Espaço Département de Physique [Montréal] Laboratoire d'Astrophysique de Marseille Institut de Planétologie et d'Astrophysique de Grenoble Institut de Planétologie et d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Marseille Institut de Planétologie et d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Marseille European Southern Observatory Institut de Planétologie et d'Astrophysique de Grenoble European Southern Observatory
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context. Stellar activity variability is one of the main obstacles to the detection of Earth-like planets using the radial velocity (RV) method. Aims. The aim of this work is to measure the effect of activity in the spectra of M dwarfs and detect activity-sensitive lines in the near-infrared (NIR) to help improve exoplanet detection and characterisation and contribute to further stellar activity analysis in the NIR. Methods. We took advantage of the simultaneous observations of HARPS and the newly commissioned NIRPS spectrograph to carry out a blind search of the most activity-sensitive spectral lines in the NIR using NIRPS spectra and known activity indicators in the optical from HARPS as a reference. We analysed the spectra of Proxima (M5.5V) and Gl 581 (M3V), two M dwarfs with different activity levels and internal structures. Spectral lines were identified for both stars and their profiles were fitted using different models. Results. We found hundreds of lines sensitive to activity for both stars; the Proxima spectra were more affected. For Proxima, around 32% of the identified lines can be used to measure the rotation period of the star, while for Gl 581 the numbers drops to 1%. The fraction of lines sensitive to activity increases with increasing line depth for both stars. A list of 17 lines with rotation period detection for both stars is provided. Conclusions. Stellar activity is able to affect a significant number of spectral lines in the NIR, and methods should be developed to mitigate those effects at the spectral level. The line distortions detected here are expected to come mainly from the flux effect due to temperature contrasts between active regions and the quiet photosphere; however, we cannot rule out the possibility that core-emission from chromospheric activity or Zeeman splitting are also affecting some lines. The new line lists presented here can be used to improve the RV extraction and the detection of RV variability due to stellar activity signals, and to help false positive detection and the modelling of activity variability, thereby enhancing exoplanet detection in the NIR.

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Fichiers liés : aa55013-25.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 13/08/2025
• Auteurs : Philippe Bootz
• Organismes : Laboratoire Paragraphe Université Paris 8

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Résumé : Cet article se concentre sur certains aspects de la poésie numérique programmée. Dans une première partie, il présente quelques formes : la conception non standard de l'hypertexte de Jim Rosenberg, le syntexte et la première théorie du wreader de Pedro Barbosa, la génération automatique de texte par Jean-Pierre Balpe et sa théorie du méta-auteur, la conception processuelle de la génération mise en œuvre dans la poésie cinétique, l'animation syntaxique. Dans une deuxième partie, l'article montre que ces formes remettent en question la conception de la lecture en accordant un rôle prédominant au point de vue que peut avoir un lecteur. Plusieurs concepts sont proposés pour prendre en compte ces points de vue dans une théorie de la lecture, et la lecture attentive d'un poème cinétique programmé montre comment ils peuvent être utilisés dans l'analyse.

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Fichiers liés : echinox FR.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/08/2025
• Auteurs : Pierre GroussinMelvyn DezecotDonovan DecaudinDominique PavinSandro NinniCédric KleinPierre OllitraultLaure Champ-RigotJonaz FontAntoine da CostaJean-Marc SellalNéfissa HammacheAlexandre SalaunCharles GuenanciaPhilippe MaboKarim BenaliRaphaël P Martins
• Organismes : Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
• Publié dans JACC: Clinical Electrophysiology le 31/10/2020

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Résumé : BACKGROUND: Therapeutic strategies for electrical storm (ES) in patients with hypertrophic cardiomyopathy (HCM) are not well defined, yet this population is at risk for ventricular arrhythmias (VAs). OBJECTIVE: The aim of this study was to analyze acute management, in-hospital mortality, and long-term outcomes of patients with HCM experiencing ES. METHODS: This multicenter study retrospectively enrolled patients with ES complicating HCM between 2017 and 2023 in 6 tertiary centers. RESULTS: Twenty-three patients were included (mean age 61.5 ± 15.2 years, 73.9% male, left ventricular ejection fraction 50% ± 14%). Five patients (22%) had an apical aneurysm. Ten (43.4%) patients had a history of VA, including 3 with previous ES. The majority of VAs were monomorphic ventricular tachycardias (18 patients [78%]). Most patients received amiodarone (n = 20 [87%]) and beta-blockers (n = 16 [70%]). For 10 patients (44%), a radiofrequency catheter ablation was performed (including 2 endo-epicardial ablations), resulting in negative programmed ventricular stimulation in 4 patients. During their hospital management, 8 patients experienced recurrences of VA (2 [25%] previously ablated and 6 [75%] nonablated). Two (9%) patients died during the index hospitalization and 4 other patients died following discharge (median follow-up 18 months). Seven patients (30%) experienced recurrences of arrhythmias, including 4 who had undergone ablation. Radiofrequency ablation was not associated with better outcomes (recurrence rate or overall survival) in this study. CONCLUSIONS: ES in HCM frequently resolves using antiarrhythmic drugs. Many patients will present with VA recurrences. Long-term outcomes were poor, and one-fourth of the patients ended up dying at 18 months. Further studies are warranted to better analyze radiofrequency outcomes in this specific population.

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• Type de publi. : Article dans une revue
• Date de publi. : 07/08/2025
• Auteurs : Oscar WernerMarion PouzencHelena HuguetBertrand LeobonMarie-Christine C PicotGrégoire de La VilléonMarie VincentiAlban-Elouen BaruteauMohamed LyCaroline OvaertVirginie FouillouxPhilippe AcarClément KarsentyFrançois RoubertieJean-Benoit ThamboSophie GuillaumontPascal Amedro
• Organismes : Centre de Référence Malformations Cardiaques Congénitales Complexes Institut Saint-Pierre Centre de Référence Malformations Cardiaques Congénitales Complexes Institut Saint-Pierre CHU Montpellier = Montpellier University Hospital CHU de Bordeaux Pellegrin [Bordeaux] Université de Bordeaux CHU Montpellier = Montpellier University Hospital Centre de Référence Malformations Cardiaques Congénitales Complexes Institut Saint-Pierre Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Physiopathologie des Adaptations Nutritionnelles ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Marseille medical genetics - Centre de génétique médicale de Marseille Service de cardiologie Pédiatrique [Marseille] CHU Marseille Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Université de Bordeaux Centre Hospitalier Universitaire de Bordeaux Université de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Régional Universitaire [Montpellier] Institut Saint-Pierre Université de Bordeaux Centre Hospitalier Universitaire de Bordeaux
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Objectives: Coarctation of the aorta (CoA) is the most common undiagnosed congenital heart disease during prenatal screening and its overall prognosis relies on the quality of the surgical repair. This study aimed to identify the prenatal and postnatal factors associated with the type of surgical technique repair in infant CoA.Methods: Multicentre, retrospective, observational study in 680 infants (68% males) aged <1 year who underwent CoA surgical repair in 4 CHD surgical centres in France over 11 years. The primary outcome was the surgical repair technique (simple end-to-end repair, extended end-to-end repair, or aortic arch repair).Results: The aortic arch raw diameter, measured by echocardiography just beyond the brachiocephalic arterial trunk, was the most discriminating parameter for the type of surgical repair technique, outperforming the existing Z-scores models. Cut-off value of aortic arch diameter ≤3.6 mm in children < 1 years old was predictive of an aortic arch repair (area under the curve (AUC) [95%CI]=0.76 [0.67;0.86]). In multivariable analysis, a prenatal associated cardiac malformation (odd ratio (OR)[95%CI]=4.39 [1.99 ; 9.69]) and aortic arch diameter ≤3.6mm (OR[95%CI]=3.78 [1.61 ; 8.62]) were predictive of an aortic arch repair.Conclusion: The aortic arch diameter is the most discriminating parameter for the type of surgical repair technique in infant CoA. An aortic arch threshold value of 3.6 mm in infant population is predictive of aortic arch repair and should be considered a practical indicator of the hypoplastic nature of the aortic arch.

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Fichiers liés : O WERNER .pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 05/08/2025
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesThiago TomeiEduardo 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• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon

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Résumé : A reinterpretation of a prior narrow-resonance search is performed to investigate the resonant production of pairs of dijet resonances via broad mediators. This analysis targets events with four resolved jets, requiring dijet invariant masses greater than 0.2 TeV and four-jet invariant masses greater than 1.6 TeV. The search uses a data sample corresponding to an integrated luminosity of 138 fb$^{-1}$ collected by the CMS experiment in proton-proton collisions at $\sqrt{s}$ = 13 TeV. The reinterpretation considers the production of new heavy four-jet resonances, with widths ranging from 1.5 to 10% of their mass, which decay to a pair of dijet resonances. This analysis probes resonant production in the four-jet and dijet mass distributions. Upper limits at 95% confidence level and significances are reported on the production cross section of new resonances as functions of their widths and masses, between 2 and 10 TeV. In particular, at a four-jet resonance mass of 8.6 TeV, the local (global) significance ranges from 3.9 (1.6) to 3.6 (1.4) standard deviations (s.d.) as the resonance width is increased from 1.5 to 10%. This relative insensitivity to the choice of width indicates that a broad resonance is an equally valid interpretation of this excess. The broad resonance hypothesis at a resonance mass of 8.6 TeV is supported by the presence of an event with a four-jet mass of 5.8 TeV and an average dijet mass of 2.0 TeV. Also, we report the reinterpretation of a second effect, at a four-jet resonance mass of 3.6 TeV, which has a local (global) significance of up to 3.9 (2.2) s.d.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Irvin TehKévin MoulinPedro FerreiraJulie AbsilMaryam AfzaliPeter AggerBehnaz AkbariAnthony AletrasSatoru AonoCharles BentonSuryava BhattacharyaPierre CroisilleYves de BrueckerErica Dall’armellinaDaniel EnnisCarl GlessgenAnna GlinskaSandra HaltmeierAriel HannumErik HedströmTawfik HusseinSarah JonesGeorge JoyKaren KettlessWon Yong KimSebastian KozerkeJulie MagatRaja MuthupillaiReza NezafatSonia Nielles-VallespinJohn OshinskiValéry OzenneDudley PennellRoderick PettigrewIain PierceBetty RamanAgnieszka SabiszJürgen SchneiderJanet ShermanAbhishek ShetyeRolf SymonsPhilippe ThomaThomas TreibelSatonori TsunetaJean-Paul ValleeNiels VejlstrupMagalie ViallonChristopher NguyenAndrew ScottChristian Stoeck
• Organismes : IHU-LIRYC Centre de résonance magnétique des systèmes biologiques
• Publié dans Journal of Cardiovascular Magnetic Resonance le 01/11/2020

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Résumé :

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Fichiers liés : Main Manuscript_R1_tracked_changes.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Wissam El-HageAlexandre LeméMyriam BlanchinEric BuiHala KerbageSarah IbouhsissenAude Allemang-TrivalleValérie GissotB.GohierCoraline HingrayPhilippe BirmesEric FakraNathalie PrietoCédric LemogneMarie‐odile KrebsBruno AouizerateIsabelle JalenquesPierre VidailhetAnne SauvagetAgnès Caille
• Organismes : Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [CHRU Tours] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours methodS in Patients-centered outcomes and HEalth ResEarch CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Université de Caen Normandie Centre de recherche en épidémiologie et santé des populations Hôpital Saint Eloi [CHU Montpellier] Centre d’Investigation Clinique [CHRU Tours] Centre d’Investigation Clinique [CHRU Tours] Centre d’Investigation Clinique [CHRU Tours] Centre Hospitalier Universitaire d'Angers SFR UA 4201 Confluences Laboratoire de Psychologie des Pays de la Loire Centre Psychothérapique de Nancy [Laxou] Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy Toulouse NeuroImaging Center Université Jean Monnet - Saint-Étienne Hôpital Edouard Herriot [CHU - HCL] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Hôpital Hôtel-Dieu [Paris] Institut de psychiatrie et neurosciences de Paris Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Institut Pascal Institut national polytechnique Clermont Auvergne CHU Clermont-Ferrand Université Clermont Auvergne Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Universitaire [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre d’Investigation Clinique [CHRU Tours] methodS in Patients-centered outcomes and HEalth ResEarch
• Publié dans Health Expectations le 26/10/2020

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Résumé : Introduction - The Covid-19 outbreak hit the world forcing public institutions to rethink their core functioning. Healthcare workers (HCWs) were particularly at risk for negative mental health outcomes, given their direct exposure to many pandemic-related stressors. Our study aimed to assess the psychological outcomes of French HCWs during the Covid-19 pandemic, including PTSD, depression and burn-out. Methods - This study presents the baseline data of a large cohort study conducted during the pandemic. Participants were 849 French HCWs (mostly single women, working as nurses) assessed for PTSD with the PCL-5 (PTSD Checklist for DSM-5), for depression with the PHQ-9 (Patient Health Questionnaire), and for burn-out and compassion satisfaction with the ProQOL (Professional Quality of Life). Other pandemic-related variables were also collected, including characteristics related to participants' Covid-19 experience, as well as psychological and clinical measures. Results - The prevalence rates of PTSD, moderately severe depression, and high risk for burn-out were 17.7% (n = 146), 14.0% (n = 118) and 0.9% (n = 7), respectively. Further, findings suggested that working conditions were challenging, though they still found pride in their work. Univariate analyses showed that being a woman, not being a physician, and lacking protective equipment were each associated with higher scores on several negative psychological outcomes (PTSD, depression, burn-out and secondary traumatic stress), though not consistently across all dimensions. Notably, satisfaction scores on the ProQOL did not differ by gender and were higher among physicians. In the multivariate analyses, not being a physician was independently associated with higher levels of PTSD, depression and burn-out symptoms. Being a woman was independently associated with increased PTSD symptom severity. Higher levels of positivity-defined as a general tendency to view life and experiences with an optimistic and constructive outlook, as measured by the Positivity Scale-were associated with lower symptom scores across all three psychological outcomes. Conclusion - This study highlights the considerable psychological toll of the Covid-19 pandemic on French HCWs, particularly among nurses and women, and underscores the protective role of individual psychological resources such as positivity. As one of the largest cohort studies conducted during the pandemic in France, it provides critical evidence to guide public health strategies, institutional policies and mental health interventions. The findings emphasise the urgent need to strengthen occupational mental health support systems and to promote resilience-building approaches among healthcare professionals facing prolonged crisis conditions.

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Fichiers liés : Health Expectations - 2025 - El‐Hage - High Psychological Impact of Covid‐19 on French Healthcare Workers An Observational.pdf

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