Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Philippe RyvlinMargaux HuotLuc ValtonLouis MaillardFabrice BartolomeiPhilippe DerambureEdouard HirschVéronique MichelFrancine ChassouxJérôme PetitArielle CrespelArnaud BirabenVincent NavarroPhilippe KahaneBertrand de ToffolPierre ThomasSarah RosenbergAdriano BerniniAnne-Laure CharloisLaura CraciunFatima ChorfaPauline DucouretAxel FerreiraMathilde LeclercqManon MartyBlanca Mercedes AlvarezMilena SampaioAntoine SpahrNoémie Timestit-KurlandMaylis TouyaPascal RoySylvain Rheims
• Organismes : Centre Thématique de Recherche et de Soins - Institut des Épilepsies de l'Enfant et de l'Adolescent = IDEE Epilepsy Institute Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Centre de recherche cerveau et cognition Centre Hospitalier Universitaire de Toulouse Ingénierie Moléculaire, Cellulaire et Physiopathologie Service de neurologie [CHRU Nancy] Institut de Neurosciences des Systèmes Service d'Epileptologie et de Rythmologie Cérébrale [Hôpital de la Timone, AP-HM] Service de neurophysiologie clinique Pharmacologie de la mort neuronale et de la plasticité cérébrale Centre de référence des épilepsies rares [CHU Strasbourg] Service de Neurologie [Strasbourg] Service de neurologie [Bordeaux] Service de neurochirurgie [AP-HP Hôpital Lariboisière] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Centre Médical de la Teppe Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image AP-HP - Hôpital de la Pitié Salpêtrière Institut du Cerveau = Paris Brain Institute [GIN] Grenoble Institut des Neurosciences CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier Régional Universitaire de Tours Inserm U930 Imagerie et Cerveau Service de Neurologie [CHU Nice] Service Neurologie [CHU Clermont-Ferrand] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Hospital General Universitario "Gregorio Marañón" [Madrid] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
• Publié dans The Lancet Neurology le 27/10/2020

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Résumé : Background. Novel biomarkers of the risk of sudden unexpected death in epilepsy (SUDEP) are needed to better inform people with epilepsy of their individual risk and identify those at a high risk. The aim of this study was to identify such biomarkers, particularly with the exploration of seizures characteristics that have not been previously investigated, including peri-ictal peripheral oxygen saturation (SpO2) and site of seizure onset. Methods. We conducted a nested case–control study of SUDEP within a dedicated nationwide prospective cohort. Eligible participants were adults with drug-resistant focal epilepsy undergoing in-hospital seizure monitoring at 16 epilepsy monitoring units in France. Clinical data, results from presurgical investigations, and raw recordings from video EEG, electrocardiogram (ECG), and SpO2 were collected until the end of the recruitment period. The French National Directory of Natural Persons Identification was queried annually to identify deaths. SUDEP cases were adjudicated on the basis of medical records and interviews documenting the circumstances of death. Each SUDEP case was matched to four controls on the basis of study centre and date of inclusion. SUDEP risk factors were identified using LASSO-penalised conditional logistic regression. Findings. From May 18, 2010, to Aug 23, 2015, we enrolled a total of 1074 participants and followed their vital status until the end of 2018, yielding a total of 6828 patient-years of follow-up. 42 participants died during follow-up, including 18 cases of definite or probable SUDEP, resulting in a SUDEP rate of 2·64/1000 patient-years (95% CI 1·36–3·92). Four risk factors were significantly associated with the risk of SUDEP: an extratemporal epileptogenic zone (OR 37·8, 95% CI 3·21–446·2, p=0·0039), a BMI of 30 or higher (26·0, 2·0–339·6, p=0·013), male sex (12·6, 1·5–106·8, p=0·0201), and predominantly nocturnal seizures (6·0, 1·2–28·7, p=0·026). In contrast, the presence of peri-ictal SpO2 of less than 80% during focal seizures, the frequency of focal-to-bilateral tonic–clonic seizures, heart rate variability, age at epilepsy onset, number of antiseizure medications, and history of depression were not significantly associated with SUDEP. Interpretation. Extratemporal epilepsies involving the perisylvian region or frontal lobe appear to be associated with an increased risk of SUDEP. This finding warrants confirmation in larger cohorts and underscores the need to improve the diagnosis and surgical management of extratemporal epilepsies, which might contribute to improved SUDEP risk stratification and prevention.

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Fichiers liés : 1-s2.0-S1474442225003795-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Boris JungMathieu JabaudonAudrey de JongLaurent laurent-bitker BitkerJules AudardKada KloucheBenjamine SartonChristophe GuittonSigismond LasockiBenjamin RieuEmmanuel CanetCaroline JeantrelleAntoine RoquillyJulien MayauxFranck VerdonkJulien PottecherMartine FerrandiereBeatrice RiuPierre GarconMona AssefiPhilippe DetoucheJean Marie ForelClaire Penetrat-RogerJeremy BourenneSophie JacquierDavid BougonAmelie RollePhilippe CorneNacim BenchabaneJean Christophe RichardKarim AsehnouneGerald ChanquesJean-Baptiste LascarrouFoud BelafiaMaxime FossetHelena HuguetEmmanuel FutierNicolas MolinariSamir JaberSonia MachadoVincent BrunotLaura PlatonDelphine DaubinNoémie BesnardValérie MoulaireCorinne PelleLiliane LandreauGuillaume DeneilHodane YonisMehdi MezidiLouis ChauvelotS. SilvaPatrice TirotCedric DarreauNicolas ChudeauMaeva CampfortSoizic GergaudLoris GiordanettoThomas GodetJean-Baptiste LascarrouJean-Baptiste LascarrouMikahel GiabicaniKarim AshenouneYannick HourmantAlexre BourdiolCécile PoulainAlexre DemouleMartin DresMaxens DecavèleMarie LecronierCôme BureauJulien Do ValeSophie MenatSebastien ClercJeremie PichonJennifer CatanoAdam CelierValentine Le StangMarie-Claire DiemozHugo Flis-RichardEmmanuel PardoNatacha KapandjiAlain MeyerStephane HecketsweilerPaer Selim AbbackLy van Phach VongDelphine ReitterJonathan ZarkaJean Michel ConstantinFlorence DavietLaurent MullerJean Yves LefrantStephan EhrmannCharlotte Salmon GinniereLaëtitia Bodet-ContentinJulien CarvelliMarc GainierBernard CholleyJean DellamonicaMathieu JozwiakClement SacchieriAlexandre LautretteMartin CourLaurent ArgaudThomas RimmeleSebastien PreauXavier CapdevilaMaud FiancetteDamien RouxJulien BohePierre AsfarRussel ChabanneNicolas TerziNaïke BigeAude GarneroDjamel MokartHatem Kallel
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nîmes Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans JAMA Cardiology le 25/10/2020

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Résumé : Importance The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute kidney injury is unknown. Objective To determine whether sodium bicarbonate infusion is associated with day 90 all-cause mortality in patients with severe metabolic acidemia and moderate to severe acute kidney injury. Design, Setting, and Participants Randomized, open-label, clinical trial conducted with 640 patients in 43 French intensive care units from October 6, 2019, to December 19, 2023, with 90-day follow-up. The last date of follow-up was June 17, 2024. Adults with severe metabolic acidemia (defined as pH ≤7.20) and moderate to severe acute kidney injury were enrolled. Intervention Patients were randomized 1:1 to receive either intravenous sodium bicarbonate infusion or no sodium bicarbonate to target an arterial pH of 7.30 or higher. Main Outcomes and Measures The primary outcome was day 90 all-cause mortality. Secondary outcomes included day 28 and day 180 all-cause mortality; use of organ support therapy, vasopressors, or invasive mechanical ventilation; intensive care unit and hospital length of stay; intensive care unit–acquired infections; fluid balance; day-7 Sequential [Sepsis-related] Organ Failure Assessment score (6 organ systems’ function is evaluated and scored from 0 [no dysfunction] to 4 [failure]; total score ranges from 0 [normal] to 24 [maximum failure]); and major adverse kidney events on day 90. Results Among 640 randomly assigned patients, 627 were analyzed (313 in the control group and 314 in the bicarbonate group). The median age was 67 years (IQR, 59-74 years); 194 of 314 patients (62%) in the bicarbonate group and 185 of 313 controls (59%) were male. In the primary analysis, day 90 all-cause mortality was 195 of 314 patients (62.1%) in the bicarbonate group and 193 of 313 (61.7%) in the control group (absolute difference, 0.4; 95% CI, −7.2 to 8.0; P = .91). There was no evidence of a group effect on day 28 or day 180 all-cause mortality. Among 18 secondary outcomes, kidney replacement therapy was used in 109 of 314 (35%) bicarbonate group patients and 157 of 313 (50%) controls (absolute difference, −15.5; 95% CI, −23.1 to −7.8). No evidence of a group effect was found on other secondary outcomes, including adverse events. Conclusions and Relevance For patients with severe metabolic acidemia and moderate to severe acute kidney injury, intravenous sodium bicarbonate did not affect mortality. Trial Registration ClinicalTrials.gov Identifier: NCT04010630

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Fichiers liés : 2025 Jung et al.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Jonas VanardoisPierre TrapPhilippe GoncalvesRoger FrançoisePierre LanariFrancesca PiccoliDidier MarquerJean-Louis PaquetteJérémie Melleton
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Université de Lausanne = University of Lausanne Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249) Géosciences Montpellier Université de Lausanne = University of Lausanne Universität Bern = University of Bern = Université de Berne Universität Bern = University of Bern = Université de Berne Laboratoire Magmas et Volcans Laboratoire Magmas et Volcans Bureau de Recherches Géologiques et Minières
• Publié dans Bulletin de la Société Géologique de France le 28/10/2020

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Résumé : This study investigates the P-T-t-D evolution of two metapelitic samples from the middle crust exposed in the Aiguilles Rouges Massif. Garnet compositional mapping, phase equilibrium modelling, zirconium-in-rutile thermometry, trace element geochemistry of garnet and monazite, and U-Pb LA-ICP-MS dating on monazite were used to better understand the tectonic and thermal history of the variscan External Crystalline Massifs. In the sample representing the upper-middle crust (AR736, southwestern part of the massif), using the preserved mineral assemblage in garnet inclusion

and garnet compositions, the prograde P-T path was constrained from ∼0.5-0.6 GPa and 550-625 °C to ∼0.76-0.82 GPa and 600-640 °C. The P-T conditions at the onset of this prograde evolution suggest a high geothermal gradient (∼30-35 °C/km) prior to the onset of crustal thickening. In the sample representing the lower-middle crust (AR14, central part of the massif), using the preserved mineral assemblage in garnet inclusion

, the occurrence of sillimanite and ilmenite in the matrix and garnet compositions, a b-shaped P-T path characterised by a late temperature increase during exhumation was identified. Both samples recorded a retrograde P-T stage at ∼0.4 GPa and 545 °C, dated at 315-305 Ma. Microstructural analysis indicates dextral transcurrent deformation from the late crustal thickening stage to the exhumation phase. Comparison with previously published P-T paths from eclogitic lenses highlights the juxtaposition of middle and lower crustal domains during dextral transcurrent deformation. We propose a tectonic model in which the formation of supra-subduction volcano-sedimentary basins (∼350 Ma) is followed by crustal thickening between 350 and 340 Ma under a thermal gradient of ∼5-15 °C/km. The exhumation of the lower and middle crust took place in a transcurrent regime between 340 and 305 Ma. This prolonged transcurrent tectonic activity suggests that the numerous transcurrent shear zones in the Variscan belt are not merely late orogenic structures but played a significant role in the geodynamic evolution, particularly in the exhumation of the orogenic crust, from the end of continental collision to the closure of the Variscan orogeny.

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Fichiers liés : bsgf230022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Nathalie DemaureJehanne Le CunffMaryline DuchêneBertrand RozecFabien EspitalierJean-Michel CabonJean-Ferréol OilleauPhilippe GuerciFrançois LabasteOsama Abou-ArabPierre-Grégoire GuinotPierre DuvalEmmanuel BesnierErwan FlécherIsabelle LeroyerJeff MorcetClaire Fougerou-LeurentAlexandre MansourNicolas Nesseler
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Service d'anesthésie et réanimation chirurgicale [Nantes] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Régional Universitaire de Tours CHRU Brest - Département d'Anesthésie Réanimation CHRU Brest - Département d'Anesthésie Réanimation Service d'Anesthésie et Réanimation [CHRU Nancy] Pôle Anesthésie Réanimation [CHU de Toulouse] Centre Hospitalier Universitaire d'Amiens-Picardie Université Marie et Louis Pasteur Service d'Anesthésie et Soins intensifs [CHU Rouen] Service d'Anesthésie et Soins intensifs [CHU Rouen] Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nutrition, Métabolismes et Cancer Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Nutrition, Métabolismes et Cancer
• Publié dans BMJ Open le 26/10/2020

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Résumé : Introduction Postoperative pulmonary complications (PPCs) are common after cardiac surgery and are associated with significant morbidity and mortality. Lung-protective ventilation strategies have been proposed to reduce PPCs, but the optimal level of positive end-expiratory pressure (PEEP) and the use of alveolar recruitment manoeuvres (RMs) remain controversial. Methods/analysis In this investigator-initiated, multicentre, open, randomised, parallel-group, superiority clinical trial, elective cardiac surgery patients at risk of PPCs will be assigned to one of two intraoperative ventilation strategies: (1) an open-lung ventilation strategy with protective ventilation, moderate PEEP and RMs or (2) a standard protective ventilation with low PEEP and no RM. The primary outcome will be a composite of prolonged (>24 hour) postoperative mechanical ventilation, reintubation for any cause or hospital-acquired pneumonia within 7 days of surgery, or death within 28 days of surgery. Data will be analysed on an intention-to-treat basis. Ethics and dissemination The VACARM (impact of intraoperatiVe moderAte positive end-expiratory pressure with reCruitment mAnoeuvres versus low positive end-expiRatory pressure on major postoperative pulMonary complications and death after on-pump cardiac surgery in high-risk patients) trial has been approved by an independent ethics committee for all study centres. Recruitment began in July 2021. Results will be published in international peer-reviewed medical journals. Trial registration number ClinicalTrials.gov NCT04408495 .

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Fichiers liés : e104179.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Iwona PrankeValeria CapurroBenoit ChevalierEmanuela PesceValeria TomatiCristina PastorinoMairead Kelly-AubertAurelie HattonElise DreanoMariateresa LenaRenata BocciardiFederico ZaraStefano PantanoVito TerlizziCristina LucantoStefano CostaLaura ClautValeria DaccòPiercarlo PoliMassimo MaschioBenedetta FabrizziNicole CaporelliMarco CipolliSonia VolpiFrederique ChedevergneLaure CossonJulie MaceySophie RamelLaurence WeissDominique GrenetLaurence Le Clainche-VialaBenoit DouvryBruno RavoninjatovoCamille AudoussetAurélie TatopoulosBénédicte Richaud-ThiriezMelissa BaravalleGuillaume ThouveninGuillaume LabbéMarie MittainePhilippe ReixIsabelle DurieuJulie MankikianStéphanie BuiThao Nguyen‐khoaKarim KhoukhClémence MartinJennifer da SilvaPaola de CarliCarlo CastellaniFederico CrestaLuis GaliettaAnne GuillemautEmmanuelle GirodonNatacha RemusMathis BulcaenMarjolein EnsinckMiroslaw ZajacMarianne CarlonJean LebihanPierre-Régis BurgelIsabelle Sermet-GaudelusAlexandre HinzpeterNicoletta Pedemonte
• Organismes : Research on Healthcare Performance
• Publié dans Frontiers in Pharmacology le 25/10/2020

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Résumé : Rationale Respiratory status of people with Cystic Fibrosis (pwCF) carrying N1303K is improved by Elexacaftor/Tezacaftor/Ivacaftor (ETI) but, contrary to other mutations, the impact on sweat test results is limited. Methods To explore this discrepancy, we implemented new sweat gland and respiratory cell lines stably expressing Wild type (WT)-, F508del- and N1303K-CFTR. CFTR dependent chloride (Cl − ) and bicarbonate (HCO 3 -) transport was measured by short circuit current in these new models and in primary Human Nasal Epithelial Cells (HNECs). CFTR expression was evaluated by Western blot. Results In the airway and the sweat gland cells expressing F508del-CFTR, ETI induced maturation of CFTR and increased Cl − transport. In the respiratory cell lines and HNECs, N1303K-CFTR generated both immature and mature forms of CFTR. Correction by ETI increased CFTR amounts without promoting its maturation and improved Cl − secretion. N1303K-CFTR channel activity was markedly increased by co-potentiation of IVA with Apigenin. In the sweat gland, N1303K-CFTR was expressed as a globally misfolded protein, non-rescuable by ETI. API treatment to 2 patients improved FEV1 without lowering sweat Cl- content. Conclusion N1303K-CFTR shows tissue specific correction and suboptimal response to ETI which can be improved by API.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 28/10/2025
• Auteurs : Hiba KhélifaNicolas IllyMarat MamurovVéronique BennevaultCécile HuinLachlan AlexanderJean-Michel GuignerJoshua D McgrawPhilippe GuéganKawthar Bouchemal
• Organismes : Institut de Recherche de Chimie Paris Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut de Recherche de Chimie Paris Monash University [Clayton] Muséum national d'Histoire naturelle Gulliver (UMR 7083) Institut Pierre-Gilles de Gennes pour la Microfluidique Institut Parisien de Chimie Moléculaire Institut de Recherche de Chimie Paris

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Résumé : The self-assembly of amphiphilic copolymers into well-defined nanoparticles depends on the interplay between polymer composition, solvent exchange kinetics, and processing conditions. In this study, we explore the anionic ring-opening copolymerization of 1,2-epoxybutane and ethoxyethyl glycidyl ether (EEGE) followed by a deprotection step to synthesize poly(butylene oxide)-stat-polyglycidol (PBO-stat-PG) copolymers with tunable amphiphilicity. Reactivity ratio analysis confirmed the formation of a gradient microstructure, with preferential incorporation of EEGE in the early polymerization stages. The copolymers were subsequently processed via bulk and microfluidic-assisted nanoprecipitation, and their self-assembly behavior was systematically investigated. Bulk nanoprecipitation demonstrated that the hydrophilic/hydrophobic balance plays a critical role in controlling nanoparticle formation, stability, and size distribution. Copolymers with 85/15 and 80/20 (BO/G) ratios exhibited the most favorable properties, leading to small, stable, and uniform nanoparticles, whereas excessive G content (≥70%) disrupted self-assembly, inducing irregular morphologies. To enhance nanoparticle homogeneity and minimize aggregation, hydrodynamic-flow-focusing (HFF) microfluidics with a fixed flow rate ratio and controlled mixing conditions were implemented. The highly reproducible microfluidic process enabled finer control over solvent exchange dynamics, leading to smaller and more monodisperse nanoparticles compared to bulk precipitation. The rapid solvent diffusion in the HFF system promoted fast nucleation, effectively reducing polydispersity and ensuring superior colloidal stability. This study establishes a direct correlation between copolymer composition, nanoprecipitation methods, and nanoparticle characteristics, providing a scalable and reproducible strategy for the design of well-defined amphiphilic nanostructures with a controlled hydrophilic/hydrophobic ratio. The optimized PBO-stat-PG nanoparticles present promising potential for biomedical applications, particularly in drug delivery, where controlled self-assembly and tailored hydrophilicity are crucial for performance.

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Fichiers liés : Khelifa et al nanoprecipitation - V2.pdf Khelifa et al nanoprecipitation - V2 (1).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/10/2025
• Auteurs : Sarah WilsonEmmanuelle LerayFloriane CalocerFabien RollotFauvernier, M.Laurent RemontetLudivine LaunaySandra VukusicEmmanuelle Le PageMarc DebouverieJonathan CironAurélie RuetJérôme de SèzeHélène ZéphirThibault MoreauDavid-Axel LaplaudChristine Lebrun-FrenayPierre ClavelouPierre M. LabaugeEric BergerJean PelletierOlivier HeinzlefEric ThouvenotJean-Philippe CamdessanchéCharlotte ArnaudNathalie DerachePierre BrangerLydia GuittetGilles-Louis DeferOlivier Dejardin
• Organismes : Université de Caen Normandie Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre d'Investigation Clinique [Rennes] Recherche en Pharmaco-épidémiologie et Recours aux Soins Département Méthodes quantitatives en santé publique École des Hautes Études en Santé Publique Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé Université de Caen Normandie - UFR Santé Université de Lyon Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Université Claude Bernard Lyon 1 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Service de Biostatistiques [Lyon] Département écologie évolutive [LBBE] Hospices Civils de Lyon Service de Biostatistiques [Lyon] Université de Caen Normandie Université de Lyon Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Nancy Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Département Neurologie [CHU Toulouse] Université Toulouse III Paul Sabatier - Faculté de médecine Purpan Institut Toulousain des Maladies Infectieuses et Inflammatoires Université de Bordeaux Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre d'Investigation Clinique [Bordeaux] Service de Neurologie [Strasbourg] CIC Strasbourg Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences Sclérose en Plaques - Lille Lille Neurosciences & Cognition - U 1172 Service de neurochirurgie [CHU Dijon] Centre d'épidémiologie des populations Hôpital Guillaume-et-René-Laennec [CHU Nantes] UR2CA - PIN - Douleur, Innovation & Neuromodulation Université de Nice Sophia-Antipolis Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Université de Montpellier CHU de Besançon, Service de neurologie Hôpital de la Timone [CHU - APHM] Pôle de Neurosciences Cliniques Centre Hospitalier Intercommunal de Poissy/Saint-Germain-en-Laye Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Université de Caen Normandie
• Publié dans BMC Neurology le 01/11/2020

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Résumé : Background: Access to healthcare and socioeconomic deprivation are intricately linked. No studies have been led to measure the effect of healthcare accessibility on mortality in patients with MS so far. The objective was to examine the influence of travel time to the expert MS centre and of the accessibility to primary healthcare services on excess mortality in MS. Methods: A retrospective observational cohort study recruited patients from 18 French MS expert centres, with an onset of MS between 1960 and 2015 and a follow-up of up to 30 years. Primary health facility accessibility was measured by the Spatial aCcessibility multiscAlar index. Specialist care accessibility was measured by road travel time to the expert MS centre. Excess death rates (EDR) and excess hazard ratios were studied using additive excess hazard models with multidimensional penalised splines. Results: The study included 33,697 patients. Patients with relapsing-onset MS (R-MS) with a travel time of 40 min had the lowest EDR (Men: 1.2 deaths per 100 person-years (95%CI [0.8;1.8]), women: 0.8 deaths per 100 person-years 95%CI[0.6;1.2]), lower than patients who lived further from the centre. No effect of primary care access was found for patients with R-MS, and no effect of accessibility to primary or specialised care was found for patients with primary progressive MS. Conclusion: This study reveals the impact of travel time to neurologists on excess mortality in patients with R-MS in France. This distance bias association highlights the importance of preventing a potential selection of patients followed in MS expert centres.

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Fichiers liés : s12883-025-04459-z.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/10/2025
• Auteurs : Eva Drevet MulardIliass ImamPierre-Damien CoureuxAnne BriolayLaurence BessueilleAntoine TarbyStéphane BalayssacSonoko NarisawaFélix LecornuVéronique GilardSébastien ViolotJosé Luis MillánGilles J. P. RautureauLionel BallutDavid Magne
• Organismes : Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques / Pathophysiology, Diagnosis and Treatments of Musculoskeletal Disorders Microbiologie moléculaire et biochimie structurale - Molecular Microbiology and Structural Biochemistry Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques / Pathophysiology, Diagnosis and Treatments of Musculoskeletal Disorders Microbiologie moléculaire et biochimie structurale - Molecular Microbiology and Structural Biochemistry Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Université Claude Bernard Lyon 1 Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques / Pathophysiology, Diagnosis and Treatments of Musculoskeletal Disorders Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Chimie des colloïdes, polymères & assemblages complexes Sanford Burnham Prebys Medical Discovery Institute Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques / Pathophysiology, Diagnosis and Treatments of Musculoskeletal Disorders Chimie des colloïdes, polymères & assemblages complexes Université Claude Bernard Lyon 1 Microbiologie moléculaire et biochimie structurale - Molecular Microbiology and Structural Biochemistry Sanford Burnham Prebys Medical Discovery Institute Université Claude Bernard Lyon 1 Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques / Pathophysiology, Diagnosis and Treatments of Musculoskeletal Disorders Microbiologie moléculaire et biochimie structurale - Molecular Microbiology and Structural Biochemistry Université Claude Bernard Lyon 1 Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques / Pathophysiology, Diagnosis and Treatments of Musculoskeletal Disorders
• Publié dans Communications Biology le 26/10/2020

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Résumé : Tissue-nonspecific alkaline phosphatase (TNAP) is primarily known for its role in skeletal mineralization, through the hydrolysis of inorganic pyrophosphate (PPi). Here we demonstrate that TNAP-knockout mice exhibit liver steatosis and reduced serum triglyceride levels, mirroring the effects of choline deficiency, which impairs phosphatidylcholine synthesis, an essential component of VLDL. In fasting WT mice, TNAP inhibition via SBI-425 administration decreases choline levels in blood and liver. Incubating mouse or human serum with SBI-425 inhibits the dephosphorylation of phosphocholine and phosphoethanolamine, an alternative substrate for hepatic phosphatidylcholine synthesis. In hepatocytes, TNAP inhibition impedes proliferation when the medium is supplemented with phosphocholine instead of choline. Recombinant TNAP hydrolyzes phosphocholine and phosphoethanolamine with similar efficiency than PPi. X-ray diffraction and cryo-EM identified the residues in TNAP's active site interacting with phosphocholine, PPi and the TNAP inhibitor. In summary, TNAP is the phosphatase enabling cellular choline uptake during fasting, participating in hepatic lipid metabolism.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/10/2025
• Auteurs : Fraysse ClémentR. DelunelPhilippe SorrelGilles DromartOdile FrancHélène TissouxPierre VallaPierre VoinchetJean-François BuoncristianiYanni Gunnell
• Organismes : Environnement, Ville, Société Environnement, Ville, Société Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Institut national de recherches archéologiques préventives Bureau de Recherches Géologiques et Minières Histoire naturelle de l'Homme préhistorique Institut des Sciences de la Terre Histoire naturelle de l'Homme préhistorique Biogéosciences [UMR 6282] Environnement, Ville, Société

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Résumé : A la transition plio-pléistocène, une augmentation significative des apports sédimentaires détritiques est enregistrée dans le bassin d’avant-pays des Alpes occidentales, générant des topographies d’accumulation aujourd’hui en inversion de relief. Ces formations témoignent de la première structuration du réseau hydrographique Rhône-Isère et des dynamiques sédimentaires associées. Au cours du Pléistocène, ce piémont a également enregistré les incursions et retraits cycliques des glaciers alpins, ces derniers ayant fortement influencé la morphogenèse régionale. La Côtière de la Dombes, escarpement méridional du plateau de la Dombes situé au nord-est de Lyon, illustre une évolution des environnements de dépôt marquée par le fonctionnement du cône alluvial villafranchien du Rhône, puis par le remaniement de ces dépôts par les incur- sions glaciaires pléistocènes. Cette dynamique se traduit par une juxtaposition et imbrication de dépôts alluviaux, glaciaires, fluvio-glaciaires, fluvio-lacustres et deltaïques témoignant du remplissage d’un système de paléovallées. Pour mieux comprendre l’évolution géomorphologique de la Dombes, nous présentons ici une étude sédimentologique de terrain visant à harmoniser la classification des faciès exposés dans la Côtière, et proposons des contraintes géochronologiques des principales formations via les nucléides cosmogéniques produits in situ (TCN ; couple 26Al/10Be), la résonance de spin électronique (ESR), et la luminescence stimulée optiquement (OSL). Les premières données obtenues permettent de dater le maximum d’extension glaciaire (MEG) par un scénario complexe d’exposition d’un dépôt morainique à Mionnay, à l’ouest du marais des Échets. Deux âges OSL à 36 et 100 ka ont été obtenus pour les lœss recouvrant la moraine et atténuant ainsi la production de TCN. Une approche de modélisation (profil en profondeur) suggère un âge d’environ 250 ka (Riss, MIS8) pour le dépôt de la moraine. Enfin, les con- centrations TCN acquises le long d’un profil vertical pour les alluvions villafranchiennes (Alluvions jaunes, localement) semblent saturées, ne permettant pour lors que de d’estimer le taux d’érosion de la formation depuis son dépôt. Des échantillons TCN et ESR qui sont en attente de mesure permettront de contraindre la mise en place de cette formation d’ampleur régionale, `a l’échelle du piedmont des Alpes occidentales.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/10/2025
• Auteurs : Lucas KhellafRaphaele SerorCaterina RicordiStephanie ChhunAudes GleizesHervé LobbesClara PouchelonMarie Charlotte BesseJean-Emmanuel KahnSabine RevuzMarina CuminDimitri Titeca-BeauportMatthias PapoPhilippe RémyMarie DespretsFlorian GaroCharles RonsinSalima Hacein-Bey-AbinaAmélie ServettazPatrice CacoubXavier PuéchalBenjamin Terrier
• Organismes : Assistance publique - Hôpitaux de Paris Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes AUSL di Reggio Emilia Istituto di Ricerca a Carattere Clinico Scientifico [Reggio Emilia, Italie] Assistance publique - Hôpitaux de Paris Assistance publique - Hôpitaux de Paris Service Médecine Interne - site Estaing [CHU Clermont-Ferrand] Assistance publique - Hôpitaux de Paris Centre Hospitalier Régional Universitaire de Tours AP-HP - Hôpital Ambroise Paré CHU Sud Saint Pierre [Ile de la Réunion] Centre Hospitalier Libourne Centre Hospitalier Universitaire d'Amiens-Picardie Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 Assistance publique - Hôpitaux de Paris Assistance publique - Hôpitaux de Paris Centre Hospitalier de Cholet Centre Hospitalier Universitaire de Nîmes Assistance publique - Hôpitaux de Paris Laboratoire d'Hématologie [CHU Nantes] AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital Cochin - Port-Royal AP-HP - Hôpital Cochin

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