Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 28/07/2025
• Auteurs : Jean-Philippe ChippauxPierre AmtaYoann MadecRodrigue NtoneGaelle NoelPedro ClauteauxYap Boum IiArmand S NkwescheuFabien Taieb
• Organismes : Institut de Recherche pour le Développement Hôpital de Tokombéré [Tokombéré, Cameroon] Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology Epicentre [Paris] [Médecins Sans Frontières] Centre de Recherche Translationnelle - Center for Translational Science Centre de Recherche Translationnelle - Center for Translational Science Institut Pasteur de Bangui Cameroon Society of Epidemiology [Yaounde] Centre Médical de l'Institut Pasteur
• Publié dans PLoS Neglected Tropical Diseases le 23/10/2020

---

Résumé : Background Species of the genus Echis , particularly those of the ‘ ocellatus ’ group, are responsible for the majority of snakebite envenomations and deaths in the savannas of sub-Saharan Africa. In a clinical study conducted in Cameroon, we treated a series of patients bitten by formally identified E. romani . The clinical outcomes are described and discussed. Methodology/Principal findings Specimens brought in by the victim were identified by a herpetologist. Clinical description and therapeutic management followed a standardized protocol applied by trained physicians. We included 92 patients, 95% of whom (n = 87) were envenomated. More than one third of the bites occurred during agricultural work, and one quarter in the victim’s home. The bite site was the foot in 48 victims (52%) and the hand in 40 others (43%), mostly children and teenagers. Cytotoxic syndrome was observed in 84 of the 87 envenomated patients (97%). Hemostasis disorders were observed in 78 patients (90%), 38 of whom (44%) experienced bleeding during hospitalization. In 5 of the latter (13%), the bleeding recurred, whereas it had stopped after antivenom administration. A further 7 patients, who were not bleeding on arrival, experienced late bleeding despite antivenom administration. Four patients (4.3%), including one pregnant woman, died. All were bleeding on arrival. Finally, 2 patients (2.2%) had permanent sequelae of moderate severity. Conclusion/Significance This study confirms the frequency and severity of hemorrhagic complications in E. romani envenomation. Lethality remains high despite antivenom treatment. Cytotoxic syndromes, present in 95% of victims, rarely progress to extensive necrosis.

---

Fichiers liés : Epidemiologic, clinical, and therapeutic_journal.pntd.0013195.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 25/07/2025
• Auteurs : Marco ScardiaJean-Louis PrieurJean-Pierre RivetDavid VernetEric AristidiJosefina F LingLuca PiccottiLuigi PansecchiRobert W. ArgyleLyu AbePhilippe BendjoyaLuca Maccarini
• Organismes : INAF - Osservatorio Astronomico di Brera Institut de recherche en astrophysique et planétologie Joseph Louis LAGRANGE Observatoire de la Côte d'Azur Joseph Louis LAGRANGE Universidade de Santiago de Compostela [España] = University of Santiago de Compostela [Spain] = Université de Saint-Jacques-de-Compostelle [Espagne] Universidade de Santiago de Compostela [España] = University of Santiago de Compostela [Spain] = Université de Saint-Jacques-de-Compostelle [Espagne] INAF - Osservatorio Astronomico di Brera Institute of Astronomy [Cambridge]
• Publié dans Astronomical Notes / Astronomische Nachrichten le 27/10/2020

---

Résumé : We present relative astrometric measurements of visual double stars, made in 2017-2018 with the speckle camera PISCO at the 1-m Epsilon telescope of the C2PU facility (Observatoire de la Côte d’Azur, Calern site). Our observing list contains orbital couples as well as double stars whose motion is still uncertain. From our observations of 1400 multiple stars, we obtained 1376 new measurements with angular separations in the range 0′′ .1 — 8′′ .5, and an average accuracy of 0′′ .008. The mean error on the position angles is 0◦ .50. Most of the position angles were determined without the usual 180◦ ambiguity with the application of the direct vector auto-correlation technique and/or by inspection of the long integration files. We present new and revised orbits for A1913 AB, A1710, COU1394, BU1185, A122, A570, HU577, COU812, HU332, A2095 AB, and A884, partly derived from our PISCO observations. The corresponding estimated values for the masses of those systems are compatible with the spectral types.

---

Fichiers liés : doc.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 25/07/2025
• Auteurs : Luisa RubinoPeter AbrahamianWenxia AnMiguel ArandaJosé T Ascencio-IbañezNicolas BejermanArnaud G BlouinThierry CandresseTomas CantoMengji CaoJohn P CarrWon Kyong ChoFiona ConstableIndranil DasguptaHumberto DebatRalf G DietzgenMichele DigiaroLivia DonaireToufic ElbeainoDenis FargetteFiona FilardoMatthias G FischerNuria FontdevilaAdrian FoxJuliana Freitas-AstuaMarc FuchsAndrew D.W. GeeringMahan GhafariAnders HafrénJohn HammondRosemarie HammondBeata Hasiów-JaroszewskaEugénie HébrardCarmen HernándezJean-Michel HilyAhmed HosseiniRoger HullAlice K Inoue-NagataRamon JordanHideki KondoJan F KreuzeMart KrupovicKenji KubotaJens H KuhnScott LeisnerJean-Michel LettChengyu LiFan LiJun Min LiPaola López-LambertiniJuan Lopez-MoyaFrançois MaclotKristiina MäkinenDarren MartinSébastien MassartW Allen MillerMusa MohammadiDimitre MollovEmmanuelle MullerTatsuya NagataJesús Navas-CastilloYutaro NeriyaFrancisco Ochoa-CoronaKazusato OhshimaVicente PallásHanu PappuKarel PetrzikMikhail M. PoogginMaria Isabella PrigigalloPedro Ramos-GonzálezSimone RibeiroKatja Richert-PöggelerPhilippe RoumagnacAvijit RoySead SabanadzovicDana ŠafářováPasquale SaldarelliHélène SanfaçonCecilia SarmientoTakahide SasayaKay ScheetsWillem E W SchravesandeSusan SealYoshifumi ShimomotoMerike SõmeraLivia StavoloneLucy R StewartPierre-Yves TeycheneyJohn E ThomasJeremy R ThompsonAntonio TiberiniYasuhiro TomitakaIoannis TzanetakisMarie UmberCica UrbinoHarrold A van den BurgRené A.A. van der VlugtArvind VarsaniAdriaan VerhageDan VillamorSusanne von BargenPeter J WalkerThierry WetzelAnna E WhitfieldStephen J WylieCaixia YangF Murilo ZerbiniSong ZhangIctv Taxonomy Summary ConsortiumEvelien AdriaenssensPoliane Alfenas-ZerbiniFrank O AylwardR. Curtis HendricksonHolly HughesElliot J LefkowitzMałgorzata ŁobockaRichard MayneArcady MushegianHanna M. OksanenJudit J. PénzesAlejandro Reyes MuñozDavid L RobertsonSimon RouxPeter SimmondsDonald B SmithNobuhiro SuzukiDann TurnerKoenraad van Doorslaer
• Organismes : CNR Istituto per la Protezione Sostenibile delle Piante [Torino, Italia] USDA-ARS : Agricultural Research Service Shenyang Ligong University Centro de Edafologia y Biologia aplicada del Segura North Carolina State University [Raleigh] Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] Agroscope Biologie du fruit et pathologie Centro de Investigaciones Biológicas Margarita Salas Southwest University [Chongqing] University of Cambridge [Cambridge, UK] Kangwon National University La Trobe University [Melbourne] University of Delhi South Campus [New Delhi] Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] Queensland Alliance for Agriculture and Food Innovation Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Bari Centro de Edafologia y Biologia aplicada del Segura Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Bari Virus South Data Queensland Department of Primary Industries Max Planck Institute for Marine Microbiology Agroscope Fera Science Ltd Brazilian Agricultural Research Corporation = Empresa Brasileira de Pesquisa Agropecuária Cornell University [Ithaca, NY, USA] Queensland Alliance for Agriculture and Food Innovation University of Oxford Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet USDA-ARS : Agricultural Research Service USDA-ARS : Agricultural Research Service Molecular Plant Pathology Laboratory Institute of Plant Protection-National Research Institute Plant Health Institute of Montpellier Instituto de Biologia Molecular y Celular de Plantas Institut Français de la Vigne et du Vin [Siège] Vali-e-Aser University of Rafsanjan Retired John Innes Centre [Norwich] Brazilian Agricultural Research Corporation = Empresa Brasileira de Pesquisa Agropecuária Embrapa Hortaliças USDA-ARS : Agricultural Research Service Okayama University Institute of Plant Science and Resources International Potato Center [Lima] Virologie des archées - Archaeal Virology 農業・食品産業技術総合研究機構 - National Agriculture and Food Research Organization [Tsukuba, Japan] Integrated Research Facility at Fort Detrick University of Toledo Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Shenyang Ligong University Yunnan Agricultural University State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Ningbo University Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] Centre for Research in Agricultural Genomics Biologie du fruit et pathologie Helsingin yliopisto = Helsingfors universitet = University of Helsinki Institute of Infectious Disease and Molecular Medicine Unité de recherche TERRA [Gembloux] Iowa State University Gorgan University of Agriculture and Natural Resources USDA Animal and Plant Health Inspection Service Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Universidade de Brasilia = University of Brasilia [Brasília] Instituto de Hortofruticultura Subtropical y Mediterranea "La Mayora" Utsunomiya University [Utsunomiya] Oklahoma State University [Stillwater] Saga University [Japon] Instituto de Biologia Molecular y Celular de Plantas Washington State University Institute of Plant Molecular Biology [Branišovská] Plant Health Institute of Montpellier CNR Istituto per la Protezione Sostenibile delle Piante [Torino, Italia] Universidade de São Paulo = University of São Paulo Embrapa Recursos Genéticos e Biotecnologia = Embrapa Genetic Resources & Biotechnology Julius Kühn-Institut - Federal Research Centre for Cultivated Plants Institute for Epidemiology and Pathogen Diagnostics Plant Health Institute of Montpellier USDA-ARS : Agricultural Research Service Mississippi State University [Mississippi] Palacky University Olomouc CNR Istituto per la Protezione Sostenibile delle Piante [Torino, Italia] Agriculture and Agri-Food Canada Summerland Research and Development Centre Tallinn University of Technology 農業・食品産業技術総合研究機構 - National Agriculture and Food Research Organization [Tsukuba, Japan] Oklahoma State University [Stillwater] Universiteit van Amsterdam = University of Amsterdam University of Greenwich Kochi Agricultural Research Center Tallinn University of Technology CNR Istituto per la Protezione Sostenibile delle Piante [Torino, Italia] Unaffiliated Researcher Peuplements végétaux et bioagresseurs en milieu tropical Queensland Alliance for Agriculture and Food Innovation Plant Health and Environment Laboratory, Ministry for Primary Industries Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics 農業・食品産業技術総合研究機構 - National Agriculture and Food Research Organization [Tsukuba, Japan] University of Arkansas [Fayetteville] Agrosystèmes tropicaux Plant Health Institute of Montpellier Universiteit van Amsterdam = University of Amsterdam Wageningen University and Research [Wageningen] Arizona State University [Tempe] Rijk Zwaan Breeding BV, University of Arkansas [Fayetteville] Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Albrecht Daniel Thaer - Institute of Agricultural and Horticultural Sciences The University of Queensland Dienstleistungszentrum Ländlicher Raum DLR Rheinpfalz North Carolina State University [Raleigh] Murdoch University [Perth] Shenyang Ligong University Universidade Federal de Viçosa [Brasil] = Federal University of Viçosa [Brazil] = Université fédérale de Viçosa [Brésil] Southwest University [Chongqing] Quadram Institute Bioscience [Norwich, U.K.] Universidade Federal de Viçosa [Brasil] = Federal University of Viçosa [Brazil] = Université fédérale de Viçosa [Brésil] Virginia Tech [Blacksburg] Centers for Disease Control and Prevention [Fort Collins, Co., USA] Centers for Disease Control and Prevention [Fort Collins, Co., USA] University of Alabama [Birmingham] Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences University of the West of England [Bristol] National Science Foundation [Arlington] Helsingin yliopisto = Helsingfors universitet = University of Helsinki Institute for Veterinary Medical Research [Budapest] Armand-Frappier Santé Biotechnologie Research Centre Faculty of Biological and Environmental Sciences [Helsinki] University of Glasgow Lawrence Berkeley National Laboratory [Berkeley] University of Oxford University of Oxford Okayama University University of the West of England [Bristol] University of Arizona
• Publié dans Journal of General Virology le 01/11/2020

---

Résumé : In March 2025, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote, newly proposed taxa were added to those under the mandate of the Plant Viruses Subcommittee. In brief, 1 new order, 3 new families, 6 new genera, 2 new subgenera and 206 new species were created. Some taxa were reorganized. Genus Cytorhabdovirus in the family Rhabdoviridae was abolished and its taxa were redistributed into three new genera Alphacytorhabdovirus , Betacytorhabdovirus and Gammacytorhabdovirus . Genus Waikavirus in the family Secoviridae was reorganized into two subgenera ( Actinidivirus and Ritunrivirus ). One family and four previously unaffiliated genera were moved to the newly established order Tombendovirales . Twelve species not assigned to a genus were abolished. To comply with the ICTV mandate of a binomial format for virus species, eight species were renamed. Demarcation criteria in the absence of biological information were defined in the genus Ilarvirus (family Bromoviridae ). This article presents the updated taxonomy put forth by the Plant Viruses Subcommittee and ratified by the ICTV.

---

Fichiers liés : jgv002114 (1).pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 24/07/2025
• Auteurs : Delphine BonhommeHugo VayssetEirene Marie Q. EdnacotVasco RodriguesYazan SalloumJean CuryAnny WangAxel BenchetritPierre AffaticatiVeronica Hernandez-TrejoPaul VittotCharlie BoriesAlexis CornecJean-Pierre LevraudPedro P HernándezPhilippe BenarochBenjamin MorehouseAude BernheimEnzo Z Poirier
• Organismes : Immunité et cancer Diversité moléculaire des microbes / Molecular diversity of microbes AgroParisTech University of California [Irvine] Immunité et cancer Génétique et Biologie du Développement Diversité moléculaire des microbes / Molecular diversity of microbes University of California [Irvine] Transgénèse pour les Etudes Fonctionnelles sur les Organismes Modèles Transgénèse pour les Etudes Fonctionnelles sur les Organismes Modèles Immunité et cancer Immunité et cancer Immunité et cancer Immunité et cancer Transgénèse pour les Etudes Fonctionnelles sur les Organismes Modèles NeuroInfection et Immunité - NeuroInfection and Immunity Génétique et Biologie du Développement Immunité et cancer University of California [Irvine] Diversité moléculaire des microbes / Molecular diversity of microbes Immunité et cancer
• Publié dans Science le 22/10/2020

---

Résumé : Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent information regulator 2 (SIR2) protein domain, present in antiphage systems, plays a role in eukaryotic innate immunity. We identified SIRal, a human protein with a SIRim domain (subtype of SIR2) that plays a pivotal role in the animal Toll-like receptor pathway of innate immunity and protects against bacterial and viral infections. Proteins containing a SIRim domain are found across 19% of eukaryotic genomes, including zebrafish, where SIRal plays a role in inflammation. This work opens up avenues of research on the immune role of eukaryotic SIRim proteins as well as on the involvement of SIRal in human pathology.

---

Fichiers liés : adr8536_CombinedPDF_v3-2.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 23/07/2025
• Auteurs : Jean-Charles PicaudOlivier ClarisMercedes Gil-CamposIgnacio Salamanca de la CuevaLuc CornettePhilippe AllietAndré LekeMireille CastanetHugues PiloquetVirginie de HalleuxDelphine MitanchezYvan VandenplasPierre MatonFrank JochumDirk OlbertzSergio Negre PolicarpoLuca LavalleCecilia FumeroPaula Rodriguez-GarciaJanne Marie MollIrma Silva-ZolezziBoutaina ZemraniNicholas HaysNorbert SprengerJavier Miranda-Mallea
• Organismes : Hôpital de la Croix-Rousse [CHU - HCL] Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Université Claude Bernard Lyon 1 Instituto Maimonides de Investigación Biomédica de Cordoba Instituto Hispalense de Pediatria [Sevilla, Spain] Sint-Jan General Hospital Jessa Ziekenhuis = Jessa Hospital Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Neuroendocrine, Endocrine and Germinal Differentiation Communication Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Physiopathologie des Adaptations Nutritionnelles Centre Hospitalier Universitaire de Liège Centre Hospitalier Régional Universitaire de Tours Vrije Universiteit Brussel [Bruxelles] Clinique CHC MontLégia [Liège, Belgium] Evangelisches Waldkrankenhaus Spandau University of Rostock = Universität Rostock Hospital Quirónsalud Bizkaia [Bilbao] Nestlé Research Center | Centre de recherche Nestlé [Lausanne] Nestlé Research Center | Centre de recherche Nestlé [Lausanne] Copenhagen University, Copenhagen, Denmark. Copenhagen University, Copenhagen, Denmark. Nestlé Product Technology Center Dairy Nestlé Institute of Health Sciences SA [Lausanne, Switzerland] Nestlé Product Technology Center Dairy Nestlé Research Center | Centre de recherche Nestlé [Lausanne] Hospital Vithas Vitoria = Vithas Vitoria Hospital
• Publié dans Frontiers in Nutrition le 25/10/2020

---

Résumé : Gut health and microbiome development are closely linked in early life, with human milk oligosaccharides (HMOs) playing a key role. This study reports results through 4 months of age from a trial evaluating an infant formula containing a synbiotic blend of HMOs and probiotics, focusing on growth, gastrointestinal (GI) tolerance, and gut health biomarkers from birth to 15 months. Materials and methods Healthy infants aged ≤14 days were randomized to receive either the experimental formula (SYN; control formula supplemented with six HMOs and two probiotics [ B. infantis , B. lactis ]) or the control formula (CTRL; partially hydrolyzed 100% whey-based formula). A non-randomized breastfed (BF) group served as a reference. The primary endpoint was weight gain velocity in SYN vs. CTRL through 4 months of age. Secondary endpoints included fecal outcomes (abundance of bifidobacteria, immune and gut health markers), GI tolerance, and adverse events (AEs). Results The full analysis set (FAS) included 313 infants (118 in SYN, 114 in CTRL, and 81 BF), while the per-protocol population (PP) included 227 infants (84 in SYN, 84 in CTRL, and 59 BF). Weight gain velocity through 4 months in the SYN group was non-inferior to that in the CTRL group in both FAS and PP analyses (both p < 0.0001). Parent-reported GI tolerance and stool patterns were similar between SYN and CTRL groups through 4 months. At 3 months, Bifidobacteria abundance was significantly higher in the SYN group compared to the CTRL group ( p = 0.004). Fecal pH was lower in the SYN group than in the CTRL group ( p = 0.018) and more closely resembled that of the BF group. Immune and gut health markers were similar between the SYN and BF groups. No significant differences in AEs were observed across groups. Conclusion The synbiotic-supplemented infant formula supported healthy, age-appropriate growth, good GI tolerance, and increased the abundance of beneficial bifidobacteria through4 months of age.

---

Fichiers liés : 2025_Picaud_Front_Nutrition.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 22/07/2025
• Auteurs : Juliette QuintinAurélie Le ThuautFabienne PlouvierYoann ZerbibMichel SirodotNicholas SedillotKahaia de LongeauxAnthony Le MeurBertrand SouweineJean-Pierre QuenotJean-Claude LacheradeJulie NoublancheMickael LandaisDidier TheveninSaad NseirThomas LafonThierry VanderlindenRoland SmonigLaurent ArgaudLouis ChauvelotMarlène DuboisR. LarcherFlorian BerteauJean DellamonicaSaber Davide BarbarMathieu SerieToufik KamelFrederic JacobsNicolas de ProstJérôme DevaquetNicholas HemingMarc Pineton de ChambrunPhilippe MichelMichel DjibréAlexis FerreWalter PicardKieran PinceauxFabienne TamionFrancois LegayMaud JonasAnais CurtiaudStephan EhrmannJulien HuntzingerChristophe CraccoFrédérique SchortgenPhilippe LetocartJean Reignier
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Agen-Nérac Médecine Intensive-Réanimation [CHU Amiens] UFR de Médecine - Université de Picardie Jules Verne Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Centre Hospitalier Fleyriat [Bourg en Bresse] Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier de Cholet CHU Clermont-Ferrand Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier de Lens Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Experience ; Technology & Human Interactions ; Care & Society : Groupement des Hôpitaux de l'Institut Catholique de Lille Centre Hospitalier de Lorient Hôpital Edouard Herriot [CHU - HCL] Hospices Civils de Lyon Hôpital de la Croix-Rousse [CHU - HCL] Hospices Civils de Lyon Centre hospitalier de Montauban Centre Hospitalier Régional Universitaire [Montpellier] CH Morlaix Centre Hospitalier Universitaire de Nice Unité de Recherche Clinique Côte d’Azur Centre Hospitalier Universitaire de Nîmes Centre hospitalier territorial Gaston-Bourret [Dumbea, Nouvelle-Calédonie] Centre Hospitalier Universitaire d'Orléans AP-HP - Hôpital Antoine Béclère [Clamart] Hôpital Henri Mondor Hôpital Foch [Suresnes] Hôpital Raymond Poincaré [AP-HP] Université de Versailles Saint-Quentin-en-Yvelines CHU Pitié-Salpêtrière [AP-HP] Hôpital NOVO CHU Tenon [AP-HP] Centre Hospitalier de Versailles André Mignot CHU de Pau Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] CHU Rouen Hôpital de Saint-Brieuc [Hôpital Yves Le Foll] Centre hospitalier de Saint-Nazaire Hôpitaux Universitaires de Strasbourg Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Régional Universitaire de Tours Centre hospitalier Bretagne Atlantique (Morbihan) Centre Hospitalier d'Angoulême Centre Hospitalier Intercommunal de Créteil Centre hospitalier de Rodez Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Hôpital Hôtel-Dieu [CHU Nantes]
• Publié dans Critical Care le 31/10/2020

---

Résumé : Background Millions of households have cats or dogs as pets, and infections due to bites or scratches are increasing, with the most common pathogens being Pasteurella spp., Bartonella spp., Capnocytophaga spp, and Francisella tularensis. The objective of this study was to describe patients admitted to the intensive care unit (ICU) for infection transmitted by cats or dogs, as well as their outcomes. Methods The retrospective multicentre observational cohort study PETSEPSIS included consecutive adults admitted to 46 ICUs in France between 2009 and 2019 for sepsis due to cat or dog bites and/or caused by any of the four above-listed bacteria. We described their features and outcomes and performed univariate and multivariate analyses to identify factors associated with death. Results We included 174 patients with a median age of 64 [50–74] years; 58.1% were male. The median SAPS II score was 42 [28–58]. Mechanical ventilation was required in 51.2% of patients, for a median duration of 7 [4–13] days. Vasopressor support was used in 53.5%, renal replacement therapy in 19%, and limb amputation in 3.6% of the patients. The median ICU length of stay was 7 [4–16] days. Hospital mortality was 24.1%. The clinical presentation and severity of sepsis were similar across bacteria, although patients with Pasteurella spp. were older and had more comorbidities. Contact with cats were more often reported for Pasteurella spp. and Bartonella spp. infections and contact with dogs for Capnocytophaga spp. infections. Risk factors for hospital mortality present on ICU admission were older age, smoking, preexisting liver disease, high serum creatinine, and anaemia. Neither the type of micro-organism nor the initial antimicrobial treatment was associated with mortality. Conclusions This large multicentre study shows that infections transmitted by cats and dogs are infrequent reasons for ICU admission but are associated with substantial morbidity and mortality. Mortality was associated with older age and comorbidities but not with the type of microorganism or initial antibiotic treatment.

---

Fichiers liés : s13054-025-05558-6-2.pdf

---

Source

---

• Type de publi. :
• Date de publi. : 20/07/2025
• Auteurs : Jean-Philippe SarretteAndré RicardJ P GardouF. Marchal
• Organismes : Plasmas Réactifs Hors Equilibre LAboratoire PLasma et Conversion d'Energie Plasmas Réactifs Hors Equilibre

---

Résumé :

---

Fichiers liés : Sarrette et al_ICPIG2025.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 18/07/2025
• Auteurs : Aude VialatteAnaïs TibiAudrey AlignierValérie AngeonLaurent BedoussacDavid A BohanDouadia BougheraraCordeau, S.Pierre CourtoisJean-Philippe DeguineJérôme EnjalbertFrédéric FabreHélène FrévilleBenoît GrimonprezNicolas GrossMourad HannachiMarie LaunayStéphane LemariéGilles MartelMireille NavarreteManuel PlantegenestVirginie RavignéAdrien RuschFrédéric SuffertSophie ThoyerVincent Martinet
• Organismes : Dynamiques et écologie des paysages agriforestiers Direction de l'Expertise scientifique collective, de la Prospective et des Etudes Biodiversité agroécologie et aménagement du paysage Ecodéveloppement AGroécologie, Innovations, teRritoires Agroécologie [Dijon] Centre d'Economie de l'Environnement - Montpellier Agroécologie [Dijon] Centre d'Economie de l'Environnement - Montpellier Plant Health Institute of Montpellier Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Santé et agroécologie du vignoble Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Centre d’études et de coopération juridique interdisciplinaire – Université de Poitiers [UR 20418] Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR Sciences pour l'Action et le Développement : Activités, Produits, Territoires Agroclim Laboratoire d'Economie Appliquée de Grenoble Biodiversité agroécologie et aménagement du paysage Ecodéveloppement Institut de Génétique, Environnement et Protection des Plantes Peuplements végétaux et bioagresseurs en milieu tropical Santé et agroécologie du vignoble BIOlogie et GEstion des Risques en agriculture Centre d'Economie de l'Environnement - Montpellier Paris-Saclay Applied Economics
• Publié dans One Earth le 13/11/2020

---

Résumé : Plant diversification at field, farm, and landscape scales is a key strategy for protecting crops from pests. But its level of adoption remains confidential, while the overall negative impacts of pesticides are now well established. To understand the obstacles to this adoption, we conducted an extensive review of literature in life and socio-economic sciences. We found that all diversification practices are largely effective in pest control, achieving satisfactory yields and many ecological cobenefits, although context dependent. Plant diversification does not appear solely as an alternative to pesticide-based pest control but as a transformative approach to achieve sustainable agrifood systems. However, its adoption is currently strongly hindered by socioeconomic barriers, including low short-term profitability, rigid agricultural sectors, and limited support from public policies. The most beneficial practices, agroforestry and diversified landscapes, face the greatest obstacles. In contrast, cultivar mixtures, while easier to implement, offer limited cobenefits. Collaboration between scientists, policymakers, and local stakeholders seems essential to scale up plant diversification.

---

Fichiers liés : Vialatte et al. 2025 One Earth.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2025
• Auteurs : Julien VaidieJulien DemiselleAnthony GabrielAntoine GuillonEdwige PéjuFrédéric PènePiotr SzychowiakBoris DelangePauline GuillotJean-Claude LacheradePierre AsfarAnn ZaluckyPhilippe VignonBruno EvrardBruno François
• Organismes : Centre Hospitalier Universitaire Dupuytren 1 et 2 Nanomédecine Régénérative Centre de Recherche en Biomédecine de Strasbourg Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre Hospitalier Régional Universitaire de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Hôpital Cochin [AP-HP] Centre Hospitalier Régional d'Orléans Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Départemental Vendée Centre Hospitalier Universitaire d'Angers University of Calgary Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
• Publié dans Intensive Care Medicine le 27/10/2020

---

Résumé : Purpose: Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of immunosuppressive drugs > 24h) on day-90 mortality and ICU-acquired infections. Methods: This multicenter observational retrospective study conducted in solid organ transplant patients admitted to nine ICUs used a Bayesian approach with priors based on a belief elicitation process conducted among a panel of experts. Results: Among 591 enrolled patients, suspension strategy was used in 34% of them, during a median period of 5 days [IQR: 3-10]. This approach was more common in patients admitted for sepsis (38%) or COVID-19 (49%) than for non-septic causes (24%) (p < 0.001). Overall, day-90 mortality reached 30%, and Bayesian analysis revealed substantial uncertainty with an OR at 1.13 (95% Credible Interval (CrI): 0.74-1.70), and a 15% probability of a beneficial effect. In the subgroup of patients with sepsis, OR was at 0.90 (95% CrI: 0.55-1.55), with a 50% probability of a beneficial effect. ICU-acquired infections occurred in 26% of patients. The suspension strategy indicated a potential benefit, both in the entire cohort, with a 73% probability of a beneficial effect [OR: 0.74 (95% CrI: 0.49-1.15)], and in the subgroup of sepsis patients with a 78% probability of beneficial effect [OR 0.70 (95% CrI, 0.42-1.16)]. Conclusion: Temporary suspension of immunosuppressive drugs may reduce the risk of ICU-acquired infections, with a true uncertainty on day-90 mortality. Prospective studies are warranted to confirm these results.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2025
• Auteurs : Pierre BayÉtienne AudureauSlim FouratiNicolas de ProstSébastien PréauRaphaël FavoryAurélie GuigonNicholas HemingElyanne GaultTài PhamAmal ChaghouriMatthieu TurpinLaurence Morand-JoubertSébastien JochmansAurélia PitschSylvie MeirelesDamien ContouAmandine HenryAdrien JosephMarie-Laure ChaixFabrice UhelDamien RouxDelphyne DescampsMalo EmeryClaudio Garcia-SanchezDavid LevySonia BurrelJulien MayauxAntoine KimmounCédric HartardFrédéric PèneFlore RozenbergStéphane GaudrySégolène BrichlerAntoine GuillonLynda HandalaFabienne TamionAlice MoisanThomas DaixSébastien HantzFlora DelamaireV. ThibaultBertrand SouweineCecile HenquellLucile PicardFrançoise BotterelChristophe RodriguezArmand Mekontso DessapJean-Michel PawlotskyKeyvan RazaziRaphaël BellaïcheElie AzoulayJean-François TimsitGuillaume VoiriotNina de MontmollinStéphane MarotDjeneba Bocar FofanaCharles-Edouard LuytDjillali AnnaneFerhat MezianiLouis-Marie JandeauxSamira Fafi-KremerCédric DarreauJean ThominAnaïs DartevelSylvie LarratEvelyne SchvoererCédric HartardBéatrice La CombeSéverine HaouiseeSami HraeichPierre-Edouard FournierPhilippe ColsonEmmanuel CanetBerthe Marie ImbertGuillaume ThierySylvie PilletRémy CoudroyNicolas LevequeClément SaccheriValérie GiordanengoKada KloucheEdouard TuaillonCécile AubronAdissa TranJean-Marc TadiéJean-Christophe PlantierSophie Vallet
• Organismes : Centre de recherche en épidémiologie et santé des populations Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre]
• Publié dans Intensive Care Medicine le 27/10/2020

---

Source