Philippe JEAN-PIERRE

---

• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 02/10/2025
• Auteurs : Sébastien QuenotCouvidat-Gherardi PetruGherardi EugèneCanarelli JulieLeandri YanGeronimi Jean-BaptisteCerto DeborahSalort PhilippeLuzi ChristopheMarchiani Pierre-FrançoisPeraut MarcandriaDauphin ThibautVergé-Franceschi MichelTalamoni Jean-GuyFilippi Madeleine
• Organismes : Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Centre National de la Recherche Scientifique Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Università di Corsica Pasquale Paoli [Université de Corse Pascal Paoli] Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA) Institut de Recherche Montesquieu Université de Tours Laboratoire « Lieux, Identités, eSpaces, Activités » (UMR CNRS 6240 LISA)

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Claire ChatorMarion ChevrierJean-Sébastien FrenelFrédéric GuyonRenaud SabatierChristophe PomelThibault de la Motte RougePatricia PautierLaurence GladieffPhilippe FollanaPierre-Emmanuel ColomboThierry PetitCécile GuillemetFrédéric MarchalFabrice NarducciJean-David FumetManuel RodriguesLise BosquetRoman RouzierIsabelle Ray-Coquard
• Organismes : Centre Léon Bérard [Lyon] Institut Curie [Paris] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut Bergonié [Bordeaux] Institut Paoli-Calmettes Centre Jean Perrin [Clermont-Ferrand] Imagerie Moléculaire et Stratégies Théranostiques CRLCC Eugène Marquis Département de médecine oncologique [Gustave Roussy] Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle Institut de Cancérologie de Strasbourg Europe Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Centre de Recherche en Automatique de Nancy Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Service d'oncogénétique [Centre georges-François Leclerc] Institut Curie [Paris] UNICANCER [Paris] Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon]
• Publié dans Gynecologic Oncology le 25/10/2020

---

Résumé : Objective: Approximately 70 % of patients with epithelial ovarian cancer (EOC) will relapse. Beyond the platinum-free interval (PFI), predictive factors for efficacy of subsequent therapies are poorly understood. We evaluated the impact of the PFI on progression-free survival (PFS), overall survival (OS) and the role of therapies used at relapse. Methods: This retrospective study using the French ESME Ovarian Database included patients with first relapse of EOC after front-line platinum-based chemotherapy (PBCT). The impact of prognostic factors on survival was analyzed using multivariate Cox regression, with results expressed as hazard ratios, adjusted for patient and tumor characteristics, including a subgroup analysis of high-grade serous cancer. Results: 5558 patients, treated between 2010 and 2019 were included (median age 65 IQR 57-71). Median second- and third line PFS and OS were proportionally higher with PFI prolongation. Other factors influencing PFS and OS were BRCA mutation, FIGO stage, chemotherapy and maintenance regimens, and PS. PBCT was more effective than single-agent chemotherapy, even with a PFI < 6 months (PFSn2: adjusted HR = 0.48 95 %IC [0.43;0.53], OSn2: HR = 0.51 95 %IC [0.46;0.57]). Use of PARP inhibitors (PARPi) in second line seems to reduce outcomes in the third line. Findings were consistent in the HGSC subgroup. Conclusion: PFI remains an important prognostic factor but should no longer be the sole consideration for treatment selection at relapse in EOC, particularly in HGSC. The potential impact of prior PARPi maintenance on subsequent PBCT warrants investigation in prospective trials.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Audrey de JongHelena HuguetAnne BignonFrançois StéphanThomas GodetLucie ColletKarim AsehnouneAude SylvestreJuliette SautilletRaiko BlondonnetMartine FerrandiereYoann LauneySigismond LasockiAmélie RolléPierre-Marie FayolleLaurent MullerEmmanuel PardoNicolas TerziSéverin RaminBoris JungEmmanuel WeissPaer-Selim AbbackPhilippe GuerciBenjamine SartonHadrien RozéClaire DupuisJoel CoussonMarion FaucherVirginie LemialeBernard CholleyGerald ChanquesFouad BelafiaClaire ChauvetonEmmanuel FutierElie AzoulayNicolas MolinariSamir Jaber
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] CHU Montpellier = Montpellier University Hospital Université de Montpellier Université Paris-Saclay Hôpital Marie-Lannelongue Département Anesthésie, Réanimation et Soins Continus [Centre Jean Perrin - Clermont-Ferrand] Neuro-Dol Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Nord [CHU - APHM] Centre Hospitalier de la Polynésie Française Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire de Pointe-à-Pitre / Les Abymes [Guadeloupe] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts OcciTRAUMA network Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment and B-cells: Immunopathology, Cell Differentiation, and Cancer Hôpital Lapeyronie [CHU Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] AP-HP - Hôpital Beaujon Service d'Anesthésie et Réanimation [CHRU Nancy] Centre Hospitalier Universitaire de Toulouse Toulouse NeuroImaging Center Centre Hospitalier Universitaire de Bordeaux CHU Gabriel Montpied [Clermont-Ferrand] Unité de Nutrition Humaine Infection, Anti-microbiens, Modélisation, Evolution Hôpital universitaire Robert Debré [Reims] Institut Paoli-Calmettes AP-HP - Hôpital Saint-Louis [Paris] AP-HP - Hôpital Européen Georges Pompidou Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Saint Eloi [CHU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] AP-HP - Hôpital Saint-Louis [Paris] Université Paris Cité Institut Desbrest d'Epidémiologie et de Santé Publique Médecine de précision par intégration de données et inférence causale Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans British Journal of Anaesthesia le 28/10/2020

---

Résumé : Background - The optimal method to prevent treatment failure after tracheal extubation in postoperative critically ill patients with obesity and morbid obesity remains unknown. Methods - We conducted a secondary analysis of the EXTUBOBESE multicentre RCT comparing prophylactic noninvasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen [HFNO] and standard oxygen) in 585 postoperative critically ill patients with obesity (BMI ≥30 kg m) and morbid obesity (BMI ≥40 kg m). The primary outcome was treatment failure within 3 days after extubation, a composite of reintubation within 3 days (also analysed separately as secondary outcome), switch to the other study treatment, or premature study treatment discontinuation. The primary outcome analysis used a χ test. A Cox model was used for time without reintubation. Results - Treatment failure occurred in 39/292 patients (13.4%) in the NIV group and in 70/293 patients (23.9%) in the oxygen therapy group (absolute risk difference: -10.5; 95% confidence interval: -16.8 to -4.3). Similar results were found when analysing separately HFNO from standard oxygen in the oxygen therapy group. Reintubation rate was 8.6% (25 patients) in the NIV group and 9.9% (29 patients) in the oxygen therapy group (P=0.58). Interaction test was significant for level of obesity (P=0.045). Time without reintubation according to level of obesity significantly differed between NIV group and oxygen therapy group (P=0.02) in patients with BMI ≥40 kg m, but not in patients with 30≤BMI<40 kg m (P=0.70). Conclusions - Among postoperative critically ill adults with obesity undergoing tracheal extubation, our results suggest that use of noninvasive ventilation is effective to reduce treatment failure in comparison with oxygen therapy alone. These effects were more pronounced in patients with morbid obesity. Clinical trial registration - NCT04014920.

---

Fichiers liés : 2025 De jong et al., Noninvasive ventilation.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Yuqing LiuXiaojun LiPhilippe CiaisFrédéric FrappartXiangzhuo LiuEric G. CosioYi ZhengZanpin XingHuan WangLei FanMario Julian ChaubellWigneron J.-P.
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère National Sun Yat-sen University Interactions Sol Plante Atmosphère Peking University [Beijing] Southwest University [Chongqing] Jet Propulsion Laboratory Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

---

Résumé : The effective scattering albedo (omega) is a key parameter in the zero-order radiative transfer equation (known as the tau-omega model) for passive microwave retrieval of soil moisture (SM) and vegetation optical depth (VOD), quantifying the scattering energy loss as microwave radiation passes through the vegetation canopy. The scattering effects of vegetation are influenced by time-dependent factors such as plant geometry, vegetation water content, and canopy structure, suggesting that omega may vary over time. However, in the current tau-omega model-based retrieval algorithms used by orbiting L-band sensors, namely the Soil Moisture and Ocean Salinity (SMOS) and the Soil Moisture Active Passive (SMAP), omega is generally assumed to be time-invariant and assigned a fixed value according to land cover types. In this study, we aim to analyze and understand the spatio-temporal dynamics of omega, its relationship with vegetation water stress and the driving factors behind microwave scattering characteristics over tropical forests. By assuming a vegetation transmittance of zero for rigorously selected dense forest areas in the tropics, we calculated omega from the SMAP L-band radiometer observations during 2018-2023. Regarding the spatial distribution of omega, we observed distinct spatial dynamics within the same land cover type. The lowest omega values were typically found in the northeastern Amazon. Additionally, omega exhibited clear temporal dynamics, displaying a unimodal pattern in the Amazon and a bimodal pattern in the Congo. Clear polarization dependence of omega was observed, with values consistently higher at Horizontal (H-) polarization compared to Vertical (V-) polarization. Despite this, the seasonal patterns of omega are similar at both H- and V-polarizations. The seasonal variation of omega was found to be asynchronous with soil water availability indicated by root zone soil moisture (RZSM) across different regions. The shortest time lags (0-30 days) between omega and RZSM were observed in the densely vegetated northeastern Amazon, while the longest occurred in the northeastern Congo. A machinelearning based interpretation of the spatial variability of omega and time lag indicates that the values of omega are strongly and inversely related to canopy height, while the time lag is mainly associated with precipitation and soil water content. Our results deepen the understanding of the spatio-temporal dynamics of omega and could contribute to the improvement of SM and VOD retrieval algorithms, thereby enhancing the utility of these variables as indicators for monitoring vegetation carbon dynamics and phenology in dense tropical forests.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Jordi MiatelloAlba Palacios-CuestaPeter RadellAndré OberthuerStephen PlayforIrene Amores-HernándezSimon BarreaultRichard BiedermannMaria Teresa Charlo MolinaJuan Encarnación MartínezBenjamin KuehneSantiago MencíaMaria Dolores MéndezChristoph MenzelLuc MorinLidia OviedoJean-Eudes PiloquetMagnus FalkenhavPeter SackeyUwe TrieschmannPierre TissieresRamy CharbelClémence MaraisFlorent BaudinFleur Cour-AndlauerNicolas JoramJulien JegardMichael LevyJerome NaudinMaxence FernandesOmbeline RoignotJoelle BeaudetSandrine de SampaioYohan SorezePhilippe MeyerFrancois MoreauAna Maria Llorente de la FuenteOlga Ordóñez SáezHugo AhernRubén FerrerasCarmen Román-HernándezGuillermo Santos-SimarroRosa Maria Rodríguez SánchezElisa Mérida AlesElia Sánchez ValederrábanosManuel Fernández ElíasRaquel CiezaAlba CorchadoJosé Luis Unzueta-RochCristina Yun CastillaRaúl Montero YébolesLaura Díaz RuedaMónica Girona-AlarconSara Bobillo-PérezChristoph UlrichsMona StröhleinHans ProquittéRené HöhnChristoph ZürnMonika WolfAnand PatilPadmanabhan Ramnarayan
• Organismes : Agressions Pulmonaires et Circulatoires dans le Sepsis - UR Hospices Civils de Lyon
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

---

Source

---

• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/10/2025
• Auteurs : Pierre FerranPierre Chaffard-LuçonPierre VandierPhilippe JacobBernard PêcheurOlivier GohinLuc KleinJean-Christophe VidelinNathalie DurhinPhilippe GicquelJean-Michel MantinPhilippe PourquéIsabelle DelarbreJacques AbenBertrand MichelsPierre-Paul MarchiChristophe MaurietOlivier Marcotte
• Organismes : Service du commissariat des armées Institut Catholique de Paris (ICP) Service du commissariat des armées Centre Universitaire Rouennais d’Études Juridiques Ministère des armées – Ministère de la défense [France] (1946-....) Service du commissariat des armées Université Panthéon-Assas Centre d’Etudes et de Recherche en Droit Administratif, Constitutionnel, Financier et Fiscal Université Paris 1 Panthéon-Sorbonne Institut de Recherche juridique de la Sorbonne André Tunc Centre de Recherches Juridiques Service du commissariat des armées Direction de l'Administration Pénitentiaire Service du commissariat des armées Service du commissariat des armées Centre de Recherches Interdisciplinaires en Sciences humaines et Sociales de Montpellier Université de Montpellier Service du commissariat des armées Service du commissariat des armées Ministère des armées – Ministère de la défense [France] (1946-....) Service du commissariat des armées

---

Résumé : Contemporain et théoricien des guerres napoléoniennes, le Suisse Antoine-Henri de Jomini soulignait en 1838 que la logistique forme une des parties les plus essentielles de l’art de la guerre, au même titre que la stratégie ou la tactique. Cette affirmation peut assurément être posée au sujet de l’administration militaire. Dans l’histoire récente, les armées françaises ont été et sont encore confrontées à différentes conflictualités. Elles doivent poursuivre leurs efforts face aux nombreux défis qui apparaissent dès l’étape de la compétition afin de « gagner la guerre avant la guerre ». Parmi ces défis se trouvent une préparation, un concept d’emploi, des équipements permettant aux forces armées de faire face à leurs engagements opérationnels, mais aussi un soutien adapté à ceux-ci. En effet, les forces engagées sur les théâtres d’opérations sont autant confrontées à leur adversaire qu’aux contraintes de la vie en campagne qui nécessitent une grande variété de moyens : ravitaillements, transport, matériels, habillement, vivres… L’administration militaire permet aux armées de se préparer à leurs engagements opérationnels et participe activement au déroulement de ceux-ci, ainsi que l’a relevé la citation à l’ordre de l’armée décernée le 16 septembre 2024 par le ministre des armées au Service du commissariat des armées pour son soutien à l’opération « Barkhane » en Afrique sahélo-saharienne. Aussi, loin d’être un sujet déconnecté du terrain, l’administration militaire occupe au contraire une place centrale dans la pensée stratégique des armées. Afin de nourrir sa réflexion et de questionner ses pratiques, le Service du commissariat des armées a organisé le 8 décembre 2023 un colloque intitulé « le soutien des forces armées : l’administration militaire et sa singularité face aux situations de crises et de conflits ». Cet ouvrage regroupe les interventions qui ont concouru à cet évènement, augmenté de quelques contributions supplémentaires.

---

Fichiers liés : PDF Numerique_Actes colloques_Soutien Forces Armees__12-02-2026.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Jean-Yves BlayMaud ToulmondeThibaud ValentinNelly FirminSarah WatsonFlorence DuffaudEmmanuelle BompasMaria RiosMikael RoparsPhilippe AnractArmelle DufresneJustine GantzerLouis-Romée Le NailEsma SaadaAlice HervieuFrançois BertucciPascale Dubray-LongerasVincent CrennChristophe PerrinPauline SoibinetBenjamin VerretAntoine ItalianoGauthier DecanterGwenael FerronSebastien CarrereSylvie BonvalotMehdi BrahmiClémence HénonMariella Spalato-CerusoLoic LebellecAnne DucassouJulien Colard-ThomasSophie Piperno-NeumannJean-Camille MatteiFrancois GouinMathieu FaronThomas RyckewaertPierre MéeusCharles HonoréFrançois Le LoarerJean-Michel CoindreCarine NgoAlexandra MeurgeyMarie KaranianClaire Chemin-AiriauFrançoise DucimetiereMagali MorelleNicolas PenelAxel Le Cesne
• Organismes : Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Bergonié [Bordeaux] Oncopole Claudius Regaud Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut de Recherche en Cancérologie de Montpellier Institut régional de Cancérologie de Montpellier Institut Curie [Paris] Hôpital de la Timone [CHU - APHM] CRLCC René Gauducheau Centre Alexis Vautrin Hôpital Sud [CHU Rennes] AP-HP - Hôpital Cochin Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut de Cancérologie de Strasbourg Europe Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Régional Universitaire de Tours Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Centre de Recherche en Cancérologie de Marseille Institut Paoli-Calmettes Centre Jean Perrin [Clermont-Ferrand] Service des Urgences [CHU Nantes] Laboratoire Mécanismes d'Accidents Université Gustave Eiffel Institut Jean Godinot [Reims] Institut Gustave Roussy Institut Bergonié [Bordeaux] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Oncopole Claudius Regaud Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut de Recherche en Cancérologie de Montpellier Institut régional de Cancérologie de Montpellier Institut Curie [Paris] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Gustave Roussy Institut Bergonié [Bordeaux] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Oncopole Claudius Regaud Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut de Recherche en Cancérologie de Montpellier Institut régional de Cancérologie de Montpellier Institut Curie [Paris] Hôpital de la Timone [CHU - APHM] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Gustave Roussy Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Institut Gustave Roussy Institut Bergonié [Bordeaux] Institut Bergonié [Bordeaux] Institut Gustave Roussy Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut Gustave Roussy
• Publié dans The Lancet Regional Health - Europe le 21/04/2021

---

Résumé : Background Liposarcomas (LPS) are among the most common sarcomas, but gather a diversity of rare to ultrarare molecular subtypes whose presentations and natural histories are partially characterized. The aim of the work was to describe the presentation and outcome of the different LPS histotypes from the NETSARC+ registry. Methods NETSARC+ (netsarc.org) is a network of 26 reference sarcoma centers with specialized multidisciplinary tumor boards (MDTB), funded by the French INCA since 2010 aiming to improve the quality of care of sarcoma patients. Patients' characteristics, treatment and outcomes are collected in a nationwide database. This work describes the outcome of all LPS confirmed by central review pathology review and integrated between 2010 and 2023 in the NETSARC+ database. Findings 11,132 liposarcomas are included in the database for an estimated incidence of 11.5/10 6 /y. Median age was 65 (Q1-Q3: 53-74, range 0-97 y), with 6529 males (58.7%), with 4220 (37.9%) dedifferentiated (DDLPS), 1838 (16.5%) well differentiated LPS (WDLPS) & 2424 (21.8%) atypical lipomatous tumours (ALT), 1371 (12.3%) myxoid LPS (MyxLPS), 450 (4.0%) pleomorphic LPS (PLPS), 177 (1.6%) high grade myxoid LPS (HGMLPS), 24 (0.2%) mixed type liposarcomas (MTLPS), 14 (0.1%) myxoid pleomorphic LPS (MPLPS) and 614 (5.5%) non classified LPS (NCLPS). Age, sex and sites differed across histotypes, but overall, all histotypes were represent in all age groups and sites. We report first on a difference in the sex ratio of liposarcoma in different age groups. Women were less frequently affected with liposarcomas after 50, in DDLPS, MyxLPS and HGMLPS. The median overall survival of DDLPS was 144 months, significantly worse than that of MyxLPS (HR: 0.26 [95% CI 0.21–0.33]), PLPS (HR: 0.76 [95% CI 0.59–0.98]), HGMLPS (HR: 0.30 [95% CI 0.18–0.50]), WDLPS (HR: 0.30 [95% CI 0.24–0.37]), unclassified LPS (HR: 0.53 [95% CI 0.37–0.75]). In addition to a lower incidence, women aged >50 had a better relapse free and overall survival than male, while this was not observed in the group aged 50 or under. In multivariate analyses, size and age were independent prognostic factors for the most common subgroups, but specific prognostic parameters were observed in each molecular subgroup. Female >50 was an independent favorable prognostic factor for the largest groups of DDLPS. Interpretation In this nationwide series of pathology-confirmed LPS, the clinical presentation, management and survival of histotypes are very different with age-related sex differences favoring women >50. DDLPS is the subtype with the worse prognosis

---

Fichiers liés : main_1.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Émilie PicardFatima Domenica Elisa de PalmaSophia LoiodiceVincent CarbonnierSeiki AchiedoNoor MimounDiluxe MutaleSophie DoublierSylvère DurandMélanie BourginFanny AprahamianPierre CordierLouise GutterKatia JedeonMarie-Christine NaudPhilippe NoirezJean-Marc RicortLotfi SlimaniGuido KroemerFrancine Behar-CohenMaria Chiara MaiuriSylvie Babajko
• Organismes : Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Santé orale Centre de Recherche des Cordeliers Métabolisme, cancer et immunité = Metabolism, Cancer & Immunity [CRC] Métabolisme, cancer et immunité = Metabolism, Cancer & Immunity [CRC] Métabolisme, cancer et immunité = Metabolism, Cancer & Immunity [CRC] École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique Centre de Recherche des Cordeliers Santé orale Centre de Recherche des Cordeliers Performance, Santé, Métrologie, Société - EA 7507 Santé orale Ecole Normale Supérieure Paris-Saclay Santé orale Centre de Recherche des Cordeliers Institut Gustave Roussy Cancer Research and Personalized Medicine - CARPEM [Paris] Centre de Recherche des Cordeliers Métabolisme, Cancer et Immunité Santé orale
• Publié dans Environment International le 30/10/2020

---

Résumé : Exposure to environmental pollutants may contribute to various health disorders, often manifesting after a prolonged period of latency. The identification of early markers is, therefore, of paramount importance.

To achieve this objective, realistic models of environmental exposure were set up. Whereas most studies consider one substance or mixture with one target organ, here, in addition to the liver, two easily accessible sensitive organs, the eyes and teeth, were analyzed as good potential candidates to be original markers of environmental exposures. C57BL/6J mice were exposed to either sodium fluoride or a mixture of 15 endocrine-disrupting substances, or both, in their drinking water from the time of conception until 1 or 10 months after birth. The doses of these substances were chosen to be close to the tolerable daily intake.

All mice in test groups presented lower weight gain than controls with the most significant differences observed in females 30 days after birth. Alterations in the eye retina were detected as early as 1 month of age and considerably worsened by 10 months. Dental defects were observed in all test groups at the last time point. At that age, metabolic disruptions were identified through molecular metabolomic and RNAseq analyses, while histological analyses showed no significant defects in liver.

This study shows that chronic exposure to widespread toxicants resulted in hepatic metabolic disorders. However, the most evident histological and clinical signs were observed in eyes and teeth. These easily accessible stigmata may be used as early markers of low-dose exposure to environmental toxicants.

---

Fichiers liés : Picard, de Palma et al main_post print.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2025
• Auteurs : Antoine GavoilleFabien RollotRomain CaseyGuillaume MatheyEmmanuelle Le PageJonathan CironJérôme de SèzeAurélie RuetÉlisabeth MaillartPierre LabaugeHélène ZéphirArnaud KwiatkowskiCaroline PapeixGilles DeferChristine Lebrun-FrenayThibault MoreauDavid-Axel LaplaudEric BergerAnne-Laure DubessyPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al-KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagySolène MoulinJean-Philippe CamdessanchéInès DoghriMariana Sarov-RiviereKarolina HankiewiczCorinne PottierAmélie dos SantosChantal NifleFabien SubtilSandra VukusicFrançois CottonPascal DouekF. GuilleminAlexandre PachotJavier OlaizClaire Rigaud-BullyRomain MarignierGuillaume MatheyAnne KerbratDamien BiottiJean-Christophe OualletNicolas CollonguesOlivier OutteryckXavier MoissetNathalie DeracheMikael CohenAgnès FromontSandrine WiertlewskyMatthieu BereauBertrand AudoinClaire GiannesiniCaroline BensaGiovanni CastelnovoOmbeline FagniezBenjamin HebantMathieu VaillantSéverine JeaninAlain CréangeJean-Michel VallatPhilippe ConversStéphane BeltranCéline LabeyrieCarole HenryMarie CamuzeauxMaryline DelattreLaura TrottaCatherine GirodAmandine Ostermann-ZieglerDamien Le PortNoellie FreitasCarole BertheKaty-Kim LatasteKarima ZehrouniFrédéric PinnaJulie PetitSadou Safa DialloKarine DroulonCéline CallierAlexia ProtinMelinda MoyonChrystelle CappeEmilie DumontHanane AgherbiMarie BlanchereMarie-Pierre RanjevaAmandine da VeigaMaty Diop KaneChristine VimontMarjory CayolSafiyatou BaldeDaisy RousseauKarine FerraudGéraldine MeunierElise VarnierEdwige LescieuxHalima BourenaneStéphanie CossecÉmilie RaboisLynda BenammarAnaïs Beulaygue
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique - Epidémiologie clinique [Nancy] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de Neurologie [Strasbourg] Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale AP-HP - Hôpital de la Pitié Salpêtrière Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Saint Vincent de Paul [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université Paris Cité Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Service de Neurologie [CHU Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Service de Neurologie [CHRU Besançon] AP-HP - Hôpital de la Pitié Salpêtrière Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre Hospitalier Intercommunal de Poissy/Saint-Germain-en-Laye Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] AP-HP - Hôpital Henri-Mondor Service de Neurologie [CHU Limoges] Service de neurologie [Reims] Service de Neurologie [CHU de Saint-Étienne] Centre Hospitalier Régional Universitaire de Tours Service de neurologie [Le Kremlin Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] Hôpital NOVO Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre Hospitalier de Versailles André Mignot Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS
• Publié dans JAMA neurology le 24/10/2020

---

Résumé : Importance: In women with multiple sclerosis (MS), disease-modifying therapy (DMT) management during pregnancy might impact relapse risk. Objective: To estimate the effect of DMT management during pregnancy on MS relapse rate and compare different therapeutic strategies. Design, setting, and participants: This was a multicenter retrospective cohort study using data from January 1990 to December 2023. Data were extracted in December 2023 from the French MS registry. Among 52 955 women in the registry, we included pregnancies identified through childbirths in patients with relapsing-onset MS who were monitored for at least 18 months before delivery and 9 months after. Pregnancies occurring less than 18 months apart or with missing month of birth were excluded. Exposures: Mediation analysis was used to estimate the total, direct, and indirect (mediated by DMT management) effects of pregnancy. Different therapeutic strategies were compared: DMT interruption, switching to or maintaining interferon β or glatiramer acetate, switching to or maintaining natalizumab until the third trimester, and switching to or maintaining intravenous anti-CD20 and interrupting it 3 months before conception. Main outcomes and measures: The primary outcome was the annualized relapse rate (ARR) during the preconception, gestation, and postpartum periods. Within a causal inference framework, counterfactual ARRs were estimated using longitudinal g-computation, combining a random forest algorithm for predicting DMTs, and a mixed-effects Poisson model for relapses. Results: We included 6341 pregnancies occurring in 4998 women (mean [SD] age at conception, 31.5 [4.5] years). DMT management during pregnancy significantly increased ARR during gestation (causal rate ratio [cRR], 1.13; 95% CI, 1.06-1.22) and postpartum (cRR, 1.08; 95% CI, 1.01-1.16) periods. This led to a deleterious total effect of pregnancy on ARR, particularly in women receiving natalizumab before pregnancy with prolonged interruption (ie, interruption before the second trimester or resumption more than 3 months after delivery; cRR, 2.18; 95% CI, 1.76-2.69), and in women receiving fingolimod (cRR, 2.15; 95% CI, 1.60-2.93). Compared to DMT interruption, anti-CD20 strategy was the most effective (cRR, 0.38; 95% CI, 0.25-0.52), followed by the natalizumab strategy with short interruption (cRR, 0.80; 95% CI, 0.71-0.90), whereas interferon β (cRR, 0.93; 95% CI, 0.86-0.99) and glatiramer acetate strategies (cRR, 0.91; 95% CI, 0.84-0.99) were less effective. Conclusion: In this study, DMT management during pregnancy significantly increased relapse risk, particularly in patients receiving natalizumab with prolonged interruption or fingolimod. The strategy based on the use of anti-CD20 before pregnancy was the most effective to mitigate this risk.

---

Fichiers liés : Gavoille - 2025 - Therapeutic Management during Pregnancy on Relapse Risk in.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 26/09/2025
• Auteurs : Francis SchneiderSophie HelleJean-Marc StrubFrançois-Xavier von HunolsteinPierre SchaafPhilippe LavalleFrancesco ScavelloMarie-Hélène Metz-Boutigue
• Organismes : Biomatériaux et Bioingénierie Fédération de Médecine Translationnelle de Strasbourg Biomatériaux et Bioingénierie Laboratoire de Spectrométrie de Masse BioOrganique [Strasbourg] Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Istituto Clinico Humanitas [Milan] Biomatériaux et Bioingénierie
• Publié dans Antibiotics le 24/10/2020

---

Résumé : Background: Whether therapeutic albumin (ThHSA) can serve as a defense tool in Candida species (spp.) infections is still a matter of debate, although many physicians are in the habit of infusing ThHSA to restore the physiological concentration of endogenous human serum albumin (HSA). Given the need for innovative anti-Candida strategies, we assessed in vitro the role of ThHSA alone or in combination with voriconazole (VCZ) in combating Candida spp. growth and the role of bovine serum albumin (BSA)-used as a substitute for HSA-with two endogenous bovine antimicrobial peptides in combating C. albicans and other microbes. Results: The combination of ThHSA with VCZ enhanced the antifungal effect on C. albicans, sensitive C. tropicalis, sensitive C. glabrata, and C. lusitaniae. However, for resistant C. tropicalis, the combination of ThHSA with VCZ promoted yeast growth, and VCZ tended to suppress the antimicrobial effect of ThHSA on resistant C. glabrata. As to the possible transposition of ThHSA-type properties to BSA (as regards the growth inhibition of other pathogens), we tested combinations of BSA with two physiological chromogranin A-derived antimicrobial peptides (catestatin and cateslytin). BSA enhanced significantly the activity of catestatin (but not cateslytin) in combating C. albicans, A. fumigatus, and M. luteus, but was inactive against S. aureus and E. coli. Conclusions: Our experiments support the fact that albumins display intrinsic antimicrobial properties, with an unpredictable growth inhibitory effect on various microbes. ThHSA can thus be an adjunctive tool for more efficient care of some, though not all, infections. The interaction of BSA with catestatin and cateslytin is related to their structure, with BSA significantly enhancing the effect of catestatin but not that of cateslytin.

---

Fichiers liés : antibiotics-14-00974-v4.pdf

---

Source