Philippe JEAN-PIERRE

Lack or excess of autophagy leads to premature leaf senescence probably owing to unbalanced nutrient management

Type de publi. : Article dans une revue
Date de publi. : 04/06/2025
Auteurs : Maxence JamesJacques TrouverieAnne MarmagneFabien ChardonJulie FrémontPhilippe EtienneCéline Masclaux‐daubresse

Lack or excess of autophagy leads to premature leaf senescence probably owing to unbalanced nutrient management

Type de publi. : Article dans une revue
Date de publi. : 04/06/2025
Auteurs : Maxence JamesJacques TrouverieAnne MarmagneFabien ChardonJulie FrémontPhilippe EtienneCéline Masclaux‐daubresse
Organismes : Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay
Publié dans Annals of Botany le 01/11/2020

Résumé : Macroautophagy is essential for the degradation and recycling of various macromolecules in eukaryotic cells. In plants, autophagy is involved in the degradation of damaged chloroplasts in response to stress. Autophagy is a key player in nitrogen management at the whole-plant level, and autophagy mutants display strong defects in nitrogen remobilization and early leaf senescence phenotypes, especially during nitrogen source limitation. It is known that leaf senescence is associated with nutrient remobilization processes and is induced by nitrate limitation. However, it remains to be determined which actors are involved in this interplay and whether nutrient remobilization acts as a signal that enhances leaf senescence or whether senescence-associated chloroplast degradation promotes nutrient remobilization. In this context, our aim was to demine whether the level of autophagic activity controls leaf longevity and influences the progress of leaf senescence, balancing resources and waste management. Methods In this study, we used Arabidopsis autophagy knock-out mutants (atg) and plants overexpressing autophagy-associated genes (ATG8-OE) to compare their phenotypes with wild-type in both nitrate-sufficient conditions and nitrate starvation. Key Results The transfer from nitrate-sufficient conditions to nitrate starvation accelerated leaf senescence in all the genotypes. Unexpectedly, in both nitrate-sufficient and nitrate-starved conditions, both atg mutants and ATG8 overexpressors exhibited earlier leaf senescence phenotypes compared with wild-type. Given that autophagy is a longevity factor, the more severe leaf senescence phenotype of overexpressors was puzzling. This study highlights a relationship between autophagy, nitrogen remobilization and leaf senescence and shows how the fine-tuning of nutrient management can influence senescence onset. Conclusions The fine-tuning of autophagy is necessary to control leaf senescence.

Fichiers liés : mcaf050.pdf

Source

Style in Eight Syllables: Metric Annotation and Stylometry of Chrétien de Troyes and Contemporaries

Type de publi. : Communication dans un congrès
Date de publi. : 03/06/2025
Auteurs : Jean-Baptiste CampsFlorian CafieroPhilippe Chaumet-RiffaudDamien ConceicaoUlysse GodreauÉmilie GuidiAlexandre Lionnet-RollinThéo MoinsPierre-Alexandre NistorBenedetta Salvati

Style in Eight Syllables: Metric Annotation and Stylometry of Chrétien de Troyes and Contemporaries

Type de publi. : Communication dans un congrès
Date de publi. : 03/06/2025
Auteurs : Jean-Baptiste CampsFlorian CafieroPhilippe Chaumet-RiffaudDamien ConceicaoUlysse GodreauÉmilie GuidiAlexandre Lionnet-RollinThéo MoinsPierre-Alexandre NistorBenedetta Salvati
Organismes : Centre Jean Mabillon École nationale des chartes médialab (Sciences Po) Institut Hospitalo-Universitaire FOReSIGHT École nationale des chartes École nationale des chartes Université Paris Sciences et Lettres Centre Jean Mabillon Centre Jean Mabillon École nationale des chartes École nationale des chartes Centre Jean Mabillon

Résumé : Authorship attribution for medieval texts such as those of Chrétien de Troyes poses unique challenges due to textual transmission, language variation, and limited reference corpora. In this context, it might be useful to draw as much stylistic information as possible from the texts, beyond most common features such as function words. This paper presents an ongoing project to include metrical annotation (with a focus on prosody) in the stylometric analysis of Medieval French, to enhance support vector machine (SVM)-based authorship attribution. The case at hand focuses on the attribution of the works of Chrétien de Troyes and his contemporaries.

Fichiers liés : abstract_Chrestien_Camps_20250605.pdf

Source

Large live biomass carbon losses from droughts in the northern temperate ecosystems during 2016-2022

Type de publi. : Article dans une revue
Date de publi. : 02/06/2025
Auteurs : Xiaojun LiPhilippe CiaisRasmus FensholtJérôme ChaveStephen SitchJ. CanadellMartin BrandtSassan S SaatchiXiangming XiaoShengli TaoHuan WangClément AlbergelHui YangFrédéric FrappartMengjia WangAna BastosPhilippe MaisongrandeYuanwei QinZanpin XingTianxiang CuiLing YuLei HeYi ZhengXiangzhuo LiuYuqing LiuAurelien de TruchisWigneron J.-P.

Large live biomass carbon losses from droughts in the northern temperate ecosystems during 2016-2022

Type de publi. : Article dans une revue
Date de publi. : 02/06/2025
Auteurs : Xiaojun LiPhilippe CiaisRasmus FensholtJérôme ChaveStephen SitchJ. CanadellMartin BrandtSassan S SaatchiXiangming XiaoShengli TaoHuan WangClément AlbergelHui YangFrédéric FrappartMengjia WangAna BastosPhilippe MaisongrandeYuanwei QinZanpin XingTianxiang CuiLing YuLei HeYi ZhengXiangzhuo LiuYuqing LiuAurelien de TruchisWigneron J.-P.
Organismes : Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] IT University of Copenhagen Centre de Recherche sur la Biodiversité et l'Environnement University of Exeter CSIRO Environment Business Unit Københavns Universitet = University of Copenhagen = Université de Copenhague Southwest University [Chongqing] University of Oklahoma Peking University [Beijing] Peking University [Beijing] European Centre for Space Applications and Telecommunications Peking University [Beijing] Interactions Sol Plante Atmosphère Zhengzhou University Universität Leipzig = Leipzig University Centre National d'Études Spatiales [Toulouse] Hohai University Interactions Sol Plante Atmosphère Nanjing Forestry University Southwest University [Chongqing] Chinese Academy of Agricultural Sciences National Sun Yat-sen University Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Kayrros Interactions Sol Plante Atmosphère
Publié dans Nature Communications le 23/10/2020

Résumé :

Northern ecosystems (≥ 30°N) have been accumulating vegetation biomass carbon in recent decades, but increasing droughts and wildfires threaten this carbon sink. Here, we analyse annual changes in live vegetation biomass in northern ecosystems using low-frequency microwave satellite observations at 25 km spatial resolution from 2010 to 2022. We find that live biomass carbon stocks have undergone a reversal from a positive to a negative trend during the study period with 2016 marking the turning point. During 2016-2022, live biomass carbon stocks decreased at a rate of À0:20 À0:11 À0:26 PgC yr -1 across northern ecosystems, primarily in temperate biomes (À0:26 À0:17 À0:33 PgC yr -1 ). The annual mean gross loss of 4% of live biomass carbon in this region during 2016-2022 reflects high interannual variability, with significant losses associated with droughts and a further drop of À0:60 À0:47 À0:75 PgC in the very dry year of 2022. Our findings highlight the vulnerability of live biomass carbon stocks to emerging climate-induced disturbances in northern ecosystems, challenging the sustainability of the current large terrestrial carbon sink in this key region for the global carbon balance.

Northern ecosystems (north of 30°N) hold about 41% of the world's forest area 1 , and are critical for mitigating global warming 2,3 , contributing an estimated 1.4-2.0 PgC annually to the global terrestrial carbon sink 4 . In recent decades, rising CO 2 levels and global warming have been reported to increase mid-and high-latitude vegetation productivity by lengthening the growing season 5 , which has resulted in a 'greening' trend as observed by optical satellite systems 6 . Concordantly, multiple lines of evidence from forest inventories 7,8 and satellite-based studies 9-11 suggest that biomass carbon has increased in northern ecosystems in recent decades.

Climate hazards, however, may have affected the biomass carbon budget of northern ecosystems as a result of increased wildfire frequency 12 , extensive drought-induced tree mortality 13,14 and unprecedented scale of insect outbreaks 15 . Previous studies have indicated that threats to forest carbon sinks have increased in North America 16-18 and Europe 19-21 over recent decades due to tree mortality caused by very high temperatures and droughts. Wildfires, a main driver of Siberian and Canadian boreal forest disturbances, have been reported to cause large carbon emissions during recent extreme fire years 12,22 and have even led to parts of Siberia turning into a carbon source 13,23 . Compound droughtsheat waves (typically characterized by low soil moisture and high air temperatures) and wildfires have affected the northern Hemisphere in

Fichiers liés : s41467-025-59999-2.pdf

Source

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Audrey OnfroyFrancette Jean-LouisP. Le CorvoisierFanny CoulpierKevin MuretEric BonnetRaphaele ArrouasseCaroline BoucleSalwa AbidÉmilie SbidianChristina BergqvistPierre WolkensteinVeronique GodotJean‐françois DeleuzeYves LévyPiotr TopilkoÉtienne AudureauSophie Hüe

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Audrey OnfroyFrancette Jean-LouisP. Le CorvoisierFanny CoulpierKevin MuretEric BonnetRaphaele ArrouasseCaroline BoucleSalwa AbidÉmilie SbidianChristina BergqvistPierre WolkensteinVeronique GodotJean‐françois DeleuzeYves LévyPiotr TopilkoÉtienne AudureauSophie Hüe
Organismes : Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Institut National de la Santé et de la Recherche Médicale Institut Mondor de Recherche Biomédicale Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Institut National de la Santé et de la Recherche Médicale Institut National de la Santé et de la Recherche Médicale Institut Mondor de Recherche Biomédicale Institut National de la Santé et de la Recherche Médicale Epidemiology in Dermatology and Evaluation in Therapeutics Epidemiology in Dermatology and Evaluation in Therapeutics Institut National de la Santé et de la Recherche Médicale Epidemiology in Dermatology and Evaluation in Therapeutics Institut Mondor de Recherche Biomédicale Centre National de Recherche en Génomique Humaine Centre d'Etude du Polymorphisme Humain Centre de référence, d’innovation, d’expertise et de transfert Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Assistance publique - Hôpitaux de Paris (AP-HP) Institut Mondor de Recherche Biomédicale Assistance publique - Hôpitaux de Paris (AP-HP)
Publié dans Journal of the European Academy of Dermatology and Venereology le 27/10/2020

Résumé : Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting approximately 1% of the global population. Its pathogenesis involves both aberrant keratinization and autoinflammation, but the temporal relationship between these processes remains unclear. Objective: To investigate the role of HF stem cell (HF-SC) fate in the early pathogenesis of HS. Methods: We performed single-cell RNA sequencing of HF cell populations from HS patients and healthy donors. We then analysed HF cell composition isolated from perilesional skin of 49 HS patients and integrated these data with clinical phenotypes to define disease endotypes. Results: Our data revealed two distinct differentiation trajectories of HF stem cells (HF-SCs): one leading to interfollicular epidermis (IFE) basal cells enriched in inflammatory pathways, and another giving rise to outer root sheath (ORS) cells associated with keratinization. In HS lesions, both populations displayed altered inflammatory phenotypes and were closely linked to immune cell infiltration, pointing to a role in disease heterogeneity. By integrating clinical features with HF cell composition from 49 HS patients, we identified three major endotypes: (i) an inflammatory subtype, marked by T cell infiltration and an expansion of IFE basal cells; (ii) a keratinizing subtype, characterized by ORS enrichment and minimal inflammation; and (iii) a mixed subtype, exhibiting features of follicular remodelling, fistula formation and variable immune involvement. Conclusion: These findings provide novel insights into the epithelial-immune interactions that drive HS and support a stratified therapeutic approach tailored to distinct epithelial dysfunctions.

Fichiers liés : Acad Dermatol Venereol - 2025 - Onfroy - Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis.pdf

Source

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Sylvain RheimsFatima ChorfaVéronique MichelEdouard HirschLouis MaillardLuc ValtonFabrice BartolomeiPhilippe DerambureVincent NavarroJulien BiberonArielle CrespelAnca NicaMartine Lemesle MartinLaure MazzolaJerome PetitVincent RosseroSébastien BoulogneMathilde LeclercqLaurent BezinCatherine MercierPascal RoyPhilippe Ryvlin

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Sylvain RheimsFatima ChorfaVéronique MichelEdouard HirschLouis MaillardLuc ValtonFabrice BartolomeiPhilippe DerambureVincent NavarroJulien BiberonArielle CrespelAnca NicaMartine Lemesle MartinLaure MazzolaJerome PetitVincent RosseroSébastien BoulogneMathilde LeclercqLaurent BezinCatherine MercierPascal RoyPhilippe Ryvlin
Organismes : Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Service de Biostatistiques [Lyon] CHU de Bordeaux Pellegrin [Bordeaux] Centre de référence des épilepsies rares [CHU Strasbourg] Service de neurologie [CHRU Nancy] Ingénierie Moléculaire, Cellulaire et Physiopathologie Centre de recherche cerveau et cognition Centre Hospitalier Universitaire de Toulouse Institut de Neurosciences des Systèmes Service d'Epileptologie et de Rythmologie Cérébrale [Hôpital de la Timone, AP-HM] Service de neurophysiologie clinique Pharmacologie de la mort neuronale et de la plasticité cérébrale CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Centre Hospitalier Régional Universitaire de Tours Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Institut National de la Santé et de la Recherche Médicale Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Service de Neurophysiologie Clinique (CHU Dijon) Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Médical de la Teppe Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Équipe de Recherche Translationnelle et Intégrative en Épilepsie - Translational and Integrative Group in Epilepsy Research Team Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Centre Thématique de Recherche et de Soins - Institut des Épilepsies de l'Enfant et de l'Adolescent = IDEE Epilepsy Institute Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
Publié dans Epilepsia Open le 09/01/2019

Résumé : Abstract Objective Evaluating the efficacy of an opioid antagonist, naloxone (NLX), to reduce the severity of post‐ictal hypoxemia and immobility after focal to bilateral tonic–clonic seizures (FBTCS). Methods ENALEPSY is a double‐blind placebo (PCB)‐controlled trial conducted in patients with focal epilepsy undergoing long‐term video‐EEG monitoring (LTM). Patients with a FBTCS during LTM were randomized 1:1 to receive intravenous NLX or PCB within the 2 min following the end of FBTCS. After database lock, a discrepancy between the allocated arm and the received treatment was detected, resulting in a 4:1 NLX:PCB ratio. To further explore the efficacy of NLX, we used historical control (HC) data collected in patients included in the REPO 2 MSE study whose characteristics matched those of patients randomized in ENALEPSY. The efficacy of NLX was then assessed versus PCB and versus HC. The primary endpoint was the delay between the end of the seizure and recovery of SpO 2 ≥ 90%. Secondary efficacy outcomes included desaturation nadir and duration of the post‐ictal immobility. Results 33 patients contributed to the NLX group, 7 to the PCB group, and 43 to the HC group. The proportion of FBTCS type 1 or 3 was 84% in NLX, 100% in PCB, and 84% in HC. NLX did not improve the delay of recovery of SpO 2 ≥ 90% or the desaturation nadir. By contrast, the duration of the post‐ictal immobility differed across groups. The time to mobility recovery within the first 5 min post‐ictal was very similar in the PCB (200.3 ± 215.8 s) and HC (194.4 ± 192.0 s) groups, and significantly shorter in the NLX group (128.9 ± 151.1 s) when compared to HC (Hazard Ratio, 1.84; 95% CI, 1.11–3.05; p = 0.021). Significance NLX did not prevent post‐ictal respiratory dysfunction but might reduce the duration of post‐ictal immobility. Confirmation of this effect and its impact on SUDEP risk will require additional studies. Plain Language Summary Release of endogenous opioids might participate in the severity of post‐ictal hypoxemia and immobility after focal to bilateral tonic–clonic seizures (FBTCS). We conducted a multicenter double‐blind randomized placebo‐controlled trial evaluating the efficacy of an opioid antagonist, naloxone (NLX), administered within 2 min following the end of FBTCS. The efficacy of NLX was further explored with a comparison with historical control. NLX did not improve the delay of recovery or the severity of post‐ictal hypoxemia. Post‐ictal immobility was significantly shorter in the NLX group when compared to historical control. The impact of these results on SUDEP prevention will require additional studies.

Fichiers liés : Epilepsia Open - 2025 - Rheims - Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to.pdf

Source

Actualisation des recommandations de prise en charge des pneumonies aiguës communautaires chez l'adulte par la Société de Pathologie Infectieuse de Langue Française (SPILF) et la Société de Pneumologie de Langue Française (SPLF). Avec le soutien de la Société de Réanimation de Langue Française, (SRLF), de la Société Française de Microbiologie (SFM), de la Société Française de Radiologie (SFR) et de la Société Française de Médecine d'Urgence (SFMU)

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Aurélien DinhFrançois BarbierJean-Pierre BedosMathieu BlotVincent CattoirYann-Eric ClaessensXavier DuvalPierre FillâtreMaxime GautierYann GueganJarraud SAlban Le MonnierDavid LebeauxPaul LoubetConstance de MargeriePhilippe SerayetYacine Tandjaoui-LambotteEmmanuelle VaronYves WelkerDamien Basille

Actualisation des recommandations de prise en charge des pneumonies aiguës communautaires chez l'adulte par la Société de Pathologie Infectieuse de Langue Française (SPILF) et la Société de Pneumologie de Langue Française (SPLF). Avec le soutien de la Société de Réanimation de Langue Française, (SRLF), de la Société Française de Microbiologie (SFM), de la Société Française de Radiologie (SFR) et de la Société Française de Médecine d'Urgence (SFMU)

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Aurélien DinhFrançois BarbierJean-Pierre BedosMathieu BlotVincent CattoirYann-Eric ClaessensXavier DuvalPierre FillâtreMaxime GautierYann GueganJarraud SAlban Le MonnierDavid LebeauxPaul LoubetConstance de MargeriePhilippe SerayetYacine Tandjaoui-LambotteEmmanuelle VaronYves WelkerDamien Basille
Organismes : Hôpital Raymond Poincaré [AP-HP] Hôpital Ambroise Paré [AP-HP] Centre Hospitalier Régional d'Orléans Service de réanimation [CH Versailles] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN bactériens et médecine Hôpital Princesse Grace [Monaco] Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique Centre hospitalier Saint-Brieuc Paimpol Tréguier Hôpital Simone Veil [Eaubonne] Pathogenèse des légionelles- Legionella pathogenesis [CIRI] Centre National de Référence des Légionelles Hospices Civils de Lyon Groupe Hospitalier Paris Saint-Joseph Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Nîmes Hopital Saint-Louis [AP-HP] Chercheur indépendant Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier Intercommunal de Créteil Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Pneumologie [CHU Amiens]
Publié dans Médecine et Maladies Infectieuses Formation le 24/01/2023

Résumé : La Pneumonie Aiguë Communautaire (PAC) présumée d'origine bactérienne est une pathologie fréquente plus ou moins grave qui peut être prise en charge en ambulatoire ou à l'hôpital, voire en soins critiques. Les Sociétés de Pathologies Infectieuses (SPILF) et de Pneumologie de Langue Française (SPLF) ont coordonné, en partenariat avec les sociétés française de microbiologie (SFM), de médecine d'urgence (SFMU), de radiologie (SFR), de réanimation de langue française (SRLF), et des représentants de la médecine générale, une mise à jour de la prise en charge des recommandations précédentes qui dataient de 2010. Sur le plan thérapeutique, elles définissent le choix de l'antibiothérapie probabiliste initiale, les indications de la bithérapie, des bêta-lactamines anti-Pseudomonas, la durée de traitement antibiotique, ainsi que l'indication et les modalités de prescription des corticostéroïdes systémiques. Sur le plan biologique, les indications des biomarqueurs et des examens à visée microbiologique ont été précisées. Sur le plan radiologique, la place des différents examens pour le diagnostic et le suivi des PAC ont été revues : radiographie, échographie pleuropulmonaire et scanner thoracique.

Fichiers liés : Dinh - 2025 - Actualisation des recommandations de prise en charge des pneumonies aiguës communautaires chez l'adulte _MMIFMC-D-25-00002.pdf

Source

Recommandations pour la prise en charge des pneumonies d’inhalation – Société de Pathologie Infectieuse de Langue Française 2025

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Sylvain DiamantisThibault FraisseEric BonnetVirginie PrendkiClaire AndréjakMarie-Anne AuquierCarla Garcia CarmonaEric FarfourPierre FillâtreSébastien GallienGaëtan GavazziAnne-Laure HouistJulie LourtetMathilde PerrinEmilie PietStanislas RebaudetYves RollandJ.P. LanoixAlain Putot

Recommandations pour la prise en charge des pneumonies d’inhalation – Société de Pathologie Infectieuse de Langue Française 2025

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Sylvain DiamantisThibault FraisseEric BonnetVirginie PrendkiClaire AndréjakMarie-Anne AuquierCarla Garcia CarmonaEric FarfourPierre FillâtreSébastien GallienGaëtan GavazziAnne-Laure HouistJulie LourtetMathilde PerrinEmilie PietStanislas RebaudetYves RollandJ.P. LanoixAlain Putot
Organismes : Centre Hospitalier de Melun Service de maladies infectieuses [CH Melun] Centre Hospitalier Alès-Cévennes Université Paris 8 Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] CHU Amiens-Picardie Pneumologie [CHU Amiens] Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 CHU Amiens-Picardie Hôpital Forcille Hôpital Foch [Suresnes] Centre hospitalier Saint-Brieuc Paimpol Tréguier Dynamic Microbiology - EA 7380 CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU Henri Mondor [Créteil] Groupe Hospitalier Paris Saint-Joseph Centre Hospitalier Sud Francilien - Centre Hospitalier d'Evry Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Institut Hospitalier Universitaire HealthAge Centre d'Epidémiologie et de Recherche en santé des POPulations Maladies infectieuses et tropicales [CHU Amiens] Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
Publié dans Médecine et Maladies Infectieuses Formation le 24/01/2023

Source

Clinical features and comorbidities associated with migraine in bipolar disorder: Results from the FACE-BD cohort

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Ludovic SamalinOphélia GodinXavier MoissetAmbre ChalayerAgnes PelletierAntoine LefrèrePaul RouxMircea PolosanAnamaria BogdanRaymund SchwanCaroline DubertretBruno AouizerateRaoul BelzeauxRomain ReyDominique JanuelMichel WalterAntoine YrondiEmmanuel HaffenPhilippe CourtetFrank BellivierMarion LeboyerBruno EtainEmilie OliéPierre-Michel Llorca

Clinical features and comorbidities associated with migraine in bipolar disorder: Results from the FACE-BD cohort

Type de publi. : Article dans une revue
Date de publi. : 01/06/2025
Auteurs : Ludovic SamalinOphélia GodinXavier MoissetAmbre ChalayerAgnes PelletierAntoine LefrèrePaul RouxMircea PolosanAnamaria BogdanRaymund SchwanCaroline DubertretBruno AouizerateRaoul BelzeauxRomain ReyDominique JanuelMichel WalterAntoine YrondiEmmanuel HaffenPhilippe CourtetFrank BellivierMarion LeboyerBruno EtainEmilie OliéPierre-Michel Llorca
Organismes : Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] CHU Henri Mondor [Créteil] CHU Clermont-Ferrand Neuro-Dol Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Institut Mondor de Recherche Biomédicale CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Université de Lorraine Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Université Sorbonne Paris Cité Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Institut de Génomique Fonctionnelle Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondation FondaMental [Créteil] Centre Hospitalier le Vinatier [Bron] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre de Recherche Clinique [Neuilly-sur-Marne] Université Sorbonne Paris Nord Hopital de Bohars - CHRU Brest Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Toulouse NeuroImaging Center Centre Hospitalier Universitaire de Toulouse Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) Centre d'Investigation Clinique de Besançon Centre Hospitalier Régional Universitaire de Besançon Fondation FondaMental [Créteil] Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [Montpellier] Fondation FondaMental [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Hôpital Lariboisière-Fernand-Widal [APHP] Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] CHU Henri Mondor [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Hôpital Lariboisière-Fernand-Widal [APHP] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand
Publié dans Journal of Affective Disorders le 31/10/2020

Résumé : Introduction: Individuals with bipolar disorder (BD) frequently experience comorbid medical conditions, with migraine being among the most common. While research on migraine prevalence in BD is growing, the associated clinical features, comorbidities, and treatments remain underexplored and sometimes inconsistent. This study aimed to investigate the clinical features and comorbidities associated with migraine in a large cohort of adults with BD. Methods: We assessed 4348 outpatients with BD attending FondaMental Advanced Centers of Expertise. Sociodemographic and clinical data were collected using a standardized procedure. Lifetime diagnoses for medical disorders, including migraine, were based on self-reports, clinician assessments, and medical history reviews. Multivariable logistic regression was used to assess associations between migraine and sociodemographic factors, clinical characteristics, comorbidities, and medications. Results: The prevalence of comorbid migraine in BD was 20 %, with 29.1 % in BD type II and 19.9 % in BD type I. Multivariable analysis found that migraine was associated with younger age (OR = 0.98, CI 95 % 0.97-0.99), females (OR = 2.15, CI 95 % 1.56-2.95), sleep disturbances (OR = 1.06, CI 95 % 1.02-1.11), childhood trauma (OR = 1.01, CI 95 % 1.00-1.02), hypertension (OR = 1.88, CI 95 % 1.13-3.15), psoriasis (OR = 1.61, CI 95 % 1.01-2.56), asthma (OR = 1.65, CI 95 % 1.02-2.67) and lower use of second-generation antipsychotics (OR = 0.65, CI 95 % 0.48-0.87). Conclusion: Migraine is common in BD, especially in younger individuals, females, and those with sleep disturbances or a history of trauma, who also experience a higher clinical burden. These overlapping factors highlight the need for an integrated treatment approach, addressing mood stabilization, sleep management, and trauma support to reduce migraine burden in BD patients.

Fichiers liés : Samalin et al 2025.pdf

Source

Randomized phase II trial evaluating the combination of TG4001, an HPV16 therapeutic vaccine, and avelumab (ave) in patients (pts) with immunotherapy-naïve recurrent and/or metastatic (R/M) HPV16-positive cervical or anogenital cancer.

Type de publi. : Communication dans un congrès
Date de publi. : 30/05/2025
Auteurs : Christophe Le TourneauFrederic RollandOlivier CapitainPhilippe CassierJean David FumetSébastien SalasAmaury DasteLuis MansoMaria-Jose Bermejo-PerezAntonio CasadoLaura MansiPatricia PautierOlivier LantzEmmanuelle DochyClémentine Spring-GiustiKatell Bidet HuangHakim MakhloufiCéline HalluardAnnette TavernaroJean-Pierre Delord

Randomized phase II trial evaluating the combination of TG4001, an HPV16 therapeutic vaccine, and avelumab (ave) in patients (pts) with immunotherapy-naïve recurrent and/or metastatic (R/M) HPV16-positive cervical or anogenital cancer.

Type de publi. : Communication dans un congrès
Date de publi. : 30/05/2025
Auteurs : Christophe Le TourneauFrederic RollandOlivier CapitainPhilippe CassierJean David FumetSébastien SalasAmaury DasteLuis MansoMaria-Jose Bermejo-PerezAntonio CasadoLaura MansiPatricia PautierOlivier LantzEmmanuelle DochyClémentine Spring-GiustiKatell Bidet HuangHakim MakhloufiCéline HalluardAnnette TavernaroJean-Pierre Delord
Organismes : Institut Curie [Paris] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Léon Bérard [Lyon] Lipides - Nutrition - Cancer [Dijon - U1231] Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique Assistance Publique - Hôpitaux de Marseille Hôpital Saint-André [Bordeaux] Aston University [Birmingham] Department of Medical Oncology Hôpital Jean Minjoz [Besançon] Département de médecine oncologique [Gustave Roussy] Immunité et cancer Centre d'Investigation Clinique en Biotherapie des cancers Université Paris Sciences et Lettres Transgene SA [Illkirch] Institut Universitaire du Cancer de Toulouse - Oncopole Oncopole Claudius Regaud Centre de Recherches en Cancérologie de Toulouse

Résumé : 2638 Background: Human papillomavirus (HPV) is a small DNA virus associated with cervical, anogenital (AG) cancers and squamous cell carcinoma of the head and neck. TG4001 is a therapeutic vaccine based on modified vaccinia virus Ankara with insertion of modified non-oncogenic HPV-16 E6 and E7 antigens and interleukin-2 as adjuvant. The phase I trial of TG4001 combined with ave showed a favorable safety profile (Borcoman E. et al, 2023). Methods: Pts with R/M cervical and anogenital cancer and who were checkpoint inhibitors naïve were randomized independent of PD-L1 expression between ave plus TG4001 or ave alone. Pts were required to have no more than one prior line of therapy for R/M disease and no liver involvement. Primary endpoint was PFS. Subgroup analysis (cervical, anal, other genital cancer) was preplanned in the protocol. Results: 90 pts were randomized between June 2021 and April 2024. 49 (54%), 27 (30%) and 14 (16%) pts had cervical, anal, and other genital cancers, respectively. Patients’ demographics were well balanced between the 2 arms. Median PFS (mPFS) was 3.0 and 2.8 months (mo) in the experimental and control arm, respectively (HR=0.87 [90%CI: 0.59-1.29], p=0.28). In the cervical cancer subgroup, mPFS was 4.3 and 2.1 mo in the experimental and control arm, respectively (HR=0.58 [90%CI: 0.33-1.01], p=0.053). Overall Response Rate (ORR) in the whole population was 15.2% (7/46pts) in the experimental arm and 13.6% (6/44pts) in the control arm. In the cervical cancer subgroup ORR was 20% (5/25pts) in the experimental arm and 8.3% (2/24pts) in the control arm. There were no new safety signals. Three pts (6.5%) in the experimental arm and 2 pts (4.5%) in the control arm presented grade 3 or 4 treatment-related AEs. Translational analysis including immunogenicity results will be presented. Conclusions: TG4001 combined with ave did not improve PFS over ave alone in the whole patient population. Preplanned subgroup analysis in cervical cancer showed a positive efficacy signal in the combined arm. Avelumab was provided by the healthcare business of Merck KGaA, Darmstadt, Germany (CrossRef Funder ID: 10.13039/100009945). Clinical trial information: NCT03260023 .

Source

Du trou de poteau à la ville protohistorique : détection, caractérisation et méthodes d'étude de l'habitat de l'âge du Fer entre Garonne et Pyrénées

Type de publi. : Communication dans un congrès
Date de publi. : 27/05/2025
Auteurs : Philippe GardesPierre PéfauThomas Le Dreff

Philippe JEAN-PIERRE

Professeur des universités en sciences de gestion

Lack or excess of autophagy leads to premature leaf senescence probably owing to unbalanced nutrient management

Lack or excess of autophagy leads to premature leaf senescence probably owing to unbalanced nutrient management

Style in Eight Syllables: Metric Annotation and Stylometry of Chrétien de Troyes and Contemporaries

Style in Eight Syllables: Metric Annotation and Stylometry of Chrétien de Troyes and Contemporaries

Large live biomass carbon losses from droughts in the northern temperate ecosystems during 2016-2022

Large live biomass carbon losses from droughts in the northern temperate ecosystems during 2016-2022

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Recommandations pour la prise en charge des pneumonies d’inhalation – Société de Pathologie Infectieuse de Langue Française 2025

Recommandations pour la prise en charge des pneumonies d’inhalation – Société de Pathologie Infectieuse de Langue Française 2025

Clinical features and comorbidities associated with migraine in bipolar disorder: Results from the FACE-BD cohort

Clinical features and comorbidities associated with migraine in bipolar disorder: Results from the FACE-BD cohort

Randomized phase II trial evaluating the combination of TG4001, an HPV16 therapeutic vaccine, and avelumab (ave) in patients (pts) with immunotherapy-naïve recurrent and/or metastatic (R/M) HPV16-positive cervical or anogenital cancer.

Randomized phase II trial evaluating the combination of TG4001, an HPV16 therapeutic vaccine, and avelumab (ave) in patients (pts) with immunotherapy-naïve recurrent and/or metastatic (R/M) HPV16-positive cervical or anogenital cancer.

Du trou de poteau à la ville protohistorique : détection, caractérisation et méthodes d'étude de l'habitat de l'âge du Fer entre Garonne et Pyrénées

Du trou de poteau à la ville protohistorique : détection, caractérisation et méthodes d'étude de l'habitat de l'âge du Fer entre Garonne et Pyrénées