Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 03/03/2026
• Auteurs : Dana Ali Hassan AbdallahIbrahim Jaser AbualrobShreyasi AcharyaGianluca Aglieri RinellaLuca AgliettaNeelima AgrawalZubayer AhammedShakeel AhmadIshaan AhujaZulkaida AkbarValentina AkishinaMohammad Al-TuranyBruno AlessandroJose Ruben Alfaro MolinaBushra AliAndrea AliciJohan AlmeGiacomo AloccoTorsten AltIgor AltsybeevCristian AndreiNicodemos AndreouAnton AndronicMassimo AngelettiVenelin AnguelovFederico AntinoriPietro AntonioliNicole ApadulaHarald AppelshaeuserSilvia ArcelliRoberta ArnaldiIonut Cristian ArseneMesut ArslandokAndre AugustinusRalf Peter AverbeckMohd Danish AzmiHitoshi BabaAkash Raj John BabuAngela BadalaJoonsuk BaeYunseul BaeYongwook BaekXiaozhi BaiRaphaelle Marie BailhacheYoshini BailungRenu BalaAlberto BaldisseriBartosz BalisShubham BangaliaZarina BanooVeronika BarbasovaFrancesco BarileLuca BarioglioMaria BarlouBanajit BarmanGergely Gabor BarnafoldiLee Stuart BarnbyEmilie Martine BarreauValerie Ramillien BarretLeonardo Barreto de Oliveira CamposKlaus BarthEsther BartschNicole BastidGuillaume BatigneDaniel BattistiniBoris BatyunyaLuca BaudinoDibakar BauriJose Luis Bazo AlbaIan Gardner BeardenPascal BechtDebadatta BeheraSwadhin BeheraIouri BelikovValerio Di BellaFrancesca BelliniRene BellwiedLucina Gabriela Espinoza BeltranYael Antonio Vasquez BeltranGyula BencediOussama BenchikhiAdel BensaoulaStefania Maria BeoleAnastasia BerdnikovaLuisa BergmannLorenzo BernardinisLatchezar BetevPartha Pratim BhaduriTushar BhallaAnju BhasinBuddhadeb BhattacharjeeLivio BianchiJaroslav BielcikJana BielcikovaAnte BilandzicAnna BinoyGabor BiroSaikat BiswasMihail Bogdan BlidaruNora BluhmeChristoph BlumeFriederike BockTea BodovaLaszlo BoldizsarMarek BombaraPeter Matthew BondGermano BonomiHerve BorelAlexander BorissovAndres Gerardo Borquez CarcamoElena BottaNaseem BouchharYoussef El Mard BouzianiDiana Catalina BrandiburLars BratrudPeter Braun-MunzingerMarco BregantMichal BrozGiuseppe Eugenio BrunoValentin Dimitrov BuchakchievMatthew Daniel BucklandHenner BueschingStefania BufalinoPaul Alois BuhlerNazar BurmasovEdith Zinhle ButheleziAleksandr BylinkinChristopher Alfred CarrJuan Carlos Cabanillas NorisMaria Fernanda Torres CabreraHelen Louise CainesAlberto CalivaErnesto Calvo VillarJuan Manuel Mejia CamachoPaolo CameriniMaria Teresa CamerlingoFabio de Moraes CanedoStefano CannitoSierra Lisa CantwayMihai CarabasFrancesca CarnesecchiLeopoldo Abranches de CarvalhoJavier Ernesto Castillo CastellanosMatteo CastoldiFabio CatalanoSamuele CattaruzziRebecca CerriIrakli ChakaberiaPritam ChakrabortyJustin Wei Ong ChanSinjini ChandraSylvain ChapelandMarielle ChartierSouvik ChattopadhayMeiyi ChenTiantian ChengMadalin Ilie CherciuCvetan Valeriev CheshkovDavide ChiapparaVasco Miguel Chibante BarrosoDavid Dobrigkeit ChinellatoFabrizio ChinuEmma Sophia ChizzaliJaeyoon ChoSoyeon ChoPeter ChochulaZuzanna Anna ChochulskaPanagiotis ChristakoglouChristian Holm ChristensenPeter ChristiansenTatsuya ChujoBarbara ChytlaMario CiaccoCorrado CicaloGabriele CimadorFederico CindoloFabio Filippo ColamariaDomenico ColellaAngelo ColelliManuel ColocciMatteo ConcasGustavo Conesa BalbastreZaida Conesa del ValleGiacomo ContinJesus Guillermo Contreras NunoMaurice CoquetPietro CorteseMauro Rogerio CosentinoFilippo CostaSusanna CostanzaPhilippe CrochetMaciej Marek CzarnynogaAndrea DaineseElena Dall'OccoGautam DangeMeike Charlotte DanischAndrea DanuAizat DaribayevaProttay DasSupriya DasArchita Rani DashSadhana DashAnnalisa de CaroGiacinto de CataldoJan de CuvelandAlessandro de FalcoDaniele de GruttolaNora de MarcoChiara de MartinSalvatore de PasqualeRohaan DebRaffaele del GrandeLuigi Dello StrittoGeovane Grossi Araujo de SouzaPreeti Dhankher LesserDomenico Di BariMarcello Di CostanzoAntonio Di MauroBenedetto Di RuzzaBatoul DiabYanchun DingJanik DitzelRoberto DiviaUliana DmitrievaAlexandru Florin DobrinBenjamin DonigusLars DopperLukasz Janusz DrzenslaJan Michal DubinskiAndrea DublaPascal DupieuxNatalia DzalaiovaTabea Maria EderRaymond James 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TorresAntonio TrifiroTriloki TrilokiAndrea Sofia TrioloSushanta TripathyTulika TripathyStefano TrogoloVictor TrubnikovWladyslaw Henryk TrzaskaTomasz Piotr TrzcinskiChristina TsolantaRan TuRosario TurrisiTrine Spedstad TveterKjetil UllalandBerkin UlukutluSahil UpadhyayaAntonio UrasMarta UrioniGianluca UsaiMokshi VaidMartin ValaNicolo ValleLennart van DoremalenMarco van LeeuwenCasper Arie van VeenRoelof Jan Gijs van WeeldenDezso VargaZoltan VargaPaola Vargas TorresOton Vazquez DoceOmar Vazquez RuedaGiovanni VecilPaul VeenErmanno VercellinRahul VermaRobert VertesiMarta VerweijLinda VickovicZabulon VilakaziAnna VillaniCornelius Johannes de VilliersTiziano VirgiliMaxim Mikael Olavi VirtaAlexander VodopyanovMartin Andreas VolklSergey VoloshinGiacomo VolpeBarthelemy von HallerIvan VorobyevNikita VozniukJanka VrlakovaJie WanChunzheng WangDongfang WangYiping WangYuanzhe WangYubiao WangZhengqing WangFelix Thomas WeiglhoferSandro Christian WenzelJohannes Peter WesselsPiotr Kazimierz WiacekJens WiechulaJon WikneGrzegorz Andrzej WilkJeremy John WilkinsonGuido Alexander WillemsNicola WilsonBernd Stefan WindelbandJonathan Caspar WitteMaksymilian WojnarCezary Ireneusz WorekJosephina Rae WrightChuntai WuWenya WuYitao WuKegang XiongZhenjun XiongLang XuRan XuZhengwei XueAnkur YadavArun Kumar YadavYorito YamaguchiSeunghwan YangShiming YangSatoshi YanoZhenyu YeEmma Rose YeatsJie YiRuiqi YinZhongbao YinIn Kwon YooJin Hee YoonHyeonjin YuShiming YuanAlperen YuncuValentina ZaccoloChiara ZampolliFederica ZanoneNima ZardoshtiPetr ZavadaBiao ZhangChi ZhangLiuyao ZhangMaolin ZhangMingyu ZhangSong ZhangXiaoming ZhangYifei ZhangYuan ZhangZhen ZhangDaicui ZhouYou ZhouZiqian ZhouJianhui ZhuSenjie ZhuYa ZhuAlessandra ZingarettiStefan Cristi ZugravelNicola Zurlo
• Organismes : Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont

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Résumé : This article presents the first measurement of the (anti)deuteron and antiproton transverse-momentum distributions, the deuteron coalescence parameter, and the ratio between the yields of deuteron and proton in and out of jets in p-Pb collisions at $\sqrt{s_{\rm NN}} = 5.02$ TeV. Three regions are used to study the jet-correlated production: Toward, Away, and Transverse to the jet axis, which direction is approximated by the leading particle in the event with $p_{\rm T}^{\rm lead} > 5$ GeV/$c$. The jet contribution is obtained from the Toward region by subtracting the underlying event, which dominates the Transverse region. In p-Pb collisions, an enhancement of the coalescence parameter $B_{\rm 2}$ is observed in jets compared to the underlying event. The enhancement is larger than the one observed in a similar analysis already in pp collisions. The results are compared with predictions from PYTHIA 8.314 using the Angantyr model with a deuteron production model based on ordinary nuclear reactions. The model is able to qualitatively reproduce the large enhancement of the coalescence parameter in jets with respect to the out-of-jets one. The results are further compared in detail with similar ones from previous studies for pp collisions at $\sqrt{s} = 13$ TeV.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2026
• Auteurs : Emeline BelletGuillemette MénotChristine PiotX. CrostaVincent GrossiMarie-Alexandrine SicreMercedes Mendez-MillanVincent KleinSalomé Ansanay-AlexMatthew MakouJérôme PoulenardEmmanuel MaletBernard FangetEivind StørenNicolas LeviavanAymeric ServettazJostein BakkePhilippe SabatierFabien Arnaud
• Organismes : Environnements, Dynamiques et Territoires de Montagne Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Environnements, Dynamiques et Territoires de Montagne Environnements et Paléoenvironnements OCéaniques Institut méditerranéen d'océanologie Variabilité de l'Océan et de la Glace de mer Variabilité à long terme du climat de l'océan Variabilité de l'Océan et de la Glace de mer Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne University of Bergen Institut Polaire Japan Agency for Marine-Earth Science and Technology University of Bergen Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Institut Ecologie et Environnement - CNRS Ecologie et Environnement Institut national des sciences de l'Univers
• Publié dans Quaternary Science Reviews le 27/10/2020

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Résumé : Climatic variability in the Southern Hemisphere is largely controlled by the latitudinal position of the Southern Hemisphere Westerly Winds (SHW), whose migration influences precipitation, temperature, and Antarctic upwelling. This study presents the results of analyses of two lacustrine sediment cores from Lake Armor, located on the subantarctic Kerguelen Islands (49 • 15′S, 69 • 10′E), within the SHW belt. Lipid biomarkers (Glycerol Dialkyl Glycerol Tetraethers, n-alkanes, and their hydrogen isotopes) were used to reconstruct mean annual air temperature above freezing (MAF) and humidity conditions. These records are compared with a high-resolution diatom-based summer sea surface temperature (SST) reconstruction from marine core MD11-3353, situated 150 km southwest of Lake Armor. In the late glacial and Early Holocene, our results reveal a period of warm air temperature, comparable to current values and very warm sea surface temperature, 5°C above the current values. Around 9000 cal a BP, an abrupt transition occurred, marked by a cooling of 5°C in SST and 1.5°C in MAF, interpreted as a northward migration of the SHW and associated oceanic fronts. The Mid-to-Late Holocene period is characterized by pronounced MAF variability, including a notably warm interval between 3000 and 2000 cal a BP, when n-alkane dD suggests the prevalence of wetter conditions. Since ~250 cal a BP, a southward migration of the SHW has produced a 2.5°C rise in MAF. Our findings are overall consistent with previous studies from the Indian Ocean, but permit us to go a step further as by comparing SSTs and air temperatures. This suggests that SST is not a reliable predictor of air temperature on the Kerguelen Islands, particularly during the Early Holocene. We hence argue that Kerguelen air temperature is predominantly controlled by the position of westerly winds, as an indicator of reorganisations in air mass trajectories.

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Fichiers liés : 2026_Bellet_QSR_Holocene climatic changes in the Kerguelen archipelago.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2026
• Auteurs : Laurence FaivreCamille LevelRégis CoutantPatrice RodienAnne A. BarlierAlexandru SaveanuClaire BouvattierPatricia BretonesLaetitia MartinerieSylvie RossignolCamille LenelleFlorence RoucherC BinquetLaurent PasquierEmeline DavoineColine CormierMarie BournezRaphaelle MaudinasMaxime GonnotAugustin LefevreJulien MaravalHana SafraouYannis DuffourdChristine Bellanné-ChantelotCécile Saint-MartinAnne BergougnouxDelphine MalletJérôme BouligandNicolas de RouxLucie CoppinGwenaëlle DieneChristine PoitouxDelphine PrunierXavier DieuNelly BurnichonSophie Christin-MaitreSylvie JaillardErika LaunayJean-Pierre RabèsPascale BenlianMathilde Di FilippoOriane MarmontelChristine Poitou BernertCorinne VigourouxElise BismuthJacques BeltrandMichel PolakSophie GiraudPascal PignyFrédérique SavagnerIsabelle Olivier PetitJean-Baptiste ArnouxSophie BeliardMarie-Françoise OdouPauline RomanetArnaud MolinAndreea ApetreiNicolas RichardLaurence PacotEric PasmantMarguerite HureauxRosa VargasMathilde Gay-BellileKarine AouchicheAlain CarriéMargaux ChauvetAntonio GalloJulie LemalePhilippe MoulinNoël PerettiChristel Thauvin-RobinetFrédéric HuetVéronique Tardy-Guidolet
• Organismes : Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale CHU d'Angers [Département Urgences] Marseille medical genetics - Centre de génétique médicale de Marseille Institut Marseille Maladies Rares Genétique ENdocrinienne Oncologique et Pharmacogénétique Genétique ENdocrinienne Oncologique et Pharmacogénétique Marseille medical genetics - Centre de génétique médicale de Marseille Physiologie et physiopathologie endocriniennes Hospices Civils de Lyon Physiologie et physiopathologie endocriniennes AP-HP Hôpital universitaire Robert-Debré [Paris] Université Paris Cité Institut de Recherche sur les CERamiques Center for Translational and Molecular medicine [Dijon - UMR1231] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Epidémiologie et recherche clinique en oncologie digestive : EPICAD (CTM UMR 1231) Institut de Génétique et Développement de Rennes Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Center for Translational and Molecular medicine [Dijon - UMR1231] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand FHU TRANSLAD (CHU de Dijon) Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon) Institute for Translational Research in Inflammation - U 1286 Physiologie et physiopathologie endocriniennes Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] AP-HP - Hôpital Antoine Béclère [Clamart] Service de Génétique Moléculaire Pharmacogénétique et Hormonologie [CHU Bicêtre] Biologie, génétique et thérapies ostéoarticulaires et respiratoires Biologie, génétique et thérapies ostéoarticulaires et respiratoires Biologie, génétique et thérapies ostéoarticulaires et respiratoires
• Publié dans Annales d'Endocrinologie = Annals of Endocrinology le 25/10/2020

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Résumé : Introduction: Genome sequencing (GS) is reshaping newborn screening (NBS) by enabling the early detection of a broader range of rare, treatable and/or actionable disorders. In the context of rapid therapeutic advances, international pilot programs-many coordinated within the International Consortium on Newborn Sequencing (ICoNS)-are evaluating genome-based NBS (gNBS) as a preventive public health strategy. Materials and methods: We reviewed published international gNBS pilot studies, with particular attention to discussions related to endocrine disorders. We integrated insights from the French PERIGENOMED-CLINICS 1 (PGC1) project, including its curated gene list and collaboration mainly with the FIRENDO French network dedicated to rare endocrine diseases. Results: No publications were identified specifically addressing gNBS in rare pediatric endocrine diseases as a unified domain. In comparative analyses of gNBS pilot programs, endocrine disorders represented approximately 10% of included conditions, with marked heterogeneity across initiatives and no primary endocrine disorder uniformly retained. Analysis of the PGC1 dataset identified 125 endocrine and endocrine-adjacent gene-disease dyads (14% of all project dyads), divided into list 1 ("treatable", n = 62) and list 2 ("actionable", n = 63). List 1 predominantly included early-onset, hormonally driven disorders, whereas list 2 extended toward obesity-related and multisystem syndromic conditions. Stratification by clinical actionability revealed four categories ranging from time-critical neonatal conditions to surveillance-driven and long-term risk phenotypes, underscoring substantial variability in timing of intervention, penetrance, and level of evidence supporting early benefit. Conclusion: Genomic NBS is transforming rare disease management, including endocrine diseases, by enabling earlier diagnosis, precision care, and coordinated professional and family-based interventions, marking a paradigm shift in population health.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2026
• Auteurs : Rita BitarPhilippe BlumsteinNicolas SoetartPierre CordierMaria-Dolores SanchezBienvenue RazafimandimbyFaraj FajlounJean-Philippe BoucharaJacques GuillotEmmanuel Bensignor
• Organismes : Centre Hospitalier Universitaire Vétérinaire d'Oniris [Nantes] Centre Hospitalier Universitaire Vétérinaire d'Oniris [Nantes] Centre Hospitalier Universitaire Vétérinaire d'Oniris [Nantes] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Centre Hospitalier Universitaire Vétérinaire d'Oniris [Nantes] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques
• Publié dans Journal of Medical Mycology = Journal de Mycologie Médicale le 31/10/2020

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Résumé : This article reports the clinical, diagnostic, and therapeutic aspects of a rare case of cutaneous and subcutaneous scedosporiosis in a 16-year-old domestic cat. The animal presented with a painful, ulcerated nodule at the base of the tail. Histopathology and fungal culture confirmed a pyogranulomatous dermatitis with hyaline hyphae, and molecular analysis identified Scedosporium sphaerospermum, a soil-dwelling fungus newly described. Despite targeted antifungal treatment with itraconazole and topical ciclopirox olamine, the cat developed systemic complications and died. This case emphasizes the challenges associated with diagnosing and managing opportunistic fungal infections in companion animals. It is, to the authors’ knowledge, the first case of infection caused by S. sphaerospermum.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2026
• Auteurs : Delfien J.A. BogaertChristina WolfsbergerAndishe AttarbaschiJonathan GathmannKlaus WarnatzGabriele MuellerAnna MukhinaStephan RuschDalia Abd ElazizSohilla Lofty M. AbdelkaderAvigaelle AbitbolHassan AbolhassaniLalash AbrahimMohamed AbuzakoukPietro Andrea AccardoNabila Achir MoussouniVeronica AfonsoPhilipp AgyemanMartina AhlmannAlessandro AiutiAbla AklGüzide AksuKim AlbersMichael AlbertMeda Diana AlecsandruOlga AleinikovaSvetlana AleshkevichRadwa Salah Eldeen Youssif AlkadyLuis AllendeMickaël AlligonZoe AllwoodManrique de Lara Laia AlsinaDaniela Ambrosch-BarsoumianLisa AmeshoferKenza AmourEvrim AnadolAriharan AnanthachagaranChantal AndriamangaJulia AndrisKarin AndritschkeFederica AngeliniTobias AnkermannKatrin ApelSiamak AramiÖmür ArdenizPeter ArkwrightKarina ArnoldRudolf AscherlNajla AssamNurit Assia-BatzirFaranaz AtschekzeiSybille AumannVolker AumannMagnus AurivilliusBernd AussererTadej AvcinSezin AydemirEmel Aygören-PürsünCagdas AyvazdenizChiara AzzariLo BabacarPerrine BachSophie BachmannPeter BaderShahrzad BakhtiarRenate BancéCatherine BangsKaterina BarfuszSafa BarisB. BarlanisilMichaela BartschLucia Augusta BaselliLaura Batlle-MasoHelge BaumannUlrich BaumannVeronika BaumeisterHelen BaxendaleSuzanne BazenBeatrice BeaurainJulien BeautéMounia Bechar-MakhloufiNorbert BeckBrigitta BeckerChristian BeckerUta BehrendsRenata BeiderRita BeierAmel BelkacemLuisa BelkeSven BellertBernd BelohradskyAouatef Ben-BouzidVincent BenoîtLilia BenslamaThamila Berdous-SahedJan BergilsAnna BerglöfPeter BergmanKatarzyna Bernat-SitarzJolanta BernatonieneEwa BernatowskaBenedikt BernbeckElena BertoliniClaire BethuneKai BeuckmannMalini BholeAnika-Kerstin BiegnerStefan BielackKirsten BienemannArndt BiglAmélie BigorgneMarc BijlNadine BinderMichaela Bitzenhofer-GrüberGeraldine Blanchard RohnerDagmar BlankClaudia BlattmannJulia BlauAudra BlazieneStefan BlazinaMarkéta BloomfieldRoswitha BlumeBarbara BoardmanSebastian BodeJaap-Jan BoelensChristoph BoeseckeDelfien BogaertJohannes BognerNadezda BohynikovaClaire BoothVictoria BordonArndt BorkhardtMelanie BörriesMichael BorteStephan BorteLukas BossallerMadeleine BossardJeannet BotrosSoraya BoucheritJeannette BoutrosOksana BoyarchukOnur BoymanKaan BoztugSara Branco Pereira da SilvaThomas BraschlerSophie BravoRobbert BrediusPhilip BrightCarolina Brito de Azevedo AmaralNicholas BrodszkiGrit BrodtAllan BrolundPauline BrosselinBastian BrummelSonja Brun-SchmidJürgen BrunnerRoswitha BrunsChristina BuchtaDietke BuckAileen BückerMatthew BucklandMartina BührlenStefan BurdachSiobhan BurnsJanet BurtonLuis CaminalCaterina CancriniFabio CandottiClementina CanessaAndrew CantNathan CantoniBrindusa CapilnaFabiola CaracseghiIsabel CaragolJavier CarboneMaria CarrabbaJean-Laurent CasanovaLatanya ChamberlainAnita ChandraChristophe ChantrainHelen ChapelJulie ChassotRonnie CheeMatteo ChinelloCharu ChopraZita ChovancovaMartin ChristmannKrystyna ChrzanowskaPeter CiznarKarlien ClaesCarl Friedrich ClassenMartin ClassenAlexis-Virgil CochinoAlison CondliffeSelim CorbaciogluAna Isabel CordeiroDonatienne Cordier WynarClaire CoreLaurence CostesTanya CoulterVirginie CourteilleMaria CristinaMaria CucuruzLeonik Nel DabrowskaNel Dabrowska LeonikMandy DählingMary Louise DalyClaudia-Sabrina DanielMaria Giovanna DanieliJames DarrochGraham DaviesJavier de Gracia RoldanNarimene de NadaiIris de SchutterNathalie de VergnesEsther de VriesJosine de WitteFrans DebaetsTheo DebertChristiane DeboeckCorina DefilaJudith DeimelDiane DelaplaceRosa Maria DellepianeNelli DellertLaura DellieraAnita DelorUlrike DemelJohn DempsterM.M. den OsRosmarie DenggSora Asfaw DesisaAlexandra DestaDrahomira DetkovaMaite DewerchinRomina Dieli CrimiDagmar DillooFlorentia DimitriouSarah Svenja DingesJasmin DinserNabila DipaniJohannes DirksAnna-Maria DittrichLylia DjermaneYagmur DogruFigen Dogu EsinAngelika DombrowskiJulia Dominguez EscobarMichaela DöringCamilla Heldbjerg DrabeSusann DrerupBarbara DrexelG.J.A. DriessenGregor DückersYasmine DudoitAndrea DuppenthalerGeorg Ebetsberger-DachsMate Barnabas EcserJ. David EdgarMaartje EekmanStephan EhlRosanna EhratEva EislOlov EkwallRabab El HawarySabine El-HelouAisha El-MarsafySarina ElbeSuzanne ElcombeAlia EldashYoussif Alkady Radwa Salah EldeenP.M. EllerbroekRoland EllingJane ElliottAisha ElmarsafyAngelika EngelhardtDiana ErnstFügen ErsoyStefanie EsperIsabel EstevesAmos EtzioniAndrew ExleyMartin FaberGiovanna FabioGaby FahrniLaura Eva FalettiClaire-Michele FarberJoão Farela NevesEmilia FariaHenriette FarkasEvangelia FarmakiMaria FaßhauerAnders FasthGerd FätkenheuerStefanie FaustmannGisela FeckerConleth FeigheryCornelia Feiterna-SperlingPerez Eduardo Fernandez-CruzCordeiro Ferreira ConcaloAlice FersterTobias FeuchtingerOliver FeyenDaniela FinkeAlain FischerSigrid FitterStefan FlaschbergerLucia FleckensteinDirk FöllAdriano FontanaConcetta ForinoElisabeth Förster-WaldlNora FranchetDagmar FreitagUrs FreyHannah Margarete FrickElisabeth FriedelWilhelm FriedrichBarbara FrischLukas FrischknechtStephanie FritzemeyerAlenka GagroManfred GahrNermeen Mouftah GalalEleonora GambineriAgnes GamperFranziska GamsAstrid GanzowNicolas GarcelonTomaz GarcezMarina GarciapratAnn GardulfJanine GaribayBirgit GarwerJonathan GathmannBenjamin GathmannCorinna GebauerLinda GeberzahnTilman GeikowskiUlf GeisenChristiane GemanderAndrew GenneryMarie GerischMichael GernertKatrin GerrerStev GerschmannSujal GhoshCarolin GianniniJuana Gil HerreraNoemi Gimenez SanzMatthias GirndtRamona GirrbachHermann GirschickAntonios GkantarasIoannis GkougkourelasDominika GładyszSusanne GnatowskiElisabeth GnodtkeVera GodaSarah GoddardDaniela GoebelJean-Christophe GoffardSigune GoldackerEva Maria GollowitschManuella GomesMark GompelsMíriam GonzálezLuis Ignacio Gonzalez GranadoPavels GordinsKatharina GößlingLisa GöschlLucy GossensEwelina GowinLea GraafenLeo GracaBrigita Gradauskiene-SitkauskieneDagmar GrafNorbert GrafElliot GrangeH. Anne GrashoffJohann GreilSofia GrigoriadouBodo GrimbacherHelen GronlundUte Groß-WieltschTeresa GuerraKissy Guevara-HoyerMor Seny GueyeNoemie GuibertBirgit GülnurTayfun GüngörMarina GusevaDavid GuzmanMarcel HaagGabriele HaaseHenriette HaenickeFilomeen HaerynckInes HafsaDavid HaginEmine HalitiMichael HallekLennart HammarstroemGonca HanciogluRupert HandgretingerLeif HanitschSusanne HansenTetyana HariyanThomas HarrerPia HassunahMaria HatzistilianouFabian HauckThomas HauserMargje HaverkampGrant HaymanPaul HeathChristian HedrichMaximilian HeegMichael HeikeMartin HeimbrodtSabine HeineUlrich HeiningerChristian HeinrichValerie HeinzAndreas HeitgerMatthew HelbertArthur HelblingCamilla Heldbjerg DrabeAntje HelligeJulya HempelKaren HendersonJörg HenesPhilipp HennekeChristian HennigKarin HenrichsMartin HerbstWalter HermannManuel HernandezAnja HernándezEdyta Heropolitanska-PliszkaRichard HerriotFriedrich HerrmannArchana HerwadkarChristoph HessUrsula HessSebastian HesseSonja HigginsAnna 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KelleherTessa KerreSara Sebnem KilicGerhard KindleMartina KirchnerSimone KiwitAyca KiykimJessica KlasenMaja Klaudel-DreszlerAriane KleinChristoph KleinAndreas Klein-FrankeIlona KleineStefan KleinertChristian KlemannMarion KlimaAdam KlocperkRobin KobbeDilara Fatma Kocacik UygunMelanie KochYvonne KochlerNaschla KohistaniMarina KojicAntonio KoliosUwe KölschSylwia KoltanIrina KondratenkoChristoph KönigsJulia KonoplyannikovaPeter KopacJana KoppDieter KörholzJulia KörholzPauline KorteLarysa KostyuchenkoIna KötterSven KrackerPavlina KrálíckováChristof KrammPhilipp KrammeMáté KrauszWolfhart KreuzJohanna KristaGergely KrivánGabriele KropshoferRenate KrügerOlga KrystufkovaMaria KtistakiJörn-Sven KühlAlexander KühnTaco KuijpersWietse KuisSilke KullmannAndreas KulozikDinakantha KumararatneRia KümmlerAndrea KündgenMagdalena Kurenko-DeptuchCosima KusspaulaNecil KütükcülerCécile Lafoix-MignotBeate LamersPeter LanbeckPaul LandaisSybille Landwehr-KenzelVanessa LangemeyerThorsten LangerPetra LankischNadia LanzManrique de LaraEusebia Lara-VillacanasLisa LaubenthalHans-Jürgen LawsRonan LeahyJae-Yun LeeAndrea LehmannKai LehmbergPatricia LehnerHans LeibfritLeoni LeistnerLoic LemignotPetra LeschSimon LeutnerManolis LiatsisLinda Libai VéghováJohanna LiebelJohannes LieseKotryna LinauskieneRichard LindeMartina LinßnerConrad Ferdinand LippertJiri LitzmanPilar LlobetBabacar LoTariq LodinJindrich LokajDavid LonghinoHilary LonghurstSusana Lopes da SilvaCatharina LorenzenVassilios LougarisDoris LöwAnnelie LubatschofskiMary LucasVerena Lutz-WiegersSabine MaaßMaria Elena MaccariAnna Macura-BiegunVanessa MaerzParaskevi MagginaNizar MahlaouiHannah MahrenholzSarah MaierMounia MakhloufAnne MalfrootLaura MalinauskieneWilma Mannhardt-LaakmannAnia MansonFelicia MantkowskiPetra ManzeyCarolina MarascoNufar Marcus-MandelblitWolfgang MargGasper MarkeljLaszlo MarodiJosé Goncalo MarquesLaura MarquesKarin MarschallNatalia MartínezRafael Martinez de la Ossa Saenz-LopezInmaculada Martinez-SaguerBaldassarre MartireAntonio MarzolloRefiloe MasekelaKatja MasjosthusmannTania Nicole MasmasNuria MatamorosJutta MatternPearl Mau-AsamElizabeth McdermottNichole McintoshKarmen Mesko MeglicRuben MeijerAndrea MeinhardtSafa MeshaalYasmina MessaoudBjörn MeyerDirk Meyer-OlsonIsabelle MeytsRomain MicolBozena MicolocGudrun MielkeCinzia MilitoTomas MilotaSiraj MisbahCarolin MöddenMichael MohrKarina MohrmannMostafa MoinLuis MolinosJana MöllerSarah Möller-NehringHenner MorbachViviana MoscheseOlga MoserDespina MoshousRadoslaw MotkowskiJayashree MotwaniNermeen MouftahgalalCarmen MüglichAnna MukhinaEva MullerChristiane MüllerGabriele MüllerHedi MüllerIngo MüllerThomas MüllerZoe MüllerUlf Müller-LadnerSarah Müller-StöverEsther MünstermannNúria Murtra GarrellMoritz MuschaweckMiriam MutertZohreh NademiParu NaikAndrea NäkeAndrea Martin NaldaGulnara NasrullayevaNora Naumann-BartschVerena NemitzOlaf NethAndreas NeubauerJennifer NeubertCarla NeumannTim NiehuesMara NiemuthAlexandra NietersChris NieuwhofDaniela NolkemperSadia NooraniBudde Adya NoorlanderLuigi NotarangeloGundula NotheisSanam Amelie NowatshGaelle ObengaSuheyla OcakMehmet OkerPeter OlbrichAnna OlipraHeymut OmranPrasad OommenLinda OpitzJaroslava OrosovaSolveig OskarsdottirHülya ÖzsahinMalgorzata PacJana Pachlopnik-SchmidFranco PandolfiEfimia Papadopoulou-AlatakiTheodora PapastamatiouAnna Papatriantafillou-SchmiederAlba Parra-MartinezOlga PaschenkoSrdjan PašićJarek PasnikSmita PatelMartin PavlíkEstela Paz ArtalAnouk PeetersSara Branco Pereira da SilvaRuy Perez-BeckerMarc Perez-GuzmanMartine PergentMarkus PerlhagenHans-Hartmut PeterMarin PetrićMichael PfreundschuhPierre PhilippetCapucine PicardBarbara PietruchaLeonora PietzschClaudio PignataMonica Piquer GibertKerstin PiroltAlessandro PlebaniDaniel PleguezueloKatrin PollokHelena PommereningDaniela PopihnAleksandra PoplonekMarina PoppFulvio PortaJan PortegysKlara Posfay-BarbeJudith PotjewijdSebastian PoulheimSeraina PraderPetra Prämassing-ScherzerMartina PrelogJohan PrevotArthur PriceTimothy PriceMarijke ProesmansJohan ProvotFederica PulvirentiIsabella QuintiAnna RaabAnita RackStefan RaffacEduardo Ramos OviedoPhilippe RandrianomenjanaharyAnja RanohavimparanyMaria RaptakiRoonaka RashidzadehMargit RathwallnerShereen RedaNahida RedouaneFrederico RegateiroJanine ReichenbachBianca ReimersCornelia ReinhardtDirk ReinhardtAnne ReinprechtTamara ReißIsmail ReisliEleonore RennerNima RezaeiAlex RichterDarko RichterNikolaus Peter RieberNadja RieckehrMarion RiedelHeidi RiescherJohannes RischewskiNicole RistlHenrike RitterbuschTanja RitzFrancois RivierJacques RivierePeter RobinsonJürgen RockstrohJoachim RoeslerHimatur RofiahElizabeth RogersonElisabeth RolfesBeate RollerYaryna RomanyshynRoberto RondelliFien RoosensAngela Rösen-WolffValentina RöslerJohannes RothTobias RothoeftAgathe RoubertieGesa RübsamStephan RuschAbraham RutgersPaul RyanGudrun SachKambis SadeghiUlrike SahrbacherAngelika SaidiÖzden Sanal TezcanSilvia Sanchez-RamonJuan Luis SantosRavishankar SargurIhor SavchakSinisa SavicBernhard SchaafMarzena SchaeferChristina SchäfeEva ScharbatkeEllen SchatorjeUwe SchauerCarmen ScheibenbogenRaphael ScheibleClemens ScheineckerRomana SchillerBeatrice SchillingFreimut SchillingSteffi SchliebenThilo SchmalbachMarc Thomas SchmalzingPirmin SchmidNadine SchmidtReinhold Ernst SchmidtMonika SchmitzDominik SchneiderDominik SchneiderReinhard SchneppenheimCathy ScholtesE.H. SchölvinckStefan SchönbergerStefan SchreiberRik SchrijversAndrea SchrollSimone SchruhlJohanna SchrumRalf SchubertCatharina SchuetzSebastian SchuhAnsgar SchulzClaudia SchulzIlka SchulzeHendrik Schulze-KoopsUlf Schulze-SturmEva-Maria SchumacherElvira SchürmannGesine SchürmannVolker SchusterEva SchwaneckKlaus SchwarzTobias SchwarzCarolynne Schwarze-ZanderLothar SchweigererAnna SedivaJörg SeebachReinhard SegerFlorian SegererMarkus SeidelBarbara SelleSuranjith SeneviratneMikko SeppänenHatidje ShabanajSvetlana SharapovaAnna ShcherbinaBenjamin ShillitoeAnne SiepelmeyerKathrin SiepermannAnna SimonArne SimonKatja Simon-KlingensteinMarija SimonovicMerlin Simsen-BarataultElena SindramAlla SkapenkoMaiken SkarkeMalgorzata Skomska-PawliszakMary SlatterJulie SmetC.I. Edvard SmithAli SobhBettina SobikGeorgios SogkasMichael SohmXavier SolanichXavier Solanich-MorenoPere Soler PalacínFranz SollingerRaz SomechAnja SonnenscheinAnnarosa SoresinaMarijke SornsakrinStavrieta SouraSabrina SpaccarotellaGuiseppe SpadaroMonika Sparber-SauerChristof SpeckerCarsten SpeckmannLisa SpeidelMatthaios SpeletasKlaus-Daniel StachelCatherine StadonAurélie StanislasCynthia StapornwongkulPaulina StausRegina SteckCathal SteeleHerbert SteffinUrs SteinerSandra SteinmannWim StevensMartina StiefelSarah StiegerSophie StiehlerHermann StimmSilvia StojanovMatthias StollDominique Stoppa-LyonnetTobias StrapatsasGabriele StraußMonika StreiterRiet Strik-AlbersGaby StrotmannHéctor SuárezcasadoJose Luis SubizaMikael SundinBirgit SüßFabienne SutterAnna SzaflarskaMonika SzemkusHannah TamarySofia TantouMichael TarziHelga TaschnerUlf TedgardCarla TeixeiraR.J.M. Ten BergeKlaus TenbrockSabine TesterIlhan TezcanSonja ThalguterJulian ThalhammerKatharina ThomaMoira ThomasFabian ThomczykVojtech ThonAdrian ThrasherPatricia TierneyNadine TietschAlberto TommasiniBeate TönnesHans-Peter TonyMaria TrachanaCarmen TrappLourdes TricasMaria Conceicao Trindade NevesJordis TrischlerHugo UbietoAnett UelzenAnnette UhlmannJan UllrichKurt UllrichEkrem ÜnalGerhard UrbanskiSimon UrschelAleksandra UszynskaAngelo VaccaN.N. VaganovDaniel VagedesStefanie ValicevicFlorence VallelianRachel van BeemCharlotte van DammeAnnick van de VenJ. Merlijn van den BergMichiel van der FlierJ.T. van DisselP.M. van HagenJ.M. van MontfransGeoffrey van OgtropJacqui van RensChristel A.M.P. van RielAnnet van Royen-KerkhofG.Th.J. van WellAntari VasilikiSirje VelbriJo VenckenAlessandro VenturaFrançois VermeulenChristiane VermylenDorothee ViemannAnja ViereckAnna VillaJeroen VinckeLisa Vinnemeier-LaubenthalKim Duy Vo ThiMirjam VoellerKristina VollbachAlla VolokhaHorst von BernuthPhilipp von BismarckRebecca VossSandra VoßYüksel VuralHeike WachugaNorbert WagnerPer WagströmMatthias WahleVolker WahnNadine WappKlaus WarnatzMonika WarnekeAdilia WarrisJan-Christian WasmuthJean-Blaise WasserfallenAngela WawerManfred WeberCorrie M.R. WeemaesLisa WegeJulius WehrleStephan WeidingerMichael WeißElisabeth Weißbarth-RiedelAntje WernerSara WesselMarco WestkemperMonika WicherLutz WickmannSabine WiegertMonique WieheKatharina WiehlerLydia WiesböckEwa Wiesik-SzewczykAnthony WilliamsBeate WinklerChristel WinklerMartina WinklerMelanie WinklerUwe WintergerstLukas WisgrillTorsten WitteHelmut WittkowskiBarbara WolfSandra WölkeChristina WolschnerBeata Wolska-KusnierzPhilip WoodSarita WorkmanAusten WorthMichaela WortmannWalter Alfred WuilleminNico WulffraatKatharina WustrauChloé Wyndham-ThomasOlcay YeginAlisan YildiranDenise YilmazPatrick YoungEsra YucelMilica ZečevićErić ŽelimirFred ZeppKlaus ZetzscheRainald ZeunerStefan ZielenMartina ZimmermannGerhard KindleJoris van MontfransMarkus Seidel
• Organismes : Saint Anna Children's Hospital [Vienne] = St Anna Kinderspital Albert-Ludwigs-Universität Freiburg = University of Freiburg Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, Germany. Karolinska University Hospital [Stockholm] Children’s Medical Center [Tehran, Liban] Universitätsklinikum Münster Klinik für Kinder [Münster, Germany] IRCCS San Raffaele Scientific Institute [Milan, Italie] San Raffaele Telethon Institute for Gene Therapy [Milan, Italy] Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2026
• Auteurs : Giulia TammamAbderhmane SliouiDiane FriedmanBlandine AcketMichele CavalliSaskia BreschEmmeline LagrangeGuilhem SoleJean-Baptiste NouryLuce Barbat Du CloselClémence MaroisAleksandra Nadaj PaklezaCéline TardEmmanuelle Salort-CampanaPhilippe-Edouard MerleDjillali AnnaneShahram AttarianFanny DuvalSimon FrachetJuliette SvahnAntoine PegatFrançoise BouhourGuillaume TaiebJulien PralineAngela PumaVincent FabryLuisa VillaStéphane BeltranAnthony BehinPascal CintasSabrina Sacconi
• Organismes : Hôpital Pasteur [Nice] Hôpital Pasteur [Nice] Hôpital Raymond Poincaré [AP-HP] Université de Versailles Saint-Quentin-en-Yvelines Université Paris-Saclay Département Neurologie [CHU Toulouse] Hôpital Pasteur [Nice] Hôpital Pasteur [Nice] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Filière Neuromusculaire CHU de Bordeaux Pellegrin [Bordeaux] ERN EURO-NMD – European Reference Network for Rare Neuromuscular Diseases Centre Hospitalier Régional Universitaire de Brest Lymphocytes B, Autoimmunité et Immunothérapies Filière Neuromusculaire Hôpital de la Timone [CHU - APHM] Filière Neuromusculaire CHU Pitié-Salpêtrière [AP-HP] Lille Neurosciences & Cognition - U 1172 Département de neurologie [Lille] Filière Neuromusculaire Hôpital de la Timone [CHU - APHM] Neurologie [CHU Amiens] Hôpital Raymond Poincaré [AP-HP] Université de Versailles Saint-Quentin-en-Yvelines Université Paris-Saclay Hôpital de la Timone [CHU - APHM] Filière Neuromusculaire Filière Neuromusculaire CHU de Bordeaux Pellegrin [Bordeaux] ERN EURO-NMD – European Reference Network for Rare Neuromuscular Diseases Neuropathies et Innovations Thérapeutiques Service de Neurologie [CHU Limoges] Filière Neuromusculaire Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Institut de Génomique Fonctionnelle Centre Hospitalier Universitaire d'Orléans Hôpital Pasteur [Nice] Filière Neuromusculaire Département Neurologie [CHU Toulouse] Hôpital Pasteur [Nice] Centre Hospitalier Régional Universitaire de Tours Filière Neuromusculaire CHU Pitié-Salpêtrière [AP-HP] Filière Neuromusculaire Département Neurologie [CHU Toulouse] Hôpital Pasteur [Nice] Institut de Recherche sur le Cancer et le Vieillissement
• Publié dans Journal of Neuromuscular Diseases le 26/10/2020

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Résumé : ObjectivesTo evaluate the effectiveness and safety of zilucoplan in the real-world treatment setting in France.MethodsThis retrospective cohort study evaluated patients with generalized anti-AChR myasthenia gravis (MG) failing current therapy enrolled in the French early access program (EAP) for zilucoplan. Patients were evaluated at enrollment and at Months 1, 3 and 6 with the MG-ADL score, the Myasthenic Muscle Score (MMS-Garches), and the MG-quality of life questionnaire (MG-QoL15r). MG crises and on-treatment adverse events were documented. MG medication use was compared between the six months before and after enrollment.ResultsForty-eight patients were enrolled and treated with zilucoplan (mean age: 56.2 years; 50.9% men). Thirty patients achieved six months follow-up before the EAP ended. Three patients discontinued zilucoplan due to lack of efficacy. Mean MG-ADL score decreased from 7.4 ± 4.4 to M0 to 2.5 ± 2.7 at M6 (p < 0.0001). 9/43 patients achieved minimal symptom expression at M3 and 12/30 at M6. Mean MMS-Garches score was 67.5 ± 20.0 at M0 and 87.5 ± 13.2 at M6 (p < 0.0001). Mean MG-QoL15r score was 18.2 ± 8.6 at M0 and 8.7 ± 8.3 at M6 (p = 0.0156). 15 patients experienced adverse events, leading to discontinuation in four cases. The mean oral corticosteroid dose decreased from 28.8 ± 11.8 mg to 17.9 ± 11.8 (p = 0.001). Six patients experienced MG crises on treatment, compared to 22 in the six months preceding enrollment. treatment.DiscussionFollowing initiation of zilucoplan treatment, we observed an improvement in MG symptoms and a reduction in MG crises and in exposure to oral corticosteroids. Overall, zilucoplan was well-tolerated with no major adverse events reported.Trial registration informationThe study was registered in the clinicaltrials.gov trial registry under the number NCT06815133 (https://clinicaltrials.gov/study/NCT06815133) on February 4th, 2025.

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Fichiers liés : Tammam et al 2026.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2026
• Auteurs : Matthieu AllezMichiel T.J. BakSofia BrandLaura Diebakate-ScordamagliaElisabeth CapellePhilippe SeksikStéphane NanceyJean-Marc GornetAnthony BuissonFranck CarbonnelLaurent Peyrin‐BirouletEdouard LouisXavier HébuterneMélanie SerreroArnaud BourreilleXavier TretonPauline WilsMathurin FumeryPierre BlancMathieu UzzanHarry SokolNicolas BarnichJulien KirchgesnerJean-Frédéric ColombelLéon MaggioriMadeleine BezaultMark SilverbergAnnemarie de VriesJérome LambertNassim Hammoudi
• Organismes : Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] Research Institute of the McGill University Health Centre Institut de Recherche Saint Louis Erasmus University Medical Center [Rotterdam] Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) Research Institute of the McGill University Health Centre Research Institute of the McGill University Health Centre CHU Saint-Antoine [AP-HP] Centre de Recherche Saint-Antoine Gut,Liver & Microbiome Research FHU Centre International de Recherche en Infectiologie Hopital Saint-Louis [AP-HP] Université Clermont Auvergne Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Nutrition-Génétique et Exposition aux Risques Environnementaux Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Liège Centre Hospitalier Universitaire de Nice Hôpital Nord [CHU - APHM] Aix Marseille Université The Enteric Nervous System in gut and brain disorders [U1235] Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Hôpital Claude Huriez [Lille] Institute for Translational Research in Inflammation - U 1286 Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Henri Mondor Centre de Recherche Saint-Antoine Gut,Liver & Microbiome Research FHU Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Pharmacoépidémiologie et évaluation des soins [iPLesp] Centre de Recherche Saint-Antoine Gut,Liver & Microbiome Research FHU Icahn School of Medicine at Mount Sinai [New York] Hopital Saint-Louis [AP-HP] Research Institute of the McGill University Health Centre University of Toronto Erasmus University Medical Center [Rotterdam] Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) Research Institute of the McGill University Health Centre Institut de Recherche Saint Louis
• Publié dans Clinical Gastroenterology and Hepatology le 30/10/2020

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Résumé : Background: Ileocolonic resection remains common in Crohn's disease (CD) despite increasing biologic use. Aims: to identify risk factors for postoperative recurrence and to assess prophylactic biologic therapy effectiveness in relation to risk factors. Methods: This prospective multicentre study included adults with CD undergoing ileocolonic resection (ICR). The primary endpoint was endoscopic recurrence (modified Rutgeerts Score ≥i2b) within the year following surgery. Factors associated with endoscopic recurrence were identified using a logistic regression model. A composite time-to-event endpoint was defined for long-term follow-up based on clinical, endoscopic and/or imaging data. An external validation of our predictive model was performed in two independent international cohorts. Results: Among 632 patients (median disease duration 7.8 years), 78% had prior biologic exposure; 44% received postoperative biologic prophylaxis. Endoscopic recurrence occurred in 237 (37.5%) patients. In multivariable model, risk factors included: male sex (OR 1.97 (95%CI: 1.38, 2.83), active smoking (OR 2.37 (95%CI: 1.56, 3.62), previous ICR (OR 1.78 (95%CI: 1.13, 2.82), previous exposure to one (OR 2.15 (95%CI: 1.37, 3.42) or more than one biologic (OR 2.41 (95%CI: 1.39, 4.22). Biologic prophylaxis significantly reduced recurrence risk (OR 0.31 (95%CI: 0.20, 0.45), independently of these risk factors. A predictive nomogram based on multivariable analysis achieved an AUC of 0.72, with similar performance in external cohorts. Clinically significant recurrence, observed in 22.9%, 36.5% and 53.2% at 3, 5 and 10 years, was associated with severity of early endoscopic recurrence. Conclusion: Postoperative recurrence risk can be estimated using a model based on clinical factors. Biologic prophylaxis is highly effective in preventing early endoscopic recurrence, regardless of risk profile.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 26/02/2026
• Auteurs : Dana Ali Hassan AbdallahIbrahim Jaser AbualrobShreyasi AcharyaKshitij AgarwalGianluca Aglieri RinellaLuca AgliettaNeelima AgrawalZubayer AhammedShakeel AhmadIshaan AhujaZulkaida AkbarValentina AkishinaMohammad Al-TuranyBruno AlessandroJose Ruben Alfaro MolinaBushra AliAndrea AliciJohan AlmeGiacomo AloccoTorsten AltIgor AltsybeevCristian AndreiNicodemos AndreouAnton AndronicMassimo AngelettiVenelin AnguelovFederico AntinoriPietro AntonioliNicole ApadulaHarald AppelshaeuserSilvia ArcelliRoberta ArnaldiIonut Cristian ArseneMesut ArslandokAndre AugustinusRalf Peter AverbeckMohd Danish AzmiHitoshi BabaAkash Raj John BabuAngela BadalaJoonsuk BaeYunseul BaeYongwook BaekXiaozhi BaiRaphaelle Marie BailhacheYoshini BailungRenu BalaAlberto BaldisseriBartosz BalisShubham BangaliaZarina BanooVeronika BarbasovaFrancesco BarileLuca BarioglioMaria BarlouBanajit BarmanGergely Gabor BarnafoldiLee Stuart BarnbyEmilie Martine BarreauValerie Ramillien BarretLeonardo Barreto de Oliveira CamposKlaus BarthEsther BartschNicole BastidGuillaume BatigneDaniel BattistiniBoris BatyunyaLuca BaudinoDibakar BauriJose Luis Bazo AlbaIan Gardner BeardenPascal BechtDebadatta BeheraSwadhin BeheraIouri BelikovValerio Di BellaFrancesca BelliniRene BellwiedLucina Gabriela Espinoza BeltranYael Antonio Vasquez BeltranGyula BencediOussama BenchikhiAdel BensaoulaStefania Maria BeoleAnastasia BerdnikovaLuisa BergmannLorenzo BernardinisLatchezar BetevPartha Pratim BhaduriTushar BhallaAnju BhasinBuddhadeb BhattacharjeeLivio BianchiJaroslav BielcikJana BielcikovaAnte BilandzicAnna BinoyGabor BiroSaikat BiswasMihail Bogdan BlidaruNora BluhmeChristoph BlumeFriederike BockTea BodovaLaszlo BoldizsarMarek BombaraPeter Matthew BondGermano BonomiHerve BorelAlexander BorissovAndres Gerardo Borquez CarcamoElena BottaNaseem BouchharYoussef El Mard BouzianiDiana Catalina BrandiburLars BratrudPeter Braun-MunzingerMarco BregantMichal BrozGiuseppe Eugenio BrunoValentin Dimitrov BuchakchievMatthew Daniel BucklandHenner BueschingStefania BufalinoPaul Alois BuhlerNazar BurmasovEdith Zinhle ButheleziAleksandr BylinkinChristopher Alfred CarrJuan Carlos Cabanillas NorisMaria Fernanda Torres CabreraHelen Louise CainesAlberto CalivaErnesto Calvo VillarJuan Manuel Mejia CamachoPaolo CameriniMaria Teresa CamerlingoFabio de Moraes CanedoStefano CannitoSierra Lisa CantwayMihai CarabasFrancesca CarnesecchiLeopoldo Abranches de CarvalhoJavier Ernesto Castillo CastellanosMatteo CastoldiFabio CatalanoSamuele CattaruzziRebecca CerriIrakli ChakaberiaPritam ChakrabortyJustin Wei Ong ChanSinjini ChandraSylvain ChapelandMarielle ChartierSouvik ChattopadhayMeiyi ChenTiantian ChengMadalin Ilie CherciuCvetan Valeriev CheshkovDavide ChiapparaVasco Miguel Chibante BarrosoDavid Dobrigkeit ChinellatoFabrizio ChinuEmma Sophia ChizzaliJaeyoon ChoSoyeon ChoPeter ChochulaZuzanna Anna ChochulskaPanagiotis ChristakoglouPeter ChristiansenTatsuya ChujoBarbara ChytlaMario CiaccoCorrado CicaloGabriele CimadorFederico CindoloFabio Filippo ColamariaDomenico ColellaAngelo ColelliManuel ColocciMatteo ConcasGustavo Conesa BalbastreZaida Conesa del ValleGiacomo ContinJesus Guillermo Contreras NunoMaurice CoquetPietro CorteseMauro Rogerio CosentinoFilippo CostaSusanna CostanzaPhilippe CrochetMaciej Marek CzarnynogaAndrea DaineseElena Dall'OccoGautam DangeMeike Charlotte DanischAndrea DanuAizat DaribayevaProttay DasSupriya DasArchita Rani DashSadhana DashAnnalisa de CaroGiacinto de CataldoJan de CuvelandAlessandro de FalcoDaniele de GruttolaNora de MarcoChiara de MartinSalvatore de PasqualeRohaan DebRaffaele del GrandeLuigi Dello StrittoGeovane Grossi Araujo de SouzaPreeti Dhankher LesserDomenico Di BariMarcello Di CostanzoAntonio Di MauroBenedetto Di RuzzaBatoul DiabYanchun DingJanik DitzelRoberto DiviaUliana DmitrievaAlexandru Florin DobrinBenjamin DonigusLars DopperLukasz Janusz DrzenslaJan Michal DubinskiAndrea DublaPascal DupieuxNatalia DzalaiovaTabea Maria EderRaymond James EhlersFlorian EisenhutRen EjimaDomenico EliaBarbara Ewa ErazmusFrancesca ErcolessiBruno EspagnonGiulio EulisseDavid EvansLaura FabbiettiGaia FabbriMattia FagginJulien FaivreWenqing FanTao FangAlessandra FantoniAlessandro FelicielloWenhui FengArturo Fernandez TellezBamina FernandoLucas Ferrandi de OliveiraAndrea FerreroChiara FerreroAlessandro FerrettiDmitry FinogeevFiorella FiondaAmanda Nicole FloresSiegfried Valentin FoertschIlya FokinUmberto FolloRobert ForynskiEnrico FragiacomoHenrik FribertUlrich FuchsDavide FulignoNicola FunicelloChristophe FurgetArtur FursTakahiro FusayasuJens Joergen GaardhoejeMartino GagliardiAlberto Martin Gago MedinaTanu GahlautCarlos Duarte GalvanSarjeeta GamiJose Maria Garabatos CuadradoJosue Martinez GarciaEdmundo Javier Garcia-SolisSara GarettiCorrado GargiuloPiotr Jan GasikAmrit GautamMaria Beatriz de Leone GayMarie GermainRoman August GernhaeuserMarco GiacaloneGiulia GioachinSourav Kanti GiriPaolo GiubellinoPiero GiubilatoPeter GlasselEwa GlimosMaria Gabriela Ferreira Siqueira Amaral GomesLaura GonellaVictor Luis Gonzalez SebastianMarek Boguslaw GorgonKangkan GoswamiSven GotovacVarlen GrabskiLukasz Kamil GraczykowskiEkaterina GreckaAlessandro GrelliCostin GrigorasSmbat GrigoryanOla Slettevoll GroettvikMalte GronbeckFabrizio GrosaSimon Gross-BoltingJan Fiete Grosse-OetringhausRaffaele GrossoDavid GrundNadine Alice GruenwaldRachid GuernaneMaxime Rene Joseph GuilbaudKristjan Herlache GulbrandsenJesper Jan Walter Karlsson GumprechtTuba GundemTaku GunjiJiacheng GuoWenda GuoAnik GuptaRamni GuptaRashi GuptaKatarzyna GwizdzielLaszlo GyulaiTakashi HachiyaCynthia Marie HadjidakisFakhar Ul HaiderSara HaidlovaMintu HaldarWooseok HamHideki HamagakiYounghoon HanRyan Patrick HanniganJoachim HansenJohn William HarrisAustin Vincent HartonMichael Volker HartungAfrina HasanHadi HassanDespina HatzifotiadouPhilip HauerLaura Brittany HavenerErnst HellbarHaavard HelstrupMarvin HemmerSabrina Gabrielle HernandezGerardo Antonio Herrera CorralKristin Fanebust HetlandBenedict HeybeckHartmut HillemannsBoris HippolyteIsis Pihn Marie HobusFelix Willi HoffmannBas HofmanYounghoo HongAdrian HorzykYongzhen HouPeter Zahariev HristovLaura Maria HuhtaThomas HumanicVendulka HumlovaMarko HusarAlek HutsonDirk HutterMinyoung Chris HwangMotoi InabaArtem IsakovTommaso IsidoriMd Samsul IslamMarian IvanovMarian IvanovKaare Endrup IversenJungeol KimMiroslaw Rafal JablonskiBarbara JacakNicolo JacazioPeter Martin JacobsAnna JadlovskaSlavka JadlovskaSyaefudin JaelaniCristiane Jahnke Fiorini da SilvaMonika Joanna JakubowskaErnest JamroDiana Maria JanikMalgorzata Anna JanikSu-Jeong JiYuanjing JiShihai JiaTao JiangAlom Antonio Paz JimenezShangtai JinFlorian JonasDaniel Matthew JonesJohn JowettJerome JungMichael JungAntoine Jean-Simon JuniqueJakub JurackaJetnipit KaewjaiAnouk Ilka Paulina KaiserPeter KalinakAlexander Philipp KalweitAyben Karasu UysalNikolaos KaratzenisTatiana KaravichevaMaja Jadwiga KarwowskaVarchaswi KashyapMarkus KeilBernhard Franz KetzerJohannes KeulSwapnesh Santosh KhadeArvind KhuntiaZhanna KhuranovaBjarte Wang-KilengBeomkyu KimDong Jo KimDongguk KimEun Joo KimGiyeong KimHyunwoo KimJaehyun KimJiyoung KimJunlee KimMinjung KimSe Yong KimTaejun KimJulius Thomas KinnerIvan KiselAdam Ryszard KisielJennifer Lynn KlayJochen KleinSpencer Robert KleinChristian Klein-BoesingMatthias KleinerAlexander KlugeMorgan Bailey KnueselChinorat KobdajRyotaro KoharaAndrey KondratyevJoshua Leon KonigPiotr Jan KonopkaGeorgui Kornakov VanMaximilian KorwieserCornelia KosterArtem KotliarovNino KovacicMarek KowalskiVenelin Valeriev KozhuharovGrigory KozlovIvan KralikAdela KravcakovaMarta Adamina SailerLubos KrcalFilip KrizekKatarina Krizkova GajdosovaCristiano KrugMario KrugerEvgeny KryshenVit KuceraChristian Claude KuhnDeekshit KumarLokesh KumarNavneet KumarShyam KumarSourav KunduMenghsiu KuoPodist KurashviliShunsuke KuritaSvetlana KushpilAndrey KuznetsovMin Jung KweonYoungil KwonSarah Louise La PointePaola La RoccaAnantachai LakrathokStanislas LambertAimeric Robin LandouRune LangoyPavel LarionovElisa LaudiLukas LautnerRafael Angel Narcio LaveagaRoman LavickaRamona LeaJasmin Barbara LebertHyungjun LeeSeungju LeeIosif-Charles LegrandGauthier LegrasAlexian Marc LejeuneTomasz Marcin LelekIldefonso Leon MonzonMarcel Markus LeschPeter LevaiMingze LiPeiyu LiXiaomei LiBeatrice Eva Liang-GilmanJorgen Andre LienRoman LietavaIris LikmetaBong-Hwi LimHyunji LimSanghoon LimYuri Do Nascimento LimaShoulong LinVolker LindenstruthChristian LippmannDominika LiskovaDonghai LiuJian LiuYunfan LiuGianni Shigeru Setoue LiveraroIngrid Mckibben LofnesConstantinos LoizidesSandor LokosJohanna LomkerXavier Bernard LopezErnesto Lopez TorresClement LotteauPengzhong LuWeijian LuZhiyong LuOleksii LubynetsGiorgio Alberto LuciaFabiola Viridiana Lugo PorrasJiaqi LuoGrazia LuparelloJan Michael FriedrichYugang MaVojtech MachacekMagnus MagerMaximilian MahleinAntonin MaireEmilia Maria MajerzMartin Vasilev MakarievGiovanni MalfattoreNasir Mehdi MalikNida MalikDukhishyam MallickNeelkamal MallickGiuseppe MandaglioSubhadeep MandalSushobhan Kumar MandalAlexandru ManeaRafael Stefan ManhartAyan Kumar MannaFranck MansoGeorgios MantzaridisVito ManzariYaxian MaoRobert Waclaw MarcjanGiacomo Vito MargagliottiAnselmo MargottiAna Maria MarinChristina MarkertPaolo MartinengoMario Ivan Martinez HernandezMaria Paula Martins PalharesSilvia MasciocchiMassimo MaseraAlberto MasoniLaure Marie MassacrierOlaf MassenAnnalisa MastroserioLorenzo MatteiSerena MattiazzoAdam Tomasz MatyjaJonathan Lozano MayoFrancesco MazzaschiMarianna MazzilliYury MelikyanMaria Monalisa de Melo PaulinoArturo Alejandro Menchaca-RochaJesus Eduardo Munoz MendezElisa MeninnoMarius Wilm MenzelMichal MeresLuca MichelettiDarius MihaiDimitar Lubomirov MihaylovAndreas Ulveseth MikalsenKonstantin MikhaylovLouise MillotNicola MinafraDariusz Czeslaw MiskowiecAbhi ModakBedangadas MohantyMohammed Mohisin KhanMikael Andreas MolanderMriganka Mouli MondalShirajum MoniraDenise Aparecida Moreira de Godoy WillemsAndreas MorschCristian MoscatelliTeo MrnjavacStefanie MrozinskiValeria MucciforaSanjib MuhuriAlice MulliriMarcelo Gameiro MunhozRobert Helmut MunzerLuciano MusaJan MusinskyJulian Wojciech MyrchaBharati NaikAnjali Ila NambrathBasanta Kumar NandiRosario NaniaEugenio NappiAdrian Fereydon NassirpourVlad-Iulius NastaseAbhishek NathNina Francesca NathansonAlexandra NeaguLukas NellenRoman NepeivodaSigurd NeseNicola NicassioBorge Svane NielsenEmil Gorm Dahlbaek NielsenFrancesco NoferiniSeoyoung NohPetr NomokonovJaime NormanNorbert NovitzkyJoakim Ingemar NystrandMatthew Robert OckletonMasanori OginoJongho OhSaehanseul OhAlice Elisabeth OhlsonMasahiro OidaLuca Aguiar de OliveiraChiara OppedisanoAntonio Ortiz VelasquezHiroki OsanaiJacek Tomasz OtwinowskiMotomi OyaKen OyamaSonali PadhanDavide PaganoValerio PagliarinoGuy PaicAntonio PalascianoIaroslav PanasenkoPravata PanigrahiCaterina PantouvakisHanseo ParkJonghan ParkSangwoo ParkTae Yong ParkJasper Elias ParkkilaPreet Bhanjan PatiYash PatleyRajendra Nath PatraJyoti PatterBiswarup PaulFilip PazdicHua PeiThomas PeitzmannXinye PengStefania PerciballiGuillermo Mesa PerezMihai PetroviciStefano PianoMiroslav PiknaPhilippe PillotOmbretta PinazzaChiara PintoSilvia PisanoMateusz Andrzej PloskonAlicja PlachtaMirko PlaninicDamian Kacper PlociennikStefano PolitanoNikola PoljakAmalia PopSarah Julie PorteboeufJakobus Stephanus PotgieterIrandheny Yoval PozosKshitish Kumar PradhanSidharth Kumar PrasadSuraj PrasadRoberto PreghenellaFrancesco PrinoClaude Andre PruneauMaximiliano PuccioSara PucilloSzymon Mateusz PulawskiLuca QuagliaAswathy Menon Kavumpadikkal RadhakrishnanSimone RagoniAnanya RaiAndry Malala RakotozafindrabeNiveditha RamasubramanianLuciano RamelloCesar Omar Ramirez AlvarezMarika RasaSami Sakari RasanenRutuparna RathMax Philip RauchIvan RavasengaMarta RazzaKenneth Francis ReadChristian ReckziegelAndreas Ralph RedelbachKrzysztof RedlichCarolina Anna JauchHector David Regules MedelAttiq Ur RehmanFelix ReidtHaakon Andre Reme-NessKlaus Johannes ReygersMatthias Rudolph RichterAnton Albert RiedelWerner RieglerAndrea Giovanni RifferoMichele RignaneseCristina RipoliCatalin-Lucian RisteaManuel Viqueira RodriguezMario Rodriguez CahuantziKetil RoeedElena RogochayaDavid Michael RohrDieter RoehrichSolangel Rojas TorresPrzemyslaw Stefan RokitaGleb RomanenkoFederico RonchettiDiana Rosales HerreraEdgar Dominguez RosasKrystian RoslonAndrea RossiAnkhi RoyAvisek RoySubhadeep RoyNicola RubiniOmama RubzaJustus Arne RudolphDaniela RuggianoRinaldo RuiPawel Grzegorz RussekAnar RustamovAndrzej Krzysztof RybickiLevi Colt van RyderGeonmo RyuJaehyeok RyuWioleta RzesaBianca SabiuRita SadekSamrangy SadhuArkaprabha SahaSwati SahaBhagyarathi SahooRaghunath SahooDushmanta SahuPradip Kumar SahuJogender SainiShingo SakaiSanjeev Singh SambyalDaniel SamitzIsabella SannaDebojit SarkarValerio SarritzuValentina Mantovani SartiMike SasUmberto SavinoSawan SawanEugenio ScapparoneJohann Joachim SchambachHorst Sebastian ScheidClaudiu Cornel 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• Organismes : Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont

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Résumé : The latest experimental studies related to the search for the Chiral Magnetic Effect (CME) in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 5.02$ TeV recorded with the ALICE detector at the Large Hadron Collider (LHC) are presented. Charge-dependent two-particle correlations relative to the reaction plane are measured for charged particles in the pseudorapidity range $|η| < 0.8$ and the transverse-momentum range $0.2 < p_{\rm T} < 5$ GeV/$c$. Two approaches have been employed: in the first method, the contribution of the background to the measurement is varied using the event shape engineering (ESE), while the second relies on changing the contribution of the potential CME signal by measuring azimuthal correlations relative to the participant plane, where the background contributions are maximized, and spectator plane, where the CME signal contribution is maximized. Both methods yield results consistent with the absence of a CME signal within the measurement uncertainties. The result obtained from correlations relative to different symmetry planes, a technique applied for the first time at LHC energies, gives the possibility to test independently and confirm the upper limits from previous measurements, while the new limit from the ESE analysis offers improved constraint relative to previous attempts.

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