Professeur des universités en sciences de gestion
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Characteristics and outcomes of ICU patients with sepsis transmitted by cats and dogs: the PETSEPSIS multicentre retrospective observational cohort study
- Type de publi. : Article dans une revue
- Date de publi. : 22/07/2025
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Auteurs :
Juliette QuintinAurélie Le ThuautFabienne PlouvierYoann ZerbibMichel SirodotNicholas SedillotKahaia de LongeauxAnthony Le MeurBertrand SouweineJean-Pierre QuenotJean-Claude LacheradeJulie NoublancheMickael LandaisDidier TheveninSaad NseirThomas LafonThierry VanderlindenRoland SmonigLaurent ArgaudLouis ChauvelotMarlène DuboisR. LarcherFlorian BerteauJean DellamonicaSaber Davide BarbarMathieu SerieToufik KamelFrederic JacobsNicolas de ProstJérôme DevaquetNicholas HemingMarc Pineton de ChambrunPhilippe MichelMichel DjibréAlexis FerreWalter PicardKieran PinceauxFabienne TamionFrancois LegayMaud JonasAnais CurtiaudStephan EhrmannJulien HuntzingerChristophe CraccoFrédérique SchortgenPhilippe LetocartJean Reignier
Fiche détaillée
Characteristics and outcomes of ICU patients with sepsis transmitted by cats and dogs: the PETSEPSIS multicentre retrospective observational cohort study
- Type de publi. : Article dans une revue
- Date de publi. : 22/07/2025
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Auteurs :
Juliette QuintinAurélie Le ThuautFabienne PlouvierYoann ZerbibMichel SirodotNicholas SedillotKahaia de LongeauxAnthony Le MeurBertrand SouweineJean-Pierre QuenotJean-Claude LacheradeJulie NoublancheMickael LandaisDidier TheveninSaad NseirThomas LafonThierry VanderlindenRoland SmonigLaurent ArgaudLouis ChauvelotMarlène DuboisR. LarcherFlorian BerteauJean DellamonicaSaber Davide BarbarMathieu SerieToufik KamelFrederic JacobsNicolas de ProstJérôme DevaquetNicholas HemingMarc Pineton de ChambrunPhilippe MichelMichel DjibréAlexis FerreWalter PicardKieran PinceauxFabienne TamionFrancois LegayMaud JonasAnais CurtiaudStephan EhrmannJulien HuntzingerChristophe CraccoFrédérique SchortgenPhilippe LetocartJean Reignier
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Organismes :
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Centre Hospitalier Agen-Nérac
Médecine Intensive-Réanimation [CHU Amiens]
UFR de Médecine - Université de Picardie Jules Verne
Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois]
Centre Hospitalier Fleyriat [Bourg en Bresse]
Centre Hospitalier Régional Universitaire de Brest
Centre Hospitalier de Cholet
CHU Clermont-Ferrand
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon
Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis
Centre Hospitalier Le Mans (CH Le Mans)
Centre Hospitalier de Lens
Centre Hospitalier Régional Universitaire [CHU Lille]
Centre Hospitalier Universitaire Dupuytren 1 et 2
Centre d'Investigation Clinique de Limoges
Experience ; Technology & Human Interactions ; Care & Society :
Groupement des Hôpitaux de l'Institut Catholique de Lille
Centre Hospitalier de Lorient
Hôpital Edouard Herriot [CHU - HCL]
Hospices Civils de Lyon
Hôpital de la Croix-Rousse [CHU - HCL]
Hospices Civils de Lyon
Centre hospitalier de Montauban
Centre Hospitalier Régional Universitaire [Montpellier]
Centre Hospitalier des Pays de Morlaix
Centre Hospitalier Universitaire de Nice
Unité de Recherche Clinique Côte d’Azur
Centre Hospitalier Universitaire de Nîmes
Centre hospitalier territorial Gaston-Bourret [Dumbea, Nouvelle-Calédonie]
Centre Hospitalier Universitaire d'Orléans
AP-HP - Hôpital Antoine Béclère [Clamart]
AP-HP - Hôpital Henri-Mondor
Hôpital Foch [Suresnes]
AP-HP - Hôpital Raymond Poincaré
Université de Versailles Saint-Quentin-en-Yvelines
AP-HP - Hôpital de la Pitié Salpêtrière
Hôpital NOVO
AP-HP - Hôpital Tenon
Centre Hospitalier de Versailles André Mignot
CHU de Pau
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
CHU Rouen
Hôpital de Saint-Brieuc [Hôpital Yves Le Foll]
Centre hospitalier de Saint-Nazaire
Hôpitaux Universitaires de Strasbourg
Nanomédecine Régénérative
Centre d’Etude des Pathologies Respiratoires [Tours]
Centre Hospitalier Régional Universitaire de Tours
Centre hospitalier Bretagne Atlantique (Morbihan)
Centre Hospitalier d'Angoulême
Centre Hospitalier Intercommunal de Créteil
Centre hospitalier de Rodez
Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance
Hôpital Hôtel-Dieu [CHU Nantes]
- Publié dans Critical Care le 31/10/2020
Résumé : Background Millions of households have cats or dogs as pets, and infections due to bites or scratches are increasing, with the most common pathogens being Pasteurella spp., Bartonella spp., Capnocytophaga spp, and Francisella tularensis. The objective of this study was to describe patients admitted to the intensive care unit (ICU) for infection transmitted by cats or dogs, as well as their outcomes. Methods The retrospective multicentre observational cohort study PETSEPSIS included consecutive adults admitted to 46 ICUs in France between 2009 and 2019 for sepsis due to cat or dog bites and/or caused by any of the four above-listed bacteria. We described their features and outcomes and performed univariate and multivariate analyses to identify factors associated with death. Results We included 174 patients with a median age of 64 [50–74] years; 58.1% were male. The median SAPS II score was 42 [28–58]. Mechanical ventilation was required in 51.2% of patients, for a median duration of 7 [4–13] days. Vasopressor support was used in 53.5%, renal replacement therapy in 19%, and limb amputation in 3.6% of the patients. The median ICU length of stay was 7 [4–16] days. Hospital mortality was 24.1%. The clinical presentation and severity of sepsis were similar across bacteria, although patients with Pasteurella spp. were older and had more comorbidities. Contact with cats were more often reported for Pasteurella spp. and Bartonella spp. infections and contact with dogs for Capnocytophaga spp. infections. Risk factors for hospital mortality present on ICU admission were older age, smoking, preexisting liver disease, high serum creatinine, and anaemia. Neither the type of micro-organism nor the initial antimicrobial treatment was associated with mortality. Conclusions This large multicentre study shows that infections transmitted by cats and dogs are infrequent reasons for ICU admission but are associated with substantial morbidity and mortality. Mortality was associated with older age and comorbidities but not with the type of microorganism or initial antibiotic treatment.
Fichiers liés :
s13054-025-05558-6-2.pdf
Source
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Kinetic mechanisms and species densities in Ar/N 2 , He/N 2 and H 2 /N 2 reduced pressure afterglows
- Type de publi. :
- Date de publi. : 20/07/2025
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Auteurs :
Jean-Philippe SarretteAndré RicardJ P GardouF. Marchal
Fiche détaillée
Kinetic mechanisms and species densities in Ar/N 2 , He/N 2 and H 2 /N 2 reduced pressure afterglows
- Type de publi. :
- Date de publi. : 20/07/2025
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Auteurs :
Jean-Philippe SarretteAndré RicardJ P GardouF. Marchal
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Organismes :
Plasmas Réactifs Hors Equilibre
LAboratoire PLasma et Conversion d'Energie
Plasmas Réactifs Hors Equilibre
Résumé : Emission spectra of nitrogen and of mixtures of nitrogen with argon, helium and hydrogen were studied by Optical Emission Spectroscopy (OES) in the afterglows of flowing microwave discharges. Absolute concentrations of N, N 2 (X, v'=12-13), N 2 (A) and N 2 + were determined in the mixtures at different distances from the discharge from band intensity ratios and from NO titration. In Ar/N 2 and He/N 2 mixtures, absolute N atom densities were compared with Two-photon Absorption Laser-Induced Fluorescence (TALIF) measurements. As all bands originating from the v' = 0-12 levels of the N 2 (B) state were observed, it was possible to obtain rate coefficients for the N-atom 3-body recombination towards every N 2 (B,v') levels in each studied mixture. In H 2 /N 2 mixtures, absolute H-atoms densities were also measured with the TALIF technique and a kinetic model was built, demonstrating how H and NH densities can be derived from the observed NH A-X (0-0) band intensity at 336 nm.
Fichiers liés :
Sarrette et al_ICPIG2025.pdf
Source
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Protecting crops with plant diversity: Agroecological promises, socioeconomic lock-in, and political levers
- Type de publi. : Article dans une revue
- Date de publi. : 18/07/2025
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Auteurs :
Aude VialatteAnaïs TibiAudrey AlignierValérie AngeonLaurent BedoussacDavid A BohanDouadia BougheraraCordeau, S.Pierre CourtoisJean-Philippe DeguineJérôme EnjalbertFrédéric FabreHélène FrévilleBenoît GrimonprezNicolas GrossMourad HannachiMarie LaunayStéphane LemariéGilles MartelMireille NavarreteManuel PlantegenestVirginie RavignéAdrien RuschFrédéric SuffertSophie ThoyerVincent Martinet
Fiche détaillée
Protecting crops with plant diversity: Agroecological promises, socioeconomic lock-in, and political levers
- Type de publi. : Article dans une revue
- Date de publi. : 18/07/2025
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Auteurs :
Aude VialatteAnaïs TibiAudrey AlignierValérie AngeonLaurent BedoussacDavid A BohanDouadia BougheraraCordeau, S.Pierre CourtoisJean-Philippe DeguineJérôme EnjalbertFrédéric FabreHélène FrévilleBenoît GrimonprezNicolas GrossMourad HannachiMarie LaunayStéphane LemariéGilles MartelMireille NavarreteManuel PlantegenestVirginie RavignéAdrien RuschFrédéric SuffertSophie ThoyerVincent Martinet
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Organismes :
Dynamiques et écologie des paysages agriforestiers
Direction de l'Expertise scientifique collective, de la Prospective et des Etudes
Biodiversité agroécologie et aménagement du paysage
Ecodéveloppement
AGroécologie, Innovations, teRritoires
Agroécologie [Dijon]
Centre d'Economie de l'Environnement - Montpellier
Agroécologie [Dijon]
Centre d'Economie de l'Environnement - Montpellier
Plant Health Institute of Montpellier
Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale)
Santé et agroécologie du vignoble
Amélioration génétique et adaptation des plantes méditerranéennes et tropicales
Centre d’études et de coopération juridique interdisciplinaire – Université de Poitiers [UR 20418]
Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR
Sciences pour l'Action et le Développement : Activités, Produits, Territoires
Agroclim
Laboratoire d'Economie Appliquée de Grenoble
Biodiversité agroécologie et aménagement du paysage
Ecodéveloppement
Institut de Génétique, Environnement et Protection des Plantes
Peuplements végétaux et bioagresseurs en milieu tropical
Santé et agroécologie du vignoble
BIOlogie et GEstion des Risques en agriculture
Centre d'Economie de l'Environnement - Montpellier
Paris-Saclay Applied Economics
- Publié dans One Earth le 13/11/2020
Résumé : Plant diversification at field, farm, and landscape scales is a key strategy for protecting crops from pests. But its level of adoption remains confidential, while the overall negative impacts of pesticides are now well established. To understand the obstacles to this adoption, we conducted an extensive review of literature in life and socio-economic sciences. We found that all diversification practices are largely effective in pest control, achieving satisfactory yields and many ecological cobenefits, although context dependent. Plant diversification does not appear solely as an alternative to pesticide-based pest control but as a transformative approach to achieve sustainable agrifood systems. However, its adoption is currently strongly hindered by socioeconomic barriers, including low short-term profitability, rigid agricultural sectors, and limited support from public policies. The most beneficial practices, agroforestry and diversified landscapes, face the greatest obstacles. In contrast, cultivar mixtures, while easier to implement, offer limited cobenefits. Collaboration between scientists, policymakers, and local stakeholders seems essential to scale up plant diversification.
Fichiers liés :
Vialatte et al. 2025 One Earth.pdf
Source
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Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study
- Type de publi. : Article dans une revue
- Date de publi. : 16/07/2025
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Auteurs :
Julien VaidieJulien DemiselleAnthony GabrielAntoine GuillonEdwige PéjuFrédéric PènePiotr SzychowiakBoris DelangePauline GuillotJean-Claude LacheradePierre AsfarAnn ZaluckyPhilippe VignonBruno EvrardBruno François
Fiche détaillée
Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study
- Type de publi. : Article dans une revue
- Date de publi. : 16/07/2025
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Auteurs :
Julien VaidieJulien DemiselleAnthony GabrielAntoine GuillonEdwige PéjuFrédéric PènePiotr SzychowiakBoris DelangePauline GuillotJean-Claude LacheradePierre AsfarAnn ZaluckyPhilippe VignonBruno EvrardBruno François
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Organismes :
Centre Hospitalier Universitaire Dupuytren 1 et 2
Nanomédecine Régénérative
Centre de Recherche en Biomédecine de Strasbourg
Fédération de Médecine Translationnelle de Strasbourg
Centre Hospitalier Universitaire [Strasbourg]
Centre Hospitalier Universitaire Dupuytren 1 et 2
Centre Hospitalier Régional Universitaire de Tours
Centre d’Etude des Pathologies Respiratoires [Tours]
Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
AP-HP - Hôpital Cochin
Centre Hospitalier Régional d'Orléans
Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou]
Laboratoire Traitement du Signal et de l'Image
Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou]
Centre Hospitalier Départemental Vendée
Centre Hospitalier Universitaire d'Angers
University of Calgary
Centre Hospitalier Universitaire Dupuytren 1 et 2
Centre d'Investigation Clinique de Limoges
Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
Centre Hospitalier Universitaire Dupuytren 1 et 2
Centre d'Investigation Clinique de Limoges
Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
Centre Hospitalier Universitaire Dupuytren 1 et 2
Centre d'Investigation Clinique de Limoges
Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
- Publié dans Intensive Care Medicine le 27/10/2020
Résumé : Purpose: Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of immunosuppressive drugs > 24h) on day-90 mortality and ICU-acquired infections. Methods: This multicenter observational retrospective study conducted in solid organ transplant patients admitted to nine ICUs used a Bayesian approach with priors based on a belief elicitation process conducted among a panel of experts. Results: Among 591 enrolled patients, suspension strategy was used in 34% of them, during a median period of 5 days [IQR: 3-10]. This approach was more common in patients admitted for sepsis (38%) or COVID-19 (49%) than for non-septic causes (24%) (p < 0.001). Overall, day-90 mortality reached 30%, and Bayesian analysis revealed substantial uncertainty with an OR at 1.13 (95% Credible Interval (CrI): 0.74-1.70), and a 15% probability of a beneficial effect. In the subgroup of patients with sepsis, OR was at 0.90 (95% CrI: 0.55-1.55), with a 50% probability of a beneficial effect. ICU-acquired infections occurred in 26% of patients. The suspension strategy indicated a potential benefit, both in the entire cohort, with a 73% probability of a beneficial effect [OR: 0.74 (95% CrI: 0.49-1.15)], and in the subgroup of sepsis patients with a 78% probability of beneficial effect [OR 0.70 (95% CrI, 0.42-1.16)]. Conclusion: Temporary suspension of immunosuppressive drugs may reduce the risk of ICU-acquired infections, with a true uncertainty on day-90 mortality. Prospective studies are warranted to confirm these results.
Source
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Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study
- Type de publi. : Article dans une revue
- Date de publi. : 16/07/2025
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Auteurs :
Pierre BayÉtienne AudureauSlim FouratiNicolas de ProstSébastien PréauRaphaël FavoryAurélie GuigonNicholas HemingElyanne GaultTài PhamAmal ChaghouriMatthieu TurpinLaurence Morand-JoubertSébastien JochmansAurélia PitschSylvie MeirelesDamien ContouAmandine HenryAdrien JosephMarie-Laure ChaixFabrice UhelDamien RouxDelphyne DescampsMalo EmeryClaudio Garcia-SanchezDavid LevySonia BurrelJulien MayauxAntoine KimmounCédric HartardFrédéric PèneFlore RozenbergStéphane GaudrySégolène BrichlerAntoine GuillonLynda HandalaFabienne TamionAlice MoisanThomas DaixSébastien HantzFlora DelamaireV. ThibaultBertrand SouweineCecile HenquellLucile PicardFrançoise BotterelChristophe RodriguezArmand Mekontso DessapJean-Michel PawlotskyKeyvan RazaziRaphaël BellaïcheElie AzoulayJean-François TimsitGuillaume VoiriotNina de MontmollinStéphane MarotDjeneba Bocar FofanaCharles-Edouard LuytDjillali AnnaneFerhat MezianiLouis-Marie JandeauxSamira Fafi-KremerCédric DarreauJean ThominAnaïs DartevelSylvie LarratEvelyne SchvoererCédric HartardBéatrice La CombeSéverine HaouiseeSami HraeichPierre-Edouard FournierPhilippe ColsonEmmanuel CanetBerthe Marie ImbertGuillaume ThierySylvie PilletRémy CoudroyNicolas LevequeClément SaccheriValérie GiordanengoKada KloucheEdouard TuaillonCécile AubronAdissa TranJean-Marc TadiéJean-Christophe PlantierSophie Vallet
Fiche détaillée
Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study
- Type de publi. : Article dans une revue
- Date de publi. : 16/07/2025
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Auteurs :
Pierre BayÉtienne AudureauSlim FouratiNicolas de ProstSébastien PréauRaphaël FavoryAurélie GuigonNicholas HemingElyanne GaultTài PhamAmal ChaghouriMatthieu TurpinLaurence Morand-JoubertSébastien JochmansAurélia PitschSylvie MeirelesDamien ContouAmandine HenryAdrien JosephMarie-Laure ChaixFabrice UhelDamien RouxDelphyne DescampsMalo EmeryClaudio Garcia-SanchezDavid LevySonia BurrelJulien MayauxAntoine KimmounCédric HartardFrédéric PèneFlore RozenbergStéphane GaudrySégolène BrichlerAntoine GuillonLynda HandalaFabienne TamionAlice MoisanThomas DaixSébastien HantzFlora DelamaireV. ThibaultBertrand SouweineCecile HenquellLucile PicardFrançoise BotterelChristophe RodriguezArmand Mekontso DessapJean-Michel PawlotskyKeyvan RazaziRaphaël BellaïcheElie AzoulayJean-François TimsitGuillaume VoiriotNina de MontmollinStéphane MarotDjeneba Bocar FofanaCharles-Edouard LuytDjillali AnnaneFerhat MezianiLouis-Marie JandeauxSamira Fafi-KremerCédric DarreauJean ThominAnaïs DartevelSylvie LarratEvelyne SchvoererCédric HartardBéatrice La CombeSéverine HaouiseeSami HraeichPierre-Edouard FournierPhilippe ColsonEmmanuel CanetBerthe Marie ImbertGuillaume ThierySylvie PilletRémy CoudroyNicolas LevequeClément SaccheriValérie GiordanengoKada KloucheEdouard TuaillonCécile AubronAdissa TranJean-Marc TadiéJean-Christophe PlantierSophie Vallet
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Organismes :
Centre de recherche en épidémiologie et santé des populations
AP-HP - Hôpital Bicêtre [Le Kremlin-Bicêtre]
- Publié dans Intensive Care Medicine le 27/10/2020
Source
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Expert Perspectives on Incorporating GLP-1 RA in Diabetes and Chronic Kidney Disease – Challenges and Opportunities
- Type de publi. : Article dans une revue
- Date de publi. : 15/07/2025
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Auteurs :
Jean-Michel HalimiLaurent FauchierAlexandre KarrasChloé AmouyalDominique EladariPatrick RossignolGabriel ChoukrounPhilippe ZaouiNicolas GirerdSamy Hadjadj
Fiche détaillée
Expert Perspectives on Incorporating GLP-1 RA in Diabetes and Chronic Kidney Disease – Challenges and Opportunities
- Type de publi. : Article dans une revue
- Date de publi. : 15/07/2025
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Auteurs :
Jean-Michel HalimiLaurent FauchierAlexandre KarrasChloé AmouyalDominique EladariPatrick RossignolGabriel ChoukrounPhilippe ZaouiNicolas GirerdSamy Hadjadj
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Organismes :
Service de néphrologie et immunologie clinique [CHRU Tours]
Membrane Signalling and Inflammation in reperfusion Injuries
Investigation Network Initiative - Cardiovascular and Rénal Clinical Trialist
Centre Hospitalier Régional Universitaire de Tours
AP-HP - Hôpital Européen Georges Pompidou
Université Paris Cité
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
Nutrition et obésités: approches systémiques (UMR-S 1269)
Centre Hospitalier Universitaire d'Amiens-Picardie
Université de Picardie Jules Verne
Paris-Centre de Recherche Cardiovasculaire
Plateforme F-CRIN
Défaillance Cardiovasculaire Aiguë et Chronique
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
French-Clinical Research Infrastructure Network - F-CRIN [Paris]
Centre Hospitalier Princesse Grace
Service de Néphrologie-Dialyse-Transplantation [CHU Amiens-Picardie]
HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666
Université Grenoble Alpes - UFR Médecine
Défaillance Cardiovasculaire Aiguë et Chronique
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
French-Clinical Research Infrastructure Network - F-CRIN [Paris]
ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
- Publié dans European Journal of Preventive Cardiology le 25/10/2020
Résumé : Chronic kidney disease (CKD) is a complex and progressive condition ultimately leading to premature death. Diabetes is the leading cause of end-stage kidney disease worldwide. Up till 2024, international clinical guidelines have established three therapeutic pillars to delay CKD progression in people with type 2 diabetes (T2D): renin-angiotensin system inhibitors, sodium-glucose cotransporter 2 inhibitors, and the non-steroidal mineralocorticoid receptor antagonist finerenone. With the recent results from the Evaluate Renal Function with Semaglutide Once Weekly (FLOW) study, the glucagon-like peptide-l receptor agonist (GLP-1 RA) class is now considered a new therapeutic pillar in reducing CKD complications in this patient population. In this expert opinion, we identify patient populations at risk of developing new onset or worsening pre-existing CKD to explore optimal therapeutic strategies, introducing GLP-1 RAs. We highlight the important challenges that remain in optimizing, sequencing, and combining these four therapeutic pillars. Even though the conventional approach of combining the pillars has been based on the historical emergence of evidence, we discuss the factors that would influence physicians’ decision for preferring one pillar over another, and for selecting a certain combination, whether performed simultaneously or sequentially. These factors include the grade of CKD and the level of albuminuria; diabetic control (glycemia); comorbidities: atherosclerotic cardiovascular disease, heart failure, obesity; concomitant medications; biological variables: potassium serum levels. The efficacy and safety profiles of each pillar, as demonstrated in landmark trials that have clearly shown the nephroprotective effects, along with real-world data, should also be carefully considered when selecting the most appropriate therapeutic option.
Fichiers liés :
zwaf426.pdf
Source
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Detection Prospects for AGNs with the Cherenkov Telescope Array
- Type de publi. : Communication dans un congrès
- Date de publi. : 15/07/2025
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Auteurs :
Luana Passos ReisElisabete de Gouveia Dal PinoTarek HassanSantiago PitaJonathan BiteauJean-Philippe LenainAtreya AcharyyaAlberto DominguezLucas GréauxLuiz Augusto Stuani PereiraEdivaldo Moura SantosPaolo Goldoni
Fiche détaillée
Detection Prospects for AGNs with the Cherenkov Telescope Array
- Type de publi. : Communication dans un congrès
- Date de publi. : 15/07/2025
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Auteurs :
Luana Passos ReisElisabete de Gouveia Dal PinoTarek HassanSantiago PitaJonathan BiteauJean-Philippe LenainAtreya AcharyyaAlberto DominguezLucas GréauxLuiz Augusto Stuani PereiraEdivaldo Moura SantosPaolo Goldoni
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Organismes :
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Laboratoire de Physique Nucléaire et de Hautes Énergies
Résumé : The Cherenkov Telescope Array Observatory (CTAO) will enable detailed studies of Active Galactic Nuclei (AGN) in the very-high-energy (VHE) regime, as the next-generation ground-based gamma-ray observatory, designed to enhance sensitivity and energy coverage (20 GeV - 300 TeV) over current Imaging Atmospheric Cherenkov Telescopes (IACTs). In the context of the CTAO Science Collaboration, within the AGN Population working group, we developed a variability-based strategy to improve predictions of AGNs detectable by CTAO, using Fermi-LAT data and normalized excess variance (NXS) as a tracer of flux variability. By extrapolating from 30-day to 3-day timescales, we expanded the sample of sources with short-timescale variability estimates from 87 to 407. This approach allows us to identify flaring and distant AGNs that are promising CTAO targets. The results are being used to support the CTAO extragalactic science program and will be included in an upcoming Consortium publication for the AGN Population collaboration.
Source
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The Effects of Daridorexant on Patients With Comorbid Insomnia Disorder and Untreated Mild Obstructive Sleep Apnoea: A Post Hoc Subgroup Analysis of a Phase 3, Randomised Clinical Trial
- Type de publi. : Article dans une revue
- Date de publi. : 14/07/2025
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Auteurs :
Christopher LettieriOrestis BriasoulisDamien LégerPierre‐philippe LuyetJean‐louis PépinStuart QuanJanna RaphelsonPaul SaskinAtul Malhotra
Fiche détaillée
The Effects of Daridorexant on Patients With Comorbid Insomnia Disorder and Untreated Mild Obstructive Sleep Apnoea: A Post Hoc Subgroup Analysis of a Phase 3, Randomised Clinical Trial
- Type de publi. : Article dans une revue
- Date de publi. : 14/07/2025
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Auteurs :
Christopher LettieriOrestis BriasoulisDamien LégerPierre‐philippe LuyetJean‐louis PépinStuart QuanJanna RaphelsonPaul SaskinAtul Malhotra
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Organismes :
Hypoxie et PhysioPathologie
- Publié dans Journal of Sleep Research le 26/10/2020
Résumé : ABSTRACT Daridorexant, a dual orexin receptor antagonist, is approved for the treatment of insomnia disorder in adults. Approximately 30%–35% of patients with insomnia disorder also have obstructive sleep apnoea (OSA) of any severity. It is unclear whether sleep medications provide safe and effective treatment for insomnia in these patients. This post hoc analysis evaluated the efficacy and safety of daridorexant 25 and 50 mg on objective and self‐reported insomnia variables and self‐reported daytime functioning in patients with untreated mild OSA and comorbid insomnia disorder (COMISA). This analysis included participants with insomnia disorder enrolled in the Phase 3 study assessing either daridorexant 25 or 50 mg with an apnoea/hypopnoea index 5–< 15 events/h (‘mild OSA’). Wake after sleep onset (WASO), latency to persistent sleep (LPS), self‐reported total sleep time (sTST) and the Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ) were assessed at Months 1 and 3. Safety endpoints were treatment‐emergent adverse events, daytime somnolence and next‐morning residual effects. In participants with mild OSA, daridorexant improved WASO, LPS, sTST and IDSIQ total score over time. The average treatment effect size for all efficacy parameters was numerically greater with daridorexant 50 mg than with daridorexant 25 mg; daridorexant 25 mg was not always greater than placebo. No safety concerns were reported for daridorexant 50 or 25 mg. In participants with comorbid insomnia and untreated mild OSA, daridorexant 50 mg versus placebo improved all sleep parameters over time and was well tolerated. Daridorexant warrants further investigation in COMISA. Trial Registration: ClinicalTrials.gov identifier: NCT03545191
Source
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Design and characterization of the Flat-Field Calibration of the NectarCAM Camera
- Type de publi. : Communication dans un congrès
- Date de publi. : 14/07/2025
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Auteurs :
Anastasiia MikhnoFederica BradascioJonathan BiteauFrançois BrunPatrick BrunHossam BoutalhaJustine DevinA. Jardin-BlicqPierre JeanMichael JosselinJean-Philippe LenainQuentin LuceVincent MarandonKevin PressardGeorges Vasileiadis
Fiche détaillée
Design and characterization of the Flat-Field Calibration of the NectarCAM Camera
- Type de publi. : Communication dans un congrès
- Date de publi. : 14/07/2025
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Auteurs :
Anastasiia MikhnoFederica BradascioJonathan BiteauFrançois BrunPatrick BrunHossam BoutalhaJustine DevinA. Jardin-BlicqPierre JeanMichael JosselinJean-Philippe LenainQuentin LuceVincent MarandonKevin PressardGeorges Vasileiadis
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Organismes :
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Laboratoire de Physique Nucléaire et de Hautes Énergies
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Institut universitaire de France
Laboratoire Univers et Particules de Montpellier
Institut de Recherches sur les lois Fondamentales de l'Univers
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Laboratoire Univers et Particules de Montpellier
Laboratoire de Physique des Deux Infinis Bordeaux
Institut de recherche en astrophysique et planétologie
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Laboratoire de Physique Nucléaire et de Hautes Énergies
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Institut de Recherches sur les lois Fondamentales de l'Univers
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Laboratoire Univers et Particules de Montpellier
Résumé : The NectarCAM flat-field flasher is a calibration device designed for the camera that will equip the Medium-Sized Telescopes (MSTs) of the northern site of the Cherenkov Telescope Array Observatory (CTAO). Positioned in the centre of the MST dish, 16 meters in front of the camera, the flasher emits short (FWHM $\approx$ 5 ns), uniform (2$-$4%) light pulses to illuminate the entire focal plane. Accurate calibration is crucial for the optimal operation of the NectarCAM, ensuring precise gain computation and mitigating differences in light-collection efficiency of the pixels of the camera. Using the flat-field flasher, two informations are obtained : the pixel gain and the relative efficiency between pixels. In addition, the flasher is used to probe the dynamic range over which the camera operates effectively. In this study, we report on the performance characterisation of the flat-field flasher using a dedicated test bench. We report on the results of tests conducted on several flasher units, evaluating their reliability. Furthermore, we describe how the flat-field coefficients are applied within the camera to ensure uniformity of response of few percent level across all 1855 pixels. As the deployment of the first MST at the CTAO northern site is scheduled for 2027, this work represents a significant contribution to the collaboration`s efforts to finalize camera calibration systems.
Source
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Cerizine
- Type de publi. :
- Date de publi. : 13/07/2025
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Auteurs :
Madeleine AktypiClaire AudiffretViolette BastitPierre BayardÉmilie CanniauxAdrien ChapelAdrien ChassainYves CittonCharles CoustilleJérôme DavidAxelle DelagorceMariette DelinièreArthur DumasMarion Dupouy MasonPhilippe FauvernierSalomé FauvinetEléonore GaudryIsabelle GermainRaphaëlle GuidéeMaryline HeckEdith HeurgonJacob Jean-JacquesArilys JiaClaire LarsonneurAlice LeclercqMathieu MessagerMurzilli NancyMagali NachtergaelPauline NoblecourtAlexis NysMarion OliveiraLéa OriolMathieu PicquenotSophie PrinssenCyril PuertolasSophie RabauLaureline RichardOlivia RosenthalMathilde RoussignéBenjamin RouxAlexandra SaemmerAnne-Frédérique SchläpferFrançois SinagraGabriele SteraMyriam SuchetValérie TachonLaurane Travagli-ChanalYann TrividicDimitri VotanoMartin VotanoSheun VuMarie WillaimeMarie-Jeanne Zenetti
Fiche détaillée
Cerizine
- Type de publi. :
- Date de publi. : 13/07/2025
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Auteurs :
Madeleine AktypiClaire AudiffretViolette BastitPierre BayardÉmilie CanniauxAdrien ChapelAdrien ChassainYves CittonCharles CoustilleJérôme DavidAxelle DelagorceMariette DelinièreArthur DumasMarion Dupouy MasonPhilippe FauvernierSalomé FauvinetEléonore GaudryIsabelle GermainRaphaëlle GuidéeMaryline HeckEdith HeurgonJacob Jean-JacquesArilys JiaClaire LarsonneurAlice LeclercqMathieu MessagerMurzilli NancyMagali NachtergaelPauline NoblecourtAlexis NysMarion OliveiraLéa OriolMathieu PicquenotSophie PrinssenCyril PuertolasSophie RabauLaureline RichardOlivia RosenthalMathilde RoussignéBenjamin RouxAlexandra SaemmerAnne-Frédérique SchläpferFrançois SinagraGabriele SteraMyriam SuchetValérie TachonLaurane Travagli-ChanalYann TrividicDimitri VotanoMartin VotanoSheun VuMarie WillaimeMarie-Jeanne Zenetti
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Organismes :
Fabrique du littéraire
Fabrique du littéraire
Fabrique du littéraire
Fabrique du littéraire
Université d'État d'Haïti
Université du Québec à Chicoutimi
Transferts critiques anglophones
Littératures antiques et modernes
Centre de recherches sur les arts et le langage
Fabrique du littéraire
PLURIELLES Langues, littératures, civilisation (UR 24142)
THALIM - Théorie et histoire des arts et des littératures de la modernité - UMR 7172
Centre d'études sur les médias, les technologies et l'internationalisation
École universitaire de recherche ArTeC
Fabrique du littéraire
Ecole doctorale Pratiques et théories du sens
Aix-Marseille Université - Faculté des Arts, Lettres, Langues et Sciences Humaines
THALIM - Théorie et histoire des arts et des littératures de la modernité - UMR 7172
Extreme Situated Interaction - LISN
Passages XX-XXI
Fichiers liés :
cerizine_complet_avec_inserts.pdf
Source
Directeur de l’Ecole Doctorale Sciences Humaines et Sociales