Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/07/2025
• Auteurs : Jean-Charles LeclercT LeA BaudElea GonthierS DittamiF ThomasG TanguyA NicolleMarine MoalM GonzalezAurore RaouxRomain Crec'HriouCaroline BroudinCéline HoubinLucille CaradecL BlondelE LegeayD PottinS LoiselL. SevinJérôme CoudretAline MignéDominique DavoultThomas BurelG SchiresJean-Philippe PezyP PotinÉric Thiébaut
• Organismes : Morphodynamique Continentale et Côtière Station biologique de Roscoff = Roscoff Marine Station Fédération de recherche de Roscoff Station biologique de Roscoff = Roscoff Marine Station OSU Stations marines Fédération de recherche de Roscoff Adaptation et diversité en milieu marin Adaptation et diversité en milieu marin Fédération de recherche de Roscoff Station biologique de Roscoff = Roscoff Marine Station Adaptation et diversité en milieu marin

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Fawzi KerkouriRomain EschalierSamir FarehChristelle MarquiéMina Ait SaidWalid AmaraFrédéric AnselmeMarc BadozNathalie BeharPierre BordacharRim El BouazzaouiLaure Champ RigotMichel ChauvinPhilippe ChevalierAntoine da CostaPascal DefayeJean Claude DeharoLaurent FauchierEstelle GandjbakhchEdouard GitenayJean-Baptiste GourraudCharles GuenanciaMaxime de GuillebonBenoît Guy-MoyatAlexis HermidaJérôme HourdainPeggy JaconPierre KhattarMikael LaredoLaurence Jesel-MorelNicolas LelloucheChristophe LeclercqVincent MansouratiPhilippe MauryPierre MondolyJean-Luc PasquiéMichaël PeyrolBertrand PierreSylvain PlouxCharlotte PotelleNicolas SadoulJean Marc SellalEmilie VarletRodrigue GarciaVincent ProbstSerge BovedaEloi Marijon
• Organismes : Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques Service de cardiologie [CHU HEGP] Paris-Centre de Recherche Cardiovasculaire CHU Clermont-Ferrand Hôpital de la Croix-Rousse [CHU - HCL] Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Privé Jacques Cartier [Massy] Groupe Hospitalier Intercommunal Le Raincy-Montfermeil Service de Cardiologie [CHU Rouen] Service de cardiologie [CHRU de Besançon] Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Département de cardiologie Centre Hospitalier Libourne Service de cardiologie et de pathologie vasculaire [CHU Caen] Clinique de l'Orangerie [Strasbourg] Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie Service de Cardiologie [CHU Saint-Etienne] Département de cardiologie [CHU de Grenoble] Département de Cardiologie [Hôpital de la Timone - APHM] Centre Hospitalier Régional Universitaire de Tours Institut de cardiologie [CHU Pitié-Salpêtrière] Departement de Cardiologie [Hôpital Saint-Joseph - Marseille] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de Cardiologie [CHU de Dijon] Centre hospitalier de Pau Service de cardiologie [CHU Limoges] Neurologie [CHU Amiens] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Département de Cardiologie [Hôpital de la Timone - APHM] Département de cardiologie [CHU de Grenoble] Groupe Hospitalier Bretagne Sud Institut de cardiologie [CHU Pitié-Salpêtrière] Centre Hospitalier Universitaire [Strasbourg] Service de Cardiologie [CHU Henri Mondor] Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques Service Cardiologie [CHU Toulouse] Service Cardiologie [CHU Toulouse] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Service de cardiologie [Hôpital Nord - APHM] Centre Hospitalier Régional Universitaire de Tours Département de cardiologie Centre Hospitalier Régional Universitaire [CHU Lille] Service de Cardiologie [CHRU Nancy] Service de Cardiologie [CHRU Nancy] Service de cardiologie [CHU HEGP] Service de cardiologie [CHU de Poitiers] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Clinique Pasteur [Toulouse] Service de cardiologie [CHU HEGP]
• Publié dans Journal of the American College of Cardiology le 26/10/2020

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Résumé : Background: Defibrillation testing (DT) remains recommended during subcutaneous implantable cardioverter defibrillator (S-ICD) implantation due to limited supporting evidence. Objectives: The objective of this study was to evaluate the long-term impact of DT during S-ICD implantation. Methods: The HONEST (coHOrte fraNcaise des dEfibrillateurs Sous cuTanés) study is a nationwide, ongoing observational study, including all S-ICD recipients in France (2012-2019). Five-year endpoints were centrally adjudicated, and propensity score-weighted analyses compared outcomes by DT status. Results: Among 4,924 patients, DT was performed in 4,066 (82.6%), decreasing from 85.4% (2012-2014) to 66.9% in 2019 (P < 0.001). Nontested patients were older (51.2 vs 49.6 years; P = 0.007), had lower left ventricular ejection fraction (37.6% vs 43.3%; P < 0.001), and were more frequently implanted for primary prevention (68.0% vs 62.4%; P = 0.002) and structural heart disease (84.9% vs 76.8%; P < 0.001). DT-related complications occurred in 0.1%, including 2 deaths. Failure rate was 1.0%, with 87.8% undergoing corrective reinterventions. Independent predictors of DT failure were elevated shock impedance (≥89 Ω; OR: 4.60; 95% CI: 2.32-9.66; P < 0.001) and obesity (body mass index ≥30 kg/m2; OR: 2.17; 95% CI: 1.01-4.55; P = 0.007). After adjustment, DT omission was not associated with increased risks of overall mortality (HR: 1.17; 95% CI: 0.86-1.61; P = 0.313), cardiovascular mortality (HR: 1.04; 95% CI: 0.70-1.56; P = 0.846), sudden cardiac death (HR: 0.27; 95% CI: 0.04-1.72; P = 0.167), and appropriate (HR: 1.01; 95% CI: 0.78-1.30; P = 0.945) or inappropriate shocks (HR: 0.98; 95% CI: 0.78-1.23; P = 0.865). Combined rates of ineffective shocks or undetected ventricular arrhythmias were similar (0.05 vs 0.06 per 100 person-years). Conclusions: Our findings suggest that DT can be safely omitted in the majority of S-ICD recipients, whereas selective DT may be considered in higher-risk subgroups. (S-ICD French Cohort Study (HONEST); NCT05302115).

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Fichiers liés : 2025 Kerkouri et al., Defibrillation Testing.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Corentin ChaumontMikael LaredoOlivier ThomasPhilippe MauryGrégoire MassoulliéPascal DefayeSerge BovedaEloi MarijonWilliam EscandeAntoine RouxFranck RaczkaYves GuyomarPierre JaïsPierre OllitraultMathieu GranierSamir FarehHugo MarchandBertrand PierreSelim AbbeyAntoine NoelAntoine da CostaFabrice ExtramianaOlivier CesariLaure Champ-RigotZiad KhoueiryThibault VilleminSarah TraulléFrédéric TreguerHugues BaderJean-Claude DeharoBruno DegandBenoît Guy-MoyatDidier KlugEstelle GandjbakhchAlexandre ZhaoMaxime BeneytoRomain EschalierSandrine VenierStéphane CombesAntoine LepillierMarc MielczarekNicolas ClementyAymeric MenetFrédéric SacherChristian de ChillouFrédéric Anselme
• Organismes : CHU Clermont-Ferrand
• Publié dans Heart Rhythm O2 le 24/04/2022

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Résumé : Most data on atrial fibrillation (AF) ablation using the first available pentaspline pulsed field ablation (PFA) catheter (Farapulse, Boston Scientific Inc) come from retrospective center-level registries collected in highly experienced centers.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Anna Maria AuxiliaEmilie OliéJonathan DuboisEnrico CapuzziValérie AubinBruno AouizerateFrank BellivierRaoul BelzeauxCaroline DubertretDominique JanuelEmmanuel HaffenAntoine LefrereAgnès PelletierMircea PolosanRomain ReyPaul RouxLudovic SamalinRaymund SchwanMichel WalterAntoine YrondiPierre-Michel LlorcaMarion LeboyerB EtainPhilippe Courtet
• Organismes : Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondation FondaMental [Créteil] Institut de Génomique Fonctionnelle Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondazione IRCCS San Gerardo dei Tintori Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondation FondaMental [Créteil] AP-HP - Hôpital Louis Mourier Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre de Recherche Clinique [Neuilly-sur-Marne] Centre d'Investigation Clinique de Besançon Fondation FondaMental [Créteil] Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale AP-HP - Hôpital Henri-Mondor Fondation FondaMental [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Fondation FondaMental [Créteil] Centre Hospitalier le Vinatier [Bron] Équipe Troubles psychiatriques, Recherche en Neurosciences et Recherche Clinique - Psychiatric Disorders, Neuroscience Research and Clinical Research Team Fondation FondaMental [Créteil] Centre de recherche en épidémiologie et santé des populations Centre Hospitalier de Versailles André Mignot Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Hopital de Bohars - CHRU Brest Fondation FondaMental [Créteil] Centre Hospitalier Universitaire de Toulouse Fondation FondaMental [Créteil] Toulouse NeuroImaging Center Fondation FondaMental [Créteil] CHU Clermont-Ferrand Institut Pascal Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Institut Mondor de Recherche Biomédicale Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle
• Publié dans European Psychiatry le 23/10/2020

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Résumé : Introduction: Suicidal behaviors (SB) in bipolar disorder (BD) are major adverse outcomes that may influence disease progression. While staging models exist for psychiatric disorders, none include suicide. This study aims to stratify suicidal risk in BD, propose a staging model for SB, and assess its clinical utility. Methods: Participants from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE-BD) cohort were categorised into five stages (St) based on SB: St0 (no suicidal ideation [SI]), St1 (SI but no suicide attempt [SA]), St2a (non-severe/violent SA), St2b (severe /violent SA), and St3 (multiple SAs). Stages were analysed based on demographic, clinical, cognitive, and biological characteristics using logistic regression. Results: Key differences emerged between stages. St1 showed longer untreated illness and higher lability and lower functioning than St0. St2a was linked to anxiety, substance use disorders, and longer disorder duration, while male gender and lithium bitherapy were protective. St2b exhibited shorter untreated illness and higher childhood trauma (CTQ) scores, with male gender and alcohol use as risk factors. St3 was associated with BD-II, alcohol use, longer disorder duration, and more depressive episodes, but less anxiety. No biochemical or cognitive differences were found across stages. The model was significantly associated with SA occurrence (LRT = 28.74, p < 0.0001). Conclusion: This staging model for suicidality in BD provides a multifaceted approach to risk stratification and predictive insights, although further refinement is needed.

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Fichiers liés : Auxilia et al 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Maxence JamesJacques TrouverieBenoit BernayAnne MarmagneFabien ChardonMarin-Pierre GéminPhilippe EtienneCéline Masclaux‐daubresse
• Organismes : Université de Caen Normandie Ecophysiologie Végétale, Agronomie et Nutritions NCS Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans The Plant Journal le 26/10/2020

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Résumé :

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Fichiers liés : 2025 - James - V‐ATPases and amino acid catabolism are strongly disturbed in the roots of autophagy.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Matthieu LegrandEdouard JullienAntoine KimmounGuillaume GeriHafid Ait-OufellaStanislas AbrardSamuel GaugainFanny BounesPhilippe GuerciJulien PottecherMatthieu JammeYves Poncelin de RaucourtDamien BarraudJean-Michel ConstantinWilliam JuguetSigismond LasockiRomain SonnevilleJuliette AudibertGaëtan PlantefèveOlivier EllrodtAnne-Laure FedouMarc LeoneLaurent LefebvreAdrien AuvetDavid ChenEric VicautFrançois Dépret
• Organismes : University of California French-Clinical Research Infrastructure Network - F-CRIN [Paris] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] AP-HP - Hôpital Ambroise Paré Université de Versailles Saint-Quentin-en-Yvelines Service de Réanimation Médicale [CHRU Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] AP-HP - Hôpital Saint-Antoine Hôpital Edouard Herriot [CHU - HCL] Marqueurs cardiovasculaires en situation de stress Département d’Anesthésie-Réanimation-SMUR [Hôpital Lariboisière] Centre Hospitalier Universitaire de Toulouse Service d'Anesthésie et Réanimation [CHRU Nancy] Défaillance Cardiovasculaire Aiguë et Chronique French-Clinical Research Infrastructure Network - F-CRIN [Paris] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] Hôpitaux Universitaires de Strasbourg Ramsay Générale de Santé - Hôpital Privé La Louvière Centre Hospitalier de Bourg en Bresse Centre hospitalier régional de Metz-Thionville Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital Avicenne Université Sorbonne Paris Nord Centre Hospitalier Universitaire d'Angers AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution Hôpital Louis Pasteur [Chartres] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre Hospitalier de Melun Centre Hospitalier Universitaire Dupuytren 1 et 2 Hôpital Nord [CHU - APHM] Centre Hospitalier d'Aix en Provence Centre Hospitalier Dax - Côte d'Argent University of California AP-HP - Hôpital Saint-Louis [Paris] Marqueurs cardiovasculaires en situation de stress French-Clinical Research Infrastructure Network - F-CRIN [Paris] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] Marqueurs cardiovasculaires en situation de stress Investigation Network Initiative - Cardiovascular and Rénal Clinical Trialist Assistance publique - Hôpitaux de Paris French-Clinical Research Infrastructure Network - F-CRIN [Paris] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
• Publié dans American Journal of Respiratory and Critical Care Medicine le 26/10/2020

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Résumé : Rationale: Preclinical and preliminary clinical data suggest that iloprost may improve tissue perfusion in septic shock. However, its effect on organ failure remains unclear. Objectives: To investigate whether iloprost provides organ protection in septic shock with hypoperfusion. Methods: In this multicenter, double-blind, randomized controlled trial, adults with septic shock and persistent hypoperfusion (i.e., increased capillary refill time and/or skin mottling) were randomized to receive a 48-hour intravenous infusion of iloprost or placebo. The primary outcome was the change in the Sequential Organ Failure Assessment (SOFA) score from randomization to Day 7. Secondary outcomes included mortality at Day 28, organ support-free days by Day 28, and mean daily SOFA score. Measurements and Main Results: A total of 240 patients were randomized, and 236 were included in the analysis. Median (IQR) changes in SOFA score were -4 (-7 to 7) in the iloprost group and -5 (-8 to 5) in the placebo group (median difference, 1; 95% CI, 0-3; P = 0.12). At 28 days, 48 patients (42%) had died in the iloprost group and 47 (39%) had died in the placebo group (relative risk, 1.08; 95% CI, 0.80-1.5). The median average SOFA score was 11.2 (7.4-15.9) in the iloprost group, compared with 10.5 (6.8-16.5) in the placebo group (median difference, 0.25; 95% CI, -1.1 to 1.8). Median (95% confidence interval) between-group differences in 28-day ventilation-, vasopressor-, and renal replacement therapy-free survival days were 0 (0-0), 0 (-1 to 1), and 0 (0-0), respectively. Severe adverse events occurred in 15% of patients in the iloprost group and 7% of patients in the placebo group (P = 0.06). Conclusions: Among patients with septic shock and persistent hypoperfusion, iloprost did not reduce the severity of organ failure. Clinical trial registered with www.clinicaltrials.gov (NCT03788837) and EudraCT (2018-001709-10).

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Fichiers liés : 4f1a8b06aee7eed8d358546536d7a339.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Adrien Ter SchiphorstPierre SenersAnke WoutersNicole YuenMichael MlynashJeremy Josef HeitStephanie KempSøren ChristensenDenis SablotAnne WacongneThibault LaluAude PhilippeCaroline ArquizanVincent CostalatGregory W AlbersMaarten Lansberg
• Organismes : Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Stanford Stroke Center Institut de psychiatrie et neurosciences de Paris Institut de psychiatrie et neurosciences de Paris Stanford Stroke Center Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Catholic University of Leuven = Katholieke Universiteit Leuven Stanford Stroke Center Stanford Stroke Center Stanford University Stanford Stroke Center Stanford Stroke Center Centre Hospitalier Saint Jean de Perpignan Centre Hospitalier Universitaire de Nîmes Centre Hospitalier de Béziers Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Gui de Chauliac [CHU Montpellier] Institut de psychiatrie et neurosciences de Paris Département de Neuroradiologie [CHRU Montpellier] Institut de psychiatrie et neurosciences de Paris Stanford Stroke Center Stanford Stroke Center
• Publié dans Stroke le 31/10/2020

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Résumé : Background: For patients with acute ischemic stroke due to a large vessel occlusion admitted in primary stroke centers, helicopter transfer to comprehensive stroke centers is often used to expedite access to mechanical thrombectomy. Some studies have suggested that vibrations generated during helicopter transport might enhance intravenous thrombolysis (IVT) efficacy. We aimed to evaluate the impact of helicopter transfer, compared with ground transportation, on interhospital recanalization and functional outcomes. Methods: We conducted a retrospective analysis of 2 prospectively collected cohorts of anterior circulation acute ischemic stroke due to a large vessel occlusion patients transferred to 2 comprehensive stroke centers (Stanford, CA, November 2019 to January 2023, and Montpellier, France, January 2015 to January 2017) for mechanical thrombectomy consideration with arterial imaging both at the primary stroke center and on comprehensive stroke center arrival. The primary outcome was interhospital recanalization, determined by comparison of the baseline and posttransfer arterial imaging and defined as revised arterial occlusive lesion scores of 2b to 3. The association between transportation mode (helicopter versus ground) and interhospital recanalization was studied in logistic regression analysis, adjusting for pretransfer IVT use, occlusion site, and transfer duration. Results: Among 520 included patients, 315 (61%) were transferred by helicopter and 259 (50%) received IVT before transfer. Interhospital recanalization rates were similar between helicopter and ground transfers in both the overall cohort (23% versus 19%; P=0.30) and the IVT subgroup (36% versus 33%; P=0.61). Adjusted analyses confirmed no association between helicopter transport and interhospital recanalization (adjusted odds ratio, 1.23 [95% CI, 0.72-2.11]; P=0.44). Favorable 3-month functional outcome (modified Rankin Scale score, 0-2) rates were also similar between helicopter and ground transfers in both unadjusted (35% versus 40%; P=0.29) and adjusted analyses (adjusted odds ratio, 1.12 [95% CI, 0.67-1.88]; P=0.67). Conclusions: In this multicenter observational cohort study, helicopter transfer was not associated with improved interhospital recanalization or favorable functional outcomes compared with ground transport. These findings do not support the hypothesis that vibrations during helicopter transport enhance IVT efficacy.

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Fichiers liés : Ter Schiphorst Stroke 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Baptiste AbbarLabreche KarimJacques CadranelMarianne VeyriVéronique MorinFatou Seck ThiamNathalie DesireMarine BaronErell GuillermAlexandre PerrierVincent FalletThomas MaitreAnthony CanellasNadine TarantinoOulfata MzeAssia SamriLisa DejancourtCecilia Nakid-CorderoAurore VozyAlberto PiccaMehdi TouatAmélie GuihotChristos ChouaidKarima MokhtariFranck BielleIsabelle BrocheriouPhilippe RouvierAnita Rodenas OsorioDavid BuobAmira BouzidiYannick MarieJalal AssouadPierre-Yves BoëlleFlorence CouletVincent VieillardJean-Philippe SpanoBrigitte Autran
• Organismes : Centre d'Immunologie et des Maladies Infectieuses
• Publié dans Journal of Thoracic Oncology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Philippe RicaudPierre DurandPaolo GrigioniVirginia CiardiniMassimo del GuastaGiuseppe CamporealeJean-Luc AttiéEric Bazile
• Organismes : Centre national de recherches météorologiques Laboratoire d'aérologie Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development Istituto Nazionale di Ottica [Firenze] Laboratoire d'aérologie Centre national de recherches météorologiques
• Publié dans Polar Science le 02/11/2020

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Résumé : While the majority of Antarctic clouds are made up of ice crystals, a significant proportion consists of supercooled liquid water (SLW), defined as water in liquid form below 0 • C. Observations of SLW clouds have been carried out for several years at Dome C, the Concordia station (75 • S, 123 • E; 3233 m above mean sea level), combining observations from LIDAR, microwave radiometer and balloon-borne sondes. The present analysis is separated in two parts. Firstly, we will focus on the diurnal variation of the planetary boundary layer (PBL) from balloon-borne profile observations performed on January 23, 2023 establishing the presence of SLW clouds: 1) at the top of the PBL between the entrainment zone and the capping inversion layer, 2) higher up within a fossil layer, and 3) within the very cold stable boundary layer close to the surface as liquid fog. Secondly, from a statistical study covering several summer periods, we will show that SLW clouds are present from 400 to 600 m above ground level (agl) in the entrainment zone and within the stable boundary layer below 100 m agl where liquid fog can form, with temperatures from -25 • C to -35 • C and LWP (liquid water path, the vertically-integrated SLW content) less than 3.0 g m -2 .

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Fichiers liés : 1-s2.0-S1873965225000933-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Grace AdwaneMaarten LansbergSimon LiebartFrederique CharbonneauMaya SchwartzJeremy Josef HeitMichael MlynashDenis SablotAnne WacongneJean-Philippe DesillesVincent CostalatMichael ObadiaCarole HenryEric ManchonCaroline ArquizanGregory AlbersAdrien ter SchiphorstPierre Seners
• Organismes : Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Stanford University Stanford Stroke Center Hôpital Gui de Chauliac [CHU Montpellier] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Stanford University Stanford University Stanford University Centre Hospitalier Saint Jean de Perpignan Centre Hospitalier Universitaire de Nîmes Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital French-Clinical Research Infrastructure Network - F-CRIN [Lille] FHU NeuroVasc [Paris] Neuroradiologie [Hôpital Gui de Chauliac] Institut de Génomique Fonctionnelle Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier de Gonesse Hôpital Gui de Chauliac [CHU Montpellier] Institut de psychiatrie et neurosciences de Paris Stanford University Institut de psychiatrie et neurosciences de Paris Hôpital Gui de Chauliac [CHU Montpellier] Stanford University Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Stanford Stroke Center Institut de psychiatrie et neurosciences de Paris
• Publié dans International Journal of Stroke le 31/10/2020

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Résumé : Background: Patients with acute ischemic stroke and a large vessel occlusion admitted to non-endovascular capable centers frequently require inter-hospital transfer to a comprehensive stroke center (CSC) for thrombectomy. Data regarding arterial recanalization of patients with basilar artery occlusion (BAO) during transfer are lacking. Methods: We analyzed prospectively collected data of acute stroke patients with BAO transferred for consideration of thrombectomy to three CSCs (Rothschild Hospital, France; Montpellier Hospital, France; Stanford Hospital, USA) between 2016 and 2024, with arterial imaging at the referring hospital and on CSC arrival. Inter-hospital recanalization was assessed by comparison of the baseline and post-transfer arterial imaging and was defined as 2a-3 on the modified Thrombolysis In Cerebral Infarction (mTICI) scale. Independent predictors of inter-hospital recanalization were assessed using multivariable logistic regression analysis. Results: Overall, 228 patients were included: median age 71 years, the National Institutes of Health Stroke Scale (NIHSS) of 14, transfer time of 3.5 h, and 39% of patients received intravenous thrombolysis (IVT) before transfer. The primary reason for withholding IVT was late presentation. Inter-hospital BAO recanalization occurred in 15% of patients. Variables independently associated with inter-hospital BAO recanalization were IVT use (adjusted odds ratio (aOR) = 24.3, 95% confidence interval (CI) = 6.9-85.5, P < 0.01), distal BAO site (aOR = 2.9, 1.0-8.5, P = 0.05), lack of diabetes (aOR = 11.4, 1.4-93.2, P = 0.02), and non-atheromatous etiology (aOR = 6.6, 1.4-31.4, P = 0.02). BAO recanalization rates ranged from 1% in non-IVT-treated patients with proximal BAO to 45% in IVT-treated patients with distal BAO. Inter-hospital recanalization was associated with an increased odds of good functional outcome (odds ratio (OR) for 3-month modified Rankin Scale (mRS) = 0-2 = 3.3, 95% CI = 1.2-8.8, P = 0.02, adjusted for age, pre-stroke mRS, baseline NIHSS, Posterior Circulation Alberta Stroke Program Early Computed Tomography Score (pc-ASPECTS), IVT use, and onset-to-imaging time). Conclusions: BAO recanalization during inter-hospital transfer for thrombectomy occurred in 15% of patients and was associated with a favorable 3-month outcome. IVT use in the referring center was the primary modifiable factor associated with recanalization, yet its use remains low. Expanding IVT indications in primary stroke centers and developing new therapies that increase recanalization may improve outcomes.

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Fichiers liés : Adwane et al IJS 2025.pdf

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