Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Baptiste AbbarLabreche KarimJacques CadranelMarianne VeyriVéronique MorinFatou Seck ThiamNathalie DesireMarine BaronErell GuillermAlexandre PerrierVincent FalletThomas MaitreAnthony CanellasNadine TarantinoOulfata MzeAssia SamriLisa DejancourtCecilia Nakid-CorderoAurore VozyAlberto PiccaMehdi TouatAmélie GuihotChristos ChouaidKarima MokhtariFranck BielleIsabelle BrocheriouPhilippe RouvierAnita Rodenas OsorioDavid BuobAmira BouzidiYannick MarieJalal AssouadPierre-Yves BoëlleFlorence CouletVincent VieillardJean-Philippe SpanoBrigitte Autran
• Organismes : Centre d'Immunologie et des Maladies Infectieuses
• Publié dans Journal of Thoracic Oncology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Philippe RicaudPierre DurandPaolo GrigioniVirginia CiardiniMassimo del GuastaGiuseppe CamporealeJean-Luc AttiéEric Bazile
• Organismes : Centre national de recherches météorologiques Laboratoire d'aérologie Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development Istituto Nazionale di Ottica [Firenze] Laboratoire d'aérologie Centre national de recherches météorologiques
• Publié dans Polar Science le 02/11/2020

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Résumé : While the majority of Antarctic clouds are made up of ice crystals, a significant proportion consists of supercooled liquid water (SLW), defined as water in liquid form below 0 • C. Observations of SLW clouds have been carried out for several years at Dome C, the Concordia station (75 • S, 123 • E; 3233 m above mean sea level), combining observations from LIDAR, microwave radiometer and balloon-borne sondes. The present analysis is separated in two parts. Firstly, we will focus on the diurnal variation of the planetary boundary layer (PBL) from balloon-borne profile observations performed on January 23, 2023 establishing the presence of SLW clouds: 1) at the top of the PBL between the entrainment zone and the capping inversion layer, 2) higher up within a fossil layer, and 3) within the very cold stable boundary layer close to the surface as liquid fog. Secondly, from a statistical study covering several summer periods, we will show that SLW clouds are present from 400 to 600 m above ground level (agl) in the entrainment zone and within the stable boundary layer below 100 m agl where liquid fog can form, with temperatures from -25 • C to -35 • C and LWP (liquid water path, the vertically-integrated SLW content) less than 3.0 g m -2 .

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Fichiers liés : 1-s2.0-S1873965225000933-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2025
• Auteurs : Grace AdwaneMaarten LansbergSimon LiebartFrederique CharbonneauMaya SchwartzJeremy Josef HeitMichael MlynashDenis SablotAnne WacongneJean-Philippe DesillesVincent CostalatMichael ObadiaCarole HenryEric ManchonCaroline ArquizanGregory AlbersAdrien ter SchiphorstPierre Seners
• Organismes : Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Stanford University Stanford Stroke Center Hôpital Gui de Chauliac [CHU Montpellier] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Stanford University Stanford University Stanford University Centre Hospitalier Saint Jean de Perpignan Centre Hospitalier Universitaire de Nîmes Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital French-Clinical Research Infrastructure Network - F-CRIN [Lille] FHU NeuroVasc [Paris] Neuroradiologie [Hôpital Gui de Chauliac] Institut de Génomique Fonctionnelle Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Centre Hospitalier de Saint-Denis [Ile-de-France] Centre Hospitalier de Gonesse Hôpital Gui de Chauliac [CHU Montpellier] Institut de psychiatrie et neurosciences de Paris Stanford University Institut de psychiatrie et neurosciences de Paris Hôpital Gui de Chauliac [CHU Montpellier] Stanford University Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Stanford Stroke Center Institut de psychiatrie et neurosciences de Paris
• Publié dans International Journal of Stroke le 31/10/2020

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Résumé : Background: Patients with acute ischemic stroke and a large vessel occlusion admitted to non-endovascular capable centers frequently require inter-hospital transfer to a comprehensive stroke center (CSC) for thrombectomy. Data regarding arterial recanalization of patients with basilar artery occlusion (BAO) during transfer are lacking. Methods: We analyzed prospectively collected data of acute stroke patients with BAO transferred for consideration of thrombectomy to three CSCs (Rothschild Hospital, France; Montpellier Hospital, France; Stanford Hospital, USA) between 2016 and 2024, with arterial imaging at the referring hospital and on CSC arrival. Inter-hospital recanalization was assessed by comparison of the baseline and post-transfer arterial imaging and was defined as 2a-3 on the modified Thrombolysis In Cerebral Infarction (mTICI) scale. Independent predictors of inter-hospital recanalization were assessed using multivariable logistic regression analysis. Results: Overall, 228 patients were included: median age 71 years, the National Institutes of Health Stroke Scale (NIHSS) of 14, transfer time of 3.5 h, and 39% of patients received intravenous thrombolysis (IVT) before transfer. The primary reason for withholding IVT was late presentation. Inter-hospital BAO recanalization occurred in 15% of patients. Variables independently associated with inter-hospital BAO recanalization were IVT use (adjusted odds ratio (aOR) = 24.3, 95% confidence interval (CI) = 6.9-85.5, P < 0.01), distal BAO site (aOR = 2.9, 1.0-8.5, P = 0.05), lack of diabetes (aOR = 11.4, 1.4-93.2, P = 0.02), and non-atheromatous etiology (aOR = 6.6, 1.4-31.4, P = 0.02). BAO recanalization rates ranged from 1% in non-IVT-treated patients with proximal BAO to 45% in IVT-treated patients with distal BAO. Inter-hospital recanalization was associated with an increased odds of good functional outcome (odds ratio (OR) for 3-month modified Rankin Scale (mRS) = 0-2 = 3.3, 95% CI = 1.2-8.8, P = 0.02, adjusted for age, pre-stroke mRS, baseline NIHSS, Posterior Circulation Alberta Stroke Program Early Computed Tomography Score (pc-ASPECTS), IVT use, and onset-to-imaging time). Conclusions: BAO recanalization during inter-hospital transfer for thrombectomy occurred in 15% of patients and was associated with a favorable 3-month outcome. IVT use in the referring center was the primary modifiable factor associated with recanalization, yet its use remains low. Expanding IVT indications in primary stroke centers and developing new therapies that increase recanalization may improve outcomes.

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Fichiers liés : Adwane et al IJS 2025.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/06/2025
• Auteurs : Laurent MazenqPierre-François CalmonAdrian LabordeFranck CarcenacAurélie LecestreLudovic SalvagnacPascal DubreuilÉric ImbernonDavid BourrierHugues GranierLiviu NicuPhilippe MeniniGuilhem LarrieuPierre JosephMorgan Delarue
• Organismes : Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Laboratoire d'analyse et d'architecture des systèmes Équipe MICrosystèmes d'Analyse Équipe Matériaux et Procédés pour la Nanoélectronique Équipe Micro-Nanofluidique pour les sciences de la vie et de l'environnement Équipe Micro-Nanofluidique pour les sciences de la vie et de l'environnement

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Résumé : This presentation will show how established micro- and nanofabrication techniques contribute to progress in electronics, sensing technologies, and medical applications. After introducing the cleanroom environment, essential for controlling contamination and ensuring high-precision fabrication, it will highlight versatile processes for creating thin films, patterning materials, and defining structures at micro- and nanoscales.The talk will showcase advanced lithography and etching techniques that enable the miniaturization of components, unlocking new possibilities for high-performance devices. Examples of ongoing projects, such as the development of sensitive gas sensors for environmental and health applications, will illustrate the transition from fabrication processes to real-world solutions.Finally, an overview of current research will demonstrate how micro- and nanotechnologies are evolving to meet the demands of future applications, particularly in life sciences and cancer diagnostics, paving the way for smarter, more efficient, and more integrated devices.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/06/2025
• Auteurs : Mohamed Amine El YagoubyPhilippe MulhemJean-Pierre ChevalletÉric Gaussier
• Organismes : Laboratoire Lorrain de Recherche en Informatique et ses Applications Université de Lorraine Modélisation et Recherche d’Information Multimédia [Grenoble] Modélisation et Recherche d’Information Multimédia [Grenoble] Laboratoire d'Informatique de Grenoble Centre National de la Recherche Scientifique Laboratoire d'Informatique de Grenoble Université Grenoble Alpes Modélisation et Recherche d’Information Multimédia [Grenoble] Université Grenoble Alpes Laboratoire d'Informatique de Grenoble

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Résumé : Cet article introduit un nouveau cadre d'évaluation pour les systèmes RAG, en comblant les lacunes des approches précédentes. La première phase consiste à concevoir un ensemble de données avec des parties pertinentes extraites pour chaque exemple, représentant les informations nécessaires pour répondre à une question donnée, et à proposer une métrique d'évaluation pour les systèmes IR basée sur la présence de ces parties dans le contenu récupéré. La deuxième phase explore la relation entre le système de RI et les évaluations RAG globales et utilise cette relation pour prédire les performances globales du RAG à partir des performances du SRI. Cette approche élimine le besoin de réponses coûteuses générées par LLM et d'évaluations ultérieures, réduisant ainsi les coûts et fournissant un cadre d'évaluation plus complet et plus robuste pour les systèmes RAG.

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Fichiers liés : CORIA-TALN_2025_paper_153.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 27/06/2025
• Auteurs : Céline BoehmAlberto Krone-MartinsAntónio AmorimGuillem Anglada-EscudéAlexis BrandekerFrederic CourbinTorsten EnßlinAntónio FalcãoKatherine FreeseBerry HollLucas LabadieAlain LegerFabien MalbetGary MamonBarbara McarthurAlcione MoraMichael ShaoAlessandro SozzettiDouglas SpolyarEva VillaverConrado AlbertusStefano BertoneHervé BouyMichael Boylan-KolchinAnthony BrownWarren BrownVitor CardosoL. CheminRiccardo ClaudiAlexandre C.M. CorreiaMariateresa CrostaAntoine CrouzierFrancis-Yan Cyr-RacineMario DamassoAntónio da SilvaMelvyn DaviesPayel DasPratika DayalMiguel de Val-BorroAntonaldo DiaferioAdrienne ErickcekMalcolm FairbairnMorgane FortinMalcolm FridlundPaulo GarciaOleg GnedinAriel GoobarPaulo GordoRenaud GoullioudNigel HamblyNathan HaraDavid HobbsErik HogRodrigo A IbataCarme JordiSergei KlionerSergei KopeikinThomas LacroixJacques LaskarChristophe Le Poncin-LafitteXavier LuriSubhabrata MajumdarRichard MasseyRichard MasseyBertrand MennessonDaniel MichalikAndré Moitinho de AlmeidaLeonidas MoustakasLeonidas MoustakasNeil MurrayMatthew MuterspaughMicaela OertelLuisa OstoreroAngeles Perez-GarciaImants PlataisJord I Portell de MoraAndreas QuirrenbachLisa RandallJustin ReadEniko RegosBarnes RoryKrzysztof RybickiPat ScottJean SchneiderJakub ScholtzArnaud SiebertIsmael TerenoJohn TomsickWesley TraubMonica ValluriNicholas WaltonNicholas WaltonLaura WatkinsGlenn WhiteDafydd Wyn EvansLukasz WyrzykowskiRosemary WyseUmmi AbbasJean-Michel AlimiMartin AltmannJoão AlvesRichard AndersonFrédéric ArenouCoryn Bailer-JonesBaugh CarltonMichael BiermannSergi Blanco-CuaresmaAldo Stefano BonomoAvery BroderickGiorgia BussoJuan CabreraJosep Manel CarrascoCarla Sofia CarvalhoMarco CastellaniMarina Cermeño-GavilánPaula ChadwickJeremy DarlingMichael DavidsonFrancesca de AngeliReinaldo de CarvalhoSilvano DesideraChris DoneChristine DucourantDenis ErkalLaurent EyerBenoit FameySofia FeltzingEmilio Fraile GarciaFacundo Ariel GomezCarlos FrenkLaurent GalluccioPhillip GalliLaurent GalluccioPanagiotis GavrasPaolo GiacobbeAriel GoobarRaffaele GrattonFabrizia GuglielmettiEike GuntherDavid HallDiana HarrisonArtie HatzesDaniel HestrofferEmille IshidaPascale JablonkaChristopher JacobsMathilde JauzacJens JascheMathilde JauzacHugh JonesJean-Paul KneibFrancesc JulbeJean-Paul KneibGeorges KordopatisArianne LanconMario Gilberto LattanziJean-Michel LeguidouMatt LehnertHarry LehtoIlidio LopesNicolas F. MartinMarcella MarconiNicolas MartinMaury Marie-ElisabethAnupam MazumdarTatiana MichtchenkoStefano MinardiCarlos MunozGiuseppe MuranteIsabella PaganoOrtwin GerhardIsabella PaganoPaolo PaniGiampaolo PiottoPfenniger DanielGiampaolo PiottoOlivier PreisNicolas ProduitSean N. RaymondHeike RauerSean RaymondRosa ReinaldoYves RevazRibeiro RitaLorenzo RimoldiniArnau Rios HuguetVincenzo RipepiPier-Francesco RocciMaria D. Rodriguez FriasReinaldo R. RosaJohannes SahlmannIppocratis SaltasJosé Pizarro Sand E E LemosLuis M. SarroBjörn Malte SchäferJascha SchewtschenkoDamien SégransanFranck SelsisJoe SilkManuel SilvaFilomena SolitroAlessandro SpagnaVolker SpringelMaria SüvegesRamachrisna TeixeiraTetsuo ShindouPhilippe ThebaultFeng TianCatherine TuronJosé W.F. ValleEugene VasilievJuan VladiloVollmann MartinMartin WardJochen WellerMark WilkinsonSebastian WolfFu XiaotingYoshiyuki YamadaSven ZschockeShay Zucker
• Organismes : Institut d'astrophysique spatiale Université Grenoble Alpes Institut d'Astrophysique de Paris Observatoire de Paris - Site de Paris Institut de Mécanique Céleste et de Calcul des Ephémérides Université de Strasbourg Institut d'Astrophysique de Paris Institut de Mécanique Céleste et de Calcul des Ephémérides Observatoire de Paris - Site de Meudon Laboratoire Univers et Théories Observatoire de Paris - Site de Meudon Observatoire astronomique de Strasbourg Observatoire de Paris - Site de Meudon Galaxies, Etoiles, Physique, Instrumentation Laboratoire d'Astrophysique de Bordeaux [Pessac] Université de Strasbourg Observatoire de la Côte d'Azur Institut de Mécanique Céleste et de Calcul des Ephémérides Université Blaise Pascal - Clermont-Ferrand 2 Université de Strasbourg Centre National d’Études Spatiales [Paris] Institut d'Astrophysique de Paris Université de Strasbourg Joseph Louis LAGRANGE Laboratoire d'Astrophysique de Bordeaux [Pessac] Joseph Louis LAGRANGE Laboratoire d'Astrophysique de Bordeaux [Pessac] Institut d'Astrophysique de Paris Observatoire de Paris - Site de Paris Galaxies, Etoiles, Physique, Instrumentation

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Résumé : In the context of the ESA M5 (medium mission) call we proposed a new satellite mission, Theia, based on relative astrometry and extreme precision to study the motion of very faint objects in the Universe. Theia is primarily designed to study the local dark matter properties, the existence of Earth-like exoplanets in our nearest star systems and the physics of compact objects. Furthermore, about 15 $\%$ of the mission time was dedicated to an open observatory for the wider community to propose complementary science cases. With its unique metrology system and "point and stare" strategy, Theia's precision would have reached the sub micro-arcsecond level. This is about 1000 times better than ESA/Gaia's accuracy for the brightest objects and represents a factor 10-30 improvement for the faintest stars (depending on the exact observational program). In the version submitted to ESA, we proposed an optical (350-1000nm) on-axis TMA telescope. Due to ESA Technology readiness level, the camera's focal plane would have been made of CCD detectors but we anticipated an upgrade with CMOS detectors. Photometric measurements would have been performed during slew time and stabilisation phases needed for reaching the required astrometric precision.

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Fichiers liés : 1707.01348v1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/06/2025
• Auteurs : Mathilde BoussacF. FaggianelliEstelle HarrochAlexandre EusebioMargherita FabbriFabienne Ory MagneEmeline DescampsOlivier J. RascolChloé LaurencinAna MarquesMathieu AnheimBruno GiordanaLucie HopesCaroline MoreauAnne Sophie RollandDavid DevosDavid MaltêteSolène AnsquerElodie HainqueSophie DrapierJean-Philippe BrandelTiphaine RouaudDominique GuehlBéchir JarrayaFazia Mélissa TirTatiana WitjasJean-Philippe AzulayChristine Brefel-Courbon
• Organismes : Toulouse NeuroImaging Center Hôpital de la Timone [CHU - APHM] Centre d'investigation clinique de Toulouse Centre Hospitalier Universitaire de Toulouse Institut de Neurosciences de la Timone Hôpital de la Timone [CHU - APHM] Toulouse NeuroImaging Center Département Neurologie [CHU Toulouse] Centre d'investigation clinique de Toulouse Toulouse NeuroImaging Center Centre National de la Recherche Scientifique Toulouse NeuroImaging Center Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Équipe Pathophysiologie de la maladie de Parkinson et des troubles associés - Pathophysiology of Parkinson's disease and related disorders Team CHU Clermont-Ferrand Institut Pascal Thérapie guidée par l'image Service de Neurologie [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Institut de Génétique et de Biologie Moléculaire et Cellulaire Hôpital Pasteur [Nice] Centre Hospitalier Régional Universitaire de Nancy Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Département de Pharmacologie Médicale [Lille] Département de neurologie [Lille] CHU Rouen CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) AP-HP - Hôpital de la Pitié Salpêtrière Institut du Cerveau = Paris Brain Institute Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] AP-HP. Sorbonne Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Bordeaux Institut des Maladies Neurodégénératives [Bordeaux] Institut National de la Santé et de la Recherche Médicale Université Paris-Saclay Commissariat à l'énergie atomique et aux énergies alternatives Université de Versailles Saint-Quentin-en-Yvelines Hôpital Foch [Suresnes] Centre Hospitalier Universitaire d'Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Institut de Neurosciences de la Timone Institut de Neurosciences de la Timone Toulouse NeuroImaging Center Centre d’Excellence en Maladies Neurodégénératives
• Publié dans Journal of Parkinson's disease le 29/10/2020

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Résumé : Background: Parkinson's disease (PD) patients on dopaminergic drugs may experience non-motor fluctuations (NMFs) which are often heterogeneous and respond variably to treatments. Objective: We evaluated if personality was associated to NMFs and could modulate the NMFs responsiveness to dopaminergic medication and deep brain stimulation of the sub-thalamic nucleus (STN-DBS). Methods: From the PREDISTIM cohort, personality dimensions of 235 PD patients were assessed by the Temperament and Character Inventory (TCI) before STN-DBS (V0). NMFs were evaluated using the NMFs Severity Scale at V0 and one year after STN-DBS (V1). Linear regression models were performed between TCI dimensions and NMFs at V0; and logistic regression models were done between TCI dimensions and 1) groups of dopa-sensitive patients (responders to ON medication at V0) versus non-dopa-sensitive ones, and 2) responders versus non-responders to STN-DBS at V1. Odds ratios (OR) were also calculated. Results: Significant associations were found between two TCI personality dimensions (“Harm Avoidance” and “Self-Directedness”) and severity of NMFs in OFF medication at V0: PD patients with higher Harm Avoidance and lower Self-Directedness scores having more NMFs. TCI personality dimensions were not associated with the dopa-sensitivity while Novelty Seeking was significantly associated with the STN-DBS-responder group for the psychiatric (OR = 1.09 [1.02–1.17]) and for the dysautonomic NMFs (OR = 1.11 [1.04–1.18]). Conclusions: Certain personality dimensions (Harm Avoidance and Self-Directedness) are associated with NMFs severity at baseline, and PD patients with high Novelty Seeking seem to be better candidates for NMFs improvement after STN-DBS. Plain Language SummaryNon-motor fluctuations are highly invalidating for patients with Parkinson's disease and their response to treatments is variable. This new research examined personality dimensions impact on non-motor fluctuations and their responsiveness to dopaminergic medication and to deep brain stimulation. Two hundred and thirty-five patients with Parkinson's disease participated in the study and filled out several questionnaires to score their personality dimensions and their non-motor fluctuations severity before and after one year of deep brain stimulation. Comparisons were done between different groups of patients according to their response to dopaminergic treatments and to deep brain stimulation. As results, patients with personality traits of high “Harm Avoidance” (more anxious individuals) and low “Self-Directedness” (less goal-oriented individuals) had globally more non-motor fluctuations, and the personality dimension of “Novelty Seeking” (impulsive individuals) was related to a better non-motor fluctuations responsiveness to deep brain stimulation. Hence, non-motor fluctuations are associated with some specific personality dimensions on top of early onset of Parkinson's disease, long disease-duration, high doses of levodopa and female gender. Moreover, Parkinson's disease patients with impulsive-like personality seem to be better candidates for non-motor fluctuations improvement after deep brain stimulation.

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Fichiers liés : boussac-et-al-2025-exploring-the-link-between-personality-dimensions-and-non-motor-fluctuations-in-parkinson-s-disease.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/06/2025
• Auteurs : Oksana SaccaviniRebecca HibbardPhilippe BrauneisenMattias DelpontJean-Pierre VaillancourtMathilde C. Paul
• Organismes : Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Université de Montréal Interactions hôtes-agents pathogènes [Toulouse]

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• Type de publi. : Article dans une revue
• Date de publi. : 26/06/2025
• Auteurs : Delphine DouilletAlexandre GodonGeoffroy RousseauStéphanie RuizFanny VardonEmmanuel de MaistreDelphine GarrigueIsabelle Gouin-ThibaultYves GruelJulien LanoiseléeFrédéric LapostolleDominique LasneAlexandre MansourAnne-Céline MartinMikaël MazighiPatrick MismettiThomas MoumnehFarès MoustafaAndrea PenalozaStéphanie RoulletPierre-Marie RoyVirginie SiguretJeannot SchmidtCharles TacquardKarim TazarourtePaul ZuffereyPhilippe NguyenAnne Godier
• Organismes : MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire d'Angers CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier Régional Universitaire de Tours Pôle Anesthésie Réanimation [CHU de Toulouse] Pôle Anesthésie Réanimation [CHU de Toulouse] Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Membrane Signalling and Inflammation in reperfusion Injuries Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] U 1059 – SAINBIOSE Bio-ingénierie Assistance publique - Hôpitaux de Paris AP-HP - Hôpital Avicenne Marqueurs cardiovasculaires en situation de stress Assistance publique - Hôpitaux de Paris Hémostase, Inflammation, Thrombose AP-HP - Hôpital Necker - Enfants Malades Centre Hospitalier Universitaire [Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis AP-HP - Hôpital Européen Georges Pompidou Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Service de neurologie [Univ. Paris VII] Optimisation thérapeutique en Neuropsychopharmacologie Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] U 1059 – SAINBIOSE Bio-ingénierie Éducation Éthique Santé Centre Hospitalier Régional Universitaire de Tours CHU Clermont-Ferrand Unité de Nutrition Humaine Cliniques Universitaires Saint-Luc [Bruxelles] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Hémostase, Inflammation, Thrombose Centre Hépato-Biliaire [Hôpital Paul Brousse] Assistance publique - Hôpitaux de Paris F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Universitaire d'Angers MitoVasc - Équipe CarME (Cardiovascular Pathophysiology) AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis Laboratoire de Psychologie Sociale et Cognitive Établissement Français du Sang Grand-Est [Strasbourg] Centre Hospitalier Universitaire [Strasbourg] Research on Healthcare Performance Hospices Civils de Lyon U 1059 – SAINBIOSE Bio-ingénierie Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital universitaire Robert Debré [Reims] Pharmacologie et Pathologies Fragilisantes Université Paris Cité AP-HP - Hôpital Européen Georges Pompidou
• Publié dans Anaesthesia Critical Care & Pain Medicine le 27/10/2020

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Résumé : Objective: The Soci & eacute;t & eacute; Fran & ccedil;aise de M & eacute;decine d'Urgence (SFMU), the Soci & eacute;t & eacute; Fran & ccedil;aise d'Anesth & eacute;sie et de R & eacute;animation (SFAR), the Groupe d'Int & eacute;r & ecirc;t en H & eacute;mostase P & eacute;ri-op & eacute;ratoire (GIHP) and the Soci & eacute;t & eacute; Fran & ccedil;aise de Thrombose et d'H & eacute;mostase (SFHT) have collaborated to propose a set of guidelines on the management of anticoagulants in an emergency setting. Design: A group of French and Belgian experts from the French Societies of Emergency Medicine (SFMU), Anaesthesia and Intensive Care (SFAR), the working group on Perioperative Haemostasis (GIHP) and the French Society of Thrombosis and Haemostasis (SFHT) was convened. Any potential conflicts of interest were officially declared at the start of the recommendation development process, which was conducted independently of any industry funding. The authors used the GRADE ("Grading of Recommendations Assessment, Development and Evaluation") methodology to assess the level of evidence in the literature. Methods: Five areas were defined: (1) The role of laboratory testing in determining anticoagulant use and the level of anticoagulation; (2) Management of anticoagulant-associated bleeding; (3) Management of asymptomatic overdoses; (4) Management of non-elective invasive procedures on anticoagulants; and (5) Thrombolysis for acute ischaemic stroke on anticoagulants. For each field, the aim of the recommendations was to answer a certain number of questions formulated by the experts according to the PICO model ("Population, Intervention, Comparison, Outcome"). Based on these questions, an extensive bibliographic search from 1990 onwards was carried out using predefined key words according to the PRISMA recommendations. Data quality was analysed using the GRADE method. Recommendations were formulated using the GRADE method and then voted on by all the experts using the GRADE grid method. Results: The experts' summary work and application of the GRADE method resulted in 103 recommen-dations concerning 21 questions. After two rounds of voting and several amendments, strong agreement was reached on 97 recommendations. Out of these recommendations, 19 have a high level of evidence (19 GRADE 1), 35 have a low level of evidence (35 GRADE 2), and 48 are expert opinions. Finally, for one question, no recommendation could be made. Conclusions: There was strong agreement among the experts to provide recommendations for clinicians to provide up-to-date management of patients on anticoagulants in an emergency setting. 2025 Published by Elsevier Masson SAS on behalf of Soci & eacute;t & eacute; Fran & ccedil;aise d'Anesth & eacute;sie et de R & eacute;animation (SFAR).

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• Type de publi. : Article dans une revue
• Date de publi. : 25/06/2025
• Auteurs : Romaric LacroixCoralie JudiconeKarim Harti SouabAmandine BonifayAnderson LoundouTarik BouricheSylvie CointeLoris VallierEvelyne AbdiliLaurent ArnaudStéphane RobertPhilippe PonceletCharlotte GrosdidierPierre MorangeEva Cochery-NouvellonSylvie BouvierJean-Christophe GrisJean‐yves LefrantMarc LeoneJacques AlbaneseFrançoise Dignat‐george
• Organismes : Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Assistance Publique - Hôpitaux de Marseille Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Laboratoire de glaciologie et géophysique de l'environnement Laboratoire de Spectrométrie Ionique et Moléculaire Institut des Géosciences de l’Environnement Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Institut Desbrest d'Epidémiologie et de Santé Publique Service d'Hématologie [CHRU Nîmes] Université de Montpellier Institut Desbrest d'Epidémiologie et de Santé Publique Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
• Publié dans Journal of Extracellular Vesicles le 27/10/2020

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Résumé : Septic shock is characterised by abnormal coagulation activation with defective fibrinolysis, leading to a high mortality rate. Cellular activation triggers the release of extracellular vesicles (EVs) conveying both procoagulant and fibrinolytic activities. We investigated whether the balance between these activities, termed EV‐coagulolytic balance (EV‐CLB), predicts day‐90 mortality in 225 septic shock patients included in a multicentre prospective study. EV‐CLB, quantified as a ratio of TF‐dependent thrombin generation to uPA‐dependent plasmin generation, was higher in non‐survivors than in survivors at 24 h (2.78 [0.86–16.1] a.u. vs. 0.97 [0.34–2.18] a.u., p < 0.001). Moreover, survivors showed a significant decrease in EV‐CLB from H0 to H48 in contrast to non‐survivors. EV‐CLB was a better predictor than EV‐associated–procoagulant and ‐fibrinolytic activities taken individually and better correlated with sepsis severity markers such as SAPS II and lactate levels. Multivariate Cox regression models including severity markers and comorbidities confirmed EV‐CLB as an independent predictor of mortality in septic shock patients. Interestingly, subgroup analysis revealed EV‐CLB's strong prognostic value in peritonitis, biliary and urinary tract infections and Gram‐negative sepsis. Despite challenges in EV measurement requiring technical advancement for clinical translation, EV‐CLB represents a potential novel biomarker to guide individualised therapy targeting coagulation/fibrinolysis imbalance in septic shock. Trial Registration : This trial was registered at ClinicalTrials.gov identifier: NCT02062970

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Fichiers liés : J of Extracellular Vesicle - 2025 - Lacroix - The Procoagulant and Fibrinolytic Balance of Extracellular Vesicles Predicts.pdf

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