Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 16/06/2025
• Auteurs : O. CopieJulien VarignonIngrid Cañero InfanteMariam MartirosyanFadi ChoueikaniPhilippe OhresserP.-E. JanolinAlain PautratAdrian DavidPhilippe GhosezWilfrid Prellier
• Organismes : Institut Jean Lamour Laboratoire de cristallographie et sciences des matériaux INL - Dispositifs Electroniques Institut Jean Lamour Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire Structures, Propriétés et Modélisation des solides Laboratoire de cristallographie et sciences des matériaux Laboratoire de cristallographie et sciences des matériaux Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire de cristallographie et sciences des matériaux
• Publié dans Physical Review Materials le 01/11/2020

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Fichiers liés : 2503.21327v1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/06/2025
• Auteurs : Anne-Charlotte ArnoldHenrique Fagundes GasparotoJean-Philippe BrunetPedro Juan Soto VegaPierre Violante
• Organismes : ETNA Sea-Robots Autonomous Robots Vision et Analyse de Données Autonomous Robots

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Résumé : Drones, used across various civilian and military sectors, are rapidly proliferating, but their current simulators and controllers lack flexibility and interoperability, hindering innovation-particularly for multi-agent systems and marine or underwater environments. This state-of-the-art review examines existing simulators and controllers to identify their strengths and weaknesses, assessing aspects such as realism, modularity, and hardware compatibility. This issue is even more pronounced in the case of marine drones. Solutions such as AirSim (realistic simulation using Unreal Engine) and UGCS (multi-drone mission management) represent significant progress, yet remain limited in modularity. Open-source SDKs like Dronecode SDK and MAVSDK allow for greater customization but require advanced technical skills. Moreover, user interface ergonomics remains a key challenge for broad adoption. Finally, integrating Green IT principles is becoming essential to reduce the environmental footprint of simulations. To meet growing demands, future software must deliver increased realism, multi-agent compatibility, and intuitive interfaces, ensuring both performance and sustainability.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 12/06/2025
• Auteurs : Anaïs FléchetPhilippe GumplowiczJean-Pierre Thibaudat
• Organismes : Laboratoire interdisciplinaire en études culturelles Centre d'Histoire Culturelle des Sociétés Contemporaines Université d'Évry-Val-d'Essonne Synergies Langues Arts Musique

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• Type de publi. : Article dans une revue
• Date de publi. : 11/06/2025
• Auteurs : Séverine MartiPhilippe PelletBlandine BeaupainLéa DurixJulien BurattiYves RéguerreNathalie AladjidiSaba AzarnoushSeverine ClauinWahid Abou ChahlaGilles BlaisonJeremy BertandDamien BodetBenoit BrethonJessica Chane-TengManon DelafoyChrystelle DuprazVirginie GandemerPhilippe DenizeauAlice GoldenbergPierre HirschAnaïs l'HaridonAude Marie-CardineGabriella VeraBrigitte NelkenLaure NizeryMarie NollaMarlène PasquetJérémie RosainLouis TerriouIsabelle PloJean DonadieuChristine Bellanné-Chantelot
• Organismes : Cellules souches hématopoïétiques et développement des hémopathies myéloïdes Cellules souches hématopoïétiques et développement des hémopathies myéloïdes Cellules souches hématopoïétiques et développement des hémopathies myéloïdes
• Publié dans HemaSphere le 26/10/2020

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Résumé : Abstract Congenital neutropenia (CN) comprises a heterogeneous group of rare genetic disorders. While some CN cases present only with neutropenia, others present with additional extra‐hematological manifestations. The most common cause of CN is variants in ELANE ; however, approximately 30 other genes have been implicated. Despite this, the genetic basis remains unknown in roughly 30% of cases. The clinical and genetic heterogeneity of CN makes diagnosis particularly challenging. To address this, we conducted exome or genome sequencing of 60 patients with a suspected diagnosis of CN that remained unresolved following targeted sequencing. A genetic diagnosis was established in 25 patients (42%). Variants were identified in 15 different genes. Half of these cases involved genes traditionally associated with hereditary immunodeficiencies ( GINS4 , CARD11 , ADA2 , GINS1 , LCP1 , SASH3 , and WAS ). One‐third of the cases carried variants in genes linked to syndromic disorders ( VPS13B , TAFAZZIN , CLPB , and TONSL ), demonstrating variable penetrance of extra‐hematological phenotypes. A smaller subset (15%) harbored variants in genes associated with inherited bone marrow failure syndromes ( BLM , RPL18 , SAMD9 , and SRP72 ), identified incidentally due to atypical presentations. Compared to patients with ELANE‐CN, these individuals were diagnosed later, had fewer severe bacterial infections and gingivitis, exhibited less profound neutropenia, lacked monocytosis, and had a granulocytic maturation arrest, often beyond the promyelocytic stage. A shared feature among these cases was a tendency toward reduced lymphocyte subsets, particularly NK cells. This study highlights the significant contribution of exome and genome sequencing in diagnosing CN, given the phenotypic overlap, genetic heterogeneity, and variable penetrance of immunological and extra‐hematological features.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/06/2025
• Auteurs : Pierre BayÉtienne AudureauSlim FouratiNicolas de ProstSébastien PréauRaphaël FavoryAurélie GuigonNicholas HemingElyanne GaultTài PhamAmal ChaghouriMatthieu TurpinLaurence Morand-JoubertSébastien JochmansAurélia PitschSylvie MeirelesDamien ContouAmandine HenryAdrien JosephMarie-Laure ChaixFabrice UhelDamien RouxDiane DescampsMalo EmeryClaudio Garcia-SanchezDavid LevySonia BurrelJulien MayauxAntoine KimmounCédric HartardFrédéric PèneFlore RozenbergStéphane GaudrySégolène BrichlerAntoine GuillonLynda HandalaFabienne TamionAlice MoisanThomas DaixSébastien HantzFlora DelamaireV. ThibaultBertrand SouweineCecile HenquellLucile PicardFrançoise BotterelChristophe RodriguezArmand Mekontso DessapJean-Michel PawlotskyKeyvan RazaziRaphaël BellaïcheElie AzoulayJean-François TimsitGuillaume VoiriotNina de MontmollinStéphane MarotDjeneba Bocar FofanaCharles-Edouard LuytDjillali AnnaneFerhat MezianiLouis-Marie JandeauxSamira Fafi-KremerCédric DarreauJean ThominAnaïs DartevelSylvie LarratEvelyne SchvoererCédric HartardBéatrice La CombeSéverine HaouiseeSami HraeichPierre-Edouard FournierPhilippe ColsonEmmanuel CanetBerthe Marie ImbertGuillaume ThierySylvie PilletRémy CoudroyNicolas LevequeClément SaccheriValérie GiordanengoKada KloucheEdouard TuaillonCécile AubronAdissa TranJean-Marc TadiéJean-Christophe PlantierSophie Vallet
• Organismes : Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) AP-HP - Hôpital Henri-Mondor IMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] Assistance publique - Hôpitaux de Paris Institut Mondor de Recherche Biomédicale AP-HP - Hôpital Henri-Mondor Institut Mondor de Recherche Biomédicale Assistance publique - Hôpitaux de Paris Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) IMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil] coVAPid Study Group coVAPid Study Group Laboratoire de Virologie - ULR 3610 Infection et inflammation AP-HP - Hôpital Raymond Poincaré AP-HP - Hôpital Ambroise Paré Assistance publique - Hôpitaux de Paris UFR Sciences de la santé Simone Veil Centre de recherche en épidémiologie et santé des populations AP-HP - Hôpital Bicêtre [Le Kremlin-Bicêtre] AP-HP - Hôpital Paul Brousse AP-HP - Hôpital Tenon Assistance publique - Hôpitaux de Paris Sorbonne Universités (COMUE) Institut National de la Santé et de la Recherche Médicale Centre hospitalier Marc Jacquet (Melun) Centre hospitalier Marc Jacquet (Melun) AP-HP - Hôpital Ambroise Paré coVAPid Study Group Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre de Recherche des Cordeliers Métabolisme, Cancer et Immunité AP-HP - Hôpital Saint-Louis [Paris] Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) AP-HP - Hôpital Louis Mourier UFR Médecine [Santé] - Université Paris Cité Institut Necker Enfants-Malades Physiopathologie et biothérapies des infections muqueuses [CIRI] Service des Agents Infectieux et Hygiène [CHU Saint-Etienne]
• Publié dans Critical Care le 31/10/2020

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Fichiers liés : s13054-025-05473-w.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 10/06/2025
• Auteurs : Aurélien PalmyreFairouz KoraichiFlavie AderErwan DonalCéline BordetPascal de GrooteLaurence FaivrePatricia RéantAnnick ToutainKarine NguyenBertrand IsidorAnne-Claire BrehinLise LegrandEstelle GandjbakhchJulie ProukhnitzkyRichard IsnardNicolas MansencalJean-François PrunyJean-Pierre RabesBruno FrancouCatherine CaillaudPascale RichardPhilippe Charron
• Organismes : Laboratoire Traitement du Signal et de l'Image Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases AP-HP - Hôpital de la Pitié Salpêtrière Centre de Référence des Cardiomyopathies et des Troubles du Rythme Cardiaque Héréditaires ou Rares [Boulogne-Billancourt] Sorbonne Université AP-HP - Hôpital Ambroise Paré
• Publié dans Orphanet Journal of Rare Diseases le 27/10/2020

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Résumé : Abstract Background Diagnostic work-up of patients with hypertrophic cardiomyopathy is crucial for appropriate management. However, the optimal genetic strategy remains debatable. We compared two strategies: targeted testing based on careful examination of clinical red flags versus large multigene panel analysis without gene prioritization. We applied the strategy to the diagnosis of Fabry disease or Hereditary Transthyretin Amyloidosis ( GLA or TTR genes respectively). Results We studied 341 hypertrophic cardiomyopathy index patients. Patients of subgroup 1 (n = 42) had careful clinical analysis and high suspicion of Hereditary Transthyretin Amyloidosis or Fabry disease. They underwent targeted Sanger sequencing. Patients in subgroup 2 (n = 299) did not have clinical selection, and underwent next-generation sequencing analysis of 107 cardiac genes. The yield of genetic testing for pathogenic/likely pathogenic variants in GLA and/or TTR was 28.6% in subgroup 1 (12/42: 5 TTR and 7 GLA ) versus 1.0% in subgroup 2 (3/299: 1 TTR and 2 GLA ), p < 0.01. Genetic results were obtained after a median of 26.0 days [IQR = 18–59.8] in subgroup 1 versus 193.5 days [IQR = 174–218] in subgroup 2, p < 0.01. Finally, genetic testing cost was 615.60€ or 769.50€ for TTR or GLA targeted analysis respectively, versus 1503.90€ for multigene panel analysis. Conclusions Both molecular strategies in hypertrophic cardiomyopathy patients are useful for the identification of pathogenic/likely pathogenic variants in TTR/GLA genes. However, targeted genetic testing based on clinical red flags identified causal mutations more efficiently, faster and at a lower cost. Careful clinical analysis is therefore important in guiding molecular strategy and may reduce diagnostic wandering and accelerate delivery of appropriate therapy.

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• Type de publi. :
• Date de publi. : 05/06/2025
• Auteurs : Oksana SaccaviniRebecca HibbardPhilippe BrauneisenMattias DelpontJean-Pierre VaillancourtMathilde C. Paul
• Organismes : Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal Interactions hôtes-agents pathogènes [Toulouse]

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Résumé : Biosecurity approaches have traditionally been implemented at the individual farm level. However, in light of major outbreaks of highly pathogenic avian influenza in the French poultry sector in recent years, individually-framed approach to biosecurity have become increasingly insufficient to control disease risks for farms that are epidemiologically interconnected through geographic proximity, shared equipment, personnel or animals. An alternative approach is to consider biosecurity more collectively at the level of a functional or geographic territory defined by shared risks. This study implemented a participatory approach to help farmers conceptualize biosecurity collectively, and to assess the approach’s impact on relationship dynamics within farmers’ communities. Individual interviews and four participatory workshops were designed to (1) identify shared motivations, values, and needs within communities, (2) identify shared risk factors, (3) foster understanding of epidemiological risks through expert discussions, and (4) identify collective, context-adapted solutions. Two farming communities in France were identified, consisting of seven and nine stakeholders, mainly chicken and duck farmers, from diverse production systems. Data were collected throughout the research process using full recording and transcription of the workshops. The results suggested that farmers’ shared values prioritized autonomy and quality of production, and that farmers perceived risks such as wildlife and wind transmission as major concerns over which they felt powerless to act. This study also highlighted the difficulty of engaging all stakeholders in collective biosecurity management. However, the participatory process generated enthusiasm. Many farmers, disillusioned by top-down biosecurity policies, welcomed a more inclusive, context-sensitive approach. The findings emphasized the role of key farmers as “pivot stakeholders” who can engage their peers and facilitate the shift towards a territorial-scale biosecurity strategy. The follow-up of farmers’ communities over a longer time frame should provide new insights on the collective actions which can be implemented by farmers as a group to manage infectious diseases.

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Fichiers liés : SACCAVINI - Towards collective biosecurity a participatory approach in French communities of poultry farmers.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/06/2025
• Auteurs : Jean-Philippe JennyCécilia BarouilletIsabelle DomaizonDavid EtienneIrene Gregory-EavesOlivia Itier-DesguéAndrea LamiErwan MessagerPierre SabatierJulie Rotschi
• Organismes : Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques McGill University = Université McGill [Montréal, Canada] Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques CNR Water Research Institute Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques
• Publié dans Journal of Paleolimnology le 25/10/2020

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Résumé : Cultural eutrophication has contributed to enhanced phytoplankton biomass in lakes around the world, leading to an overall increase in sedimentary carbon (C) sequestration since the twentieth century. However, the effects of land-use changes and restoration initiatives on sedimentary C sequestration are not yet well understood. To address this gap, we applied the paleolimnological approach to a temperate, hardwater site, Lake Aiguebelette, to investigate temporal changes in organic and inorganic C sequestration in relation to changes in C supplies, lake primary production, and preservation conditions over the past 300 years. Our results show that C sequestration has constantly increased in Lake Aiguebelette over the last 150 years due to local human disturbances. A first increase in lake-carbon sequestration was recorded between 1850 and the 1860s, a period marked by deforestation, marsh drainage, and lakelevel regulation — activities that collectively accelerated carbonate supply and precipitation in the lake. Subsequently, lake organic biomass production exceeded inorganic supplies and became the main contributor to total C sequestration. A period of nutrient enrichment in lake waters spanned from the 1950s to the1990s, which coincided with increased lake biomass and reduced hypolimnetic oxygen conditions. Over the last three decades, C sequestration has continued to increase, despite the reduction in nutrient loads following restoration measures. Our results suggest a long history of human disturbances, leading to a succession of perturbations in the carbon cycle in Lake Aiguebelette that favored C supplies and C fixation. In contrast, recent C burial appears to be controlled by decreased bottom-water oxygen conditions, despite improvements in surface-water quality. Overall, our study highlights a range of processes that can influence C burial over time, with recent reductions in nutrient loading during an era of climate warming resulting in both improved water quality and enhanced C storage.

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Fichiers liés : 10933_2025_358_Author.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/06/2025
• Auteurs : Maxence JamesJacques TrouverieAnne MarmagneFabien ChardonJulie FrémontPhilippe EtienneCéline Masclaux‐daubresse
• Organismes : Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay
• Publié dans Annals of Botany le 01/11/2020

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Résumé : Macroautophagy is essential for the degradation and recycling of various macromolecules in eukaryotic cells. In plants, autophagy is involved in the degradation of damaged chloroplasts in response to stress. Autophagy is a key player in nitrogen management at the whole-plant level, and autophagy mutants display strong defects in nitrogen remobilization and early leaf senescence phenotypes, especially during nitrogen source limitation. It is known that leaf senescence is associated with nutrient remobilization processes and is induced by nitrate limitation. However, it remains to be determined which actors are involved in this interplay and whether nutrient remobilization acts as a signal that enhances leaf senescence or whether senescence-associated chloroplast degradation promotes nutrient remobilization. In this context, our aim was to demine whether the level of autophagic activity controls leaf longevity and influences the progress of leaf senescence, balancing resources and waste management. Methods In this study, we used Arabidopsis autophagy knock-out mutants (atg) and plants overexpressing autophagy-associated genes (ATG8-OE) to compare their phenotypes with wild-type in both nitrate-sufficient conditions and nitrate starvation. Key Results The transfer from nitrate-sufficient conditions to nitrate starvation accelerated leaf senescence in all the genotypes. Unexpectedly, in both nitrate-sufficient and nitrate-starved conditions, both atg mutants and ATG8 overexpressors exhibited earlier leaf senescence phenotypes compared with wild-type. Given that autophagy is a longevity factor, the more severe leaf senescence phenotype of overexpressors was puzzling. This study highlights a relationship between autophagy, nitrogen remobilization and leaf senescence and shows how the fine-tuning of nutrient management can influence senescence onset. Conclusions The fine-tuning of autophagy is necessary to control leaf senescence.

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Fichiers liés : mcaf050.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/06/2025
• Auteurs : Jean-Baptiste CampsFlorian CafieroPhilippe Chaumet-RiffaudDamien ConceicaoUlysse GodreauÉmilie GuidiAlexandre Lionnet-RollinThéo MoinsPierre-Alexandre NistorBenedetta Salvati
• Organismes : Centre Jean Mabillon École nationale des chartes médialab (Sciences Po) Institut Hospitalo-Universitaire FOReSIGHT École nationale des chartes École nationale des chartes Université Paris Sciences et Lettres Centre Jean Mabillon Centre Jean Mabillon École nationale des chartes École nationale des chartes Centre Jean Mabillon

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Résumé : Authorship attribution for medieval texts such as those of Chrétien de Troyes poses unique challenges due to textual transmission, language variation, and limited reference corpora. In this context, it might be useful to draw as much stylistic information as possible from the texts, beyond most common features such as function words. This paper presents an ongoing project to include metrical annotation (with a focus on prosody) in the stylometric analysis of Medieval French, to enhance support vector machine (SVM)-based authorship attribution. The case at hand focuses on the attribution of the works of Chrétien de Troyes and his contemporaries.

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Fichiers liés : abstract_Chrestien_Camps_20250605.pdf

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