Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Pierre-Etienne HeudelVirginie AvrillonBenedicte MastroianniHelen BoyleSouad AssaadIsabelle Ray-CoquardJean-Philippe SpanoSylvie ChabaudClaire CropetMaurice PérolJean-Yves Blay
• Organismes : Research on Healthcare Performance
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé : Recent clinical observations suggested that COVID-19 mRNA vaccines prime innate and adaptive immunity and enhance anti-tumor immune responses, leading to improved survival of patients with cancers.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Marie DecraeckerHeloise BourienElhadji Malick ThiamJulien EdelineAlice Koudjou-SoneguengJean-Frédéric BlancGiuliana AmaddeoThomas UguenThomas DecaensNathalie Ganne-CarriéChristine SilvainMohamed BouattourGhassan RiachiManon AllaireStéphane CattanXavier AdhouteMarilyne GratienRodolphe AntyJean-Marie PeronFréderic ObertiAurore BaronAlina PascaleGeorges-Philippe PageauxSylvain ManfrediJean-Baptiste NousbaumMarie LequoyAnaïs JaillaisIsabelle Ollivier-HourmandMoana Gelu-SimeonJean-Pierre BronowickiAlexandra HeurgueAnne-Laure VillingIsabelle RosaJean-François CadranelGérard DucournauOlivier GanryCharlotte CostentinEric Nguyen-Khac
• Organismes : Centre National d'Études Spatiales [Toulouse] Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen]
• Publié dans JHEP Reports Innovation in Hepatology le 07/09/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Philippe MerleJean-Frédéric BlancKarine Le MalicotJean-Marie PeronVincent BourgeoisMohamed BouattourYann TouchefeuCarole VitelliusFaiza Khemissa AkouzAlexandra HeurguéPaul GirotEric AssenatEric Nguyen-KhacJean-Pierre BronowickiJuliette ViaudMeher Ben AbdelghaniSylvain ManfrediJulien EdelineJean-Marc PhélipKarine Le MalicotPhilippe MerleJean-Frédéric BlancJulien EdelineJean-Marie PeronVincent BourgeoisJean-Marc PhelipMohamed BouattourYann TouchefeuCarole VitelliusFaiza Khemissa AkouzAlexandra HeurguePaul GirotEric AssenatJean-Pierre BronowickiJuliette ViaudMeher Ben AbdelghaniYou-Heng LamMorgane HelyonMarion BollietSylvain ManfrediSimon LaunayRené GerolamiChristophe AgnelloAnaïs JaillaisValérie BoigeBruno HugueninPierre Guillaume PoureauMarilyne Debette-GratienBenjamin LinotManon AllaireMarie LequoyJuliette ThauryDavid TougeronLouis-Marie DourtheHélène FoisyPierre NahonCédric LecailleXavier AdhouteAnne-Claire FrinNabil Baba-HamedJérôme Martin-BabauAude MontchaudFrédéric Di Fiore
• Organismes : Service d'Hépatologie [Hôpital de la Croix-Rousse - HCL] Centre Hospitalier Universitaire de Bordeaux Epidémiologie et recherche clinique en oncologie digestive : EPICAD (CTM UMR 1231) Fédération Francophone de Cancérologie Digestive Laboratoire Hématologie - Rangueil [CHU Toulouse] Centre Hospitalier Boulogne-sur-mer Hôpital Beaujon [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP) Centre de recherche sur l'Inflammation Institut des Maladies de l'Appareil Digestif The Enteric Nervous System in gut and brain disorders [U1235] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Saint Jean de Perpignan Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Département de nutrition et d'oncologie digestive Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de Cancérologie de Strasbourg Europe Service d'Hépato-Gastro-Entérologie (CHU de Dijon) Centre Eugène Marquis Oncogenesis, Stress, Signaling Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Epidémiologie et recherche clinique en oncologie digestive : EPICAD (CTM UMR 1231) Fédération Francophone de Cancérologie Digestive Hôpital de la Croix-Rousse [CHU - HCL]
• Publié dans The Lancet Gastroenterology & Hepatology le 22/10/2020

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Résumé : Background: Patients with unresectable hepatocellular carcinoma have a poor prognosis and treatments with long-term benefits are needed. Anti-PD-L1 or anti-PD-1 plus anti-VEGF or anti-CTLA-4 double combinations are validated, first-line, systemic immunotherapies. We report the preplanned phase 2 results of the phase 2-3 PRODIGE 81-FFCD 2101-TRIPLET-HCC trial investigating the survival outcomes and safety profile of a triple combination of atezolizumab, bevacizumab, and ipilimumab in a first-line setting. Methods: This randomised, open-label, phase 2-3 trial enrolled patients aged 18 years or older with unresectable hepatocellular carcinoma without previous systemic therapy at 36 hospitals in France. Patients had at least one measurable untreated lesion per Response Evaluation Criteria in Solid Tumours version 1.1 (RECIST v1.1), Child-Pugh class A disease, and an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Patients were randomly assigned (1:1) to receive intravenous treatment every 3 weeks for up to 2 years with atezolizumab 1200 mg plus bevacizumab 15 mg/kg (plus ipilimumab 1 mg/kg for up to four doses), or atezolizumab plus bevacizumab alone. Subsequent follow-up was for a further 2 years. Randomisation was done centrally by the study funder, via an electronic case report form, using the minimisation method, and stratified by centre, ECOG performance status, macrovascular invasion or extrahepatic spread (or both), and baseline α-fetoprotein. We report the non-comparative phase 2 results with a primary endpoint of objective response (complete or partial) within the first 24 weeks of treatment, assessed per investigator by RECIST v1.1, in patients who received at least the first dose of study medication (modified intention-to-treat population); 35 patients in the experimental group needed to have had an objective response at week 24 for the trial to progress to phase 3. Missing data were not replaced. The trial is registered with ClinicalTrials.gov (NCT05665348) and is complete. Findings: Between March 9, 2023, and Sept 20, 2024, 229 patients were randomly assigned to treatment and 226 received at least one dose of study medication; 113 patients received atezolizumab plus bevacizumab plus ipilimumab and 113 received atezolizumab plus bevacizumab. 206 (91%) patients were male and 20 (9%) were female. At 24 weeks, 34 (30% [80% CI 24-36]) patients in the atezolizumab plus bevacizumab plus ipilimumab group had an objective response as had 31 (27% [22-34]) patients in the atezolizumab plus bevacizumab group. The trial was therefore stopped and did not progress to phase 3. The most common (>2% of patients) investigator-assessed treatment-related, grade 3-4 adverse events in the atezolizumab plus bevacizumab plus ipilimumab group were colitis (four [4%] patients), confusional syndrome (three [3%]), arterial hypertension (11 [10%]), and asthenia (six [5%]); the most common in the atezolizumab plus bevacizumab group were acute renal failure (three [3%] patients), proteinuria (four [4%]), gastrointestinal bleeding (six [5%]), arterial hypertension (13 [12%]), increased aspartate aminotransferase (three [3%]), increased alanine aminotransferase (three [3%]), and increased lipasaemia (three [3%]). Serious adverse events were reported in 55 (49%) patients in the atezolizumab plus bevacizumab plus ipilimumab group and in 48 (42%) patients in the atezolizumab plus bevacizumab group. Treatment-related adverse events resulting in death occurred in six (5%) patients in the atezolizumab plus bevacizumab plus ipilimumab group and none in the atezolizumab plus bevacizumab group. Interpretation: The addition of ipilimumab to atezolizumab plus bevacizumab did not show any benefit in patients with previously untreated, unresectable hepatocellular carcinoma. These results do not support the addition of low-dose (1 mg/kg) ipilimumab to atezolizumab plus bevacizumab as a first-line treatment in this setting.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Rita BitarPhilippe BlumsteinNicolas SoetartPierre CordierMaria Dolores SanchezBienvenue RazafimandimbyFaraj FajlounJean-Philippe BoucharaJacques GuillotEmmanuel Bensignor
• Organismes : SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique
• Publié dans Journal of Medical Mycology = Journal de Mycologie Médicale le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Aurelien AmiotAxel AhresCarmen StefanescuAntoine MeyerMaria NachuryStéphane NanceyNicolas RichardMatthieu AllezRomain AltweggDavid LaharieMélanie SerreroDenis FranchimontMarianne HupéMathurin FumeryLucine VuittonStéphane NahonCyrielle GillettaCléa RouillonAlexandre NuzzoCatherine Le BerreBénédicte CaronAnthony BuissonMorgane AmilMaëva CharkaouiGuillaume CadiotLudovic CailloMarion SimonCatherine ReenaersXavier HébuterneLaurianne PlastarasCalina AtanasiuSandy KwiatekMathieu UzzanAnne-Laure PelletierAlban BenezechMathias VidonFelix GoutorbeSophie GeylChristophe CellierCéline MontuclardDriffa MoussataPhilippe Seksik
• Organismes : Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Université Paris-Saclay Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Université Paris-Saclay Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] Research Institute of the McGill University Health Centre Institut de Recherche Saint Louis CHU Montpellier = Montpellier University Hospital Hôpital Haut-Lévêque [CHU Bordeaux] Hôpital Nord [CHU - APHM] Aix Marseille Université Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Groupe Hospitalier Intercommunal Le Raincy-Montfermeil Service Gastroentérologie, hépatologie nutrition, diabétologie et maladies héréditaires du métabolisme pédiatrique [CHU Toulouse] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital Beaujon [AP-HP] Laboratoire de Recherche Vasculaire Translationnelle The Enteric Nervous System in gut and brain disorders [U1235] Nutrition-Génétique et Exposition aux Risques Environnementaux Centre Hospitalier Régional Universitaire de Nancy Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Service d'Hépato-Gastro-Entérologie (CHU de Dijon) Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Nîmes Institut Mutualiste de Montsouris Centre Hospitalier Universitaire de Liège Centre Hospitalier Universitaire de Nice CH Colmar Centre hospitalier Saint-Joseph [Paris] CHU Sud Saint Pierre [Ile de la Réunion] Hôpital Henri Mondor CIC - CHU Bichat Centre Hospitalier Henri Duffaut [Avignon] Centre Hospitalier Intercommunal de Créteil Centre Hospitalier de la Côte Basque CHU Limoges Hôpital Européen Georges Pompidou [APHP] Centre hospitalier de Valence Centre Hospitalier Régional Universitaire de Tours Gut,Liver & Microbiome Research FHU
• Publié dans Clinics and Research in Hepatology and Gastroenterology le 26/10/2020

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Résumé : Background and aims Bowel urgency is one of the most distressing symptoms experienced by patients with inflammatory bowel disease (IBD). The relationship between bowel urgency and multidimensional IBD-related disability has not been well characterised. Patients and methods We conducted a multicentre cross‑sectional study including adult patients with Crohn’s disease (CD) and ulcerative colitis (UC). Patients completed self-administered questionnaires evaluating bowel urgency and IBD-related disability using the IBD-Disk questionnaire. Severe bowel urgency was defined as a IBD-disk bowel urgency subscore ≥6. Results A total of 2,514 patients (1,715 with CD) were included. Severe bowel urgency was observed in 17.1% of patients with UC and in 20.4% of patients with CD, compared to 3.6% and 7.6%, respectively, in those in clinical remission according to PRO-2 criteria. In multivariate analysis in patients with UC, factors associated with severe bowel urgency were general well-being subscore ≥2 and abdominal pain subscore ≥2 while treatment with advanced therapy, clinical remission according to PRO-2, fatigue subscore <5, work productivity subscore <3 and sexual life subscore <2 were negatively associated. In patients with CD, factors were rectal bleeding subscore ≥2, abdominal pain subscore ≥2 and history of intestinal resection while clinical remission, fatigue subscore <5, work productivity subscore <3 and sexual life subscore <2 were negatively associated. Conclusion Severe bowel urgency is frequent in both patients with CD and UC beyond IBD activity and is strongly associated with various dimensions of IBD-related disability. These findings emphasise the importance of systematically assessing urgency in routine clinical practice.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Jean-Pascal FournierAurélie GaultierValéry-Pierre RichePhilippe TessierCédric RatJérôme Nguyen-Soenen
• Organismes : Préventions, Organisations et Parcours en Soins primaires Département de médecine générale [Nantes Université - UFR de Médecine et des Techniques Médicales] Département de médecine générale [Nantes Université - UFR de Médecine et des Techniques Médicales] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université methodS in Patients-centered outcomes and HEalth ResEarch Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Préventions, Organisations et Parcours en Soins primaires Département de médecine générale [Nantes Université - UFR de Médecine et des Techniques Médicales] methodS in Patients-centered outcomes and HEalth ResEarch Département de médecine générale [Nantes Université - UFR de Médecine et des Techniques Médicales] Préventions, Organisations et Parcours en Soins primaires
• Publié dans JAMA Internal Medicine le 31/10/2020

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Résumé : Importance Inappropriate use of proton pump inhibitors (PPIs) is associated with severe adverse drug reactions and may significantly increase health care costs. Deprescribing should be considered when inappropriate use is identified. Objective To evaluate the effectiveness of a patient- and general practitioner (GP)–facing intervention in reducing potentially inappropriate PPI use in primary care. Design, Setting, and Participants This pragmatic, cluster-randomized, open-label, clinical trial was conducted between November 12, 2020, and November 11, 2021. Participants were adults aged 18 years or older with at least 1 year of PPI use in GP practices in 2 regions of western France, and their GPs were included. Data were analyzed from January to July 2025. Interventions GP practices were randomized to 3 groups in a 1:1:1 ratio as follows: (1) a patient- and GP-facing deprescribing intervention combining a patient education brochure on PPI deprescribing posted directly to patients with a letter outlining a PPI deprescribing algorithm sent to their GPs; (2) a GP-facing intervention, in which only the GP received the letter and algorithm; or (3) usual care. Main outcomes and measures The primary outcome was PPI dose reduction, defined as a 50% or more reduction in annual PPI use, measured in defined daily doses (DDDs) and proxied by reimbursement claims. Secondary measures included Gastroesophageal Reflux Disease Impact Scale (GIS) scores, assessed in a 10% sample. Results A total of 1498 GPs and 34 409 patients were included from 683 primary care practices. The mean (SD) patient age was 68.6 (14.0) years, and 19 507 (56.7%) were female. Mean (SD) baseline annual PPI use was 413.7 (113.9) DDDs. PPI dose reduction was higher in the patient- and GP-facing intervention group compared with the usual care groups (1710 of 11 442 patients [14.9%] vs 825 of 11 732 [7.0%]; adjusted absolute difference, 6.9%; 95% CI, 5.7%-8.3%; P &lt; .001) and with the GP-facing intervention (1710 of 11 442 patients [14.9%] vs 862 of 11 235 [7.7%]; adjusted absolute difference, 6.7%; 95% CI, 5.4%-8.2%, P &lt; .001). GIS scores did not significantly differ between groups. Conclusions and relevance This randomized clinical trial found that the patient- and GP-facing intervention was effective in reducing potentially inappropriate PPI use without any meaningful impact on long-term gastroesophageal reflux disease activity. Trial Registration ClinicalTrials.gov Identifier: NCT04255823

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Fichiers liés : Fournier - Manuscript JAMA Int Med HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Elias KaramCharles de PonthaudAlexandra NassarClément PastierAntoine CastelAlessandro MazzottaFrancois SoucheR RhaiemElsa JollyJonathan GarnierRégis FaraManon ViennetFabio GiannoneJohan GagnièreFrédéric BorieMehdi BoubaddiLilian SchwarzClément-Louis GaubertFrançois PattouNicolas MeurisseJean LubranoAlain ValverdeGabriella PittauAlexandre DoussotEmilia RagotJean-Marc BigourdanAmandine PintoJulie VéziantAlexis LaurentMehdi El AmraniEdouard GirardJeanne DembinskiPetru BucurPietro AddeoAna CharlaixEmilie LermitePaye FrançoisBenjamin DarnisJérôme DanionDavid BirnbaumLionel JouffretRenato Micelli LupinacciLaurent BrunaudMartin BrunelJohanna ZemourRodolfo VeceTullio PiardiPatrice DavidAlban Le BianAntonio CunhaHéléne CortéSamir MahfoufReza KianmaneshFabrice MuscariLaurent SulpiceAlain SauvanetDavid FuksOlivier Saint-MarcSafi DokmakSébastien GaujouxThibaud BertrandJulien de MartinoGéraldine RousseauOlivier ScattonAngelica NepiChloé DavidUgo MarcheseGaanan NaveendranStylianos TzedakisAmbroise Duval-BinetSamuel Santos Barreira RodriguesRaffaele de RosaOlivier SoubraneMorgane BarraEcoline TribillonJean-Michel FabreThomas BardolNicolas CarrèreCharlotte MaulatAnaïs PalenJacques EwaldOlivier TurriniJulie LeclercAhmet AyavJean-Baptiste LequeuCyrille KuperasOlivier FacyPatrick PessauxArne KockMarie NoiraultEmmanuel BucAdnan AboukassemMartin BertrandArthur MarichezChristophe LaurentLaurence ChicheEloïse PapetJean PinsonMatthieu MongeNicolas RegenetRobert CaiazzoJérôme MarcelleMorgane VandermeulenArnaud de RooverCoralie LacroixThierry BensignorNicolas GoasguenDaniel PietraszCaterina AccardoCélia TurcoBruno HeydMehdi KarouiJean VixAmine GouaderRégis GailletonOktavian DaskaliukGuillaume PiessenEloïse BonninRim CherifGiorgio BianchiPhilippe ZerbibAlain SaudemontStéphanie TruantJulio AbbaMircea ChiricaPauline LéourierJean-Marc RégimbeauEphrem SalaméPhilippe BachelierMarie BougardJulie DeyratCindy VuillermetHortense BoullenoisMarie DavidJean-Pierre FaureVincent MoutardierJean-Luc ScesaMorgane BouquotAbdallah KhayatHatim LazaarBaudoin ThébaultBetrand Le RoyJérôme DeheppePierre SauvanetJérémie ThereauxAudrey MayetBogdan BadicAnne de CarbonnièreJean GugenheimChristophe TresalletAmine ChamakhiLaura ChreimMarie André
• Organismes : Centre Hospitalier Régional Universitaire de Tours Membrane Signalling and Inflammation in reperfusion Injuries CHU Pitié-Salpêtrière [AP-HP] Health data-and model-driven approaches for Knowledge Acquisition Hôpital Cochin [AP-HP] Institut Cochin Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Département de Chirurgie Digestive B et Transplantation [Hôpital Saint-Eloi - CHU Montpellier] Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Toulouse Centre de Recherche en Cancérologie de Marseille Institut Paoli-Calmettes Hôpital Européen [Fondation Ambroise Paré - Marseille] Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon) L'Institut hospitalo-universitaire de Strasbourg Hôpitaux Universitaires de Strasbourg Service Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand] Université Clermont Auvergne Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Hôpital Universitaire Carémeau [Nîmes] Université de Bordeaux Service de Chirurgie Digestive [CHU Rouen] Medical Training Center [CHU Rouen] Cancer and Brain Genomics Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Liège Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Chirurgie digestive [CHU Amiens] Chirurgie digestive [CHU Amiens] Simplification des soins chez les patients complexes - UR UPJV 7518
• Publié dans HPB le 26/10/2020

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Résumé : Background: Pancreatic resection (PR) may require portal/superior mesenteric vein resection (VR). Outcomes of minimally invasive PR (MIPR) with VR are poorly studied. Methods: Multicentric retrospective cohort of MI pancreatoduodenectomy (MIPD) and left pancreatectomy (MILP) with or without VR between 2010 and 2021. Propensity score matching analysis stratified on age, sex, BMI, pancreas texture, tumor type, ASA score, conversion and surgical approach was performed. Results: After matching, 234 MIPD were included, 78 (33.3%) with and 156 (66.7%) without VR. VR had greater blood loss (400 vs 300 mL; p = 0.033) and operative time (471 vs 430 min; p = 0.012). VR had 10.3% mortality compared to 4.5% (p = 0.097), similar severe morbidity (30.8% vs 37.8%: p = 0.313) and R0 resection rate (84.9% vs 90.8%: p = 0.252). After matching, 275 MILP, 25 (9%) with and 250 (91%) without VR were compared. VR had greater blood loss (350 vs 150mL; p = 0.019) and operative time (300 vs 240 min; p = 0.005). VR had 8% mortality versus 2% (p = 0.126), 19.2% severe morbidity versus 8% (p = 0.274) and lower R0 resection rate (58.3% vs 94.9%; p <0.001). Conclusion: MIPR with VR has non-significant increased postoperative mortality, lower R0 resection rate and therefore cannot be considered as a standard of care.

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• Type de publi. : Article dans une revue
• Date de publi. : 29/05/2026
• Auteurs : Yves LevyChristiane MoogAurélie WiedemannOdile LaunayFabio CandottiLucile HardelMélany DurandBoris P. HejblumVéronique RieuxAlpha DialloChristine LacabaratzSylvain CardinaudSandra ZurawskiGerard ZurawskiGeorgia D TomarasSong DingMireille CentlivreRodolphe ThiébautGiuseppe PantaleoJean-Daniel LelièvreLaura RichertTugba AgyarMotolete Alaba TanahFrédéric BatteuxRaida Ben RayanaLaurène BorieMagali BouvierKahina CherefVanessa ChristinetThomas DecovilleMathilde DesvalléesHarouna DiomberaMathilde FavreauCraig FenwickEmile FoucatCamille GilbertTapia GonzaloSophie GrabarPascal GrangeCorinne GuerinLaurent HanotHakim HociniEmma JousseaumePhilippe KiehlCorinne KriefMarie LachatreGéraldine LaumondLéa LevoyerLi-Yun LiLiem Binh LuongHanane MehawejNoémie MercierLaura MolinariStéphane PaulBéatrice ParfaitHélène PollardSylvie SchmidtIsabelle SommerLaure SurgersFrancesco TommasiniMuriel Verlinde-CarvalhoJean-Paul ViardAline VoideyLinda WittkopMarta Zatta
• Organismes : Vaccine Research Institute [Créteil, France] Institut Mondor de Recherche Biomédicale Service d'immunologie clinique [Créteil] Vaccine Research Institute [Créteil, France] Immuno-Rhumatologie Moléculaire Vaccine Research Institute [Créteil, France] Institut Mondor de Recherche Biomédicale CIC Cochin Pasteur Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Vaccine Research Institute [Créteil, France] Statistics In System biology and Translational Medicine Bordeaux population health Statistics In System biology and Translational Medicine Vaccine Research Institute [Créteil, France] Bordeaux population health Vaccine Research Institute [Créteil, France] Agence Nationale de la Recherche Institut Mondor de Recherche Biomédicale Vaccine Research Institute [Créteil, France] Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Vaccine Research Institute [Créteil, France] Baylor Institute for Immunology Research Institut Mondor de Recherche Biomédicale Vaccine Research Institute [Créteil, France] Baylor Institute for Immunology Research Duke University Medical Center EuroVacc Foundation Institut Mondor de Recherche Biomédicale Vaccine Research Institute [Créteil, France] Statistics In System biology and Translational Medicine Vaccine Research Institute [Créteil, France] Institut Mondor de Recherche Biomédicale Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Université de Lausanne = University of Lausanne Vaccine Research Institute [Créteil, France] Institut Mondor de Recherche Biomédicale Statistics In System biology and Translational Medicine Bordeaux population health CIC Bordeaux CHU de Bordeaux Pellegrin [Bordeaux] Université de Bordeaux Hôpital Hôtel-Dieu [Paris] Université Paris Cité Servie d'immunologie biologique [CHU Cochin] Institut Cochin Université Paris-Est Créteil Val-de-Marne - Paris 12 Hôpital Henri Mondor CHU Henri Mondor [Créteil] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine Association de Soutien aux Centres de Recherches, d'Enseignements et de Soins Immuno-Rhumatologie Moléculaire Fédération de Médecine Translationnelle de Strasbourg Vaccine Research Institute [Créteil, France] Institut Mondor de Recherche Biomédicale Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Université de Lausanne = University of Lausanne Institut Mondor de Recherche Biomédicale Methods and Applied Research for Trial [UNIV Bordeaux] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Laboratoire Bordelais de Recherche en Informatique Hôpital Cochin [AP-HP] Centre International de Recherche en Infectiologie Université Jean Monnet - Saint-Étienne Physiopathologie et biothérapies des infections muqueuses [CIRI] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] Autophagie infection et immunité - Autophagy Infection Immunity [CIRI] Transgene SA Service d'immunologie - Suivi des biothérapies [CHU Saint-Etienne] Statistics In System biology and Translational Medicine
• Publié dans Scientific Reports le 26/10/2020

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Résumé : The ANRS VRI06 trial investigated CD40.HIVRI.Env, an Antibody Mediated Vaccine composed by a CD40 monoclonal antibody fused with gp140 Env, designed to target antigen to dendritic cells. Initial results in 72 HIV-uninfected volunteers showed that administration of 0.3-3.0 mg of CD40.HIVRI.Env, given alone or with DNA-HIV-PT123, was safe and immunogenic up to 48 weeks. After week 48 in the trial, 45 volunteers were randomized to receive a late boost (LB) of 0.3 mg CD40.HIVRI.Env, either with or without adjuvant, to assess continued safety and immunogenicity at 2 and 24 weeks post-LB. The median LB interval from VRI06 baseline was 80 and 79 weeks in unadjuvanted (n=23) and adjuvanted (n=22) groups, respectively. Env-specific IgG and functional CD4+ T-cells persisted at the time of the LB, a median of 55 weeks after the last injection at W24. The LB was well tolerated and markedly boosted immune responses. In particular: i) IgG response rates against gp140 and 9 gp120 antigens reached 100% (vaccine-matched) and 82-100% (heterologous) by 24 weeks post-LB; ii) response rates to gp70 V1V2 antigens increased substantially (e.g., from 0-5% to 5-35%) against autologous 96ZM651 and heterologous V1V2 antigens; iii) neutralizing titers against Tier 1 MW965.26 rose from 14-22% to 35-59%; iv) the frequency of polyfunctional Env-specific CD4+ T-cells increased and persisted 24 weeks post-LB. No marked differences were observed between adjuvanted and unadjuvanted LB groups. CD40.HIVRI.Env vaccination is safe and induced broad, potent and long-lasting anti-HIV immune responses recalled by a single late boost, even without adjuvant. Trial registration: Clinical Trials.gov NCT04842682 ||https://www.clinicaltrials.gov/ (2021-04-13)

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Fichiers liés : s41598-026-52363-4_reference.pdf

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 26/05/2026
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamLisa BenatoThomas BergauerMarko DragicevicPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanJochen SchieckRobert SchöfbeckMaryam ShooshtariMangesh SonawaneNiels van den BosscheWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenDonya AhmadiJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtChirayu GuptaFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoSaranya NandakumarStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinFranco Caviglia RomanBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerEliott DucarmeHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehAndrea MalaraMuhammad Aamir ShahzadArchana SharmaLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangAmber CauwelsMaarten de CoenDidar DoburCristina GiordanoGul GokbulutKaram KasparDavid KavtaradzeDavid MarckxKirill SkovpenAdina Maria TomaruJan van der LindenJules VandenbroeckHenriette Aarup PetersenSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereFrancisco Gameiro CasalinhoAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselDiego Matos FigueiredoThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnKatherine Maslova Gioseffi DefanteKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesLuigi CalligarisFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteMeena MeenaShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanJinjing GuZhen HuZhengchen LiangJinfeng LiuXining WangYuxiao WangHeng YangShunliang ZhangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian 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Résumé : Possible anomalous couplings of the Higgs boson to vector bosons and fermions are studied using Higgs boson candidates decaying to a pair of photons. The study is based on proton-proton collision data at $\sqrt{s}$ = 13 TeV collected by the CMS experiment, corresponding to an integrated luminosity of 138 fb$^{-1}$. Events with Higgs boson candidates produced via gluon fusion, electroweak vector boson fusion and in association with a vector boson, are categorized using matrix element techniques and multivariate discriminants. The $CP$ properties of the Higgs boson couplings to gluons through loops of heavy particles, as well as the tensor structure of its interactions with two electroweak bosons, are investigated. The results are interpreted in terms of the fractional contributions of anomalous Higgs boson couplings to the total production cross section of each process and are found to be consistent with the standard model expectations.

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