Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 24/11/2025
• Auteurs : Elsa LeitãoAmandine SantiniBenjamin CognéMyriam EssidMaria AthanasiadouChristy LaflammePierre MarijonVirginie BernardNicolas ChatronGiulia BarciaBoris KerenCyril MignotPerrine CharlesThomas BesnardJean-Madeleine de Sainte AgatheEdith FuerteSoham SenguptaMathieu MilhFrancis RamondTalia AllanIsabelle AnCamila AraujoStephanie ArpinChristina Austin-TseStéphane AuvinSarah BaerNadia Bahi-BuissonMads BakMagalie BarthStéphanie BaulacNathalie Bednark WeirauchMatthias BegemannMark BennettUriel BensabathStéphane BézieauRakia BhouriMargaux BiehlerTrine Bjørg HammerJulie BogoinEmilie BonannoSimon BoussionNuria BramswigCéline BrisAdelaide Brosseau-BeauvirAnge-Line BruelJulien BurattiPascal ChambonNicole ChemalyBertrand ChesneauEstelle ColinMaxime ColmardSolène ConradThomas CourtinLouis DangAnne de Saint MartinCaroline de Vanssay de Blavous LegendreAnne‐sophie Denommé‐pichonStephanie DitroiaMartine Doco-FenzyChristèle DubourgCharlotte DubucsStéphanie DucreuxLouis DufourRomain DuquetBenjamin DurandSalima El ChehadehMiriam ElbrachtLaurence FaivreMarie FaoucherAnne FaudetSylvie ForlaniMélanie FradinPauline GaignardBenjamin GanneAurore GardeJustine GéraudDeepak GillAlice GoldenbergDavid GrabliCoraline GriselSophie GuedenPaul GueguenAnne-Marie GuerrotAgnès GuichetNina HärtingMartin Georg HäuslerSolveig HeideBénédicte HéronDelphine HéronMathilde HeulinClara HoudayerBertrand IsidorAurélia JacquetteLouis JanuelNolwenn Jean-MarçaisKevin JousselinFrank KaiserSabine KayaChontelle KingMarina KonyukhFlorian KraftJeremias KrauseRémi KirstetterAlma KuechlerIngo KurthAudrey LabalmeJean-Serene LaloyVincent LaugelFloriane Le BricquirAnne Sophie LebreMarine LebrunEric LeguernJonathan LevyNico LiefferingStanislas LyonnetKevin LüthySian MacdonaldLamisse Mansour-HendiliJulien MaravalCarolin MattauschOlfa MessaoudGodelieve MorelJérémie MortreuxArnold MunnichRima NabboutSophie NambotVincent NavarroAshana NealeLaetitia NguyenMathilde NizonFrédérique NowakMelanie O’learySylvie OdentNaomi Meave OjedaValerie OlinKatrin ÕunapLynn PaisRobin PaluchEleni PanagiotakakiOlivier PatatLaurence Perrin-SabourinFlorence PetitChristophe PhilippeAmélie PitonMarc PlanesCéline PoirsierAntoine PouzetClément ProuteauSylvia Quéméner-RedonMathilde RenaudAnne-Claire RichardMarlène RioClotilde RivierFlorence Robin-RenaldoPaul RollierM. RossiAgathe RoubertieMailys RupinPascale Saugier-VeberRussell SanetoElisabeth SarrazinElise SchaeferCaroline Schluth-BolardAmy SchneiderIsabell SchumannVladimir SeplyarskiyThomas SmolShamil SunyaevBrian Sperelakis-BeedhamSarah StentonFriedrich StockMylene TharreauDeniz TorunJoseph ToulouseHarshini ThiyagarajahStéphanie ValenceSophie ValleixLaurent VillardDorothée VilleNathalie VilleneuveAntonio VitobelloAurélie WaernessyckleYvonne WeberDagmar WieczorekTom WitkowskiManya YadavilliTony YammineKhaoula Zaafrane-KhachnaouiMaha ZakiAlban ZieglerAlban LermineGaël NicolasJoseph GleesonLynette SadleirMichael HildebrandIngrid SchefferNicola WhiffinAnne O’donnell-LuriaHeather MeffordPierre BlancJulien ThevenonCamille CharbonnierClément CharentonChristel DepienneGaëtan LescaCaroline Nava
• Organismes : Institut du Cerveau = Paris Brain Institute

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Résumé : Abstract Variants in spliceosomal small nuclear RNA (snRNA) genes RNU4-2 (ReNU syndrome), RNU5B-1 , and RNU2-2 have recently been linked to dominant neurodevelopmental disorders (NDDs), revealing a major, previously overlooked role for noncoding snRNAs in human disease. Here, we systematically analysed 200 potentially functional snRNA genes in a French cohort comprising 26,911 individuals with rare disorders and through international collaborations. We identify de novo and biallelic variants in RNU2-2 associated with both dominant and recessive NDDs in 126 individuals from 108 unrelated families. Recessive RNU2-2 NDD is at least twice as frequent as the dominant NDD caused by n.4G>A and n.35A>G, and often arises from a de novo variant in trans with an inherited allele, reflecting the high mutability of snRNA genes. Dominant and recessive RNU2-2 -NDDs share overlapping clinical features with frequent epilepsy. Blood transcriptomics and DNA methylation analyses revealed subtle, variant-specific effects on splicing and episignatures. Our findings support a gradient-of-impact model and a continuum between dominant and recessive inheritance, establishing RNU2-2 variants as a frequent cause of NDDs, nearly as prevalent as ReNU syndrome.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 24/11/2025
• Auteurs : Julien AndreaniJean-Pierre BaudoinLéana LaumierLucile PinaultAlice ChanteloupPhilippe ColsonBernard La Scola
• Organismes : Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Assistance Publique - Hôpitaux de Marseille Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans Virology Journal le 01/11/2020

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Résumé :

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Fichiers liés : 12985_2025_Article_2997.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/11/2025
• Auteurs : Florent LheureuxMaxime JollivetJuliette ChironSarah PouletAlicia FournierGilles CapellierLaëtitia Bodet-ContentinAntoine HéraultJoffrey HamamPascal BeuretPierre-Alexandre LamizetMathieu SchoefflerBérengère VivetChristophe GuittonGaël PitonJustine PerrotKhaldoun KuteifanCéline GuichonHodane YonisOlivier BarbotCarole SchwebelPierre-Yves OlivierEnora AtchadeAlexis DürrFrédérique SchortgenClaire BourelDiane FriedmanCaroline Hauw-BerlemontLaura FedericiAnne-Sophie MullerKada KloucheCharles DamoiselSabine ValeraGhada SbouiCathy LemaitreAntonin MichaudAlexandra BeurtonEmeline ButtazzoniCamille AïtoutBérengère AraujoLaurence GoncalvesSylvie CanonAnne CouvillersAnne-Laure PoujolJuliette TouletBélaïd BouhemadFrançois AptelCyril GoulenokA. LaurentMaxime GranierClémentine HoareauIsabelle BourgoinFabienne TamionEmilie Saint LegerDéborah HironHubert GrandAude LondeixCéline MarconnetFlorent MontiniLaetitia VolleKarine HerbertCorinne MouriouxLaurence GroshenryClaire ChagnatMelissa CrotetJuliette MeunierSéverine GuillarmeHadrien WiniszewskiSarah NoirLaure ClouetFrancis AugierIsabelle ZamofingJean-Cyril van HammeMarie-Anne TisserandJean-Christophe RichardMathieu RulliereEmmanuelle RouveFlorence ThevenotAurélie MaillachEve MerzoukiCarole HaubertinPhilippe MontraversAurélie Gouel-CheronMathilde DijouxMartial ThyraultLéopoldine LegrainCécilia Tabra OsorioEmilie AebischerRaphaël FavoryEvelyne EgretDjillali AnnaneAnne RobinSégolène JourdierSarah FerteLaurent SerpinCécile CapelliAlice PreaultDelphine DaubinCorinne PelleClaudine GniadekStéphanie GaliaJean-Marie ForelSabine JanowskiJerôme VandensteenJulien PoissyVincent CastelainSylvie L’hotellierJeanne SovantMuriel FartoukhLaurence KrzyzaniakPierre-Grégoire GuinotChristelle JaultArmand Mekontso DessapMaryline CouetteSébastien PreauSaadalla NseirSandrine Ndinga MondzeMercedes Jourdain
• Organismes : Laboratoire de Psychologie - UFC (UR 3188) Laboratoire de Psychologie - UFC (UR 3188) CY Cergy Paris Université, Laboratoire BONHEURS Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras Laboratoire de Psychologie - UFC (UR 3188) Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] Centre hospitalier Notre-Dame de la Miséricorde [Ajaccio] methodS in Patients-centered outcomes and HEalth ResEarch Centre d’Investigation Clinique [Tours] CIC 1415 Réseau CRICS-TRIGGERSEP [Clinical Research in Intensive Care and Sepsis - TRIal Group for Global Evaluation and Research in SEPsis – Labellisé F-CRIN (French Clinical Research Infrastructure Network)] Centre Hospitalier Régional Universitaire de Tours Hôpital Charles Nicolle [Rouen] Department of Intensive Care Medicine, Hospital of Libourne, Libourne Centre Hospitalier de Roanne Centre hospitalier d'Arles Centre hospitalier de Montélimar [Hôpital de Montélimar] = Montélimar Hospital Groupe Hospitalier de La Haute-Saône Centre Hospitalier Le Mans (CH Le Mans) Service d'anesthésie et soins intensifs [CHRU Besançon] Service d'anesthésie - réanimation chirurgicale [CHU de Dijon] Groupe hospitalier de la région de Mulhouse et Sud-Alsace Hospices Civils de Lyon Hôpital de la Croix-Rousse [CHU - HCL] Hospices Civils de Lyon Centre Hospitalier Saint Jean de Perpignan Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire d'Angers AP-HP - Hôpital Bichat - Claude Bernard [Paris] Groupe Hospitalier Nord Essonne [Longjumeau] Centre Hospitalier Intercommunal de Créteil Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Raymond Poincaré [AP-HP] Hôpital Européen Georges Pompidou [APHP] Centre hospitalier Notre-Dame de la Miséricorde [Ajaccio] Centre Hospitalier de Bastia Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] AP-HP - Hôpital Antoine Béclère [Clamart] Assistance publique des Hôpitaux de Marseille Centre Hospitalier de Béthune Centre Hospitalier Régional Universitaire de Lille Centre Hospitalier Universitaire [Strasbourg] Neurophysiologie Respiratoire Expérimentale et Clinique Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Universitaire de Toulouse Hôpital Henri Mondor Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Régional Universitaire de Lille Centre Hospitalier Régional Universitaire de Lille CHU Pitié-Salpêtrière [AP-HP] Equipe VCR, Ecole de Psychologues Praticiens Centre Hospitalier Régional Universitaire de Lille CHU Dijon Centre Hospitalier Jura Sud [Lons-le-Saunier] Hôpital Privé Jacques Cartier [Massy] Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand TRANSCOV-study group TRANSCOV-study group Centre Hospitalier Henri Duffaut (Avignon) Popular interaction with 3d content Centre Hospitalier Régional Universitaire de Besançon
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Assessing sources of job stress in intensive care units is a critical issue for preventing many occupational health and care-related issues, such as burnout, voluntary turnover and decrease in quality and safety of care. Accordingly, this French nation-wide multicentre study aims to provide supplementary evidence regarding the validity of a recent tool: the Perceived Stressors in Intensive Care Units (PS-ICU) scale. More precisely, this study has three main objectives: to 1) confirm the metrological properties of the PS-ICU scale on a large sample of professionals; 2) test its measurement invariance between nurses, physicians and residents (initial population targeted by the scale); 3) examine whether the scale would also be suited for use with nursing auxiliaries. In addition, depending on the results (which may suggest the removal of several items), this study offers the possibility to shorten the scale to facilitate its use. Method and results 2241 ICU professionals (1135 nurses, 308 physicians, 179 residents, and 619 nursing auxiliaries; overall participation rate of 58.10%) from 42 ICUs in France, voluntarily completed an online questionnaire collecting socio-demographic data and perceived job stressors (PS-ICU). Exploratory structural equation modelling (ESEM), unidimensional reliability (McDonald’s Omega) and item response theory (IRT) analyses overall confirmed the metrological properties of the scale, while several items were removed and the sixth factor (“lack of support and resources from the organisation”) measured by the scale was revised. Results regarding measurement invariance show that the PS-ICU scale can be used to compare occupational groups, including nursing auxiliaries. Finally, all analyses resulted in a reduction of the scale to a 26-item version. Conclusions The PS-ICU scale, which measures generic and ICU-specific job stress factors, is a valid and reliable scale that can be used to collect data from nurses, physicians and residents, as well as from nursing auxiliaries. With 26 items, it can be used by researchers and managers in ICUs to assess the extent and type of stress factors perceived by healthcare professionals.

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Fichiers liés : 2025 Lheureux et al., Further analysis.pdf

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 20/11/2025
• Auteurs : Roel AaijAhmed Sameh Wagih AbdelmottelebCarlos Abellan BetetaFernando Jesus AbudinénThomas AckernleyAyomide Matthew AdefisoyeBernardo AdevaMarco AdinolfiPatrik Harri AdlarsonChristina AgapopoulouChristine Angela AidalaZiad AjaltouniSimon AkarKazuyoshi AkibaPietro AlbicoccoJohannes AlbrechtRamunas AleksiejunasFederico AlessioPaula Alvarez CartelleRenaud AmalricSandra AmatoJake Lewis AmeyYasmine AmhisLiupan AnLucio AnderliniMartin AnderssonPasquale AndreolaMirco AndreottiSergio Andres EstradaAlessia AnelliDong AoCarolina ArataFlavio ArchilliZaratsyan AregMatteo ArgentonSergio Arguedas CuendisLisa ArnoneAlexander ArtamonovMarina ArtusoElie AslanidesRita Ataíde da SilvaMichele AtzeniBenjamin AudurierJuliette AuthierDavid BacherIrene Bachiller PereaSebastian BachmannMarie BachmayerJohn BackPablo Baladron RodriguezVladislav BalaguraAnna BalboniWander BaldiniZachary BaldwinLuca BalzaniHaoran BaoJuan Baptista de Souza LeiteCarlos Javier Barbero PretelMatteo BarbettiIvanildo Rui BarbosaRoger BarlowMikhail BarnyakovSergey BarsukWilliam BarterJustin BartzSaliha BashirBaasansuren BatsukhPiera BattistaAurelio BayAnja BeckMaik BeckerFranco BedeschiIgnacio BediagaNoah Albin BehlingSamuel BelinAlberto BellavistaKonstantin BelousIlia BelovIvan BelyaevGaya BenaneGiovanni BencivenniEli Ben-HaimAlexander BerezhnoyRoland BernetSergi Bernet AndresAlessandro BertolinFederico BettiJosh BexOleg BezshyykoSenjuti BhattacharyaJihyun BhomMartin Stefan BiekerNicolo Vladi BiesuzAlice BiolchiniMatthew BirchFionn Caitlin Ros BishopAlexander BitadzeAndrea BizzetiThomas BlakeFrederic BlancJonah Evan BlankSteven BluskVladimir BocharnikovJulian Alexander BoelhauveOscar Boente GarciaThomas BoettcherAbhishek BohareAlexey BoldyrevCarolina BolognaniRiccardo BolzonellaRiccardo BonacciNikolay BondarAleksandar BordeliusFederica BorgatoSilvia BorghiMartino BorsatoJozef Tomasz BorsukElia BottalicoSonia Amina BouchibaMarcelo BovillThemistocles BowcockAlexandre BoyerConcezio BozziJames Daniel BrandenburgAlexandre Brea RodriguezNils BreerJolanta BrodzickaJames David BrownDavide BrunduEmma BuchananMarta Burgos MarcosAodhan Tomas BurkeChristopher BurrClarissa ButiJordy Sebastiaan ButterJan BuytaertWiktor ByczynskiSandro CadedduHao CaiYuman CaiAlois CailletRoberto CalabreseSaul Calderon RamirezLukas CaleficeMarta CalviMiriam Calvo GomezPatricia Camargo MagalhaesJose Ivan Cambon BouzasPierluigi CampanaAngel Fernando Campoverde QuezadaSimone CapelliMarco CaporaleLorenzo CapriottiRonald Gerardo Caravaca-MoraAngelo CarboneLidia Carcedo SalgadoRoberta CardinaleAlessandro CardiniPaolo CarnitiLeon David CarusAdrian Casais VidalRowina CasparyGianluigi CasseMarco CattaneoGiovanni CavalleroViola CavalliniSara CelaniIrene CelestinoSara CesareAbbie Jane ChadwickIbrahim ChahrourHao ChangMatthew CharlesPhilippe CharpentierEvridki ChatzianagnostouRacha CheaibMaximilien ChefdevilleChen ChenJou-An ChenShanzhen ChenZewen ChenAlex Chen HuMostafa CherifAleksei ChernovSerhii ChernyshenkoXenofon ChiotopoulosVeronika ChobanovaMarcin ChrzaszczAleksei ChubykinVladimir ChulikovPaolo CiambroneXabier Cid VidalGregory CiezarekPierfrancesco CifraPeter ClarkeMarco ClemencicHarry CliffJoel ClosierCarlos Eduardo Cocha ToapaxiVictor CocoJulien CoganEric CognerasLucian CojocariuSpencer Edward CollavitiPaula CollinsTommaso ColomboMarco ColonnaAlbert Comerma-MontellsLiliana CongedoJames ConnaughtonAndrea ContuNaomi CookeGiulio CordovaChristian Andres CoronelImanol CorredoiraAnthony CorreiaGloria CortiJozie Cottee MeldrumBenjamin CouturierDaniel Charles CraikMelissa Maria Cruz TorresEsteban Curras RiveraRobert CurrieCesar Luiz da SilvaShakhzod DadabaevXinchen DaiElena Dall'OccoJeremy DalsenoCarmelo d'AmbrosioJessy DanielGabriella DarzeAlexander DavidsonJonathan Edward DaviesOscar de Aguiar FranciscoCamilla de AngelisFederico de BenedettiJan de BoerKristof de BruynStefano de CapuaMichel de CianUlisses de Freitas Carneiro da GracaErika de LuciaJussara de MirandaLeandro de PaulaMarilisa de SerioPatrizia de SimoneFabio de VellisJacco de VriesFrancesco DebernardisDaniel DecampSam Michael DekkersLuigi del BuonoBlaise DelaneyHans Peter DembinskiJianqiao DengVadym DenysenkoOlivier DeschampsFrancesco DettoriBiplab DeyPasquale Di NezzaIgor DiachkovSergey DidenkoShuchong DingYiyang DingLucas DittmannVasyl DobishukAleksandrina DochevaAlex Patrick DohenyChenzhi DongAmanda May DonohoeFrancesca DordeiAlberto dos ReisAndrew Jay DowlingLea Marie Sophie DreyfusWeisong DuanPiotr Jakub DudaLaurent DufourViacheslav DukPaolo DuranteMaciej DurasJohn Matthew DurhamOzgur DurmusAgnieszka DziurdaAlexey DzyubaSajan EasoEllinor EcksteinUlrik EgedeArtem EgorychevVictor EgorychevStephan EisenhardtEnoch EjopuLars EklundMohamed ElashriDaniel Guillermo Elizondo BlancoJan Hendrik EllbrachtScott ElyAlexandru EneJonas Nathanael EschleSevda EsenTimothy EvansFederica FabianoSaba FaghihLucas FalcaoBo FangRiccardo FantechiLisa FantiniMaria FariaKeira Gwyn FarmerFloris Patrick Jan FassinDavide FazziniLukasz Jerzy FelkowskiMingjie FengAlvaro Fernandez CasaniMiguel Fernandez GomezAlex Daniel FernezFabio FerrariFernando Ferreira RodriguesMartina FerrilloMassimiliano Ferro-LuzziSergey FilippovRosa Anna FiniMassimiliano FioriniMiroslaw FirlejKamil Leszek FischerDillon Scott FitzgeraldConor FitzpatrickTomasz FiutowskiFrederic FleuretAlex FominMarianna FontanaLucas Arthur ForemanRoger FortyDaniel Foulds-HoltVinicius Franco LimaManuel Franco SevillaMarkus FrankEdoardo FranzosoGiulia FrauChristoph FreiDavid Anthony FridayJinlin FuQuentin FühringTommaso FulghesuGiuliana GalatiMaria Domenica GalatiAbraham Gallas TorreiraDomenico GalliSilvia GambettaMiriam GandelmanPaolo GandiniBilal Ahmad GanieHan GaoRui GaoTian-Qi GaoYang GaoYuanning GaoYuxi GaoLuis Miguel Garcia MartinPaula Garcia MorenoJulián García PardiñasParker Taittinger GardnerLluis GarridoClara GasparArsenii GavrikovLouis Lenard GerkenEvelina GersabeckMarco GersabeckTimothy GershonSimon GhizzoZahra GhorbanimoghaddamFotis Ioannis GiasemisValerie GibsonHenryk Karol GiemzaAlexander Leon GilmanMatteo GiovannettiAlessandra GioventùLucas George GirardeyMaciej Artur GizaFabian Christoph GlaserVladimir GligorovCarla GöbelLarysa Golinka-BezshyykoElisabet GolobardesDmitry GolubkovAndrey GolutvinSergio Gomez FernandezWojciech GomulkaIsadora Gonçales VazFernanda Goncalves AbrantesMateusz GoncerzGuanghua GongJames Andrew GoodingIgor Vladimirovich GorelovClaudio GottiEkaterina GovorkovaJascha Peter GrabowskiLuis Alberto Granado CardosoEugeni GraugésElena GraveriniLuke GrazetteGiacomo GrazianiAlexandru Tudor GrecuNathan Allen GrieserLucia GrilloSergey GromovChenxi GuMarco GuariseLaetitia GuerryAbdul-Kerim GuseinovEvgeny GushchinYury GuzThierry GysKai Sebastian HabermannThomas HadavizadehChristos HadjivasiliouGuido HaefeliChristophe HaenSamuel James HakenGeorge HallettPhoebe Meredith HamiltonJan HammerichQundong HanXiaoxue HanStephanie Hansmann-MenzemerLei HaoNeville HarnewThomas James HarrisMarie HartmannSabin HashmiJibo HeNathan Barry HeatleyAndreea-Irina HedesFrederic HemmerConor HendersonRaoul HendersonRiley Dylan Leslie HendersonArthur Marius HennequinKarol HennessyLouis HenryJames Daniel HerdPaula Herrero GasconJohannes HeuelAnna-Maria HeynAdlène HicheurGuillermo Hijano MendizabalJoshua Ethan HorswillRuiwen HouYingrui HouDylan Cameron HoustonNed Francis HowarthWenhua HuXiaofan HuWouter HulsbergenRoss John HunterMikhail HushchynDavid HutchcroftMarek IdzikDmitrii IlinPhilip IltenAleksandr IniukhinAxel IohnerArtur IshteevKuzma IvshinHendrik JageSergio Javier Jaimes EllesSune JakobsenTomas JakoubekEddy JansBrij Kishor JashalAbolhassan JawaheryChanka JayaweeraVukan JevticZekun JiaEmily Kaiyin JiangXiaojie JiangYi JiangYuyang JiangEsteban Jimenez MoyaNicholas JindalMalcolm JohnAllen Cris John Rubesh RajanDaniel JohnsonChristopher JonesSalil JoshiBeat JostJuan Jose Juan CastellaNathan JurikIzabela JuszczakKamila Karina KalecinskaDimitrios KaminarisSergii KandybeiMichael James KaneYouen KangChandiprasad KarMatthias KaracsonAnni KauniskangasJacob William KautzMichal Krzysztof KazaneckiFloris KeizerMatthew KenzieTjeerd KetelBasem KhanjiAnastasiia KharisovaSergei KholodenkoGaelle KhreichThomas KirnVeronica Soelund KirsebomSuzanne KlaverNico KleijneAlina KleimenovaDenys KlekotsKonrad KlimaszewskiMateusz Rafal KmiecTobias Krischan KnospeRuben KolbSerhii KoliievLars KolkAnatoly KonoplyannikovPawel KopciewiczPatrick KoppenburgAlexander KorchinMikhail KorolevIgor KostiukOleksander KotSofia KotriakhovaElizabeth Marie KowalczykAnastasiia KozachukPolina KravchenkoLeonid KravchukOleg KravcovMichal KrepsPavel KrokovnyWojciech KrupaWojciech KrzemienOleksandr KshyvanskyiSebastian Antoni KubisMarcin KucharczykVasily KudryavtsevEvgenia KulikovaAndrzej KupscVolodymyr KushnirBogdan KutsenkoJakub KvapilIgor KyryllinDaniel LacarrerePaloma Laguarta GonzalezAdriano LaiAndrea LampisDavide LancieriniClara Landesa GomezJohn Jake LaneGaia LanfranchiChristoph LangenbruchJan LangerThomas LathamFederico LazzariCristina LazzeroniRenaud Le GacHo Sang LeeRegis LefèvreAlexander LeflatSergey LegotinMarion LehurauxEdgar Lemos CidOlivier LeroyTadeusz LesiakEzra Douglas LesserBlake LeveringtonAnfeng LiChen LiChing-Hua LiHengne LiJiuzhao LiKechen LiLanxing LiManshu LiPeilian LiPei-Rong LiQinze LiTiange LiTianqi LiYanru LiYiming LiYujie LiZhengchen LianQiming LiangXixin LiangZhihua LiangSimone LibralonAlisha LightbodyChuangxin LinTai-Hua LinRolf LindnerHenry James LintonRoman LitvinovDuanqing LiuFrank Xiangyu LiuGuoming LiuKai LiuShuaiyi LiuWeijie LiuYiming LiuYing LiuYiwei LiuGustavo Alejandro Loachamin OrdonezIsaac Graciano LoboAniol Lobo SalviaAngelo LoiThomas LongFelipe Cesario Laterza LopesJose LopesAlbert Lopez HuertasCristina Lopez IribarnegaraySaúl López SoliñoQiuchan LuChiara LucarelliDonatella LucchesiMiriam Lucio MartinezYiheng LuoAnna LupatoEleonora LuppiKate LynchXiao-Rui LyuGe MaHeng MaSerena MaccoliniFrederic MachefertFlorin MaciucBridget MackInnes MackayLauren Grace MackeyLakshan Ram Madhan MohanMarcus Jonathan MaduraiDaniel MagdalinskiDmitrii MaisuzenkoJakub Jacek MalczewskiSneha MaldeLorenzo MalentaccaAlexander MalininTimofei MaltsevGiulia MancaGiampiero MancinelliChiara MancusoRafel Manera EscaleroFederico ManganellaDaniele ManuzziDaniele MarangottoJean François MarchandRadoslav MarchevskiUmberto MarconiEdoardo MarianiSaverio MarianiCarla Marin BenitoJörg MarksAlexander Mclean MarshallLucas MartelGabriele MartelliGiuseppe MartellottiLoris MartinazzoliMaurizio MartinelliDaniel Guillermo Martinez GomezDiego Martinez SantosFernando Martinez VidalAlexia Martorell GranollersAndré MassafferriRosen MatevAbhijit MathadViacheslav MatiuninClara MatteuzziKara Renee MattioliAndrea MauriEmilie MauriceJoan MauricioPierre Paul Louis MayencourtJose Mazorra de CosMichal MazurekMichael MccannNiall Thomas MchughAndrew McnabRonan McnultyBrian MeadowsGerwin MeierDmytro MelnychukDiego Mendoza GranadaPablo Eduardo Menendez Valdes PerezFanjie MengMarcel MerkAndrea MerliLucas Meyer GarciaDexing MiaoHan MiaoMikhail MikhasenkoDiego Alejandro MilanesAlessandro MinottiElisa MinucciTristan MirallesBiljana MitreskaDominik Stefan MitzelRoxana Maria MocanuAtanu ModakLeandra MoeserRazvan-Daniel MoiseEsteban Felipe Molina CardenasTitus MombächerMatthew David MonkTobias Alexandre MonnardStephane MonteilAngel Morcillo GomezGianfranco MorelloMichael Joseph MorelloMaurice Pierre MorgenthalerAlice MoroJakub MoronWouter MorrenAdam Benjamin MorrisAndrew George MorrisRaymond MountainZeqing MuEmir MuhammadFranz MuheimMick MulderKatharina MüllerFederico Muñoz-RojasRebecca MurtaViktor MytrochenkoParas NaikTatsuya NakadaRaja NandakumarTara NanutGauri NapoletanoIrina NastevaMatthew NeedhamEvgeniia NekrasovaNicola NeriSebastian NeubertNiko NeufeldPetr NeustroevJanina NicoliniDavide NicotraElisabeth Maria NielNikolay NikitinLorenzo NisiQile NiuPedro NogarolliPiet NoggaCamille NormandJulio Novoa FernandezGabriel Matthew NowakCynthia NunezHavva Hasret NurAgnieszka 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• Organismes : Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : A search for $K_{\mathrm{S(L)}}^{0} \rightarrow π^{+}π^{-}μ^{+}μ^{-}$ decays is performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of $13\,\mathrm{TeV}$, corresponding to an integrated luminosity of $5.4\,\mathrm{fb^{-1}}$. No $K_{\mathrm{S(L)}}^{0} \rightarrow π^{+}π^{-}μ^{+}μ^{-}$ signals are found and upper limits are set for the first time on the branching fractions $\mathcal{B}(K_\text{S}^{0} \rightarrow π^{+}π^{-}μ^{+}μ^{-}) < 1.4 \times 10^{-9}$ and $\mathcal{B}(K_\text{L}^{0} \rightarrow π^{+}π^{-}μ^{+}μ^{-}) < 6.6 \times 10^{-7}$, at the 90% confidence level.

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 20/11/2025
• Auteurs : Vladimir ChekhovskyAram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerSuman ChatterjeeKonstantinos DamanakisMarko DragicevicPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonThomas van LaerPierre van MechelenNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongSteven LowetteInna MakarenkoDenise MüllerStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoClaudio CaputoJerome de Favereau de JeneretChristophe DelaereIzzeddin Suat DonertasAndrea GiammancoAhmet Oguz GuzelSandhya JainVincent LemaitreJindrich LidrychPaola MastrapasquaTu Thong TranSemra TurkcaparGilvan AlvesEduardo CoelhoGilson Correia SilvaCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorMapse Barroso Ferreira FilhoHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaTulio Laux KuhnMatheus MacedoJordan MartinsKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielCesar Augusto BernardesLuigi CalligarisThiago TomeiEduardo de Moraes GregoresIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevRoumyana HadjiiskaPlamen IaydjievMilena MishevaMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovElton ShumkaSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurTongguang ChengTahir JavaidLi YuanZhen HuZhengchen LiangJinfeng LiuGuo-Ming ChenHe-Sheng ChenMingshui ChenFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoZhenan LiuRamkrishna SharmaJia-Ning SongJunquan TaoChu WangJin WangZebing WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinXiaohu SunDayong WangHeng YangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerBolin LiHui WangKai YiJingqing ZhangYuji LiZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge 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Madhusudanan SreekalaAbhishikth MallampalliAbdollah MohammadiSusmita MondalGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinDzmitry BudkouskiIgor GolutvinIlya GorbunovVladimir KarjavineOlga KodolovaVladimir KorenkovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaVitaly SmirnovOleg TeryaevNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinGenady GavrilovVictor GolovtcovYury IvanovVictor KimVictor MurzinVadim OreshkinDmitry SosnovValentin SulimovLev UvarovAlexey VorobyevYuri AndreevAlexander DermenevSergei GninenkoNikolai GolubevAnton KarneyeuDmitrii KirpichnikovMikhail KirsanovNikolai KrasnikovIrina TlisovaAlexander ToropinTagir AushevKirill IvanovVladimir GavrilovNatalia LychkovskayaVladimir PopovAlexander ZhokinRuslan ChistovMikhail 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• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Laboratoire d'Annecy de Physique des Particules

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Résumé : A measurement of the substructure of bottom quark jets (b jets) in proton-proton (pp) collisions is presented. The measurement uses data collected in pp collisions at $\sqrt{s}$ = 5.02 TeV recorded by the CMS experiment in 2017, corresponding to an integrated luminosity of 301$^{-1}$. An algorithm to identify and cluster the charged decay daughters of b hadrons is developed for this analysis, which facilitates the exposure of the gluon radiation pattern of b jets using iterative Cambridge-Aachen declustering. The soft-drop-groomed jet radius, $R_\mathrm{g}$, and momentum balance, $z_\mathrm{g}$, of b quark jets are presented. These observables can be used to test perturbative quantum chromodynamics predictions that account for mass effects. Because the b hadron is partially reconstructed from its charged decay daughters, only charged particles are used for the jet substructure studies. In addition, a jet fragmentation function, $z_\text{b,ch}$, is measured, which is defined as the distribution of the ratio of the transverse momentum ($p_\mathrm{T}$) of the partially reconstructed b hadron with respect to the charged-particle component of the jet $p_\mathrm{T}$. The substructure variable distributions are unfolded to the charged-particle level. The b jet substructure is compared to the substructure of jets in an inclusive jet sample that is dominated by light-quark and gluon jets in order to assess the role of the b quark mass. A strong suppression of emissions at small $R_\mathrm{g}$ values is observed for b jets when compared to inclusive jets, consistent with the dead-cone effect. The measurement is also compared with theoretical predictions from Monte Carlo event generators. This is the first substructure measurement of b jets that clusters together the b hadron decay daughters.

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