Philippe Jean-Pierre

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Liem Binh Luong NguyenLyvia MagloireAlexis FrançoisDavid BillardFrank PriouJennifer ArrondeauClaude LinassierInes Ben GhezalaMarine Gross-GoupilJulie CharlesNadine DohollouPhilippe VanhemsClaire CracowskiAnne Marie LeroiFabrice LainéFlorence GaltierKarine BarthelemyStéphane PrietMariam GharibMathieu ChalouniAude BarquinPaul LoubetXavier de LamballerieOdile LaunayLinda WittkopJean-Yves BlayJean-Philippe Spano
• Organismes : Inserm, F-CRIN, I-REIVAC/COVIREIVAC, 75679 Paris, France. Centre d'Investigation Clinique Cochin Pasteur, Paris, France Centre d'Investigation Clinique Antilles Guyane, Inserm CIC 1424, Fort de France, 97261, Martinique, France Methods and Applied Research for Trial [UNIV Bordeaux] Centre d'Investigation Clinique Antilles Guyane, Inserm CIC 1424, Fort de France, 97261, Martinique, France Methods and Applied Research for Trial [UNIV Bordeaux] Hôpital Foch [Suresnes] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Cancer Research and Personalized Medicine - CARPEM [Paris] Centre Hospitalier Régional Universitaire, 37000 Tours, Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Inserm, F-CRIN, I-REIVAC/COVIREIVAC, 75679 Paris, France. Centre Hospitalier Universitaire [CHU Grenoble] INSERM U1209, équipe Patrice Marche (Immunologie Analytique des Pathologies Chroniques) Polyclinique Bordeaux Nord Aquitaine Hôpital Edouard Herriot [CHU - HCL] Equipe Epidémiologie et Santé Publique Université Claude Bernard Lyon 1, Lyon, France. Centre d'Investigation Clinique [Grenoble] Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Centre d'Investigation Clinique [CHU Rouen] Service de Physiologie Digestive, Urinaire, Respiratoire et de l'Exercice [CHU Rouen] Centre d'Investigation Clinique [Rennes] Hôpital Sud [CHU Rennes] CIC Montpellier Unité des Virus Emergents Unité des Virus Emergents ANRS - Maladies infectieuses émergentes Methods and Applied Research for Trial [UNIV Bordeaux] Methods and Applied Research for Trial [UNIV Bordeaux] Plateforme F-CRIN INSERM U1047 Unité des Virus Emergents Plateforme F-CRIN Methods and Applied Research for Trial [UNIV Bordeaux] Centre d’Investigation Clinique de Bordeaux Centre de Recherche en Cancérologie de Lyon Environnement, Mobilité et Santé [iPLesp] Assistance publique - Hôpitaux de Paris (AP-HP)
• Publié dans Vaccine le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Antoine GavoilleMikaïl NourredineFabien RollotRomain CaseyGuillaume MatheyAnne KerbratJonathan CironJérôme de SèzeBruno StankoffEdouard JanuelAurélie RuetPierre M LabaugeArnaud KwiatkowskiHélène ZéphirCaroline PapeixGilles-Louis DeferChristine Lebrun-FrénayThibault MoreauDavid-Axel LaplaudEric BergerPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagySolène MoulinJean-Philippe CamdessanchéInès DoghriMariana SarovKarolina HankiewiczCorinne PottierAmélie dos SantosÉric ManchonMaia TchikviladzeMuriel RabilloudFabien SubtilSandra Vukusic
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique [Nancy] Service de neurologie [Rennes] Neuroimagerie: méthodes et applications Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de Neurologie [Strasbourg] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hôpital Saint Vincent de Paul [Lille] Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université Paris Cité Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Service de Neurologie [CHU Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Service de Neurologie [CHRU Besançon] Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Hôpital Henri Mondor Service de Neurologie [CHU Limoges] Service de neurologie [Reims] Service de Neurologie [CHU de Saint-Étienne] Hôpital Bretonneau Service de neurologie [Le Kremlin Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] hôpital NOVO Service de neurologie [CHU de Poitiers] CIC Poitiers – Centre d'investigation clinique de Poitiers Centre Hospitalier de Gonesse Hôpital Foch [Suresnes] Alte University [Tbilissi] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Hospices Civils de Lyon Fondation Eugène Devic EDMUS
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

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Résumé : Background: Target trial emulation (TTE) offers a formal framework for causal inference using observational data, but its validity must be evaluated in each research domain by replicating randomised clinical trials (RCTs). We aimed to replicate eight RCTs evaluating the efficacy of disease-modifying therapies (DMTs) in multiple sclerosis (MS) using French registry data. Methods: This multicentre, retrospective, observational study was conducted using data extracted in December 2023 from the Observatoire Français de la Sclérose en Plaques (OFSEP) database. For each emulated trial, patients were included when they initiated one of the DMT evaluated in the corresponding RCT and met its inclusion criteria. Clinical outcomes were the annualised relapse rate and 3-month confirmed Expanded Disability Status Scale progression. Radiological outcomes were new/enlarged T2-lesions and new gadolinium-enhanced T1-lesions on a brain MRI. A targeted maximum likelihood estimator was used to estimate the treatment effect adjusted for confounding factors between groups and corrected for censoring and missing outcome assessment. Results: 14 111 patients were included in eight emulated trials: ASSESS (fingolimod vs glatiramer acetate), BEYOND (interferon beta vs glatiramer acetate), CONFIRM (dimethyl fumarate (DMF) vs glatiramer acetate), OPERA (ocrelizumab vs interferon beta), REGARD (interferon beta vs glatiramer acetate), RIFUND-MS (rituximab vs DMF), TENERE (teriflunomide vs interferon beta) and TRANSFORMS (fingolimod vs interferon beta). Treatment effects estimated in emulated trials were concordant with RCT findings in seven of eight trials for relapse rate, and in all six trials assessing disability progression. Radiological outcomes were more challenging to replicate; concordance was achieved in three of five trials for new T2-lesions, and one of four trials for new gadolinium-enhanced T1-lesions. Conclusion: The combined use of a TTE methodology and high-quality registry data is a valid tool to evaluate treatment effectiveness in MS.

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Fichiers liés : Gavoille et al 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/08/2025
• Auteurs : David Messika-ZeitounMichael W.A. ChuDenis BouchardThierry Le TourneauJulien TernaclePhilippe DemersLinrui GuoAngel Yi Nam FuJean Claude DibCharmaine LamThays SokolovAmedeo AnselmiDidier TchétchéOphélie Brault MeslinAnge GoutondjiYoan Lavie-BadiePatrick SeknadjiAugustin CoisneDimitri ArangalageAnne BernardUsha ManianMalek KassAntonio FioreArnaud MaudiereYohann BohbotAurélien SeemannNadjib HammoudiLoïc BièrePierre-Yves LerouxJessica ForcilloAntoine JeuBenjamin ElegamandjiChristine Selton-SutyMartine GilardClaire BouletiOmair ArshadJean-Francois LegareThiziri Si MoussiJian YeCatherine SportouchBindu BittiraLaura MunteFabrice BauerGeraldine OngAli Fatehi HassanabadJordan BernickGeorge WellsRoja GaudaBernard IungWilliam D.T. KentJean-François ObadiaJulien DreyfusChristophe TribouilloyGilles TouatiLoïc BièreOlivier FouquetFrédéric RouleauDimitri ArangalageBernard IungJulien TernacleGuillaume BonnetThomas ModineJules HagerPierre GravinayMartine GilardAnge GoutondjiOlivier BouchotAline JazayeriAntonio FiorePascal LimThierry FolliguetLaura MunteAlain BerrebiPaul AchouhThiziri Si MoussiNadhir ChabanAugustin CoisneMarie JunglingCédric Robert-ValliThays SokolovMarco VolaJean-François ObadiaChristine Selton-SutyRomain MaheutOlivier HuttinThierry Le TourneauThomas SenageJean-Christian RousselNadjib HammoudiGuillaume LebretonPaul-Jun MartialClaire BouletiBenjamin AlosSonia AzzakaniAmedeo AnselmiGiuseppe EvangelistaErwan DonalFabrice BauerChadi AludaatYoan Lavie-BadieFlavie AbadieBertrand MarcheixAnne BernardAntonin FuzeauThierry BourguignonBenjamin ElegamandjiMohammed NejjariJulien DreyfusJean Claude DibCatherine SportouchStéphane CadeJean Etienne RicciPierre-Yves LerouxVincent DoisyDidier TchétchéMauro BoiagoLaurent LepageOmar OlivaAurélien SeemannOphélie Brault-MeslinAlain BerrebiPatrick SeknadjiMarine JullienEdouard BalloutArnaud MaudiereRemi HouelAntoine JeuOmair ArshadDavid HarnettJean-Francois LegareJessica ForcilloPhilippe DemersMichel PellerinDenis BouchardBindu BittiraLinrui GuoShahar LaviMichael ChuUsha ManianJennifer HigginsGeraldine OngNeil FamHoward Leong-PoiAngel Yi Nam FuDavid Messika-ZeitounVincent ChanJordan BernickGeorge WellsRoja GaudaMalek KassSteven PromislowAli Fatehi HassanabadCorey AdamsWilliam KentJian YeCharmaine LamChristina LuongMohammad Al-Fadhalah
• Organismes : University of Ottawa Heart Institute Montreal Heart Institute - Institut de Cardiologie de Montréal Institut du Thorax [CHU Nantes] CHU de Bordeaux Pellegrin [Bordeaux] Montreal Heart Institute - Institut de Cardiologie de Montréal Western University [London, ON, Canada] University of Ottawa Heart Institute Hospices Civils de Lyon Centre Hospitalier Universitaire [Rennes] Laboratoire Traitement du Signal et de l'Image Clinique Pasteur [Toulouse] Institut Mutualiste de Montsouris CHU Dijon Centre Hospitalier Universitaire de Toulouse Hôpital Privé Jacques Cartier [Massy] Centre Hospitalier Régional Universitaire [CHU Lille] Laboratoire de Recherche Vasculaire Translationnelle Centre Hospitalier Régional Universitaire de Tours Membrane Signalling and Inflammation in reperfusion Injuries Hôpital Henri Mondor Cardiologie [CHU Amiens] Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 TRANSCOV-study group CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire d'Angers Médipôle Lyon-Villeurbanne Hôpital Privé Le Bois Ramsay Santé [Lille] Centre Hospitalier Universitaire de Nancy Hôpital Maison Blanche Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Clinique du Millénaire - Oc Santé [Montpellier] Hôpital Européen Georges Pompidou [APHP] Hôpital Charles Nicolle [Rouen] University of Toronto University of Ottawa Heart Institute University of Ottawa [Ottawa] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Laboratoire de Recherche Vasculaire Translationnelle University of Calgary Hospices Civils de Lyon Centre cardiologique du Nord Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 Service de Cardiologie [Amiens] Centre Hospitalier Universitaire d'Angers Laboratoire de Recherche Vasculaire Translationnelle CHU de Bordeaux Pellegrin [Bordeaux] Hôpital Maison Blanche CHU Dijon Hôpital Henri Mondor Hôpital Européen Georges Pompidou [APHP] Centre Hospitalier Régional Universitaire [CHU Lille] Hospices Civils de Lyon Hospices Civils de Lyon Centre Hospitalier Universitaire de Nancy Institut du Thorax [CHU Nantes] CHU Pitié-Salpêtrière [AP-HP] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Universitaire [Rennes] Laboratoire Traitement du Signal et de l'Image Hôpital Charles Nicolle [Rouen] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Régional Universitaire de Tours Membrane Signalling and Inflammation in reperfusion Injuries Clinique du Millénaire - Oc Santé [Montpellier] Médipôle Lyon-Villeurbanne Clinique Pasteur [Toulouse] TRANSCOV-study group Hôpital Privé Jacques Cartier [Massy] Hôpital Privé Le Bois Ramsay Santé [Lille] Montreal Heart Institute - Institut de Cardiologie de Montréal Montreal Heart Institute - Institut de Cardiologie de Montréal Western University [London, ON, Canada] University of Toronto University of Ottawa Heart Institute University of Ottawa Heart Institute
• Publié dans Circulation le 29/10/2020

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Résumé : Background: Comprehensive knowledge of the clinical presentation, contemporary management, and outcomes on "allcomer" patients referred for mitral valve surgery (MVS) are critical to evaluate current practice and adherence to guidelines, understand selection biases, and inform key stakeholders on quality improvement. Methods: MITRACURE is a large international retrospective registry of consecutive adult patients who underwent isolated or combined MVS for mitral regurgitation (MR) in France or Canada in 2019 with in-depth clinical and echocardiographic characterization. Patients operated on for isolated mitral stenosis or who had a prior mitral valve intervention were excluded. Data were obtained from detailed chart abstraction and were site reported. Results: In 2019, 3522 patients underwent MVS (48% combined) across 40 centers (88±46 MVSs/center, median 80, interquartile [51–131]). Mean age was 65±12 years, and 35% were women. The most common MR etiology was myxomatous (61%), followed by functional (9%), infective endocarditis (9%), and rheumatic disease (7%). MR quantification was performed in only 43%. Advanced clinical presentation was common: 43% were in New York Heart Association class III/IV, 30% exhibited congestive heart failure, 47% were on diuretics, 22% had atrial fibrillation/flutter, 35% presented with reduced ejection fraction, and 22% had pulmonary hypertension (≥50 mm Hg). Most patients were symptomatic or presented with class I/IIa indication for intervention, and an early intervention was performed only in 3% of patients. The repair rate was 62% overall and 80% in myxomatous disease. In-hospital mortality was 4.5% overall but 2.3% in patients with myxomatous MR (1.8% isolated, 3.1% combined). Conclusions: MITRACURE provides a contemporary, multicenter, "real-world" picture of the clinical presentation, management, and in-hospital outcomes of MVS for MR in two Western countries. Patients were often referred late in the disease process, with few patients undergoing early intervention. The higher mortality and lower repair rates reported may be more reflective of an unselected MR patient population but have room for improvement. Our results underline the need to develop strategies to improve management and outcomes of patients with MR.

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2025
• Auteurs : Jean-Guillaume DillingerThéo PezelLaure BatiasDenis AngoulvantMarc GoralskiEmile FerrariGuillaume CaylaJohanne SilvainMartine GilardGilles LemesleGéraud SouteyrandPascal LimFrançois RoubilleJean-Louis GeorgesClaire Bal Dit SollierThibaut PetroniOlivier MorelNicolas DelarcheMeier ElbazEtienne PuymiratSolenn ToupinGilles MontalescotLudovic DrouetÉric VicautPatrick HenryVictor AboyansAngoulvant DenisBatias LaureBelle LoicBellemain-Appaix AnneBenamer HakimBeygui FarzinBihry NicolasBonnefoy-Cudraz EricBrunel PhilippeCarrie DidierCayla GuillaumeChague FrédéricCoste PierreCottin YvesCuisset ThomasDelarche NicolasDerimay FrançoisDib Jean ClaudeDillinger Jean-GuillaumeDucrocq GregoryElbaz MeyerFerrari EmileGeorges Jean-LouisGilard MartineGoralski MarcGoube PascalHauguel-Moreau MarieHenry PatrickHoussany-Pissot SoniaLebreton HervéLemesle GillesLim PascalMaillard LoicMitchell-Heggs LaurensMontalescot GillesMorel OlivierPetroni ThibaultPezel ThéoPrunier FabricePuymirat EtienneRoubille FrançoisSanguineti FrancescaSchiele FrançoisSilvain JohanneSouteyrand GeraudSteg Philippe GabrielTron ChristopheVarenne Olivier
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Institut Parisien de Recherche Architecture Urbanistique Société
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Abstract Background and Aims Despite current antithrombotic treatments, the recurrence of ischaemic events remains high in patients with diabetes mellitus (DM) or aspirin resistance after acute coronary syndrome (ACS). Whether twice-daily aspirin dosing reduces major adverse cardiovascular events (MACE) in this population remains unknown. Methods In this prospective multicentre, randomized trial, patients with ACS and DM or high-risk of aspirin resistance (HRAR) defined as: (i) an index event occurring while on aspirin; (ii) body mass index ≥27 kg/m2; or (iii) increased waist circumference were assigned to receive enteric-coated aspirin once daily (100 mg/day) or twice daily (100 mg morning and evening). The primary outcome was MACE, a composite of any death, myocardial infarction, stroke, urgent coronary revascularization, stent thrombosis, or acute arterial thrombotic event assessed using a time-to-first-event analysis. The main secondary outcome was major bleeding (Bleeding Academic Research Consortium type 3–5). Results In total, 2484 participants were enrolled (77.2% with DM, 55.5% with ST-elevation segment myocardial infarction). The median follow-up duration was 18 (interquartile range: 17.6–18.3) months. The primary outcome occurred in 95 of 1228 participants (7.7%) in the twice-daily aspirin group, and 110 of 1256 (8.8%) in the once-daily group (hazard ratio [HR] 0.90; 95% confidence interval [CI] 0.69–1.19; P = .42). Major bleeding rates were similar between the groups (1.9% vs 2.1%; HR 0.88; 95% CI 0.50–1.55). Conclusions In patients with ACS and DM or HRAR, twice-daily aspirin did not significantly reduce the risk of MACE compared to once-daily dosing. No significant difference was observed in major bleeding between groups. Trial Registration NCT02520921/EUDRACT No: 2015-000947-18.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/08/2025
• Auteurs : Vincent GuiraudAntoine FauchoisCathia SouliéValentin LeducqMarianne VeyriLambert AssoumouDavid BoutolleauDominique CostagliolaOlivier LambotteJean-Philippe SpanoValérie PourcherAnne-Geneviève MarcelinVincent Calvez
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Antibodies to programmed cell death 1 (PD-1), Programmed death-ligand 1 (PDL-1) and Cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4) can revert HIV latency and enhance anti-HIV cytotoxic response but their impact on HIV proviral sequences and integration landscape in people with HIV (PWH) remain to be studied. Two PWH treated with PD-1/PDL-1 and one with PD-1/CTLA4 were studied among the ANRS-CO-24 OncoVIHAC cohort study. Matched integration site and proviral sequencing were performed pre-and post-treatment. Immune checkpoint inhibitors (ICI) were not associated with significant changes in total cellassociated HIV-DNA, nor significant changes in genomic or epigenetic features of integration sites. ICIs were associated with a lesser proportion of proviruses with pol frameshifts for all regimen, with the PD-1 and PD-1/CTLA4 patients also experiencing a higher proportion of proviral sequences harboring gag frameshifts and a higher number of STOP codons, consistent with a gag-driven immune clearance. ICI use were consistently associated with a limited reduction in the HIV-reservoir diversity. Finally, the patient with a PD-1/CTLA4 treatment exhibited the loss of an HIV-clone in the NIN-oncogene representing 17% of all his pre-treatment sequences. Despite stable levels of cell-associated HIV DNA, ICI treatment can lead to modest changes in proviral sequence landscapes.

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Fichiers liés : OncoVIHAC-papier-revised-unmarked.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/08/2025
• Auteurs : Tomaso BeringheliClément JavauxSandrine RouxEvelyne BraunPierre ChauvelotSylvain GoutelleThomas BriotJudith CottinCéline DupieuxJohanna BoulantAnne ConradFlorence AderTristan FerryFlorent ValourTristan FerryTristan FerryFlorent ValourClaire Triffault-FilitAgathe BeckerAnne ConradEvelyne BraunFlorence AderIsabelle EberlJoanna-Isabelle Kurban Bessa LippmanLorena Van-Den-BogaartMarie SimonOlivier BahuaudPierre ChauvelotSandrine RouxSarah SouegesSophie LandreThomas PerpointClément JavauxMarie WanCécile BataillerSébastien LustigElvire ServienGerald DelfosseGuillaume MesnardJean BaltzerJulien ErardNicolas CanceSébastien MartresFranck TrouilletStanislas GunstAlexandre CouraudonAnthony VisteFabien EwaldJean-Luc BesseMatthieu CotteMichel FessyPhilippe ChaudierThomas CuinetVianney DerreveauxAntoine BertaniAntoine ColasFrédéric RongierasJean-Baptiste MassonLéonard VézoleMaxime RarchaertVincent PibarotAram GazarianArnaud WalchChristophe GaillardGaetan VanpoulleLouis DucharneLyliane LyNael Ben-HadidSelma LahlaliThibault DruelVictor RutkaAlain-Ali MojallalAbdulrahman HashimGuillaume HenryHélène PersonMathilde LhermAudrey Chevreau-CilibertiCaroline MacabéoFrédéric AubrunKaissar RouhanaMikhail DziadzkoCéline DupieuxTiphaine Roussel-GaillardLaetitia BeraudMatthieu Curtil-Dit-GalinAni HorikianAnne-Lise MaucotelCamille KolendaJean-Philippe RasigadeAlexis TrecourtDavid GicquelGrégoire VervustIsabelle MorelecJean-Baptiste PialatJoris LavigneNicolas StacoffeAgnes HenryNoémie VieuxRomain GarreauThomas BriotSylvain GoutelleJohanna Boulant
• Organismes : Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Lyon Bone and Joint Infection Study Group Hospices Civils de Lyon Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques Hospices Civils de Lyon Evaluation et modélisation des effets thérapeutiques [LBBE] Université Claude Bernard Lyon 1 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique Hospices Civils de Lyon Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI] Centre International de Recherche en Infectiologie Pathogenèse des légionelles- Legionella pathogenesis [CIRI] Hospices Civils de Lyon Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Centre International de Recherche en Infectiologie Pathogenèse des légionelles- Legionella pathogenesis [CIRI] Lyon Bone and Joint Infection Study Group Centre International de Recherche en Infectiologie Hospices Civils de Lyon Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Background and objectives Due to its potentially better long-term haematologic tolerance compared to linezolid, tedizolid represents an attractive option for prolonged antibiotic therapy in complicated/chronic Gram-positive infections. However, there is little information regarding the risk of peripheral neurological toxicity, representing another obstacle to the extended use of oxazolidinones. Reporting neurologic adverse events occurring during tedizolid therapy for chronic implant-associated infections. Patients and methods Patients experiencing tedizolid-associated neurologic adverse events were retrospectively described in a case series. Results Five patients (four males; age range, 65–75 years) receiving tedizolid (200 mg q24h) as long-term suppressive therapy for chronic implant-associated infection presented with peripheral neuropathy. In four cases, tedizolid was used after discontinuation of linezolid for toxicity, including one case of neuropathy. Three had at least one additional risk factor for neuropathy (including two diabetes, one of them with diabetes-related nephropathy). Neuropathic symptoms [paraesthesia (n = 2), worsening of pre-existing neuropathy (n = 2), dysesthesias (n = 1)] appeared after a median of 12.4 (IQR, 8.2–13.3) months of tedizolid treatment. Electromyoneurography (EMNG) confirmed axonal sensory polyneuropathy in all but one patient for which EMNG was still within normal ranges, but compatible with incipient neurotoxicity. Tedizolid was stopped in all patients, three patients required specific treatment for neuropathic pain. At last follow-up [2.4 (IQR, 1–2.5) years from tedizolid discontinuation], clinical recovery from neuropathy was noted in three patients. The two patients with persistent neuropathy symptoms were diabetic; one showed EMNG improvement. Conclusions Prolonged used of tedizolid may be associated with peripheral neurologic toxicity, which should be monitored in at-risk patients.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 26/08/2025
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinXiaohu SunDayong WangJin WangHeng YangMingtao ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerBolin LiHui WangKai YiJingqing ZhangYuji LiZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouAndreas HadjiagapiouChristos LeonidouCharalambos NicolaouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerEdy AyalaEdgar Carrera JarrinAhmed Ali AbdelalimReham AlyMuhammad Abdullah Abdulfattah MuhammadAhmed HusseinHemida MohammedKarl EhatahtMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalNorman SeebaLaurits TaniAnna MilievaKenneth OsterbergMikko VoutilainenNurfikri Bin NorjoharuddeenErik BrückenFrancisco Ignacio Garcia 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SokmenLourdes Urda GómezAlexandre ZabiAmina ZghicheJean-Laurent AgramJeremy AndreaDaniel BlochJean-Marie BromEric Christian ChabertCaroline CollardGael CoulonSaskia FalkeUlrich GoerlachRaphael HaeberleAnne-Catherine Le BihanMeena MeenaOceane PoncetGourab SahaPaul VaucelleAdriano Di FlorioDavid AmramStephanie BeauceronBenjamin BlanconGaelle BoudoulNicolas ChanonDidier ContardoPierre DepasseHoumani El MamouniJean FaySusan GasconMaxime GouzevitchChristopher GreenbergGérald GrenierBernard IlleElise Jourd'HuyImad Baptiste LaktinehMorgan LethuillierBenjamin MassoteauLaurent MirabitoArnab PurohitMuriel Vander DoncktJie XiaoIrakli LomidzeTengizi ToriashviliZviad TsamalaidzeValeria BottaSandra Consuegra RodríguezLutz FeldKatja KleinMartin LipinskiDanilo MeuserPhilipp NattlandVanessa OppenländerAlexander PaulsDanyer Pérez AdánNicolas RöwertMarius TeroerdeCaio DaumannSvenja DiekmannAlena DodonovaNiclas EichDmitry EliseevFrederic EngelkeJohannes ErdmannMartin ErdmannBenjamin FischerThomas 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Résumé : Using proton-proton collision data collected by the CMS experiment at $\sqrt{s}$ = 13 TeV in 2016$-$2018, corresponding to an integrated luminosity of 140 fb$^{-1}$, the first full reconstruction of the three vector B meson states, B$^{*+}$, B$^{*0}$, and B$^{*0}_\text{s}$, is performed. The mass differences between the excited mesons and their corresponding ground states are measured to be $m(\text{B}^{*+})-m(\text{B}^+)$ = 45.277 $\pm$ 0.039 $\pm$ 0.027 MeV, $m(\text{B}^{*0})- m(\text{B}^0)$ = 45.471 $\pm$ 0.056 $\pm$ 0.028 MeV, and $m(\text{B}^{*0}_\text{s})-m(\text{B}_\text{s})$ = 49.407 $\pm$ 0.132 $\pm$ 0.041 MeV, where the first uncertainties are statistical and the second are systematic. These results improve on the precision of previous measurements by an order of magnitude.

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