Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 18/12/2024
• Auteurs : Nathalie JustPierre Marie ChevillardMartine BataillerJean-Philippe DuboisPascal VaudinDelphine PillonMartine Migaud
• Organismes : Physiologie de la reproduction et des comportements [Nouzilly] Danish Research Centre for Magnetic Resonance Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly]

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Résumé : The hypothalamus is a central structure of the mammalian brain, which controls physiological, endocrine and metabolic brain homeostasis. Despite this essential role, little is known about the normal and altered neurochemical changes occurring within the hypothalamic structures. Here, the metabolism of the hypothalamus of ewes was investigated at 3T using proton magnetic resonance spectroscopy ( 1 H-MRS). We used the sensitivity of these animals to photoperiod i.e. the ratio of day to night length, to investigate the hypothalamic metabolic changes and their relationship to hypothalamic adult neurogenesis. A longitudinal study involving 4 ewes per timepoint was conducted at 4 time points (P01, P02, P03 and P04) during long days (LD) and 4 time points during short days (SD). Significant metabolic changes were found between LD and SD at all time points in particular for glutamate (Glu), glutamine, myo-inositol and total N-acetyl-Aspartate (NAA). During SD, glutamate and glutamine concentrations were significantly smaller at P01 compared to all other time points while significant neurochemical changes occurred during the entire LD period. Neurochemical changes relative to P01 remained stable during LD and SD except for Glu and Gln which increased between P01 and P02 during SD. Relative metabolic changes were significantly higher on average for NAA and Glu and significantly smaller on average for total choline during SD compared to LD, respectively, paralleling the average changes in the numbers of neural stem cells and glial and oligodendrocyte progenitors found by immunohistochemistry. Despite important differences between MRS and immunohistochemistry in terms of spatial resolution, both techniques suggest complementary findings that should contribute to a better characterization of the hypothalamus during photoperiodism and adult neurogenesis. We conclude that 1 H-MRS could be a promising non-invasive translational technique to investigate the existence of adult neurogenesis in-vivo in gyrencephalic brains.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/12/2024
• Auteurs : Sélim Ben ChéhidaHeemee Devi BunwareeMurielle HoareauOumaima MoubsetCharlotte JulianLaurence BlondinDenis FillouxChristophe LavergnePhilippe RoumagnacArvind VarsaniDarren MartinJean-Michel LettPierre Lefeuvre
• Organismes : Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Plant Health Institute of Montpellier Plant Health Institute of Montpellier Plant Health Institute of Montpellier Plant Health Institute of Montpellier Conservatoire Botanique National de Mascarin Plant Health Institute of Montpellier Arizona State University [Tempe] University of Cape Town Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical
• Publié dans Virus Evolution le 25/01/2017

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Résumé :

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Fichiers liés : Chehida-VE-2024-CC-BY.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2024
• Auteurs : Sophie HennionValentyn FournierPhilippe DerambureGérald DelelisLoris Schiaratura
• Organismes : Lille Neurosciences & Cognition - U 1172 Service de neurophysiologie clinique Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Service de neurophysiologie clinique Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072
• Publié dans Epilepsy & Behavior le 22/10/2020

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Résumé : People with epilepsy face stigma that impacts numerous aspects of their daily lives. Although the stigma surrounding people with epilepsy has been extensively documented, the mechanisms underlying it—such as cultural stereotypes—remain to be explored. Cultural stereotypes are widely shared beliefs within a cultural context about attributes typically associated with members of a particular group. This study, conducted within French society, has two primary objectives: 1) to define the content of cultural stereotypes associated with people suffering from epilepsy and 2) to examine how familiarity and knowledge about epilepsy influence these stereotypes. To explore these stereotypes, a free association task was conducted across three cultural groups (n = 96): (1) the general population, with low familiarity and knowledge about epilepsy (n = 39); (2) healthcare professionals without epilepsy specialization, who have more familiarity and knowledge than the general population (n = 38); and (3) healthcare professionals specialized in epilepsy, who have the highest familiarity and knowledge of the three groups (n = 29). All participants held higher education qualifications to ensure a more homogeneous socio-cultural background across groups. Using the software program “IraMuTeQ”, we analyzed the diversity of terms each group associated with “people with epilepsy.” Additionally, we examined the valence and typicality of cultural stereotypes in each group. The results reveal that, regardless of familiarity and knowledge levels, cultural stereotypes linked to epilepsy are generally negative. Across the entire sample, the most prototypical associations with people with epilepsy included “madness,” “possession,” “tongue,” and “intellectual deficiency.” The general population shares some cultural stereotypes with non-specialized healthcare professionals (e.g., “photosensitivity”), while non-specialized professionals share other associations with specialized healthcare professionals (e.g., “intellectual deficiency” and “mental illness”). However, no overlap was found between the cultural stereotypes of the general population and those of healthcare professionals specialized in epilepsy. Stereotypes related to epilepsy appear to be less typical among healthcare professionals compared to the general population. This distinction between cultural stereotypes and personal beliefs is further discussed below. Considering cultural stereotypes may allow for more tailored and effective interventions to reduce epilepsy-related stigma by addressing specific socio-cultural groups. Further research within a cross-cultural approach is recommended to deepen these findings.

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2024
• Auteurs : Marie RobertAlexis MathianValentin LacombeHervé LobbesLéopold AdélaïdeMaelle Le BesneraisJean-Nicolas DacherBenjamin TerrierArsène MékinianRim BourguibaSophie Georgin-LavialleJérome HadjadjYann NguyenDalila MouloudjMaël HeibligHassina AlouiChloé Mc AvoySamuel ArdoisCorrado CampochiaroAlexandre MariaCyrille CoustalThibault ComontEstibaliz LazaroFrançois LifermannGuillaume Le GuennoVincent GrobostRoderau OuthJulien CampagneAnais Dor-EtienneAlice GarnierYvan JamillouxAntoine DossierMaxime SamsonSylvain AudiaBarbara NicolasBaptiste de MalepradeBenjamin de Sainte MarieBenoit FaucherJean-David BouazizJonathan BronerCyril DumainCarole AntoineBenjamin CarpentierBrice CastelCéline Lartigau-RoussinÉtienne CrickxGeoffroy VolleDamien FayardPaul DeckerThomas MoulinetAnael DumontAlexandre NguyenAchille AoubaJean-Philippe MartellosioMatthieu LevavasseurSébastien PuigrenierPascale AntoineJean-Thomas GiraudOlivier HermineCarole LacoutNihal MartisJean-Denis KaramFrançois ChassetLaurent ArnaudPaola Marianetti GuingelChristophe DelignyThibaud ChazalPascal Woaye-HuneMarielle Roux-SauvatAurore MeyerPierre HirschNoémie AbisrorPierre FenauxOlivier KosmiderVincent JachierOlivier Fain
• Organismes : AP-HP - Hôpital Bichat - Claude Bernard [Paris] CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Centre Hospitalier Universitaire d'Angers CHU Estaing [Clermont-Ferrand] Institut Pascal Centre Hospitalier de Vienne Lucien Hussel Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices Hôpital Charles Nicolle [Rouen] Endothélium, valvulopathies et insuffisance cardiaque CHU Rouen Hôpital Cochin [AP-HP] Université Paris Cité CHU Saint-Antoine [AP-HP] Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) CHU Tenon [AP-HP] Sorbonne Université Assistance publique - Hôpitaux de Paris (AP-HP) Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] CHU Saint-Antoine [AP-HP] Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes Université Claude Bernard Lyon 1 Hospices Civils de Lyon Centre de Recherche en Cancérologie de Lyon CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] IRCCS San Raffaele Scientific Institute [Milan, Italie] CHU Montpellier = Montpellier University Hospital Hôpital Saint Eloi [CHU Montpellier] Service Médecine interne [CHU Toulouse] Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle Centre Hospitalier de Dax CHU Estaing [Clermont-Ferrand] CHU Clermont-Ferrand Centre Hospitalier Saint Jean de Perpignan Université de Lorraine Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers Hôpital de la Croix-Rousse [CHU - HCL] Université Claude Bernard Lyon 1 AP-HP - Hôpital Bichat - Claude Bernard [Paris] Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Imagerie Ultrasonore CHU Rouen Hôpital de la Timone [CHU - APHM] Aix Marseille Université Service des Maladies Infectieuses et Tropicales [CHU Hôpital Nord - Marseille] Immunologie humaine, physiopathologie & immunothérapie Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Université de Montpellier Aix-Marseille Université - École de médecine Hôpital Cochin [AP-HP] Centre Hospitalier de Bigorre [Tarbes] Institut Necker Enfants-Malades Institut Mondor de Recherche Biomédicale Biologie Intégrée du Globule Rouge Institut National de la Transfusion Sanguine [Paris] Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge Service Médecine Interne - site Gabriel-Montpied [CHU Clermont-Ferrand] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Ingénierie Moléculaire, Cellulaire et Physiopathologie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie UNIROUEN - UFR Santé Université de Caen Normandie - UFR Santé Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers = University of Poitiers Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans JAMA Network Open le 29/10/2020

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Résumé : This case series reports on the clinical presentation, laboratory findings, imaging characteristics, treatments, and outcomes of nonischemic cardiac manifestations in patients with VEXAS syndrome with confirmed pathogenic UBA1 alterations.

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Fichiers liés : Vexas_cardiac_JamaNetwork2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2024
• Auteurs : Dominique PloinMathilde AlexandreBruno VentelouDidier CheBruno CoignardNathalie BoulangerChristophe BurucoaFrançois CaronPierre GallianYves HansmannChristian LienhardtPhilippe MinodierHenri PartoucheMathieu RevestNadia SaidaniGilles SalvatNicolas VignierSylvie FloreaniSabine HenryBruno PozzettoBruno Hoen
• Organismes : Hôpital Femme Mère Enfant [CHU - HCL] Center for Interdisciplinary Research and Innovation Commission Spécialisée Maladies infectieuses et maladies émergentes Commission Spécialisée Maladies infectieuses et maladies émergentes Centre National de la Recherche Scientifique Aix Marseille Université Aix-Marseille Sciences Economiques Santé publique France - French National Public Health Agency [Saint-Maurice, France] Santé Publique France, Occitanie [Toulouse, France] Centre National de référence des Borrelia Commission Spécialisée Maladies infectieuses et maladies émergentes Pathogens Host Arthropod Vectors Interfaces Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Commission Spécialisée Maladies infectieuses et maladies émergentes Service des maladies infectieuses et tropicales [Rouen] Dynamique Microbienne associée aux Infections Urinaires et Respiratoires Unité des Virus Emergents Etablissement Français du Sang [La Plaine Saint-Denis] Commission Spécialisée Maladies infectieuses et maladies émergentes Commission Spécialisée Maladies infectieuses et maladies émergentes Centre Hospitalier Universitaire [Strasbourg] Commission Spécialisée Maladies infectieuses et maladies émergentes Assistance Publique - Hôpitaux de Marseille Commission Spécialisée Maladies infectieuses et maladies émergentes Commission Spécialisée Maladies infectieuses et maladies émergentes Département de Médecine Générale ARN régulateurs bactériens et médecine Commission Spécialisée Maladies infectieuses et maladies émergentes Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes] Centre Hospitalier Intercommunal de Cornouaille Commission Spécialisée Maladies infectieuses et maladies émergentes Direction de la Stratégie et des Programmes Commission Spécialisée Maladies infectieuses et maladies émergentes Hôpital Avicenne [AP-HP] Commission Spécialisée Maladies infectieuses et maladies émergentes Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France Haut Conseil de la Santé Publique Commission Spécialisée Maladies infectieuses et maladies émergentes Commission Spécialisée Maladies infectieuses et maladies émergentes Centre International de Recherche en Infectiologie Service des Agents Infectieux et Hygiène [CHU Saint-Etienne] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Commission Spécialisée Maladies infectieuses et maladies émergentes
• Publié dans Eurosurveillance le 28/10/2020

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Résumé : Within the International Health Regulations framework, the French High Council for Public Health was mandated in 2022 by health authorities to establish a list of priority infectious diseases for public health, surveillance and research in mainland and overseas France. Aim Our objective was to establish this list. Methods A multi-criteria decision analysis was used, as recommended by the European Centre for Disease Prevention and Control. A list of 95 entities (infectious diseases or groups of these, including the World Health Organization (WHO)-labelled ‘Disease X’) was established by 17 infectious disease experts. Ten criteria were defined to score entities: incidence rate, case fatality rate, potential for emergence and spread, impact on the individual, on society, on socially vulnerable groups, on the healthcare system, and need for new preventive tools, new curative therapies, and surveillance. Each criterion was assigned a relative weight by 77 multidisciplinary experts. For each entity, 98 physicians from various specialties rated each criterion against the entity, using a four-class Likert-type scale; the ratings were converted into numeric values with a nonlinear scale and respectively weighted to calculate the entity score. Results Fifteen entities were ranked as high-priorities, including Disease X and 14 known pathologies (e.g. haemorrhagic fevers, various respiratory viral infections, arboviral infections, multidrug-resistant bacterial infections, invasive meningococcal and pneumococcal diseases, prion diseases, rabies, and tuberculosis). Conclusion The priority entities agreed with those of the WHO in 2023; almost all were currently covered by the French surveillance and alert system. Repeating this analysis periodically would keep the list updated.

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Fichiers liés : eurosurv-29-50-4.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2024
• Auteurs : Habeeb YusuffPierre-Emmanuel ZornCéline GiraudeauBenoit WachPhilippe ChoquetS. ChatelinJean-Philippe Dillenseger
• Organismes : Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hôpitaux Universitaires de Strasbourg Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hôpitaux Universitaires de Strasbourg Faculté de médecine, maïeutique et sciences de la santé [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hôpitaux Universitaires de Strasbourg Faculté de médecine, maïeutique et sciences de la santé [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg
• Publié dans Magnetic Resonance Materials in Physics, Biology and Medicine le 27/10/2020

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Résumé : Purposes: This research highlights the need for affordable phantoms for MRI education. Current options are either expensive or limited. A phantom, easy to manufacture and distribute, is proposed to demonstrate various pedagogical concepts, aiding students in understanding MRI image quality concepts. Methods: We designed a cylindrical MRI phantom that comprises sections that can be filled with chosen liquids and gels. The dimensions were chosen to fit most consumer-grade 3D printers, facilitating widespread dissemination. It includes five modular sections for evaluating spatial resolution, geometrical accuracy, slice thickness accuracy, homogeneity, and contrast. Results: The modular cylindrical MRI phantom was successfully fabricated. Each section of the phantom was tested to ensure it met the specified pedagogical needs. The spatial resolution section provided clear images for evaluating fine details. The geometrical accuracy section allowed for precise measurement of distortions. The slice thickness accuracy section confirmed the consistency of slice thickness across different MRI sequences. The homogeneity section demonstrated uniform signal distribution, and the contrast section effectively displayed varying contrast levels. Conclusions: This modular MRI phantom offers a cost-effective tool for educational purposes in MRI. Its design enables educators to demonstrate multiple pedagogical scenarios with a single object. The phantom’s compatibility with consumer-grade 3D printers and its modularity makes it accessible and adaptable to various educational settings. Future work could explore further customization and enhancement of the phantom to cover additional educational needs. This tool represents a significant step toward improving MRI education and training by providing a practical, hands-on learning experience.

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Fichiers liés : 2024 Yusuff MRM.pdf

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• Type de publi. :
• Date de publi. : 06/12/2024
• Auteurs : Jose Villasboas BisnetoDanielle WallaceFrancesc BoschCarlos Grande GarciaStephen SmithAntonio PintoReid MerrymanNorma GutierrezJean-Pierre MarolleauLuca ArcainiCristina GarcíaRocío Figueroa MoraBrian TillRosaria de FilippiSara RattottiLucie AubergeonLaurent ChêneJan FagerbergPier Luigi ZinzaniPhilippe ArmandJonathan FriedbergStephen Ansell
• Organismes : Mayo Clinic [Rochester] Wilmot Cancer Institute [Rochester] Vall d'Hebron University Hospital [Barcelona] Universidad de Navarra [Pamplona] Fred Hutchinson Cancer Research Center [Seattle] Istituto Nazionale Tumori IRCCS Fondazione G. Pascale [Naples, Italy] Dana-Farber Cancer Institute [Boston] Instituto de Investigación Biomédica de Salamanca CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Fondazione IRCCS Policlinico San Matteo [Pavia] Vall d'Hebron University Hospital [Barcelona] Universidad de Navarra [Pamplona] Fred Hutchinson Cancer Research Center [Seattle] Istituto Nazionale Tumori IRCCS Fondazione G. Pascale [Naples, Italy] Fondazione IRCCS Policlinico San Matteo [Pavia] Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie] Enterome Enterome Enterome Alma Mater Studiorum Università di Bologna = University of Bologna Dana-Farber Cancer Institute [Boston] University of Rochester Medical Center Mayo Clinic [Rochester]

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Résumé : Background Follicular and marginal zone B cell lymphoma (FL; MZL) demonstrate an indolent course with heterogeneous outcomes and a potential for spontaneous remissions indicating immune system intervention. T cell-based therapeutic approaches are therefore an attractive proposition in FL and MZL. EO2463 peptide immunotherapy expands pre-existing memory CD8 T cells recognizing non-self-protein sequences from gut bacteria which cross-react with B cell antigens. The compound includes 4 HLA-A2 synthetically produced epitopes which exhibit molecular mimicry with the B cell markers CD20, CD22, CD37, and CD268 (BAFF-receptor), as well as a the CD4 helper-epitope UCP2 derived from hTERT. EO2463 is being used to drive anti-tumor immunity against B cell malignancies, and has demonstrated long-lasting, specific CD8-memory T cell responses and clinical activity in relapsed/refractory FL and MZL [J Clinical Oncol 2024, 42 (S16), 7058]. Furthermore, CD8 T cells expanded from samples of patients (pts) treated with EO2463 can kill HLA-A2 expressing lymphoblastoid cell lines presenting the B cell targets [Hematological Oncol 2023, 41 (S2), 581-582]. Methods The current report describes testing of a possible biomarker in the phase 1 portion of the ongoing EONHL1-20/SIDNEY trial (NCT04669171).This part of the trial (“Cohort 1”) included pts (n=9) with relapsed (at least 1, no limit, prior treatments) FL and MZL, stage 1-3A, confirmed to be positive for HLA-A2. Pts received EO2463 (150 [n=3] or 300μg/peptide [n=6]) SC with adjuvant Montanide ISA 51 VG q2 weeks (w) x 4, then q4w, for a max of 12 months; at w7 lenalidomide (20 mg/day for 21/28 days up to 12 cycles) was added (EL), and if no complete remission (CR) at w19, rituximab (375 mg/m IV, q1w x 4, then q4w x 4) was also added (ER2). Immune responses and clinical outcomes of Cohort 1 were previously reported [J Clinical Oncol 2024, 42 (S16), 7058]. To assess a possible biomarker, tetramers were used to specifically detect CD8 T cells recognizing the 4 epitopes in the EO2463 compound (derived from gut bacterial proteins exhibiting molecular mimicry with the B cell markers CD20, CD22, CD37, and CD268). The tetramers were all marked with phycoerythrin. Thawed samples of peripheral blood mononuclear cells taken at start of w5 (after 2 administrations of EO2463 monotherapy, each followed by 2w observation) were stained ex vivo (without any in vitro stimulation) with the tetramers and assayed by flow cytometry. Results are presented as percentage of EO2463 specific CD8 T cells among all CD8 T cells in the peripheral blood of the pt. Results Among the 9 treated pts, PET-CT at w6 (after 3 administrations of EO2463 monotherapy) suggested possible clinical activity in 4/9 pts (1 PR, 1 pt size reduction 15%, 1 pt 20% reduced tracer uptake, 1 pt 5/6 target lesions reduced metabolic activity). By PET-CT at w42 (after 12 administrations of EO2463 monotherapy, 11 cycles of lenalidomide, and rituximab treatment) the Lugano response assessment was complete response in 6/9 pts. A positive biomarker response was assessed in 5/9 pts (percentage of specific CD8 T cells ranged from 0.2-2.1%). EO2463 monotherapy PET-CT activity at w6 (n=4/9 pts): 4 of 4 pts with clinical activity were biomarker positive and 1/5 of the other pts was also positive; this pt had an isolated increase in FDG-uptake at w6, followed by a CR at w19. Four further other pts were biomarker negative. In this limited sample, the biomarker had sensitivity 100% and specificity 80%. EO2463 in combination with lenalidomide/rituximab PET-CT CR at w42 (n=6/9): 5 of 6 pts with CR were biomarker positive and 1 pt with CR was negative; the pt with a negative test had no objective tumor response until after rituximab. In this limited sample, the biomarker showed sensitivity 83% and specificity 100%. Conclusions The current preliminary assessment indicates that direct ex vivo tetramer staining for specific CD8 T cells after short term (5 w) treatment with EO2463 monotherapy could be a possible biomarker for clinical response, both for EO2463 monotherapy response, and for response to EO2463 in combination with lenalidomide/rituximab. We plan to validate these findings in the ongoing study cohorts of the trial; expansion phase 2 cohorts, exploring EO2463 monotherapy in the “watch & wait” setting, EO2463 plus rituximab for 1st line FL/MZL, and EO2463/lenalidomide +/- rituximab in relapsed FL/MZL.

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• Type de publi. : Article dans une revue
• Date de publi. : 06/12/2024
• Auteurs : Jean-Philippe ChippauxYoann MadecPierre AmtaRodrigue NtoneGaelle NoelPedro ClauteauxYap BoumArmand NkwescheuFabien Taieb
• Organismes : Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology Hôpital de Tokombéré [Tokombéré, Cameroon] Epicentre [Paris] [Médecins Sans Frontières] Centre de Recherche Translationnelle - Center for Translational Science Centre de Recherche Translationnelle - Center for Translational Science Institut Pasteur de Bangui Cameroon Society of Epidemiology [Yaounde] Centre Médical de l'Institut Pasteur
• Publié dans Tropical Medicine and Infectious Disease le 25/10/2020

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Résumé : Snakes responsible for bites are rarely identified, resulting in a loss of information about snakebites from venomous species whose venom effects are poorly understood. A prospective clinical study including patients bitten by a snake was conducted in Cameroon between 2019 and 2021 to evaluate the efficacy and tolerability of a marketed polyvalent antivenom. Clinical presentation during the first 3 days of hospitalization was recorded following a standardized protocol. This ancillary study aimed to assess the frequency of bites by the different species encountered in Cameroon and to describe the symptoms of bites by formally identified species. Of the 447 patients included in the study, 159 (35.6%) brought the snake that caused the bite that was identified by a specialist. Out of these, 8 specimens could not be identified due to poor condition, 19 were non-venomous species, and 95 belonged to Echis romani—formerly E. ocellatus—species. The remaining 37 specimens included 2 Atheris squamigera, 12 Atractaspis spp., 2 Bitis arietans, 11 Causus maculatus, 1 Dendroaspis jamesoni, 1 Naja haje, 1 N. katiensis, 5 N. melanoleuca complex, and 2 N. nigricollis. Symptoms, severity of envenomation, and post-treatment course are described. Symptoms and severity of bites are consistent with cases described in the literature, but some specific features are highlighted.

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Fichiers liés : tropicalmed-09-00300-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/12/2024
• Auteurs : Mélisande Bourgoin-HeckVictoria Wolff-GoldnadelYannick ChantranSarah SafTamazoust GuiddirF AmatFanny RancièreIsabelle MomasStéphanie WaninThierry RosePhilippe Saint-PierreJocelyne Just
• Organismes : CHU Trousseau [APHP] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques CHU Trousseau [APHP] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques CHU Trousseau [APHP] CHU Trousseau [APHP] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Université Paris-Saclay Centre de recherche en épidémiologie et santé des populations Hôpital Robert Debré Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques CHU Trousseau [APHP] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Plateforme d'Innovation et de Développement de Tests Diagnostiques / Diagnostic Test Innovation and Development Core Facility Institut de Mathématiques de Toulouse UMR5219 Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
• Publié dans Pediatric Allergy and Immunology le 02/11/2020

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Résumé : Background: Several major sensitization profiles have been described in children with asthma, but it remains unclear how these profiles relate to asthma phenotypes. The aim of this study was to determine allergenic sensitization profiles in a megacity cohort (SAMP). Methods: This was a cross-sectional analysis performed from 2011 to 2015 including preschool and school-age children with severe and moderate asthma from the SAMP cohort. We performed ALEX multiplex array and carried out cluster analysis. Results: Data from 367 children were analyzed: 224 of preschool age and 143 of school age, respectively 84 (38%) and 114 (80%) presented at least one allergic sensitization. At preschool age, three clusters were identified: Cluster 1, Few sensitizations to inhaled allergen molecular families and non-type 2 (T2) inflammation (n = 61); Cluster 2, Predominant sensitization to HDM molecular families (n = 16); Cluster 3, Severe asthma with multiple sensitizations to inhaled and food allergen molecular families (n = 7). At school age, five clusters were identified: Cluster 1, Few sensitizations to inhaled allergen molecular families and non-T2 inflammation (n = 43); Cluster 2, Predominant sensitization to HDM molecular families (n = 31); Cluster 3, Predominant sensitization to PR-10 protein family (n = 25); Cluster 4, Severe asthma with predominant sensitization to tropomyosin family (n = 11); Cluster 5, Severe asthma with multiple sensitizations to inhaled and food allergen molecular families (n = 4). Conclusion: These results underline the heterogeneity of sensitization profiles in severe allergic childhood asthma. The most severe asthma phenotypes were associated with multiple sensitizations to both inhaled and food allergen molecular families as expected, and to the tropomyosin molecular family, a novel finding.

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Fichiers liés : Pediatric Allergy Immunology - 2024 - Bourgoin‐Heck - Molecular allergen sensitization drives phenotypes of severe asthma.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/12/2024
• Auteurs : Driss BerdaïAurélie GuérinDavid PérolCécile GiraultMathieu MolimardPhilippe AmielHélène BeaussierPierre-Henri BertoyeCatherine CornuDominique DeplanqueDidier DreyfussLuc DuchossoyCécile FouretThibaud HaaserAnne Le LouarnSoraya RifaiJean-Pierre Thierry
• Organismes : Bordeaux population health
• Publié dans Therapies le 04/10/2022

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Résumé : In line with the spirit of the Giens workshops, this article reports on the recommended evolution of the Ethics Committees (CPPs) and the Committees for Research Ethics (CER) in France. These committees play a crucial role in the ethical evaluation of clinical research projects, a process that has become more complex, particularly in view of recent legislative, regulatory and methodological developments. This reflection highlights the current challenges faced by the CPPs, including the increasing workload, the complexity of the issues to be addressed and the need for better use of their resources. To address this, several recommendations are proposed. These include improving support to sponsors prior to submission, simplifying administrative tasks for CPP members and improving IT tools. The article also highlights the need for continuous evaluation of the activities of the CPPs to contribute to the quality and consistency of their opinions, as well as the importance of making this activity more attractive to qualified professionals, by offering them adequate compensation and professional recognition. For the benefit of all involved in health research, there is a strong desire to develop a single document management system accessible to all and inclusive of relevant information and document templates. Regarding the CERs, which currently operate without a legal framework, the proposition is that their development should take place under conditions of compliance with essential principles of collegiality, transparency and appropriate management of conflict of interest. Finally, it appeared necessary that the National Commission for Research Involving the Human Person (CNRIPH) be given adequate resources to carry out its tasks effectively, including the coordination of the CPPs and the development of appropriate training programs for their members. These recommendations aim to improve the operating conditions of the CPPs and CERs, ensuring the ethics of the research undertaken, as well as the quality of their results.

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