Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Nathalia da Silva Rodrigues MendesRenato Rodrigues SilvaMoïse Kombolo-NgahPierre-Philippe RivetJerôme TondussonTatianne Ferreira de OliveiraSghaier ChrikiMarie-Pierre Ellies-OuryJean-François Hocquette
• Organismes : Unité Mixte de Recherche sur les Herbivores - UMR 1213 Universidade Federal de Goiás [Goiânia] ISARA Unité Mixte de Recherche sur les Herbivores - UMR 1213 Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Unité Mixte de Recherche sur les Herbivores - UMR 1213 Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine Unité Mixte de Recherche sur les Herbivores - UMR 1213
• Publié dans Veterinary and Animal Science le 29/10/2020

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Résumé : We hypothesized that transportation might impact beef sensory quality, particularly as the distance between farms and the slaughterhouse increases. Specifically, we expected that pre-slaughter transport over longer distances would induce stress in the cattle, resulting in elevated ultimate pH and, consequently, reduced beef quality. Thus, this study aimed to specifically study the effects of transport in commercial conditions of Limousin cows from farms located in different areas of France to slaughter on ultimate pH (pHu) measured in the Longissimus thoracis muscle (LT), marbling (two major factors affecting eating quality) and the MSA Index (a global indicator of potential eating quality at the carcass level). Cattle were studied according to distance (<50 km; between 50 and 150 km; and between 150 and 250 km from the slaughterhouse) and according to transport time from the farm to the slaughterhouse (divided into short, moderate, and extended). We found that neither distance nor transport time significantly affected pHu of beef and the other studied parameters (cold carcass weight, meat color, MSA Marbling and MSA Index). Consequently, in our commercial conditions, we concluded that the effects of transport on beef carcasses and beef eating quality of Limousin cows are negligible.

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Fichiers liés : 2024_ Da Silva Rodrigues Mendes_Vet_Anim_Sci.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Hélène SarterThibaut CrétinGuillaume SavoyeMathurin FumeryAriane LeroyerLuc DauchetThierry PaupardHugues CoevoetPauline WilsNicolas RichardDominique TurckDelphine LeyCorinne Gower-RousseauEric AgouteNajib Al GhossainiRaied Al HameediMyriam Al KhatibSaria Al TurkJean-Marie AndreMatthieu AntoineMichel AntoniettiAmar AouakliLaura Armengol-DebeirIbrahim AroichaneFadi AssiEric AuxenfantsAlina AvramKassem AzzouziDamyan BankovskiBernard BarbryNicolas BardouxPhilippe BaronAnne BaudetPauline BayartBrice BazinArash BebahaniJean-Pierre BecqwortHoussem Ben AliEmmanuel Ben SoussanCoralie BenardVincent BenetCorinne BenguiguiAbdeslam BentalSara Bentaleb-BellatiIsabelle BerkelmansJacques BernetKarine BernouNathalie Bertiaux-VandaelePauline BertotValérie BertrandEmilie BiloudNathalie BironBenjamin BismuthCyril BlanchardMaurice BleuezFabienne BlondelValérie BlondinMarius BobulaPhilippe BohontEléonore BoivinVanessa Bon DjemahEric BonifacePhilippe BonnierePierre BonvarletArnaud BoruchowiczRaoul BostvironnoisMédina BoualitAhlem BouazzaBruno BoucheChristian BoudaillerClaude BourgeauxMorgane Bourgeois-FumeryArnaud BourguetAgnès BourienneHamza BoutalebAlexis BouthorsJulien BrancheFranck BrazierMarie BridenneHélène BrihierLaura BrilPhilippe BuloisPierre BurgiereJoël ButelJean-Yves CanvaValérie Canva-DelcambreFlorence CardotSandrine CarettePierre CarpentierMichel CassagnouJean-François CassarFrançois CastexPascale CatalaStéphane CattanSylviane CatteauBernard CaujolleGérard CayronCatherine ChandelierCloé CharpentierMarthe Chavance-TheluAgathe ChenyDinu ChiritaAntoine ChoteauJean-François ClaerboutPierre-Yves ClergueHugues CoevoetGil CohenMarie ColinRégis ColletJean-Frédéric ColombelStéphanie CoopmanLucie CordiezAntoine CortotJean CorvisartFrédéric CouttenierJean-François CrinquetteValérie CrombeAbdelhakim DaoudiVincent DapvrilThierry DavionSébastien DecosterLaurent DefontaineNicolas DegraveAurélien DejaegerRichard DelcenserieMarine DeleplanqueDorothée DelesalleOlivier DeletteThierry DelgrangeLaurence DelhoustalJean-Stéphane DelmotteSabri DemmaneGuy DeregnaucourtConstance DeschepperJean-Pierre DesechalliersPatrick DesmetPierre DesreumauxGérard DesseauxPhilippe DesurmontAlain DevienneEve DevougeAlex DevrouxArnaud DewaillySébastien DharancyAude Di FioreEmmanuel DiazDjamal DjeddiRachid DjedirWissam DolehMarie-Laure Dreher-DuwatRichard DuboisClothilde DuburqueFrédéric DucrotPhilippe DucrotteAndré DufilhoChristian DuhamelCaroline Dumant-ForestJean-Louis DupasFrédéric DupontYves DurantonArnaud DuriezNicolas DuveauMohammadi El FarisiKhalil El HachkarCaroline ElieMarie-Claire Elie-LegrandMatthieu EocheEssmaeel EssmaeelDominique EvrardJean-Paul EvrardArmelle FatomeKarima Fellah-SekkaiBernard FilocheLaurent FinetMathilde FlahautCamille FlammeDavid FoisseyPeggy FournierPhilippe FoutreinMarie-Christine Foutrein-ComesThierry FrereJulie GalandPhilippe GallaisClaudine GamblinSerge GangaRomain GerardGuillaume GeslinYves GheyssensSalah GhribThierry GilbertBénédicte GilletDenis GodartJean-Michel GodchauxGuetty GoeguebeurOdile GoriaFrédéric GottrandPhilippe GowerLucien GradosBrigitte GrandmaisonMarion GrouxClaire GuedonLoïc GuerbeauMathilde Gueroult-DeroJean-François GuillardLaurence GuillemFrançois GuillemotDominique GuimberBaya HaddoucheVincent HautefeuillePhilippe HecketsweillerGeneviève HecquetJean-Pierre HeddeHassina HellalPierre-Emmanuel HenneresseMichel HeraudSophie HerveBruno HeymanPatrick HochainPhilippe HouckeLucie Houssin-BailllyBruno HugueninSilviu IobagiuShata IstanboliAlexsandar IvanovicIsabelle Iwanicki-CaronEric JanickiMarine JarryCharlotte Jean BartClaude JonasJulia JougonAnne JouvenetNaeim KassarFadi KatherinAlfred KerleveoAli KhachfeAlfred KiriakosJean KiriakosOlivier KleinMatthieu KohutRichard KornhauserDemetrios KoutsomanisJean-Eric LaberenneEric LacotteGuy LaffineurMarine LagardeAnouck LahayeArnaud LalanneAmbroise LalieuPierre LannoyJosé LapchinMichel LaprandDenis LaudeChristian Le CouteulxCharles Le GofficAlain Le GrixJean-Philippe Le MouelPauline Le RoyRachida LeblancPaul LecieuxStéphane LecleireNathalie LeclercJean LedentJean LefebvrePascale LefilliatreCéline LegrandPatrick LelongBernard LeluyerCaroline LemaitreLucie LepileurAntoine LeplatElodie Lepoutre-DujardinGabriel LeppeutHenri LeroiMaryvonne LeroyBenoît LesageJocelyn LesageXavier LesageIsabelle Lescanne-DarchisDominique LescutBruno LeurentDelphine LeyMichel LhermieLouise LibierBernard LisambertIsabelle LogeJulien LoreauAlexandre LouvetJoséphine LozinguezHenri LubrezDamien LucidarmeJean-Jacques LugandOlivier MacaigneDenis MaetzDominique MaillardHubert MancheronOlivia ManolacheAnne-Bérengère Marks-BrunelCharline MarreRaymond MartiEric MarzloffPhilippe MathurinJacques MauillonVincent MaunouryJean-Luc MaupasMichèle-Ange Medam DjomoChloé MelchiorZiad MelkiBenoît MesnardPatrice MetayerLofti MethariFranck MeurisseLaurent MichaudPatricia ModaineAngélique MontheLoïk MorelMathilde MorinPierre-Eugène MortierPerrine MortreuxOlivier MouterdeNicolas MozziconaciJean MudryMaria NachuriMinh Dung NgoEric Nguyen-KhacBertrand NotteghemVincent OllevierAtika OuraghiBarriza OussadouDominique OuvryBernard PaillotClaire PainchartNicole Panien-ClaudotChristian PaolettiArsène PapazianBruno ParentJean-Claude ParisPhilippe PatrierThierry PaupardBernard PauwelsMathieu PauwelsRichard PetitMuriel PiatSandrine PiotteChristophe PlaneBernard PlouvierEric PolletPierre PommeletDaniela PopCharlotte PordesGérard PouchainPhilippe PradesJean-Christophe PrevostManon PruitGilles QuartierAnne-Marie QueunietJean-François QuintonAlain RabacheGilles RaclotSébastien RatajczykNicole ReixThibaud Renaut-VantroysMarine RevillionGhassan RiachiClémentine RiaultNicolas RichardCécile RichezBenoît RimbertPhilippe RobinsonJuan Daniel RodriguezJean RogerJean-Marc RouxAlain RudelliClémence SaingierGuillaume SavoyePatrick SchlossbergDavid SefriouiMichel SegrestinDavid SeguyCélik SeminurFrançois SevenetJean SilvieClaire SpyckerelleNathalie TalbodecNoémie TavernierHenriette TchandeuAurore TechyJean-Luc TheluHenri ThiebaultJean-Marie ThorelChristophe ThuillierGuillaume TielmanManuella TodeJean TonnelJean-Yves TouchaisAudrey Toulemonde-HuguetPierre ToumelinYvan TouzeLéa TranJean-Luc TranvouezNadia TrikiDominique TurckJustine TurpinEric VaillantClaude ValmageDominique VancoNathalie Vandaele-BertiauxHélène VandammeElise Vander EekenEtienne VanderbercqPhilippe VandermollenPhilippe VandevenneLionel VandevilleAlain VandewalleJean-Pierre VanhooveAudrey VanrenterghemCharlotte VanveurenIona VasiesGuy VerbieseJuliette VerlyndePhilippe VermelleChristine VerneGwenola Vernier-MassouillePerrine Vezelier-CocqJuliette ViartBenoît VigneronMarc VincendetJacques ViotY.M. VoimentJean-Yves WallezMichel WantierFaustine WartelJean-Christian WeberJean-Louis WillocquetNathalie WizlaEric WolschiesTajiogue YimforOana ZaharaAlberto ZalarSonia ZaouiAnne Zellweger
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Saint Philibert [Lomme] Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Institute for Translational Research in Inflammation - U 1286 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre Hospitalier de Dunkerque Hôpital privé les Bonnettes [Arras] Institute for Translational Research in Inflammation - U 1286 Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Hôpital universitaire Robert Debré [Reims] Institute for Translational Research in Inflammation - U 1286 Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Institute for Translational Research in Inflammation - U 1286 Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD CHU Amiens-Picardie Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD CHU Amiens-Picardie Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV CHU Amiens-Picardie Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV
• Publié dans The Lancet Regional Health - Europe le 21/04/2021

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Résumé : Background: In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period. Methods: Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time. Findings: A total of 22,879 incident IBD cases were documented (59% (n = 13,445) of Crohn's disease (CD), 38% (n = 8803) of ulcerative colitis (UC), 3% (n = 631) of IBD unclassified (IBDU)). Over the study period, incidence of IBD, CD and UC was 12.7, 7.2 and 5.1 per 105 person-years, respectively. The incidence of CD increased from 5.1/105 in 1988-1990 to 7.9/105 in 2015-2017 (annual percent change (APC): +1.9%, p < 0.0001). The incidence of UC increased from 4.5/105 to 6.1/105 (APC: +1.3%, p < 0.0001). The largest increase was observed in children (+4.3% in CD, p < 0.0001; +5.4% in UC, p < 0.0001) followed by young adults aged 17-39 years (+1.9% in CD, p < 0.0001; +1.5% in UC, p < 0.0001). The increase in UC incidence was significantly higher in women than in men (+1.9% in women, +0.8% in men; p = 0.006). We estimated that in our area, by 2030, nearly 0.6% of the population will have IBD. Interpretation: The persistent increase of IBD incidence among children and young adults but also in women with UC in Northern France, suggests the persistence of substantial predisposing environmental factors.

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Fichiers liés : EPIMAD LANCET REG HEALTH 2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Mathilde AmiotLaurent MortierStéphane DalleOlivier DereureSophie DalacCaroline DutriauxMarie-Thérèse LecciaEve MaubecJean-Philippe ArnaultFlorence Brunet-PossentiJulie de QuatrebarbesFlorence Granel-BrocardCaroline Gaudy-MarquesteCecile PagesPierre-Emmanuel StoebnerPhilippe SaiagThierry LesimpleDelphine LegoupilAlain DupuyHenri MontaudiéBastien OrianoCeleste LebbeRaphaël Porcher
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Methods of therapeutic evaluation of chronic diseases | Méthodes de l’évaluation thérapeutique des maladies chroniques Centre d'épidémiologie Clinique [Hôtel-Dieu]
• Publié dans EClinicalMedicine le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Maxime de GuillebonRodrigue GarciaStéphane DebeugnyHugues BaderVincent ProbstNicolas BidegainKumar NarayananJacques MansouratiAymeric MenetPierre OllitraultChristelle MarquiéBenoît Guy-MoyatPierre MondolyPhilippe ChevalierNicolas BadencoNathalie BeharLaurence Jesel-MorelBertrand PierreNicolas LelloucheJean-Claude DeharoPeggy JaconFrédéric AnselmeSerge BovedaEloi Marijon
• Organismes : Centre hospitalier de Pau Service de cardiologie [CHU de Poitiers] CIC Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre hospitalier de Pau Centre hospitalier de Pau Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Européen Georges Pompidou [APHP] Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques Université catholique de Lille Hôpital Saint Philibert [Lomme] Université de Caen Normandie - UFR Santé Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Université de Limoges CHU Limoges Service Cardiologie [CHU Toulouse] Hôpital Louis Pradel [CHU - HCL] Université Claude Bernard Lyon 1 CHU Pitié-Salpêtrière [AP-HP] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nanomédecine Régénérative Centre de Recherche en Biomédecine de Strasbourg Nouvel Hôpital Civil de Strasbourg CHU Trousseau [Tours] CHU Henri Mondor [Créteil] Hôpital de la Timone [CHU - APHM] Aix Marseille Université Centre Hospitalier Alpes Isère [Grenoble, France] CHU Rouen Clinique Pasteur [Toulouse] Hôpital Européen Georges Pompidou [APHP]
• Publié dans Heart Rhythm le 26/10/2020

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Résumé : Background: Electrocardiographic screening before subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation is unsuccessful in around 10% of cases. A personalized screening method, by slightly moving the electrodes, to obtain a better R/T ratio has been described to overcome traditional screening failure. Objective: The objectives of the SIS study were to assess to what extent a personalized screening method improves eligibility for S-ICD implantation and to evaluate the inappropriate shock rate after such screening success. Methods: All consecutive patients eligible for an S-ICD implantation were prospectively recruited across 20 French centers between December 2019 and January 2022. In case of traditional screening failure, patients received a second personalized screening. If at least 1 vector was positive, the personalized screening was considered successful, and the patient was eligible for implantation. Results: The study included 474 patients (mean age, 50.4 ± 14.1 years; 77.4% men). Traditional screening was successful in 456 (96.2%) cases. This figure rose to 98.3% (n = 466; P = .002) when personalized screening was performed. All patients implanted after successful personalized screening had correct signal detection on initial device interrogation. Nevertheless, after 1-year follow-up, 3 of the 7 patients (43%) implanted with personalized screening experienced inappropriate shock vs 18 of the 427 patients (4.2%) with traditional screening and S-ICD implantation (P = .003). Conclusion: Traditional S-ICD screening was successful in our study in a high proportion of patients. Considering the small improvement in success of screening and a higher rate of inappropriate shock, a strategy of personalized screening cannot be routinely recommended. Clinicaltrials: gov identifier: NCT04101253

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Fichiers liés : de Guillebon et al. - 2024 - Personalized Screening Before Subcutaneous Cardiov.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Renaud TamisierCarole PhilippeArnaud PrigentChristelle Charley-MonacaMarie-Pia d’OrthoThibaut GentinaF. GagnadouxClaire LaunoisVanessa BironneauJean Pierre MalletToufik DidiTiphaine GuyFrédéric GoutorbeChristophe PerrinSandrine Pontier-MarchandiseJean-François TimsitJean-Louis PépinJean-Claude MeuriceFaiza BettayebChristelle Charley MonacaAri ChaouatAla CovaliToufik DidiPierre EscourrouFrédéric GagnadouxThibaud GentinaFrédéric GoutorbeTiphaine GuyCarmen IamandiRomain KesslerHauria KhemlicheChristian KoltesClaire LaunoisSandrine LaunoisVirginie LevratLionel LerousseauJean-Pierre MalletFrancis MartinJean-Claude MeuriceMarie-Pia d'OrthoAudrey ParisCarole PhilippeJean-Louis PépinChristophe PerrinCarole PhilippeSandrine PontierArnaud PrigentClaudio RabecFrédéric RocheMaria Stoica PotoceanuRenaud TamisierAnne Thibault-StollJean Claude MeuriceChristelle Charley MonacaJean-Marc DavyThibaud DamyRenaud TamisierPierre EscourrouFrédéric GagnadouxJean-Louis PépinThibaud GentinaEric HazouartDany JaffuelChristophe PerrinCarole PhilippeArnaud PrigentStefania RedolfiIsabelle Durand ZaleskiJean-François Timsit
• Organismes : Université Grenoble Alpes - UFR Médecine Hypoxie et PhysioPathologie Centre Hospitalier Universitaire [CHU Grenoble] Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 Service des maladies respiratoires et allergiques [CHU Reims] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire Mécanismes d'Accidents Université Gustave Eiffel Département Mécanismes d'Accidents Institut National de Recherche sur les Transports et leur Sécurité Unité de recherche Mécanismes d'accidents Laboratoire Mécanismes d'Accidents Département Transport, Santé, Sécurité Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 Service des maladies respiratoires et allergiques [CHU Reims]
• Publié dans Chest le 29/10/2020

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Résumé : Background A large number of symptomatic individuals with central sleep apnea (CSA) in clinical practice have an indication for adaptive servo-ventilation (ASV) therapy. Research Question What are the effects of ASV therapy on sleep quality and PROMs in patients with CSA across a range of devices and indications. Methods This prospective, multicenter, observational cohort study was conducted in France and enrolled participants from June 2017 to February 2020. Adults with predominant CSA at diagnosis or obstructive sleep apnea with central events not controlled with continuous positive airway pressure who had an indication for ASV were eligible. Participants attended clinic visits at baseline, and after 1, 3, 6 and 12 months of follow-up. The primary endpoint was the change in Pittsburgh Sleep Quality Index (PSQI) score from baseline to 6-month follow-up (evaluated using a Wilcoxon signed rank test on paired data). Results We included 526 individuals (median age 69 years, 88.2% male). The indication for ASV included CSA with cardiovascular/neurologic etiology (38.4%), treatment-emergent CSA (36.1%), idiopathic CSA (14.1%) or drug-induced CSA (11.4%). At 6-month follow-up, study participants were using ASV for a median of 6.1 h/night. The median [interquartile range] change in the PSQI score from baseline to 6 months in the overall study population was –1 [–3; 0] (p<0.001), with significant results across all indications for ASV except for drug-induced CSA, where the median change was similar to the overall result but did not achieve statistical significance (–1 [–2; 1]; p=0.0866). Overall, 65% of participants had a ≥1-point improvement in the PSQI. Interpretation Individuals with a clinical indication for ASV therapy experienced improved sleep quality during real-world treatment, irrespective of which ASV device was used.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Léa PaoliniThi TranStéphanie CorgnacJean-Philippe VilleminMarie WislezJennifer ArrondeauLudger JohannesJonathan UlmerLouis-Victorien VieillardJoséphine PineauAlain GeyValentin QuiniouPierre BarennesHang Phuong PhamNadège GruelMilena HasanValentina LibriSebastien MellaSixtine de PercinPascaline Boudou-RouquetteAziza CaidiIsabelle CremerHélène BlonsKaren LeroyPierre Laurent-PuigHortense de Saint BasileLaure GibaultPatrice RavelFathia Mami-ChouaibFrançois GoldwasserElizabeth FabreDiane DamotteÉric Tartour
• Organismes : Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Immunologie intégrative des tumeurs et immunothérapie des cancers Institut de Recherche en Cancérologie de Montpellier Centre de Recherche des Cordeliers Hôpital Cochin [AP-HP] Institut Curie [Paris] Institut Curie [Paris] Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Hôpital Necker - Enfants Malades [AP-HP] Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Hôpital Necker - Enfants Malades [AP-HP] Parean biotechnologies Parean biotechnologies Parean biotechnologies Cancer, Hétérogénéité, Instabilité et Plasticité (U830) Université Paris Sciences et Lettres Cytometrie et Biomarqueurs – Cytometry and Biomarkers Cytometrie et Biomarqueurs – Cytometry and Biomarkers Cytometrie et Biomarqueurs – Cytometry and Biomarkers Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Immunologie intégrative des tumeurs et immunothérapie des cancers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Cancer Research and Personalized Medicine - CARPEM [Paris] Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Institut de Recherche en Cancérologie de Montpellier Immunologie intégrative des tumeurs et immunothérapie des cancers Hôpital Cochin [AP-HP] Paris-Centre de Recherche Cardiovasculaire Centre de Recherche des Cordeliers Hôpital Cochin [AP-HP] Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP]
• Publié dans Journal for Immunotherapy of Cancer le 24/10/2020

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Résumé : Background A high density of resident memory T cells (TRM) in tumors correlates with improved clinical outcomes in immunotherapy-treated patients. In most clinical studies, TRM are defined by the CD103 marker. However, it is clearly established that not all TRM express CD103, but can be defined by other markers (CD49a, CD69, etc). The frequency of these subpopulations of TRM expressing or not CD103 varies according to the location of the cancer. Little is known about their functionality and their predictive impact on response to immunotherapy. In preclinical models, only some subpopulations of TRM are associated with cancer vaccine efficacy. Methods Multiparametric cytometry analyses were used to demonstrate the presence of TRM subpopulations in the lung in mice after vaccination and in fresh ex vivo human non-small cell lung cancer (NSCLC). An analysis of the T-cell repertoire of these TRM was conducted to search for their relationships. Multiplex immunofluorescence techniques were used to quantify intratumor infiltration of TRM subpopulations in two cohorts of patients with NSCLC. The impact on the clinical outcome of the TRM tumor infiltration was also investigated. Results We identified two main TRM subpopulations in tumor-infiltrating lymphocytes derived from patients with NSCLC: one co-expressing CD103 and CD49a (double positive (DP)), and the other expressing only CD49a (simple positive (SP)); both exhibiting additional TRM surface markers like CD69. Despite higher expression of inhibitory receptors, DP TRM exhibited greater functionality compared with SP TRM. Analysis of T-cell receptor (TCR) repertoire and expression of the stemness marker TCF1 revealed shared TCRs between populations, with the SP subset appearing more progenitor-like phenotype. In the training cohort, PD-L1 (Programmed Death-Ligand 1) and TCF1+CD8+T cells predict response to anti-PD-1. In patient with NSCLC validation cohorts, only DP TRM predicted PD-1 blockade response. Multivariate analysis, including various biomarkers associated with responses to anti-PD-(L)1, such as total CD8, TCF1+CD8+T cells, and PD-L1, showed that only intratumoral infiltration by DP TRM remained significant. Conclusions This study highlights the non-equivalence of TRM subpopulations. The population of TRM co-expressing CD103 and CD49a appears to be the most functional and has the most significant capacity for predicting response to immunotherapy in multivariate analysis in patients with NSCLC.

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Fichiers liés : jitc-12-12.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Gustave MabiamaDieudonné AdiogoJean-Claude DesportPhilippe FayemendyPierre JésusPierre-Marie Preux
• Organismes : Université de Douala Epidémiologie des Maladies Chroniques en zone tropicale Microbiology, Immunology-Hematology and Morphologic Sciences Laboratory (LMIHSM) Microbiology, Immunology-Hematology and Morphologic Sciences Laboratory (LMIHSM) Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Aging and Health Research le 22/11/2024

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Résumé : Background: Depressive syndrome (DS) and cognitive impairment (CI) are associated with unsuccessful aging. However, little is known about Cameroon. This study aimed to assess the factors associated with DS and CI among older adults in Cameroon. Methods: A representative sample of 599 individuals aged ≥ 60 years was selected for this cross-sectional study. Sociodemographic and health data were also collected. DS and CI were assessed using the Center for Epidemiologic Studies-Depression Scale (CES-D) and Mini-Mental State Examination (MMSE), respectively. The Rosow Mobility Scale, Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) scales were used to evaluate functional abilities. Chi-2, ANOVA, and multiple regression analyses were performed to assess the factors associated with DS and CI. The threshold of statistical significance was 5 %. Results: The average age was 68.9 ± 7.2 years, sex ratio M/F = 0.93, and weight 68.5 ± 14.7 kg. DS affected 14.5 % of the population and the CI was 21.4 %. In the multivariate analysis, DS was positively associated with male gender (Odds Ratio (OR) = 1.7 [95 % Confidence Interval (CI):1.1-2.7], p = 0.031) and inactivity (OR = 1.7 [95 % CI:1.0-3.0], p = 0.043). CI was positively associated with lack of education (OR = 6.5 [95 % CI:3.5-12.2], p < 0.001), inactivity (OR = 5.3 [95 % CI:1.6-17.9], p = 0.008), single (OR = 3.7 [95 % CI:1.2-11.3], p = 0.023), and widowhood (OR = 3.3 [95 % CI:1.6-6.5], p = 0.001), and negatively associated with no IADL (OR = 0.3 [95 % CI:0.2-0.6], p = 0.001) and ADL disability (OR = 0.5 [95 % CI:0.2-0.9], p = 0.032) limitations. Conclusions: The associated factors suggest that it might be of interest to fight inactivity and encourage early and long-term education to prevent DS and/or CI among older adults.

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Fichiers liés : 1-s2.0-S2667032124000301-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Estelle NeyrinckBaptiste RoussetCécile DoubreLuis RiveraCécile LasserreMarie-Pierre DoinPhilippe DurandRoger BilhamZiyadin Çakir
• Organismes : Institut Terre Environnement Strasbourg Institut Terre Environnement Strasbourg Institut Terre Environnement Strasbourg Institut Terre Environnement Strasbourg Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Institut des Sciences de la Terre Centre National d'Études Spatiales [Toulouse] University of Colorado [Boulder] Istanbul Technical University
• Publié dans Earth and Planetary Science Letters le 01/11/2020

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Fichiers liés : 1-s2.0-S0012821X24005363-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Guillermo A AlanisPierre BoutouyrieMouad AbouqatebRosa Maria BrunoRachel E ClimieThomas van SlotenNicolas DanchinBruno PannierStéphane LaurentXavier JouvenJean‐philippe Empana
• Organismes : Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire University of Tasmania [Hobart] Paris-Centre de Recherche Cardiovasculaire University Medical Center [Utrecht] Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire University of Tasmania [Hobart]
• Publié dans American Journal of Preventive Cardiology le 09/04/2025

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Résumé : Objective: To investigate the association between joint manifestations of vascular ageing (VA) and hypertension. Methods: We used baseline (2008-2012) and follow-up data (up to 2024) from the Paris Prospective Study III, a French cohort of 10,157 participants. Prevalent and incident hypertension were determined at baseline (blood pressure ≥140/90 mmHg or on medication) and at 2, 4, 6, 8 and 10 years of follow-up (self-reported antihypertensive treatment). VA manifestations were assessed at baseline via echo-tracking in the right common carotid artery. Clustering analysis identified patterns of VA and their association with hypertension was assessed with logistic regression. Results: The cross-sectional analysis included 9,096 participants (mean age: 59±6 years, 39% female). Hypertension prevalence was 36% (n=3,276). Three clusters of VA manifestations were identified. Cluster 1 (n=4,326;47.6%) was characterized by healthy vascular ageing (HVA), Cluster 2 by increased arteriosclerosis (ART) (n=2,274;25.0%) and Cluster 3 by greater atherosclerosis prevalence (ATH) (n=2,496;27.4%). Compared to the HVA cluster, ART (aOR 3.94; 95% CI 3.50;4.45) and ATH clusters (aOR 2.69; 95% CI 2.38;3.04) were associated with prevalent hypertension. The prospective analysis included 5,310 normotensives with 754 (14.1%) cases of incident hypertension (median follow-up of 10.05 years [range: 10.00;10.15]). Both ART (aOR 1.34; 95% CI 1.08;1.65) and ATH (aOR 1.70; 95% CI 1.40;2.07) clusters were associated with incident hypertension. Conclusion: Vascular ageing manifestations reflecting increased carotid arteriosclerosis and atherosclerosis are related to prevalent and incident hypertension.

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Fichiers liés : AJPC Alanis et al - Hypertension paper.pdf

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• Type de publi. : Autre publication
• Date de publi. : 01/12/2024
• Auteurs : Fabien ChardonPhilippe GuercheSophie Jasinski
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : Objective The primary aim of this collection is to identify the main genetic and physiological factors that guide the accumulation of reserves, particularly in the form of lipids or proteins, in Arabidopsis thaliana. Arabidopsis serves as a valuable model for understanding reserve accumulation in European oilseeds. This dataset collection can also be used to explore the genetic and physiological factors guiding seed composition in Arabidopsis, with potential applications in comparative genetics, environmental response studies, and functional genomics. Archive 1 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration, all estimated using NIRS. Additional Traits: Plant Flowering Time, Thousand Seed Weight. Populations Studied: 20 recombinant inbred lines (RILs) from four populations: Bla-1×Col-0, Tsu-0×Col-0, Ct-1×Col-0, and Cvi-0×Col-0. Natural Accessions: Includes 49 natural accessions of Arabidopsis thaliana. Replicates: Data collected in three replicates per line or accession. Growth Conditions: Plants were grown in growth chamber. Archive 2 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Additional Traits: Plant Flowering Time, Thousand Seed Weight. Populations Studied: 20 recombinant inbred lines from eight populations: Bla-1×Col-0, Tsu-0×Col-0, Ct-1×Col-0, Cvi-0×Col-0, Shahdara×Col-0, Ge-0×Col-0, Bur-0×Col-0, and Blh-1×Col-0. Natural Accessions: Includes 49 natural accessions of Arabidopsis thaliana. Replicates: Data collected in three replicates per line or accession. Growth Conditions: Plants were grown in growth chamber. Archive 4 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Additional Traits: Plant Flowering Time, Thousand Seed Weight. Populations Studied: 20 recombinant inbred lines from eight populations (same as Archive 2). Natural Accessions: 49 natural accessions, plus 2 mutants (pkp2-1, tag1-2, wri1-3). Replicates: Data collected in three replicates per line or accession. Growth Conditions: Plants were grown in growth chamber. Archive 5 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Additional Traits: Thousand Seed Weight. Populations Studied: Around 160 inbred lines from three recombinant inbred line populations: Ct-1×Col-0, Cvi-0×Col-0, and Bur-0×Col-0. Replicates: Data collected in three replicates per line. Growth Conditions: Plants were grown in greenhouses. Reference: Data corresponds to the material used in the study by Chardon et al. (2014). Archive 6 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Populations Studied: 324 natural Swedish accessions of Arabidopsis thaliana. Replicates: Data collected in four replicates per accession. Growth Conditions: Plants were grown in growth chambers.

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