Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Jean FurstossCarlos SalazarPhilippe CarrezPierre HirelJulien Lam
• Organismes : Centre de Mise en Forme des Matériaux Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207
• Publié dans Computer Physics Communications le 30/10/2020

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Résumé : To accurately identify local structures in atomic-scale simulations of complex materials is crucial for the study of numerous physical phenomena including dynamic plasticity, crystal nucleation and glass formation. In this work, we propose a data-driven method to characterize local atomic environments, and assign them to crystal phases or lattice defects. After constructing a reference database, our approach uses descriptors based on Steinhardt's parameters and a Gaussian mixture model to identify the most probable environment. This approach is validated against several test cases: polymorph identification in alumina, and dislocation and grain boundary analysis in the olivine structure.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Baptiste BidonHajar YaakoubA. LanoueAntoine GéryVirginie SeguinFlorent MagotClaire HoffmannVincent CourdavaultJean-Philippe BoucharaJean-Pierre GangneuxJens C. FrisvadAntonis RokasGustavo GoldmanGilles NevezSolène Le GalDomenico DavolosDavid GaronNicolas Papon
• Organismes : National Taiwan University Service Commun d'Imagerie et d'Analyse Microscopique [SFR ICAT - UA] Physiopathologie des Adaptations Nutritionnelles Biomolécules et Biotechnologies Végétales Aliments Bioprocédés Toxicologie Environnements Aliments Bioprocédés Toxicologie Environnements Biomolécules et Biotechnologies Végétales Hôpital de la Cavale Blanche - CHRU Brest Centre Hospitalier Régional Universitaire de Brest Biomolécules et Biotechnologies Végétales Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire [Rennes] Institut de recherche en santé, environnement et travail Danmarks Tekniske Universitet = Technical University of Denmark Vanderbilt University [Nashville] Universidade de São Paulo = University of São Paulo SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] Aliments Bioprocédés Toxicologie Environnements Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques
• Publié dans Genome Biology and Evolution le 01/11/2020

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Résumé : Like bacteria and plants, fungi produce a remarkable diversity of small molecules with potent activities for human health known as natural products or secondary metabolites. One such example is mycophenolic acid, a powerful immunosuppressant drug that is administered daily to millions of transplant recipients worldwide. Production of mycophenolic acid is restricted to a very limited number of filamentous fungi, and little is known about its biosynthetic modalities. It is therefore a particular challenge to improve our knowledge of the biosynthesis of this valuable natural compound, as this would contribute to a better understanding of the specialized metabolism of fungi and could also lead to the identification of new fungal producers for the supply of immunosuppressants. Here, we were interested in deciphering the origin and evolution of the fungal mycophenolic acid biosynthetic pathway. Large-scale analyses of fungal genomic resources led us to identify several new species that harbor a gene cluster for mycophenolic acid biosynthesis. Phylogenomic analysis suggests that the mycophenolic acid biosynthetic gene cluster originated early in a common ancestor of the fungal family Aspergillaceae but was repeatedly lost and it is now present in a narrow but diverse set of filamentous fungi. Moreover, a comparison of the inosine 5′-monophosphate dehydrogenase protein sequences that are the target of the mycophenolic acid drug as well as analysis of mycophenolic acid production and susceptibility suggest that all mycophenolic acid fungal producers are resistant to this toxic compound, but that this resistance is likely to be based on different molecular mechanisms. Our study provides new insight into the evolution of the biosynthesis of the important secondary metabolite mycophenolic acid in fungi.

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Fichiers liés : evaf039.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Guillemette UnalRémonie SengElodie Alessandri-GradtLorraine PlessisMathilde GhislainCécile GoujardMarie LeozJean-Christophe PlantierLaurence MeyerClaudine DuvivierFatima TouamGilles PialouxSophie Le NagatLaurence SlamaJulie ChasThomas L'YavancJacqueline CapeauCorinne VigourouxSoraya FellahiJean-Philippe BastardJean-Paul ViardAline MaignanAgnès CrosAlain SobelLaurence GérardDaniel SéréniLe van DienJean-Michel MolinaCaroline Lascoux-CombeAlexandre AslanSuna BalkanNathalie Colin de VerdièreNathalie de CastroJeanine DelgadoSylvie ParlierClaire PintadoDiane PonscarmeWilly RozenbaumOlivier TauleraSébastien GallienValérie GarraitCaroline GateySandrine GazaignesJérôme GoguelMatthieu LafaurieAnne-Lise MunierJean-François BergmannAgathe RamiMaguy ParrinelloPierre-Marie GirardJulie BotteroZineb OuazeneBénédicte LefebvreNadia VacinPauline CampaDiane BoccensSerge HersonHassiba RemidiMalik IguertsiraSmaïl NafissaCatherine LupinAnne SimonNadia EdebDominique Salmon-CéronLoïc GuillevinTassadit TahiMarie Pierre PietriLaurence WeissJuliette PavieMarina KarmochkineDominique BatisseMartin BuissonJean DerouineauMaria ManeaMarie-Laure LucasMatheron SophieGolriz PahlavanEmmanuelle PaputFrançoise LouniStanislas HarentSylvie LegalGuylaine CastorPhung BaoIsabelle FournierRalaimazava Pascal Julia ZelieCindy GodardFrançois BouéValérie MartinezElsa MiekoutimaMarion FavierCarole PignonVéronique ChambrinImad KansauFior RenatoMariem Raho-MoussaBruno FantinAgnès UludagAli TadlaouiCaroline PoderValentin Iwaka BamaeSihasi MakloufiPatricia HonoréOlivier BouchaudSophie AberallCécile GoujardYann QuertainmontRaluca SterpuFrédéric FourreauDelphine PerettiTaylor Pindi SalaK. BourdicYves LévyJean-Daniel LelièvreStéphanie DominguezGiovanna MelicaCarine BelzunceMaryline SaidaniAnne-Sophie LascauxJose Luis Lopez ZaragozaCécile DumontAndré CabiéSylvie AbelPatrick HochedezFrançois RoninAnne-Sophie BatallaChristophe CerlandIsabelle Poizot-MartinAnne-Suzel RitlengMeriem GuignardNicolas CroarecCarle Blanco BétancourtOlivia Zaegel-FaucherAlena IvanovaMarie-Josèphe CarmantrandSaadia MokhtariMarie-Christine Thiebaut-DrobacheffAdeline Foltzer Cécile Haffner-MauvaisFrançois ParcelierQuentin GardiennetCatherine ChireuzeJean-François FaucherLaurent Hustache-MathieuGabriella IllesDidier NeauCharles CazanaveThierry PistoneMichel DuponFrédéric DauchyHervé DutroncIsabelle Raymond-LetronLaetitia Lacaze-BuzyPhilippe MorlatFrançois PaccalinSabrina CaldatoJulien Roger-SchmeltzMarie-Carmen PertusaMarie-Catherine ReceveurCédric MartellDenis LacostePierre DuffauMojgan HessamfarJacques ReynesClaude CrisolVincent BaillatVincent Le MoingJean-Marc JacquetMarie-Laure CasanovaAlain MakinsonAntoine VilladoroCarine FavierCristina PsomasCorinne Merle de BoeverChristine TramoniLouis BernardPascale NauGaëlle SajoleCarine SèvreAntoine SouffletPatrick GuadagninFrédéric BastidesPatrick ChoutetFrançois RaffiClothilde AnavenaMartine ColasLaurence LarmetPascale Morineau Le HoussincCécile Brunet-CartierVéronique ReliquetPatrick PointOlivier AubryHervé HueThierry MayMarie-Pierre BouillonMickaël DelestanMarie AndréAntoine ChéretFaiza AjanaIsabelle AlcarazVéronique BacletRaphaël BiekreHugues MelliezMichel ValetteNathalie VigetThomas HuleuxEmmanuelle AïssiDavid ReyMarialuisa PartisaniChristine CheneauMichèle PriesterMarie-Laure BatardMahsa Mohseni ZadehAurélie RichardThomas GilleMartin MartinotAnne PachardDjamila MakhloufiJean-Michel LivrozetPierre ChiarelloFlorence Brunel-DalmasFlorence GarnierChristian ChidiacClaude Augustin-NormandJoseph KoffiPatrick MiailhesSophie PailhesIsabelle SchliengerThomas PerpointAndré BoibieuxCorinne BrochierPhilippe PerréOlivia Bolengia StragiaThomas GuimantSophie Leautez NainvilleJean Luc EsnaultLaetitia LaineNadine RabilleCatherine AlbrechtHélène DurandIsabelle SuaudJ ChennebaultP FialaireHélène Le Guillou-GuillemetteS RehaiemB ChanzyG ClavereJ GaillatL CourdavaultPhilippe GenetJ GerbeC BenoitS Honore BouaklineA WaldnerD BettingerC ChirouzeN BernardS ReigadasX DupontJ L GaillardElyanne GaultE ReimannG OtterbeinL ThomasP VaghefiM BenoitN ButhiotA GouxV ChambrinClaire DebackRita FiorM Raho MoussaO AntoniottiD CobanL CormeraisCécile HenquellChristine JacometOlivier LesensN ChanoineA VillmantJ L van AutreveM BlochH IchouV ManceronE MortierA ZengMagali Bouvier-AliasS DominguezA S Lascaux-CametezJ D LelievreY LevyG Melica-GregoireJean-Michel PawlotskyP PothierA WaldnerL InchiappaA VerhaegheB OlivierJ P PatheH BertheD MathezV FavretD TroisvalletsE VandemeulebrouckeJ CeccaldiZ El HarifL BocketP BarbutF ChaixCéline LambertT LambolezJ MiatezilaO SonPascal BrunetC ChappeC DhiverV LecomteLine MeddebIsabelle Poizot-MartinC TamaletJ ValadierG Beck-WirthM BenomarJ M DelarbreJ M PeterS BevilacquaV VenardV DaneluzziN IdriB MontoyaValentine Marie FerréE GarnierH HueL LarmetP PointF RaffiV ReliqietA RodallecS SecherP AmoyelE BottonM JanowskiY Le CocguicP DeleplanqueJ M DescampsM LapineS SunderM ChansombatC CharpentierF DamondB DialloX DuvalZ JuliaR LandmanS LegacC RiouxP YeniA KrivinePaul BlancheA CrosP GazaletJade GhosnA KrivineA SobelBéatrice BerçotM DiemerM ParrinelloC Bey BoumezragL BodardS GibertF X HucheL RaffenneM StreblerCaroline BlancE BourzamBoris HanselC LupinMarc WirdenE BourzamL ColliasJ EffaC JungJ PavieHélène PéréA Si MohamedC. DelaugerreL GerardB LozeS. MaylinR NabiasD PonscarmeJean‐françois DeleuzeF RozenbergB BachourFirouzé Bani-SadrJ ChasM HamidiL KherallahS Le NagatC Le PendevenF MoreauJ C NicolasV SchneiderM D TaboneG VaudreG GiraudeauGwénaël Le MoalD PlainchampG BlondinI DorvalJ C DutheP PerfezouJ L BergerV BrodardI KmiecC RougerC StradyJ M ChappelinA MaillardM RatajczakY DebabF de OliveiraA DepatureauxI GueitV LemeeD TheronI PasdeloupP CampsC BigaillonC FickoC ImbertC RappC GrandC MichauD BornarelP DevillierE FarfourC MajerholcD VignonD ZucmanM El AddouliM F DanjouxJ JourneY LeveneurB. MarchouF NicotF Prevoteau Du ClaryS Bonne
• Organismes : Institut National de la Santé et de la Recherche Médicale Université de Rouen Normandie Université de Caen Normandie Normandie Université Institut National de la Santé et de la Recherche Médicale Centre de recherche en épidémiologie et santé des populations Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Université de Rouen Normandie Université de Caen Normandie Normandie Université Institut National de la Santé et de la Recherche Médicale Centre de recherche en épidémiologie et santé des populations Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Centre de recherche en épidémiologie et santé des populations Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Centre de recherche en épidémiologie et santé des populations Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Université de Rouen Normandie Université de Caen Normandie Normandie Université Institut National de la Santé et de la Recherche Médicale Université de Rouen Normandie Université de Caen Normandie Normandie Université Institut National de la Santé et de la Recherche Médicale Centre de recherche en épidémiologie et santé des populations Université Paris-Saclay
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Background Therapeutic outcomes for patients infected by genetically divergent HIV-1/O are not well-known due to scarce data and the lack of an appropriate comparison with patients infected by pandemic HIV-1/M. We aimed to compare the immunological and virological response to cART between HIV-1/O and HIV-1/M patients followed in France. Methods All naïve HIV-1/O subjects initiating cART in France in ANRS-ORIVAO study were compared to naïve HIV-1/M subjects initiating cART in ANRS-COPANA cohort. Piecewise linear mixed-effect models and Kaplan–Meier survival curves were used to analyse immunological and virological response to cART overall (65 HIV-1/O versus 279 HIV-1/M), then only in patients initiating 2INTI + 1PI/r. Results Plasma viral load (pVL) at treatment initiation was 0.6 log10 copies/mL lower in HIV-1/O than in HIV-1/M patients (P = 0.004) in the overall population, but there was no difference in the time to pVL < 200 cp/mL after cART initiation (log rank test, P = 0.57). Meanwhile, baseline CD4 counts were lower in HIV-1/O (median 180/mm3) than HIV-1/M (248/mm3) patients (P = 0.001). At 4 months, the increase in CD4 counts did not differ (P = 0.96) between groups but remained lower in HIV-1/O patients beyond 4 months of treatment (P = 0.04). In PI/r population, baseline pVL was 1 log10 copies/mL lower for HIV-1/O than HIV-1/M patients, leading to significantly faster attainment of pVL < 200 cp/mL (log rank test: P < 0.001); immunological response to cART was similar. Conclusions HIV-1/O and HIV-1/M immunological and virological responses to cART did not differ when epidemiological characteristics of the patients were taken into account. In France, treating HIV-1/O following HIV-1/M guidelines leads to similar therapeutic outcomes.

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• Type de publi. : Rapport
• Date de publi. : 01/01/2025
• Auteurs : Julien RouzotChristian ArtiguesPhilippe GarnierEmmanuel HebrardPierre LopezAdrien MaillardG Rabideau
• Organismes : Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Institut de recherche en astrophysique et planétologie Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Jet Propulsion Laboratory Jet Propulsion Laboratory

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Résumé : In deep space missions, scientific data generated by onboard instruments must be temporarily stored in local memory buffers before being downlinked to Earth during limited communication windows. Efficient scheduling of these data transfers is essential to prevent buffer overflows and data loss, particularly in the presence of uncertainties. Previous work has considered the overlapping Memory Dumping Problem (oMDP), which consists in assigning transfer priorities to the memory buffers and minimize the peaks memory usage, which reduces the risk of overflow. In this paper, we consider additional decisions in the transfer plans that are implementable in practice: data transfer from each buffer can be interrupted after a given time, once per downlink window, preventing it from dumping data until the next window, but redistributing the unused bandwidth to the other buffers. The new problem is called oMDPi (oMDP with interruptions). We obtain new complexity results, showing that oMDPi is NP-complete for at least two windows. While the complexity status of the single window oMDPi remains open, we propose a polynomial-time heuristic to solve it. We propose a hybrid heuristic to solve the general oMDPi, embedding a flow relaxation and a single window heuristic. The results on both real and realistic generated instances show that our heuristic achieves a significant reduction of memory peaks in a reasonable time compared to previous works, making the new policy attractive for future space missions.

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Fichiers liés : OMDPI__HAL_.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Marion FilliâtrePierre VoisinSeda SerenInes KelkoulOlivier GlehenPhilippe MelletSophie Thétiot-LaurentJean MenottiSylvain R A MarqueGérard AudranAbderrazzaq Bentaher
• Organismes : Institut de Chimie Radicalaire Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Institut de Chimie Radicalaire Institut de Chimie Radicalaire Institut de Chimie Radicalaire
• Publié dans Journal of Fungi le 24/10/2020

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Résumé : The emergence of antifungal-resistant Aspergillus fumigatus (A. fumigatus) became a serious public health concern, underscoring the need for new effective antifungal agents. Here, we present a strategy based on the in situ generation of radical species that are toxic to the pathogen. The synthesis of an alkoxyamine linked to a peptide substrate recognized by A. fumigatus-secreted dipeptidyl peptidase is described. Kinetic experiments show a stable prodrug prior to enzymatic activation. Ensuing peptide cleavage and spontaneous homolysis resulted in the generation of a stable nitroxide and a reactive alkyl radical moiety. Next, the exposure of A. fumigatus spores to the prodrug lead to pathogen growth inhibition in a compound concentration-dependent fashion (e.g., 42% inhibition at 10 µg/L). Importantly, the designed alkoxyamine inhibited not only the growth of a clinical voriconazole-susceptible A. fumigatus strain, but also the growth of a strain resistant to this azole. To determine the antifungal importance of the reactive alkyl radical, its substitution with a non-radical structure did not prevent A. fumigatus growth. Furthermore, the introduction of succinic group in the peptide substrate resulted in the loss of alkoxyamine antifungal properties. Our work reports a novel chemical strategy for antifungal therapy against A. fumigatus based on the pathogen enzyme-mediated generation of toxic radicals. Significantly, these findings are timely since they could overcome the emerged resistance to conventional drugs that are known to target defined pathogen biologic mechanisms such as ergosterol synthesis.

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Fichiers liés : jof-11-00503-v3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Angèle JeantyLaurent BoubyCyprien MureauLéa d'OliveiraCamille DhamCélia LecomteVincent BonhommeSarah IvorraNatàlia Alonso MartinezFerran AntolínRamon BuxóIsabel FigueiralCharlotte HallavantDani Lopez ReyesPhilippe MarinvalLucie MartinRachël Pinaud-Querrac’hNuria Rovira BuendiaMarie-Pierre RuasOdile PeyronJérôme RosAllowen Evin
• Organismes : Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Universitat de Lleida Université de Bâle = University of Basel = Basel Universität German Archaeological Institute Institut national de recherches archéologiques préventives Institut des Sciences de l'Evolution de Montpellier Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Archéologie des Sociétés Méditerranéennes Environnements, Dynamiques et Territoires de Montagne Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes BioArchéologie, Interactions Sociétés Environnements Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier
• Publié dans Philosophical Transactions of the Royal Society B: Biological Sciences le 02/11/2020

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Résumé : The past agrobiodiversity and evolution of barley, a staple cereal in the northwestern Mediterranean region for the last ca 8000 years, is still poorly documented. This study employed an intensive sampling strategy to analyse morphometric variation of 9817 grains (264 samples and 102 sites), dating from the Neolithic to the Late Middle Ages, from southern France and Catalonia. We utilized an archaeophenomic approach to quantify grain size and shape through elliptic Fourier transformation. We contrasted the variation of archaeological grains with that of 6397 caryopses from 105 modern Euro-Mediterranean varieties of 2-row/6-row subspecies, hulled/naked types. Past climate conditions in southern France/Catalonia were investigated to provide an environmental framework for interpreting morphometric variation. Barley grains increased in size, and changed in shape over time, likely owing to a combination of factors, including environmental adaptation and human selection, coupled with changes in agricultural practices. Naked barley was prevalent during the Neolithic, while the proportion of hulled barley increased from the Late Bronze Age onwards. In contrast, subspecies were identified in all assemblages, without clear temporal trends but with strong variation between assemblages. This study uncovers a complex interplay of environmental and human factors in cereal evolution, highlighting the evolution of agrobiodiversity that fuelled the development of modern societies. This article is part of the theme issue ‘Unravelling domestication: multi-disciplinary perspectives on human and non-human relationships in the past, present and future’.

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Fichiers liés : jeanty_2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Yao Jean Rodrigue KonanBi Tra Dieudonné TaDjakaridja BertéBamoro CoulibalyKinifo Donatien CoulibalyNick Steven EgnankonFoungniguée DiarrassoubaKouassi Albert DjaboStéphanie Watier-GrillotJean-Paul DemoncheauxKoffi Alain Demarie KouadioLouis N'DriPhilippe SolanoSophie RavelGuy Pacôme AdingraAntoine BarreauxAdeline SegardDramane KabaVincent JamonneauThierry de MeeusVincent Djohan
• Organismes : Université Félix Houphouët-Boigny Institut Pierre Richet Institut Pierre Richet Institut Pierre Richet Université Péléforo Gon Coulibaly Université Jean Lorougnon Guédé Institut Pierre Richet Institut Pierre Richet French Armed Forces Centre for Epidemiology and Public Health French Armed Forces Centre for Epidemiology and Public Health Institut Pierre Richet Institut Pierre Richet Institut de Recherche pour le Développement Institut de Recherche pour le Développement Institut Pierre Richet Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides Institut de Recherche pour le Développement Institut Pierre Richet Institut de Recherche pour le Développement Institut de Recherche pour le Développement Université Félix Houphouët-Boigny [Abidjan, Côte d'Ivoire]
• Publié dans Parasite le 02/11/2020

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Résumé : Vector control (VC) is one of the strategies employed to manage African trypanosomoses. This study aimed at assessing the effectiveness of a VC campaign against Glossina palpalis palpalis using tiny targets (TTs) impregnated with insecticide in an isolated, protected forest in Abidjan, Côte d'Ivoire, while considering ecological, genetic, and operational factors. Between January 2020 and September 2022, 2,712 TTs were deployed at 684 sites, covering a total area of 1.7 km2. VC monitoring was conducted using Vavoua traps during 12 evaluation surveys, between June 2020 and March 2023. Five months after the initial TT deployment, tsetse fly density had decreased by 98.53%. Although tsetse density remained low due to TT redeployment and reinforcement, there was a significant increase a few months after the last redeployment. VC appeared to have minimal impact on the genetic structuring of G. p. palpalis. This suggested recruitment of local surviving tsetse flies all along the VC campaign due to a low probability of tsetse coming into contact with TTs, or to the evolution of behavioral or physiological resistance to control efforts. The genetic study revealed that one of the microsatellite markers used, the GPCAG locus, exhibited a selection signature possibly in response to VC. This could partly explain the challenges encountered in eliminating a seemingly isolated tsetse population thriving in a particularly favorable habitat.

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Fichiers liés : Konan%20et%20al.%2C%202025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Massinissa BenyahiaChloé MagnanVincent Jean-PierreR. LarcherAdeline Boutet-DuboisMarie GaillardHélène MarchandinStéphanie GenieyzMadjid MorsliJean-Philippe LavigneAlix Pantel
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Virulence Bactérienne et Infections Chroniques Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hydrosciences Montpellier Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hydrosciences Montpellier Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Virulence Bactérienne et Infections Chroniques Virulence Bactérienne et Infections Chroniques
• Publié dans Annals of Clinical Microbiology and Antimicrobials le 30/10/2020

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Résumé : Background: Cefiderocol, a newly introduced siderophore cephalosporin, exhibits activity against various multidrug-resistant (MDR) Gram-negative bacilli (GNB), including producers of Ambler class A, B and D carbapenemases. The TROJAN-MDR study aimed to (i) compare the in vitro activity of cefiderocol with other last-resort antibiotics against a well-characterized collection of Enterobacterales and Pseudomonas aeruginosa strains from Southern France, and (ii) assess the performance of available cefiderocol antimicrobial susceptibility testing (AST) methods.Methods: The collection comprised 127 Enterobacterales from various clones, including 119 carbapenemase producers (93.7%), and 53 MDR P. aeruginosa. The minimum inhibitory concentrations (MICs) of cefiderocol were determined using the UMIC® broth microdilution method (BMD) as the reference. Comparators MICs were measured using Sensititre™ EUMDRXXF plates and Liofilchem strips for aztreonam-avibactam. Results were interpreted according to EUCAST breakpoints, with CLSI breakpoints also used for cefiderocol. The performance of the ComASP® BMD and disk diffusion on two different Mueller–Hinton media (Bio-Rad and BD) were evaluated according to ISO 20776-2:2007 and 2021.Results: Cefiderocol demonstrated potent activity on Enterobacterales (81.9% susceptible) and P. aeruginosa (84.9%) using EUCAST breakpoints. Among Enterobacterales, the most effective comparators were colistin, aztreonam-avibactam, meropenem-vaborbactam, and amikacin, with susceptibility rates of 99.2%, 98.4%, 85%, and 76.4%, respectively. For P. aeruginosa, only colistin exhibited better activity (100%). The disk diffusion method showed superior performance on BD medium compared to Bio-Rad. The ComASP® method did not provide sufficient performance to be considered reliable.Conclusions: Cefiderocol was highly active against a large collection of MDR GNB, including high-risk clones. It is crucial to assess susceptibility to this last-resort antibiotic using a validated method when considering clinical use

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Fichiers liés : 2025 Benyahia et al., TROJAN.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczYiming AbulaitiBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatt AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhMelike AkbiyikTorsten AkessonAndrei AkimovDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertPietro AlbicoccoGuillaume AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeJonny AllenJulia Frances AllenPhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesThiziri AmezzaDante AmideiBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosKieran Robert AmosDimitra AmperiadouShiwen AnChristos AnastopoulosTimothy Robert AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaKanae AsaiShoji AsaiNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupGiuseppe AvolioKonstantinos AxiotisGeorges AzuelosDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerPaolo BagnaiaMarzieh BahmaniDaniel BahnerKehang BaiJohn BainesLuke BainesKeith BakerEvelin BakosDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzIsaac BamwidhiElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosSergey BarsovFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosAlexander BasanMarta Baselga BacarditSaleh BashiriAhmed 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EllisJohannes ElmsheuserMai ElsawyMarkus ElsingDmitry EmeliyanovYuji EnariIrina EneShalini EpariDaniel Ernani Martins NetoFlorian ErnstMartin ErrenstMarc EscalierCarlos Escobar IbanezErez EtzionGuiomar Gaspar de Andrade EvansHal EvansLevi EvansAleksei EzhilovSanae EzzarqtouniFederica FabbriLaura FabbriGabriel FaciniVitaliy FadeyevRinat FakhrutdinovDionysios FakoudisSperanza FalcianoLuis Falda CoelhoFrancesco FallavollitaGregorio FalsettiJana FaltovaCunwei FanKa Yan FanYunyun FanYaquan FangMarcello FantiMohammed FarajZahra FarazpayAmir FarbinAda FarillaTrisha FarooqueJesse FarrSinead FarringtonFarida FassiDimitris FassouliotisLouis FayardPavol FedericPavla FedericovaOleg FedinMatthew FeickertLorenzo FeligioniDeion Elgin FellersCunfeng FengZhuoran FengMichael James FentonLars FerenczBeltran Fernandez BarbadilloPablo Fernandez MartinezMaxime FernouxJames FerrandoArnaud FerrariPamela FerrariRoberto FerrariDidier FerrereClaudio FerrettiMatthew FewellDavide FiaccoFrank FiedlerPetr 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GkialasLeonid GladilinClaudia GlasmanMarianna GlazewskaGediminas GlemzaMarija GlisicIvan GnesiYeonju GoMaximilian Emanuel Goblirsch-KolbBenedikt GockeDominique GodinBerare GokturkSteven GoldfarbTobias GollingMpho Gift Doctor GololoDmitry GolubkovJason Peter GombasAgostinho da Silva GomesGabriel GomesAntonio Jesus Gomez DelegidoRicardo Jose Morais Silva GoncaloLaura GonellaAlexi GongadzeFrancesco GonnellaJulia Lynne GonskiRichards GonzalezSantiago Gonzalez de la HozMarcus Vinicius Gonzalez RodriguesRebeca Gonzalez SuarezSergio Gonzalez SevillaLuc GoossensBenedetto GoriniEdoardo GoriniAndrej GorisekThomas Christopher GosartAl GoshawMikhail GostkinSoumyananda GoswamiCarlo Alberto GottardoStefanie Andrea GotzMohamed GouighriAnna GoussiouNicolin GovenderRadoslaw Piotr GrabarczykIwona Grabowska-BoldKevin Robert GrahamEirik GramstadSergio GrancagnoloCharles Michael GrantPaul GravilaFrancesco Giuseppe GraviliHeather GrayMatteo GrecoMatthew James GreenChristian GrefeAurora Singstad GrefsrudIngrid GregorKevin Thomas GreifPhilippe GrenierSimon Gabriel GreweAlex GrilloKaty GrimmSebastian GrinsteinJean-Francois GrivazEilam GrossJoern Grosse-KnetterLiang GuanGiovanni GuerrieriRuben GuevaraRalf GugelJem Aizen Mendiola GuhitAlessandro GuidaEva GuillotonStefan GuindonFangyi GuoJun GuoLinghua GuoLei GuoYuxiang GuoAnubhav GuptaRajat GuptaShubham GuptaSaime GurbuzSimran Sunil GurdasaniGiuliano GustavinoPhillip GutierrezLuis Felipe Gutierrez ZagazetaManuel GutscheChristian GutschowClaire GwenlanCarl GwilliamEven Simonsen HaalandAndrew HaasMartin HabedankCarl HaberHaleh HadavandAbdelhamid HaddadAsma HadefAlina HaganJan Joachim HahnEmil HainesMahsana HaleemJoseph HaleyGregory HallewellLea HalserKenji HamanoMatthias HamerSalah El Dine HammoudEmily HampshireJingyi HanLiangliang HanLiang HanShuo HanKazunori HanagakiMike HanceDhanush Anil HangalHamza HanifMichael Donald HankJorgen Beck HansenPeter HansenDaigo HaradaTorsten HarenbergSiarhei HarkushaMatthew Leary HarrisYnyr HarrisJack HarrisonNatalie Marie HarrisonPaul Fraser HarrisonMax HartNicole Michelle HartmanNikolai KrugRosie HasanYoji HasegawaFlorian HaslbeckSohaib HassanReiner HauserMatej HaviernikChris HawkesRichard HawkingsYuichiro HayashiDaniel HaydenChristopher Robyn HayesRobin HayesChris HaysJonathan HaysHelen HaywardMingxu HeYajun HeYi HeNathan HeatleyVincent HedbergConstantin HeideggerKim Katrin HeideggerJesse HeilmanSarah HeimTimon HeimJames Geddy HeinleinJochen Jens HeinrichLukas Alexander HeinrichJiri HejbalAlexander HeldSimen HellesundCole Michael HellingSten HellmanLars HenkelmannAna Maria Henriques CorreiaHannah Elizabeth HerdeYesenia Hernandez JimenezLena Maria HerrmannTim HerrmannGregor HertenRalf HertenbergerLuis HervasMoritz HespingNigel HesseyJohannes HesslerMourad HidaouiNihad HidicEwan Chin HillStephen HillierJulia Rose HindsFlorian HinterkeuserMinoru HiroseShigeki HiroseDominic HirschbuehlTom HitchingsBojan HitiJohn David HobbsRadu HobincuNoam Tal HodAnthony HodgesMark HodgkinsonBen HodkinsonAndreas HoeckerDustyn Dean HoferJudith HoferMichael HolzbockBart HommelsVid HomsakBenjamin Paul HonanJae Jin HongTae Min HongBenjamin Henry HoobermanWalter HopkinsMatthew Caleb HoppeschYasuyuki HoriiMalin Elisabeth HorstmannSuen HouMason Ray HousengaAlissa Shirley-Ann HowardJames William HowarthJoaquin HoyaMiroslav HrabovskyTetiana HrynovaPai-Hsien HsuShih-Chieh HsuTao HsuMiao HuQipeng HuShuhui HuangXinhui HuangYicong HuangYingjun HuangYan HuangYanping HuangZuchen HuangZdenek HubacekMichael HubnerFabian HueggingTodd Brian HuffmanMateus HufnagelCedrine Alexandra HugliMika HuhtinenSimon Kristian HuibertsRaphael Alain HulskenCharles Elliott HultquistNazim HuseynovJoey HustonJohn HuthRachel Jordan HynemanGiuseppe IacobucciGeorge IakovidisLydia Iconomidou-FayardJames Philip IddonPaolo IengoRyunosuke IguchiYutaro IiyamaTomoya IizawaYoichi IkegamiDimitrios IliadisNikolina IlicHajar ImamGuilherme Inacio GoncalvesSebastian Alonso Infante CabanasTom Ingebretsen 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Michael KnightAndrea Helen KnueMichael KobelDmitrii KobylianskiiSimon Florian KochMartin KocianPeter KodysDaniela KockThomas KoffasOrcun KolayIro KoletsouTomas KomarekKarsten KoenekeAlbert KongTakanori KonoNikolaos KonstantinidisPantelis KontaxakisBalazs KonyaRevital KopelianskyStefan Zenon KopernyKrzysztof Marian KorcylKostas KordasAndreas KornSteffen KornIlya KorolkovNatalia KorotkovaBryan KortmanOliver KortnerSandra KortnerWill KosteckaMatus KostovVadim KostyukhinAnastasia KotsokechagiaAshutosh KotwalAimilianos KoulourisAthina Kourkoumeli-CharalampidiChristine KourkoumelisVangelis KourlitisOndrej KovandaBob KowalewskiWitold KozaneckiAnatoli KozhinViktor KramarenkoGregor KrambergerPeter KramerMieczyslaw Witold KrasnyAttila KrasznahorkayArthur Charles KrausJohanna Wanda KrausJakub KremerNils Benedikt KrengelTom KresseLukas KretschmannJan KretzschmarKen Matthias KreulPeter KriegerKarol KrizkaKevin Alexander KroeningerHubert KrohaJiri KrollIra Joseph KrollKyle Stuart KrowpmanUladzimir 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• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique 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Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
• Publié dans Phys.Rev.D le 05/03/2026

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Résumé : A search for cascade decays of charged sleptons and sneutrinos using final states characterized by three leptons (electrons or muons) and missing transverse momentum is presented. The analysis is based on a dataset with 140 fb$^{-1}$ of proton-proton collisions at a center-of-mass energy of $\sqrt{s}$=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. This paper focuses on a supersymmetric scenario that is motivated by the muon anomalous magnetic moment observation, dark mattter relic density abundance, and electroweak naturalness. A mass spectrum involving light higgsinos and heavier sleptons with a bino at intermediate mass is targeted. No significant deviation from the Standard Model expectation is observed. This search enables to place stringent constraints on this model, excluding at the 95% confidence level charged slepton and sneutrino masses up to 450 GeV when assuming a lightest neutralino mass of 100 GeV and mass-degenerate selectrons, smuons and sneutrinos.

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