Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Raphaël GarinPierre-Jean BouvetBeatrice TomasiPhilippe ForjonelCharles Vanwynsberghe
• Organismes : Systèmes Embarqués, Acoustique et Télécommunications Systèmes Embarqués, Acoustique et Télécommunications Systèmes Embarqués, Acoustique et Télécommunications Norwegian Research Center Systèmes Embarqués, Acoustique et Télécommunications Systèmes Embarqués, Acoustique et Télécommunications Technology Innovation Institute [Abu Dhabi]
• Publié dans Journal of Marine Science and Engineering le 29/10/2020

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Résumé : Underwater unmanned vehicles are complementary with human presence and manned vehicles for deeper and more complex environments. An autonomous underwater vechicle (AUV) has automation and long-range capacity compared to a cable-guided remotely operated vehicle (ROV). Navigation of AUVs is challenging due to the high absorption of radio-frequency signals underwater and the absence of a global navigation satellite system (GNSS). As a result, most navigation algorithms rely on inertial and acoustic signals; precise localization is then costly in addition to being independent from acoustic data communication. The purpose of this paper is to propose and analyze the performance of a novel low-cost simultaneous communication and localization algorithm. The considered scenario consists of an AUV that acoustically sends sensor or status data to a single fixed beacon. By estimating the Doppler shift and the range from this data exchange, the algorithm can provide a location estimate of the AUV. Using a robust state estimator, we analyze the algorithm over a survey path used for AUV mission planning both in numerical simulations and at-sea experiments.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Bruno RevolThéo WillemanMarc ManceauVéronique Dumestre-TouletJean-Michel GaulierHélène Eysseric-GuérinNathalie Fouilhé Sam-LaïChadi AbbaraDelphine AllorgeJean-Claude AlvarezAlice AmelineAnne BarretEmilie BerlandCélian BertinThierry BesnardFabien BevalotCamille Billet-ChatenayAlexandra BoucherÉmilie BouquetJoanna BourgineBertrand BrunetAnne-Sylvie CaousAlexandre CesbronLauriane CharuelMarjorie ChezeAntony Citterio-QuentinPhilippe Collon-FabieEric DaillyAmélie DaveluyGrégory DeffontaineMartine DelageXavier DelavenneFlorence DescampsJuliette DescoeurGuillaume DeslandesMarc DeveauxBernadette DevosChristophe DocheCéline EidenAurélie FouleyYvan GaillardNicolas GambierCatherine GanièreMarie GérardinJean-Pierre GoulléPascal GuerardGuillaume HoizeyLuc HumbertLaurent ImbertMarie-France KerguerisPascal KintzFlorian KlinzigLaurence Labat-DeveauxBruno LacarelleChristian LacroixDenis LamiableMichel LavitReynald Le BoisselierAnne Le BouilCatherine Le MeurSandrine LefeuvreBénédicte LelièvreVéronique Lelong-BoulouardAnne-Sophie Lemaire-HurtelMagalie LoilierVincent LopezClaire Martin-MolinsHélène MartyOlivier MathieuJean-Claude Mathieu-DaudéYves MaurasNathalie MilanAurélie MoalIsabelle MorelPatrick MuraAnne-Laure Pelissier-AlicotGilbert PépinMartine PerrinAnne PeyreAlain PineauLiselotte PochardRop PokCatherine Ragoucy-SenglerRaphaël RayerNassima RedjimiEmilie RomanCarine RousselSandrine SabiniElodie SaussereauJulien Scala-BertolaPauline SibilleMichel SpadariJohan ThieryKarine TitierAlain TurcantPierrick VacherNicolas VenisseOphélie VieiraPascale Visinoni
• Organismes : Université Grenoble Alpes - UFR Médecine Centre Hospitalier Universitaire [CHU Grenoble] Hypoxie et PhysioPathologie Centre Hospitalier Universitaire [CHU Grenoble] Centre d'Investigation Clinique [Grenoble] Laboratoire ToxGen Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire [CHU Grenoble] Université Grenoble Alpes Centre Hospitalier Universitaire [CHU Grenoble] Département de Pharmacologie-Toxicologie [CHU Angers] Impact de l'environnement chimique sur la santé humaine - ULR 4483 Plateforme de spectrométrie de masse [Garches] Hôpital Raymond Poincaré [AP-HP] Institut de Médecine Légale [Strasbourg] Laboratoire de pharmacologie et toxicologie neurocardiovasculaire Centre Hospitalier Universitaire [CHU Grenoble] CHU Gabriel Montpied [Clermont-Ferrand] Université Clermont Auvergne Neuro-Dol Laboratoire Lat Lumtox Hospices Civils de Lyon Laboratoire de neurosciences expérimentales et cliniques [U 1084] CIC Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Service de pharmacologie clinique et vigilances [CHU de Poitiers] Département de Pharmacologie [CHU Caen] Université Jean Monnet - Saint-Étienne Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Institut de Neurosciences des Systèmes Institut de Neurosciences des Systèmes
• Publié dans Public Health le 26/10/2020

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Résumé : Objective: To describe analgesic-related deaths in France and report trends over a 10-year period. Study design: The DTA (“Décès Toxiques par Antalgiques”) register is a French database of analgesic-related deaths among people without a history of drug abuse, reported by forensic toxicology experts. Methods: We included analgesic-related deaths occurring from January 2013 to December 2022 in France. Subject demographic characteristics and medical history, forensic autopsy findings, and toxicology reports were evaluated. Results: Among the 1036 deceased individuals (mean [SD] age, 48.3 [15.6] years), there were slightly more women than men (M:F sex ratio, 0.89:1). Over the entire study period, tramadol was the leading cause of death, ahead of morphine. A relative increase in oxycodone-related mortality was observed (from 6.8% in 2013 to 21.1% in 2022) compared to a progressive decrease in tramadol, morphine, and codeine-related deaths (from 43.2%, 31.1% and 24.3% in 2013 to 37.5%, 26.6% and 20.3% in 2022, respectively). However, no statistically significant variations were found (Chi-squared tests of homogeneity). Other analgesics (buprenorphine, dihydrocodeine, fentanyl, gabapentin, ketamine, methadone, nefopam, and pregabalin) were also implicated in deaths, but with low and stable rates over the period studied. Conclusions: In France, no increase in fentanyl-related deaths and only a non-significant increase in oxycodone-related deaths were observed over the period 2013–2022. Tramadol was the leading cause of analgesic-related deaths throughout this period. Although close monitoring is still required, particularly for oxycodone, our data do not support the hypothesis of an opioid crisis in France.

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Fichiers liés : 1-s2.0-S0033350624003652-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Nicolas PeschanskiFlorian ZoresJacques BoddaertBénedicte DouayClément DelmasAmaury BroussierDelphine DouilletEmmanuelle BerthelotThomas GilbertCédric Gil-JardinéVincent AuffretLaure JolyJérémy GuénézanMichel GalinierMarion PépinPhilippe Le ConteNicolas GirerdFrédéric RocaMathieu OberlinPatrick JourdainGeoffroy RousseauNicolas LamblinBarbara VilloingFrédéric MouquetXavier DubucsFrançois RoubilleMaxime JonchierRémi SabatierSaïd LaribiMuriel SalvatTahar ChouihedJean-Baptiste Bouillon-MinoisAnthony ChauvinPierrick Le Borgne
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Groupe Médical Spécialisé Le Premium [Strasbourg] CHU Pitié-Salpêtrière [AP-HP] Hôpital Beaujon [AP-HP] Institut des Maladies Métaboliques et Casdiovasculaires Institut Mondor de Recherche Biomédicale MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Research on Healthcare Performance Institut de Santé Publique, d'Epidémiologie et de Développement Bordeaux population health Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Défaillance Cardiovasculaire Aiguë et Chronique Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Institut des Maladies Métaboliques et Casdiovasculaires Gériatrie [AP-HP Ambroise-Paré] Université de Versailles Saint-Quentin-en-Yvelines Université Paris-Saclay Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Endothélium, valvulopathies et insuffisance cardiaque CHU Rouen Centre Hospitalier de Sélestat - GHSO [Sélestat] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire [CHU Lille] AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Hôpital Privé Le Bois Ramsay Santé [Lille] Centre Hospitalier Universitaire de Toulouse Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Hôpitaux La Rochelle Ré Aunis [Groupe hospitalier littoral Atlantique] Service de cardiologie et de pathologie vasculaire [CHU Caen] CHU Trousseau [Tours] Centre Hospitalier Universitaire [CHU Grenoble] Défaillance Cardiovasculaire Aiguë et Chronique Laboratoire de Psychologie Sociale et Cognitive Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital de Hautepierre [Strasbourg]
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : Acute heart failure (AHF) is a complex, multifactorial syndromic condition that, until now, did not have a consensual definition [1], [2]. The difficulties in agreeing on a consensual definition of AHF also apply to research, since depending on the application of the field of investigation, the target populations concerned and the therapeutic goals or pathophysiological knowledge sought, the elements defining heart failure (HF) vary, especially among older patients. Thus, although the advent of echocardiography has made it possible to characterize disturbances in myocardial relaxation and altered ventricular filling, marking the birth of the concept of HF with preserved ejection fraction (HFpEF) versus HF with reduced ejection fraction (HFrEF), the different clinical presentations do not always make it possible to determine whether myocardial failure corresponds to a disease of ventricular filling of vascular origin [3].AHF is most often characterized by dyspnoea, lower limb oedema and/or intense asthenia. It is a common presentation in emergency departments (EDs) and has become a major public health problem as its incidence and prevalence rise in line with an aging population in all developed countries. AHF represents a growing medico-economic burden and is associated with high morbidity and mortality [4]. Currently, AHF is the main reason for hospital admissions in patients aged > 65 years and acute cardiogenic pulmonary oedema accounts for approximately 1% of ED visits [3], [4], involving approximately 200,000 patients per year in France (including 5% of the French population aged 75–85 years and 10% of those aged > 85 years) [5]. HF is a progressive pathology linked to aging, with mortality rising by 10% each year [6]. Indeed, the mortality rate remains appalling, reaching up to 12% during the hospital stay, 8–20% in the 2 months following hospitalization for an episode of AHF, and reaching 25–50% in the first 5 years after initial diagnosis. Moreover, mortality is increased in the presence of associated comorbidities such as anaemia, hypercholesterolemia or renal dysfunction, all of which become more frequent with age [3], [4], [6], [7].

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Fichiers liés : 2024 Peschanski et al., 2023 SFMU.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Hugo PeyreNicolas HoertelBaptiste PignonAli AmadJean-Luc RoelandtImane BenradiaPierre ThomasGuillaume VaivaPierre-Alexis GeoffroyEmilie OliéPhilippe Courtet
• Organismes : Centre d’Excellence sur l’Autisme et les Troubles Neurodéveloppement (CHU Montpellier) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Régional Universitaire [Montpellier] Institut de psychiatrie et neurosciences de Paris GHU AP-HP Centre Université Paris Cité Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor Fondation FondaMental [Créteil] Lille Neurosciences & Cognition - U 1172 Fédération régionale de la recherche en psychiatrie et santé mentale Hauts-de-France [Lille] Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables Centre Collaborateur de l'Organisation Mondiale de la Santé pour la recherche et la formation en santé mentale Etablissement Public de Santé Mentale de Lille-Métropole [Armentières] Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables Centre Collaborateur de l'Organisation Mondiale de la Santé pour la recherche et la formation en santé mentale Etablissement Public de Santé Mentale de Lille-Métropole [Armentières] Lille Neurosciences & Cognition - U 1172 Fédération régionale de la recherche en psychiatrie et santé mentale Hauts-de-France [Lille] Lille Neurosciences & Cognition - U 1172 Centre National de Ressources et de Résilience [Lille] Fédération régionale de la recherche en psychiatrie et santé mentale Hauts-de-France [Lille] AP-HP - Hôpital Bichat - Claude Bernard [Paris] GHU AP-HP Nord - Université Paris Cité Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Maladies neurodéveloppementales et neurovasculaires Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil]
• Publié dans Journal of Clinical Psychiatry le 27/10/2020

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Résumé : Background: This study explores among individuals with a major depressive episode (MDE) the potential impact of mixed features on the risk of suicide attempt, suicidal thoughts, self-harm intentions, and thoughts of death. Methods: Data from the French Mental Health in General Population (MHGP) survey (1999-2003) were analyzed, including 128 participants meeting DSM 5 criteria for MDE with mixed features (MDE with at least 3 manic symptoms) and 3,312 participants experiencing MDE without mixed features. Our primary analysis focused on suicide attempt, with additional examination of recent suicidal thoughts, self-harm intentions, and thoughts of death. Multivariable regression models were performed to adjust for potential confounding variables, including sociodemographics, previous suicide attempt, number of depressive symptoms, and psychiatric comorbidity. Results: MDE with mixed features was significantly associated with an increased risk of suicide attempt (adjusted odds ratio [AOR] = 1.69; 95% CI, 1.26-2.25). This association did not significantly differ between men and women. Furthermore, the number of manic symptoms demonstrated a dose-dependent relationship with an increased risk of suicide attempt (AOR = 1.18; 95% CI, 1.07-1.30; P < .001). Mixed features were also associated with suicide attempt among individuals with MDE and without recent suicidal thoughts (AOR = 2.74; 95% CI, 1.36-5.54). Conclusion: This study underscores the importance of assessing mixed features when evaluating the risk of suicide attempt in individuals with MDE. Mechanisms underlying this association might be independent of progression from thoughts of death to suicidal thoughts, suicidal intention, and ultimately, suicide attempt.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Mengjia WangPhilippe CiaisFrédéric FrappartShengli TaoLei FanRui SunXiaojun LiXiangzhuo LiuHuan WangWigneron J.-P.
• Organismes : Zhengzhou University Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Peking University [Beijing] Southwest University [Chongqing] Beijing Normal University Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Effective monitoring of soil and vegetation properties on a global scale is essential for better understanding climate changes, hydrological dynamics, and ecological processes. Passive microwave remote sensing at C-band radio frequency, with long observation period and relatively high penetration capability, has been widely used to retrieve soil moisture (SM) and vegetation optical depth (C-VOD). The retrieval process is generally achieved by inversion of the ti-w radiative transfer model, which depends on crucial parameters such as effective scattering albedo (w) and soil roughness (HR) R ) for accurate retrievals. Current SM/C-VOD retrieval algorithms, such as the Land Parameter Retrieval Model (LPRM), predominantly rely on globally-constant w and HR R values, ignoring the inherent sensitivity of those parameters to varying soil conditions and vegetation types. To evaluate the impact of w and HR R variables on SM and C-VOD retrievals and to improve their accuracy, this study proposed and evaluated a novel retrieval approach from AMSR2 C-band observations during 2017-2020 using the C-band Microwave Emission of the Biosphere (C-MEB) model. We evaluated two new retrieval algorithms, considering either a globally-constant calibration or a land cover-based calibration of w and HR. R . As a benchmark for the calibration, we optimized the values of w and HR R by evaluating the retrieved SM against in situ measurements from the International Soil Moisture Network (ISMN) and OzNet hydrological monitoring networks. The main originality compared to previous algorithms is that i) it includes a comprehensive calibration exploring the optimal values of w and HR, R , applicable globally or tailored to specific land cover; ii) field SM measurements were leveraged to constrain the calibrated value of w and HR. R . For the globally-constant calibration, the optimal values of w = 0.05 and HR R = 0.1 were found to yield the best results. For the land cover-based calibration, an inverse relationship between w/HR R and canopy height was observed, with w ranging from 0.04 to 0.06 and HR R ranging from 0.1 to 0.7 for heights between 0 and 30 m. The algorithm employing a land cover-based calibration (INRAE Bordeaux 2, IB2) exhibited better performance than the one utilizing a globally-constant calibration (INRAE Bordeaux 1, IB1) in evaluating retrieved SM against in situ measurements, as well as in evaluating C-VOD vs various vegetation variables including aboveground biomass (AGB), tree cover, canopy height and several optical vegetation indices. Comparison with LPRM suggested that our IB2 C-VOD retrievals present improved performances in terms of both spatial and temporal results with all considered vegetation variables (spatial correlation (R) between various vegetation variables and C-VOD of 0.76-0.83 for IB2 vs 0.69-0.79 for LPRM), and exhibited lower saturation effects when compared with AGB. In addition, the IB2 SM produced lower root mean squared error (RMSE) (0.147 vs 0.217 m3/m3), 3 /m 3 ), bias (-0.03 vs 0.09 m3/m3), 3 /m 3 ), and ubRMSE (0.066 vs 0.067 m3/m3) 3 /m 3 ) when compared with in situ measurements, although it showed a lower R compared to LPRM SM.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Marc CalvetYanni GunnellMagali DelmasRegis BraucherStéphane JailletPhilipp HäuselmannRomain DelunelPatrick SorriauxPierre VallaPhilippe Audra
• Organismes : Histoire naturelle de l'Homme préhistorique Environnement, Ville, Société Histoire naturelle de l'Homme préhistorique Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Environnements, Dynamiques et Territoires de Montagne Environnement, Ville, Société Total E&P Institut des Sciences de la Terre Laboratoire de Polytech Nice-Sophia
• Publié dans Earth-Science Reviews le 22/10/2020

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Résumé : This review explores the potential for establishing valley incision chronologies from alluviumfilled cave systems, and covers a total of 30 case studies since 1997. Caves in limestone develop very fast (~10^4 years) when conditions for bedrock solution are optimal, and many contain alluvium deposited by allogenic sinking streams, preserving the sediment thereafter for millions of years. Cave networks display a vertical succession of sub-horizontal passages which indicate past positions of the water table, with the stream in-and outlet caves indicating the former elevation of the adjacent valley floor. Abandoned cave levels are expected to multiply as valley incision increases local relief (descending speleogenesis), but sediment aggradation or glacier ice accumulation may also raise the local base level and flood older caves or generate new ones (ascending speleogenesis). Establishing the age of alluvial sediment hosted by caves relies on burial dating of quartz-rich clasts using two terrestrial cosmogenic nuclides (TCNs) -commonly 26Al and 10Be -measured in the same sample. Systematic examination of age-elevation data patterns in the existing literature reveals situations ranging from intuitively consistent valley incision histories to counter-intuitive age inversions and other anomalies. Here those anomalies are analyzed and classified in order to establish the extent to which the corresponding inconsistencies are avoidable, thereby providing a methodical catalogue of foreseeable difficulties and pitfalls. Three domains of uncertainty are emphasized. The first relates to karst processes: cave network geometry, cave passage response to vadose and phreatic processes, and diachronous links between cavity age and sediment. The multiple pathways of speleogenesis are reviewed. They highlight ambiguities behind the concept of 'cave level', which, as a proxy for baselevel paleoelevations, may be less precise than subaerial information provided by fluvial fill or strath terraces. The second source of uncertainty lies in the chronological information provided by the alluvium. Sediment dynamics in subterranean karst generate complicated stratigraphic configurations, with opportunities for postdepositional sediment reworking within or between cave levels. Furthermore, a TCN burial age is valid for a population of quartz grains but not necessarily for the entire stratigraphic sequence containing them nor for the cave that contains it. The third source of uncertainty lies in the burial dating method itself, because 26Al and 10Be nuclide inventories cannot unequivocally document whether older burial events might have occurred prior to final burial in the cave. The review recommends that (i) sampling strategies should be contingent on a diagnosis of speleogens and speleothems, and on a detailed sedimentological and stratigraphic analysis of the alluvial fills; (ii) dating should focus on individual bedload clasts rather than on sand because this helps to discriminate between pebble populations and to detect sediment mixing; (iii) 26Al/ 10Be ratios in modern channel alluvium and in older deposits stored in the catchment should be measured for the purpose of detecting whether certain features endemic to the sediment cascade could explain apparent burial age anomalies in the cave sediments. In situations where 26Al/ 10Be determinations generate wide age dispersion, four scenarios are discussed in which either the oldest or the youngest age should be retained.

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Fichiers liés : Calvet_et_al_2024_ESR_Valley_incision_chronologies_from_alluvium-filled_cave_systems..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Marie ArnaudMelissa BakhosCornelia RumpelMarie-France DignacNicolas BottinelliRichard J. NorbyPhilippe GeaironJonathan DebordePierre KostyrkaJulien GernigonJean-Christophe LemeslePierre Polsenaere
• Organismes : Laboratoire Environnement Ressources des Pertuis Charentais Institut d'écologie et des sciences de l'environnement de Paris Institut d'écologie et des sciences de l'environnement de Paris Institut d'écologie et des sciences de l'environnement de Paris Institut d'écologie et des sciences de l'environnement de Paris Laboratoire Environnement Ressources des Pertuis Charentais Laboratoire Environnement Ressources des Pertuis Charentais Laboratoire Environnement Ressources des Pertuis Charentais Réserve Naturelle Nationale Lilleau des Niges Ligue pour la Protection des Oiseaux Réserve Naturelle Nationale Lilleau des Niges Ligue pour la Protection des Oiseaux Laboratoire Environnement Ressources des Pertuis Charentais
• Publié dans Communications Earth & Environment le 27/10/2020

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Résumé : Salt marshes are among the most efficient blue carbon sinks worldwide. The fate of this carbon is uncertain due to limited knowledge about organic matter (OM) decomposition processes under sea-level rise. In an in-situ manipulative experiment, we compared salt marsh OM decomposition and quality across simulated sea-level scenarios (by modifying the inundation) and litter types (absorptive root, fine transportive root, leaves, and rhizomes of Halimione portulacoide) for 170 days. The litter decomposition varied only between the inundation treatments with the longest and shortest durations, while the decomposition differed significantly across litter types, with absorptive roots releasing up to 40% less carbon than other litters. Changes in lignin composition were minimal for absorptive roots and were unaffected by sea-level rise scenarios. Our study suggests that (i) current projections of sea-level rise are unlikely to decrease litter decomposition; (ii) separating litter types might lead to better assessments of salt marshes’ OM dynamics.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Kassandra ZachosOphélia GodinJaehyoung ChoiJae JungBruno AouizerateValérie AubinFrank BellivierR. Raoul BelzeauxPhilippe CourtetCaroline DubertretBruno EtainEmmanuel HaffenA. Antoine LefrerePierre-Michel LlorcaEmilie OliéMircea PolosanLudovic SamalinRaymund SchwanPaul RouxCaroline BarauJean Romain RichardRyad TamouzaMarion LeboyerAna AndreazzaB. EtainE. OliéMarion LeboyerE. HaffenPierre-Michel LlorcaV. BarteauS. BensalemO. GodinH. LaouamriK. SouryisS. HotierAmandine PelletierF. HergetaJ. PetrucciL. WillaumeF. BellivierV. HennionE. MarlingeJ. MeheustA. RichardM. CarminatiH. FrancisqueC. DubertretN. MazerC. PortalierC. ScognamiglioA. BingP. LaurentS. GardKatia M'BailaraC. ElkaelF. HoorelbekeI. MinoisJ. SportichN. da RosL. BoukhobzaP. CourtetS. DenatB. DeffinisD. DucasseM. GachetA. LengvenytéF. MolièreL. NassG. TarquiniA. LefrereE. MoreauJ. PastolF. GroppiH. PolomeniJ. BaubergL. LescalierI. MuraccioliA. SurayR. CohenJ.P. KahnM. MilazzoO. Wajsbrot-ElgrabliThierry BougerolA. PouchonA. BertrandB. FredembachA. SuisseQ. DenoualM. PolosanA.M. GalliotL. BrehonG. BonnyL. DurandV. FeugaN. KayserP. RouxV. AubinI. CussacM.A. DupontJ. LoftusI. MedecinL. SamalinP.M. LlorcaM. MennetrierT. BonnetD. LacelleM. VayssiéC. BealO. Blanc
• Organismes : University of Toronto IMRB - "Biologie du système neuromusculaire" [Créteil] Fondation FondaMental [Créteil] University of Toronto University of Toronto Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Hôpital Lariboisière-Fernand-Widal [APHP] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Université Sorbonne Paris Cité Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Fondation FondaMental [Créteil] Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] CHU Clermont-Ferrand Université Clermont Auvergne Institut Pascal Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire [CHU Grenoble] Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Université Clermont Auvergne Centre Psychothérapique de Nancy [Laxou] Imagerie Adaptative Diagnostique et Interventionnelle Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations Plateforme de Ressources Biologiques [Henri Mondor AP-HP, Créteil] Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor Fondation FondaMental [Créteil] University of Toronto Centre Psychothérapique de Nancy [Laxou] Centre Psychothérapique de Nancy [Laxou] Centre Psychothérapique de Nancy [Laxou] Centre Psychothérapique de Nancy [Laxou]
• Publié dans Journal of Affective Disorders le 31/10/2020

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Résumé : Background: Nutrition is largely affected in bipolar disorder (BD), however, there is a lack of understanding on the relationship between dietary categories, BD, and the prevalence of metabolic syndrome. The objective of this study is to examine dietary trends in BD and it is hypothesized that diets with increased consumption of seafood and high-fiber carbohydrates will be correlated to improved patient outcomes, and a lower frequency of metabolic syndrome. Methods: This retrospective cohort study includes two French cohorts. The primary cohort, FACE-BD, includes 268 stable BD patients. The second cohort, I-GIVE, includes healthy controls, both stable and acute BD and schizophrenia patients. Four dietary categories were assessed: meat, seafood, low-fiber and high-fiber carbohydrates. Dietary data from two food frequency questionnaires were normalized using min-max scaling and assessed using various statistical analyses. Results: In our primary cohort, the increased high-fiber carbohydrate consumption was correlated to lower prevalence of metabolic syndrome and improved mood. Low-fiber carbohydrate consumption is associated with higher BMI, while higher seafood consumption was correlated to improved mood and delayed age of onset. Results were not replicated in our secondary cohort. Limitations: Our populations were small and two different dietary questionnaires were used; thus, results were used to examine similarities in trends. Conclusions: Overall, various dietary trends were associated with metabolic syndrome, BMI, lactate, mood and age of onset. Improving our understanding of nutrition in BD can provide mechanistic insight, clinically relevant nutritional guidelines for precision medicine and ultimately improve the quality of lives for those with BD.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Mathieu EchivardJean-Marc SellalChloé ZilioxEloi MarijonPierre BordacharSylvain PlouxKarim BenaliChristelle MarquiéClémence DocqDidier KlugRomain EschalierBaptiste MailleJean-Claude DeharoDominique BabutyThibaud GenetEstelle GandjbakhchAntoine da CostaOlivier PiotDamien MinoisJean-Baptiste GourraudPierre MondolyPhilippe MaurySerge BovedaJean-Luc PasquiéRaphaël P MartinsChristophe LeclercqCharles GuenanciaGabriel LaurentMathieu BeckerJulien BertrandPhilippe ChevalierVladimir ManentiMaciej KubalaPascal DefayePeggy JaconAntoine DesbiollesMarc BadozLaurence Jesel-MorelNicolas LellouchePaul-Ursmar MilliezPaul OllitraultSamir FarehMatthieu BerckerJacques MansouratiBenoît Guy-MoyatJean-Pierre ChabertNicolas LuconiPierre-François WinumFrédéric AnselmeFabrice ExtramianaCamille DelahayeFrançois JourdaOlivier BizeauMathieu NasarreArnaud OlivierStéphane FromentinThibault VilleminOlivier LevavasseurNéfissa HammacheIsabelle Magnin-PoullHugues BlangyNicolas SadoulKévin DuarteNicolas GirerdChristian de Chillou
• Organismes : Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Service de Cardiologie [CHRU Nancy] Université de Lorraine Hôpital Européen Georges Pompidou [APHP] Paris-Centre de Recherche Cardiovasculaire Hôpital Haut-Lévêque [CHU Bordeaux] IHU-LIRYC Université de Bordeaux Hôpital Haut-Lévêque [CHU Bordeaux] IHU-LIRYC Université de Bordeaux IHU-LIRYC Hôpital Haut-Lévêque [CHU Bordeaux] Université de Bordeaux Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Université Clermont Auvergne CHU Clermont-Ferrand Hôpital de la Timone [CHU - APHM] Aix Marseille Université Hôpital de la Timone [CHU - APHM] Aix Marseille Université Centre Hospitalier Régional Universitaire de Tours Université de Tours Centre Hospitalier Régional Universitaire de Tours Université de Tours CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Université Jean Monnet - Saint-Étienne Centre cardiologique du Nord Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Service Cardiologie [CHU Toulouse] Service Cardiologie [CHU Toulouse] Communauté d'universités et établissements de Toulouse Institut des Maladies Métaboliques et Cardiovasculaires Clinique Pasteur [Toulouse] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Service de Cardiologie [CHU de Dijon] Université de Bourgogne Physiopathologie et épidémiologie cérébro-cardiovasculaires [Dijon] Service de Cardiologie [CHU de Dijon] Université de Bourgogne Centre hospitalier régional de Metz-Thionville Centre hospitalier régional de Metz-Thionville Hôpital Louis Pradel [CHU - HCL] Université Claude Bernard Lyon 1 Hôpital Privé Jacques Cartier [Massy] Centre Hospitalier Privé Claude Galien - Ramsay Santé CHU Amiens-Picardie Centre Hospitalier Universitaire [CHU Grenoble] Université Grenoble Alpes Centre Hospitalier Universitaire [CHU Grenoble] Université Grenoble Alpes Centre Hospitalier Universitaire [CHU Grenoble] Université Grenoble Alpes Centre Hospitalier Régional Universitaire de Besançon Université de Franche-Comté Hôpitaux Universitaires de Strasbourg Médecine Cardiovasculaire Translationnelle CHU Henri Mondor [Créteil] Université Paris-Est Créteil Val-de-Marne - Paris 12 Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital de la Croix-Rousse [CHU - HCL] Université Claude Bernard Lyon 1 Centre Hospitalier Boulogne-sur-mer Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques Université de Limoges CHU Limoges Université de Reims Champagne-Ardenne Hôpital universitaire Robert Debré [Reims] Université de Reims Champagne-Ardenne Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Nîmes Université de Rouen Normandie CHU Rouen CIC Hôpital Bichat Université Paris Cité Centre Hospitalier de Roubaix Centre hospitalier d'Auxerre Centre Hospitalier Regional d'Orléans Centre Hospitalier Regional d'Orléans Clinique Louis-Pasteur Hôpital Nord Franche-Comté [Hôpital de Trévenans] Polyclinique Reims-Bezannes Hôpital Nord-Ouest [Villefranche sur Saône] Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Université de Lorraine Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Service de Cardiologie [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Background and Aims Prophylactic implantable cardioverter–defibrillators (ICDs) are not recommended until left ventricular ejection fraction (LVEF) has been reassessed 40 to 90 days after an acute myocardial infarction. In the current therapeutic era, the prognosis of sustained ventricular arrhythmias (VAs) occurring during this early post-infarction phase (i.e. within 3 months of hospital discharge) has not yet been specifically evaluated in post-myocardial infarction patients with impaired LVEF. Such was the aim of this retrospective study. Methods Data analysis was based on a nationwide registry of 1032 consecutive patients with LVEF ≤ 35% after acute myocardial infarction who were implanted with an ICD after being prescribed a wearable cardioverter–defibrillator (WCD) for a period of 3 months upon discharge from hospital after the index infarction. Results ICDs were implanted either because a sustained VA occurred while on WCD (VA+/WCD, n = 72) or because LVEF remained ≤35% at the end of the early post-infarction phase (VA−/WCD, n = 960). The median follow-up was 30.9 months. Sustained VAs occurred within 1 year after ICD implantation in 22.2% and 3.5% of VA+/WCD and VA−/WCD patients, respectively (P < .0001). The adjusted multivariable analysis showed that sustained VAs while on WCD independently predicted recurrence of sustained VAs at 1 year (adjusted hazard ratio [HR] 6.91; 95% confidence interval [CI] 3.73–12.81; P < .0001) and at the end of follow-up (adjusted HR 3.86; 95% CI 2.37–6.30; P < .0001) as well as 1-year mortality (adjusted HR 2.86; 95% CI 1.28–6.39; P = .012). Conclusions In patients with LVEF ≤ 35%, sustained VA during the early post-infarction phase is predictive of recurrent sustained VAs and 1-year mortality.

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Fichiers liés : Manuscript EURHEARTJ-D-23-04158-R3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Ernesto Guerra-FarfanFlavia BorgesMohit BhandariYaiza Garcia-SanchezJorge NuñezJaume Mestre-TorresJordi Tomas-HernandezJordi Teixidor-SerraMariano Balaguer-CastroPablo CastillonAlfred DealbertJulio de Caso RodriguezHector AguadoEnrique GueradoEkaterine PopovaAna Claudia TonelliKumar BalasubramanianJessica VincentValerie HarveyEtri KocaqiGerard SlobogeanP.J. DevereauxLaurent VeevaeteBernard Le Polain De WarouxPatricia Lavand'HommeOlivier CornuKarim TribakJean YombiNassim TouilJigme BhutiaCarol ClinckaertDirk De ClippeleirMaike ReulAmeen PatelVikas TandonLeslie GauthierVictoria R.A. AvramMitchell WinemakerJustin de BeerDiane SimpsonAndrew WorsterKim AlvaradoKrysten GregusKelly LawrenceDarryl LeongPhilip JosephPatrick MagloireBenjamin DeheshiStuart BislandThomas WoodDaniel TushinskiDavid A.J. WilsonShariq HaiderKamal BaliClive KearonYannick Le ManachKamal BaliAnthony AdiliMaria TiboniJohn NearyDavid CowanVickas KhannaAmna ZakiJanet FarrellAnne Marie MacdonaldDavid ConenSteven C.W. WongArsha KarbassiDouglas WrightHarsha ShanthannaRyan CoughlinMoin KhanSpencer WikkerinkFaraaz QuraishiAbdel-Rahman LawendyWaleed KishtaEmil SchemitschTimothy CareyMark MacleodDavid SandersEdward VasarhelyiDebra BartleyGeorge DresserChristina TieszerRichard JenkinsonSteven ShadowitzJacques LeeStephen ChoiHans KrederMarkku NousiainenMonica KunzRavianne TuazonMopina ShrikumarBheeshma RaviDavid WassersteinDavid J.G. StephenDiane NamPatrick D.G. HenryGavin C.A. WoodStephen MannMelanie JaegerMarco L.A. SivilottiChristopher SmithChristopher FrankHeather GrantLeone PloegJeff YachMark HarrisonAaron CampbellRyan BicknellDavide BardanaRobert FeibelKatie McilquhamCatherine GallantSamantha HalmanVenkatesh ThiruganasambandamoorthSara RuggieroWilliam HaddenBrian P.J. ChenStephanie CoupalStephen McmahonLisa McleanHemant ShiraliSyed HaiderCrystal SmithEvan WattsDavid SantoneKevin KooAllan YeeAdemilola OyenubiAaron NauthEmil SchemitschTimothy DanielsSarah WardJeremy HallHenry AhnDaniel WhelanAmit AtreyAmir KhoshbinDavid PuskasKurt DrollClaude CullinanJubin PayendehTina LefrancoisLise MozzonTravis MarionMichael JackaJames GreeneMatthew MenonRobert StiegelmahrDerek DillaneMarleen IrwinLauren BeaupreChad ColesKelly TraskShelley MacdonaldJ.A.I. TrenholmWilliam OxnerC.G. RichardsonNiloofar DehghanMehdi SadoughiAchal SharmaNeil WhiteLoretta OlivieriStephen HuntThomas TurgeonEric BohmSarah TranStephen GiilckTom HupelPierre GuyPeter O'BrienAndrew DuncanGordon CrawfordJunlin HouYanrui ZhaoYang LiuLei ShanAnshi WuJuan MuñozPhilippe ChaudierMarion DouplatMichel Henri FessyVincent PiriouLucie LouboutinJean Stephane DavidArnaud FriggeriSebastien BeroudJean Marie FayetPaul LandaisFrankie Ka Li LeungChristian Xinshuo FangDennis King Hang YeeParag SanchetiChetan PradhanAtul PatilChetan PuramMadhav BorateKiran KudrimotiBharati AdhyeHimanshu DongreBobby JohnValsamma AbrahamRitesh PandeyArti RajkumarPreetha GeorgeAlen SigamaniManesh StephenNitheesh ChandranMohammed AshrafA.M. GeorgekuttyAhamad SulthanS. AdinarayananDeep SharmaSatish BarnawalSrinivasan SwaminathanPrasanna BidkarSandeep MishraJagdish MenonNiranjan MVarghese ZkSantosh HiremathMadhusudhan NcAbhijit JawaliKingsly GnanaduraiCarolin GeorgeAtarao MaddipatiMary KpVijay SharmaKamran FarooqueRajesh MalhotraSamarth MittalChavi SawhneyBabita GuptaPurva MathurShivanand GamangatiVijaylaxmi TripathyPrem MenonMandeep DhillonDevendra ChouhanSharanu PatilRavi NarayanPurushotham LalPrashanth BilchodSurya SinghUttam GattuRavi DashputraPrashant RahateMaurizio TurielGiuseppe De BlasioRiccardo AccettaPaolo PerazzoDaniele StellaMarika BonadiesChiara ColomboStefania FozzatoFabio PinoIlaria MorelliEleonora ColnaghiVincenzo SaliniGiuseppe DenaroLuigi BerettaGiacomo PlacellaGiuseppe GiardinaMirko BindaAnna MarcatoLuca GuzzettiFabio PiccirilloMaurizio CecconiH.M. KhorHou Yee LaiC.S. KumarK.H. CheeP.S. LohKit Mun TanSimmrat SinghLi Lian FooKomella PrakasamSook Hui ChawMeng-Li LeeJoanne H.L. NgimHuck Wee BoonIm Im ChinYdo KleinlugtenbeltEllie B.M. LandmanElvira FlikweertHerbert RoerdinkRoy B.G. BrokelmanHannie Elskamp-MeijermanMaarten HorstJan-Hein M.G. CobbenMasood UmerDilshad BegumAnila AnjumPervaiz HashmiTashfeen AhmedHaroon RashidMujahid KhattakRizwan RashidRiaz LakdawalaShahryar NoordinNaveed JumanRobyna KhanMuhammad RiazSyedah BokhariAyesha AlmasHussain WahabArif AliHammad KhanEraj KhanAamer Nabi NurKholood JanjuaSajjad OrakzaiAbdus KhanKhawaja MustafaMian SohailMuhammad UmarSiddra KhanMuhammad AshrafMuhammad KhanMuhammad ShirazAhmad FurganPaweł ŚlęczkaPiotr DąbekAdam KumońWojciech SatoraWojciech AmbrożyMariusz ŚwięchJacek RycombelAdrian GrzelakIlona Nowak- KózkaJaroslaw GucwaWaldemar MachalaMmampapatla RamokgopaGregory FirthMwalimu KareraMaria FourtounasVirsen SinghAnna BiscardiMuhammad IqbalRyan CampbellMatimba MalulekeCarien MollerLerato NhlapoSithombo MaqungoMargot FlintMarcin NejthardtSean ChettyRubendren NaidooErnesto Guerra-FarfanJordi Tomas-HernandezYaiza Garcia-SanchezMiriam Garrido CluaVicente Molero-GarciaJoan Minguell-MonyartJordi Teixidor-SerraMaria del Mar Villar-CasaresJordi Selga MarsaJuan Porcel-VazquezJose-Vicente Andres-PeiroMarc AguilarJaume Mestre-TorresMaria ColominaPatricia GuilabertM Luisa Paños GozaloLuis AbarcaNuria MartinGemma UsuaPedro Martinez-RipolM.A. Gonzalez PosadaPilar Lalueza-BrotoJudith Sanchez-RayaJorge Nuñez CamarenaAntoni Fraguas-CastanyMariano Balaguer-CastroPere TornerMontsant Jornet-GibertJorge Serrano-SanzJaume Cámara-CabreraMònica Salomó-DomènechChristian Yela-VerdúAnna Peig-FontLaura RicolAnna Carreras-CastañerLuis Martínez-SañudoSusana HerranzCarlos Feijoo-MassóMònica Sianes-GallénPablo CastillόnMartí BernausSaioa QuintasOlga GόmezJordi SalvadorJavier AbarcaCristina EstradaMarga NovellasMercè TorraAlfred DealbertOscar MachoAlexia IvanovEsther ValldoseraMarta ArroyoBorja PeyAntoni YusteLlorenç MateoJulio De CasoRafael AnayaJ.L. Higa-SansoneAngelica MillanVictoria BañosSergio Herrera-MateoJulio De CasoRafael AnayaJ.L. Higa-SansoneAngelica MillanVictoria BañosSergio Herrera-MateoHector AguadoGonzalo Martinez-MunicioRicardo LeónSilvia Santiago-ManiegaAna ZabalzaGregorio LabradorEnrique GueradoAlicia Ramirez-RoldanEncarnacion CruzJuan CanoJose BogalloPaphon SangasoongsongNoratep KulachoteNorachart SirisreetreeruxNachapan PengrungTheerawat ChalacheewaVanlapa ArnuntasupakulTeerapat YingchoncharoenBundit NaratreekoonMiriam KadrySurendini ThayaparanIhab AbdlazizArash AframianArjuna ImbuldeniyaRoya MovahediSherif OmranMarcela VizcaychipiPatricia CorreiaShashank PatilKevin HaireAmy S.E. MayorSally DillinghamLaura NicholsonMohamed ElnaggarJoby JohnShashi NanjayanMartyn ParkerSusan O'SullivanMeir MarmorAmir MatityahuRobert McclellanCurt ComstockAnthony DingPaul ToogoodGerard SlobogeanKatherine JosephRobert O'TooleMarcus SciadiniScott RyanMolly ClarkCharles CassidyKonstantin BalonovSergio BergeseLaura PhiefferAlicia Gonzalez-ZacariasAndrew Marcantonio
• Organismes : Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs
• Publié dans Injury le 27/10/2020

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Résumé : Background Hip fractures carry a substantial risk of complications and death. This study aimed to report the 90-day incidence of mortality, major perioperative complications and in-hospital timelines after a hip fracture in the Spanish HIP ATTACK-1 trial cohort, comparing with the non-Spanish cohort. Methods Prospective cohort study of Spanish patients nested in the HIP ATTACK-1 trial. The HIP ATTACK-1 was an international, randomized, controlled trial (17 countries, 69 hospitals, 7 in Spain, highest recruiting country). Patients were randomized to either accelerated surgery (goal of surgery within 6 h of diagnosis) or standard care. Participants were ≥45 years of age who presented with a low-energy hip fracture requiring surgery. Results Among 534 patients in the Spanish cohort, 69 (12.9 %) patients died at 90 days follow-up, compared to 225 (9.2 %) in the non-Spanish cohort (p = 0.009), mostly due to higher nonvascular related mortality. A composite of major postoperative complication occurred in 126 patients (23.6 %). The most common perioperative complications were myocardial injury (189 patients, 35.4 %), infection with no sepsis (86 patients, 16.1 %) and perioperative delirium (84 patients, 15.7 %); all these complication rates in Spain were significantly higher than the non-Spanish patients (29.2 % p = 0.005; 11.9 % p = 0.008 and 9.2 % p < 0.0001, respectively). Spanish cohort patients were older and had more comorbidities than the non-Spanish cohort, evidencing their greater frailty at baseline. Among Spanish patients, the median time from hip fracture diagnosis to surgery was 30.0 h (IQR 21.1–53.9) in the standard-care group, with 68.8 % of patients receiving surgery within 48 h of diagnosis. This median time was lower in the non-Spanish cohort (22.8 h, IQR 9.5–37.0), where 82.1 % of patients were operated within 48 h. Conclusions In the HIP ATTACK-1 trial, 1 in 8 patients died 90 days after a hip fracture in Spain. The most common complication after a hip fracture was myocardial injury, followed by infection and delirium. Spanish patients had worse outcomes than non-Spanish patients. Research needs to focus on new interventions such as accelerated surgery and perioperative troponin measurement with the appropriate investment of resources, to prevent and identify early these complications with a goal of improving mortality for this high-risk population. Level of evidence II

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