Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 25/10/2024
• Auteurs : Anna GueiderikhJérémy BaudeDavid BaronRenaud SchiappaSandrine KatsahianDamien MoreauMarc LauransJean-Emmanuel BibaultSarah KrepsPierre-Yves BondiauMagali QuivrinAlexis LépinoyDavid PasquierJean-Michel Hannoun-LeviPhilippe Giraud
• Organismes : Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Université Sorbonne Paris Cité Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Université Côte d'Azur Health data- and model- driven Knowledge Acquisition CIC - HEGP Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Institut de Cancérologie de Bourgogne Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Université de Lille Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité
• Publié dans Frontiers in Oncology le 26/10/2020

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Résumé : Background Nodes are the second site for prostate cancer recurrence. Whole-pelvic radiotherapy (WPRT) has shown superiority over nodal stereotactic body radiotherapy (SBRT) in two retrospective cohorts. We aimed to compare both modalities and assess factors associated with treatment outcomes. Materials and methods This retrospective multicentric cohort study included patients from five institutions spanning from 2010 to 2022. Patients had a history of prostatic adenocarcinoma classified as N0 M0 at diagnosis with a first nodal-only pelvic castration-sensitive recurrence. Failure-free survival (FFS) was defined as the time from the end of RT to the first failure event–biochemical or imaging recurrence, or death. Results A total of 147 patients (pts) were analyzed, mainly treated for a recurrence after initial prostatectomy (87%), with 64 (43.5%) undergoing SBRT and 83 (56.5%) undergoing WPRT. SBRT was chosen mainly for dosimetric constraints (67%) and was associated with a lower rate of concomitant androgen deprivation therapy (ADT) prescription. With a median follow-up of 68 months [inter-quartile range (IQR) = 51], FFS was significantly lower in the SBRT group (p < 0.0001). In multivariable analysis, WPRT and ADT were associated with a longer FFS. Factors associated with a longer FFS after SBRT included associated ADT, lower prostate-specific antigen (PSA) levels, a PSA doubling time >6 months, and a Gleason score <8. SBRT was associated with a lower rate of genitourinary and gastrointestinal grade ≥2 complications. Discussion For an isolated pelvic nodal prostate cancer recurrence, SBRT is associated with a shorter FFS compared to WPRT. SBRT is often more convenient for patients and leaves further pelvic salvage options available, so it can be explored as an option for well-informed patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/10/2024
• Auteurs : Leticia SarloCoraline DurouxYohann ClémentPierre LanteriFabien RossettiOlivier DavidAugustin TillementPhilippe GilletAgnès HagègeL. DavidMichel DumoulinRichard MarchalThéodore TillementFrançois LuxOlivier Tillement
• Organismes : iLM - Formation, élaboration de nanomatériaux et cristaux M&Wine Institut des Sciences Analytiques ISA-CheMod Institut des Sciences Analytiques Université Claude Bernard Lyon 1 iLM - Formation, élaboration de nanomatériaux et cristaux [GIN] Grenoble Institut des Neurosciences Institut de Neurosciences des Systèmes iLM - Formation, élaboration de nanomatériaux et cristaux Nano-H Université Paris-Saclay ISA-Separative Methods - Techniques séparatives Ingénierie des Matériaux Polymères Laboratoire d'Oenologie et de Chimie Appliquée M&Wine iLM - Formation, élaboration de nanomatériaux et cristaux iLM - Formation, élaboration de nanomatériaux et cristaux
• Publié dans OENO One le 28/10/2020

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Résumé : For the wine industry, ensuring quality and authenticity hinges on the precise determination of wine origin. In our study, we developed a fast semi-quantitative method to analyse 41 chemical elements in wine, employing inductively coupled plasma mass spectrometry (ICP-MS). This methodology characterises what we term the mineral wine profile (MWP). In contrast to an organic molecular profile, the mineral composition of a wine remains constant from the moment it is bottled. Mineral elements play a crucial role in the terroir of wine: they pass primarily from soil to grape and are then influenced by various vinification techniques. Indeed, it is widely recognised that the original soil characteristics are altered by a multitude of winemaking procedures, presenting a considerable challenge when endeavouring to extract origin-related information in a typical scenario. Our study demonstrates that statistical analyses and artificial intelligence (AI) could be a tool for accurately deciphering origin information within the MWP, provided sufficient mineral elements are measured and a comprehensive database of wine samples is employed to establish effective learning. In this study, a dataset comprising 12,966 MWPs was created in just over a year. The first analysis revealed correlations between the elements in wine, especially between rare earth elements, between macronutrients and between micronutrients. A machine learning method was then developed to assess wine origin and principal grape variety. Six models were tested by comparing the area under the receiver operating characteristic curve (AUC), with eXtreme Gradient Boosting as the chosen model. Mean accuracies of 92 % for country classification, 91 % for the French wine region, and 85 % for the main grape variety were obtained, and mean AUC scores of 0.964 for country classification, 0.961 for the French wine region and 0.914 for the main grape variety. This study represents the first comprehensive investigation at this scale on wine samples, and underscores the importance of using a comprehensive MWP dataset for AI applications when verifying wine origin. The authentication of a wine with over 99 % specificity could be routinely achievable through this approach.

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Fichiers liés : 2024_OenoOne_Sarlo.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/10/2024
• Auteurs : Philippe BrunChristophe Quézel-Ambrunaz
• Organismes : Institut de l'Ouest : Droit et Europe Institut universitaire de France Centre de Recherche en Droit Antoine Favre
• Publié dans Lexbase Droit privé le 02/06/2022

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Résumé : En juillet 2005, un groupe de travail chargé d’élaborer une nomenclature des préjudices corporels, présidé par Jean-Pierre Dintilhac, a remis un rapport d’une soixantaine de pages. La nomenclature proposée a immédiatement été baptisée « Nomenclature Dintilhac » et a été très rapidement adoptée par les acteurs du droit du dommage corporel. Philippe Brun et Christophe Quézel-Ambrunaz conversent sur les presque vingt ans d’utilisation de celle-ci.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/10/2024
• Auteurs : Modan TailleurVincent LostanlenJean-Philippe RivièrePierre Aumond
• Organismes : Laboratoire des Sciences du Numérique de Nantes NANTES UNIVERSITÉ - École Centrale de Nantes Signal, IMage et Son Laboratoire des Sciences du Numérique de Nantes Signal, IMage et Son NANTES UNIVERSITÉ - École Centrale de Nantes Nantes Université Nantes Université - UFR Faculté des Langues et Cultures Etrangères Laboratoire des Sciences du Numérique de Nantes Perception, Action, Cognition pour la Conception et l’Ergonomie Unité Mixte de Recherche en Acoustique Environnementale

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Résumé : Oxygenators, alarm devices, and footsteps are some of the most common sound sources in a hospital. Detecting them has scientific value for environmental psychology but comes with challenges of its own: namely, privacy preservation and limited labeled data. In this paper, we address these two challenges via a combination of edge computing and cloud computing. For privacy preservation, we have designed an acoustic sensor which computes third-octave spectrograms on the fly instead of recording audio waveforms. For sample-efficient machine learning, we have repurposed a pretrained audio neural network (PANN) via spectral transcoding and label space adaptation. A small-scale study in a neonatological intensive care unit (NICU) confirms that the time series of detected events align with another modality of measurement: i.e., electronic badges for parents and healthcare professionals. Hence, this paper demonstrates the feasibility of polyphonic machine listening in a hospital ward while guaranteeing privacy by design.

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Fichiers liés : tailleur2024dcase.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 18/10/2024
• Auteurs : Edern De BarrosPhilippe CharpentierPierre-Éric FageolAnne-Claire HusserCharles MercierÉmilie PontanierGeorgeta StoicaGabriela Valente
• Organismes : Institut de droit public, sciences politiques et sociales Institut Coopératif Austral de Recherche en Éducation Université de Mayotte (UMay) Institut Coopératif Austral de Recherche en Éducation Education, Cultures, Politiques Université Claude Bernard Lyon 1 Institut national supérieur du professorat et de l'éducation - Académie de Lyon Institut National Supérieur du Professorat et de l'Education de l'Académie de Bordeaux Déplacements, Identités, Regards, Écritures Institut Coopératif Austral de Recherche en Éducation Education, Formation, Travail, Savoirs

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• Type de publi. : Article dans une revue
• Date de publi. : 18/10/2024
• Auteurs : Bamba GayeNzechukwu Michael IsiozorGurbinder SinghNgone Diaba GayeMame Madjiguene KaDaouda SeckKhadidiatou GueyeDavid Lagoro KitaraCamille LassaleAnne MalickMor DiawSidy SeckAbdourahmane SowMagaye GayeAbdou Salam FallAïda DiongueIbrahima SeckJamal BelkhadirIssa WoneSerigne Magueye GueyePapa Salif SowJamal Eddine KohenDorothea VogelsangMaïmouna Ndour MbayeElisabeth Alice LiyongAndré Pascal KengneRoberta LampteyNdeye Marième SougouEugène SobngwiAwa BaJohn TukakiraThiess LorenzElise KaboreMalaizyo Gabriel MuzumalaAhmed OlanrewajuLamin Es JaitehLucrèce Delicat-LoembetAimée Olivat Rakoto AlsonKhadim NiangCiira Wa MainaErnest MwebazeJoyce NabendeDina MachuvePrestone AdieFatoumata HanneRoger TineMarième SougouKouassi Gustave KoffiLameck LuwandaElisabeth Lilian Pia SattlerDemeke MekonnenFatma EbeidJean Paul EnamaMohamadi ZebaFernand GuedouPascal MbelessoJennifer CarterBakary CoulibalyMohamed Lamine DrameAlain MouangaPierre-Marie PreuxPhilippe LacroixMouhamadou DiaganaDidier Koumavi EkoueviDismand Stephan HouinatoAdama FayeVivien WambuguJean KamatéMathias LalikaElaine NsoesieBoni Maxime AleIbrahima Socé FallAbdoulaye SambLéon TshiloloModou Jobe
• Organismes : Université Cheikh Anta Diop de Dakar [Sénégal] Institut Pasteur de Dakar Centre Hospitalier National et Universitaire de Fann-Dakar [Dakar, Sénégal] Gulu University [Gulu, Uganda] Institute of Health Carlos III Hospital del Mar Medical Research Institute Ministère de la Santé et de l'Action sociale (Sénégal) Université Cheikh Anta Diop de Dakar [Sénégal] Université Gaston Berger de Saint-Louis Sénégal Institut Pasteur de Dakar Université Cheikh Anta Diop de Dakar [Sénégal] Institut Fondamental d'Afrique Noire Agence Nationale de l’Aviation Civile et de la Météorologie Université Cheikh Anta Diop de Dakar [Sénégal] Université Assane Seck de Ziguinchor [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Centre Hospitalier National et Universitaire de Fann-Dakar [Dakar, Sénégal] Université Internationale Abulcasis des Sciences de la Santé Maastricht University [Maastricht] Université Cheikh Anta Diop de Dakar [Sénégal] Korle-BU Teaching Hospital [Accra] Université Cheikh Anta Diop de Dakar [Sénégal] University of Yaoundé 1 = Université de Yaoundé I Université Alioune Diop de Bambey University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] Centre Hospitalier Universitaire Yalgado Ouédraogo [Ouagadougou, Burkina Faso] University of Zambia [Lusaka] University of Ibadan Edward Francis Small Teaching Hospital [Banjul, Gambia] Université des Sciences et Techniques de Masuku Université d'Antananarivo Université Gaston Berger de Saint-Louis Sénégal Dedan Kimathi University of Technology Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] School of Life Sciences and Bio-Engineering [Arusha] Université Assane Seck de Ziguinchor [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Centre Hospitalier Universitaire de Yopougon Attié [Abidjan] University of Georgia [USA] Laboratory of Chronic and Neurological Diseases Epidemiology Hôpital de l'Amitié [Bangui] University of Oxford Université Marien-Ngouabi [Université de Brazzaville] = Marien Ngouabi University [University of Brazzaville] Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Université de Lomé [Togo] Epidémiologie des Maladies Chroniques en zone tropicale Université Cheikh Anta Diop de Dakar [Sénégal] Duke University [Durham] Mayo Clinic [Rochester] Boston University [Boston] University of Nairobi Médecins sans Frontières [Genève] Université Cheikh Anta Diop de Dakar [Sénégal] Université Officielle de Mbujimayi
• Publié dans Journal of Global Health le 27/12/2018

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• Type de publi. : Article dans une revue
• Date de publi. : 18/10/2024
• Auteurs : Bamba GayeNzechukwu Michael IsiozorGurbinder SinghNgone Diaba GayeMame Madjiguene KaDaouda SeckKhadidiatou GueyeDavid Lagoro KitaraCamille LassaleAnne MalickMor DiawSidy M SeckAbdourahmane SowMagaye GayeAbdou Salam FallAïda DiongueIbrahima SeckJamal BelkhadirIssa WoneSerigne Magueye GueyePapa Salif SowJamal Eddine KohenDorothea VogelsangMaïmouna Ndour MbayeElisabeth Alice LiyongAndré Pascal KengneRoberta LampteyNdeye Marième SougouEugène SobngwiAwa BaJohn TukakiraThiess LorenzElise G KaboreMalaizyo Gabriel MuzumalaAhmed OlanrewajuLamin Es JaitehLucrèce M Delicat-LoembetAimée Olivat Rakoto AlsonKhadim NiangCiira Wa MainaErnest MwebazeJoyce NabendeDina MachuvePrestone AdieFatoumata HanneRoger TineMarième SougouKouassi Gustave KoffiLameck LuwandaElisabeth Lilian Pia SattlerDemeke MekonnenFatma EbeidJean Paul EnamaMohamadi ZebaFernand GuedouPascal MbelessoJennifer CarterBakary CoulibalyMohamed Lamine DrameAlain MouangaPierre-Marie PreuxPhilippe LacroixMouhamadou DiaganaDidier Koumavi EkoueviDismand Stephan HouinatoAdama FayeVivien WambuguJean KamatéMathias LalikaElaine NsoesieBoni Maxime AleIbrahima Socé FallAbdoulaye SambLéon TshiloloModou Jobe
• Organismes : Unité Mixte Internationale "Environnement Santé Sociétés" Neuroépidémiologie Tropicale Epidémiologie des Maladies Chroniques en zone tropicale Neuroépidémiologie Tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Journal of Global Health le 27/12/2018

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Résumé : African researchers continue to face numerous barriers that limit the global dissemination and advancement of their research. These include high open-access publication fees, requirements for publishing in high-impact journals, inability to attend or host international conferences, and limited access to published papers and resources. In this viewpoint, we focus on the specific challenge of attending international scientific conferences hosted in high-income settings and aim to propose practical solutions to address this inequity. The related barriers include visa-related difficulties and prohibitive travel expenses (e.g. non-reimbursable high visa fees, flight tickets, accommodation and subsistence, and conference registration costs).

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Fichiers liés : jogh-14-03042.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/10/2024
• Auteurs : Patrice ChevallierThibaut LeguayMarc DelordCyril SalekRathana KimFrançoise HuguetYosr HicheriUlla Wartiovaara-KauttoEmmanuel RaffouxThomas CluzeauMarie BalsatGabrielle Roth-GuepinEmmanuelle TavernierStephane LepretreKarin BilgerHugo BergugnatAna BerceanuMagda AlexisMichael DoubekEolia BrissotMathilde Hunault-BergerDelphine LebonPascal TurlureSylvain ChantepieAmine BelhabriStefan WickenhauserJean-Noel BastieVictoria CacheuxChantal HimberlinAnne BanosClaude GardinSarah BonnetIsabelle PlantierGian Matteo PicaMartine Escoffre-BarbeNicolas BoisselHervé DombretEmmanuelle ClappierPhilippe RousselotAmandine CharbonnierDeborah AssouanAmandine HubertMarine QuintFulvia Guenbem KossiElodie DerucheMathilde Hunault-BergerCéline MarieAnne BanosJean-Baptiste RobinJulie GayClaudie CapdupuySévérine LabarrereEdith VincentMarion Simonet-BoissardAna BerceanuFabrice LarosaYohan DesbrossesGuillaume BoiteuxVinciane DufourElise TissotThorsten BraunPr Claude GardinValérie VidalGeoffrey EdouartSylvain ChantepieJean-Pierre VilqueHyacinthe Johnson AnsahAngélique LebouvierMarie Charlotte ZapaloviczLéa RenaultPica Gian MatteoAlix CourouauFabienne PrieurCharlene DupreVictoria CacheuxBenoit de RenzisCarine ChaleteixAmandine FayardGwendoline RoyJean-Noël BastieDenis CaillotLaetitia DevauxPatrice ChevallierAmandine LebourgeoisAntoine BonnetPierre PeterlinAnne LokThierry GuilllaumeAlexis Morice FontainePascal TurlureMohamed TouatiCéline KennelNatalya DmytruckJulie AbrahamArnaud JaccardLiliane RemenierasStéphane GiraultMarie Pierre GourinAmélie PenotStéphane MoreauCéline PhiliponDelphine RocheAmine BelhabriLila GilisNicolas VirelizierAnne-Sophie MichaletJérémy MonfrayMarie BalsatXavier ThomasAline PraireGabrielle Roth GuepinCaroline BonmatiCharline MoulinCaroline JacquetAnne CarpodomiHélène BouilletOdile CarpentierMélanie MonteroAude PiresLauris GastaudAnastasia GamaCéline CoelleSonia KarmoutThomas CluzeauMichael LoschiJessica LechardeurHatroubi ChokriLoic BroussotStefan WickenhauserAgathe WaulthierEric JourdanElodie SchermanDiane UmuhireMaria Alessandra DamianoYors HicheriColombe SaillardEvelyne d'IncanMarie-Anne HospitalJean Laurent l'AttentionMme Nassima RabahLaura Castillo CesariEve GehlkopfLaure VincentRobert NavarroPhilippe QuittetNathalie FegueuxPatrice CeballosFanny Baguet MarinVéra SabadashMagda AlexisMarlène OchmannNina Akakelyan LaboureOmar BembrahmiOlivier MichelBrahim OuahrawiEolia BrissotOlivier LegrandAnne VekhoffFrançoise IsnardSara SaHervé DombretEmmanuel RaffouxEtienne LenguineFlorence RabianKarine Celli LebrasCatherine FauvauxThibaut LeguayFrançois-Xavier GrosTitouan CazaubielCyril MelotValentin DematteisAntonella MessinaChantal HimberlinQuoc-Hung LeLucia MaggiMartine Escoffre BarreAline MoignetSophie de GuibertMarc BernardOlivier DecauxThierry Lamy de la ChapelleStanislas NimubonaMme Erica KadendeAloyse FlavignyIsabelle PlantierLaurence DetourmigniesMathieu WemeauIsabelle DerviteKathy DernivoixMme CamilleIngrid DenizartStéphane LepretreAspasia Stamatoullas-BastardMarie-Laure FontouraFabrice JardinAnne-Lise MenardVincent CamusHelene LanicNathalie ContentinNathalie CardinaelEmilie Lemasle-HueMustafa AlaniPierre LebretonYoucef AtiaKarin BilgerMarie-Pierre LedouxCécile SonntagCamille CollinEmmanuelle TavernierDenis GuyotatGilbert SogluCaroline Le JeuneJérôme CornillonCoralie DurieuxCéline LavouéDorante MilerFrançoise HuguetSuzanne TavitianJustine SoldanPhilippe RousselotSophie RigaudeauLaure PhilippeJuliette LambertCaroline BessonAurélie CabannesThomas LongvalAnne-Laure TaksinMariama BahAnaïs BeulaygueMichael DoubekFrantisek FolberStepan HrabovskyJana BrzonovaHana VejsadovaCyril SalekElena NovotovaJolana MertovaJana BrzonovaHana VejsadovaUlla Wartiovaara-KauttoMinna SalonenSaara Vaalas
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Haut-Lévêque [CHU Bordeaux] Immunologie humaine, physiopathologie & immunothérapie Institute of Hematology and Blood Transfusion Génomes, biologie cellulaire et thérapeutiques Institut Universitaire du Cancer de Toulouse - Oncopole Service Hématologie - IUCT-Oncopole [CHU Toulouse] Institut Paoli-Calmettes Génomes, biologie cellulaire et thérapeutiques Hopital Saint-Louis [AP-HP] Université Côte d'Azur Centre Hospitalier Universitaire de Nice Centre Hospitalier Lyon Sud [CHU - HCL] Centre Hospitalier Régional Universitaire de Nancy Institut de Cancérologie de la Loire Lucien Neuwirth Service d'hématologie [CRLCC Henri Becquerel] Hôpitaux Universitaires de Strasbourg Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Regional d'Orléans Masaryk University [Brno] = Masarykova univerzita [Brno] = Université Masaryk [Brno] Central European Institute of Technology [Brno] University Hospital Brno Centre de Recherche Saint-Antoine CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 CHU Amiens-Picardie
• Publié dans Journal of Clinical Oncology le 01/11/2020

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Résumé : PURPOSE The use of inotuzumab ozogamicin (InO), a conjugated anti-CD22 monoclonal antibody, is becoming a promising frontline treatment for older patients with ALL. PATIENTS AND METHODS EWALL-INO is an open-label prospective multicenter phase II trial (ClinicalTrials.gov identifier: NCT03249870 ). Patients age 55 years and older with newly diagnosed CD22 + Philadelphia chromosome–negative (Ph–) B-cell precursor (BCP) ALL were eligible. After a prephase, a first induction consisting of vincristine, dexamethasone, and three injections of InO (0.8 mg/m 2 day 1, 0.5 mg/m 2 day 8/day 15) was followed by a second induction combining cyclophosphamide, dexamethasone, and two injections of InO (0.5 mg/m 2 day 1/day 8). Responders received up to six cycles of chemotherapy consolidation and 18-month chemotherapy maintenance. Allotransplant was allowed after three consolidations. The primary end point was 1-year overall survival (OS). RESULTS Between December 2017 and March 2022, 131 patients (median age 68 years) were included. Three patients died during induction 1 (n = 130), two from multiple organ failure and one from hemorrhage, and none during induction 2 (n = 120). After induction 2, 90% of the patients achieved complete remission (CR) or CR with incomplete platelet recovery (CRp) and 80% had measurable residual disease (MRD2) <10 −4 . Among responders (n = 119), 47 relapsed and 14 died in CR/CRp. One-year OS, relapse-free survival (RFS), and cumulative incidence of relapse (CIR) rates were 73.2%, 66%, and 25%, respectively. High-risk cytogenetics and lower CD22 expression (<70%) were associated with worse OS, while both high-risk cytogenetics and MRD2 ≥10 −4 were associated with lower RFS and higher CIR. The 10 allotransplanted patients had very favorable outcomes (90% 2-year OS/RFS and no relapse). Only one nonfatal sinusoidal obstructive syndrome was documented during the study. CONCLUSION Our results support InO's use in first-line regimens for older patients with CD22 + Ph– BCP-ALL.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/10/2024
• Auteurs : Pierre-Antoine BeauvaisDidier BinderFrançoise BostynJean-Philippe CollinElsa DefranouldVincent DelvignePaul FernandesAlix GibaudMikaël Guiavarc'HMarie ImbeauxCéline Bressy-LeandriFrançois-Xavier Le BourdonnecLudovic MevelAntoine PasqualiniStéphane RenaultAntonin TomassoChristophe TufféryErwan Vaissié
• Organismes : Technologie et Ethnologie des Mondes Préhistoriques University of Cape Town Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Université Paris 1 Panthéon-Sorbonne Centre de recherches en archéologie et patrimoine Trajectoires - UMR 8215 Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Technologie et Ethnologie des Mondes Préhistoriques Paléotime Technologie et Ethnologie des Mondes Préhistoriques Laboratoire méditerranéen de préhistoire Europe-Afrique Centre de Recherche en Archéologie, Archéosciences, Histoire Archéologie, Terre, Histoire, Sociétés [Dijon] Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Ministère de la Culture Archéosciences Bordeaux Technologie et Ethnologie des Mondes Préhistoriques Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Laboratoire méditerranéen de préhistoire Europe-Afrique Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Centre National de la Recherche Scientifique Université Côte d'Azur Technologie et Ethnologie des Mondes Préhistoriques Ministère de la Culture Archéologies et Sciences de l'Antiquité De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 15/10/2024
• Auteurs : Armen TumasyanWolfgang AdamJanik Walter AndrejkovicThomas BergauerSuman ChatterjeeKonstantinos DamanakisMarko DragicevicAlberto Escalante del VallePriya Sajid HussainManfred JeitlerNatascha KrammerLukas LechnerDietrich LikoIvan MikulecPeter PaulitschFlorian Michael PittersJochen SchieckRobert SchöfbeckDennis SchwarzMangesh SonawaneSebastian TemplWolfgang WaltenbergerClaudia-Elisabeth WulzMohamed Rashad DarwishTahys JanssenTomas KelloHaifa Rejeb SfarPierre van MechelenEmil Sørensen BolsJorgen d'HondtAlexandre de MoorMartin DelcourtHesham El FahamSteven LowetteSeth MoortgatAlexander MortonDenise MüllerAbanti Ranadhir SahasransuStefaan TavernierWalter van DoninckDavid VanneromBarbara ClerbauxGilles de LentdeckerLaurent FavartDmytro HohovJohny JaramilloKyeongpil LeeMostafa MahdavikhorramiInna MakarenkoAndrea MalaraSantiago ParedesLaurent PétréNicolas PostiauLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerDidar DoburJoscha KnolleLuka LambrechtGianny MestdachCésar RendónAmrutha SamalanKirill SkovpenMichael TytgatNiels van den BosscheBasile VermassenLiam WezenbeekAnna BeneckeGiacomo BrunoFlorian Joel J BuryClaudio CaputoPieter DavidChristophe DelaereIzzeddin Suat DonertasAndrea GiammancoKhawla JaffelSandhya JainVincent LemaitreKuntal MondalAngela TaliercioTu Thong TranPietro VischiaSébastien WertzGilvan AlvesEduardo CoelhoCarsten HenselArthur MoraesPatricia Rebello TelesWalter Luiz Aldá JúniorMiguel Alves Gallo PereiraMapse Barroso Ferreira FilhoHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoVitor dos Santos SousaSandro Fonseca de SouzaJordan MartinsClemencia Mora HerreraKevin Mota AmariloLuiz MundimHelio NogimaAlberto SantoroSheila Mara Silva Do AmaralAndre SznajderMauricio ThielAntonio Vilela PereiraCesar Augusto BernardesLuigi CalligarisThiago TomeiEduardo de Moraes GregoresPedro G MercadanteSergio F NovaesSandra PadulaAleksandar AleksandrovGeorgy AntchevRoumyana HadjiiskaPlamen IaydjievMilena MishevaMircho RodozovMariana ShopovaGeorgi SultanovAnton DimitrovTodor IvanovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovElton ShumkaShalini ThakurTongguang ChengTahir JavaidMonika MittalLi YuanMuhammad AhmadGerry BauerZhen HuSamet LezkiKai YiGuo-Ming ChenHe-Sheng ChenMingshui ChenFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoZhenan LiuVukasin MilosevicFabio MontiRamkrishna SharmaJunquan TaoJoshuha Thomas-WilskerJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYing AnYong BanAndrew LevinCongqiao LiQiang LiXudong LyuYajun MaoSi-Jin QianXiaohu SunDayong WangJie XiaoHeng YangMeng LuZhengyun YouNan LuXuyang GaoDuncan LeggatHideki OkawaYu ZhangZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJhovanny Mejia GuisaoFelipe RamirezManuel RodriguezJosé David Ruiz AlvarezDuje GiljanovicNikola GodinovicDamir LelasIvica PuljakZeljko AntunovicMarko KovacToni SculacVuko 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KoJason Sang Hun LeeYunjae LeeJeremie Alexandre MerlinInkyu ParkYoun RohDonghyun SongIan WatsonSeungjin YangSeungkyu HaHwi Dong YooMinuk ChoiMi Ran KimHeewon LeeYonghoon LeeYounghoon LeeIntae YuTaha BeyrouthyYasser MaghrbiKarlis DreimanisGuntis PikursAndris PotrebkoMarkus SeidelViesturs VeckalnsMarijus AmbrozasAlexandra Carvalho Antunes de OliveiraAndrius JuodagalvisAurelijus RinkeviciusGintautas TamulaitisNurfikri Bin NorjoharuddeenSiew Yan HohImran YusuffZukhaimira ZolkapliJose F BenitezAlfredo Castaneda HernandezHedwin Aaron Encinas AcostaLuis Gabriel Gallegos MaríñezMoisés León CoelloJavier Alberto Murillo QuijadaAshish SehrawatLizardo Valencia PalomoGabriel AyalaHeriberto Castilla-ValdezIvan Heredia-De La CruzRicardo Lopez-FernandezCesar Atzin Mondragon HerreraDaniel Alejandro Perez NavarroAlberto Sánchez HernándezCristina Oropeza BarreraFabiola Vazquez ValenciaIsabel PedrazaHumberto Antonio Salazar IbarguenCecilia Uribe EstradaItana BubanjaJelena MijuskovicNatasa RaicevicAshfaq 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Résumé : Correlations between azimuthal anisotropy and mean transverse momentum of charged particles in proton-proton (pp), proton-lead (pPb), and peripheral lead-lead (PbPb) collisions are presented as a function of charged particle multiplicity. The pp, pPb and PbPb collision data were collected using the CMS detector at the LHC with a center-of-mass energy per nucleon pair of 13, 8.16 and 5.02 TeV, respectively. The two- and four-particle cumulants for the second- and third-order Fourier anisotropy harmonics are correlated with the mean transverse momentum of charged particles on an event-by-event basis. In pp and pPb systems, the observed correlation coefficients based on two-particle cumulants are found to change from negative to positive values as the charged particle multiplicity decreases. The sign changes disappear when the correlated particles are required to be further apart in pseudorapidity. Additionally, no sign changes in correlation coefficients are observed when employing four-particle cumulants. Models incorporating initial-state gluon saturation and final-state hydrodynamic evolutions are compared to pPb data and the predicted sign changes are not observed.

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