Thomas BOUCHER

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Lise CuzinClotilde AllavenaLaurent CotteCyrille DelpierreThomas HuleuxRomain PalichPierre DelobelFrançois RaffiAndré CabiéC Drobacheff-ThiébautA FoltzerKevin BouillerL Hustache- MathieuCatherine ChirouzeQ LepillerF BozonO BabreL BrunelP Muret (besançon)H LaurichesseO LesensM VidalN MrozekAumeran C.O BaudV CorbinP Letertre-GibertS CasanovaJ ProuteauC Jacomet (clermont Ferrand)I LamauryI FabreE CurlierR OuissaC Herrmann-StorckB TressieresT BonijolyM. ReceveurF BoulardC DanielC Clavel (guadeloupe)D MerrienP PerréT GuimardO BollangierS LeautezM MorrierL Laine (la Roche Sur Yon)F AderA BeckerF BironA BoibieuxT FerryP MiailhesT PerpointStéphane RouxC Triffault-FillitS DegroodtC BrochierF ValourC Chidiac (lyon)A MénardA. BelkhirP ColsonC DhiverA MadridM Martin-DegiovaniL MeddebM MokhtariA MotteA RaouxI RavauxC TamaletC ToméiH Tissot DupontS BrégigeonO Zaegel-FaucherV Obry-RoguetH LarocheM OrticoniM. SoaviP Geneau de LamarlièreE RessiotM. DucassouI JaquetS GalieA GalinierP MartinetM LandonA. RitlengA IvanovaC DebreuxC LionsI Poizot-Martin (marseille Ste Marguerite)B BigeardO CabrasK GuitteaudM IlliaquerA MarquiseS Pierre-FrançoisJ PasquierK RomeJ. TurmelC VaracheA Cabié (martinique)N AtouiM BistoquetE DelaporteV Le MoingAlain MakinsonN MeftahC Merle de BoeverB MontesA Montoya FerrerEdouard TuaillonJ Reynes (montpellier)M AndréL BoyerM. BouillonM DelestanC RabaudT MayB Hoen (nancy)C BernaudE BillaudC BironB BonnetS BouchezD BoutoilleC Brunet-CartierC DeschanvresB GabortiN HallT JovelinP MorineauV ReliquetS SécherM CavellecA SoriaV FerréE André-GarnierA RodallecM LefebvreO GrossiO AubryF Raffi (nantes)P PuglieseS BreaudC CeppiD ChirioE CuaP DellamonicaE DemonchyA de MonteJ DurantC EtienneS FerrandoR GarraffoC MichelangeliV MondainA NaqviN OranI PerbostS PilletC PradierB Prouvost-KellerK RissoV RioP. RogerE RosenthalS SausseI TouitouS Wehrlen-PuglieseG Zouzou (nice)L HocquelouxT PrazuckC GubavuA SèveA MakaC BoulardG ThomasElisabeth Botelho-NeversA Gagneux-BrunonA FrésardV RonatF LuchtP FischerM PartisaniC CheneauM PriesterM. BatardC Bernard-HenryE de MautortSamira Fafi-KremerD ReyM AlvarezN BiezunskiA DebardP LansalotL LelièvreG Martin-BlondelM PiffautL PorteK SauneF AjanaE AïssiI AlcarazV BacletL BocketA BoucherP ChoisyB Lafon-DesmursA MeybeckM PradierO RobineauN VigetM ValetteY YazdanpanahR LandmanC DuvivierM. ValantinR AgherC KatlamaP FlandreO LortholaryV Avettand-FenoelC RouziouxP. ConsignyG CessotF TouamR UsubillagaK BenhadjDrobacheff-Thiébaut CFoltzer ABouiller KHustache-Mathieu LChirouze CLepiller QBozon FBabre OBrunel LBesançon P MuretLaurichesse HLesens OVidal MMrozek NAumeran CBaud OCorbin VLetertre-Gibert PCasanova SProuteau JFerrand C Jacomet ClermontLamaury IFabre ICurlier EOuissa RHerrmann-Storck CTressieres BBonijoly TReceveur M CBoulard FDaniel CGuadeloupe C ClavelMerrien DPerré PGuimard TBollangier OLeautez SMorrier MYon L Laine La Roche SurAder FBecker ABiron FBoibieux ACotte LFerry TMiailhes PPerpoint TRoux STriffault-Fillit CDegroodt SBrochier CValour FLyon C ChidiacMénard ABelkhir a YColson PDhiver CMadrid AMartin-Degiovani MMeddeb LMokhtari MMotte ARaoux ARavaux ITamalet CToméi CDupont H TissotBrégigeon SZaegel-Faucher OObry-Roguet VLaroche HOrticoni MSoavi M JLamarlière P Geneau DeRessiot EDucassou M JJaquet IGalie SGalinier AMartinet PLandon MRitleng a SIvanova ADebreux CLions CMarguerite I Poizot-Martin Marseille SteBigeard BCabras OCuzin LGuitteaud KIlliaquer MMarquise APierre-François SPasquier JRome KTurmel J MVarache CMartinique a CabiéAtoui NBistoquet MDelaporte EMoing V LeMakinson AMeftah NBoever C Merle DeMontes BFerrer a MontoyaTuaillon EMontpellier J ReynesAndré MBoyer LBouillon M PDelestan MRabaud CMay TNancy B HoenAllavena CBernaud CBillaud EBiron CBonnet BBouchez SBoutoille DBrunet-Cartier CDeschanvres CGaborti BHall NJovelin TMorineau PReliquet VSécher SCavellec MSoria AFerré VAndré-Garnier ERodallec ALefebvre MGrossi OAubry ONantes F RaffiPugliese PBreaud SCeppi CChirio DCua EDellamonica PDemonchy EMonte a DeDurant JEtienne CFerrando SGarraffo RMichelangeli CMondain VNaqvi AOran NPerbost IPillet SPradier CProuvost-Keller BRisso KRio VRoger P MRosenthal ESausse STouitou IWehrlen-Pugliese SNice G ZouzouHocqueloux LPrazuck TGubavu CSève AMaka ABoulard CThomas GBotelho-Nevers EGagneux-Brunon AFrésard ARonat VLucht FFischer PPartisani MCheneau CPriester MBatard M LBernard-Henry CMautort E DeFafi-Kremer SRey DAlvarez MBiezunski NDebard ADelpierre CLansalot PLelièvre LMartin-Blondel GPiffaut MPorte LSaune KDelobel PAjana FAïssi EAlcaraz IBaclet VBocket LBoucher AChoisy PHuleux TLafon-Desmurs BMeybeck APradier MRobineau OViget NValette MYazdanpanah YLandman RDuvivier CValantin M AAgher RKatlama CFlandre PLortholary OAvettand-Fenoel VRouzioux CConsigny P HCessot GTouam FUsubillaga RBenhadj K
• Organismes : Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] Université Toulouse III - Paul Sabatier Centre Hospitalier de Tourcoing CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Service Maladies infectieuses et tropicales [CHU Toulouse] Centre de Physiopathologie Toulouse Purpan Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Centre d'Investigation Clinique Antilles-Guyane Laboratoire Chrono-environnement (UMR 6249) Centre Hospitalier Régional Universitaire de Besançon Laboratoire Chrono-environnement (UMR 6249) Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Régional Universitaire de Besançon Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) EDF - Division Technique Générale Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand] Laboratoire Microorganismes : Génome et Environnement Géoazur Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand] Laboratoire Microorganismes : Génome et Environnement Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Service Hygiène Hospitalière [CHU Clermont-Ferrand] Université Clermont Auvergne CHU Clermont-Ferrand CCLIN Sud-Est – Centre de Coordination de la Lutte contre les Infections Nosocomiales Sud-Est Service de Maladies Infectieuses et Tropicales Laboratoire Microorganismes : Génome et Environnement Henryk Niewodniczanski Institute of Nuclear Physics Service des maladies infectieuses et tropicales Dermatologie et Maladies infectieuses [Pointe-à-Pitre] Station de Recherche Agronomique de Saint Louis Centre Hospitalier Régional Universitaire [Montpellier] Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Centre Hospitalier Régional Universitaire [Montpellier] Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

---

Résumé : Objectives Even in an ‘optimal’ health system, patients’ characteristics may have an impact on their care. We investigated whether age, gender and place of birth have an impact in the HIV care continuum in France, a country with a universal free healthcare system. Methods We estimated differences in the 5 year restricted mean percentage of person-time spent (i) in care, (ii) receiving ART and (iii) on ART and virally suppressed among 2432 (30.2%) women, 3925 MSM (48.7%) and 1709 men who have sex with women (MSW; 21.2%) entering care in the Dat’AIDS French prospective cohort between 1 January 2013 and 31 December 2017. Trial registration: Clinicaltrials.gov reference NCT02898987. Results Men and women spent 85.6% and 82.8% of person-time on ART and 69.9% and 65% suppressed, respectively. MSM, MSW and women spent 86.9%, 82.6% and 82.8% of person-time on ART and 72.5%, 63.7% and 65% suppressed, respectively. Patients born in France (47%) and patients born abroad spent 87.9% and 81.9% of person-time on ART and 74.6% and 62.9% suppressed, respectively. Young men born abroad were found to spend the smallest person-time with non-detectable viral load (53% for MSW and 58.1% for MSM). Conclusions Despite free access to care and universal ART in France, disparities remain in the HIV continuum care across age, country of birth and way of HIV acquisition. Clinical and public health interventions targeting specific patients’ conditions are needed.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2021
• Auteurs : Jean-Yves BlayS. BoucherB. Le VuC. CropetS. ChabaudDavid PérolE. BarrangerMario CamponeT. ConroyCharles CoutantR. de CrevoisierA. Debreuve-TheresetteJean-Pierre DelordPierre FumoleauJ. GentilF. GomezO. GuerinA. JaffréE. LartigauC. LemoineM.A. MaheFrançois-Xavier MahonH. Mathieu-DaudeY. MerroucheFrédérique Penault-LlorcaX. PivotJ.C. SoriaG. ThomasP. VeraT. VermeulinP. ViensM. YchouS. Beaupere
• Organismes : Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand]
• Publié dans ESMO Open le 03/05/2021

---

Fichiers liés : S2059702921000934.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Bertrand ChesneauAurélie PlanckeGuillaume RollandNicolas ChassaingChristine CoubesElise Brischoux-BoucherThomas EdouardYves DulacMarion Aubert-MuccaThierry Lavabre-BertrandJulie PlaisanciéPhilippe KHAU VAN KIEN
• Organismes : Centre Hospitalier Universitaire de Nîmes Centre de Référence du Syndrome de Marfan et des maladies apparentées Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Service Génétique Médicale [CHU Toulouse] Département de génétique médicale, maladies rares et médecine personnalisée [CHU Montpellier] Centre de génétique humaine [CHRU Besançon] Centre de Référence du Syndrome de Marfan et des maladies apparentées Centre de Référence du Syndrome de Marfan et des maladies apparentées Centre de Référence du Syndrome de Marfan et des maladies apparentées Centre Hospitalier Universitaire de Nîmes Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] Centre de Référence du Syndrome de Marfan et des maladies apparentées Service Génétique Médicale [CHU Toulouse] Centre Hospitalier Universitaire de Nîmes
• Publié dans European Journal of Human Genetics le 22/10/2020

---

Résumé : Marfan syndrome (MFS) is a heritable connective tissue disorder (HCTD) caused by pathogenic variants in FBN1 that frequently occur de novo. Although individuals with somatogonadal mosaicisms have been reported with respect to MFS and other HCTD, the overall frequency of parental mosaicism in this pathology is unknown. In an attempt to estimate this frequency, we reviewed all the 333 patients with a disease-causing variant in FBN1 . We then used direct sequencing, combined with High Resolution Melting Analysis, to detect mosaicism in their parents, complemented by NGS when a mosaicism was objectivized. We found that (1) the number of apparently de novo events is much higher than the classically admitted number (around 50% of patients and not 25% as expected for FBN1 ) and (2) around 5% of the FBN1 disease-causing variants were not actually de novo as anticipated, but inherited in a context of somatogonadal mosaicisms revealed in parents from three families. High Resolution Melting Analysis and NGS were more efficient at detecting and evaluating the level of mosaicism compared to direct Sanger sequencing. We also investigated individuals with a causal variant in another gene identified through our “aortic diseases genes” NGS panel and report, for the first time, on an individual with a somatogonadal mosaicism in COL5A1 . Our study shows that parental mosaicism is not that rare in Marfan syndrome and should be investigated with appropriate methods given its implications in patient’s management.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 29/03/2021
• Auteurs : Thomas SauvaitreSandrine BrugirouxGwenaelle RocheCélia LedieuCaroline ChevarinCatherine GodfraindChristophe MassardKomla Oscar AwitorNicolas BarnichMathilde BonnetDelphine Boucher
• Organismes : Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte CHU Clermont-Ferrand Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2021
• Auteurs : J.C. BenitezM.E. BoucherE. DansinM. KerjouanL. Bigay-GameE. PichonF. ThillaysPierre-Emmanuel FalcozS. LyubimovaY. OulkhouirF. CalcagnoL. ThibervilleC. Clément-DuchêneF. MorinP. MissyP.A. ThomasJ. MauryT. MolinaN. GirardB. Besse
• Organismes : Institut Gustave Roussy Institut Gustave Roussy Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Toulouse Hôpital Bretonneau Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Hospitalier Universitaire [Strasbourg] CHU Montpellier = Montpellier University Hospital CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Régional Universitaire de Besançon CHU Rouen Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Intergroupe Francophone de Cancérologie Thoracique [Paris] Intergroupe Francophone de Cancérologie Thoracique [Paris] Hôpital Nord [CHU - APHM] Institut Curie [Paris] Université Claude Bernard Lyon 1 Hôpital Necker - Enfants Malades [AP-HP] Institut Curie [Paris] Institut Gustave Roussy Département de médecine oncologique [Gustave Roussy]
• Publié dans Journal of Thoracic Oncology le 31/10/2020

---

Résumé : Introduction TET are rare malignancies, with an annual incidence of 350 cases in France. The main prognostic factors are Masaoka-koga stage and quality of the resection. However, no large cohorts have been published concerning resection outcomes. RYTHMIC (Réseau tumeurs THYMiques et Cancer) is a French network mandated to systematically discuss every case of TET. We aimed to describe the resected tumor outcomes in a large French population. Methods RYTHMIC database, hosted by IFCT (Intergroupe Francophone de Cancérologie Thoracique), prospectively includes all consecutive pts with a diagnosis of TET discussed in French national or regional tumor boards. We analyzed epidemiologic, clinical and pathological characteristics of 1045 pts operated of a TET. Results From January 2012 to December 2019, 2909 pts were included in the database. Overall, the median age at diagnosis of TET was 60 (range 9-90) and 52% (n=1513) were male. Of them, 1082 (37,2%) pts were operated. 304/1045 (29%) pts reported autoimmune disorders and Myasthenia Gravis was the most common (250 pts, 82,2%). Masaoka-Koga stages (MK) were well balanced with 23% (n=240) stage I, 17.2% (n=180) stage IIa, 18.2% (n=190) stage IIb, 19.6% (n=205) stage III with lung as a main invaded organ (37%), 8% (n=85) stage IVa and 4.9% (n=51) stage IVb. Among resected tumors, B2 and AB were the most common subtypes (n=247, 23.6% and n=237, 22.7% respectively). Sternotomy was the most used approach for resection (n=735, 70.3%). In addition to TET, surgery was extended to lung (35%), pericardium (24%), pleura (13%), recurrent nerve or great vessels (10%) and lymph nodes (46%). Complete resection was assessed in 71% of procedures with a median tumor size of 55mm (1-260) and a range of 0-28 resected pleural metastasis. Intrapleural chemotherapy was used as an associated technique during the first-line surgery (6/17 pts) or after recurrence (9/17 pts, 53%) shrinking the hazard for progression (PD) (OR= 0.5 95%CI [0.29 to 0.84], p<0.00). Induction chemotherapy and adjuvant radiotherapy was administered in 119/182 (65,3%) and 357/1045 (34.2%) pts, respectively. Principal location for progression was the pleura (119/223 pts, 53%) with surgery as the main treatment (31%). Median-OS was 263 months (95%CI[NotR-NotR]) and median-PFS was 111 months (95%CI[97,4-124,5]). The Cox proportional Hazard’s model showed a statistically significant greater risk for PD of MK III comparing with other localized tumors (HR=10,618 95%CI[1,172-96,224], p=0,036). Patients presenting thymoma B3 and epidermoid thymic carcinoma assessed risk for PD (HR=1,357 95%[0,531-3,462]; p=0,524 and HR= 1,982 95%CI[0,774-5,073]; p=0,154, respectively). Patients who needed lung or phrenic nerve resection showed higher risk for PD (HR=1,643 95%CI[1,181-2,286]; p=0,003 and HR=1,829 95%CI[1,217-2,748]; p=0,003, respectively). Bigger tumors and those with no complete resection (R1) were more likely to progress (HR=1,009 95%CI[1,004-1,013]; p<0,00 and HR=1,821 95%CI[1,058-3,133]; p=0,03, respectively). Conclusion Up to 37% of RYTHMIC cohort were resected. MK I and III were the most common resected tumors with 71% of complete resection with impact on survival. Thymic carcinoma and thymoma B3 were more likely to progress. Pleura was the main site for recurrence and surgery the most used treatment, in addition with intrapleural chemotherapy in some cases.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 05/01/2021
• Auteurs : Pierre PradatCatherine ChirouzeC Drobacheff-ThiébautA FoltzerKevin BouillerL Hustache-MathieuQ LepillerF BozonO BabreA BrunelP MuretE ChevalierC JacometH LaurichesseO LesensM VidalN MrozekAumeran C.O BaudV CorbinE GoncalvezA MirandA BrebionC HenquellI LamauryI FabreE CurlierR OuissaC Herrmann-StorckB TressieresM ReceveurF BoulardC DanielC ClavelP RogerS MarkowiczN Chellum RungenD MerrienP PerréT GuimardO BollangierS LeautezM MorrierL LaineD BoucherP PointLaurent CotteF AderA BeckerA BoibieuxC BrochierF Brunel-DalmasO CannessonP ChiarelloC ChidiacS DegroodtT FerryM GodinotJ LivrozetD MakhloufiP MiailhesT PerpointM PerryC PouderouxStéphane RouxC Triffault-FillitF ValourC CharreV IcardJ TardyM TrabaudI RavauxA MénardA BelkhirP ColsonC DhiverA MadridM Martin-DegioanniL MeddebM MokhtariA MotteA RaouxC ToméiH Tissot-DupontIsabelle Poizot-MartinS BrégigeonO Zaegel-FaucherV Obry-RoguetH LarocheM OrticoniM SoaviE RessiotM DucassouI JaquetS GalieH ColsonA RitlengA IvanovaC DebreuxC LionsT Rojas-RojasAndré CabiéS AbelJ BavayB BigeardO CabrasL CuzinR Dupin de MajoubertL FagourK GuitteaudA MarquiseF NajioullahS Pierre-FrançoisJ PasquierP RichardK RomeJ TurmelC VaracheN AtouiM BistoquetE DelaporteV Le MoingAlain MakinsonN MeftahC Merle de BoeverB MontesA Montoya FerrerE TuaillonJ ReynesB LefèvreE JeanmaireS HénardE FrentiuA CharmillonA LegoffN TissotM AndréL BoyerM BouillonM DelestanF GoehringerS BevilacquaC RabaudT MayF RaffiC AllavenaO AubryE BillaudC BironB BonnetS BouchezD BoutoilleC Brunet-CartierC DeschanvresB GaboritA GrégoireM GrégoireO GrossiR GuéryMaeva LefebvreP Le TurnierR LecomteP MorineauV ReliquetS SécherM CavellecE ParedesA SoriaV FerréE André-GarnierA RodallecPascal PuglieseS BreaudC CeppiD ChirioE CuaP DellamonicaE DemonchyA de MonteJ DurantC EtienneS FerrandoR GarraffoC MichelangeliV MondainA NaqviN OranI PerbostM CarlesC KlotzA MakaC PradierB Prouvost-KellerK RissoV RioE RosenthalI TouitouS Wehrlen-PuglieseG ZouzouLaurent HocquelouxT PrazuckC GubavuA SèveS GiachéV RzepeckiM ColinC BoulardG ThomasA CheretC GoujardY QuertainmontE TeicherN LerolleS JaureguiberryR ColarinoO DeradjiA CastroA Barrail-TranY YazdanpanahR LandmanV JolyJ GhosnC RiouxS LarivenA GervaisF LescureS MatheronF LouniZ JuliaS Le GacC CharpentierD DescampsG PeytavinC DuvivierC AguilarF Alby-LaurentK AmazzoughG BenabdelmoumenP BossiG CessotC CharlierP ConsignyK JidarE LafontF LanternierJ LeporrierO LortholaryC LouisinJ LourencoP ParizeB PilmisC RouzaudF TouamM ValantinR TubianaR AgherSophie SeangL SchneiderR PalichC BlancC KatlamaFirouze Bani-SadrJ BergerY N’guyenD LambertI KmiecM HentzienA BrunetJ RomaruH MartyV BrodardC ArvieuxP TattevinM RevestF SoualaM BaldeyrouS Patrat-DelonJ ChapplainF BenezitMaeva DupontM PoinotA MaillardC PronierFlorian LemaitreC MorlatM Poisson-VannierT JovelinJ SinteffA Gagneux-BrunonElisabeth Botelho-NeversA FrésardV RonatF LuchtDavid ReyP FischerM PartisaniC CheneauM PriesterC MélounouC Bernard-HenryE de MautortSamira Fafi-KremerPierre DelobelM AlvarezN BiezunskiA DebardCyrille DelpierreG GaubeP LansalotL LelièvreM MarcelG Martin-BlondelM PiffautL PorteK SauneO RobineauF AjanaE AïssiI AlcarazE AlidjinouV BacletL BocketA BoucherM DigumberThomas HuleuxB Lafon-DesmursA MeybeckM PradierM TetartP ThillN VigetM Valette
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Clinical Infectious Diseases le 30/10/2020

---

Résumé : Abstract Background The arrival of highly effective, well-tolerated, direct-acting antiviral agents (DAA) led to a dramatic decrease in hepatitis C virus (HCV) prevalence. Human immunodeficiency virus (HIV)-HCV–coinfected patients are deemed a priority population for HCV elimination, while a rise in recently acquired HCV infections in men who have sex with men (MSM) has been described. We describe the variations in HIV-HCV epidemiology in the French Dat’AIDS cohort. Methods This was a retrospective analysis of a prospective cohort of persons living with HIV (PLWH) from 2012 to 2018. We determined HCV prevalence, HCV incidence, proportion of viremic patients, treatment uptake, and mortality rate in the full cohort and by HIV risk factors. Results From 2012 to 2018, 50 861 PLWH with a known HCV status were followed up. During the period, HCV prevalence decreased from 15.4% to 13.5%. HCV prevalence among new HIV cases increased from 1.9% to 3.5% in MSM but remained stable in other groups. Recently acquired HCV incidence increased from 0.36/100 person-years to 1.25/100 person-years in MSM. The proportion of viremic patients decreased from 67.0% to 8.9%. MSM became the first group of viremic patients in 2018 (37.9%). Recently acquired hepatitis represented 59.2% of viremic MSM in 2018. DAA treatment uptake increased from 11.4% to 61.5%. More treatments were initiated in MSM in 2018 (41.2%) than in intravenous drug users (35.6%). In MSM, treatment at the acute phase represented 30.0% of treatments in 2018. Conclusions A major shift in HCV epidemiology was observed in PLWH in France from 2012 to 2018, leading to a unique situation in which the major group of HCV transmission in 2018 was MSM. Clinical Trials Registration. NCT02898987.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : James GlasbeyDmitri NepogodievJoana F.F. SimoesOmar OmarElizabeth LiMary VennMohammad Abou ChaarVita CapizziDaoud ChaudhryAnant DesaiJonathan EdwardsJonathan EvansMarco FioreJose Flavio VideriaSamuel FordIan GanlyEwen GriffithsRohan GujjuriAngelos KoliasHaytham M.A. KaafaraniAna Minaya-BravoSiobhan MckayHelen MohanKeith RobertsCarlos San Miguel-MéndezPeter PockneyRichard ShawNeil SmartGrant StewartSudha Sundar, MrcogRaghavan VidyaAneel BhanguJames GlasbeyDmitri NepogodievJoana Ff SimoesOmar OmarElizabeth LiMary VennMohammad Abou ChaarVita CapizziDaoud ChaudhryAnant DesaiJonathan EdwardsJonathan EvansMarco FioreJose Flavio VideriaSamuel FordIan GanyliEwen GriffithsRohan GujjuriAngelos KoliasHaytham Ma KaafaraniAna Minaya-BravoSiobhan MckayHelen MohanKeith RobertsCarlos San Miguel-MéndezPeter PockneyRichard ShawNeil SmartGrant StewartSudha SundarRaghavan VidyaAneel BhanguJames GlasbeyOmar OmarAneel BhanguKwabena Siaw-AcheampongRuth BensonEdward BywaterDaoud ChaudhryBrett DawsonJonathan EvansJames GlasbeyRohan GujjuriEmily HeritageConor JonesSivesh KamarajahChetan KhatriRachel KhawJames KeatleyAndrew KnightSamuel LawdayElizabeth LiHarvinder MannElla MarsonKenneth McleanSiobhan MckayEmily MillsDmitri NepogodievGianluca PellinoMaria PicciochiElliott TaylorAbhinav TiwariJoana Ff SimoesIsobel TroutMary VennRichard Jw WilkinAneel BhanguJames GlasbeyNeil SmartAna Minaya-BravoJonathan EvansGaetano GalloSusan MougFrancesco PataPeter PockneySalomone Di SaverioAbigail VallanceDale VimalchandranEwen GriffithsSivesh KamarajahRichard Pt EvansPhilip TownendKeith RobertsSiobhan MckayJohn IsaacSohei SatoiJohn EdwardsAman CoonarAdrian MarchbankEdward CaruanaGeorgia LaytonAkshay PatelAlessandro BrunelliSamuel FordAnant DesaiAlessandro GronchiMarco FioreMax AlmondFabio TirottaSinziana DumitraAngelos KoliasStephen PriceDaniel FountainMichael JenkinsonPeter HutchinsonHani MarcusRory PiperLaura LippaFranco ServadeiIgnatius EseneChristian FreyschlagIuri NevilleGail RosseauKarl SchallerAndreas DemetriadesFaith RobertsonAlex AlamriRichard ShawAndrew SchacheStuart WinterMichael HoPaul NankivellJuan Rey BielMartin BatstoneIan GanlyRaghavan VidyaAlex WilkinsJagdeep SinghDinesh ThekinkattilSudha SundarChristina FotopoulouElaine LeungTabassum KhanLuis ChivaJalid SehouliAnna FagottiPaul CohenMurat GutelkinRahel GhebreThomas KonneyRene ParejaRob BristowSean DowdyTs ShylasreeR Kottayasamy SeenivasagamJoe NgKeiiji FujiwaraGrant StewartBenjamin LambKrishna NarahariAlan McneillAlexandra ColquhounJohn McgrathSteve BromageRavi BarodVeeru KasivisvanathanTobias KlatteJoana Ff SimoesTom Ef AbbottSadi AbukhalafMichel AdaminaAdesoji AdemuyiwaArnav AgarwalMurat AkkulakEhab AlameerDerek AldersonFelix AlakalokoMarkus AlbertsmeiersOsaid AlserMuhammad AlshaarSattar AlshrydaAlexis ArnaudKnut Magne AugestadFaris AyasraJosé AzevedoBrittany Bankhead-KendallEmma BarlowDavid BeardRuth BensonRuth Blanco-ColinoAmanpreet BrarAna Minaya-BravoKerry BreenChris BrethertonIgor Lima BuarqueJoshua BurkeEdward CaruanaMohammad ChaarSohini ChakraborteePeter ChristensenDaniel CoxMoises CukierMiguel CunhaGiana DavidsonAnant DesaiSalomone Di SaverioThomas DrakeJohn EdwardsMuhammed ElhadiSameh EmileShebani FarikMarco FioreJ Edward FitzgeraldSamuel FordTatiana GarmanovaGaetano GalloDhruv GhoshGustavo Mendonça Ataíde GomesGustavo GrecinosEwen GriffithsMadalegna GründlConstantine HalkiasEwen HarrisonIntisar HishamPeter HutchinsonShelley HwangArda IsikMichael JenkinsonPascal JonkerHaytham Ma KaafaraniDebby KellerAngelos KoliasSchelto KruijffIsmail LawaniHans LederhuberSezai LeventogluAndrey LitvinAndrew LoehrerMarkus LöfflerMaria Aguilera LorenaMaria Marta ModoloPiotr MajorJanet MartinHassan MashbariDennis MazingiSymeon MetallidisAna Minaya-BravoHelen MohanRachel MooreDavid MoszkowiczSusan MougJoshua Ng-KamstraMayaba MaimboIonut NegoiMilagros NiquenFaustin NtirenganyaMaricarmen OlivosKacimi OussamaOumaima OutaniMarie Dione Parreno-SacdalanmFrancesco PataCarlos Jose Perez RiveraThomas PinkneyWillemijn van der PlasPeter PockneyAhmad QureshiDejan RadenkovicAntonio Ramos-de la MedinaKeith RobertsApril RoslaniMartin RutegårdJuan José Segura-SampedroIrène SantosSohei SatoiRaza SayyedAndrew SchacheAndreas SchnitzbauerJustina Seyi-OlajideNeil SharmaRichard ShawSebastian ShuKjetil SoreideAntonino SpinelliGrant StewartMalin SundSudha SundarStephen TabiriPhilip TownendGeorgios TsoulfasGabrielle van RamshorstRaghavan VidyaDale VimalachandranOliver WarrenDuane WedderburnNaomi WrightC AllemandL BoccalatteM FigariM LammJ LarrañagaC MarchitelliF NollD OdettoM PerrottaJ SaadiL ZamoraC AlurraldeEl CaramD EskinaziJp MendozaM UsandivarasR BadraA EstebanJs GarcíaPm GarcíaJi GerchunoffSm LucchiniMa NigraL VargasT HovhannisyanA StepanyanT GouldR GourlayB GriffithsS GananadhaM MclarenJ CecireN JoshiS SalinderaA SutherlandJh AhnG CharltonS ChenN GauriR HayhurstS JangF JiaC MulliganW YangG YeH ZhangM BallalD GibsonD HayneJ MossT RichardsP ViswambaramUg VoJ BennettsT BrightM Brooke-SmithR FongB GricksYh LamBs OngM SzpytmaD WatsonK BagraithS CairdE ChanC DawsonD HoE JeyarajanS JordanA LimGj NolanA OarD ParkerH PuhallaA QuennellL RutherfordP TownendM von PapenM WullschlegerA BlattD CopeN EgoroffM FentonJ GaniN LottP PockneyN ShuggM ElliottD PhungD PhanD TownendC BongJ GundaraA FrankelS BowmanGr GuerraJ BoltK BuddinghNn Dudi-VenkataS JogHm KroonT SammourR SmithC StranzM BatstoneK LahW McgahanD MitchellA MortonA PearceM RobertsG SheahanB SwinsonN AlamS BantingL ChongP ChoongS ClatworthyD FoleyA FoxMw HiiB KnowlesJ MackM ReadA RowcroftS WardG WrightM LannerI KönigsrainerM BauerC FreyschlagM KafkaF MessnerD ÖfnerI TsibulakK EmmanuelM GrechenigR GruberM HaraldL ÖhlbergerJ PreslA Wimmerİ NamazovE SamadovD BarkerR BoyceS CorbinA DoyleA EastmondR GillA HaynesS MillarM O’sheaG PadmoreN PaquetteE PhillipsS St. JohnK WalkesN FlameyP PattynW OosterlinckJ van den EyndeR van den EyndeA GattiC NardiR OlivaR de CiccoI CecconelloP GregorioL Pontual LimaU Ribeiro JuniorF TakedaRm TerraM SokolovB KidaneS SrinathanM BoutrosN CaminskyG GhitulescuG JamjoumJ MoonJ PelletierT VanounouS WongM BoutrosS DumitraA KouyoumdjianB JohnstonC RussellM BoutrosS DemyttenaereR GarfinkleJ Abou-KhalilC NessimJ StevensonF HerediaA AlmecigaA FletcherA MerchanLo PuentesJ Mendoza QuevedoG BačićD KarlovićD KršulM ZelićI LuksicM MamicB BakmazI ĆozaE DijanZ KatusicJ MihanovicI RakvinK FrantzeskouN GouvasG KokkinosP PapatheodorouI PozotouO StavrinidouA YiallourouL MartinekM SkrovinaI SzubotaJ ŽateckýV JavurkovaJ KlatT AvlundP ChristensenJl HarbjergLh IversenDw KjaerHø KristensenM MekhaelAl EbbehøjP KrarupN SchlesingerH SmithA AbdelsamedAy AzzamH SalemA SeleimA AbdelmajeedM AbdouNe AbosamakM Al SayedF AshoushR AttaE ElazzazyM ElhoseinyM ElnemrMs ElqasabiMe Elsayed HewallaI ElsherbiniE EssamM EwedaI GhallabE HassanM IbrahimM MetwalliM MouradMs QatoraM RagabA SabryH SaifeldinM Saleh Mesbah Mohamed ElkaffasA SamihA Samir AbdelaalS ShehataK ShenitDina AttiaN KamalN OsmanAm AbbasHas Abd ElazeemMm AbdelkaremS AlaaAk AliA AymanMg AzizeldineH ElkhayatS M.ElghazalyFa MonibMa NagehMm SaadM SalahM ShahineEa YousofA YoussefA EldalyM ElfikyA NabilG AmiraI SallamM SheriefA SherifA AbdelrahmanH AboulkassemG GhalyR HamdyA MorsiH SalemG SherifH AbdeldayemI Abdelkader SalamaM BalabelY FayedAe SherifD BekeleJ KauppilaE SarjanojaO HelminenH HuhtaJh KauppilaC BeyrneL JouffretL LugansL Marie-MacronE ChouillardB de SimoneJ BettoniStéphanie DakpéBernard DevauchelleN LavagenSylvie TestelinS BoucherR BreheretA GueutierA KahnJ Kün-DarboisA BarrabeZ LakkisA LouvrierS ManfredelliP MathieuA ChebaroV DrubayM El AmraniC EvenoK LecolleG LegaultL MartinG PiessenFr PruvotS TruantP ZerbibQ BallouheyB BarratJ LalozeH SalleA TaibiJ UsseglioD BergeatA MerdrignacRoy LeLo PerottoA ScalabreA AiméA EzannoB MalgrasP BoucheS TzedakisE CotteOlivier GlehenV KepenekianJ LifanteG PassotA D’ursoE FelliD MutterP PessauxB SeeligerJ BardetR BerryG BoddaertS BonnetE BrianC DenetD. FuksD GossotM GrigoroiuA LaforestY Levy-ZaubermanC Louis-SylvestreA MoumenG PourcherA Seguin-GiveletE TribillonE DuchalaisF EspitalierC FerronO MalardU BorkM DistlerJ FritzmannJ KirchbergC PraetoriusC RiedigerJ WeitzT WelschP WimbergerK BeyerC KamphuesJ LauscherFn LochC SchineisM AlbertsmeierM AngeleA KappenbergerH NiessT SchiergensJ WernerR BeckerJ JonescheitI PergoliniD ReimC BoekerI HakamiJ MallP LiokatisW SmolkaK NowakT ReinhardF HölzleA ModabberP WinnandM KnitschkeP KauffmannS WolferJ KleeffK LorenzC MichalskiU RonellenfitschR SchneiderE BertolaniA KönigsrainerMw LöfflerM QuanteC SteidleL ÜberrückC YurttasCs BetzJ BewarderA BöttcherS BurgC BuschM GosauA HeuerJ IzbickiTo KlatteD KoenigN MoeckelmannC NitschkeM PriemelR SmeetsU SpethS TholeFg UzunogluT VollkommerN ZellerMj BattistaK GillenA HasenburgS KrajnakV LinzR SchwabK AngelouD HaidopoulosA RodolakisP AntonakisK BramisL ChardaliasI ContisN DafniosD DellaportasG FragulidisA GklavasM KonstadoulakisN MemosI PapaconstantinouA PolydorouT TheodosopoulosA VezakisMi AntonopoulouDk ManatakisN TasisN ArkadopoulosN DaniasP EconomopoulouP KokoropoulosA LarentzakisN MichalopoulosJ SelmaniT SidiropoulosV TsaousisP VassiliuK BouchagierS KlimopoulosD PaspaliariG StylianidisK BaxevanidouK BouliarisP ChatzikomnitsaM EfthimiouA GiaglarasC KalfountzosG KoukoulisAm NtziovaraK PetropoulosK SoulikiaI TsiamalouK ZervasS ZourntouI BaloyiannisA DiamantisE GkriniaJ HajiioannouC KoraisO KoukouraK PerivoliotisA SaratziotisC SkoulakisD SymeonidisK TepetesG TzovarasD ZacharoulisV AlexoudiK AntoniadesI AstreidisP ChristidisD DeligiannidisT GrivasO IoannidisI KalaitsidouL LoutzidouA MantevasD MichailidouK ParaskevopoulosS PolitisA StavroglouD TatsisI TilaveridisK VahtsevanosG VenetisI KaraitianosT TsirlisA CharalabopoulosT LiakakosE MpailiD SchizasE SpartalisA SyllaiosC ZografosC AnthoulakisC ChristouV PapadopoulosA ToouliasD TsolakidisG TsoulfasD ZouzoulasE AthanasakisE ChrysosJ TsiaoussisS XenakiE XynosK FutabaMf HoSf HonTwc MakSsm NgCc FooB BankyN SusztákM AremuA Canas-MartinezO CullivanC MurphyP OwensL PickettL AkmenkalneJ ByrneM CorriganC CullinaneA DalyC FlemingP JordanS KilleenN LynchA MccarthyH MustafaS O’brienP O’learyWas SyedL VernonD CallananL HuangA IonescuP SheahanI BalasubramanianM BolandK ConlonD EvoyN FearonT GallagherJ GeraghtyH HeneghanN KennedyD MaguireD MccartanEw McdermottRs PrichardD WinterD AlazawiC BarryT BoyleW ButtEm ConnollyN DonlonC DonohueBa FaheyR FarrellC FitzgeraldJ KinsellaJo LarkinP LennonPj MaguireP MccormickBj MehiganH MohanT NugentH O’sullivanN RaviJv ReynoldsA RogersP ShokuhiJ SmithLa SmithC TimonY BashirG BassT ConnellyB CreavinH EarleyJa ElliottA GillisD KavanaghP NearyJ O’riordanIs ReynoldsD RiceP RidgwayM UmairM WhelanP CarrollC CollinsK CorlessL FinneganA FowlerA HoganM KerinA LoweryP McanenaK MckevittK NizamiÉ RyanA SamyJc CoffeyR CunninghamM DevineD NallyC PeirceS TormeyN HardyP NearyS O’malleyM RyanS MacinaNm MarianiE OpocherA Pisani CerettiF FerrariF OdicinoE SartoriC CotsoglouS GranieriF BiancoA Camillo’M ColledanS TorneseMf ZambelliG BissolottiS FusettiF LemmaMv MarinoA MirabellaG VaccarellaC AgostiniG AlemannoI BartoliniC BergaminiA BruscinoC CheccucciR de VincentiA Di BellaM FambriniL FortunaG MaltintiP MuiesanF PetragliaP ProsperiMn RingressiM RisalitiF SorbiA TaddeiR TucciC BassiL BortolasiT CampagnaroL CasettiM de PastenaA EspositoM FontanaA GuglielmiL LandoniG MalleoG MarchegianiS NobileS PaiellaC PedrazzaniS RattizzatoA RuzzenenteR SalviaG TurriM TuveriP BelloraG D’aloisioM FerrariE FranconeS GentilliH NikajM BianchiniM ChiarugiF CoccoliniG Di FrancoN FurbettaD GianardiS GuadagniL MorelliM PalmeriD TartagliaG AnaniaP CarcoforoM ChiozzaA de TroiaM Koleva RadicaM PortinariMg SibillaA UrbaniN FabbriCv FeoS GennariS PariniE RighiniL AmpolliniL BellantiM BergonzaniG BertoliG BocchialiniG D’angeloD LanfrancoL MusiniT PoliGp SantoroA VarazzaniL AguzzoliG BorgonovoC Castro RuizS CoiroG FalcoVd MandatoV MastrofilippoMt MontellaV AnnessiM ZizzoU GrossiS NovelloM RomanoS RossiG ZanusG EspositoF FrongiaA PisanuM PoddaC BellucoA LaurettaG MontoriL MorasM OlivieriF BussuAg CartaMl CossuP CottuA FancelluCf FeoGc GinesuG GiulianiM MadoniaT PerraA PirasA PorcuD RizzoAm ScanuA TeddeM TeddeP DelrioD RegaG BadalamentiG CampisiA CordovaM FranzaG ManiaciG RinaldiF ToiaM CalabròF FarnesiEg LunghiA MuratoreNs Pipitone FedericoF BàmbinaG D’andreaP FamiliariV PicottiG de PalmaG LuglioG PaganoFp TropeanoL BaldariGa BeltraminiL BoniE CassinottiA Gianni’L PignataroS TorrettaC AbatiniM BaiaD BiasoniG BoganiP CadenelliV CapizziSpb CioffiD CitterioLv CominiM CosimelliM FioreS FolliM GennaroL GianniniA GronchiM GuaglioA MacchiF MartinelliV MazzaferroA MoscaS PasqualiC PiazzaF RaspagliesiL RolliR SalvioniG SarpietroC SarreL SorrentinoA AgnesS AlfieriF BeliaA BiondiV CozzaA D’amoreD D’ugoV de SimoneA FagottiG GaspariniL GordiniF LittaCp LombardiL LorenzonAa MarraF MarziA MoroA ParelloE PerroneR PersianiC RattoF RosaG SaponaroG ScambiaO ScrimaG SgangaR TudiscoA BelliV GranataF IzzoR PalaiaR PatroneFm CarranoMm CarvelloA de VirgilioF Di CandidoF FerreliF GainoG MercanteV RossiA SpinelliG SprianoDm DonatiT FrisoniE PalmeriniA AprileF BarraP BatistottiS FerreroP FregattiS ScabiniM SparavignaE AstiD BernardiL BonavinaA LoveceL AdamoliM AnsarinS CenciarelliF ChuR de BerardinisU Fumagalli RomarioF MastrilliG PietrobonM TagliabueE BadellinoA FerreroR MassobrioA de Manzoni GarberiniP FedericoP MaidaE MarraG MarteA PetrilloT TammaroA TufoM BerselliG BorroniE CocozzaL ContiM DesioL LivraghiV QuintodeiA RizziA ZulloC BaldiC CorbelliniGm SampietroP CellerinoE BaldiniP CapelliL ContiSm IsolaniM RibollaA BondurriF ColomboL FerrarioC GuerciA MaffioliT ArmaoM BallabioP BisagniA GaglianoM LonghiM MadoniniP PizzicniAm BaiettiM BiasiniP MaremontiF NeriGm PrucherS RicciF RuggieroAg ZarabiniR BarmasseS MochetL MorelliA UsaiF BiancoP IncollingoS ManciniL Marino CosentinoA SagnottaR FruscioT GrassiLc NespoliN TaminiA AnastasiB BartalucciA BellacciG CanonicoL CapezzuoliC Di MartinoP IpponiC LinariM MontelaticiT NelliG SpagniL TirloniA VitaliE AbateM CasatiT CasiraghiL LafaceM SchiavoA ArminioA CotoiaV LizziF VovolaR VergariS D’ugoN DepalmaMg SpampinatoP BartolucciG BrachiniP BruzzanitiA ChiappiniV ChiarellaF CiccaronePm CicerchiaB CirilloG de TomaA Di BartolomeoE FioriGb FonsiG FrancoA FratiM GiuglianoI IannoneF La TorreP LapollaC LeonardoG MarruzzoS MeneghiniA MingoliD RibuffoM SalvatiA SantoroP SapienzaAk ScafaL SimonelliM ZambonGt CapolupoF CarannanteM CaricatoG MascianàE MazzottaA GattolinM MiglioreR RimondaD SasiaE TravaglioM CervelleraA GoriL SartarelliV ToniniM GiacomettiS ZontaA ChessaA FioriniC NorciniG CollettiM ConfalonieriA CostanziC FrattaruoloG MariM MonteleoneA BandieraL BoccioloneG BonavinaM CandianiG CandottiP de NardiF GagliardiM MedoneP MortiniG NegriP PariseM PiloniP SileriA VignaliA BelvedereP BernanteP BertoglioS BoussedraE BrunocillaR CiprianiG CisterninoE de CrescenzoP de IacoG DondiF FrioE JovineF Mineo BianchiJ NeriD ParlantiAm PerroneAp PezzutoM PignattiV PintoG PoggioliM RavaioliM RottoliR SchiavinaM SerenariM SerraP SolliM TaffurelliM TanzanuM TeseiT ViolanteS ZanottiF BorghiD CianfloccaS Di Maria GrimaldiD DonatiE GelardaP GerettoG GiraudoMc GiuffridaA MaranoS PalagiL PellegrinoC PelusoV TestaF AgrestaD PrandoM ZeseF AquilaC GambaccianiL LippaF PieriOs SantonocitoG ArmaturaG BertelliA FrenaP MarinelloF NotteS PataunerG ScottonSf FulginitiG GalloG SammarcoG VescioP BalerciaL CatarziG ConsortiF Di MarzoT FontanaH DaikoM IshikawaK IshiyamaS IwataK KanematsuY KanemitsuT KatoA KawaiE KobayashiM Kobayashi KatoK MoritaniF NakataniJ OgumaY TanaseM UnoM Al AbdallahF AyasraY AyasraA QasemFj Abu Za’nounehT FahmaweeA HmedatA IbrahimK ObeidatS Abdel AlR Abdel JalilMk Abou ChaarM Al-MasriH Al-NajjarF AlawnehO AlsarairehM ElayyanR GhanemI LataifehGz AlkadeekiFs Al MaadanyN AldokaliO SenossiMt SubhiD BurganE KamokaAi KilaniA SalamahM SalemA ShuwayyahE AbdulwahedE AlshareeaN AribiS AribiM BialaR GhamghM MorgomZ AldayriI EllojliA KredanS BradulskisE DainiusE KubiliuteJ KutkevičiusA ParseliunasA SubociusD VenskutonisF RasoaherinomenjanaharyJb RazafindrahitaLh SamisonEc OngKh HamdanMr IbrahimJa TanMr ThanapalN Amin SahidF HayatiJ JayasilanRk SriramS SubramaniamA Che JusohAh HussainAs Mohamed SidekMf Mohd YunusJy SohMpk WongAd ZakariaZ ZakariaA FadzliNq FathiPs KohYt LiewAc RoslaniCy TangLy TeohWj WongAs YahayaMr AlvarezR ArrangoizF CorderaMa de la Rosa AbaroaA Gómez-PedrazaR HernandezA Maffuz-AzizJa PosadaFc Becerra GarcíaA Alfaro-GoldaracenaGa BuerbaRa Castillejos-MolinaC ChanI Dominguez-RosadoH Medina-FrancoMá MercadoM Oropeza-AguilarE Peña Gómez PortugalOe Posadas-TrujilloF Rodriguez-CovarrubiasN Salgado-NesmeC SarreM VilatobaY ArkhaH BechriA El OuahabiMy OudrhiriF Derkaoui HassaniN El AbbadiL AmraniZh BelkhadirA BenkabbouO ChakibB El AhmadiY El BouaziziH EssangriA GhannamAm MajbarR MohsineA SouadkaR HompesEm Meima-van PraagAjm PronkS SharabianyB GrotenhuisL HartveldS ReijersW van HoudtJ BaaijM Bolster-van EenennaamM de GraaffD SloothaakP van DuijvendijkL Posma-BoumanT DerksenJ FrankenS OosterlingR de BreeJ KonstenM van HeinsbergenL FidelisTt SholadoyeMa TolaniJ OlaogunIk EgbuchulemTa LawalO OgundoyinDi OlulanaL Abdur-RahmanA AdeyeyeI AremuJ BelloO OlasehindeA PopoolaJ MassoudR MassoudTm SorourA JamalAa KerawalaAs MemonR Nafees AhmedL RaiB AyubN HassanRs MartinsP RameshR SayyedU ButtM KashifM KashifWh KhanA QureshiM UmarM Waris FarookaT WasimA AyubiI RashidSh WaqarGm FalconR RoblesR JocsonC TehP MajorM BobińskiJ KotarskiK Rasoul-PelińskaC AzevedoD MachadoF MendesX de SousaU FernandesC FerreiraG GuidiC LealA MarçalR MarquesD MartinsA MeloN TenreiroR Vaz PereiraB VieiraJi AlmeidaT Correia de SáMjma CostaV FernandesI FerrazCg GilC Lima da SilvaL LopesN MachadoJ MarialvaM Nunes CoelhoJ PedroC PereiraR ReisA RibeiroR SantosP SaraivaR SilvaF TavaresM TeixeiraAc AlmeidaMj AmaralR AndradeR Athayde NemésioD BredaC CamachoC CanhotoM ColinoS CorreiaM CostaJ de BarrosAl de Oliveira LópezM DuqueS GarridoP GuerreiroA GuimarãesA LázaroC LopesR MartinsO NogueiraA OliveiraJm OliveiraM RodriguesA RuivoE SantosM SilvaJ SimõesA Valente da CostaA AlmeidaS CavaleiroV DevezasCs FariaF JácomeM Magalhães MaiaJ NogueiroA PereiraA Pereira-NevesT Pina-VazH Santos-SousaH SilveiraS VazP VieiraA Gomes da CostaI Lobo AntunesJ PintoA TojalN CardosoP CardosoJc DominguesP HenriquesMi MansoG Martins dos SantosR MartinsH MoraisR PereiraT RevezR RibeiroVi RibeiroA SoaresS SousaJ TeixeiraE AmorimVh BaptistaB Cunha MfdiasA FazendaJp Melo NevesF PolicarpoIi Sampaio da Nóvoa Gomes MiguelD VeigaAk AndradeJp BandovasN BorgesA BranquinhoB ChumbinhoJ CorreiaH FidalgoI Figueiredo de BarrosS FradeJ GomesJ MacielS PinaA RodriguesN SilvaI Silveira NunesR SousaJ AscensãoP AzevedoB CosteiraC CunhaR GarridoH GomesI LourençoG MendinhosP MirandaA Nobre PintoM Peralta FerreiraJ RibeiroL Rio RodriguesM Sousa FernandesJ AzevedoD GalvãoAc SoaresA VieiraB VieiraB PatrícioPmdd SantosAc Vieira Paiva LopesR CunhaA FaustinoA FreitasJr Martins AbmendesR ParreiraJ RosaM TevesA Abreu da SilvaM ClaroD Costa SantosAc DeusJv GriloF BorgesJ Corte RealS HenriquesMj LimaP Matos CostaF Brito da SilvaA CaiadoF FonsecaM ÂngeloJm BaiaoD Martins JordãoT Vieira CaroçoJ MessiasA MillanI SalgadoP SantosC BaíaR CanotilhoAm CorreiaAp Ferreira PintoM PeyroteoJf VideiraP EscobarM Maldonado SantiagoR KassirF SauvatC BezedeA ChitulE CioficD CristianF GramaL PirteaC SecosanE BonciV GataS TituO GinghinaN IordacheRv IosifescuT GarmanovaE KazachenkoD MarkaryanS RodimovP TsarkovI TulinaY LitvinaA ProvozinaM AgapovE GalliamovV KakotkinV KubyshkinА КамаловM AlshahraniF AlsharifM EskanderR Al RaddadiS MajrashiA MashatN AkeelM AlharthiM AljiffryM BasendowahA FarsiM GhunaimA KhojaA MaghrabiN MalibaryM NassifA NawawiA SaleemA SamkariN TrabulsiS Al AwwadM AlghamdiT AlnumaniM NasserA Said BayazeedA AlhefdhiO AlmalikA AlomairN AlotaibiF AlresainiR AlsalamahS AlsobhiZ MahasinE OthmanS VelagapudiS GhedanR AlharthiS AwadM I ShararaS AbdelrahmanW AlthobaitiH Al HabesA AlamriS AlkarakM AlqannasM AlyamiM AlzamananD Cortés GuiralA ElawadO AlaamerL AlriyeesN AlselaimA AbdulkareemA AjlanK AkkourA Al-HabibK Al-KhayalA AlatarA AlburakanH AlhalalB AlhassanN AlhassanO AlobeedA AlsaifF AlsaifS AlshammariI AlshaygyM BarryA Bin NasserT Bin TraikiA BokhariS ElwatidyH HelmiA MadkhaliT NouhPd RabahA ZubaidiI PaunovicN SlijepcevicL AleksićA AnticG BarisicM CeranicD GalunŽ GrubačJ JelenkovicD KecmanovićS KmezićD KnezevicZ KrivokapicS LatinčićV MarkovicS MatićM MiladinovM PavlovI PejovicD RadenkovicB TadicJ VasljevićD VelickovicM ZivanovicM PerovicL SrbinovicS AndrijasevicT BozanovicR Cerovic PopovicM DokicT JanjicK JeremicS KadijaI Ladjevic LikicL MirkovicS PantovicI PilicM RadojevicA StefanovicS VidakovicZ VilendecicS AnticD DunđerovićD JelovacZ JezdicV KonstantinovicB KotlarC KuzmanovicM LazićM PetrovicF PopovicA PucarM RomicS SumrakV VujanacV BascarevicI BogdanovićD GrujičićR IlicM MilićevićF MilisavljevićA MiljkovićA PaunovicV ŠćepanovićA StanimirovicM TodorovicA JoticJ MilovanovicA TrivicU BumbasirevicZ DzamicB KajmakovićN PrijovićM ZivkovicM ButaA CvetkovicI DjurisicS GacicM GoranZ InicN JefticM JevricV JokicI MarkovicM MilanovićS NikolicL PejnovicN SavkovićI SpurnicD StevicD StojiljkovicN VucicM ZegaracA KaramarkovicM KenicB KovacevicI KrdzicV MilutinovićCw ChanB LieskeB GálisK ŠimkoN AlmglaM BernonA BoutallL CairncrossA HermanT HiltonE JonasC KloppersF MalherbeW MuglaD NelS RayamajhiT van WyngaardJ VogelAm Castaño-LeonJ Delgado FernandezC Eiriz FernandezM Espino Segura-IllaO Esteban SinovasD Garcia PerezP GomezL Jimenez-RoldanA LagaresL Moreno-GomezI ParedesA Pérez NúñezG Sánchez AnicetoM SantasP Fernández RodríguezM Paniagua García SeñoransR Sanchez-SantosV VigoritaE AcrichE Baena SanfeliuO BarriosT GoldaC SantanachM Serrano-NavidadM Sorribas GrifellRv VivesD EscolàA JiménezL Cayetano PaniaguaL Gómez FernándezE ArtiguesJc Bernal-SprekelsenJc Catalá BausetP ColleraL Diaz DeR GobboR Farre FontR Flores ClotetCj Gómez DíazN GuàrdiaCa GuarigliaA OsorioR Sanchez JimenezL SanchonC Soto MontesinosB Albi MartinJe García VillayzánL Alonso-LambertiM AssafN Baeza PintadoA CarabiasJ García-QuijadaMa Huertas FernandezJ Jimenez MiramónV JimenezJm JoverSa Landeo AgüeroR LeonMb Martín SalamancaV Pérez SimónS PonceJl RodriguezA SalazarA Valle RubioH AguadoI Aldecoa AnsorreguiR Bravo InfanteFb de LacyA Di SommaB Díaz-FeijooJ Enseñat NoraN FabregasA FerrésB Gil IbañezJj Gonzalez SanchezI GraciaJa Hoyos CastroAm LacyC LangdonD MomblánX MoralesL OleagaA OteroL PedrosaJ Poblete CarrizoLa Reyes FigueroaP Roldan RamosJ Rumia-ArboixAi Tercero-UribeTe TopczewskiJ ToralesA TorneR TornéV Turrado-RodriguezR ValeroS ValverdeR AnulaO Cano-ValderramaM del Campo MartínL Díez-ValladaresI DomínguezJ DziakovaM García AlonsoE García RomeroL Gómez LatorreJm MuguerzaMj PizarroP Saez CarlinC Sánchez del PuebloA Sánchez-PernauteG Sanz OrtegaR Sanz-LopezA TorresM Garcés-AlbirF LopezJ Martín-ArévaloD Moro-ValdezateV Pla-MartiJ Beltrán de HerediaB de Andrés AsenjoT Gómez SanzC JezienieckiH Nuñez del BarrioFj Ortiz de Solórzano AurusaA Romero de DiegoM Ruiz SorianoJ Trujillo DíazA Vazquez FernandezP Lora-CumplidoMv SosaE Gonzalez-GonzalezAm Minaya BravoN Alonso de la FuenteM Cazador LabatL CecchiniCa EspinosaM Jimenez ToscanoA López CampilloG ManceboP MartorellM MunarrizEj Grau-TalensB Martin-PerezJa Benavides BulejeM Carrasco PratsPv FernándezA Fernández-LópezD García EscuderoVj García PorcelV Garcia SoriaC Giménez FrancésFm González ValverdeE GurreaP López-MoralesA Marco GarridoJa Martínez AlonsoE MedinaJm Muñoz CamarenaPa Parra BañosE Peña RosM Ramirez FaracoM Ruiz-MarínC Sanchez RodriguezM Valero SorianoM Estaire GómezÁ Fernández CamuñasEp Garcia SantosE Jimenez HigueraC Martínez-PinedoV Muñoz-AtienzaD Padilla-ValverdeR Picón RodríguezFj Redondo CalvoS Sánchez-GarcíaD Sanchez-PelaezRc ColombariE del ValleM FernándezP Lozano LomincharL MartínC Rey ValcarcelMa SteinerM TudelaJ Zorrilla OrtúzarF Alcaide MatasJm García PérezP Troncoso PereiraI Mora-GuzmánM AbellánM Achalandabaso BoiraR JorbaR Memba IkugaC OlonaR Sales MallafréP Cavallé BusquetsMgp Gavalda PelliceJ Salinas PeñaEj Aragon AchigL BarbierP Caja VivancosA GainzaJj García GutierrezG Mallabiabarrena OrmaecheaH MarínP Martin PlayaI Melchor CorcósteguiM Prieto CalvoA Rodriguez FragaI Villalabeitia AtecaU de Andres OlabarriaM Durán BallesterosFj Fernández PablosFj Ibáñez-AguirreA Sanz LarrainzarB Ugarte-SierraÁ de la Hoz RodríguezM Di MartinoJ García SeptiemE Martin-PerezJl Muñoz de NovaP Calvo EspinoP Guillamot RuanoL Colao GarcíaD Díaz PérezE Esteban AgustíP Galindo JaraM Gutierrez SamaniegoMa Hernandez BartolomeJ Serrano GonzálezA Alonso PozaB DiéguezM García-CondeM Hernández-GarcíaM LosadaCm Chiesa-EstombaJá González GarcíaE LarruscainJa Sistiaga-SuárezE AlvarezN ChavarriasL FríasV García PinedaA Gegúndez SimónS GortázarM GraciaJ GuevaraA Hernández GutierrezA LoayzaDt María DoloresC MartíM MelendezE Moreno-PalaciosY PerezMi Prieto NietoP Ramos-MartínI Rubio-PerezJ SaavedraJi Sanchez-MendezJ Siegrist RidruejoA UrbietaI ZapardielM Cantalejo DiazMdc de Miguel ArdevinesV Duque-MallénI Gascon FerrerMt González-Nicolás TrébolC Gracia-RocheM Herrero LopezUm Jariod FerrerA LanzonA Martinez GermanM MatuteC RedondoN Sánchez FuentesM Sánchez-RubioMs Santero-RamirezS SaudíMv Simón SanzT Uson-BouthelierA Blazquez MartinM Diez AlonsoE García RicoE Garcia-Loarte GomezF Garcia-Moreno NisaA Gutierrez CalvoP HernandezI LasaF Mendoza-MorenoN Morales PalaciosE Ovejero MerinoC Vera MansillaF Acebes GarcíaM BailónAd Bueno CañonesE Choolani BhojwaniP Marcos-SantosT MiguelD Pacheco SánchezB Pérez-SaboridoJ Sanchez GonzalezFj Tejero-PintorF AlconchelA ConesaJ Gil MartínezAi Gutiérrez FernándezA Lopez AbadT Nicolás-LópezP Ramirez RomeroMj Roca CalvoK RodriguesJj Ruiz ManzaneraAi SorianoA CanoL Capitan-MoralesJ Cintas CatenaJ Gomez-RosadoF Oliva MompeanMa Pérez SánchezFd Río LafuenteC Torres ArcosJ Valdes-HernandezH CholewaS DomingoM FrassonV LagoT Marina MartinC Martínez ChicoteJ Sancho-MurielA Landaluce-OlavarriaD LecumberriA Abad GurumetaA Abad-MotosE Martínez-HurtadoJ Ripollés-MelchorA Ruiz EscobarA Cuadrado-GarcíaL Garcia-Sancho TellezJ Heras AznarP MatéI Ortega VázquezAl PicardoJa Rojo LópezF Sanchez Cabezudo NogueraD Serralta de ColsaJ Anchuelo LatorreC Cagigas FernandezR Caiña RuizM Gomez RuizF HernanzJ Jimeno FraileP Martínez-PérezC PochS Santarrufina MartinezV Valbuena JabaresC Moliner-SánchezL Pingarron-MartinJ Rey-BielI Ruiz MartinJl Blas LainaB CrosJ EscartinJ Garcia EgeaA NoguésI Talal El-AburC YánezEp Cagigal OrtegaI CerveraP Díaz PeñaGdcr ElenaD EnjutoP Fernández BernabéR Garcés GarcíaJ GonzalezI HernándezN Herrera-MerinoM Marqueta de SalasP Martinez PascualM Perez GonzalezA Ramos BonillaL Rodríguez GómezC BescósR Blanco-ColinoI BranaB CaimariA de Pablo García-CuencaF Duran-VallesE Espin-BasanyJ Giralt López de SagredoJ PamiasG PellinoN PratR Pujol PinaM Saez BarbaA ArulananthamGbk BandaraU JayarajahS RavindrakumarVs RodrigoS SrishankarAa Ali KararP ElbeEk LindqvistH TaflinA ÄlgåG HeiniusM NordbergE PieniowskiI GkekasN LöfgrenM RutegårdM SundM ArigoniM BernasconiD ChristoforidisM Di GiuseppeD La ReginaF MongelliM ChevallayO DwidarE GialamasM SauvainF KlenkeA KollàrC KurzeM AdaminaT BächlerAs CrugnaleM GiardiniL GuglielmettiG PerosF SolimeneA AghayevaI HamzaogluI SahinE AkaydinZ AliyevaE AytacB BacaO DülgeroğluV OzbenBb OzmenC UrasAe ArikanIa BilginB BozkırlıGo CeyhanH KaraT KarahasanoğluC UrasH CelikMm MeydanliH AkilliA AyhanE KuscuMa OnanU AkgorHa DincerT ErolM GultekinN OrhanN OzgulMc SalmanB SoyakA AlhamedS ErgünMf OzcelıkAn SanliSs UludağM VelidedeogluAk ZenginMa BozkurtY KaraA KocataşB CimenogluR DemirhanK Saracogluİf AzamatE BalikD BuğraB GirayCb KulleC TaskiranD VatanseverK GözalSa GülerH KökenOc TatarNz UtkanA YıldırımE YükselE AkinF AltintoprakZ BayhanG CakmakR ÇapoğluF ÇelebiH DemirE DikicierN FiratE GönüllüMb KamburoğluB KocerIf KüçükB MantogluE ÇolakGo KucukMs UyanikB GöksoyE BozkurtB CitgezM MihmanliM TanalG YetkinM AkalinC AricanEk AvciC AydinS Demirli AtıcıM EmirogluT KayaE KebabçıG KilincY KirmiziH ÖğücüS Salimoğluİ SertC TugmenK TuncerG UsluD YeşilyurtE KaramanA KolusarıA YildizO BensonH LuleJ AgilinkoA AhmeidatM BarabaszM BekheitLk CheungT CollocW CymesM ElhusseiniG GradinariuA HannahBs KameraG MignotS ShaikhP SharmaI Abu-NaylaA AgrawalA Al-MohammadS AliJ AshcroftA AziziO BakerA BalakrishnanM ByrneA ColquhounA CotterP CoughlinRj DaviesA DurraniM ElshaerS FordingtonP ForouhiF GeorgiadesH GrimesA HabeebV HudsonP HutchinsonE IruneA JahDz KhanA KoliasH KyriacouB LambS LiauL LukeR MahmoudR MannionL MastersonCg MitrofanM MohanA MorrisS MurphyR O’neillS PriceJ Pushpa-RajahW Raby-SmithJ RamziS RooneyT SantariusA SinghGd StewartXs TanA TownsonE TweedleC WalkerS WaseemS YordanovT JonesA KattakayamC LohR LuneviciusS PringleA SchacheR ShawA SheelC RossboroughD AngelouM ChoynowskiB McareeA MccannyD NeelyG TutoveanuS AhadMfi de la Cruz MonroyF MosleyV OktseloglouA AlanbukiM PatelA ShabanaE PereraD RaveendranK Ravi-ShankarJ ThiruchelvamL ArrowsmithW CampbellT GroveC KontovounisiosO WarrenP RollandA AggarwalS BrownC JelleyN NealR CliffordN EardleyE KrishnanN ManuE MartinS Roy MahapatraOl SerevinaC SmithD VimalachandranM BordenaveR HoustonG PutnamA RobsonH TustinK EmsliePl LabibA MarchbankD MillerG MintoJ NataleH NwineeP PanahiL RogersA AbubakarMm Akhter RahmanE ChanKyk KoH O’brienK SasapuH WoodunR InglisHj NgA de Gea RicoN GhazaliJ LambertG MarkoseS MathI SarantitisD ShresthaA SultanaM TaggarsiS TimbrellOp VazL VitoneA DayH DentM FahimS WaheedA HuntN LaskarA GuptaJ SteinkeS ThrumurthyE MassieK McgivernD RutherfordM WilsonJ HardieS KazzazS HandaM KaushalA KlerP PatelJ RedfernS TezasY AawsajS AmonkarC BarryL BlackwellD BlakeJ CarterH EmersonA FisherM KatoryP KorompelisW MccormickA MustafaL PearceN RatnaveluR ReehalL KretzmerL LalouB MankuI ParwaizJ StaffordM AbdelkarimA AsqalanT GalaS IbrahimA MawR MithanyR MorganG Sundaram VenkatesanK AngEj CaruanaMf ChowdhryA MohammadA NakasS RathinamM BoalO BrownS DwerryhouseS HiggsA VallanceE BoydV IrvineA KirkG BakolasA BoultonA ChandockT KhanM KumarP AgostonA BillèB ChallacombeS FraserK Harrison-PhippsJ KingG MehraL MillsM NajdyR NathL OkirorJ PillingV RizzoT RoutledgeA SayasnehL StromanA WaliM FehervariC FotopoulouN HabibS Hamrang-YousefiZ JawadL JiaoM PaiJ PloskiP RajagopalS SasoM SodergrenD SpaldingS LawsC HardieC McnaughtR AlamA BudacanJ CahillM KalkatS KarandikarL KenyonD NaumannA PatelJ AyorindeT ChaseT CumingA GhanbariL HumphreysS TayehA Aboelkassem IbrahimR BichooH CaoAkw ChaiJ ChoudhuryC EvansH FitzjohnH IkramM LangstrothM LoubaniA McmillanS NazirSsa QadriA RobinsonE RossT SehgalA WilkinsJ DixonJ DunningK FreystaetterM JhaS LesterA MadhavanSv ThulasiramanY ViswanathT Curl-RoperC DelimpaltaCcl LiaoV VelchuruE WestwoodE BelcherG Bond-SmithS ChidambaramF Di ChiaraK FasanmadeL FraserH FuM GanauS GoreJ GraystoneD JeyaretnaH KhatkarM LamiM MaherS MastoridisR MihaiR PiperS PrabhuObf RiskU SelbongK ShahR SmillieH Soleymani MajdS SravanamD StavrouliasGd TebalaM VatishC VerberneK WallworkS WinterMi BhattiH Boyd-CarsonE ElseyE GemmillP HerrodM JibreelE LenziT SaafanD SapreT SianN WatsonA AthanasiouG BourkeL BradshawA BrunelliJ BurkeP CoeF CostiganH ElkadiM HoJ JohnstoneA KanatasV KantolaA KaufmannA LaiosS LamE MacinnesS MunotC NahmM OtifyC PompiliI SmithG TheophilouG ToogoodR WadeD WardC WestS AnnamalaiC AshmoreA BoddyT HossainA KourdouliA GvaramadzeA JibrilL PrustyD ThekkinkattilA HarkyM ShackclothA AskariC ChanN CirocchiS KudchadkarK PatelJ SagarS ShawR TalwarM AbdallaR EdmondsonO IsmailD JonesK NewtonN StylianidesA AderombiU AndaleebO BajomoK BeatsonW GarrettM MehmoodV NgR Al-HabsiGs DivyaB KeelerB Al-SarirehR EganR HarriesA HenryM KitturZ LiK ParkinsF SolimanN SpencerD ThompsonC BurgessC GemmellC GriecoM HollymanL HuntJ MorrisonS OjhaN RyanF AbbadessaS BarnardC ChanN DaweJ HammondAli MahmoudI McphersonC MellorJ MoirS PandanaboyanaJ PowellB RaiA RogersC RoyA SachdevaC SalehS TingleT WilliamsJ ManickavasagamC McdonaldN McgrathN McsorleyK RagupathyL RamsayA SolthO KakisiK SeebahI ShaikhL SreedharanM YoussefJ ShahP AmeerallyN MclartyS MillsA ShenfineK SahnanJ AbuE Addae-BoatengD BrattL BrockN BurnsideS Cadwell-SneathK GajjarC GanC GrundyK HallamK HassellM HawariA JoshiH KhoutK KonstantinidiRxn LeeD NunnsR SchiemerT WaltonH WeaverL WhiskerK WilliamsonJ McveighR MyattMa WilliamsR KaurE LeungS SundarM MichelS PatilS RavindranJ SarveswaranL ScottM EdmondE KingM AlmondA BhanguO BreikLd CatoA DesaiS FordE GriffithsM IdleM KamalA KisielR KulkarniJkc MakT MartinP NankivellA ParenteS ParmarAm PathankiL PhelanP PraveenS SaeedN SharmaJ SinghF TirottaD VijayanA GeddesJ MccaulJ McmahonAh KhanF KhanA MansuriS MukherjeeM PatelM SarigulS SinghKl TanA WoodhamA AdiamahH BrewerA ChowdhuryJ EvansD HumesJ JackmanA KohC Lewis-LloydO OyendeJ ReillyD WorkuP CoolG CribbK ShepherdC BissetS MougN ElsonG FaulknerP SalehC UnderwoodG BrixtonL FindlayT KlatteA MajkowskaJ MansonR PotterA BhallaZ ChiaP DaliyaA GoyalE GrimleyA HamadA KumarFl MalcolmE TheophilidouJ BowdenN CampainI DanielsC EvansG FowlerJ JohnL MasseyF McdermottJ McgrathA MclennanM NgJ PascoeN RajaretnamS BulathsinhalaB DavidsonG FusaiC Hidalgo SalinasN MachairasT PissanouJm PollokDa RaptisF SoggiuH TzerbinisSe XydaA BeamishE DaviesR FoulkesD MagowanH NassaR OoiC PriceL SmithF SolariA TangG WilliamsY Al-TamimiA BaconN BeasleyD ChewM CrankN IlenkovanM MacdonaldB NariceO RominiyiA ThompsonI VarleyT DrakeE HarrisonG LinderJ MayesR McgregorR SkipworthV ZamvarE DaviesP HawkinT RaymondO RyskaR BaronD DunneS GahuniaC HalloranN HowesR MckinneyF McnicolJ RussP SzatmaryJr TanA ThomasP WhelanA AnzakA BanerjeeO FuwaF HughesJd JayasingheC KnowlesH KocherI Leal SilvaFs LedesmaA MinicozziL NavaratneR RahmanR RamamoorthyC SohrabiM ThahaB ThakurM VennV YipR BaumberJ ParryS EvansL JeysG MorrisM ParryJ StevensonN AhmadiG AresuZm Barrett-BrownAs CoonarH Durio YatesD GearonJ HoganM KingA PerytIs PradeepC SmithM AdisheshR AthertonK BaxterM BrocklehurstM ChaudhuryN KrishnamohanJ McaleerG OwensE ParkinP PatkarI PhangA AladeojebiM AliB BarmayehvarA GauntM GowdaE HallidayM KitchenF MansourM ThomasD ZakaiN Abbassi-GhadiH AssalaarachchiA CurrieM FlavinA FramptonM HagueC HammerJ HopperJ HorsnellS HumphriesA KamockaTk MadhuriS PrestonP SinghJ StebbingA TailorD WalkerF AljanadiM JonesP MhanduC O’donnellR TurkingtonZ Al-IshaqS BhasinAs BodlaA BuraheeA CrichtonR FossettN PigadasS PickfordE RahmanD SneeR VidyaN YassinF ColomboD FountainMt HasanK KarabatsouR LaurenteO PathmanabanA Al-MukhtarS BrownJ EdwardsA GiblinC KeltyM LeeG LyeT NewmanA SharkeyC SteeleN Sureshkumar ShahE WhitehallR AthwalA BakerL JonesC KonstantinouS RamcharanS SinghJ VatishR WilkinM EthunandanGk SekhonH ShieldsR SinghF WensleyS LawdayA LyonsT AbbottS AnwarK GhufoorC SohrabiE ChungR HaggerA HainsworthA KarimH OwenA RamwellK WilliamsC BakerA DaviesJ GossageM KellyW KnightJ HallG HarrisG JamesC KangDj LinAd RajgorT RoyleR ScurrahB SteelLj WatsonD ChoiR HutchisonA JainV LuomaH MarcusR MayA MenonB PramodanaL WebberIa AnekeP AsaadB BrownJ CollisS DuffA KhanF MouraB WadhamH WarburtonT ElmoslemanyM JenkinsonC MillwardR ZakariaS MccluneyC ParmarS ShahJ AllisonMs BabarB CollardS GoodrumK LauA PatelR ScottE ThomasH WhitmoreD BalasubramaniamB JayasankarS KapoorA RamachandranA ElhamsharySmb ImamK KapriniotisV KasivisvanathanJ LindsayS Rakhshani-MoghadamN BeechM ChandL GreenN KalavrezosH KiconcoR McewenC SchillingD SinhaJ PerecaJ SinghS ChopraD EgbeareR ThomasT CombellackSef JonesM KornaszewskaM MohammedA SharmaG TahhanV ValtzoglouJ WilliamsP EskanderK GashL GourbaultM HannaT MaccabeC NewtonJ OlivierS RozwadowskiE TehD WestH Al-OmishyM BaigH BatesG Di TarantoK DicksonN DunneC GillD HoweD JeevanA KhajuriaK Martin-Ucar AmcevoyP NaredlaV NgS RobertsonM SaitDr SarmaS ShanbhagT ShortlandS SimmondsJ SkillmanN TewariG WaltonMa AkhtarA BruntJ McintyreK MilneMm RashidA SgròKe StewartA TurnbullM Aguilar GonzalezS TalukderC BoyleD FernandoK GallagherA LairdD ThamM BathP PatkiC SohrabiC TanabalanT ArifC MageeT NambirajanS PowellR VinayagamI FlindallA HansonV MahendranS GreenM LimL MacdonaldV MiuL OnosK SheridanR YoungF AlamO GriffithsC HouldenR JonesVs KolliAk LalaS LeesonR PeevorZ SeymourL ChenE HendersonA LoehrerK BrownD FlemingA HaynesC HeronC HillH KayE LeedeK McelhinneyK OlsonEc OsterbergC RileyP SrikanthM ThornhillD BlazerG DilallaEs HwangW LeeM LidskyJ PlichtaL RosenbergerR ScheriK ShahK TurnageJ VisgaussS ZaniJ FarmaJ ClarkD KwonE EtchillHe Gabre-Kidan AjennyA KentM LaddC LongH MalapatiA MargalitS RapaportJ RoseK StevensL TsaiD VervoortP YesantharaoA DehalD KlaristenfeldK HuynhL BrownI GanlyJ MullinaxN GusaniJ HazeltonJ MainesJs OhA SsentongoP SsentongoM AzamA ChoudhryW MarxJ FlemingA FusonJ GigliottiA OvaittY YingMk AbelV AndayaK BigayMa BoeckL ChenH ChernC CorveraI El-SayedA GlencerP HaBcs HamiltonC HeatonK HiroseDm JablonsK KirkwoodLz KornblithJr KratzR LeePn MillerE NakakuraB Nunez-GarciaR O’donnellD OzgedizP ParkB RobinsonA SarinB SheuM VarmaK WaiR WustrackMj XuD BeswickJ GoddardJ ManorJ SongT FullmerC GaskillN GrossK KiongCl RolandSn ZafarM AbdallahA AbouassiM AlmasriG KulkarniH MarwanM MehdiS AounVs BanHh BatjerJ CarusoD AbbottA AcherT AikenJ BarrettE FoleyP SchwartzSn ZafarA HawkinsA MaigaJ LauferS Scasso
• Organismes : University of Birmingham [Birmingham] University of Birmingham [Birmingham] University of Glasgow Institute IMDEA Networks [Madrid] Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Journal of Clinical Oncology le 01/11/2020

---

Résumé : As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.

---

Source