Yassine HILMI

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2019
• Auteurs : A.K. MagnanGarschagen M.Jean-Pierre GattusoHay J.Caroline HilmiE HollandF. IslaG. KofinasInigo J. LosadaJ. PetzoldB. RatterT. SchuurT. TabeR. Van
• Organismes : LIttoral ENvironnement et Sociétés Laboratoire d'océanographie de Villefranche Centre Scientifique de Monaco Department of Physics [Heraklion]

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• Type de publi. : Article dans une revue
• Date de publi. : 21/01/2016
• Auteurs : Thomas Lacoue-LabarthePaulo A.L.D. NunesPatrizia ZiveriMine CinarFrédéric GazeauJason M. Hall-SpencerCaroline HilmiPaula MoschellaAlain SafaDidier SauzadeCarol Turley
• Organismes : LIttoral ENvironnement et Sociétés Environment Laboratories Institute of Marine Sciences / Institut de Ciències del Mar [Barcelona] La Banque Mondiale = The World Bank Institució Catalana de Recerca i Estudis Avançats = Catalan Institution for Research and Advanced Studies Loyola University [Chicago] Laboratoire d'océanographie de Villefranche Marine Biology and Ecology Research Centre Centre Scientifique de Monaco Environment Laboratories The Mediterranean Science Commission Skill Partners CAR/PB Centre d'Activités Régionales / Plan Bleu Plymouth Marine Laboratory
• Publié dans Regional Studies in Marine Science le 28/10/2020

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Résumé : Mediterranean Sea fisheries supply significant local and international markets, based largely on small pelagic fish, artisanal fisheries and aquaculture of finfish (mainly seabass and seabream) and shellfish (mussels and oysters). Fisheries and aquaculture contribute to the economy of countries bordering this sea and provide food and employment to coastal communities employing ca 600,000 people. Increasing temperatures and heat wave frequency are causing stress and mortality in marine organisms and ocean acidification is expected to worsen these effects, especially for bivalves and coralligenous systems. Recruitment and seed production present possible bottlenecks for shellfish aquaculture in the future since early life stages are vulnerable to acidification and warming. Although adult finfish seem able to withstand the projected increases in seawater CO2, degradation of seabed habitats and increases in harmful blooms of algae and jellyfish might adversely affect fish stocks. Ocean acidification should therefore be factored into fisheries and aquaculture management plans. Rising CO2 levels are expected to reduce coastal biodiversity, altering ecosystem functioning and possibly impacting tourism being the Mediterranean the world’s most visited region. We recommend that ocean acidification is monitored in key areas of the Mediterranean Sea, with regular assessments of the likely socio-economic impacts to build adaptive strategies for the Mediterranean countries concerned.

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Fichiers liés : Pub WG4 RSMS HAL.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2016
• Auteurs : Caroline HilmiTamatoa BambridgeAlain SafaBran QuinquisPaul D’arcy
• Organismes : Centre Scientifique de Monaco Environment Laboratories Centre de recherches insulaires et observatoire de l'environnement Université Nice Sophia Antipolis (1965 - 2019) EDHEC Business School Centre de recherches insulaires et observatoire de l'environnement ANU College of Asia & the Pacific

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 05/06/2015
• Auteurs : Albert Abraham MarouaniCaroline HilmiAlain SafaNicolas PascalMarie-Yasmine Dechraoui BotteinM. Warnau
• Organismes : Groupe de Recherche en Droit, Economie et Gestion COMUE Université Côte d'Azur (2015-2019) Centre Scientifique de Monaco Université Nice Sophia Antipolis (1965 - 2019) Centre de recherches insulaires et observatoire de l'environnement Laboratoire d'Excellence CORAIL Marine Environment Laboratories [Monaco]

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Résumé : La prévision des risques écotoxicologiques passe par une approche systémique et critique de la notion de développement durable. En envisageant, pour la Nouvelle Calédonie, un risque potentiel maximal d'augmentation des efflorescences algales nuisibles, nous mettons en évidence l'articulation des risques écologiques, biologiques, sanitaires et socioéconomiques (loisirs, tourisme, pêche, habitudes alimentaires, santé, culture et structures politiques). Nous évoquons en conclusion la question de la gouvernance d'un risque environnemental à partir de la notion de « bien public mondial » et de « rationalité collective ».

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Fichiers liés : Article NC final.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2008
• Auteurs : Caroline HilmiLionel LarribèreSandy GiulianoKarine BilleJean-Paul OrtonneRobert BallottiCorine Bertolotto
• Organismes : Biologie et pathologies des cellules mélanocytaires : de la pigmentation cutanée aux mélanomes Biologie et pathologies des cellules mélanocytaires : de la pigmentation cutanée aux mélanomes Biologie et pathologies des cellules mélanocytaires : de la pigmentation cutanée aux mélanomes Biologie et pathologies des cellules mélanocytaires : de la pigmentation cutanée aux mélanomes Biologie et pathologies des cellules mélanocytaires : de la pigmentation cutanée aux mélanomes Service de Dermatologie [Nice] Biologie et pathologies des cellules mélanocytaires : de la pigmentation cutanée aux mélanomes Biologie et pathologies des cellules mélanocytaires : de la pigmentation cutanée aux mélanomes
• Publié dans Journal of Investigative Dermatology le 24/10/2020

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Résumé : IGF1 plays a key role in the development and growth of multiple tumors and in the prevention of apoptosis. In melanoma cells, IGF1 has been shown to mediate resistance to anoikis-induced apoptosis. However, the effect of IGF1 on other proapoptotic stimuli has never been reported. Further, the molecular mechanisms by which IGF1 mediates its prosurvival properties in melanoma cells remain unknown. Here, we demonstrate that IGF1 impairs the onset of tumor necrosis factor-related apoptosis-inducing ligand and staurosporine-induced apoptosis in melanoma cells expressing either wild-type or oncogenic B-Raf. Further, we show that IGF1 inhibits mitochondrial damage that occurs during apoptosis, thereby indicating that IGF1 acts at the level of mitochondria to mediate its antiapoptotic stimuli. Accordingly, IGF1 increases the mRNA levels and protein expression of antiapoptotic members of the BCL2 family--BCL2 and BCL-X(L)--and that of the inhibitor of apoptosis protein, survivin. Further, their specific silencing by small interfering RNA prevents the protective effect of IGF1. These findings therefore delineate the molecular mechanisms by which IGF1 mediates its prosurvival properties and provide a basis for clinical strategies designed to neutralize IGF1 or its target genes.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/05/2003
• Auteurs : Christelle CorauxCaroline HilmiM RouleauAnne SpadaforaJocelyne HinnraskyJean-Paul OrtonneChristian DaniDaniel Aberdam
• Organismes : Biologie et physiopathologie de la peau Biologie et physiopathologie de la peau Biologie et physiopathologie de la peau Biologie et physiopathologie de la peau Dynamique cellulaire et moléculaire de la muqueuse respiratoire Biologie et physiopathologie de la peau Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer Biologie et physiopathologie de la peau
• Publié dans Current Biology le 31/10/2020

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Résumé : Embryonic stem (ES) cell lines can be expanded indefinitely in culture while maintaining their potential to differentiate into any cell type. During embryonic development, the skin forms as a result of reciprocal interactions between mesoderm and ectoderm. Here, we report the in vitro differentiation and enrichment of keratinocytes from murine ES cells seeded on extracellular matrix (ECM) in the presence of Bone Morphogenic Protein-4 (BMP-4) or ascorbate. The enriched preparation of keratinocytes was able to form an epidermal equivalent composed of a stratified epithelium when cultured at the air-liquid interface on a collagen-coated acellular substratum. Interestingly, an underlying cellular compartment that belongs to the fibroblast lineage was systematically formed between the reconstituted epidermis and the inert membrane. The resulting tissue displayed morphological patterns similar to normal embryonic skin, as evidenced by light and transmission electron microscopy. Immunohistochemical studies revealed expression patterns of cytokeratins, basement membrane (BM) proteins and late differentiation markers of epidermis, as well as fibroblast markers, similar to native skin. The results demonstrate the capacity of ES cells to reconstitute in vitro a fully differentiated skin. This ES-derived bioengineered skin provides a powerful tool for studying the molecular mechanisms controlling epidermal and dermal commitments.

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